The parasitic life cycle of helminths greatly relies on sophisticated manipulation of host environment and successful evasion of host defense. Helminths produce a repertoire of secretory molecules (including, extracellular vesicles and/or exosomes) to invade and generate habitable host-environment, and also to modulate the host immune responses in such a way that ensures their prolonged survival within host. An outline on helminths derived immune-modulatory molecules and their implications in host-parasite crosstalk have been presented. Queries with regard to the new direction of investigation to reveal specific molecular strategies, used by helminths to manipulate the host systems are also discussed.
Part of the book: Parasitic Helminths and Zoonoses