Thiamin is an essential water-soluble nutrient that is naturally available in some foods and available as a supplement. This nutrient plays a vital role in metabolism, cell growth and development. The recommended daily intake of thiamin for adults is around 1.1–1.2 mg/day. Several studies have described that thiamin deficiency is commonly seen in critically ill patients, mainly sepsis. Thiamin deficiency reduces pyruvate access to the Krebs cycle, therefore, increases the production of lactate. The administration of thiamin in critically ill patients has been linked to better outcomes and depletion of mortality rate.
Part of the book: B-Complex Vitamins