Prevalence of parental physical violence (assessed with the Parent-Child Conflict Tactics Scale) in a sample of 7-year-old children from Generation XXI, a birth cohort from Porto, Portugal (N = 4175).
\\n\\n
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6749",leadTitle:null,fullTitle:"Simulation and Modelling of Electrical Insulation Weaknesses in Electrical Equipment",title:"Simulation and Modelling of Electrical Insulation Weaknesses in Electrical Equipment",subtitle:null,reviewType:"peer-reviewed",abstract:"Around 80% of electrical consumption in an industrialised society is used by machinery and electrical drives. Therefore, it is key to have reliable grids that feed these electrical assets. Consequently, it is necessary to carry out pre-commissioning tests of their insulation systems and, in some cases, to implement an online condition monitoring and trending analysis of key variables, such as partial discharges and temperature, among others. Because the tests carried out for analysing the dielectric behaviour of insulation systems are commonly standardised, it is of interest to have tools that simulate the real behaviour of those and their weaknesses to prevent electrical breakdowns. The aim of this book is to provide the reader with models for electrical insulation systems diagnosis.",isbn:"978-1-78923-769-6",printIsbn:"978-1-78923-768-9",pdfIsbn:"978-1-83881-685-8",doi:"10.5772/intechopen.72459",price:119,priceEur:129,priceUsd:155,slug:"simulation-and-modelling-of-electrical-insulation-weaknesses-in-electrical-equipment",numberOfPages:214,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"f10484c09f13914d4eaf8196b89b10e4",bookSignature:"Ricardo Albarracín Sánchez",publishedDate:"October 17th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6749.jpg",numberOfDownloads:10363,numberOfWosCitations:34,numberOfCrossrefCitations:38,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:44,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:116,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 20th 2017",dateEndSecondStepPublish:"December 11th 2017",dateEndThirdStepPublish:"February 9th 2018",dateEndFourthStepPublish:"April 30th 2018",dateEndFifthStepPublish:"June 29th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"192893",title:"Dr.",name:"Ricardo",middleName:null,surname:"Albarracín Sánchez",slug:"ricardo-albarracin-sanchez",fullName:"Ricardo Albarracín Sánchez",profilePictureURL:"https://mts.intechopen.com/storage/users/192893/images/6398_n.jpg",biography:"Ricardo Albarracín received his M.Sc. and Ph.D. (Partial discharge measurements in the UHF range) degrees in Electrical Engineering in 2010 and 2014, respectively, from Universidad Carlos III de Madrid. Currently, he is Assistant Professor of Electrical machines, Control of electrical machines and drives, and Numerical calculations in engineering modules at the Senior Technical School of Engineering and Industrial Design (ETSIDI), Universidad Politécnica de Madrid (UPM), Spain. Besides, he is member of the research group Networks and installations of low-voltage and high-voltage (RIBAT) and Assistant to the Director for International Mobility at ETSIDI. His main research interest areas are electrical insulation diagnosis, partial discharges, condition monitoring, power transformers, UHF sensors, and the integration of renewable sources in power systems.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"735",title:"Circuit Design",slug:"circuit-design"}],chapters:[{id:"61589",title:"Assessment of Dielectric Paper Degradation through Mechanical Characterisation",doi:"10.5772/intechopen.77972",slug:"assessment-of-dielectric-paper-degradation-through-mechanical-characterisation",totalDownloads:1239,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Power transformers life is limited fundamentally by the insulation paper state, which can be analysed through different techniques such as furanic compound concentration, dissolved gases, methanol concentration, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscope, refractive index of cellulose fibres, degree of polymerisation or tensile strength. The two last techniques provide the best way to evaluate mechanical resistance of insulation paper. This chapter describes briefly the most remarkable studies about post-mortem assessment and thermal ageing tests in which mechanical properties are some of the characteristics evaluated to determine paper degradation. This work also gathers the main relationships developed until now to relate different by-products generated during transformer operation with loss of paper mechanical properties. Finally, this chapter defines the future approaches, which could be used to study paper degradation.",signatures:"Cristina Fernández-Diego, Inmaculada Fernández, Felix Ortiz, Isidro\nCarrascal, Carlos Renedo and Fernando Delgado",downloadPdfUrl:"/chapter/pdf-download/61589",previewPdfUrl:"/chapter/pdf-preview/61589",authors:[{id:"239244",title:"Ph.D. Student",name:"Cristina",surname:"Fernández-Diego",slug:"cristina-fernandez-diego",fullName:"Cristina Fernández-Diego"},{id:"239248",title:"Dr.",name:"Inmaculada",surname:"Fernández",slug:"inmaculada-fernandez",fullName:"Inmaculada Fernández"},{id:"251903",title:"Dr.",name:"Felix",surname:"Ortiz",slug:"felix-ortiz",fullName:"Felix Ortiz"},{id:"251904",title:"Dr.",name:"Isidro Alfonso",surname:"Carrascal",slug:"isidro-alfonso-carrascal",fullName:"Isidro Alfonso Carrascal"},{id:"251905",title:"Dr.",name:"Carlos Javier",surname:"Renedo",slug:"carlos-javier-renedo",fullName:"Carlos Javier Renedo"},{id:"251906",title:"Dr.",name:"Fernando",surname:"Delgado",slug:"fernando-delgado",fullName:"Fernando Delgado"}],corrections:null},{id:"61792",title:"Thermal Modelling of Electrical Insulation System in Power Transformers",doi:"10.5772/intechopen.78070",slug:"thermal-modelling-of-electrical-insulation-system-in-power-transformers",totalDownloads:1320,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Temperature is one of the limiting factors in the application of power transformers. According to IEC 60076-7 standard, a temperature increase of 6°C doubles the insulation ageing rate, reducing the expected lifetime of the device. Power losses of the transformer behave as a heating source, and the insulating liquids act as a coolant circulating through the windings and dissipating heat. For these reasons, thermal modelling becomes an important fact of transformer design, and both manufacturers and utilities consider it. Different techniques for thermal modelling have been developed and used for determining the hot-spot temperature, which is the highest temperature in the winding, and it is related with the degradation rate of the solid insulation. First models were developed as a first estimation for modelling the hot-spot temperature and the top-oil temperature. These models were based on thermal-electric analogy and are known as dynamic models. Other two different kinds of models are widely used for thermal modelling, known as Computational Fluid Dynamics (CFD) and Thermal Hydraulic Network Models (THNMs). These two techniques determine the temperature and velocity fields in the winding and in the insulating fluid. In this chapter, the different techniques for transformer thermal modelling will be introduced and described.",signatures:"Agustín Santisteban, Fernando Delgado, Alfredo Ortiz, Carlos J.\nRenedo and Felix Ortiz",downloadPdfUrl:"/chapter/pdf-download/61792",previewPdfUrl:"/chapter/pdf-preview/61792",authors:[{id:"24550",title:"Dr.",name:"Carlos",surname:"Renedo",slug:"carlos-renedo",fullName:"Carlos Renedo"},{id:"26667",title:"Dr.",name:"Alfredo",surname:"Ortiz",slug:"alfredo-ortiz",fullName:"Alfredo Ortiz"},{id:"239344",title:"Ph.D. Student",name:"Agustín",surname:"Santisteban",slug:"agustin-santisteban",fullName:"Agustín Santisteban"},{id:"245139",title:"Dr.",name:"Fernando",surname:"Delgado",slug:"fernando-delgado",fullName:"Fernando Delgado"},{id:"245141",title:"Dr.",name:"Félix",surname:"Ortiz",slug:"felix-ortiz",fullName:"Félix Ortiz"}],corrections:null},{id:"61773",title:"Modeling and Simulation of Rotating Machine Windings Fed by High-Power Frequency Converters for Insulation Design",doi:"10.5772/intechopen.78064",slug:"modeling-and-simulation-of-rotating-machine-windings-fed-by-high-power-frequency-converters-for-insu",totalDownloads:1597,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Modern power systems include a considerable amount of power electronic converters related to the introduction of renewable energy sources, high-voltage direct current (HVDC) systems, adjustable speed drives, and so on. These components introduce repetitive pulses generated by the commutation of semiconductor switches, resulting in overvoltages with very steep fronts and high dielectric stresses. This phenomenon is one of the main causes of accelerated insulation aging of motors in power electronic-based systems. This chapter presents state-of-the-art computational tools for the analysis of motor windings excited by fast-front pulses related to the use of frequency converters based on pulse-width modulation (PWM). These tools can be applied for the accurate prediction of overvoltages and dielectric stresses required to propose insulation design improvements. In the case of the stress-grading system used in medium-voltage (MV) motors, transient finite-element method (FEM) is used to study the effect of fast pulses. It is shown how, by controlling the material properties and the design of the stress-grading systems, solutions to reduce the adverse effects of fast pulses from PWM-type inverters can be proposed.",signatures:"Fermin P. Espino Cortes, Pablo Gomez and Mohammed Khalil\nHussain",downloadPdfUrl:"/chapter/pdf-download/61773",previewPdfUrl:"/chapter/pdf-preview/61773",authors:[{id:"238065",title:"Associate Prof.",name:"Pablo",surname:"Gomez",slug:"pablo-gomez",fullName:"Pablo Gomez"},{id:"238796",title:"Dr.",name:"Fermin P.",surname:"Espino-Cortés",slug:"fermin-p.-espino-cortes",fullName:"Fermin P. Espino-Cortés"},{id:"245189",title:"Dr.",name:"Mohammed Khalil",surname:"Hussain",slug:"mohammed-khalil-hussain",fullName:"Mohammed Khalil Hussain"}],corrections:null},{id:"61541",title:"Development Prospect of Gas Insulation Based on Environmental Protection",doi:"10.5772/intechopen.77035",slug:"development-prospect-of-gas-insulation-based-on-environmental-protection",totalDownloads:1198,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The research situation of environmentally friendly gas insulation is expounded in this paper. The basic physical and chemical properties of the insulating gases are analysed, to propose several environment-friendly insulating gas of potential alternative to sulphur hexafluoride (SF6). The insulation characteristics of different components gas mixtures with 90% of nitrogen (N2) and carbon dioxide (CO2) as buffer gas and 10% octafluorocyclobutane (c-C4F8), Trifluoroiodomethane (CF3I) and heptafluorobutyronitrile (C4F7N) as the main insulating gas had been tested with 5–20 mm sphere-plane electrode gaps in non-uniform electric field under the power frequency voltage and positive and negative lightning impulse breakdown. The development prospects of environmentally friendly gas insulation are forecasted. Further analysis of c-C4F8,CF3I and C4F7N (some friendly gases, which have the potential to replace SF6) are conducted trying to points out the further research direction.",signatures:"Dengming Xiao",downloadPdfUrl:"/chapter/pdf-download/61541",previewPdfUrl:"/chapter/pdf-preview/61541",authors:[{id:"18115",title:"Dr.",name:"Dengming",surname:"Xiao",slug:"dengming-xiao",fullName:"Dengming Xiao"}],corrections:null},{id:"63042",title:"Typical Internal Defects of Gas-Insulated Switchgear and Partial Discharge Characteristics",doi:"10.5772/intechopen.79090",slug:"typical-internal-defects-of-gas-insulated-switchgear-and-partial-discharge-characteristics",totalDownloads:1699,totalCrossrefCites:10,totalDimensionsCites:10,hasAltmetrics:0,abstract:"Gas-insulated switchgear (GIS) is a common electrical equipment, which uses sulfur hexafluoride (SF6) as insulating medium instead of traditional air. It has good reliability and flexibility. However, GIS may have internal defects and partial discharge (PD) is then induced. PD will cause great harm to GIS and power system. Therefore, it is of great importance to study the intrinsic characteristics and detection of PD for online monitoring. In this chapter, typical internal defects of GIS and the PD characteristics are discussed. Several detection methods are also presented in this chapter including electromagnetic method, chemical method, and optical method.",signatures:"Fuping Zeng, Ju Tang, Xiaoxing Zhang, Siyuan Zhou and Cheng Pan",downloadPdfUrl:"/chapter/pdf-download/63042",previewPdfUrl:"/chapter/pdf-preview/63042",authors:[{id:"197319",title:"Prof.",name:"Xiaoxing",surname:"Zhang",slug:"xiaoxing-zhang",fullName:"Xiaoxing Zhang"},{id:"205017",title:"Prof.",name:"Ju",surname:"Tang",slug:"ju-tang",fullName:"Ju Tang"},{id:"210705",title:"Dr.",name:"Fuping",surname:"Zeng",slug:"fuping-zeng",fullName:"Fuping Zeng"},{id:"210707",title:"Dr.",name:"Cheng",surname:"Pan",slug:"cheng-pan",fullName:"Cheng Pan"},{id:"279579",title:"Dr.",name:"Siyuan",surname:"Zhou",slug:"siyuan-zhou",fullName:"Siyuan Zhou"}],corrections:null},{id:"62153",title:"Electrical Insulation Weaknesses in Wide Bandgap Devices",doi:"10.5772/intechopen.77657",slug:"electrical-insulation-weaknesses-in-wide-bandgap-devices",totalDownloads:1254,totalCrossrefCites:23,totalDimensionsCites:26,hasAltmetrics:0,abstract:"The power electronics research community is balancing on the edge of a game-changing technological innovation: as traditionally silicon (Si) based power semiconductors approach their material limitations, next-generation wide bandgap (WBG) power semiconductors are poised to overtake them. Promising WBG materials are silicon carbide (SiC), gallium nitride (GaN), diamond (C), gallium oxide (Ga2O3) and aluminum nitride (AlN). They can operate at higher voltages, temperatures, and switching frequencies with greater efficiencies compared to existing Si, in power electronics. These characteristics can reduce energy consumption, which is critical for national economic, health, and security interests. However, increased voltage blocking capability and trend toward more compact packaging technology for high-power density WBG devices can enhance the local electric field that may become large enough to raise partial discharges (PDs) within the module. High activity of PDs damages the insulating silicone gel, lead to electrical insulation failure and reduce the reliability of the module. Among WBG devices, electrical insulation weaknesses in WBG-based Insulated Gate Bipolar Transistor (IGBT) have been more investigated. The chapter deals with (a) current standards for evaluation of the insulation systems of power electronics modules, (b) simulation and modeling of the electric field stress inside modules, (c) diagnostic tests on modules, and (d) PD control methods in modules.",signatures:"Mona Ghassemi",downloadPdfUrl:"/chapter/pdf-download/62153",previewPdfUrl:"/chapter/pdf-preview/62153",authors:[{id:"235732",title:"Dr.",name:"Mona",surname:"Ghassemi",slug:"mona-ghassemi",fullName:"Mona Ghassemi"}],corrections:null},{id:"61498",title:"Simulation and Optimization of Electrical Insulation in Power Quality Monitoring Sensors Applied in the Medium-Voltage",doi:"10.5772/intechopen.77187",slug:"simulation-and-optimization-of-electrical-insulation-in-power-quality-monitoring-sensors-applied-in-",totalDownloads:957,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Thanks to the Smart Grid initiative, the focus for medium-voltage MV (13.8–34 kV) smart meters leveraged the development of sensors for distribution application. In order to be useful at power quality monitoring, the sensors needs to attend, at least, the International Electrotechnical Commission (IEC) 61000–4-30 and IEC 61000–4-7 standards with high-accuracy in terms of voltage (less than 0.1%), current (less than 1.0%) and measuring the waveform distortion data up to the 50th harmonic of 50 or 60 Hz alternating frequency. This kind of sensor is built with two capacitors connected in series. The first capacitor is a commercial electronic low-voltage device. One terminal of this capacitor is connected to the medium-voltage (MV) conductor. The second one, is connected to the other capacitor that is constructed using the own sensor packaging. This second capacitor has an electrode, that is connected with the first capacitor and the other terminal is connected to the ground. The voltage is measured between the terminals of the low voltage capacitor. The performance of this capacitor depends on the geometry and the materials used in the electrical insulation. This chapter describes the simulations and modeling of the capacitor electrodes using a finite-elements software, COMSOL Multiphysics, for modeling in order to optimize the performance of sensor in terms of electric field distribution.",signatures:"Sender Rocha dos Santos, Rodrigo Peres, Wagner Francisco\nRezende Cano and Joao Batista Rosolem",downloadPdfUrl:"/chapter/pdf-download/61498",previewPdfUrl:"/chapter/pdf-preview/61498",authors:[{id:"202012",title:"Dr.",name:"Joao",surname:"Batista Rosolem",slug:"joao-batista-rosolem",fullName:"Joao Batista Rosolem"},{id:"235941",title:"MSc.",name:"Sender",surname:"Rocha dos Santos",slug:"sender-rocha-dos-santos",fullName:"Sender Rocha dos Santos"},{id:"238954",title:"Mr.",name:"Rodrigo",surname:"Peres",slug:"rodrigo-peres",fullName:"Rodrigo Peres"},{id:"239584",title:"M.Sc.",name:"Wagner",surname:"Francisco Rezende Cano",slug:"wagner-francisco-rezende-cano",fullName:"Wagner Francisco Rezende Cano"}],corrections:null},{id:"63502",title:"Generator Insulation-Aging On-Line Monitoring Technique Based on Fiber Optic Detecting Technology",doi:"10.5772/intechopen.78065",slug:"generator-insulation-aging-on-line-monitoring-technique-based-on-fiber-optic-detecting-technology",totalDownloads:1100,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The relationship between insulation aging and generator lifespan using fiber optic sensors (FOSs) is explored to ultimately improve asset lifespan through smart choices in running conditions and maintenance. Insulation aging is a major factor that causes generator failure. FOS provides the rare opportunity of being installed up close to the insulation, monitoring degradations that are otherwise difficult to detect. FOSs, unlike purely electrical transducers, are immune to high voltage (HV) and strong electromagnetic (EM) fields. They are small and have a proven long life by their deployment in the Telecom industry. The proposed FOS is a Fabry-Perot cavity made up of two identical fiber Bragg gratings (FBGs) using light wave interference as the working principle. Such architecture delivers simultaneous vibration (10 Hz–1 kHz) and temperature (0.1°C resolution) monitoring, both helping to spot irregular vibration patterns (signatures) and hot-spots inside the generator stator slots. The signal processing unit equipped with a gateway device can help to connect the large volume of sensor data, allowing correlation with the supervisory control and data acquisition (SCADA) system data of the plant. This chapter also elaborates on the field test jointly conducted with Calpine Corporation and Oz Optics, Ltd. 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(2) the magnitude of the problem affecting particularly the most vulnerable groups; (3) the potential for intergenerational transmission; and (4) a smashing impact at different levels of influence, namely individuals, families, neighborhoods, communities, and society [1, 2, 3, 4].
Violence can take several forms throughout the life cycle, being an individual’s age is an important determinant of the type of violence that people may experience [5]. Therefore, violence has causes, intents, circumstances, and contributing factors that vary according to each individual life cycle stage. Linking together all these events, experiences and behaviors makes it possible to map out developmental pathways from childhood to later ages [5, 6]. With longitudinal studies, it is possible to study continuity and changes occurring in life as they are central to identifying links between distinct phenomena over the life course and thus to describe social processes that both produce and alter developmental trajectories. Such links are essential to understanding the continuity of the experience and behavior, as well as life-course changes that create new states and circumstances that might be unexpected.
Importantly, this concern with the development process includes a wide range of life outcomes [7]. One of the more prominent themes in life-course research is the identification of factors that put one at risk for adversity in later life.
Additionally, violence is a sensitive topic to research, with specific challenges that are different from those that arise when studying other social or health problems. Usually, monitoring systems restrict the occurrence of interpersonal violence to those who seek hospital care or report their experiences to authorities or social support systems [8]. Therefore, researchers who aim to identify and measure violence besides the tip of the iceberg will need to ask people about violent experiences that occur behind closed doors. Even more challenging is when the goal is to study violence in children, where more delicate ethical issues arise, such as obtaining consent for participation in the research that needed to be provided by their own parents; conducting interviews with or administering tests to the children; and providing information about test results to parents or others outside the research team. The research team faces questions as who is responsible for giving consent for children to participate in research, which is further complicated by the potential adversarial relationship between abusing parent and abused child [9].
Among the methodological challenges that should be addressed are the need to explore the effects of multiple forms of maltreatment and the timing, chronicity, and discontinuity of violence episodes. Some children may live in a continually abusive environment, while others may experience only one incident of brief duration [10]. Thus, longitudinal research allows distinguishing between repetitive violence episodes over time and isolated incidents of violence. Moreover, false reporting may not be discarded when we are assessing violence or abuse experiences. However, evidence shows that false allegations of abuse are much less common than the problem of victims who fail to report abuse, and the widespread false denials and minimization of violence by perpetrators, and in general, abuse is vastly under-reported [11]. Also, many of these experiences, especially those suffered by children and women, may remain hidden since perpetrators have an interest in hampering reports and detection.
This chapter aims to demonstrate the importance of a life-course perspective to understand the detrimental relationship between early exposure to violence and worse health in the first years of life.
Violence against children includes all forms of violence whether perpetrated by parents or other caregivers, peers, partners, or strangers. This problem is identified as a public health issue and a human rights concern with high social impact, and potentially devastating and costly consequences [12]. Levels of violence against children are extremely high, and it is estimated that, worldwide, up to 1 billion children aged 2–17 years experienced neglect or were victims of physical, sexual, or emotional violence in their lifetime [13].
Childhood is the most important period of development during life course, highly sensitive to external influences and with a profound impact on children’s lives [14, 15]. During this period, the foundations for every individual’s physical and mental health capacities and attainment are laid, influencing growth, development, and well-being in adolescence and adulthood.
Early life experiences and environments may negatively influence later experiences, opportunities, and health risk factors [16]. Thus, being exposed to violence during childhood and adolescence could be particularly disruptive to normal psychological development when it occurs during these periods [17] and may damage health over time.
The exposure to violent experiences should be approached since the perinatal period.
Violence against women may have direct and indirect effects on the children. Intimate partner violence can have significant adverse effects on victims at any time in their life but has special significance during pregnancy because of the added potential harms to the unborn child. The detrimental effects of adverse and negative gestational experiences, including exposure to violence during pregnancy, on many aspects of a child’s development, are well described in the literature [18]. Intimate partner violence during pregnancy is associated with poor health outcomes for the fetus, newborn, and infant up to 1 year postpartum [19, 20]. A study conducted in a public maternity of a general Portuguese university hospital showed that one in 10 women reported physical abuse during pregnancy, and almost half of them reported they had suffered severe acts, such as punching, kicking, bruises, cuts, and/or continuing pain, beaten up, severe contusions, broken bones, head, internal, and/or permanent injury [21]. Also, this study showed that reports of physical abuse during pregnancy were significantly associated with preterm delivery (odds ratio (OR) =3.72; 95% confidence interval (95%CI) between 2.59 and 5.33) [21]. Exposure to violence during pregnancy also increases the risk for antepartum hemorrhage, a condition that can be fatal for the unborn [22, 23], increased fetal morbidity [24], intrauterine growth restriction [23], and low birth weight [19].
Being that the womb is a shared environment between mother and infant, maternal experiences can also affect the developing fetus. On one hand, experiences of abuse, occurring either before and during pregnancy, increase the likelihood of abused women being involved in behaviors that may be detrimental to the fetus, including smoking [25], drug use [26, 27], being overweight [28], stress [29], when compared to unexposed women. On the other hand, increased risk of the health outcomes on the child may occur through different pathways: (1) dysregulation of the locus coeruleus-noradrenergic system through the effects of maternal cortisol on epigenetic modification of genes controlling the development of this system [30, 31]); (2) disruption of brain development by impairing placental circulation [32]); (3) dysregulation of the hypothalamic-pituitary-adrenal axis in the fetus [18, 33]; and (4) triggering of developmental immunotoxicity, through autoimmunity or inflammation of myelomonocytic cells in the brain [34]. Depending on the system affected, several outcomes may emerge on the child’s health. Prenatal stress may have a lasting impact on the child’s behavior, increasing the risk of autism spectrum disorder [35], Attention Deficit Hyperactivity Disorder (ADHD) [36], and worse general intellectual and language functioning [37]. For instance, increased maternal cortisol along with a downregulation of the enzyme 11β-HSD2, which converts cortisol into its inactive form, can lead to changes in behavioral development and make the infant more susceptible to stress later in life [38].
On the other hand, children living in a family where the mother is exposed to violence are frequently abused themselves, and mothers exposed to violence or threats are often insufficient caregivers which could affect the children regardless of whether they have seen the violent act or not [39].
In 1962, child maltreatment received widespread attention by the medical profession and the general public after Kempe’s publication [40]. Kempe described the battered child syndrome, characterized by the clinical manifestations of serious physical abuse in young children, generally inflicted by a parent or a foster parent. In this chapter, Kempe stated that “physicians, because of their feelings and their difficulty in playing a role that they find hard to assume, may have great reluctance in believing that parents were guilty of abuse” [40].
Violence against children perpetrated by adults within the family is one of the least visible forms of child maltreatment, as much of it takes place in the privacy of domestic life. However, this problem is widely prevalent in all societies [41]. Much physical violence against children is inflicted as a punishment, and it is accepted by parents once it is considered by the prevailing social norms as the correct means of discipline. Corporal punishment of children in the form of hitting, punching, kicking, or beating, is socially and legally accepted in some countries [12], being, therefore, a common form of parental discipline toward their children.
Several factors and conditions have been associated with parental violence, including parent characteristics (i.e., parents’ own experience of child maltreatment, age and educational level, cognitive ability, and personality), child characteristics (i.e., age and sex), and sociodemographic conditions (i.e., household income, number of children in the household) [42, 43, 44]. Low-income and economic hardship strain parents’ mental health, increase the likelihood of family conflict, and reduce interaction among family members in a responsive and nurturing manner, which predict poor child developmental outcomes [45, 46, 47].
Also, parental beliefs and cultural acceptance that corporal punishment is a way to raise and educate their children to contribute to these forms of discipline have not been yet abandoned. Even in wealthy and considered highly developed societies, such as Switzerland, it was estimated that 54.4% of children aged 1–14 suffered forms of corporal punishment at home [48]. In the United States, corporal punishment remains a legal and well-accepted form of disciplining children, with prevalence studies reporting 64–95% of parents use spanking between the ages of 2 and 3 [49]. Worldwide, one in four adults reports having been physically abused as a child by their parents or other caregivers [12], three-quarters of world children aged 2 to 4 are regularly victims of violent discipline by their parents or other caregivers [50], and around six in 10 children aged 2–14 are frequently punished physically [51]. However, a growing number of countries are passing laws prohibiting its use at home. A study conducted in the scope of a Portuguese population-based cohort (the Generation XXI) showed a high prevalence of physical violent discipline [52]. In this study, the parent-child Conflict Tactics Scale (CTSPC) was administered to 4175 children by trained interviewers to report parents’ disciplinary practices. This instrument includes 23 items that allow us to measure three different forms of lifetime parental disciplinary acts: (1) non-violent discipline, characterized by positive practices widely used as alternatives to corporal punishment; (2) psychological aggression, which includes verbal and symbolic acts to cause psychological pain or fear to the child; and (3) physical assault, which comprises the use of corporal punishment that may include acts of physical abuse. An interviewer shows the child a picture card and reads a description, such as “This girl’s father hits her with a belt when she does something wrong. When you do something wrong, does your father hit you with a belt?” If the response is yes, the interviewer shows a second card with the response categories in the form of stacked circles that the child could point to. Answers to the child-report form items were rated using a 5-point Likert-type scale, ranging from “Never” to “Always,” with higher scores indicating a higher occurrence of the parental disciplinary act. Child-reported discipline practices used by parents were recoded as “never” if the child did not report any act of parental violent discipline, as “sometimes” if the child reported that the tactic occurred “once” or “sometimes” and as “frequently” if the child reported its occurrence as “frequently” and “always.”
Table 1 shows the frequency of physical violence reported by the children. These results show us the high frequency of corporal punishment as a tactic of parental discipline. In Portugal, although a Law introduced in 2007 has amended the Portuguese Penal Code to prohibit all forms of corporal punishment of children, including by parents [53], physical discipline is still observed.
n (%) | ||
Corporal punishment | Never | 671 (16.1) |
Sometimes | 867 (20.8) | |
Frequently | 2637 (63.1) | |
Severe physical assault | Never | 3605 (86.3) |
Sometimes | 401 (9.6) | |
Frequently | 169 (4.1) | |
Very severe physical assault | Never | 4056 (97.1) |
Sometimes | 95 (2.3) | |
Frequently | 24 (0.6) |
Prevalence of parental physical violence (assessed with the Parent-Child Conflict Tactics Scale) in a sample of 7-year-old children from Generation XXI, a birth cohort from Porto, Portugal (N = 4175).
Also, the social environment in which a child is born and raised affects the nature and quality of social relations and interactions, which, in turn, impacts growth, development, and future achievements. In literature, it has been described that a warm and sensitive parenting style contributes to a child’s positive social behavior and supportive peer relationships [54]. In contrast, unstable, neglectful, or abusive families are associated with episodes of aggressiveness, and impulsivity in the children, impairing their development of tactics to solve a conflict with peers [55], and increasing the risk of violent, aggressive, and bullying behaviors in settings, such as school, that is, outside home environments [56].
Results from the children followed by the cohort Generation XXI showed an increased likelihood of involvement as a bully in children from families with a history of household criminality, that witness parental violence and victims of physical violence [57]. These findings suggest that exposure to household dysfunction might impact children’s emotional and behavioral development. Thus, being exposed to or witnessing other forms of victimization at home might increase their susceptibility to being involved in bullying [58], as children might see it as an acceptable way to manage interpersonal conflicts.
Children are entitled and must be provided with a safe, nurturing, and inclusive environment where they can grow, learn, thrive, and succeed, achieving their full potential as students and citizens [59]. Communities devote their confidence and expect that schools are the providers of such non-violent environments. However, students all over the world see their ability to fully benefit from educational opportunities endangered by the presence or threat of violence at school, exerted mainly by their peers.
Violence among school-age children and adolescents is a worldwide problem, with negative impact and consequences for the physical and psychological health of those involved, and also, increased risk of behavioral and social problems [12]. Violence at school has also other consequences, such as lower rates of attendance, contributes to lower academic results, and leads to higher drop-out rates [50].
The most traditional forms of peer violence occurring in the educational context comprise bullying, cyberbullying, and physical fighting.
Bullying is an intentional aggressive and negative behavior, repeated over time, that involves a power imbalance favoring the aggressor, with victims having no means to defend themselves [60]. The most common forms of bullying behaviors among adolescents are name-calling, teasing, making threats, spreading rumors, taking of personal belongings, and rejection by excluding someone from a group on purpose [61]. Most of the bullying situations tend to start in school, and sometimes they are not taken as seriously but, instead, as a normal interaction between peers [62]. Children or adolescents involved in bullying can dress the role of victims when the child suffers from bullying but is not an aggressor; as bullies, when the involvement is sole as the aggressor, but not as a victim; and as bully-victim when the child is involved as both victim and aggressor simultaneously.
Estimates of bullying prevalence vary greatly across surveys. A survey conducted by the Health Behavior in School-Aged Children (HBSC) study, in 42 countries and regions across the World Health Organization (WHO) European Region and North America, showed that between 3 and 35% of young people reported involvement in bullying during the past 2 months [63]. According to the WHO European Health Information Gateway from 2017, 11% of girls and 17% of boys aged 11 years old, and 14% of girls and 16% of boys aged 13 have reported being victims of bullying at least twice in the previous 2 months [64].
In a study conducted in the scope of a Portuguese population-based cohort (the Generation XXI) the bullying behavior was assessed through the Bully Scale Survey developed by the Centers for Disease Control and Prevention (CDC) [65]. This scale collects information on the experience of bullying as a victim (11 items) and as a bully (11 items). At the age of 10 years, for each item, the child was asked to indicate the frequency of bullying involvement, choosing between five options—“never,” “rarely,” “sometimes,” “often,” and “always.” As bullying is a repeated behavior, the child was categorized as a victim, when reporting the occurrence of at least one of the items as “often” or “always” in the victimization scale, but answered “never,” “rarely,” or “sometimes” in the aggression scale; the child was classified as a “bully” when answered “often” or “always” in the aggression scale, but answered “never,” “rarely,” or “sometimes” in the victimization scale; finally, the child was categorized as “bully-victim” when reported to be involved both as a victim and as an aggressor simultaneously.
Figure 1 shows results from 5338 participants of Generation XXI. Overall, near 20% of children aged 10 years reported to have been involved in bullying; involvement as only the victim was reported by 14.4% of participants, involvement as only-bully by 1.4%, and involvement as both bully and victim by 3.9%. Boys were more frequently involved in bullying than girls (16.6% versus 12.0% as victims; 2.0% versus 0.7% as bullies; and 5.5% versus 2.3% as bully-victims) [57].
Prevalence of bullying by sex according to the type of involvement assessed (victimization, aggression, and victimization and aggression simultaneously) among 10-year-old children.
In our society, gender constitutes a structure of social practice that establishes relations of power, attitudes, and hierarchies among people, groups, and institutions [66], and this is reflected in the interaction between children, and consequently in bullying behaviors. Research suggests that boys are more prone to be victims and aggressors of bullying, especially in its physical expression [63, 67], while girls are more likely to engage in situations of indirect bullying, such as teasing or gossiping [62, 67, 68].
With the democratization of the use of new technologies and social media, a new form of peer violence has emerged, cyberbullying, that uses that platform as the scenario for the perpetration of aggressive behaviors [69]. Cyberbullying is the act of sending, posting, or sharing negative, harmful, false, or mean content about someone else through SMS, MMS, and apps, or online in social media, forums, or gaming where people can view, participate in, or share content. It aims to share personal or private information about someone else to cause embarrassment or humiliation. Some cyberbullying crosses the line into unlawful or criminal behavior [70].
However, as for bullying, the prevalence of cyberbullying estimates varies greatly across surveys. A previous scoping review described the prevalence of lifetime cybervictimization as ranging between 4.9 and 65.0%, prevalence of aggression ranging between 1.2 and 44.1%, and prevalence of being involved as victim and aggressor simultaneously ranging from 5.0 to 64.3% [71]. It is known that the attacks cause greater insecurity in the victim, as there are no places or moments to hide since aggressors can reach them almost everywhere [72]. In addition, due to how the violence is carried out, it can be observed by numerous bystanders for an indefinite number of times, which makes the potential damage even greater than that of traditional harassment [72]. Due to the potential of widespread accessibility of victims and an infinite audience by using communication technologies [73], cyberbullying is another important source of stress. Thus, we should also be monitoring the use of technologies as a common form of violence at these ages.
Physical fighting has been measured as a form of violence strongly related to violence in a community. This form of violence is of easy assessment and considered one of the main causes of child morbidity and mortality, accounting for one of the leading causes of death among adolescents aged 15 or over in Europe and America [74]. Physical fighting is defined as the use of an intentional force against others, with potentially serious consequences and injuries or death [75].
Particularly, there is a significant association between physical fighting involvement and other violent behaviors, such as carrying weapons and greater involvement in risk behaviors, being often associated with substance misuse, such as alcohol and drug use [75, 76, 77, 78], as well as media violence exposure [79, 80]. Studies examining the association between both the quantity and quality of sleep and aggression behavior among male adolescents showed that hostility was associated with both reduced quantity [81] and quality of sleep [82].
Violence can have different impacts and effects on the health of children and adolescents. Literature shows that exposure to stressful and traumatic experiences during sensitive periods of neurological and cognitive development in childhood may have lasting implications for physical, emotional, and mental health [12, 83] being a significant early determinant of disease onset and all-cause premature mortality [84, 85, 86].
The physical impacts of violence episodes are the most easily observable and recognizable and may include mild or serious wounds, bruises, fractures. However, we cannot discard that some violence experiences are not so visible but have a significant impact on children’s future health and well-being.
Regarding parental violence, parental and cultural beliefs that corporal punishment is an acceptable way to discipline and educate children, contribute to these forms of discipline not being yet abandoned. However, corporal punishment is responsible for thousands of deaths during childhood each year and regarding its survivors, it has been associated with health problems in childhood and later in life [87]. Given the stigmatizing nature of violence, and its occurrence in a place where the child is supposed to be safe, mostly perpetrated by the ones that should be the main protectors of the child by providing them with a healthy and safe environment, over-reporting is not common, and it is expected that prevalence estimates tend to underestimate the true magnitude of interpersonal violence.
Literature has shown that any experience of violence causes psychological distress and long-term mental ill-health [88]. Exposure to household conflicts poses a significant threat to children’s ability to process and regulate emotions, and it may result in uncontrolled or overcontrolled emotional reactions, contributing to both internalizing and externalizing behaviors [89]. Also, victims of corporal punishment both at home and at school are more likely to become passive and excessively cautious and to a fear-free expression of their ideas and feelings. Children who suffer physical punishment are less likely than other children to internalize moral values, to be altruistic, empathic, or to exercise moral judgment of any kind. Also, being a victim of both physical and psychological abuse increases the risk of depression, posttraumatic stress disorder (PTSD), and anxiety [90, 91].
The involvement in physical fights and bullying victimization is related to somatic symptoms and disturbances, reflecting the emotional effects of aggression. Adolescents involved in physical fights are more likely to present negative health outcomes, such as sleep problems, appetite suppression, and headaches [92, 93]. Similarly, in victims of bullying the most common stress-related symptoms include sleep disorders [94], gastrointestinal complaints, headaches, chronic pain [62, 95], and also bedwetting and tummy ache [96].
Additionally, a girl victim of bullying is at higher risk of suicidal ideation, feeling more nervous or stressed and angry than a boy [97]. One possible explanation is the fact that girls seem to externalize their emotions better and disclose their depressive feelings more easily than boys [62, 98, 99]. Results from a study conducted with adolescents showed that those involved in bullying were more likely to present negative well-being-related feelings, including feeling “nervous or stressed,” “angry,” “sad and desperate,” and also “suicidal ideation.” Suicidal ideation was strongly associated with being involved in bullying as bully-victim, in girls (OR = 8.34; 95% CI: 5.03; 3.82) and in boys (OR = 8.05; 95% CI: 4.24; 15.28) [67].
The link between violence and health may be explained by the biology of social adversity. Therefore, the exposure to violence during childhood may result in early life stress that has the potential to alter physiological systems, thus accounting for a more immediate effect of these exposures, including all the effects that occurred during childhood and adolescence, before adulthood, but that may not necessarily lead to disease. Although the mechanisms explaining the involvement in the biological embodiment of violence are poorly understood in early ages, accumulating evidence suggests that adversity may become programmed molecularly, leaving behind biological memories that can persistently translate into an increased susceptibility to disease later in life [100, 101, 102].
Inflammation, for instance, may be one of the potential mechanisms explaining the link between trauma and health outcomes. Longitudinal studies showed that elevated markers of inflammation, namely C-reactive protein (CRP) levels were observed in adults who experienced childhood adversity, such as parental separation [103], child maltreatment [104], and low socioeconomic status [105]. CRP is an acute-phase protein of hepatic origin whose circulating concentrations rise in response to inflammation. In hospital settings, it can be used to determine the risk of developing coronary artery disease. Although the health effects of violence are well documented in adults, more and more literature has been showing that these alterations start at very early ages. A systematic review aimed to summarize evidence reporting epigenetic and/or neuro-immuno-endocrine embedding of adverse childhood experiences, including violence and episodes of bullying, in children, with a particular focus on the short-term biological effect of those events [106]. The authors observed that the associations reported across studies followed the hypothesis that exposure to adversity is associated with increased biological alterations already at early ages, which may increase the risk of later health outcomes [106].
Empirical data from a birth cohort from Portugal, Generation XXI, showed that at the age of 7 years, children who reported more severe violence perpetrated by their parents presented significantly higher levels of hs-CRP [52]. Higher hs-CRP levels were observed among children reporting extreme violence, including “grab the children by the neck and choke them” or “burn the children or scald them on purpose” [52].
This is supporting evidence that adversity appears to get “under the skin” and induce physiological changes. Although little is known if these alterations in biological markers after experiencing abuse at early ages may be reversed, these results seem to support evidence for biological imprinting and short-term physiological effect of violence that might be strongly associated with later development of disease.
Due to some specificities regarding the type of involvement, bullying might have a different biological impact or health consequences depending on the involvement as a victim, aggressor, or both simultaneously. While evidence has shown that being bullied predicted higher increases in CRP levels, bullying others predicted lower increases in CRP compared with those uninvolved in bullying [107]. A systematic review [106] described other health consequences that were observed, such as higher DNA methylation, shorter telomere length [108], and lower cortisol levels among victims of bullying [109]. However, further investigation is needed to explore the impact of children’s type of involvement in bullying on different biological markers.
In conclusion, literature shows that violence and toxic stress induce physiological changes already in childhood and put children at increased risk for developing several diseases in adulthood, negatively impacting their quality of life and setting them in a less advantageous position [110, 111] from the early life onwards. Exposure to psychosocial stressors leads to continuous dysregulation of physiological responses resulting in the wear and tear on the body, an allostatic load with detrimental long-term health consequences [112].
Despite growing up and living in contexts of violence, not all children will develop the illness. Some of them even present indicators of healthy development, demonstrating to be resilient to such a disadvantaged environment [113]. The impact of social disadvantage in childhood and allostatic load in later life can be modified by individuals’ psychosocial resilience [112].
Resilience is the individuals’ capacity for overcoming the negative effects of risk exposure, coping successfully with adverse experiences as well as avoiding the negative trajectories associated with risk. This process is influenced by biological, psychological, social, and contextual factors [114]. The most consistent protective factors associated with resilience in children exposed to violence recognized by the literature are supportive parent-child relationships at a family level and self-regulation at an individual level [113].
Examining what differentiates children who demonstrate resilience from those who develop illness and assessing their ability to cope with unfavorable events is essential for informing interventions aiming to improve coping skills and competences promoting healthy trajectories [110, 115, 116]. The identification of the multidimensional processes underlying successful adaptation under adverse conditions allows the design and implementation of successful interventions for the most vulnerable children.
Resiliency Theory focuses on strengths rather than deficits, giving attention to assets (i.e., individual protective factors, such as social skills, coping skills, healthy beliefs, and self-efficacy) and resources (i.e., social and environmental context strengthening individuals facing the risk) which help children to be healthy adults and to have a good quality of life [114, 117, 118]. Studies on Resiliency Theory use three models of resilience—the compensatory, protective, and challenge models—to explain the processes by which promotive factors positively influence the adversity trajectories [114]. The compensatory model defends the idea of a promotive factor acting in an opposite direction of a risk factor on an outcome. The protective factor model highlights the moderating effect of assets and resources on the relationships between a risk factor and a negative outcome. The challenge model suggests that the exposure to moderate levels of a risk factor is associated with less negative, or even positive, outcomes, while low levels and high levels of a risk factor are associated with negative outcomes [114].
Recent studies on the impact of advantageous childhood experiences on adult health have been using the compensatory model of Resiliency Theory, defending that positive childhood experiences will have a direct influence on an outcome [117], counteracting the negative effects of adverse events [118]. The cumulative number of childhood positive experiences leading to resilience and better lifelong health are considered as counter-ACES, including positive parenting, school involvement, meaningful beliefs, and positive and close relationships with family, friends, and other adults [117, 119].
Positive and advantageous childhood experiences and supportive relationships may improve future social experiences and healthy relationships, protecting children against poor health and promoting well-being throughout life [119, 120]. To reduce health problems and improve the quality of life of vulnerable populations, it may be more important to increase counter-ACEs than decrease ACEs. Public health programs focusing on counter-ACEs are able to help families and communities to surround vulnerable children with counter-ACEs, such as parent-child attachment or household routines, helping to neutralize the negative effect of ACEs on children’s health and well-being [120].
Studying childhood maltreatment with a resiliency framework can be particularly important due to the harmful and long-term effects of violence in childhood. This framework allows us to analyze the positive and negative trajectories of children who experienced violence, to understand how maltreated and neglected children overcome the adverse experiences, and to explore the processes, moderators, and mechanisms that facilitate a positive adaptation to violence [121].
Previous studies highlight the important role of families, schools, and peers as well as of individuals’ self-regulation in promoting a positive developmental trajectory in children exposed to violence [113]. The existence of a supportive and stable carer is one of the most important protective factors associated with positive outcomes in this population [121]. Therefore, health promotion strategies directed to children living in violent contexts should be focused on strengthening supportive relationships across ecological contexts, including families, schools, and communities, and on the development of school-based programs aiming at developing children’s self-regulatory capacities [113].
In conclusion, there is a need to deepen the knowledge on childhood resilience to inform the design and development of public health intervention strategies and policies to relieve the impact of violence suffered by individuals during their developmental years, allowing them to achieve good health and quality of life. These strategies will give children living in adverse environments hope and tools to change their negative path, tackling costly social and health inequities. Building resilience in early childhood offers an opportunity to improve the quality of life of the next generation, enhance productivity, and reduce healthcare costs [122].
Growing up in a context of violence mostly perpetrated by the ones that should be the main protectors of the child by providing them with a healthy and safe environment may trigger a cascade of psychosocial vulnerabilities. The child may be vulnerable to being exposed to violence at home and then at school, and these experiences can be manifested in different ways. Regardless of the type of exposure to violence, it has a serious impact on child health and development. Although assessing violence experiences in cohort studies may be challenging, it is very relevant to include these questions in the cohort assessments. First, it is a human rights question; second, it impacts the child’s development and well-being; and third, it will impact long-term health. A longitudinal perspective will contribute to understanding the intersection of different violent experiences and their contribution to the production of health inequalities. In addition, we can explore the resilience factors in a life-course perspective, which will help to inform the design and development of interventions enhancing existing skills, encouraging healthy adjustment trajectories, and nurturing resilient adaptation.
The authors would like to acknowledge the vision of Professor Henrique Barros for always considering violence as a relevant topic for public health and including measures of violence in the cohort assessments.
Support for the completion of this work was provided by the European Regional Development Fund (ERDF) through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology (FCT), Portuguese Ministry of Science, Technology and Higher Education through the financing of the project “HIneC: When do health inequalities start? Understanding the impact of childhood social adversity on health trajectories from birth to early adolescence” (POCI-01-0145-FEDER-029567; PTDC/SAU-PUB/29567/2017), the Epidemiology Research Unit—Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (UIDB/04750/2020), the Associate Laboratory ITR (LA/P/0064/2020), and the individual researcher contract to SF (CEECIND/01516/2017).
The authors declare no conflict of interest.
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Several body of evidence show that distinct pathways of oxygen and nitrogen reactive species formation contribute to myocardial impairment. Abnormal mitochondrial morphology and energetics, evoked by abnormal Ca2+ handling, metabolic changes and oxidative stress, are observed in DCM, suggesting a pivotal role of mitochondrial dynamics in disease pathogenesis. In addition, insulin resistance compromises myocardial glucose uptake due to cellular depletion of glucose transporter proteins, together with increased myocardial uptake of free fatty acids and augmented triglyceride levels, which cause cardiomyocyte lipotoxicity. Finally, the state of chronic low-grade inflammation, a feature of obese type 2 diabetes, seems to also play a major role in DCM progression, whose mechanisms have been progressively disclosed. 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Biventricular failure is mostly an end-stage clinical situation of the heart failure syndrome. More recently, the rise in the incidence of right ventricular failure can be seen after the implantation of a left ventricular assist device. This chapter clarifies and presents pathophysiologic alterations in heart failure syndrome.",book:{id:"5425",slug:"cardiomyopathies-types-and-treatments",title:"Cardiomyopathies",fullTitle:"Cardiomyopathies - Types and Treatments"},signatures:"Kaan Kırali, Tanıl Özer and Mustafa Mert Özgür",authors:[{id:"155565",title:"Prof.",name:"Kaan",middleName:null,surname:"Kırali",slug:"kaan-kirali",fullName:"Kaan Kırali"},{id:"201164",title:"Dr.",name:"Tanıl",middleName:null,surname:"Özer",slug:"tanil-ozer",fullName:"Tanıl Özer"},{id:"201165",title:"Dr.",name:"Mustafa Mert",middleName:null,surname:"Özgür",slug:"mustafa-mert-ozgur",fullName:"Mustafa Mert Özgür"}]},{id:"35915",title:"Hemodynamics",slug:"hemodynamics",totalDownloads:4157,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"1840",slug:"the-cardiovascular-system-physiology-diagnostics-and-clinical-implications",title:"The Cardiovascular System",fullTitle:"The Cardiovascular System - Physiology, Diagnostics and Clinical Implications"},signatures:"Ali Nasimi",authors:[{id:"107284",title:"Dr.",name:"Ali",middleName:null,surname:"Nasimi",slug:"ali-nasimi",fullName:"Ali Nasimi"}]},{id:"23198",title:"Procedural Techniques of Coronary Angiography",slug:"procedural-techniques-of-coronary-angiography",totalDownloads:35302,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"266",slug:"advances-in-the-diagnosis-of-coronary-atherosclerosis",title:"Advances in the Diagnosis of Coronary Atherosclerosis",fullTitle:"Advances in the Diagnosis of Coronary Atherosclerosis"},signatures:"Jasmin Čaluk",authors:[{id:"31993",title:"Dr.",name:"Jasmin",middleName:null,surname:"Caluk",slug:"jasmin-caluk",fullName:"Jasmin Caluk"}]},{id:"30097",title:"Bradycardia Secondary to Cervical Spinal Cord Injury",slug:"bradycardia-secondary-to-cervical-spinal-cord-injury",totalDownloads:19289,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"947",slug:"cardiac-arrhythmias-new-considerations",title:"Cardiac Arrhythmias",fullTitle:"Cardiac Arrhythmias - 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",slug:"abdelhamid-mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. 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Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. 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