Different methods of measuring portal pressure.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"538",leadTitle:null,fullTitle:"Diagnostic Techniques and Surgical Management of Brain Tumors",title:"Diagnostic Techniques and Surgical Management of Brain Tumors",subtitle:null,reviewType:"peer-reviewed",abstract:"The focus of the book Diagnostic Techniques and Surgical Management of Brain Tumors is on describing the established and newly-arising techniques to diagnose central nervous system tumors, with a special focus on neuroimaging, followed by a discussion on the neurosurgical guidelines and techniques to manage and treat this disease. 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Krzysztof Zając, Hubert Huras, Joanna Streb and Olivia Dziadek",reviewType:"peer-reviewed",authors:[{id:"28893",title:"Dr.",name:"Klaudia",middleName:null,surname:"Stangel-Wojcikiewicz",fullName:"Klaudia Stangel-Wojcikiewicz",slug:"klaudia-stangel-wojcikiewicz"},{id:"99016",title:"Dr.",name:"Robert",middleName:null,surname:"Jach",fullName:"Robert Jach",slug:"robert-jach"},{id:"99053",title:"Dr.",name:"Grzegorz",middleName:null,surname:"Dyduch",fullName:"Grzegorz Dyduch",slug:"grzegorz-dyduch"},{id:"99056",title:"Dr.",name:"Malgorzata",middleName:null,surname:"Radon-Pokracka",fullName:"Malgorzata Radon-Pokracka",slug:"malgorzata-radon-pokracka"},{id:"99058",title:"Dr.",name:"Joanna",middleName:null,surname:"Dulinska-Litewka",fullName:"Joanna Dulinska-Litewka",slug:"joanna-dulinska-litewka"},{id:"99061",title:"Dr.",name:"Olivia",middleName:null,surname:"Dziadek",fullName:"Olivia 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Srivastava"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"76194",title:"Brief Review of Portal Hypertension Related Complications",doi:"10.5772/intechopen.96646",slug:"brief-review-of-portal-hypertension-related-complications",body:'Vesalius [1] was the person who drew an anatomical picture of the portal venous system in 1543 and described a case of bleeding hemorrhoids and suggested that this was due to a dilatation of the portal branches. Glisson [2] at a dissection in London, in 1650 established that blood was collected from the gastrointestinal tract by portal vein and finally to the systemic circulation.
Morgagni described a patient who had died from gastrointestinal hemorrhage: at the autopsy, dilatation of the splenic vein and of the short gastric veins were found.
The name cirrhosis was introduced in 1819, in Paris, by Renè Laennec, deriving from two words of the antique Greek: Skirros (hard, fibrotic) and Kirrhos (yellowish). He used the word “cirrhosis” in the textbook published by him [3].
Dusaussey [4], wrote an important thesis ‘Studies on esophageal varices in liver cirrhosis’, in 1872. He believed that the obstruction to portal flow was a consequence of liver cirrhosis.
Gilbert [5] introduced the term portal hypertension in 1902. A ‘pressure close to that in the portal vein’ without opening the abdomen, was obtained by puncturing one of the dilated abdominal wall veins (the caput medusae) by Davidson [6].
Thompson (1937) [7] directly measured portal pressure for the first time, with the open abdomen, the pressure in the portal vein and in the inferior vena cava. In 1953 Lebon et al. [8] diagnosed portal hypertension by percutaneous measurement of the intrasplenic pressure.
Patients with portal hypertension are identified when they present to hospitals or clinic after they have complications such as ascites, gastrointestinal bleeding, hepatic encephalopathy or hypersplenism. The pressure gradient between the portal vein and the inferior vena cava (the so-called portal perfusion pressure of the liver or portal pressure gradient) increases to greater than the normal range of values (1–5 mm Hg) when there is pathologic increase in portal pressure, which is called portal hypertension [9].
While evaluating them the need for the evaluating the underlying cirrhosis, the degree of portal hypertension, the site of obstruction and the presence of collateral circulation makes the diagnosis of portal hypertension complete [10]. As the disease progresses, the amount of fibrosis increases and in parallel the portal pressure rises corresponding to worsening in the prognosis. Direct or indirect measurement of portal pressure can be done with various methods.
Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard technique used to quantify the degree portal hypertension in liver disease. Diagnosis, classification, and monitoring of portal hypertension, risk stratification, identification of candidates for liver resection, and monitoring efficacy of β-adrenergic blockers are the main clinical applications of HVPG measurements.
HVPG is calculated as the difference between the wedged hepatic venous pressure (WHVP) and the free hepatic venous pressure (FHVP) [11]. The WHVP is measured by occluding a main hepatic vein which causes the static column of blood to transmit the pressure that is present in the preceding vascular territory i. e. the hepatic sinusoids. This measurement, in the absence of presinusoidal obstruction, reflects portal pressure [12]. The FHVP is a measure of the pressure of unoccluded hepatic vein. HVPG calculated with right atrial pressure shows a worse correlation with clinical outcomes, therefore FHVP should be used [13]. There are several methods to measure portal pressure as enumerated in Table 1.
SN | Methods | Procedures |
---|---|---|
1. | Indirect estimation of Portal hypertension | Ascitic fluid analysisSerum Ascitic Albumin Gradient(SAAG) ≥ 1.1 |
2. | Hepatic Vein Pressure Gradient (HVPG) | Open-ended catheter placed in one of the hepatic veins via a supraclavicular or internal jugular approach.Double-lumen balloon catheter placed in the hepatic vein via a femoral approach |
3. | Direct measurement of the portal pressure gradient | The portal vein can be catheterized directly, either by a trans hepatic approach or by a catheter placed via the umbilical vein. The added advantage is that collaterals can be embolized while this procedure. Angiography can be performed at the same time to minimize the number of procedures performed.Portal pressure measurements should be obtained prior to the injection of contrast, which in itself can alter pressures. |
4. | Intrahepatic portal vein pressure | Percutaneous catheterization of an intrahepatic branch of the portal vein with a thin Chiba needle; a catheter is passed via the intrahepatic branch into the main portal vein. |
5. | Intrasplenic pressure | Placement of a needle percutaneously in the substance of the spleen. |
6. | Umbilical vein catheter | Requires dissection to expose the umbilical vein; may require dilation of the umbilical vein to facilitate advancement of the catheter. |
Different methods of measuring portal pressure.
The changes in HVPG are due to the alterations in the intrahepatic resistance, collateral resistance, portal blood inflow or their combination [14]. Dynamic factors such as hepatic vascular tone and mechanical factors such as fibrosis, thrombosis and formation of regenerative nodules cause the alterations in HVPG.
The complications of portal hypertension increase as HVPG increases. Clinical manifestations and complications occur at a threshold of HVPG of 10 mm Hg, which is called clinically significant portal hypertension (CSPH). Different thresholds of HVPG correlate with different prognostic significance (Table 2).
HVPG | Clinical characteristics |
---|---|
< 5 mm Hg | Normal |
5–10 mm Hg | Mild portal hypertension |
>6 mm Hg | Progression of chronic viral hepatitis [15] |
High risk of recurrence after liver transplantation [16] | |
>10 mm Hg | Clinically significant Portal hypertension (CSPH) |
>10 mm Hg | Esophageal variceal development [17, 18] |
Decompensation with ascites [19] | |
Hepatocellular carcinoma (HCC) [20] | |
Decompensation after Hepatic resection [21] | |
>12 mm Hg | Variceal bleeding [22, 23] |
>16 mm Hg | High mortality [24] |
>20 mm Hg | Failure to control bleeding in acute variceal bleed [25] Low 1-year survival |
>22 mm Hg | High mortality in severe alcoholic hepatitis [26] |
>30 mm Hg | Spontaneous bacterial peritonitis (SBP) [27] |
Different thresholds of hepatic venous pressure gradient (HVPG) correlated with prognostic significance.
Hemodynamic measurement | Presinusoidal | Sinusoidal | Post-sinusoidal |
---|---|---|---|
FHVP (a) | Normal | Sinusoidal | Increased |
WHVP (b) | Normal or mild increased | Increased | Increased |
HVPG (b-a) | Normal or mild increased | Increased | Normal |
Hemodynamic measurements in portal hypertension.
Under sedation a balloon-tipped catheter is introduced through the central line inserted into the right internal jugular vein, usually under ultrasound guidance [28]. The catheter is advanced through the right atrium into the inferior venacava (IVC) under fluoroscopic guidance and then pushed into the right hepatic vein. Alternatively, the femoral approach can be used.
FHVP is obtained after the catheter is maintained in the hepatic vein 2 to 4 cm from its takeoff from the IVC. Typically, the difference in pressure between the IVC (measured at the hepatic vein ostium) and hepatic vein is ≤1 mmHg. If the difference is >1 mmHg it means the catheter is placed too deep into the hepatic vein. After this, WHVP is measured after the hepatic vein is occluded by inflating the balloon at the tip of the catheter. A small amount of contrast dye (5 mL) or carbon dioxide (if allergic to the contrast) is injected to confirm that the hepatic vein is occluded so that no reflux of the dye above the balloon or should washout via communications with other hepatic veins. Around 3 each measurements of wedged and free hepatic venous pressure are made each time with the stability of the value for at least 45–60 seconds [29]. Finally, the HVPG is calculated by subtracting the FHVP from the WHVP.
The findings of hemodynamic measurements in patients with intrahepatic portal hypertension are enumerated [28] in Table 3.
At the same time along with HVPG measurement include transjugular liver biopsy, measurement of hepatic blood flow and indocyanine green clearance, and wedged hepatic retrograde portography using carbon dioxide can be done. Complications during the procedure can be arrhythmia or injury to the local site.
Though these noninvasive tests cannot replace HVPG measurement for confirming the diagnosis of portal hypertension, ultrasonogram and transient elastography may be helpful.
Portal hypertension findings in transabdominal ultrasound are [28]:
Ascites
Splenomegaly (> 13 cm or Splenic index >20 cm2)
Coarse echotexture of liver with irregular margin and dull edge
Portal flow mean velocity < 12 cm/second
Reversal of flow in the portal vein and left gastric vein
Portosystemic collaterals (patent-paraumbilical vein, splenorenal collaterals, dilated left and short gastric veins)
Portal vein diameter > 13 mm
Decreased or no respiratory variation in splenic and superior mesenteric vein diameter
Portal/splenic/superior mesenteric vein thrombosis
Transient elastography using ultrasound is a noninvasive method for detecting hepatic fibrosis. Studies are also looking at it as an option for noninvasively diagnosing portal hypertension.
A value <13.6 kPa can be used to rule out portal hypertension, whereas a value ≥21.1 kPa is likely to have portal hypertension [28].
With the concept of physics, it is important to note that portal hypertension is related to both flow and resistance.
Pressure (P) equals flow (Q) times resistance (R), demonstrated by the formula.
Resistance is a function of the length and radius as shown by the formula R = 8n L/IIr4, where n is the coefficient of viscosity, L is the length of the vessel, and r is the radius. The pathophysiology of portal hypertension is explained in Figure 1.
Pathophysiology of portal hypertension.
Various etiologies of portal hypertension can be enumerated as:
Splenic vein thrombosis
Portal vein thrombosis
Congenital portal vein stenosis
Cavernomatosis of the portal vein
Arteriovenous fistula
Tropical splenomegaly
Presinusoidal: Schistosomiasis
Sarcoidosis
Primary Biliary Cirrhosis (Early)
Chronic active hepatitis
Congenital hepatic fibrosis
Hepatic artery portal vein fistula
Porto-sclerosis
Drugs
Arsenic, copper sulfate and Vinyl chloride poisoning.
Amyloidosis
Tuberculosis
Wilsons disease
Hemochromatosis
Mastocytosis
Sinusoidal: Acute alcoholic Hepatitis
Liver cirrhosis independent of etiology
Amyloidosis
Partial nodular transformation
Nodular regenerative hyperplasia
Hypervitaminosis A
Cytotoxic drugs
Acute fatty liver of pregnancy
Peliosis hepatitis
Polycystic liver disease
Idiopathic portal hypertension
Metastatic malignant disease
Post-sinusoidal: Veno-occlusive disease
Alcoholic central hyaline sclerosis
Budd-Chiari syndrome
Congenital malformations and thrombosis of the inferior vena cava
Constrictive pericarditis
Congenital heart diseases
Cardiomyopathy
Tricuspid valve diseases
Arteriovenous fistulas (splenic, aorto-mesenteric, aorto-portal, and hepatic artery-portal vein)
Formation of collateral circulation connects the portal blood vessels to systemic circulation, bypassing the liver and leading to portal hypertension [30]. Sometimes, when a pathological process causes occlusion of the splenic vein and the resultant elevated splenic bed venous pressure causes formation of gastric varices which can lead to hematemesis it is called sinistral portal hypertension. Sinistral portal hypertension is a rare, less than 1%, but life-threatening cause of upper gastric bleeding. In fact, the name sinistral portal hypertension is a misnomer since portal pressure is usually within the normal range in these cases. Other names for sinistral portal hypertension are left sided portal hypertension, segmental, regional, localized, compartmental, lineal, or spleno-portal hypertension [31, 32, 33]. It accounts for less than 5% of all patients with portal hypertension [33].
Chronic pancreatitis, pancreatic cancer, pancreatic cysts and neuroendocrine tumor are common causes of sinistral portal hypertension. Most involved vessel in pancreatitis-related splanchnic vein thrombosis is splenic vein followed by portal vein and mesenteric vein. It is mainly related to pancreatic inflammation and compression by pancreatic pseudocyst [34]. Around 8% of patients of chronic pancreatitis experience splenic vein thrombosis, the majority do not experience any form of symptomatic GI bleeding [35]. They present with hypersplenism, abdominal pain and gastrointestinal bleeding. They should undergo gastroscopy evaluation in search of varices. Suspicion of this portal hypertension should be done when patient has gastric varices only in fundus with or without any aberrant liver functions or features of liver cirrhosis with the presence of splenomegaly.
Iatrogenic splenic vein injury, ectopic spleen, colonic tumor infiltration, peri-renal abscess, post liver transplantation, Hodgkin’s disease, retro-peritoneal fibrosis, pancreatic transplantation, and spontaneous thrombus formation are among the less common causes of splenic vein thrombosis that can lead to left sided hypertension [31, 32].
Patients with portal hypertension are usually asymptomatic until they develop complications. Complications of portal hypertension include:
Variceal hemorrhage
Portal hypertensive gastropathy (PHG)
Ascites
Spontaneous bacterial peritonitis
Hepatorenal syndrome (HRS)
Hepatic hydrothorax
Hepatopulmonary syndrome (HPS)
Porto-pulmonary hypertension (POPH)
Portal hypertensive colopathy
Cirrhotic cardiomyopathy
Portal Biliopathy
Bleeding occurs in 30%–40% of patients with cirrhosis and varices [36]. The incidence of first variceal bleeding is about 12–15% per year in patients with cirrhosis and esophageal varices and mortality ranges from 17% - 57% in patients at first episode of variceal bleeding [37]. Carbonell et al. has also estimated mortality during the first episode of bleeding to be 15–20% but with Child Pugh C, it is around 30% [38].
The preventive measures advocated are beta blockers and endoscopic variceal ligation (EVL). Beta blockers provide protection against rebleeding after index hemorrhage while local obliteration of varices is done by EVL.
Nonselective beta blockers have been used daily in patients with cirrhosis and portal hypertension with varices either for primary or secondary prophylaxis. Recommended agents for primary prophylaxis of variceal hemorrhage are propranolol and nadolol [39, 40].
Secondary prophylaxis with nonspecific beta blocker (NSBB) has been shown to be effective in decreasing both the risk of recurrent bleeding and mortality [41, 42]. Without secondary prophylaxis, rebleeding occurs in approximately 60% to 70% of patients, usually within one to two years of the index hemorrhagic event [43]. Most used NSBB for secondary prophylaxis is propranolol but carvedilol can also be used. The decrease in HR at 6 weeks was significantly higher in carvedilol than propranolol group (p = 0.036). The rebleeding at least once within 6 months was also higher in propranolol group than carvedilol group (32 vs. 22.7%) [44].
It is the characteristic appearance which is a mosaic-like pattern or a diffuse, erythematous and reticular cobblestone pattern of gastric mucosa consisting of small polygonal areas, with or without superimposed red punctate lesions, >2 mm in diameter and a depressed white border [45, 46, 47]. PHG is classified as mild or severe.
Mild PHG has features like fine pink speckling (scarlatina-type rash), and mosaic pattern (snakeskin appearance) and Severe one has discrete red spots or diffuse hemorrhagic lesion [48].
The prevalence of PHG in Nepalese population with Chronic Liver Diseases (CLD) was 67 percent [49] though it varies significantly from 16 to 100 percentage [50]. Acute bleeding in PHG is estimated to occur in 2 to 12 percent [51].
Patients with cirrhosis with portal hypertension may present with ascites leading to distension of abdomen and dyspnea. They will have flank fullness with dullness on examination. The grading of ascites as graded by International Club for Ascites are [52]:
Grade 1 – Mild ascites detectable only by ultrasound examination
Grade 2 – Moderate ascites manifested by moderate symmetrical distension of the abdomen
Grade 3 – Large or gross ascites with marked abdominal distension
Ascites may range from mild to refractory. Mild to moderate ascites should be managed by modest salt restriction and combination of loop diuretics and potassium sparing diuretics.
Ultrasonographic detection of mild ascites is either pelvic or perihepatic or peri splenic ascites, while moderate ascites is presence of pelvic and perihepatic and perisplenic ascites, and marked ascites is diffuse ascites in the peritoneal cavity [52].
Diuretics should be added in a stepwise fashion along with sodium restriction. Gross ascites should be treated with therapeutic paracentesis followed by colloid volume expansion, and diuretic therapy. Sometimes refractory ascites is managed by repeated large volume paracentesis or insertion of a transjugular intrahepatic portosystemic stent shunt (TIPS) [53].
Spontaneous bacterial peritonitis occurs with a prevalence of 10–25% in cirrhotic patients with ascites [54]. It can be community acquired, health care associated or nosocomial.
Major pathogenic organisms are
Suspicion of nosocomial SBP should be done in a patient with SBP with a history of ICU stay during the previous 3 months or on prophylactic antibiotics for infection or had antibiotic treatment during previous 3 months or had a recent intervention in the hospital setting. Resistance to 3rd generation cephalosporins and quinolones has been documented in 40–50% of such cases [55].
Recently, Elsadek et al. found that Patients with SBP (n = 60) have significantly higher serum PEC index than those with sterile ascites (n = 118) (41.0/31.2–93.0 vs. 9.9/5.9–15.0, P < 0.001) and it distinguished culture positive cases significantly (P < 0.001) [56].
Diagnostic paracentesis should be performed in all patients who present with [57] (1) compatible signs or symptoms (abdominal pain and/or tenderness on palpation, fever, and chills); (2) impairment of the hepatic or renal function; (3) unexplained hepatic encephalopathy; (4) gastrointestinal bleeding.
SBP is diagnosed by polymorphonuclear cells ≥250 cells/mm3 in ascitic fluid in the absence of an intra-abdominal and surgically treatable source of infection. Other potential diagnostic methods are leukocyte esterase reagent strips (LERS), measurement of leukocyte-derived proteins such as granulocyte elastase and lactoferrin, detection of bacterial DNA using polymerase chain reaction (PCR) and detecting bacterial DNA in SBP ascites using in situ hybridization [57].
HRS occurs in the setting of advanced cirrhosis and portal hypertension [58] with prevalence of 13–45 percentage [59]. It is characterized by peripheral arterial vasodilatation and intrarenal vasoconstriction with decrease in renal blood flow and renal dysfunction. The most recent proposed diagnostic criteria for HRS-AKI are as-.
Diagnostic Criteria for HRS-AKI [60].
Cirrhosis with ascites; acute liver failure; acute-on-chronic liver failure
Increase in serum creatinine ≥0.3 mg/dl within 48 h or ≥ 50% from baseline value according to International Club of Ascites (ICA) consensus document and/or urinary output ≤0.5 ml/kg B.W. ≥ 6 h*
No full or partial response, according to the ICA consensus, after at least 2 days of diuretic withdrawal and volume expansion with albumin. The recommended dose of albumin is 1 gm/kg of body weight per day to a maximum of 100 gm/day
Absence of shock
No current or recent treatment with nephrotoxic drugs
Absence of parenchymal disease as indicated by proteinuria >500 mg/day, micro-hematuria (>50 red blood cells per high power field), urinary injury biomarkers (if available) and/or abnormal renal ultrasonography**.
Suggestion of renal vasoconstriction with FENa of <0.2% (with levels <0.1% being highly predictive)
*The evaluation of this parameter requires a urinary catheter.
**This criterion would not be included in cases of known pre-existing structural chronic kidney disease (e. g. diabetic or hypertensive nephropathy). AKI, acute kidney injury; FENa, fractional excretion of sodium; HRS, hepatorenal syndrome.
Nowadays, HRS has been classified as HRS-AKI and HRS-NAKI. The diagnosis.
of HRS-NAKI has been proposed to be made in the context of CKD, or AKD that does not meet the criteria for AKI and lasts for <90 days.
HRS-AKD is defined as a percent increase in sCr <50% or as an eGFR <60 min/ml per 1.73 m2 for <3 months with the fulfillment of the ICA criteria for HRS.
HRS-CKD defined as an eGFR <60 ml/min per 1.73 m2 for ≥3 months with the fulfillment of the ICA criteria.
Treatment can be done with terlipressin with albumin as medical treatment or with liver transplantation.
Hepatic hydrothorax (HH) is defined as the excessive (> 500 mL) accumulation of transudate fluid in the pleural cavity in patients with decompensated liver cirrhosis (LC) with exclusion of cardiopulmonary and pleural diseases [61]. It is present in 5–10% of cirrhotic patients. Right sided HH is common accounting for almost 85% of cases followed by left sided (13%). The mechanism of HH is due to negative intrathoracic pressure and liver acting as piston which results the ascitic fluid to move from the peritoneal cavity into the pleural space through small defects located mainly on the right side of the diaphragmatic tendon [61, 62]. Huang et al. [63] classified diaphragmatic defects into four types: (1) Type 1 - no obvious defects; (2) Type 2 – blebs lying on the diaphragm; (3) Type 3 – broken defects (fenestrations) in the diaphragm; (4) Type 4 – multiple gaps in the diaphragm.
The diagnostic criteria [61] for HH are listed in Table 4.
Criteria | Values |
---|---|
Count of white blood cells in pleural fluid Pleural effusion total protein level Pleural effusion total protein/serum total protein ratio Pleural effusion Lactate dehydrogenase (LDH)/serum LDH ratio Pleural effusion albumin/serum albumin ratio Pleural effusion bilirubin /serum bilirubin ratio pH Pleural effusion glucose level is equal to serum glucose level | < 250/mm3 < 25 g/L < 0.5 > 0.6 > 1.1 < 0.6 > 7.4 |
The diagnostic criteria for hepatic hydrothorax.
The options for treatment for refractory HH are low sodium diet with therapeutic thoracocentesis, pleurodesis, mesh repair of diaphragmatic defects, transjugular intrahepatic portosystemic shunt (TIPS), pleuro-venous or peritoneo-venous shunting though liver transplantation is the definite therapy.
HPS is defined as a disorder in pulmonary oxygenation, caused by intrapulmonary.
vasodilatation and, less commonly, by pleural and pulmonary arteriovenous communications occurring in the clinical setting of portal hypertension. HPS has been reported in 10% of patients with chronic viral hepatitis in 15–23% of those with cirrhosis and in 28% of those with Budd-Chiari syndrome [64].
The diagnostic criteria for HPS are [64]:
Hypoxia with partial pressure of oxygen <80 mmHg or alveolar–arterial oxygen gradient ≥15 mmHg in ambient air (≥20 mmHg in patients older than 65 years).
Pulmonary vascular defect with positive findings on contrast-enhanced echocardiography (i.e., microbubble opacification of the left heart chambers three to six cycles after right atrial passage) or abnormal uptake in the brain (>6%) with radioactive lung-perfusion scanning.
Spontaneous resolution of HPS is less likely and the definite treatment is liver transplantation however long-term oxygen therapy remains the most frequently recommended therapy for symptoms in patients with severe hypoxaemia. No established medical therapy is found however some improvement in Pao2 with garlic has been seen [65].
Vasoconstriction, vascular remodeling, and proliferative and thrombotic events within the pulmonary circulation lead to POPH. The presence of portal hypertension, hemodynamic measurements of mean pulmonary artery pressure > 25 mmHg at rest, mean pulmonary capillary wedge pressure < 15 mmHg, and pulmonary vascular resistance >240 dynes/cm−5 confirm POPH [66].
POPH is commonly diagnosed during fifth decade of life, 4–7 years after the presence of portal hypertension has been established [67]. Symptoms include dyspnea, fatigue, light headedness, and orthopnea in patients with liver cirrhosis or portal hypertension. Diuretics can be used for symptomatic control with close monitoring. Calcium channel blockers can worsen portal hypertension by causing mesenteric vasodilatation.
Severe portal hypertension can cause lower gastrointestinal bleeding and cause anemia. Portal hypertensive colopathy has been defined endoscopically in patients with vascular ectasia, redness, and blue vein. Vascular ectasia is classified into two types: type 1, solitary vascular ectasia; and type 2, diffuse vascular ectasia. Overall portal hypertensive colopathy is found in 2/3rd of the cirrhotic patients including solitary vascular ectasia in 36%, diffuse vascular ectasia in 42%, red ness in 21% and blue vein in 12 percent [68]. Worsening of Child Pugh class and decrease in platelet count increases prevalence of portal hypertensive colopathy in patients with liver cirrhosis warranting colonoscopy to prevent lower gastrointestinal bleeding.
The diagnostic criteria of cirrhotic cardiomyopathy [69] are enumerated in Table 5. Decreased cardiac responsiveness (chronotropic and inotropic incompetence) through the defect in cardiac β-adrenergic receptor signaling is the main mechanism for systolic dysfunction in cirrhotic cardiomyopathy. The presence of cardiodepressant substances such as nitric oxide (NO) and carbon monoxide (CO) and endogenous cannabinoids also play role [70, 71]. Potential mechanisms for diastolic dysfunction are alteration in collagen configuration, sodium retention and activation of renin angiotensin aldosterone System (RAAS) [72].
Systolic dysfunction | Resting ejection fraction <55% |
Blunted increase in cardiac output with exercise or pharmacological stimuli | |
Diastolic dysfunction | Early diastolic atrial filling (E/A ratio) < 1.0 (age corrected) |
Deceleration time (DT) > 200 ms | |
Prolonged isovolumetric relaxation time > 80 ms | |
Supportive criteria | Electrophysiological abnormalities (prolongation of QT) |
Abnormal chronotropic response | |
Electromechanical uncoupling | |
Enlarged left atrium | |
Increased myocardial mass | |
Increased brain natriuretic peptide or pro-peptide | |
Increased troponin I |
Diagnostic criteria for cirrhotic cardiomyopathy.
Salt and fluid restriction, diuretics and afterload reduction are the aspects of treatment in cirrhotic cardiomyopathy. Compared with non-cirrhotics the benefit of β-blockers in cirrhotic heart failure is not clear. The use of non-selective β-blocker has been shown to reduce prolonged QT interval toward normal values in patients with cirrhosis along with some beneficial effect in improving electromechanical uncoupling [73]. Possible cure for cirrhotic cardiomyopathy is liver transplantation.
Presence of biliary abnormalities in patients with non-cirrhotic/non-neoplastic extrahepatic portal vein obstruction (EHPVO) and portal cavernoma (PC) is called portal biliopathy. Compression of bile ducts by PC and/or to ischemic damage secondary to an altered biliary vascularization in EHPVO and PC leads to contribution of this complication.
Normally, epicholedochal venous plexus of Saint and the paracholedochal plexus of Petren, whose normal diameter does not exceed 1 mm, are responsible for the venous drainage of the biliary tree. Dilation of plexus of Saint causes fine irregularities in biliary walls while dilation of plexus of Petren causes extrinsic compression in chronic portal vein obstruction. Patients present with jaundice, cholangitis, cholecystitis, abdominal pain, and cholelithiasis. Around 5%–38% of patients develop biliary symptoms [74]. Dhiman et al. [75] identified four stages in PB progression (Table 6).
Stage | Portal cavernoma | Biliopathy | Liver function tests | Symptoms | Complications |
---|---|---|---|---|---|
Preclinic | Yes | No | Normal | No | No |
Asymptomatic | Yes | Early changes | Normal or abnormal | No | No |
Symptomatic | Yes | Advanced changes | Abnormal | yes | No |
Complicated | Yes | Advanced changes | Abnormal | Yes | Yes |
Characteristics of four stages in portal biliopathy natural history.
On the aspect of treatment, surgical porto-systemic shunt or transjugular intrahepatic porto-systemic shunt can be performed, and treatment on the biliary stenosis includes endoscopic (Endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy, balloon dilation, stone extraction, stent placement) and surgical (bilioenteric anastomosis, cholecystectomy) approaches are used for decompression of portal cavernoma.
Besides different surgeries with portosystemic shunting, there are newer drugs developed for reduction of portal pressure. Few drugs which have been seen to be beneficial are:
Obeticholic acid (OCA), a semisynthetic FXR agonist tested in preclinical models of cirrhosis has shown beneficial effects as transcriptional modulator on PH by reducing the intrahepatic vascular resistance (IHVR) [76].
Statins have antioxidative, antiproliferative and anti-inflammatory effects, and can improve endothelial dysfunction [77].
They have shown strong hepatosinusoidal protective effects in preclinical models of chronic liver diseases, ultimately leading to reduction in portal pressure [78, 79]. Simvastatin has shown beneficial effects when administered alone or combined with beta blockers [80, 81].
Emricasan has been seen to improve portal pressure and IHVR compared with vehicle-treated rats, in addition to improved liver function and microcirculation, and finally with improved liver sinusoidal endothelial cell (LSEC) and hepatic stellate cells (HSC) phenotype and reduced inflammation [82].
Rivaroxaban, direct inhibitor of factor Xa has been shown to reduce liver microthrombosis, HSC activation and portal pressure in experimental models of cirrhosis [83].
Liraglutide has shown antifibrotic effects in NASH patients, thus with high probabilities of success as a treatment for portal hypertension and chronic liver disease [84]. Metformin has shown to improve liver hemodynamic and fibrosis by a reduction in inflammation and oxidative stress [85].
Anti-inflammatory drugs such as rapamycin have reduced portal pressure in rats with Portal hypertension due to its intrahepatic and extrahepatic effects [86, 87].
Taurine has pleiotropic effects. A small cohort of patients with clinically significant PH (HVPG >12 mmHg) has reported reduction in portal pressure [88]. Thus, consumption of low carbonated ‘energy drinks’ rich in taurine may have a positive impact in portal hypertension.
Portal Hypertension is responsible for many complications in liver cirrhosis. Reduction of portal pressure decreases the rate of complications in advanced liver diseases. This can improve the quality of life and increase the survival of such patients.
None.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Polymorphism at the DNA level includes a wide range of variations from single base pair change, many base pairs, and repeated sequences. Genomic variability can be present in many forms, including single nucleotide polymorphisms (SNPs), variable number of tandem repeats (VNTRs, e.g., mini- and microsatellites), transposable elements (e.g., Alu repeats), structural alterations, and copy number variations. Different forms of DNA polymorphisms can be tracked using a variety of techniques; some of these techniques include restriction fragment length polymorphisms (RFLPs) with Southern blots, polymerase chain reactions (PCRs), hybridization techniques using DNA microarray chips, and genome sequencing. During the last years, the recent advance of molecular technologies revealed new discoveries of DNA polymorphisms. DNA polymorphisms are endless, and more discoveries continue at a rapid rate. Mapping the human genome requires a set of genetic markers. DNA polymorphism serves as a genetic marker for its own location in the chromosome; thus, they are convenient for analysis and are often used as in molecular genetic studies.",book:{id:"6719",slug:"genetic-diversity-and-disease-susceptibility",title:"Genetic Diversity and Disease Susceptibility",fullTitle:"Genetic Diversity and Disease Susceptibility"},signatures:"Salwa Teama",authors:[{id:"249329",title:"Dr.",name:"Salwa",middleName:null,surname:"Teama",slug:"salwa-teama",fullName:"Salwa Teama"}]},{id:"58467",title:"Generation of Antibody Diversity",slug:"generation-of-antibody-diversity",totalDownloads:3111,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Because of the huge diversity, the immunoglobulin repertoire cannot be encoded by static genes, which would explode the genomic capacity comprising about 20,000–25,000 human genes. The immunoglobulin repertoire is provided by the process of somatic germ line recombination, which is the only controlled alteration of the genomic DNA after meiosis. It takes place in mammalian B lymphocyte (B cells) precursors in the bone marrow. The genome germ line sequence of undeveloped B cells is organized in gene segments and compromise V (variable), D (diversity), and J (joining) gene segments constituting the variable domain of the heavy chain and only V and J genes for building up the variable domain of the light chain. The rearrangement of the variable region follows a strict order. The following processes that participate in the generation of antibody diversity were summarized—allelic, combinational, and junctional diversity, pairing of IgH and IgL, and receptor editing—which all together produce the primary antigen repertoire (pre-antigen stimulation). When a B cell encounters a foreign antigen, affinity maturation and class switch are induced. Thereby the antibody repertoire increases. The resulting secondary immunoglobulin repertoire reveals in humans at least 1011 specificities for different antigens.",book:{id:"5784",slug:"antibody-engineering",title:"Antibody Engineering",fullTitle:"Antibody Engineering"},signatures:"Oliver Backhaus",authors:[{id:"177685",title:"M.Sc.",name:"Oliver",middleName:null,surname:"Backhaus",slug:"oliver-backhaus",fullName:"Oliver Backhaus"}]},{id:"61204",title:"Polymorphisms",slug:"polymorphisms",totalDownloads:2005,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptible to diseases, and respond to drug, vaccine, chemical, and pathogen. It occurs more often than mutations (frequency ≥ 1%). The common polymorphism is single nucleotide polymorphism (SNP) which is a single base change in a DNA sequence that occurs most commonly in the human genome. 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In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. 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