\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"Milestone",originalUrl:"/media/original/124"}},components:[{type:"htmlEditorComponent",content:'
Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"2999",leadTitle:null,fullTitle:"Low Carbon Policy and Development in Taiwan",title:"Low Carbon Policy and Development in Taiwan",subtitle:null,reviewType:"peer-reviewed",abstract:"Taiwan a typical small Asian country with few energy resources is well known for its high-tech industry in the last 20 years. However as a member of the global village Taiwan feels the responsibility to reduce carbon emissions. The book tells you how Taiwan transforms itself from a high-tech island to become a low carbon island. The book address Taiwan's low-carbon developmental policies of the past 10 years, applies an econometric approach to estimate Taiwan's sector department CO2 emissions, shows how environmental change affects the economic growth of Taiwan, and provides two successful examples of low-carbon pilot regions in Taiwan. Stephen Shen, the Minister of the Environment Protection Agency of Taiwan, believes that the book arrives at the right time, because this is the time to educate the people of Taiwan, about the necessary action for achieving a low carbon society.",isbn:null,printIsbn:"978-953-51-0156-7",pdfIsbn:"978-953-51-6122-6",doi:"10.5772/3323",price:119,priceEur:129,priceUsd:155,slug:"low-carbon-policy-and-development-in-taiwan",numberOfPages:110,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"2abc07a1ed7ad3702df9c3a1e288ecf0",bookSignature:"Li-Fang Chou and Liang-Feng Lin",publishedDate:"February 24th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/2999.jpg",numberOfDownloads:10279,numberOfWosCitations:5,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:11,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 3rd 2012",dateEndSecondStepPublish:"January 24th 2012",dateEndThirdStepPublish:"April 29th 2012",dateEndFourthStepPublish:"July 28th 2012",dateEndFifthStepPublish:"August 27th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"127748",title:"Dr.",name:"Liang-Feng",middleName:null,surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin",profilePictureURL:"https://mts.intechopen.com/storage/users/127748/images/5379_n.jpg",biography:"Dr Liang-Feng Lin is Vice Director of Green Energy Finance Research Center and Associate Professor of Accounting at National Chengchi University, Taipei, Taiwan. He received the bachelor degree in Accounting at National Chengchi University (Taipei), the master degree in Accounting, Chengchi University (Taipei) and Temple University (USA), respectively, and the doctor degree at \nEconomics at Temple University. Besides various academic positions at the university, including Secretary General of Center for Public & Business Administration Education and Director of Learning Research Center, Dr Lin serves as Independent Board Director at South China Insurance Company. He has worked two large-scale national projects with Professor Li-Fang Chou in energy economics and management from National Science Council and Ministry of Education.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"National Chengchi University",institutionURL:null,country:{name:"Taiwan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"282170",title:"Dr.",name:"Li-Fang",middleName:null,surname:"Chou",slug:"li-fang-chou",fullName:"Li-Fang Chou",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"780",title:"Ecological Engineering",slug:"ecological-engineering"}],chapters:[{id:"26809",title:"Energy Saving and Carbon Reduction Policy in Taiwan",doi:"10.5772/39299",slug:"energy-saving-and-carbon-reduction-policy-in-taiwan",totalDownloads:1580,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Yi-Cheng Ho and Jenn-Shyong Kuo",downloadPdfUrl:"/chapter/pdf-download/26809",previewPdfUrl:"/chapter/pdf-preview/26809",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null},{id:"26810",title:"Renewable Energy Feed-in-Tariff System Design and Experience in Taiwan",doi:"10.5772/39300",slug:"renewable-energy-feed-in-tariff-system-design-and-experience-in-taiwan",totalDownloads:2227,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Li-Fang Chou and Liang-Feng Lin",downloadPdfUrl:"/chapter/pdf-download/26810",previewPdfUrl:"/chapter/pdf-preview/26810",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null},{id:"26811",title:"Assessment of the Decoupling of GHGs and Electricity Costs Through the Development of Low-Carbon Energy Technology in Taiwan",doi:"10.5772/39301",slug:"assessment-of-the-decoupling-of-ghgs-and-electricity-costs-through-the-development-of-low-carbon-ene",totalDownloads:1296,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Chien-Ming Lee and Heng-Chi Liu",downloadPdfUrl:"/chapter/pdf-download/26811",previewPdfUrl:"/chapter/pdf-preview/26811",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null},{id:"26812",title:"Estimation of Taiwan’s CO2 Emissions Related to Fossil Fuel Combustion - A Sectoral Approach",doi:"10.5772/39302",slug:"estimation-of-taiwan-s-co2-emissions-related-to-fossil-fuel-combustion-a-sectoral-approach",totalDownloads:2247,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Shinemay Chen, Der-Cherng Lo and Huai Hsuan Yu",downloadPdfUrl:"/chapter/pdf-download/26812",previewPdfUrl:"/chapter/pdf-preview/26812",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null},{id:"26813",title:"A Preliminary Look at the Relationship Between Environmental Change and Economic Growth in Taiwan",doi:"10.5772/39303",slug:"a-preliminary-look-at-the-relationship-between-environmental-change-and-economic-growth-in-taiwan",totalDownloads:1370,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Kuang-Ta Lo and Ya-Ting Yang",downloadPdfUrl:"/chapter/pdf-download/26813",previewPdfUrl:"/chapter/pdf-preview/26813",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null},{id:"26814",title:"Low-Carbon Pilot Tour and Municipal Government Investment: Taiwan’s Experience",doi:"10.5772/39304",slug:"low-carbon-pilot-tour-and-municipal-government-investment-taiwan-s-experience",totalDownloads:1559,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Liang-Feng Lin",downloadPdfUrl:"/chapter/pdf-download/26814",previewPdfUrl:"/chapter/pdf-preview/26814",authors:[{id:"127748",title:"Dr.",name:"Liang-Feng",surname:"Lin",slug:"liang-feng-lin",fullName:"Liang-Feng Lin"}],corrections:null}],productType:{id:"3",title:"Monograph",chapterContentType:"chapter",authoredCaption:"Authored by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2190",title:"Biomass Now",subtitle:"Sustainable Growth and Use",isOpenForSubmission:!1,hash:"f8a1a12b5516a184685e6421805ff25d",slug:"biomass-now-sustainable-growth-and-use",bookSignature:"Miodrag Darko Matovic",coverURL:"https://cdn.intechopen.com/books/images_new/2190.jpg",editedByType:"Edited by",editors:[{id:"27708",title:"Dr.",name:"Miodrag Darko",surname:"Matovic",slug:"miodrag-darko-matovic",fullName:"Miodrag Darko Matovic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3138",title:"Biomass Now",subtitle:"Cultivation and Utilization",isOpenForSubmission:!1,hash:"14aa4b6c2eb974aad5a2839688220b04",slug:"biomass-now-cultivation-and-utilization",bookSignature:"Miodrag Darko Matovic",coverURL:"https://cdn.intechopen.com/books/images_new/3138.jpg",editedByType:"Edited by",editors:[{id:"27708",title:"Dr.",name:"Miodrag Darko",surname:"Matovic",slug:"miodrag-darko-matovic",fullName:"Miodrag Darko Matovic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3540",title:"Biodegradation",subtitle:"Engineering and Technology",isOpenForSubmission:!1,hash:"0ee069d311f4d412f6bbf7180e3a8ea4",slug:"biodegradation-engineering-and-technology",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3540.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2311",title:"Climate Change and Variability",subtitle:null,isOpenForSubmission:!1,hash:"2fb02ff1e1671367663032ec44d0cb85",slug:"climate-change-and-variability",bookSignature:"Suzanne Simard",coverURL:"https://cdn.intechopen.com/books/images_new/2311.jpg",editedByType:"Edited by",editors:[{id:"11062",title:"Prof.",name:"Suzanne",surname:"Simard",slug:"suzanne-simard",fullName:"Suzanne Simard"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1327",title:"Greenhouse Gases",subtitle:"Emission, Measurement and Management",isOpenForSubmission:!1,hash:"f810749db3ab5479aa80cd81c0509033",slug:"greenhouse-gases-emission-measurement-and-management",bookSignature:"Guoxiang Liu",coverURL:"https://cdn.intechopen.com/books/images_new/1327.jpg",editedByType:"Edited by",editors:[{id:"92642",title:"Dr.",name:"Guoxiang",surname:"Liu",slug:"guoxiang-liu",fullName:"Guoxiang Liu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2117",title:"Greenhouse Gases",subtitle:"Capturing, Utilization and Reduction",isOpenForSubmission:!1,hash:"8cf4593468574b6d25cf38dea36729b5",slug:"greenhouse-gases-capturing-utilization-and-reduction",bookSignature:"Guoxiang Liu",coverURL:"https://cdn.intechopen.com/books/images_new/2117.jpg",editedByType:"Edited by",editors:[{id:"92642",title:"Dr.",name:"Guoxiang",surname:"Liu",slug:"guoxiang-liu",fullName:"Guoxiang Liu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3570",title:"Biodegradation of Hazardous and Special Products",subtitle:null,isOpenForSubmission:!1,hash:"29ce0f4a059cb02b060a2b4082ca81e0",slug:"biodegradation-of-hazardous-and-special-products",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3570.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"449",title:"Environmental Impact of Biofuels",subtitle:null,isOpenForSubmission:!1,hash:"faa4e85fdce130eae4d51d73d23c4816",slug:"environmental-impact-of-biofuels",bookSignature:"Marco Aurélio dos Santos Bernardes",coverURL:"https://cdn.intechopen.com/books/images_new/449.jpg",editedByType:"Edited by",editors:[{id:"6625",title:"Dr.",name:"Marco Aurelio",surname:"Dos Santos Bernardes",slug:"marco-aurelio-dos-santos-bernardes",fullName:"Marco Aurelio Dos Santos Bernardes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2151",title:"Novel Approaches and Their Applications in Risk Assessment",subtitle:null,isOpenForSubmission:!1,hash:"b37b8b1a2ebbcf1d218f6d570c65f247",slug:"novel-approaches-and-their-applications-in-risk-assessment",bookSignature:"Yuzhou Luo",coverURL:"https://cdn.intechopen.com/books/images_new/2151.jpg",editedByType:"Edited by",editors:[{id:"117189",title:"Dr.",name:"Yuzhou",surname:"Luo",slug:"yuzhou-luo",fullName:"Yuzhou Luo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"76873",slug:"corrigendum-satellite-control-system-part-i-architecture-and-main-components",title:"Corrigendum: Satellite Control System: Part I - Architecture and Main Components",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/76873.pdf\r\n",downloadPdfUrl:"/chapter/pdf-download/76873",previewPdfUrl:"/chapter/pdf-preview/76873",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/76873",risUrl:"/chapter/ris/76873",chapter:{id:"72485",slug:"satellite-control-system-part-i-architecture-and-main-components",signatures:"Yuri V. Kim",dateSubmitted:"February 17th 2020",dateReviewed:"April 16th 2020",datePrePublished:"June 15th 2020",datePublished:"April 14th 2021",book:{id:"7030",title:"Satellite Systems",subtitle:"Design, Modeling, Simulation and Analysis",fullTitle:"Satellite Systems - Design, Modeling, Simulation and Analysis",slug:"satellite-systems-design-modeling-simulation-and-analysis",publishedDate:"April 14th 2021",bookSignature:"Tien Nguyen",coverURL:"https://cdn.intechopen.com/books/images_new/7030.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"210657",title:"Dr.",name:"Tien M.",middleName:"Manh",surname:"Nguyen",slug:"tien-m.-nguyen",fullName:"Tien M. Nguyen"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316140",title:"Dr.",name:"Yuri",middleName:null,surname:"Kim",fullName:"Yuri Kim",slug:"yuri-kim",email:"yurikim@hotmail.ca",position:null,institution:{name:"Canadian Space Agency",institutionURL:null,country:{name:"Canada"}}}]}},chapter:{id:"72485",slug:"satellite-control-system-part-i-architecture-and-main-components",signatures:"Yuri V. Kim",dateSubmitted:"February 17th 2020",dateReviewed:"April 16th 2020",datePrePublished:"June 15th 2020",datePublished:"April 14th 2021",book:{id:"7030",title:"Satellite Systems",subtitle:"Design, Modeling, Simulation and Analysis",fullTitle:"Satellite Systems - Design, Modeling, Simulation and Analysis",slug:"satellite-systems-design-modeling-simulation-and-analysis",publishedDate:"April 14th 2021",bookSignature:"Tien Nguyen",coverURL:"https://cdn.intechopen.com/books/images_new/7030.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"210657",title:"Dr.",name:"Tien M.",middleName:"Manh",surname:"Nguyen",slug:"tien-m.-nguyen",fullName:"Tien M. Nguyen"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316140",title:"Dr.",name:"Yuri",middleName:null,surname:"Kim",fullName:"Yuri Kim",slug:"yuri-kim",email:"yurikim@hotmail.ca",position:null,institution:{name:"Canadian Space Agency",institutionURL:null,country:{name:"Canada"}}}]},book:{id:"7030",title:"Satellite Systems",subtitle:"Design, Modeling, Simulation and Analysis",fullTitle:"Satellite Systems - Design, Modeling, Simulation and Analysis",slug:"satellite-systems-design-modeling-simulation-and-analysis",publishedDate:"April 14th 2021",bookSignature:"Tien Nguyen",coverURL:"https://cdn.intechopen.com/books/images_new/7030.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"210657",title:"Dr.",name:"Tien M.",middleName:"Manh",surname:"Nguyen",slug:"tien-m.-nguyen",fullName:"Tien M. Nguyen"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11594",leadTitle:null,title:"Melanoma - Standard of Care, Challenges, and Updates in Clinical Research",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tPrognosis has dramatically changed for melanoma patients within the last fifteen years, after incorporating immunotherapy and targeted therapies into the treatment arsenal. Melanoma is probably the tumor that has achieved the greatest benefit from immunotherapy, considerable improving responses, and survival. These novel therapies have also been gradually added to the adjuvant setting. In addition, clinical research is assessing new treatment combinations, treatments with different mechanisms of action, and different routes of administration, being melanoma one of the most suitable diseases to test intratumoral therapies. However, some important challenges and questions remain unanswered, as to which is the best treatment sequence depending on tumor burden and molecular features, or whether any biomarker (either immunohistochemistry, gene analysis, or imaging biomarkers) may have predictive value to select the most effective treatment.
\r\n\r\n\tThis book will perform an overview on how the history of melanoma has changed and will review main treatment guidelines, focusing on main challenges we still face, to finish with a discussion regarding upcoming treatments and those which are still under clinical trials.
\r\n\t
The vast majority of persons with Autism Spectrum Disorders are highly moral but can show aggression of a non-lethal severity. Nevertheless there are a small number of persons with Autism or Asperger\'s Syndrome who do show lethal violence. I have described these as Criminal Autistic Psychopathy [11]. The rate of these problems in special hospitals and prisons is almost twice the general population prevalence of Autism and Asperger\'s Syndrome. Originally, these conditions were called Autistic Psychopathy by Hans Asperger 1938 and 1944. [9] I am suggesting that we bring back the diagnosis of Autistic Psychopathy for those persons with Autism and Asperger\'s Syndrome who engage in criminal activities with the new diagnosis Criminal Autistic Psychopathy. These persons have the dual features of Autism and Psychopathy. The seriousness of this condition is often missed with the sole diagnosis of Autism or Asperger\'s Syndrome. There are overlapping features but also differences from General Psychopathy as described in these examples of school killers in the literature.
In relation to the school shooting at Sandyhook School, Solomon (214) noted that from his conversation with Peter Lanza that his son Adam who shot 26 people at his school showed poor eye contact, problems with social relationships, preservation of sameness, narrow interests, poor communication skills and sensory issues. These are the classic features of Asperger\'s Syndrome DSM IV or the sub group of Asperger\'s Syndrome called Criminal Autistic Psychopathy [11].
Father [16] p.38) described him as showing "social awkwardness" and one of his psychiatrists Robert King [16] p.39) noted that he declined "to shake hands" when he met him. Adam was extremely controlling and dominating and had very little capacity for social reciprocity. He became very withdrawn and isolated as he grew up. Father said [16] p.40) that his son "was not open to therapy" and "did not want to talk about problems". Poor concentration is central to Asperger\'s Syndrome and Criminal Autistic Psychopathy. He showed problems in that area. He had major empathy deficits in relation to other people. According to [16] when his mother "asked Adam whether he would feel sad if anything happened to her, he replied "no". He found it much easier to communicate online. It\'s online that the true state of affairs of people with dangerous thoughts and fantasies particularly those with Asperger\'s Syndrome, Criminal Autistic Psychopathy sub type can be noticed. He felt hostile to people particularly females. On his computer he wrote "why females are inherently selfish" [16] misogynism is very common in these conditions. Father [16] states that "Adam would have killed me in a heartbeat, if he\'d had the chance". He shot his mother "four times". [16].
In relation to social relationships the State Attorney [16] stated that he "was more likely to be victimised than to act in violence against another". This is usually what happens to people with Asperger\'s Syndrome. He once asked his father "why do you need friends?" [16].
[16] describes him as showing "sclerotic orderliness". He found changing classes during the school day very stressful. His psychiatrist King also noted that "if mother walks in front of him in the kitchen, he would insist she re-do it" [16]. He had evidence of OCD and according to [16] "washed his hands excessively".
He would spend hours playing with lego with his brother [16] and indeed "invented his own board games". [16]. He wrote violent stories. [16]. He was "fascinated with guns and with the second world war, and showed an interest in joining the military". [16]. He became pre-occupied with "mass murder". [16] and "left a photograph of himself with a gun to his head". [16]. He created his own private autistic world. He loved hi-tech matters and "was a member of his school hi-tech club". [16]. Mother tried to fit in with his special interests for example taking him to the shooting range. She did her best. His interest in violence was best seen in his essays and online.
He showed poor eye contact and the psychiatrist Robert King described him as "pale, gaunt, awkward, young, adolescent standing rigidly with downcast gaze". [16].
He suffered from sensory overload, which of course made school much more difficult for him. [16] noted that he "showed hyper-sensitivity to physical touch that tags had to be removed from his clothing and "sometimes he smelled things that weren\'t there". I don\'t agree with this as he had hyper-sensitivity to smell and could smell things that the average person would be unable to do so. In relation to visual hyper-sensitivity "colour graphics" upset him. [16]. He probably also had clumsiness with a "stiff lumbering gait” [16]. His father stated that he had an "awkward walk" [16] pointed out that he was "intolerant of his mother brushing by his chair and objected to her new high heels, high heel boots, because they were "too loud". This was according to psychiatrist King.
King [16] also noted that he "had relatively little spontaneous speech but he responded in a flat tone with little inflection and almost mechanical prosody". And when King asked about his three wishes he replied "that whatever was granting the wishes would not exist".
He suffered from anxiety and depression and was prescribed Lexopro an anti-depressant but got side effects and stopped it. Father described him as suffering from "uncomfortable anxiety" [16]. He had negative thinking, low self-esteem and mother noticed that "he was exhausted and lethargic all day" and had a "sense of hopelessness". [16]. He was tearful and his mother described his "escalating misery". [16].
He was a bright boy nevertheless school was experienced as a challenge for him both socially and academically which led to some home schooling. He was an autodidact. There was evidence of symptoms of Attention Deficit Disorder in terms of poor concentration. He showed poor school progress and his mother reported that he was in despair "when faced with some course work in German" [16]. Nevertheless he set himself very high standards.
Eric had Criminal Autistic Psychopathy with a Narcissistic Personality and Depression.
He was a highly intelligent child. He loved fishing with his father and loved the quietness of the mountains and lake. He was very visual and had a keen appreciation of landscape and appreciated the effect of light on water and in particular loved "water". [5]. [5] describes a neighbour\'s comment on Eric that he was "nice, polite, preppy, and a dork". [5] noted that "his hand was always shooting up in a class and he always had the right answer". Page 9. He was highly intelligent and of course in the long term this increased his dangerousness. He was also described as being "painfully shy". [5]. He had surgery for "pectus excabatum, an abnormally sunken sternum". [5]. This was a narcissistic wound for him as a child. Eric was "gifted analytically, excellent at maths, a technology expert and into "gadgets, computers, video games". [5]. Here again we see some overlap between General Psychopathy and Criminal Autistic Psychopathy. Cullen notes that a Little League Team mate described Eric as the "shyest out of everybody" and was restricted in what he said. His coach [5] noted that "he didn’t want to miss (a ball). He didn’t want to fail" and therefore he was very slow to swing a bat. This again shows his narcissistic vulnerability and his fear of missing which he found humiliating. In a way according to [5] Eric "scripted Columbine, as a made for TV murder". [5]. This is further evidence of his narcissism and in fantasy he re-enacted the pleasure of the massacre endlessly in the long period leading up to it. In his own mind he was the superior one, the man who was awesome and frightened the world.
[5] noted that "Eric wanted to be remembered". He certainly left his mark on the sands of time. He wanted to be feared and wanted to be in a position where nobody ever looked down on him again.
The FBI analyst who examined his motives suggested that Harris was a classical psychopath and had a "messianic level superiority complex and hoped to illustrate his massive superiority to the world". Immelmann (2009) described Eric as possessing a "malignant narcissism… a Pathological Narcissistic Personality Disorder with borderline and anti-social features, also with some paranoid traits and unconstrained aggression". Eric wrote according to [5] that "my belief is that if I say something, it goes. I am the law. If you don’t like it, you die". [5] summarised Fuseliers opinion that "Eric had a preposterously grand superiority complex, a revulsion for authority, an excruciating need for control". This was largely inherent in Eric with huge innate factors and again we see the overlap with Criminal Autistic Psychopathy. Eric also stated "I feel like God and I am higher than almost anyone in the fucking world in terms of universal intelligence". [5]. This was not psychosis but it is close to psychosis.
Eric also said that "Zeus and I also get angry easily and punish people in unusual ways". [5]. In a way Zeus was one of the superior Gods. After Eric was arrested for the breaking into the car he switched from being an "observer to enforcer". [5]. This was a critical life event and even though he was the perpetrator he understood it himself as that he was the victim and how dare they arrest him and put him in handcuffs. This speeded up his sense of injustice, his hatred of humanity and simply accelerated his wish to do the massacre. Of course he was on that path before he was arrested. Eric "fancied himself as a non-conformist, but he craved approval and fumed over the neighbour\'s disrespect". [5]. Eric was hypersensitive to any rejection or criticism and [5] noted that Eric had "a long list of betrayals, an actual "shit list" on his computer of despicable young girls". He talked a lot about people who "knifed… him in the back". Most of this was more imaginary than real. Nevertheless it was psychologically very real to him.
Eric stated on one occasion "I hate almost everyone" and ah yes "I wanna rip his head off and eat it" in a "flat voice". [5]. After a fishing trip he talked about going back to "shithead society populated by automatons too dense to comprehend what was out there". [5]. Eric also wrote "if you have a problem with my thoughts, come and tell me and I\'ll kill you" [5]. Another one of his rants was "I hate". [5]. According to [5] p.216 Eric\'s "only internal struggle concerned which stupid bastards was more deserving of his wrath". He saw himself as an avenging God. Before the massacre of course he was a petty criminal. [5]) noted that Eric "savoured the idea (of) heroic opportunities to obliterate alien hoards. His dreams were riddled with gunfire and explosions" and "he was always dazzled by fire". Eric made "death threats" to another student. [5] p.88. Eric wrote on his website that he wanted to "mow down" the people of his area and that "I don’t care if I live or die in the shootout..."all I want to do is kill and injure as many of you pricks as I can". [5] p.216. [5] p. 219 notes that Eric "described going to some random downtown area....and blowing up and shooting up everything he could. He assured us he would feel no remorse, no sorrow, no shame. He would make them pay". This shows an incredibly deep hatred of the human race and he did not have a traumatic childhood. Again we are dealing with a personality and with problems largely coming from inside him.
In 1998 he wrote in a notebook "I hate the fucking world" and that "I am not respected". [5]. This was a largely paranoid thought and not based on reality. Eric also stated that "human beings were pathetic fuckheads too dense to perceive their lifeless existence...automatons" and people were "assembly-line robots". In a way Eric wanted to destroy humanity in the world. In addition Eric "had a grander vision. All his writing alluded to a wider slaughter; killing everything, destroying the human race" and he also wrote "kill them all. Well if you have not figured it out yet, I\'d say "kill mankind". [5].
[5] states that girls found him "cute" and that "he\'d always hated his appearance". Eric also could be charming and told a great deal of lies. He did not suffer from guilt for his actions. [5] noted that his Principal in college Frank de Angelis noted that Harris was "the type of kid who, when he was in front of adults, he\'d tell you what you wanted to hear". Cullen also noted that a classmate had "the impression... (that Eric) wanted to be an outcast. He was also described as "moody and aggressive". P. 140. He suffered from depression. Eric was "egotistical, empathy-free". [5]. When Eric was asked to describe himself in filing out a questionnaire which focused on distrust etc., he described himself as agreeing with some of the following descriptions: jealous "anxiety, suspiciousness, temper, obsessive thoughts, mood swings, disorganised thoughts, homicidal thoughts" [5]. When mental health professionals assessed him he seethed "as he scrawled out his answers" and he considered "the nerve of these low lifes judging him" and how he "hated fools telling him what to do." [5]. In addition, Eric was "a dreamer" of "a world where the rest of us had been removed". [5]. [5] described Harris as a "cold-blooded, predatory psychopath". Fusilier [5] noted that Eric showed "cold rational calculation-(was) charming, callous, cunning, manipulative, comically grandiose, egocentric, with appalling failures of empathy". He had the capacity when he wanted to to fool people and deceive people and was a superb liar and he was also a sensation seeker and novelty seeker. Therapy for persons with psychopathy often makes them better at psychopathy and improves their destructive social skills. He was in therapy but only pretended to engage himself from it. He was "unemotional" and was extremely dominating and controlling. [5].
He was well able to manage adults and to tell adults what they wanted to know and what they wanted to hear. His parents described him earlier as "getting angry all the time.at almost anything he didn’t like" and he would "punch a wall" [5].
Eric wrote [5] that "guns! boy, I loved playing guns". He was also superb at violent video games. He used to sketch "medieval armour and sub-machine guns" and would draw "victims (who) were frequently on fire and freshly decapitated" as well as he showed a great interest in the Nazis and their activities. [5], p.81. Another great interest was in "explosives". [5]. He loved to make home made bombs. Other interests included "Nietzsche, Freud, Hitler" and he used to say "Sich Heil" or "Heil Hitler". He was obsessed with massacres and mayhem on television.
Eric was a boy who "smoked, drank, dated" (page 6 [5] and he would walk up to "hotties in the Mall". "He won them over with quick wit, dazzling dimples and a disarming smile". [5]. Nothing could be further from Asperger\'s Syndrome than this. This was his genuine evidence of an element of General Psychopathy.
[5] stated that when "somebody needed to take control. Eric was your man. He was like a robot under pressure". The local Pizza Store where he worked had a particularly good opinion of his capabilities and put him "in charge when he left". [5]. He had excellent management skills and found it very easy to manage his co-killer Dylan Klebold.
In writing there was often contradictions and Eric\'s writing wasn’t always logical. Eric had excellent social know how compared to Dylan. Dylan and Eric had major empathy deficits and were both hostile and somewhat paranoid people. Both suffered from depression. They became a most dangerous murderous couple. Eric was the active one the leader and Dylan was the follower the passive one. They played out their killing in fantasy many times before they carried it out. The warning signs were mainly in their writings and on their website. Nevertheless they both had contact with the police. Clearly if teachers read the kind of essays that they write and their pre-occupations from now on they should take these writings very seriously and take action on them.
Dylan was described by his parents as an "introverted and has grown up isolated" and is "often angry or sullen and his behaviours seemed disrespectful to and intolerant of others". [5]. Dylan [5] was "born brilliant" and went to school "a year early" and was sent to a gifted child programme because he was "a maths prodigy". Everybody said he was extremely shy. He was extremely sensitive to criticism and could have meltdowns that could take quite a while for him to recover from. He had very vulnerable self-esteem and criticism would easily lead to a meltdown.
[5] points out that Dylan Klebold was "meek, self-conscious and shy. He could barely speak in front of a stranger, especially a girl. He\'d follow quietly after Eric (co-mass killer) on the Mall conquests attempting to appear invisible". Eric flattered "girls" with compliments; "Dylan passed them chips, cookies to let them know he liked them. Dylan\'s friends said he had never been on a date; he may never have asked a girl out". Not surprising Dylan wrote in 1997 "I feel so lonely without a friend". [5]. Dylan was a loner, which caused him pain and "felt cut off from humanity". [5] Dylan described himself as someone who had "no girl (friends)/not even platonic, no other friends, nobody accepting him, doing badly in sports, looking ugly and acting shy, getting bad grades, having no friends in life". [5]. Dylan did at times regard other humans as "zombies" and wrote about himself "I am God compared to some of these un-existable brainless zombies". [5]. This was projection and shows that he had some grandiosity as well which is often hidden behind low self-esteem.
He was very naive and tended to be caught if he did anything wrong. This is typical of persons with Autism. He was caught when he broke into a car and stole stuff with his friend Eric Harris (co-mass killer). According to [5] "Dylan Klebold was not a man of action. He was conscripted by a boy who was". Persons with Asperger\'s Syndrome are very easily led. They are often led into serious crime by other people particularly persons with psychopathy like Eric Harris. He shared talents with Eric Harris including great mathematical ability, technological expertise and in particular Dylan was excellent at "analysing, inventing, deconstructing". [5]. Dylan would hammer at "ideas relentlessly". [5]. Dylan wanted to become a specialist in computing technology and there was no doubt he would have achieved that if he hadn’t met Eric Harris.
Dylan was very interested in "classical philosophers and renaissance literature". [5]. Dylan was into polarities and felt himself to be split in his mind. One of the polarities that fascinated him was "good and bad". This was a major focus for him [5]. [5] that "Dr Fuselier from the FBI stated that "both boys fantasised about murder, but Dylan focused on a single attack".
[5] points out that Dylan did believe in God but that he would "cry out, cursing God for making him a modern Job, demanding an explanation for the divine brutality of his faithful servant. It\'s hardly surprising he considered suicide as a way out. Dylan wrote that "God had chosen him" as someone "in search of answers, never finding them, yet in hopelessness understands things. He seeks knowledge of the unthinkable, of the undefinable, of the unknown. He explores everything/using his mind, the most powerful tool known to him". [5].
Dylan had fantasies about relationships with a girl which were very powerful. He suffered from depression which is very typical with Autism indeed he wrote "good God I hate my life, I want to die really bad right now". [5]. He also had preservation of sameness and was very much a routine driven boy.
When Dylan hacked into the school computer he was caught and reprimanded. [5] wrote that when Dylan was "caught scratching obscenities into a freshman\'s locker, he was called before the school Dean and went ballistic. He cussed the Dean and bounced off the walls" and acted bizzarely.
Dylan had acting potential which was really one area where he was superior to Eric Harris his leader. It is well known [11] that many great actors had Autism or Asperger\'s Syndrome. [5] noted that on film Dylan "unleashed his anger and he was that crazy man disintegrating in front of the camera. His eyes bulged out". It was also noticed that in life generally he was not very capable and was not given complex tasks to do.
Overall he had no ability to plan an operation on his own like the massacre and was simply led in a very naive way by a person with psychopathy Eric Harris.
Cho Seung-Hui the mass killer at Virginia Tech also had a diagnosis of Autism. He was a shy, withdrawn child who had problems with social know how and social cop on. He hated hugging as a child and was very violent. He was clingy to his mother. He showed poor communication and often gave one word answers to questions. He great aunt [2] stated that "when others called his name he just answered yes or no but never showed any feelings or emotions. We started to worry he was autistic". Later he was formally diagnosed with Autism. He was bullied within the educational system.
A Professor Lucinda Roy complained to the campus police about him and she also gave him "individual lessons" and said to him: "You seem so lonely"-"Do you have any friends?". "I am lonely". Cho replied. "I don’t have any friends". A student at Virginia Tech Karen Grewal [17] noted that "he was so quiet, it was almost as if he wasn’t there and was invisible. He must have been worried that he\'d would be found out".
[3] noted that there were "college girls who reported him to the police for stalking and got him carted off to a mental hospital after he sent them shy love messages full of meaning". Cho [3] also wrote "by a name, I know not how to tell who I am". This is typical of the identity diffusion of autism. He was unable to get a girlfriend and "he had to make up with a fantasy girlfriend". [3]. He was a loner as a child. [2] notes that a fellow student noted he was "obsessed with violence and with serious personal problems". He admired the Columbine killers. Professor Nikki Giovanni one of his teachers at Virginia Tech was concerned about his writing i.e. "your bra is torn and I am looking at your flesh". [3]. He\'d never speak but he frightened everyone. According to [17] "he insisted on wearing sunglasses and pulling his baseball cap low on his forehead" and that neighbours "described him as a surly youth who did not communicate and ignored them in the street". He was a major mathematical talent like many with Autism. [9]. Professor Louis Schlesginger a Professor of Forensic Psychology states that "mass killers tend to be aggrieved, hurt, clinically depressed, socially isolated and above all paranoid". (Begley 2007).
In the psychiatric hospital in 2007 a psychiatrist noted his "affect is flat and mood is depressed". (Begley 2007).
School shootings and mass killings are not uncommonly committed by persons with neurodevelopmental disorders i.e. Criminal Autistic Psychopathy/Asperger\'s Syndrome with often a good deal of warning based on writings on the internet and elsewhere.
Botulinum neurotoxins (BoNTs) are the most potent protein toxins among bacterial, animal, plant and chemical toxic compounds and are the cause of botulism [1]. However, BoNT-based therapeutics are widely used for treatment of various diseases and esthetic disorders. Various features of BoNT pharmacology holding a great promise for development of both BoNT-based therapeutics and anti-botulinic agents are currently studied. Unique molecular mechanisms underlying various stages of botulinum neurotoxin type A pharmacological activity as well as potential factors affecting body sensitivity to BoNT are described herein.
Botulinum neurotoxin is a protein dimer with molecular weight of 150 kDa and chemical formula C6760H10447N1743O2010S32 consisting of two chains: light and heavy [1]. The light chain represents approximately one third of toxin molecular weight and is bound to the heavy one with a disulfide link [2].
The light chain (L-chain) is a protease blocking synaptic release. It forms the BoNT molecule catalytic domain. The heavy chain (H-chain) consists of two domains: binding domain bounds to target cell surface receptors, translocation domain is involved in light chain translocation creating cell membrane channel. The BoNT molecule is a dipole with an electric charge attenuating from the binding domain to the catalytic one [3]. It is of importance when the molecule is directed relative to cell membrane that facilitates receptor binding.
In natural settings BoNTs are synthesized by bacteria as a complex with several proteins: one non-toxic non-hemagglutinin (NTNHA) and several hemagglutinins [1].
NTNHA has a molecular weight of 130 kDa and its amino acid sequences are highly homologous to BoNT but without protease motif as the only difference. “Hand in glove”-type interaction with the BoNT molecule protects the one from aggressive effects of environmental factors including GIT proteolytic enzymes [4].
There are three classes of hemagglutinins with molecular weight of 33–35, 15–18 and 70 kDa [5]. They do not contact with the BoNT molecule directly but with NTNHA working as an adhesin molecule when such toxin complex is absorbed.
Non-toxic hemagglutinin and hemagglutinin proteins can form various multimeric complexes with BoNT called botulinum neurotoxin complexes. Each of them contains only one BoNT molecule released from the complex if medium pH changes [2].
BoNTs can enter human body via both injured and intact tissues. Therapeutically botulinum neurotoxin type-A (BoNT/A) based agents are mainly injected as close as possible to their target cells. However, BoNT/A forms to be applied without the need to damage skin are already under development though they are not yet through Phase III clinical studies [6, 7].
In natural settings BoNTs show systemic action causing botulism and enter the body mainly through intact membranes.
Depending on toxin mode of entry botulism forms can be classified as follows: food botulism (ingestion of BoNT-contaminated food), infant (ingestion of food with bacteria spores), inhalation (breathing-in BoNT-containing aerosols), wound (in majority of cases it is related to injectable drug use), iatrogenic [8].
In natural settings botulinum neurotoxin should cross epithelial barriers and reach general circulation to hit its target cells. Such process is called absorption.
BoNT might utilize two modes of penetrating intestinal or pulmonary epithelium: intracellular route and intercellular junction-related one.
In case of transcytosis (penetration through epithelial cell) BoNT binds to ganglioside receptors at epithelial cell surface and undergoes endocytosis (being captured in a vesicle). Transport vesicles transfer toxin through the whole cell and release it into general circulation. Neither toxin structure is altered, nor it is released in cell cytosol during transcytosis, which differentiates BoNT binding with epithelial cell from binding with neuronal ones [9, 10].
Paracellular route (through intercellular junctions) may or may not involve complexing proteins. Complexin hemagglutinins can bind to E-cadherin in epithelial intercellular junctions and disrupts the latter allowing BoNT in general circulation [4]. However, BoNT molecules are able to break epithelial barriers without complexing proteins. Studies by Maksymowych et al. [11] and Al-Saleem et al. [12] showed that introduction of equimolar amounts of free BoNT/A and BoNT/A complexes resulted in equivalent BoNT titers in general circulation with similar toxicity and effectiveness. However, hemagglutinins are assumed to boost BoNT transportation through epithelium.
When transported through intestinal wall BoNT may bind to cholinergic and serotoninergic neurons of enteral (intestinal) nervous system located in intestinal submucosa blocking gut motor and secretory activity. It explains impaired bowel movement (constipation) as one of early signs for alimentary and infant botulism [13].
BoNT penetrating epithelial barrier reaches general circulation and is distributed in all extracellular fluid compartments in the body but the ones of central nervous system.
Eisele et al. [14] had a series of experiments demonstrating that with pH values close to neutral (arterial blood pH of 7.37–7.43 [15, 16]) botulinum neurotoxin complex dissociates on active BoNT and complexing proteins with half-life below 1 minute. Once such toxin complex dissociates complexing proteins are not any more of any significance for the occurrence of the clinical effect of BoNT.
Al-Saleem et al. [17] works proved that toxin reaches general circulation without any evident structural or biological activity changes. General circulation performs as toxin storage compartment until BoNT reaches its target cells. While in general circulation BoNT undergoes slight biotransformation, it is not accumulated in blood cells and mostly remains in its free active form. Such concept of “general circulation—botulinum neurotoxin storage compartment” has been confirmed by many researchers. Fagan et al. [18] described active BoNT/A presence in human blood serum 11 days after contaminated food ingestion; Sheth et al. [19], 25 days after disease onset; Delbrassinne et al. [20], 29 days after contaminated food was taken.
From intravascular fluid compartment botulinum neurotoxin enters extravascular one and then intercellular fluid. Being locally injected with therapeutic purposes botulinum neurotoxin is directly introduced in extravascular compartment (or intravascular one if it is in a blood vessel) next to target cells bypassing absorption stage. From intercellular compartment botulinum neurotoxin should reach its target—peripheral cholinergic nerve endings and bind to receptors there.
To better understand the mechanism of botulinum neurotoxin binding with receptors knowledge of normal neurotransmission in synapses is required.
Neuromediators are synthesized in neuron cytosol and then stored in pre-synaptic nerve endings within synaptic vesicles. Synaptic vesicle membrane contains proton pump (vesicular ATPase), which, when activated, increases intravesicular proton concentration [8]. Electrochemical proton gradient ensures mediator influx from cytosol and its accumulation in such vesicles. The uptake of mediators within the synaptic vesicles is also regulated by receptors on the neuronal membrane, not only by the proton gradient. Mediator-containing vesicles are located in neuron cytoplasm and are bound to specific presynaptic membrane regions (active zones [21]) during so-called docking [22]. Vesicles are docked with cell membrane in active zones only and docking is controlled by a great deal of transport proteins [23].
When a nerve impulse arrives axonal presynaptic membrane is depolarized, calcium channels open and Ca2+ ions flow into axon [24]. In response to Ca2+ influx the mediator-containing vesicle fuses with presynaptic membrane in active zone. This stage is called priming. It is regulated with two integral membrane synaptic vesicle proteins (synaptobrevin and synaptotagmin) as well as two presynaptic membrane proteins (SNAP25 and syntaxin) and cytosol proteins including complexin [25, 26, 27, 28].
Rapid vesicle conformation changes by regulatory proteins result in full synaptic vesicle fusion with presynaptic membrane and pore formation wherethrough neuromediator is released in a synaptic cleft [29].
Neuromediator diffuses from its nerve terminal and binds to post-synaptic receptors that trigger post-synaptic cell signaling. In neuromuscular junctions acetyl choline binds with its receptor on myocyte plasmalemma resulting in muscle cell membrane depolarization. Membrane depolarization kicks off Ca2+ influx in myocyte and muscle contraction.
While neuromediator is released synaptic vesicle lumen opens temporarily into a synaptic cleft but later it internalizes in nerve terminal during endocytosis. After endocytosis the vesicle is again filled in with neuromediator and next neurotransmission cycle starts [30].
Active BoNT/A molecules bind with target cells via their receptors on cell surface [31]. To bind with neuronal membrane BoNT/A molecule should interact with a set of high and low affinity receptors [32]. Currently three receptors (polysyaloganglioside GT1b, fibroblast growth factor receptor 3, transmembrane vesicular receptor SV2) and several co-receptors have been described with such combination.
Active neurotoxin molecule endocytosis and its further changes are possible only once it binds with entire receptor combination at axonal surface [5]. Binding to one of the receptors without interaction with others does not induce toxin internalization. Such multistage process for BoNT/A binding with receptors makes up for low BoNT/A concentration in circulating fluids, high rate of extracellular flow around cells and small axonal surface area.
First BoNT/A receptor at neuronal surface is polysyaloganglioside GT1b (PSG).
Gangliosides are glycosylated lipids being a part of cell membranes. Though gangliosides are present in all tissues of vertebrates they are more prevalent in neuronal membranes [33] where they are involved in optimal myelin production, axon-myelin interactions, peripheral and central axon stability [32].
PSG density on presynaptic membrane is high. PSGs are grouped as microdomains next to presynaptic membrane active zones [34]. PSG receptor presence in these zones is important for processes of botulinum neurotoxin binding with other receptors.
Oligosaccharide (BoNT-binding part) PSG projects quite far outside membrane surface in a synaptic gap and is negatively charged [8]. BoNT/A molecule is a dipole with positively charged binding domain [3]. Such electric charge difference of BoNT/A binding domain and PSG receptors (and other anion lipids at axonal membrane) makes possible to redirect BoNT/A molecule on its way to cell membrane enhancing receptor binding chances.
Currently polysyaloganglioside are considered as initial binding regions drawing toxin from relatively vast 3D extracellular fluid space into 2D membrane surface one [5]. It is required, in turn, for toxin binding to following receptors. On one hand, binding to PSG is irreversible since BoNT/A is extracted from ground substance and is fixed on axonal membrane. On the other, at that stage toxin can still be affected and neutralizing antibodies can still reach it.
However, polysyalogangliosides are membrane receptors for both botulinum neurotoxin and human neuropathy-associated antiganglioside autoantibodies. Anti-PSG autoantibody production in neuropathy patients may induce diminished botulinum neurotoxin sensitivity and resistance development [35].
HC subdomain structure of botulinum neurotoxin type A is homologous to basic fibroblast growth factor (FGF) [36]. That similarity enables BoNT/A high-affinity binding with protein fibroblast growth factor receptor 3 (FGFR3b) on neuronal surface [37].
However, FGFR3b receptors are affine not only to BoNT/A but also to multiple fibroblast growth factors. Moreover, this receptor affinity to growth factors exceeds the one to botulinum neurotoxin. Native FGFR3 ligands—growth factors FGF1, FGF2 and FGF9—compete for binding with FGFR3 and occupying receptors are able to jam BoNT/A absorption by cells [8].
Besides, FGFR3b receptor activity is regulated by several low-affinity cofactors including heparansulfate, neuropilin-1, anosmin, etc. [38]. Non-specificity and competitive binding of FGFR3 receptors with BoNT/A and fibroblast growth factors, cofactor impact on receptor activity may explain fragility of the said receptor mechanism and, therefore, variable sensitivity to botulinum neurotoxin. Moreover, some FGFR3 mutation-related conditions (skeletal dysplasias, epidermal nevus, seborrheic keratosis, hyperinsulinemia) might demonstrate defective FGFR3 expression [39, 40, 41, 42, 43]. FGFR3 mutation influence on botulinum neurotoxin sensitivity is yet to be studied.
SV2 is a protein receptor located on vesicular membrane [44] of all peripheral and central neurons as well as on secretory granule membrane of endocrine cells [45]. SV2 is expressed on vesicular membranes in cells accumulating not only acetyl choline but also GABA, dopamine, glutamate, substance P and several other mediators [46].
Unlike polysyaloganglioside receptors expressed into a synaptic gap the SV2-receptor BoNT/A-binding site is projected into synaptic vesicle lumen and is not approachable for neurotoxin while such vesicle is in axonal cytosol [47]. SV2 becomes reachable for BoNT/A at the time of vesicle fusion with presynaptic membrane and acetyl choline exocytosis [48].
Thus, BoNT/A binding with entire receptor combination happens in active zones only after synaptic vesicle fusion with presynaptic membrane and opening of vesicular lumen into synaptic cleft facilitating further BoNT/A endocytosis. After binding with receptor combination and endocytosis botulinum neurotoxin cannot be reached by neutralizing antibodies anymore.
BoNT/A molecule binding with receptors results in receptor-mediated endocytosis of both receptors and toxin [49].
Immediately after endocytosis vesicular lumen has neutral pH. Vesicular ATPase proton pump controls mediator re-uptake [50] and injects protons into synaptic vesicle, therefore, gradually decreasing vesicular lumen pH [51].
Vesicular medium acidification results in irreversible conformation changes of both heavy and light BoNT/A chains. With these changes the heavy chain being linked via receptors with vesicular membrane forms transmembrane H-channel there [52, 53]. Through the channel the conformation-altered light chain leaves the vesicle for cytosol [54] and then chain-binding disulfide link breaks up.
L-chain translocation occurs with pH between 4.5 and 6 [55]. pH decrease results in protonation of carboxylated amino acid residues present in BoNT/A heavy and light chains. Carboxylated residues are located at one side of toxin molecule and their protonation results in significant changes of molecular shape [55]. BoNT/A molecule with its positively charged surface interacts with anion vesicular membrane surface forming protein and lipid complex [56]. L-chain is assumed to turn into “molten protein globule” gaining hydrophobic features [8]. On one hand, L-chain hydrophobicity ensures its translocation via the H-chain-formed membrane channel. On the other, with lower pH molecular surface where the disulfide bond is located becomes more hydrophobic. It ensures disulfide bond integrity until complete L-chain translocation.
To cross vesicular membrane L-chain should have disulfide bond with H-chain throughout entire translocation sequence [55]. Premature disulfide bond breakage at any stage until it exits into cytosol interrupts L-chain translocation [57].
At the end of translocation process the disulfide bond is destroyed by thioredoxin reductase-thioredoxin system releasing light chain to express its catalytic activity in cytosol [58].
Thioredoxin reductase (TrxR)—thioredoxin (Trx) system is a main cellular redox system. TrxR and Trx are cytosol side proteins of vesicular membrane and their inhibition may block BoNT/A action on stages when neurotoxin cannot be reached by neutralizing antibodies [59]. In vitro experiments of Zanetti et al. [60] showed that inhibitors for TrxR-Trx enzymatic couple hampers L-chain protease activity for all known botulinum neurotoxin serotypes in cultured neurons. While in vivo they prevent toxin-induced paralysis in mice irrespective of botulinum neurotoxin serotype.
In terms of life cycle model disulfide bond reduction is the end of intracellular existence of intact active BoNT/A molecule (holotoxin). Even if a light or heavy chain was exported out of cell none of them on its own should be able to disrupt cell functioning. Only holotoxin can undergo through multiple stages ended up with conduction block [61]. On the other side, conformation changes related to pH-induced L-chain translocation in cytosol create “a trap” making impossible both retrotranslocation into endosome and active toxin molecule return in extracellular environment [5].
Modified L-chain enters neuron cytosol through H-channel where it behaves as a metalloprotease. It catalytically cleaves nine amino acids from C-terminal of soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) for SNAP25 protein (SNAP25206) forming SNAP25197 [62, 63]. Intact SNAP25 is required for mediator-containing vesicle attachment with further neurotransmitter release and it is also involved directly in Ca-channels activity regulation in presynaptic membrane [64]. SNAP25 cleavage impairs mediator exocytosis causing nerve impulse conduction block and muscle paralysis [65].
Synaptic activity is highly sensitive to cleavage of minimal SNAP25 amounts. It was hypothesized that SNAP25 in neuron cytosol exists as various pools and that only small amounts of SNAP25 are actively involved in exocytosis and reachable for L-protease effects [66]. It was confirmed experimentally showing that cleavage of 10–15% of total intracellular SNAP25 pool is sufficient for complete neuromediator release block [67, 68, 69]. L-protease cleavage of as little as 2–3% of SNAP25 pool results in block of miniature post-synaptic cell potentials (weak depolarization of post-synaptic membranes at neuromuscular rest) [70].
Along with that SNAP25 proteolysis product, SNAP25197 protein, on its own inhibits exocytosis [71]. Meunier et al [72]. described that SNAP25197 is able to persist for a long while in cytosol as a component of the non-productive SNARE complex prolongating BoNT/A effects. While removal of several amino acids from SNAP25197 results in rapid exocytosis restoration.
Zinc is necessary for light chain catalytic activity. One botulinum holotoxin molecule contains 1 zinc atom retained by L-chain zinc-binding amino acid sequence and such binding is reversible [73].
Vesicle acidification causes protonation of zinc-binding sections in the BoNT molecule. Translocation causes light chain denaturation obliterating chelate site integrity. As a result bound zinc dissociates and adds up to cytosol zinc pool.
Simpson et al [74]. in their in vitro studies demonstrated that zinc removal from active botulinum neurotoxin molecule caused L-chain catalytic activity loss in cell-free samples. Though activity in intact neuromuscular junctions retained since internalized toxin bound cytosol zinc. Thus, zinc retained by holotoxin (intact active molecule) is not the same zinc that is bound with catalytically active light chain. Light chain binds cytosol zinc.
Main BoNT/A target is peripheral neurons where botulinum neurotoxin inhibits acetylcholine release [75].
Many of cell-based studies showed that BoNT/A not only blocks acetylcholine release but also prevents release of multiple other neuromediators if they are accumulated and stored in vesicles [32]. These neuromediators are as follows: epinephrine, norepinephrine, dopamine [76, 77], glutamate [78], glycine [79], serotonin [80], substance P [81], etc. Therefore, botulinum neurotoxin is to be considered not as specific acetylcholine release inhibitor but rather as an exocytosis blocker for various mediators that offers tremendous promise for treatment and prevention of various disorders.
In addition, BoNT/A can affect cells not only as a blocker of exocytosis mediators, but also by binding to various receptors on the cell membrane, cause specific biological effects. Including influencing the expression of genes by the cell. Grando and Zachary [82] described that many cells are capable of expressing one or more BoNT/A receptors and binding BoNT/A: epidermal keratinocytes, mesenchymal stem cells from subcutaneous adipose tissue, nasal mucosa cells, urothelium, intestinal epithelial cells, prostate epithelial cells, alveolar epithelial cells, neutrophils, macrophages, etc. In addition to SNAP25, BoNT/A can also cleave SNAP-23, which is expressed in various human tissues.
Kim et al. [83] experimentally proved that BoNT/A is able to bind to TLR2 receptors on macrophages, changing the expression of genes responsible for signal transduction, protein metabolism and modification, nucleic acid metabolism, apoptosis, proliferation, cell differentiation. Which may explain the anti-inflammatory effect of BoNT/A.
Cytotoxicity for BoNT/A has not been established either in cell-based studies [84] or in electrophysiological studies in healthy humans [85]. In addition, the experience of therapeutic use of BoNT/A for various indications indicates the absence of any signs of neuronal damage even with long-term regular use [66, 86, 87].
Further studies of unique pharmacological mechanisms for botulinum neurotoxin are quite promising for the search of the ways to influence its effects: to extend/shorten its action duration, to increase/decrease BoNT sensitivity in specific patient populations. Also it will help to develop protocols for optimal combinations of botulinum neurotoxin with esthetic medicine procedures of all kinds. Better insights on multiple aspects of not only BoNT neuronal selectivity but also BoNT/A interaction with non-neuronal cells will show ways to find new therapeutic applications of botulinum neurotoxin-based agents in various areas of medicine.
One of the promising areas of botulinum therapy and bioengineering of botulinum toxin is the treatment of pain syndromes. BoNT/A is effective in the treatment of various neuropathic pain syndromes, including chronic migraine, postherpetic neuralgia, trigeminal neuralgia and peripheral neuralgia [32].
Hybrid preparations of botulinum toxin are being developed to suppress secretion in various cell populations, including the secretion of growth hormone [88]. Various effects of BoNT/A on the enhancement and suppression of gene expression in neuronal and non-neuronal cells are described [89]. This implies a fundamentally different response of neuronal and epithelial cells to the action of botulinum toxin and is of great importance in the development of anti-cancer treatments based on BoNT/A.
Thus, BoNT/A should not be considered as a specific blocker of acetylcholine release by motor neurons, but mainly as a blocker of exocytosis of various mediators by various cells, neuronal and non-neuronal. Moreover, the biological effect of BoNT/A can be realized not only through the blockade of exocytosis. And it can be absolutely different in different types of cells, which has great prospects in the treatment and prevention of many diseases.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
",metaTitle:"Publishing Process Steps and Descriptions",metaDescription:"This is a brief overview of the main steps involved in publishing with InTechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Publishing Process Manager who will be your single point of contact and lead you through all the described steps below.",metaKeywords:null,canonicalURL:"page/publishing-process-steps",contentRaw:'[{"type":"htmlEditorComponent","content":"1. SEND YOUR PROPOSAL
\\n\\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\\n\\n2. SUBMIT YOUR MANUSCRIPT
\\n\\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\\n\\n3. PEER REVIEW RESULTS
\\n\\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\\n\\n4. ACCEPTANCE AND PRICE QUOTE
\\n\\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\\n\\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\\n\\nWe will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\\n\\nAt this step you will also be asked to accept the Copyright Agreement.
\\n\\n5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\\n\\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\\n\\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\\n\\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\\n\\n6. INVOICE PAYMENT
\\n\\nThe invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\\n\\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\\n\\n7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\\n\\nIntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\\n\\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. SEND YOUR PROPOSAL
\n\nPlease complete the publishing proposal form. The completed form should serve as an overview of your future Compacts, Monograph or Edited Book. Once submitted, your publishing proposal will be sent for evaluation, and a notice of acceptance or rejection will be sent within 10 to 30 working days from the date of submission.
\n\n2. SUBMIT YOUR MANUSCRIPT
\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
\n\n3. PEER REVIEW RESULTS
\n\nExternal reviewers will evaluate your manuscript and provide you with their feedback. You may be asked to revise your draft, or parts of your draft, provide additional information and make any other necessary changes according to their comments and suggestions.
\n\n4. ACCEPTANCE AND PRICE QUOTE
\n\nIf the manuscript is formally accepted after peer review you will receive a formal Notice of Acceptance, and a price quote.
\n\nThe Open Access Publishing Fee of your IntechOpen Compacts, Monograph or Edited Book depends on the volume of the publication and includes: project management, editorial and peer review services, technical editing, language copyediting, cover design and book layout, book promotion and ISBN assignment.
\n\nWe will send you your price quote and after it has been accepted (by both the author and the publisher), both parties will sign a Statement of Work binding them to adhere to the agreed upon terms.
\n\nAt this step you will also be asked to accept the Copyright Agreement.
\n\n5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\n\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\n\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\n\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n6. INVOICE PAYMENT
\n\nThe invoice is generally paid by the author, the author’s institution or funder. The payment can be made by credit card from your Author Panel (one will be assigned to you at the beginning of the project), or via bank transfer as indicated on the invoice. We currently accept the following payment options:
\n\nIntechOpen will help you complete your payment safely and securely, keeping your personal, professional and financial information safe.
\n\n7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
\n\nIntechOpen authors can choose whether to publish their book online only or opt for online and print editions. IntechOpen Compacts, Monographs and Edited Books will be published on www.intechopen.com. If ordered, print copies are delivered by DHL within 12 to 15 working days.
\n\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6654},{group:"region",caption:"Middle and South America",value:2,count:5945},{group:"region",caption:"Africa",value:3,count:2452},{group:"region",caption:"Asia",value:4,count:12681},{group:"region",caption:"Australia and Oceania",value:5,count:1014},{group:"region",caption:"Europe",value:6,count:17701}],offset:12,limit:12,total:133951},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"21"},books:[{type:"book",id:"11434",title:"Indigenous Populations - Perspectives From Scholars and Practitioners in Contemporary Times",subtitle:null,isOpenForSubmission:!0,hash:"c0d1c1c93a36fd9d726445966316a373",slug:null,bookSignature:"Dr. Sylvanus Gbendazhi Barnabas",coverURL:"https://cdn.intechopen.com/books/images_new/11434.jpg",editedByType:null,editors:[{id:"293764",title:"Dr.",name:"Sylvanus",surname:"Barnabas",slug:"sylvanus-barnabas",fullName:"Sylvanus Barnabas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11436",title:"Beauty - Evolutionary, Social and Cultural Perspectives on Attractiveness",subtitle:null,isOpenForSubmission:!0,hash:"8f2773e5d4ffe767f38dd15712258e8c",slug:null,bookSignature:"Dr. Farid Pazhoohi",coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",editedByType:null,editors:[{id:"470837",title:"Dr.",name:"Farid",surname:"Pazhoohi",slug:"farid-pazhoohi",fullName:"Farid Pazhoohi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11443",title:"Empathy - Advanced Research and Applications",subtitle:null,isOpenForSubmission:!0,hash:"4c1042dfe15aa9cea6019524c4cbff38",slug:null,bookSignature:"Ph.D. Sara Ventura",coverURL:"https://cdn.intechopen.com/books/images_new/11443.jpg",editedByType:null,editors:[{id:"227763",title:"Ph.D.",name:"Sara",surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11444",title:"Happiness - Biopsychosocial and Anthropological Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"fa84e7fc3611e5428e070239dcf5a93f",slug:null,bookSignature:"Dr. Floriana Irtelli and Prof. Fabio Gabrielli",coverURL:"https://cdn.intechopen.com/books/images_new/11444.jpg",editedByType:null,editors:[{id:"174641",title:"Dr.",name:"Floriana",surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11478",title:"Recent Advances in the Study of Dyslexia",subtitle:null,isOpenForSubmission:!0,hash:"26764a18c6b776698823e0e1c3022d2f",slug:null,bookSignature:"Prof. Jonathan Glazzard",coverURL:"https://cdn.intechopen.com/books/images_new/11478.jpg",editedByType:null,editors:[{id:"294281",title:"Prof.",name:"Jonathan",surname:"Glazzard",slug:"jonathan-glazzard",fullName:"Jonathan Glazzard"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11777",title:"LGBT Communities",subtitle:null,isOpenForSubmission:!0,hash:"e08bb222c250dcebf093b7ab595a14a7",slug:null,bookSignature:"Dr. Deborah Woodman",coverURL:"https://cdn.intechopen.com/books/images_new/11777.jpg",editedByType:null,editors:[{id:"463750",title:"Dr.",name:"Deborah",surname:"Woodman",slug:"deborah-woodman",fullName:"Deborah Woodman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11781",title:"Family Therapy - Recent Advances in Clinical and Crisis Settings",subtitle:null,isOpenForSubmission:!0,hash:"8c5b7d5e4233594de70d2f830209b757",slug:null,bookSignature:"Dr. Oluwatoyin Olatundun Ilesanmi",coverURL:"https://cdn.intechopen.com/books/images_new/11781.jpg",editedByType:null,editors:[{id:"440049",title:"Dr.",name:"Oluwatoyin Olatundun",surname:"Ilesanmi",slug:"oluwatoyin-olatundun-ilesanmi",fullName:"Oluwatoyin Olatundun Ilesanmi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11782",title:"Personality Traits - The Role in Psychopathology",subtitle:null,isOpenForSubmission:!0,hash:"d3a491e5194cad4c59b900dd57a11842",slug:null,bookSignature:" Vladimir V. Kalinin",coverURL:"https://cdn.intechopen.com/books/images_new/11782.jpg",editedByType:null,editors:[{id:"31572",title:null,name:"Vladimir V.",surname:"Kalinin",slug:"vladimir-v.-kalinin",fullName:"Vladimir V. Kalinin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11783",title:"Motivation and Success",subtitle:null,isOpenForSubmission:!0,hash:"f660b7cd35b9af94bdfc3564df138161",slug:null,bookSignature:"Dr. Simon George Taukeni",coverURL:"https://cdn.intechopen.com/books/images_new/11783.jpg",editedByType:null,editors:[{id:"202046",title:"Dr.",name:"Simon George",surname:"Taukeni",slug:"simon-george-taukeni",fullName:"Simon George Taukeni"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12109",title:"Identifying Occupational Stress and Coping Strategies",subtitle:null,isOpenForSubmission:!0,hash:"09a2f5fe50b90b20637b7aceccf1cfdd",slug:null,bookSignature:"Dr. Kavitha Palaniappan",coverURL:"https://cdn.intechopen.com/books/images_new/12109.jpg",editedByType:null,editors:[{id:"311189",title:"Dr.",name:"Kavitha",surname:"Palaniappan",slug:"kavitha-palaniappan",fullName:"Kavitha Palaniappan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12127",title:"The Psychology of Sports",subtitle:null,isOpenForSubmission:!0,hash:"4bf52abfe589a320744c40ca5fe41a89",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12127.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12135",title:"Parenting",subtitle:null,isOpenForSubmission:!0,hash:"5fcfe3872ea161c9c879e0667a220ca8",slug:null,bookSignature:"",coverURL:"//cdnintech.com/web/frontend/www/assets/cover.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:40},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:66},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:26},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:124},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:8},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:10},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:14},popularBooks:{featuredBooks:[{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10787",title:"Hepatocellular Carcinoma",subtitle:"Challenges and Opportunities of a Multidisciplinary Approach",isOpenForSubmission:!1,hash:"bc00a66513e51003e5dbbc0294e0fc3d",slug:"hepatocellular-carcinoma-challenges-and-opportunities-of-a-multidisciplinary-approach",bookSignature:"Georgios Tsoulfas",coverURL:"https://cdn.intechopen.com/books/images_new/10787.jpg",editors:[{id:"57412",title:"Prof.",name:"Georgios",middleName:null,surname:"Tsoulfas",slug:"georgios-tsoulfas",fullName:"Georgios Tsoulfas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,isOpenForSubmission:!1,hash:"4e868cde273d65a7ff54b1817d640629",slug:"hydrolases",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",isOpenForSubmission:!1,hash:"2c628f4757f9639a4450728d839a7842",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",bookSignature:"Xianquan Zhan",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10193",title:"Multidisciplinary Experiences in Renal Replacement Therapy",subtitle:null,isOpenForSubmission:!1,hash:"3c4738671bb3e815744d1e04df7ba879",slug:"multidisciplinary-experiences-in-renal-replacement-therapy",bookSignature:"Ane C.F. Nunes",coverURL:"https://cdn.intechopen.com/books/images_new/10193.jpg",editors:[{id:"55270",title:"Prof.",name:"Ane",middleName:null,surname:"Claudia Fernandes Nunes",slug:"ane-claudia-fernandes-nunes",fullName:"Ane Claudia Fernandes Nunes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10983",title:"Conifers",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"3e524d29fc3f95c3389efbd41463dab6",slug:"conifers-recent-advances",bookSignature:"Ana Cristina Gonçalves and Teresa Fonseca",coverURL:"https://cdn.intechopen.com/books/images_new/10983.jpg",editors:[{id:"194484",title:"Prof.",name:"Ana Cristina",middleName:null,surname:"Gonçalves",slug:"ana-cristina-goncalves",fullName:"Ana Cristina Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10539",title:"Ginseng",subtitle:"Modern Aspects of the Famed Traditional Medicine",isOpenForSubmission:!1,hash:"5f388543a066b617d2c52bd4c027c272",slug:"ginseng-modern-aspects-of-the-famed-traditional-medicine",bookSignature:"Christophe Hano and Jen-Tsung Chen",coverURL:"https://cdn.intechopen.com/books/images_new/10539.jpg",editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10881",title:"Drug Repurposing",subtitle:"Molecular Aspects and Therapeutic Applications",isOpenForSubmission:!1,hash:"eca3f2d5ca97b457d38a2442b36d3ac7",slug:"drug-repurposing-molecular-aspects-and-therapeutic-applications",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4423},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2204,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",publishedDate:"June 15th 2022",numberOfDownloads:1182,editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10787",title:"Hepatocellular Carcinoma",subtitle:"Challenges and Opportunities of a Multidisciplinary Approach",isOpenForSubmission:!1,hash:"bc00a66513e51003e5dbbc0294e0fc3d",slug:"hepatocellular-carcinoma-challenges-and-opportunities-of-a-multidisciplinary-approach",bookSignature:"Georgios Tsoulfas",coverURL:"https://cdn.intechopen.com/books/images_new/10787.jpg",publishedDate:"June 15th 2022",numberOfDownloads:1006,editors:[{id:"57412",title:"Prof.",name:"Georgios",middleName:null,surname:"Tsoulfas",slug:"georgios-tsoulfas",fullName:"Georgios Tsoulfas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10841",title:"Hydrolases",subtitle:null,isOpenForSubmission:!1,hash:"4e868cde273d65a7ff54b1817d640629",slug:"hydrolases",bookSignature:"Sajjad Haider, Adnan Haider and Angel Catalá",coverURL:"https://cdn.intechopen.com/books/images_new/10841.jpg",publishedDate:"June 15th 2022",numberOfDownloads:863,editors:[{id:"110708",title:"Dr.",name:"Sajjad",middleName:null,surname:"Haider",slug:"sajjad-haider",fullName:"Sajjad Haider"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10797",title:"Cell Culture",subtitle:"Advanced Technology and Applications in Medical and Life Sciences",isOpenForSubmission:!1,hash:"2c628f4757f9639a4450728d839a7842",slug:"cell-culture-advanced-technology-and-applications-in-medical-and-life-sciences",bookSignature:"Xianquan Zhan",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",publishedDate:"June 15th 2022",numberOfDownloads:793,editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10193",title:"Multidisciplinary Experiences in Renal Replacement Therapy",subtitle:null,isOpenForSubmission:!1,hash:"3c4738671bb3e815744d1e04df7ba879",slug:"multidisciplinary-experiences-in-renal-replacement-therapy",bookSignature:"Ane C.F. Nunes",coverURL:"https://cdn.intechopen.com/books/images_new/10193.jpg",publishedDate:"June 15th 2022",numberOfDownloads:730,editors:[{id:"55270",title:"Prof.",name:"Ane",middleName:null,surname:"Claudia Fernandes Nunes",slug:"ane-claudia-fernandes-nunes",fullName:"Ane Claudia Fernandes Nunes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2167,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10983",title:"Conifers",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"3e524d29fc3f95c3389efbd41463dab6",slug:"conifers-recent-advances",bookSignature:"Ana Cristina Gonçalves and Teresa Fonseca",coverURL:"https://cdn.intechopen.com/books/images_new/10983.jpg",publishedDate:"June 15th 2022",numberOfDownloads:600,editors:[{id:"194484",title:"Prof.",name:"Ana Cristina",middleName:null,surname:"Gonçalves",slug:"ana-cristina-goncalves",fullName:"Ana Cristina Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10539",title:"Ginseng",subtitle:"Modern Aspects of the Famed Traditional Medicine",isOpenForSubmission:!1,hash:"5f388543a066b617d2c52bd4c027c272",slug:"ginseng-modern-aspects-of-the-famed-traditional-medicine",bookSignature:"Christophe Hano and Jen-Tsung Chen",coverURL:"https://cdn.intechopen.com/books/images_new/10539.jpg",publishedDate:"June 15th 2022",numberOfDownloads:583,editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10881",title:"Drug Repurposing",subtitle:"Molecular Aspects and Therapeutic Applications",isOpenForSubmission:!1,hash:"eca3f2d5ca97b457d38a2442b36d3ac7",slug:"drug-repurposing-molecular-aspects-and-therapeutic-applications",bookSignature:"Shailendra K. Saxena",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg",publishedDate:"June 1st 2022",numberOfDownloads:2231,editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10774",title:"Model Organisms in Plant Genetics",subtitle:null,isOpenForSubmission:!1,hash:"f6624b58571ac10c9b636c5d85ec5e54",slug:"model-organisms-in-plant-genetics",bookSignature:"Ibrokhim Y. Abdurakhmonov",coverURL:"https://cdn.intechopen.com/books/images_new/10774.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"213344",title:"Prof.",name:"Ibrokhim Y.",middleName:null,surname:"Abdurakhmonov",slug:"ibrokhim-y.-abdurakhmonov",fullName:"Ibrokhim Y. Abdurakhmonov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10839",title:"Protein Detection",subtitle:null,isOpenForSubmission:!1,hash:"2f1c0e4e0207fc45c936e7d22a5369c4",slug:"protein-detection",bookSignature:"Yusuf Tutar and Lütfi Tutar",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10696",title:"Applications of Calorimetry",subtitle:null,isOpenForSubmission:!1,hash:"8c87f7e2199db33b5dd7181f56973a97",slug:"applications-of-calorimetry",bookSignature:"José Luis Rivera Armenta and Cynthia Graciela Flores Hernández",coverURL:"https://cdn.intechopen.com/books/images_new/10696.jpg",editedByType:"Edited by",publishedDate:"June 23rd 2022",editors:[{id:"107855",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Rivera Armenta",slug:"jose-luis-rivera-armenta",fullName:"Jose Luis Rivera Armenta"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"991",title:"Herbalism",slug:"herbalism",parent:{id:"172",title:"Complementary Medicine",slug:"complementary-medicine"},numberOfBooks:14,numberOfSeries:0,numberOfAuthorsAndEditors:462,numberOfWosCitations:396,numberOfCrossrefCitations:293,numberOfDimensionsCitations:720,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"991",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10539",title:"Ginseng",subtitle:"Modern Aspects of the Famed Traditional Medicine",isOpenForSubmission:!1,hash:"5f388543a066b617d2c52bd4c027c272",slug:"ginseng-modern-aspects-of-the-famed-traditional-medicine",bookSignature:"Christophe Hano and Jen-Tsung Chen",coverURL:"https://cdn.intechopen.com/books/images_new/10539.jpg",editedByType:"Edited by",editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10926",title:"Traditional Plant-Based Forms of Treatment of Fungal Infections in Suriname",subtitle:"Phytochemical and Pharmacological Rationale",isOpenForSubmission:!1,hash:"6e1a574ef8f9d3d79e4f6b22d4d44d91",slug:"traditional-plant-based-forms-of-treatment-of-fungal-infections-in-suriname-phytochemical-and-pharmacological-rationale",bookSignature:"Dennis R.A. Mans",coverURL:"https://cdn.intechopen.com/books/images_new/10926.jpg",editedByType:"Edited by",editors:[{id:"193905",title:"Dr.",name:"Dennis",middleName:"R. A.",surname:"R.A. Mans",slug:"dennis-r.a.-mans",fullName:"Dennis R.A. Mans"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"4",chapterContentType:"chapter",authoredCaption:"Authored by"}},{type:"book",id:"10907",title:"Herbs and Spices",subtitle:"New Processing Technologies",isOpenForSubmission:!1,hash:"f95ecdf9c56db9567aa29b880dba5836",slug:"herbs-and-spices-new-processing-technologies",bookSignature:"Rabia Shabir Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10907.jpg",editedByType:"Edited by",editors:[{id:"239057",title:"Dr.",name:"Rabia Shabir",middleName:null,surname:"Ahmad",slug:"rabia-shabir-ahmad",fullName:"Rabia Shabir Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6994",title:"Tea",subtitle:"Chemistry and Pharmacology",isOpenForSubmission:!1,hash:"e6241cd52834161ac64d4a7b2a812796",slug:"tea-chemistry-and-pharmacology",bookSignature:"Gonçalo Justino",coverURL:"https://cdn.intechopen.com/books/images_new/6994.jpg",editedByType:"Edited by",editors:[{id:"76687",title:"Dr.",name:"Gonçalo",middleName:null,surname:"Justino",slug:"goncalo-justino",fullName:"Gonçalo Justino"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9108",title:"Medicinal Plants",subtitle:"Use in Prevention and Treatment of Diseases",isOpenForSubmission:!1,hash:"7d0c52af195da3322be63610d6567019",slug:"medicinal-plants-use-in-prevention-and-treatment-of-diseases",bookSignature:"Bassam Abdul Rasool Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/9108.jpg",editedByType:"Edited by",editors:[{id:"155124",title:"Dr.",name:"Bassam",middleName:"Abdul Rasool",surname:"Hassan",slug:"bassam-hassan",fullName:"Bassam Hassan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6302",title:"Herbal Medicine",subtitle:null,isOpenForSubmission:!1,hash:"b70a98c6748d0449a6288de73da7b8d9",slug:"herbal-medicine",bookSignature:"Philip F. Builders",coverURL:"https://cdn.intechopen.com/books/images_new/6302.jpg",editedByType:"Edited by",editors:[{id:"182744",title:"Dr.",name:"Philip",middleName:null,surname:"Builders",slug:"philip-builders",fullName:"Philip Builders"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5612",title:"Aromatic and Medicinal Plants",subtitle:"Back to Nature",isOpenForSubmission:!1,hash:"ccf7987200bfc541e2e56bb138de86f3",slug:"aromatic-and-medicinal-plants-back-to-nature",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/5612.jpg",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5494",title:"Chinese Medical Therapies for Diabetes, Infertility, Silicosis and the Theoretical Basis",subtitle:null,isOpenForSubmission:!1,hash:"7b3b6a2700d7fd0511770bf77290a422",slug:"chinese-medical-therapies-for-diabetes-infertility-silicosis-and-the-theoretical-basis",bookSignature:"Xing-Tai Li",coverURL:"https://cdn.intechopen.com/books/images_new/5494.jpg",editedByType:"Edited by",editors:[{id:"73821",title:"Dr.",name:"Xing-Tai",middleName:null,surname:"Li",slug:"xing-tai-li",fullName:"Xing-Tai Li"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2975",title:"Complementary Therapies for the Contemporary Healthcare",subtitle:null,isOpenForSubmission:!1,hash:"604c4ba43197c3ba1506c55c763d4ca7",slug:"complementary-therapies-for-the-contemporary-healthcare",bookSignature:"Marcelo Saad and Roberta de Medeiros",coverURL:"https://cdn.intechopen.com/books/images_new/2975.jpg",editedByType:"Edited by",editors:[{id:"51991",title:"Prof.",name:"Marcelo",middleName:null,surname:"Saad",slug:"marcelo-saad",fullName:"Marcelo Saad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"542",title:"A Compendium of Essays on Alternative Therapy",subtitle:null,isOpenForSubmission:!1,hash:"a805c1d2d8449dcecd52eb7a48d2e6b1",slug:"a-compendium-of-essays-on-alternative-therapy",bookSignature:"Arup Bhattacharya",coverURL:"https://cdn.intechopen.com/books/images_new/542.jpg",editedByType:"Edited by",editors:[{id:"66982",title:"Dr.",name:"Arup",middleName:null,surname:"Bhattacharya",slug:"arup-bhattacharya",fullName:"Arup Bhattacharya"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:14,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"61866",doi:"10.5772/intechopen.76139",title:"Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants",slug:"plants-secondary-metabolites-the-key-drivers-of-the-pharmacological-actions-of-medicinal-plants",totalDownloads:8875,totalCrossrefCites:56,totalDimensionsCites:140,abstract:"The vast and versatile pharmacological effects of medicinal plants are basically dependent on their phytochemical constituents. Generally, the phytochemical constituents of plants fall into two categories based on their role in basic metabolic processes, namely primary and secondary metabolites. Primary plant metabolites are involved in basic life functions; therefore, they are more or less similar in all living cells. On the other hand, secondary plant metabolites are products of subsidiary pathways as the shikimic acid pathway. In the course of studying, the medicinal effect of herbals is oriented towards the secondary plant metabolites. Secondary plant metabolites played an important role in alleviating several aliments in the traditional medicine and folk uses. In modern medicine, they provided lead compounds for the production of medications for treating various diseases from migraine up to cancer. Secondary plant metabolites are classified according to their chemical structures into various classes. In this chapter, we will be presenting various classes of secondary plant metabolites, their distribution in different plant families and their important medicinal uses.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Rehab A. Hussein and Amira A. El-Anssary",authors:[{id:"212117",title:"Dr.",name:"Rehab",middleName:null,surname:"Hussein",slug:"rehab-hussein",fullName:"Rehab Hussein"},{id:"221140",title:"Dr.",name:"Amira",middleName:null,surname:"El-Anssary",slug:"amira-el-anssary",fullName:"Amira El-Anssary"}]},{id:"64851",doi:"10.5772/intechopen.80348",title:"Herbal Medicines in African Traditional Medicine",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14206,totalCrossrefCites:30,totalDimensionsCites:52,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",authors:[{id:"191264",title:"Prof.",name:"Josephine",middleName:"Ozioma",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",middleName:null,surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}]},{id:"54028",doi:"10.5772/67291",title:"Chemical Composition and Biological Activities of Mentha Species",slug:"chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:7474,totalCrossrefCites:13,totalDimensionsCites:46,abstract:"The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea, vomiting, anorexia, and ulcerative colitis. Furthermore, it is well documented that the essential oil and extracts of Mentha species possess antimicrobial, fungicidal, antiviral, insecticidal, and antioxidant properties. The economic importance of mints is also evident; mint oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. To provide a scientific basis for their traditional uses, several studies have been conducted to determine the chemical composition of mints and assess their biological activities. This chapter describes the therapeutic effects and uses of Mentha species and their constituents, particularly essential oils and phenolic compounds; some additional biological activities will also be considered.",book:{id:"5612",slug:"aromatic-and-medicinal-plants-back-to-nature",title:"Aromatic and Medicinal Plants",fullTitle:"Aromatic and Medicinal Plants - Back to Nature"},signatures:"Fatiha Brahmi, Madani Khodir, Chibane Mohamed and Duez Pierre",authors:[{id:"193281",title:"Dr.",name:"Fatiha",middleName:null,surname:"Brahmi",slug:"fatiha-brahmi",fullName:"Fatiha Brahmi"},{id:"199693",title:"Prof.",name:"Khodir",middleName:null,surname:"Madani",slug:"khodir-madani",fullName:"Khodir Madani"},{id:"199694",title:"Prof.",name:"Pierre",middleName:null,surname:"Duez",slug:"pierre-duez",fullName:"Pierre Duez"},{id:"203738",title:"Prof.",name:"Mohamed",middleName:null,surname:"Chibane",slug:"mohamed-chibane",fullName:"Mohamed Chibane"}]},{id:"58270",doi:"10.5772/intechopen.72437",title:"Toxicity and Safety Implications of Herbal Medicines Used in Africa",slug:"toxicity-and-safety-implications-of-herbal-medicines-used-in-africa",totalDownloads:3376,totalCrossrefCites:16,totalDimensionsCites:39,abstract:"The use of herbal medicines has seen a great upsurge globally. In developing countries, many patronize them largely due to cultural acceptability, availability and cost. In developed countries, they are used because they are natural and therefore assumed to be safer than allopathic medicines. In recent times, however, there has been a growing concern about their safety. This has created a situation of ambivalence in discussions regarding their use. Some medicinal plants are intrinsically toxic by virtue of their constituents and can cause adverse reactions if inappropriately used. Other factors such as herb-drug interactions, lack of adherence to good manufacturing practice (GMP), poor regulatory measures and adulteration may also lead to adverse events in their use. Many in vivo tests on aqueous extracts largely support the safety of herbal medicines, whereas most in vitro tests on isolated single cells mostly with extracts other than aqueous ones show contrary results and thus continue the debate on herbal medicine safety. It is expected that toxicity studies concerning herbal medicine should reflect their traditional use to allow for rational discussions regarding their safety for their beneficial use. While various attempts continue to establish the safety of various herbal medicines in man, their cautious and responsible use is required.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Merlin L.K. Mensah, Gustav Komlaga, Arnold D. Forkuo, Caleb\nFirempong, Alexander K. Anning and Rita A. Dickson",authors:[{id:"190435",title:"Dr.",name:"Caleb",middleName:null,surname:"Firempong",slug:"caleb-firempong",fullName:"Caleb Firempong"},{id:"212111",title:"Dr.",name:"Gustav",middleName:null,surname:"Komlaga",slug:"gustav-komlaga",fullName:"Gustav Komlaga"},{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",slug:"arnold-forkuo-donkor",fullName:"Arnold Forkuo Donkor"},{id:"217049",title:"Prof.",name:"Merlin Lincoln Kwao",middleName:null,surname:"Mensah",slug:"merlin-lincoln-kwao-mensah",fullName:"Merlin Lincoln Kwao Mensah"},{id:"217488",title:"Dr.",name:"Alexander K.",middleName:null,surname:"Anning",slug:"alexander-k.-anning",fullName:"Alexander K. Anning"},{id:"223959",title:"Prof.",name:"Akosua Rita",middleName:null,surname:"Dickson",slug:"akosua-rita-dickson",fullName:"Akosua Rita Dickson"}]},{id:"26489",doi:"10.5772/28224",title:"Alternative and Traditional Medicines Systems in Pakistan: History, Regulation, Trends, Usefulness, Challenges, Prospects and Limitations",slug:"alternative-and-traditional-medicines-systems-in-pakistan-history-regulation-trends-usefulness-chall",totalDownloads:9199,totalCrossrefCites:9,totalDimensionsCites:21,abstract:null,book:{id:"542",slug:"a-compendium-of-essays-on-alternative-therapy",title:"A Compendium of Essays on Alternative Therapy",fullTitle:"A Compendium of Essays on Alternative Therapy"},signatures:"Shahzad Hussain, Farnaz Malik, Nadeem Khalid, Muhammad Abdul Qayyum and Humayun Riaz",authors:[{id:"73162",title:"Dr.",name:"Shahzad",middleName:null,surname:"Hussain",slug:"shahzad-hussain",fullName:"Shahzad Hussain"},{id:"82266",title:"Dr.",name:"Farnaz",middleName:null,surname:"Malik",slug:"farnaz-malik",fullName:"Farnaz Malik"},{id:"124185",title:"Dr.",name:"Humayun",middleName:null,surname:"Riaz",slug:"humayun-riaz",fullName:"Humayun Riaz"},{id:"124186",title:"Mr.",name:"Muhammad Abdul",middleName:null,surname:"Qayyum",slug:"muhammad-abdul-qayyum",fullName:"Muhammad Abdul Qayyum"},{id:"125340",title:"Mr.",name:"Nadeem",middleName:null,surname:"Khalid",slug:"nadeem-khalid",fullName:"Nadeem Khalid"}]}],mostDownloadedChaptersLast30Days:[{id:"64851",title:"Herbal Medicines in African Traditional Medicine",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14149,totalCrossrefCites:29,totalDimensionsCites:52,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",authors:[{id:"191264",title:"Prof.",name:"Josephine",middleName:"Ozioma",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",middleName:null,surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}]},{id:"61866",title:"Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants",slug:"plants-secondary-metabolites-the-key-drivers-of-the-pharmacological-actions-of-medicinal-plants",totalDownloads:8839,totalCrossrefCites:55,totalDimensionsCites:138,abstract:"The vast and versatile pharmacological effects of medicinal plants are basically dependent on their phytochemical constituents. Generally, the phytochemical constituents of plants fall into two categories based on their role in basic metabolic processes, namely primary and secondary metabolites. Primary plant metabolites are involved in basic life functions; therefore, they are more or less similar in all living cells. On the other hand, secondary plant metabolites are products of subsidiary pathways as the shikimic acid pathway. In the course of studying, the medicinal effect of herbals is oriented towards the secondary plant metabolites. Secondary plant metabolites played an important role in alleviating several aliments in the traditional medicine and folk uses. In modern medicine, they provided lead compounds for the production of medications for treating various diseases from migraine up to cancer. Secondary plant metabolites are classified according to their chemical structures into various classes. In this chapter, we will be presenting various classes of secondary plant metabolites, their distribution in different plant families and their important medicinal uses.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Rehab A. Hussein and Amira A. El-Anssary",authors:[{id:"212117",title:"Dr.",name:"Rehab",middleName:null,surname:"Hussein",slug:"rehab-hussein",fullName:"Rehab Hussein"},{id:"221140",title:"Dr.",name:"Amira",middleName:null,surname:"El-Anssary",slug:"amira-el-anssary",fullName:"Amira El-Anssary"}]},{id:"77433",title:"Extraction of Bioactive Compounds from Medicinal Plants and Herbs",slug:"extraction-of-bioactive-compounds-from-medicinal-plants-and-herbs",totalDownloads:1236,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Human beings have relied on herbs and medicinal plants as sources of food and remedy from time immemorial. Bioactive compounds from plants are currently the subject of much research interest, but their extraction as part of phytochemical and/or biological investigations present specific challenges. Herbalists or scientists have developed many protocols of extraction of bioactive ingredients to ensure the effectiveness and the efficacy of crude drugs that were used to get relief from sickness. With the advent of new leads from plants such as morphine, quinine, taxol, artemisinin, and alkaloids from Voacanga species, a lot of attention is paid to the mode of extraction of active phytochemicals to limit the cost linked to the synthesis and isolation. Thus, the extraction of active compounds from plants needs appropriate extraction methods and techniques that provide bioactive ingredients-rich extracts and fractions. The extraction procedures, therefore, play a critical role in the yield, the nature of phytochemical content, etc. This chapter aims to present, describe, and compare extraction procedures of bioactive compounds from herbs and medicinal plants.",book:{id:"10356",slug:"natural-medicinal-plants",title:"Natural Medicinal Plants",fullTitle:"Natural Medicinal Plants"},signatures:"Fongang Fotsing Yannick Stéphane, Bankeu Kezetas Jean Jules, Gaber El-Saber Batiha, Iftikhar Ali and Lenta Ndjakou Bruno",authors:[{id:"224515",title:"Dr.",name:"Fongang Fotsing",middleName:null,surname:"Yannick Stéphane",slug:"fongang-fotsing-yannick-stephane",fullName:"Fongang Fotsing Yannick Stéphane"},{id:"227816",title:"Dr.",name:"Bankeu Kezetas",middleName:null,surname:"Jean Jules",slug:"bankeu-kezetas-jean-jules",fullName:"Bankeu Kezetas Jean Jules"},{id:"227817",title:"Prof.",name:"Lenta Ndjakou",middleName:null,surname:"Bruno",slug:"lenta-ndjakou-bruno",fullName:"Lenta Ndjakou Bruno"},{id:"349790",title:"Prof.",name:"Gaber",middleName:null,surname:"El-Saber Batiha",slug:"gaber-el-saber-batiha",fullName:"Gaber El-Saber Batiha"},{id:"357350",title:"Dr.",name:"Iftikhar",middleName:null,surname:"Ali",slug:"iftikhar-ali",fullName:"Iftikhar Ali"}]},{id:"26491",title:"Homeopathy: Treatment of Cancer with the Banerji Protocols",slug:"homeopathy-treatment-of-cancer-with-the-banerji-protocols",totalDownloads:54022,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"542",slug:"a-compendium-of-essays-on-alternative-therapy",title:"A Compendium of Essays on Alternative Therapy",fullTitle:"A Compendium of Essays on Alternative Therapy"},signatures:"Prasanta Banerji and Pratip Banerji",authors:[{id:"79939",title:"Dr",name:"Prasanta",middleName:null,surname:"Banerji",slug:"prasanta-banerji",fullName:"Prasanta Banerji"},{id:"79943",title:"Dr.",name:"Pratip",middleName:null,surname:"Banerji",slug:"pratip-banerji",fullName:"Pratip Banerji"}]},{id:"54028",title:"Chemical Composition and Biological Activities of Mentha Species",slug:"chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:7469,totalCrossrefCites:13,totalDimensionsCites:44,abstract:"The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea, vomiting, anorexia, and ulcerative colitis. Furthermore, it is well documented that the essential oil and extracts of Mentha species possess antimicrobial, fungicidal, antiviral, insecticidal, and antioxidant properties. The economic importance of mints is also evident; mint oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. To provide a scientific basis for their traditional uses, several studies have been conducted to determine the chemical composition of mints and assess their biological activities. This chapter describes the therapeutic effects and uses of Mentha species and their constituents, particularly essential oils and phenolic compounds; some additional biological activities will also be considered.",book:{id:"5612",slug:"aromatic-and-medicinal-plants-back-to-nature",title:"Aromatic and Medicinal Plants",fullTitle:"Aromatic and Medicinal Plants - Back to Nature"},signatures:"Fatiha Brahmi, Madani Khodir, Chibane Mohamed and Duez Pierre",authors:[{id:"193281",title:"Dr.",name:"Fatiha",middleName:null,surname:"Brahmi",slug:"fatiha-brahmi",fullName:"Fatiha Brahmi"},{id:"199693",title:"Prof.",name:"Khodir",middleName:null,surname:"Madani",slug:"khodir-madani",fullName:"Khodir Madani"},{id:"199694",title:"Prof.",name:"Pierre",middleName:null,surname:"Duez",slug:"pierre-duez",fullName:"Pierre Duez"},{id:"203738",title:"Prof.",name:"Mohamed",middleName:null,surname:"Chibane",slug:"mohamed-chibane",fullName:"Mohamed Chibane"}]}],onlineFirstChaptersFilter:{topicId:"991",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"23",title:"Education and Human Development",doi:"10.5772/intechopen.100360",issn:null,scope:"\r\n\tEducation and Human Development is an interdisciplinary research area that aims to shed light on topics related to both learning and development. This Series is intended for researchers, practitioners, and students who are interested in understanding more about these fields and their applications.
",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA. Dr. Stavropoulos received her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. She is the Assistant Director of the SEARCH Center at UCR and is a Faculty member in the Graduate Program in Neuroscience.",institutionString:null,institution:{name:"University of California, Riverside",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorThree:null},{id:"90",title:"Human Development",coverUrl:"https://cdn.intechopen.com/series_topics/covers/90.jpg",isOpenForSubmission:!0,editor:{id:"191040",title:"Dr.",name:"Tal",middleName:null,surname:"Dotan Ben-Soussan",slug:"tal-dotan-ben-soussan",fullName:"Tal Dotan Ben-Soussan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBf1QAG/Profile_Picture_2022-03-18T07:56:11.jpg",biography:"Tal Dotan Ben-Soussan, Ph.D., is the director of the Research Institute for Neuroscience, Education and Didactics (RINED) – Paoletti Foundation. Ben-Soussan leads international studies on training and neuroplasticity from neurophysiological and psychobiological perspectives. As a neuroscientist and bio-psychologist, she has published numerous articles on neuroplasticity, movement and meditation. She acts as an editor and reviewer in several renowned journals and coordinates international conferences integrating theoretical, methodological and practical approaches on various topics, such as silence, logics and neuro-education. She lives in Assisi, Italy.",institutionString:"Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:5,paginationItems:[{id:"82394",title:"Learning by Doing Active Social Learning",doi:"10.5772/intechopen.105523",signatures:"Anat Raviv",slug:"learning-by-doing-active-social-learning",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82310",title:"Knowledge of Intergenerational Contact to Combat Ageism towards Older People",doi:"10.5772/intechopen.105592",signatures:"Alice Nga Lai Kwong",slug:"knowledge-of-intergenerational-contact-to-combat-ageism-towards-older-people",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}},{id:"81993",title:"Emergent Chemistry: Using Visualizations to Develop Abstract Thinking and a Sense of Scale Within the Preschool Setting",doi:"10.5772/intechopen.105216",signatures:"Karina Adbo",slug:"emergent-chemistry-using-visualizations-to-develop-abstract-thinking-and-a-sense-of-scale-within-the",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82252",title:"Early Childhood: Enriched Environments and Roles of Caring Adults",doi:"10.5772/intechopen.105157",signatures:"Analía Mignaton",slug:"early-childhood-enriched-environments-and-roles-of-caring-adults",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}}]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11578",title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",hash:"3731c009f474c6ed4293f348ca7b27ac",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 3rd 2022",isOpenForSubmission:!0,editors:[{id:"225390",title:"Dr.",name:"Asghar Ali",surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12086",title:"Cattle Diseases - Molecular and Biochemical Approach",coverURL:"https://cdn.intechopen.com/books/images_new/12086.jpg",hash:"afdbf57e32d996556a94528c06623cf3",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 5th 2022",isOpenForSubmission:!0,editors:[{id:"219081",title:"Dr.",name:"Abdulsamed",surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11579",title:"Animal Welfare - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11579.jpg",hash:"12e4f41264cbe99028655e5463fa941a",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"51520",title:"Dr.",name:"Shao-Wen",surname:"Hung",slug:"shao-wen-hung",fullName:"Shao-Wen Hung"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81557",title:"Object Tracking Using Adapted Optical Flow",doi:"10.5772/intechopen.102863",signatures:"Ronaldo Ferreira, Joaquim José de Castro Ferreira and António José Ribeiro Neves",slug:"object-tracking-using-adapted-optical-flow",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",subseries:{id:"24",title:"Computer Vision"}}},{id:"81558",title:"Thresholding Image Techniques for Plant Segmentation",doi:"10.5772/intechopen.104587",signatures:"Miguel Ángel Castillo-Martínez, Francisco Javier Gallegos-Funes, Blanca E. Carvajal-Gámez, Guillermo Urriolagoitia-Sosa and Alberto J. Rosales-Silva",slug:"thresholding-image-techniques-for-plant-segmentation",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",subseries:{id:"24",title:"Computer Vision"}}},{id:"81471",title:"Semantic Map: Bringing Together Groups and Discourses",doi:"10.5772/intechopen.103818",signatures:"Theodore Chadjipadelis and Georgia Panagiotidou",slug:"semantic-map-bringing-together-groups-and-discourses",totalDownloads:19,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79491",title:"Fuzzy Perceptron Learning for Non-Linearly Separable Patterns",doi:"10.5772/intechopen.101312",signatures:"Raja Kishor Duggirala",slug:"fuzzy-perceptron-learning-for-non-linearly-separable-patterns",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Raja Kishor",surname:"Duggirala"}],book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81234",title:"Cognitive Visual Tracking of Hand Gestures in Real-Time RGB Videos",doi:"10.5772/intechopen.103170",signatures:"Richa Golash and Yogendra Kumar Jain",slug:"cognitive-visual-tracking-of-hand-gestures-in-real-time-rgb-videos",totalDownloads:38,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",subseries:{id:"24",title:"Computer Vision"}}},{id:"81331",title:"Machine Learning Algorithm-Based Contraceptive Practice among Ever-Married Women in Bangladesh: A Hierarchical Machine Learning Classification Approach",doi:"10.5772/intechopen.103187",signatures:"Iqramul Haq, Md. Ismail Hossain, Md. Moshiur Rahman, Md. Injamul Haq Methun, Ashis Talukder, Md. Jakaria Habib and Md. Sanwar Hossain",slug:"machine-learning-algorithm-based-contraceptive-practice-among-ever-married-women-in-bangladesh-a-hie",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},subseriesFiltersForOFChapters:[{caption:"Applied Intelligence",value:22,count:1,group:"subseries"},{caption:"Computer Vision",value:24,count:8,group:"subseries"},{caption:"Machine Learning and Data Mining",value:26,count:10,group:"subseries"}],publishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"9493",title:"Periodontology",subtitle:"Fundamentals and Clinical Features",coverURL:"https://cdn.intechopen.com/books/images_new/9493.jpg",slug:"periodontology-fundamentals-and-clinical-features",publishedDate:"February 16th 2022",editedByType:"Edited by",bookSignature:"Petra Surlin",hash:"dfe986c764d6c82ae820c2df5843a866",volumeInSeries:8,fullTitle:"Periodontology - Fundamentals and Clinical Features",editors:[{id:"171921",title:"Prof.",name:"Petra",middleName:null,surname:"Surlin",slug:"petra-surlin",fullName:"Petra Surlin",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:"University of Medicine and Pharmacy of Craiova",institution:{name:"University of Medicine and Pharmacy of Craiova",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9588",title:"Clinical Concepts and Practical Management Techniques in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9588.jpg",slug:"clinical-concepts-and-practical-management-techniques-in-dentistry",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Aneesa Moolla",hash:"42deab8d3bcf3edf64d1d9028d42efd1",volumeInSeries:7,fullTitle:"Clinical Concepts and Practical Management Techniques in Dentistry",editors:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",institutionURL:null,country:{name:"South Africa"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8202",title:"Periodontal Disease",subtitle:"Diagnostic and Adjunctive Non-surgical Considerations",coverURL:"https://cdn.intechopen.com/books/images_new/8202.jpg",slug:"periodontal-disease-diagnostic-and-adjunctive-non-surgical-considerations",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Nermin Mohammed Ahmed Yussif",hash:"0aee9799da7db2c732be44dd8fed16d8",volumeInSeries:6,fullTitle:"Periodontal Disease - Diagnostic and Adjunctive Non-surgical Considerations",editors:[{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",institutionString:"MSA University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8837",title:"Human Teeth",subtitle:"Key Skills and Clinical Illustrations",coverURL:"https://cdn.intechopen.com/books/images_new/8837.jpg",slug:"human-teeth-key-skills-and-clinical-illustrations",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Zühre Akarslan and Farid Bourzgui",hash:"ac055c5801032970123e0a196c2e1d32",volumeInSeries:5,fullTitle:"Human Teeth - Key Skills and Clinical Illustrations",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui",profilePictureURL:"https://mts.intechopen.com/storage/users/52177/images/system/52177.png",biography:"Prof. Farid Bourzgui obtained his DMD and his DNSO option in Orthodontics at the School of Dental Medicine, Casablanca Hassan II University, Morocco, in 1995 and 2000, respectively. Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Prosthodontics and Implant Dentistry",value:2,count:2},{group:"subseries",caption:"Oral Health",value:1,count:6}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"319576",title:"Prof.",name:"Nikolay",middleName:null,surname:"Boyadjiev",slug:"nikolay-boyadjiev",fullName:"Nikolay Boyadjiev",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v4b3cQAA/Profile_Picture_2022-06-07T08:30:58.jpeg",institutionString:null,institution:{name:"Medical University Plovdiv",institutionURL:null,country:{name:"Bulgaria"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},onlineFirstChapters:{paginationCount:34,paginationItems:[{id:"81595",title:"Prosthetic Concepts in Dental Implantology",doi:"10.5772/intechopen.104725",signatures:"Ivica Pelivan",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:22,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80963",title:"Pain Perception in Patients Treated with Ligating/Self-Ligating Brackets versus Patients Treated with Aligners",doi:"10.5772/intechopen.102796",signatures:"Farid Bourzgui, Rania Fastani, Salwa Khairat, Samir Diouny, Mohamed El Had, Zineb Serhier and Mohamed Bennani Othmani",slug:"pain-perception-in-patients-treated-with-ligating-self-ligating-brackets-versus-patients-treated-wit",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80500",title:"Novel Dental Implants with Herbal Composites: A Review",doi:"10.5772/intechopen.101489",signatures:"Gopathy Sridevi and Seshadri Srividya",slug:"novel-dental-implants-with-herbal-composites-a-review",totalDownloads:49,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"78320",title:"Implant-Retained Maxillary and Mandibular Overdentures - A Solution for Completely Edentulous Patients",doi:"10.5772/intechopen.99575",signatures:"Dubravka Knezović Zlatarić, Robert Ćelić and Hrvoje Pezo",slug:"implant-retained-maxillary-and-mandibular-overdentures-a-solution-for-completely-edentulous-patients",totalDownloads:64,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79724",title:"Implant Stability Quotient (ISQ): A Reliable Guide for Implant Treatment",doi:"10.5772/intechopen.101359",signatures:"Gaurav Gupta",slug:"implant-stability-quotient-isq-a-reliable-guide-for-implant-treatment",totalDownloads:59,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80223",title:"Bridging the Gap: Nasoalveolar Moulding in Early Cleft Palate Rehabilitation",doi:"10.5772/intechopen.101986",signatures:"Amanda Nadia Ferreira",slug:"bridging-the-gap-nasoalveolar-moulding-in-early-cleft-palate-rehabilitation",totalDownloads:71,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80186",title:"Effects of Various Dentofacial Orthopedic and Orthognathic Treatment Modalities on Pharyngeal Airway",doi:"10.5772/intechopen.101719",signatures:"Tejashri Pradhan and Aarti Sethia",slug:"effects-of-various-dentofacial-orthopedic-and-orthognathic-treatment-modalities-on-pharyngeal-airway",totalDownloads:83,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"78834",title:"Current Methods for Acceleration of Orthodontic Tooth Movement",doi:"10.5772/intechopen.100221",signatures:"Mehmet Akin and Leyla Cime Akbaydogan",slug:"current-methods-for-acceleration-of-orthodontic-tooth-movement",totalDownloads:127,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79817",title:"Peri-Implant Soft Tissue Augmentation",doi:"10.5772/intechopen.101336",signatures:"Marko Blašković and Dorotea Blašković",slug:"peri-implant-soft-tissue-augmentation",totalDownloads:123,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Marko",surname:"Blašković"},{name:"Dorotea",surname:"Blaskovic"}],book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79100",title:"Orthodontics and the Periodontium: A Symbiotic Relationship",doi:"10.5772/intechopen.100801",signatures:"Betsy Sara Thomas and Mohan Alexander",slug:"orthodontics-and-the-periodontium-a-symbiotic-relationship",totalDownloads:72,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79680",title:"Digital Workflow for Homemade Aligner",doi:"10.5772/intechopen.100347",signatures:"Dalal Elmoutawakkil and Nabil Hacib",slug:"digital-workflow-for-homemade-aligner",totalDownloads:201,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79611",title:"Growth Factors and Dental Implantology",doi:"10.5772/intechopen.101082",signatures:"Deeksha Gupta",slug:"growth-factors-and-dental-implantology",totalDownloads:103,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79584",title:"Orthodontic Management of Adult Sleep Apnea: Clinical Case Reports",doi:"10.5772/intechopen.101193",signatures:"Lahcen Ousehal, Soukaina Sahim, Hajar Bouzid, Hakima Aghoutan, Asmaa El Mabrak, Mohamed Mahtar and Mohamed El Fatmi Kadri Hassani",slug:"orthodontic-management-of-adult-sleep-apnea-clinical-case-reports",totalDownloads:86,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"78791",title:"Surface Modification of Titanium Orthodontic Implants",doi:"10.5772/intechopen.100038",signatures:"Abdulqadir Rampurawala and Amol Patil",slug:"surface-modification-of-titanium-orthodontic-implants",totalDownloads:146,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"79334",title:"Orthodontic Therapeutic Biomarkers in Saliva and Gingival Crevicular Fluid",doi:"10.5772/intechopen.100733",signatures:"Sagar S. Bhat, Ameet V. Revankar and Shrinivas M. Basavaraddi",slug:"orthodontic-therapeutic-biomarkers-in-saliva-and-gingival-crevicular-fluid",totalDownloads:127,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"78213",title:"A Review of Current Concepts in Full Arch Rehabilitation with Dental Implants",doi:"10.5772/intechopen.99704",signatures:"Leandro Díez-Suárez",slug:"a-review-of-current-concepts-in-full-arch-rehabilitation-with-dental-implants",totalDownloads:137,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Leandro",surname:"Díez Suárez"}],book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}}]},publishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"7999",title:"Free Radical Medicine and Biology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7999.jpg",slug:"free-radical-medicine-and-biology",publishedDate:"July 15th 2020",editedByType:"Edited by",bookSignature:"Kusal Das, Swastika Das, Mallanagouda Shivanagouda Biradar, Varaprasad Bobbarala and S. Subba Tata",hash:"083e5d427097d368a3f8a02bd6c76bf8",volumeInSeries:10,fullTitle:"Free Radical Medicine and Biology",editors:[{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8762",title:"Melatonin",subtitle:"The Hormone of Darkness and its Therapeutic Potential and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/8762.jpg",slug:"melatonin-the-hormone-of-darkness-and-its-therapeutic-potential-and-perspectives",publishedDate:"June 24th 2020",editedByType:"Edited by",bookSignature:"Marilena Vlachou",hash:"bfbc5538173f11acb0f9549a85b70489",volumeInSeries:9,fullTitle:"Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives",editors:[{id:"246279",title:"Associate Prof.",name:"Marilena",middleName:null,surname:"Vlachou",slug:"marilena-vlachou",fullName:"Marilena Vlachou",profilePictureURL:"https://mts.intechopen.com/storage/users/246279/images/system/246279.jpg",institutionString:"National and Kapodistrian University of Athens",institution:{name:"National and Kapodistrian University of Athens",institutionURL:null,country:{name:"Greece"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8002",title:"Tumor Progression and Metastasis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8002.jpg",slug:"tumor-progression-and-metastasis",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Ahmed Lasfar and Karine Cohen-Solal",hash:"db17b0fe0a9b6e80ff02b81a93bafa4e",volumeInSeries:8,fullTitle:"Tumor Progression and Metastasis",editors:[{id:"32546",title:"Dr.",name:"Ahmed",middleName:null,surname:"Lasfar",slug:"ahmed-lasfar",fullName:"Ahmed Lasfar",profilePictureURL:"https://mts.intechopen.com/storage/users/32546/images/system/32546.png",institutionString:"Rutgers, The State University of New Jersey",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6897",title:"Biophysical Chemistry",subtitle:"Advance Applications",coverURL:"https://cdn.intechopen.com/books/images_new/6897.jpg",slug:"biophysical-chemistry-advance-applications",publishedDate:"February 19th 2020",editedByType:"Edited by",bookSignature:"Mohammed A. A. Khalid",hash:"0ad18ab382e2ffb9ff202d15282297eb",volumeInSeries:7,fullTitle:"Biophysical Chemistry - Advance Applications",editors:[{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",institutionString:"Taif University",institution:{name:"Taif University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:16,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:4,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"40",title:"Ecosystems and Biodiversity",scope:"\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices"},{id:"38",title:"Pollution",scope:"\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment"},{id:"41",title:"Water Science",scope:"