Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
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Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\n
Thank you all for being part of the journey. 5,000 times thank you!
\\n\\n
Now with 5,000 titles available Open Access, which one will you read next?
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
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"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
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Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\n
Seeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\n
Over these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\n
We are excited about the present, and we look forward to sharing many more successes in the future.
\n\n
Thank you all for being part of the journey. 5,000 times thank you!
\n\n
Now with 5,000 titles available Open Access, which one will you read next?
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7102",leadTitle:null,fullTitle:"Pneumonia",title:"Pneumonia",subtitle:null,reviewType:"peer-reviewed",abstract:"Pneumonia is an infectious disease of the pulmonary alveoli that leads to extensive morbidity and mortality. This book presents a comprehensive overview of this disease with chapters on hospital-acquired pneumonia, drug-related problems and hospital readmissions, secondary bacterial infections in viral pneumonia, and iron acquisition in pneumococci.",isbn:"978-1-83968-639-9",printIsbn:"978-1-83968-638-2",pdfIsbn:"978-1-83968-640-5",doi:null,price:100,priceEur:109,priceUsd:129,slug:"pneumonia",numberOfPages:86,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9fd70142814192dcec58a176749f1b60",bookSignature:"Nima Rezaei",publishedDate:"May 11th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",numberOfDownloads:388,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:null,hasAltmetrics:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 25th 2021",dateEndSecondStepPublish:"June 22nd 2021",dateEndThirdStepPublish:"August 21st 2021",dateEndFourthStepPublish:"November 9th 2021",dateEndFifthStepPublish:"January 8th 2022",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"80991",title:"Introductory Chapter: Pneumonia",doi:"10.5772/intechopen.103675",slug:"introductory-chapter-pneumonia",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Aysan Moeinafshar and Nima Rezaei",downloadPdfUrl:"/chapter/pdf-download/80991",previewPdfUrl:"/chapter/pdf-preview/80991",authors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"},{id:"454588",title:"Dr.",name:"Aysan",surname:"Moeinafshar",slug:"aysan-moeinafshar",fullName:"Aysan Moeinafshar"}],corrections:null},{id:"81266",title:"Hospital-Acquired Pneumonia",doi:"10.5772/intechopen.101236",slug:"hospital-acquired-pneumonia",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Pneumonia acquired during hospitalization is called nosocomial pneumonia (NP). Nosocomial pneumonia is divided into two types. Hospital-acquired pneumonia (HAP) refers to hospital-acquired pneumonia, whereas ventilator-associated pneumonia (VAP) refers to ventilator-associated pneumonia. Most clinical literature stresses VAP’s importance and associated mortality and morbidity, whereas HAP is not given enough attention even while being the most common cause of NP. HAP, like VAP, carries a high mortality and morbidity. HAP is the commonest cause of mortality from hospital-acquired infections. HAP is a common determinant for intensive care unit (ICU) admits with respiratory failure. Recent research has identified definite risk factors responsible for HAP. If these are prevented or modified, the HAP incidence can be significantly decreased with improved clinical outcomes and lesser utilization of the health care resources. The prevention approach will need multiple strategies to address the issues. Precise epidemiological data on HAP is deficient due to limitations of the commonly used diagnostic measures. The diagnostic modalities available in HAP are less invasive than VAP. Recent infectious disease society guidelines have stressed the importance of HAP by removing healthcare-associated pneumonia as a diagnosis. Specific differences exist between HAP and VAP, which are gleaned over in this chapter.",signatures:"Sachin M. Patil",downloadPdfUrl:"/chapter/pdf-download/81266",previewPdfUrl:"/chapter/pdf-preview/81266",authors:[{id:"352750",title:"Dr.",name:"Sachin M.",surname:"Patil",slug:"sachin-m.-patil",fullName:"Sachin M. Patil"}],corrections:null},{id:"78526",title:"Pneumonia: Drug-Related Problems and Hospital Readmissions",doi:"10.5772/intechopen.100127",slug:"pneumonia-drug-related-problems-and-hospital-readmissions",totalDownloads:236,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Pneumonia is one of the most common infectious diseases and the fourth leading cause of death globally. According to US statistics in 2019, pneumonia is the most common cause of sepsis and septic shock. In the US, inpatient pneumonia hospitalizations account for the top 10 highest medical costs, totaling $9.5 billion for 960,000 hospital stays. The emergence of antibiotic resistance in the treatment of infectious diseases, including the treatment of pneumonia, is a globally alarming problem. Antibiotic resistance increases the risk of death and re-hospitalization, prolongs hospital stays, and increases treatment costs, and is one of the greatest threats in modern medicine. Drug-related problems (DRPs) in pneumonia - such as suboptimal antibiotic indications, prolonged treatment duration, and drug interactions - increase the rate of antibiotic resistance and adverse effects, thereby leading to an increased burden in treatment. In a context in which novel and effective antibiotics are scarce, mitigating DRPs in order to reduce antibiotic resistance is currently a prime concern. A variety of interventions proven useful in reducing DRPs are antibiotic stewardship programs, the use of biomarkers, computerized physician order entries and clinical decision support systems, and community-acquired pneumonia scores.",signatures:"Kien T. Nguyen, Suol T. Pham, Thu P.M. Vo, Chu X. Duong, Dyah A. Perwitasari, Ngoc H.K. Truong, Dung T.H. Quach, Thao N.P. Nguyen, Van T.T. Duong, Phuong M. Nguyen, Thao H. Nguyen, Katja Taxis and Thang Nguyen",downloadPdfUrl:"/chapter/pdf-download/78526",previewPdfUrl:"/chapter/pdf-preview/78526",authors:[{id:"84603",title:"Dr.",name:"Dyah A.",surname:"Perwitasari",slug:"dyah-a.-perwitasari",fullName:"Dyah A. Perwitasari"},{id:"274573",title:"Ph.D.",name:"Thang",surname:"Nguyen",slug:"thang-nguyen",fullName:"Thang Nguyen"},{id:"345414",title:"Prof.",name:"Kien T.",surname:"Nguyen",slug:"kien-t.-nguyen",fullName:"Kien T. Nguyen"},{id:"429440",title:"Dr.",name:"Thu P.M.",surname:"Vo",slug:"thu-p.m.-vo",fullName:"Thu P.M. Vo"},{id:"429454",title:"Prof.",name:"Suol T.",surname:"Pham",slug:"suol-t.-pham",fullName:"Suol T. Pham"},{id:"429455",title:"Prof.",name:"Chu X.",surname:"Duong",slug:"chu-x.-duong",fullName:"Chu X. Duong"},{id:"429456",title:"MSc.",name:"Ngoc H.K.",surname:"Truong",slug:"ngoc-h.k.-truong",fullName:"Ngoc H.K. Truong"},{id:"429457",title:"MSc.",name:"Dung T.H.",surname:"Quach",slug:"dung-t.h.-quach",fullName:"Dung T.H. Quach"},{id:"429458",title:"BSc.",name:"Thao N.P.",surname:"Nguyen",slug:"thao-n.p.-nguyen",fullName:"Thao N.P. Nguyen"},{id:"429459",title:"MSc.",name:"Van T.T.",surname:"Duong",slug:"van-t.t.-duong",fullName:"Van T.T. Duong"},{id:"429460",title:"Dr.",name:"Phuong M.",surname:"Nguyen",slug:"phuong-m.-nguyen",fullName:"Phuong M. Nguyen"},{id:"429461",title:"Prof.",name:"Thao H.",surname:"Nguyen",slug:"thao-h.-nguyen",fullName:"Thao H. Nguyen"},{id:"429462",title:"Prof.",name:"Katja",surname:"Taxis",slug:"katja-taxis",fullName:"Katja Taxis"}],corrections:null},{id:"79759",title:"Examining the Executioners, Influenza Associated Secondary Bacterial Pneumonia",doi:"10.5772/intechopen.101666",slug:"examining-the-executioners-influenza-associated-secondary-bacterial-pneumonia",totalDownloads:98,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Influenza infections typically present mild to moderate morbidities in immunocompetent host and are often resolved within 14 days of infection onset. Death from influenza infection alone is uncommon; however, antecedent influenza infection often leads to an increased susceptibility to secondary bacterial pneumonia. Bacterial pneumonia following viral infection exhibits mortality rates greater than 10-fold of those of influenza alone. Furthermore, bacterial pneumonia has been identified as the major contributor to mortality during each of the previous four influenza pandemics. Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pyogenes are the most prevalent participants in this pathology. Of note, these lung pathogens are frequently found as commensals of the upper respiratory tract. Herein we describe influenza-induced host-changes that lead to increased susceptibility to bacterial pneumonia, review virulence strategies employed by the most prevalent secondary bacterial pneumonia species, and highlight recent findings of bacterial sensing and responding to the influenza infected environment.",signatures:"Timothy R. Borgogna and Jovanka M. Voyich",downloadPdfUrl:"/chapter/pdf-download/79759",previewPdfUrl:"/chapter/pdf-preview/79759",authors:[{id:"424031",title:"Dr.",name:"Timothy R.",surname:"Borgogna",slug:"timothy-r.-borgogna",fullName:"Timothy R. Borgogna"},{id:"441116",title:"Dr.",name:"Jovanka M.",surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich"}],corrections:null},{id:"80914",title:"Proteins of Streptococcus pneumoniae Involved in Iron Acquisition",doi:"10.5772/intechopen.101668",slug:"proteins-of-em-streptococcus-pneumoniae-em-involved-in-iron-acquisition",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Streptococcus pneumoniae is a human pathogen bacterium capable of using hemoglobin (Hb) and haem as a single iron source but not in presence of lactoferrin. This bacterium has developed a mechanism through the expression of several membrane proteins that bind to iron sources, between them a lipoprotein of 37 kDa called Spbhp-37 (Streptococcus pneumoniae haem-binding protein) involved in iron acquisition. The Spbhp-37 role is to maintain the viability of S. pneumoniae in presence of Hb or haem. This mechanism is relevant during the invasion of S. pneumoniae to human tissue for the acquisition of iron from hemoglobin or haem as an iron source.",signatures:"José de Jesús Olivares-Trejo and María Elizbeth Alvarez-Sánchez",downloadPdfUrl:"/chapter/pdf-download/80914",previewPdfUrl:"/chapter/pdf-preview/80914",authors:[{id:"322007",title:"Dr.",name:"Maria Elizbeth",surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez"},{id:"422063",title:"Prof.",name:"José de Jesús",surname:"Olivares-Trejo",slug:"jose-de-jesus-olivares-trejo",fullName:"José de Jesús Olivares-Trejo"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"6",series:{id:"6",title:"Infectious Diseases",issn:"2631-6188",editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"11",institution:null}}},tags:[{id:"54",label:"covid-19 book program"}]},relatedBooks:[{type:"book",id:"5975",title:"Physiology and Pathology of Immunology",subtitle:null,isOpenForSubmission:!1,hash:"b31eea21dfa90b753604f34bf1c0b8a5",slug:"physiology-and-pathology-of-immunology",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/5975.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7475",title:"Immunogenetics",subtitle:null,isOpenForSubmission:!1,hash:"dd50ca8b9158dc45b6b23fcae43d1daa",slug:"immunogenetics",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/7475.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"963",title:"Hodgkin's Lymphoma",subtitle:null,isOpenForSubmission:!1,hash:"a107026375308f4f7f45cf2ed535b4e8",slug:"hodgkin-s-lymphoma",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/963.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8043",title:"Monoclonal Antibodies",subtitle:null,isOpenForSubmission:!1,hash:"91da3371c910d66deb7b8c434948b834",slug:"monoclonal-antibodies",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/8043.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8805",title:"Toll-like Receptors",subtitle:null,isOpenForSubmission:!1,hash:"ae025ebfc36fd7ebbe1cd53ea11c4dc1",slug:"toll-like-receptors",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/8805.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7020",title:"Thymus",subtitle:null,isOpenForSubmission:!1,hash:"d5e32bf6c19eb7408108a84bc3d37948",slug:"thymus",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/7020.jpg",editedByType:"Edited by",editors:[{id:"116250",title:"Dr.",name:"Nima",surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"825",title:"Current Topics in Tropical Medicine",subtitle:null,isOpenForSubmission:!1,hash:"ef65e8eb7a2ada65f2bc939aa73009e3",slug:"current-topics-in-tropical-medicine",bookSignature:"Alfonso J. 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\r\n\tIn the first part of this book, the molecular profiles especially of the high-grade ovarian cancer will be described, and especially the clinical implications will be discussed.
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\r\n\tLast but not least, the book will focus on systemic treatment beginning with chemotherapy like neoadjuvant strategies and ending with targeted treatment like PARP-inhibition and new aspects to immunobiological therapies.
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Multidimensional Knowledge-Centric System Analytics",slug:"generating-scientifically-proven-knowledge-about-ontology-of-open-systems-multidimensional-knowledge",signatures:"Tamara L. Kachanova, Boris F. Fomin and Oleg B. Fomin",authors:[{id:"119582",title:"Prof.",name:"Boris",middleName:null,surname:"Fomin",fullName:"Boris Fomin",slug:"boris-fomin"},{id:"219314",title:"Prof.",name:"Tamara",middleName:null,surname:"Kachanova",fullName:"Tamara Kachanova",slug:"tamara-kachanova"},{id:"219315",title:"MSc.",name:"Oleg",middleName:null,surname:"Fomin",fullName:"Oleg Fomin",slug:"oleg-fomin"}]},{id:"58350",title:"Semantic Remote Sensing Scenes Interpretation and Change Interpretation",slug:"semantic-remote-sensing-scenes-interpretation-and-change-interpretation",signatures:"Fethi Ghazouani, Imed Riadh Farah and Basel Solaiman",authors:[{id:"219646",title:"Ph.D.",name:"Fethi",middleName:null,surname:"Ghazouani",fullName:"Fethi Ghazouani",slug:"fethi-ghazouani"},{id:"225912",title:"Prof.",name:"Imed Riadh",middleName:null,surname:"Farah",fullName:"Imed Riadh Farah",slug:"imed-riadh-farah"},{id:"225914",title:"Prof.",name:"Basal",middleName:null,surname:"Solaiman",fullName:"Basal Solaiman",slug:"basal-solaiman"}]},{id:"58822",title:"Systematic Unfoldment of Differential Ontology from Qualitative Concept of Information",slug:"systematic-unfoldment-of-differential-ontology-from-qualitative-concept-of-information",signatures:"Stein E. 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\n
1. Introduction
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Biowaste can be defined as a mixture of vegetal and animal biomasses that are residues of human activities. It contains large carbon-based macromolecules that can be used as a renewable material for energy production, carbon sequestration, and soil conditioner and fertilizer. Nevertheless, biowaste management requires a specific attention in order to increase the overall sustainability of the treatment and to define guidelines to increase its effective recovery. In Europe, more than 118 millions of tons of biodegradable waste are produced each year; only 25% of this amount is collected and sent to the given recovery option [1]. The recovery treatments are mainly based on biological processes: the most used is the composting (low capital and operating cost, low value of products) followed by the integrated anaerobic/aerobic digestion (medium–high capital cost, low operating cost, medium value of products, depending of country incentives program). Although the composting is widely used, its sustainability is not always guaranteed because of long process time, large areas needed for storage and processing, environmental impact due to annoying odors released by diffuse and fugitive emissions other than a not favorable ratio between the value of the product (compost), and the cost of the process. The recourse to an anaerobic digestion as preliminary stage allows to improve the overall process by permitting the production of biogas in addition to the compost. The main limitation of biological process is the low economic value of the compost obtained from biowaste coming from separate collection of municipal waste. This important source of biodegradable matter is often contaminated by other waste with a fraction between 10 and 25%, depending on the waste collection system adopted for the separate collection [2, 3, 4]. The presence of this fraction, generally represented by plastics and metals, can further decrease the economic value of the compost that is sold at a price between 0 and 3 €/Mg [5].
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An alternative to compost production is the transformation of the biowaste, including digestate, into different products, either solid, liquid, or gaseous obtained by means of thermochemical treatments. Depending on the specific production process and feedstock, the obtained products are different: thermal decomposition of wood, peat, or some related natural organic materials produces charcoal [6, 7]; the torrefaction produces biocoal [8]; if the charred organic matter is applied to soil with the intent to improve soil properties, it is called biochar [9]; moreover, the product of hydrothermal pyrolysis, is called hydrochar [10].
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The hydrothermal pyrolysis (HTC) converts all substrates containing carbohydrates and molecules, including biowaste, into hydrochar, gas, and leachate by means of extraction of nitrogen and oxygen in a subcritical water environment [11]. The HTC stage can be applied to the fresh biowaste or to the digestate produced by the anaerobic digestion plants. In this latter case, the integration is able to avoid the aerobic treatment that is time- and space-consuming and obtain a high-added value product, in a limited footprint. The other waste stream that needs to be exploited is the not biodegradable waste; the fate of this waste is the landfilling or the energy recovery by combustion [12], and the gate fee for its disposal strongly increased in the last years. The thermochemical processes applicable to this kind of waste are pyrolysis and gasification: the latter is preferable since it is energetically self-sustainable and allows to produce both heat and electricity [13, 14, 15]. The main advantage of gasification is the limited size of the plant and the possibility to install it with capacities starting from few hundreds of kilograms in an hour.
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The present chapter aimed to demonstrate the feasibility of integration between small-scale thermochemical processes and the biowaste biological treatment facility with the target to reduce the waste production, increase the energy recovery, and, more in general, increase the sustainability of the plant.
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2. Configuration of the base case anaerobic digestion facility
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2.1 Description of the unit processes
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The standard configuration of anaerobic digestion facility consists of the following sections:
Acceptance, weight, and discharge of biowaste from the lorries
Preliminary mechanical treatment and sorting
Mixing between substrates having different moisture content and structure (e.g., lignin-based biowaste is added to food biowaste to increase permeability, moderate moisture content, and modify the C/H ratio)
Pulping (only in case of wet digestion processes)
Anaerobic digestion into one (unique bioreactor) or two stages (two in series reactors for hydrolysis and acetogenesis/methanation steps)
Leachate recirculation and storage before treatment or delivery to the water treatment plant
Aerobic stabilization of digestate (composting)
Mechanical refining and foreign matter removal
\n\n
The data and the information utilized in this work are based on a full-scale facility that utilizes a dry-batch technology to perform the anaerobic digestion, and it is integrated with the composting plant to obtain the mineralization of the digestate. The facility is located in the industrial area of Naples, Italy [5], and treat biowaste from household separate collection and restaurants.
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The block diagram of the integrated processes is reported in Figure 1.
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Figure 1.
Block diagram and unit processes included in the reference case.
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With reference to the unit processes labels reported in Figure 1, a short description is reported in the following paragraphs.
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2.1.1 Pretreatment and sorting
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The organic fraction of municipal solid waste contains a certain amount of foreign matter constituted by inorganic and organic nonbiodegradable materials such as glass, ceramic, metals, plastic bags, plastic closures, wires, etc. The size distribution of this fraction ranges from few millimeters up to several centimeters, allowing the removal of large objects by means of manual sorting and sieving in a trommel. Generally, the minimum size of the holes installed to remove the foreign matter is 5 cm. A photo of the waste removed by using the mechanical sorting after the bag opener (light-intensity shredding) is reported in Figure 2.
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Figure 2.
Waste removed by the biowaste in the pretreatment stage.
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2.1.2 Anaerobic digestion
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The anaerobic digestion is then carried out by using eight batch reactors operated by recurring to an operation mode by including the following phases: emptying (a), filling and mixing (b), and reaction (c). The reactors are sequentially operated in order to have a semicontinuous operation. Steps (a) and (b) require a couple of days to be carried out, that is why each bioreactor starts the reaction phase with a delay of two days; the reaction phase has a duration of 28 days. Each reactor is filled with about 200 t of fresh biowaste after the removal of a part of the digestate formed by the preceding cycle. The digestate remaining in the batch reactor (about 50%) is mixed with the fresh one, acting as an inoculum for the microbial growing kinetics.
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The process is a dry-batchwise since the solids fraction in the reacting mass is larger than 30%. The level of moisture that ensures the microbial activity inside the reactors is maintained by feeding the leachate collected from the bottom of each reactor at the top of it. It is important to highlight that the reactors are not stirred and that heat transfer and water percolation are limiting factors for the process: without the recirculation of preheated leachate and the mixing with activated digestate, the process shall not occur in an appreciable way.
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2.1.3 Cogeneration
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The biogas generated by the anaerobic bioreactors resulted to be 5,040,000 Nm3 per year, corresponding to a production yield of 140 Nm3/t. This biogas is conditioned in order to remove hydrogen sulfide, ammonia, and moisture that results to be 5% in the final gas. The composition of biogas is variable, but the mean values are 60%v of methane and 40%v of carbon dioxide. The combustion of biogas is carried out in two 500 kWe Jenbacher engines that produce the electricity introduced in the public grid. The corresponding produced heat is recovered and used to enhance the composting process rate and drying the final compost.
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2.1.4 Leachate storage tank
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The leachate is produced during the anaerobic digestion thanks to the percolation of interstitial water from the substrate; a part of leachate is heated and recirculated inside the anaerobic bioreactors in order to keep the substrate humidified. The rest of the leachate is stored in a tank having a volume of 1000 m3 and sent to the external facility to be treated and disposed. The leachate corresponds to about 30–40% of the initial biowaste.
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2.1.5 Composting
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The aerobic stabilization of the unconverted volatile solids occurs in order to mineralize the substrate for a period of 90 days. The composting process requires air not only for chemical oxidation of volatile solids but also for the heat removal and odor dilution in the indoor environment. The aerobic treatment requires 16,000 Nm3 of air each Mg of digestate; that means that, in this specific case, 29,000 Nm3/h need to be continuously extracted from the warehouse and sent to the air treatment modules in order to be cleaned up. The air treatment system receives this stream containing odorigenous molecules including organics, acids, and ammonia; it is composed of a scrubbing unit followed by two biofilters; this system is designed in order to remove odor molecules from the conveyed air stream before the diffusion in the outdoor environment. Electricity consumption for air recirculation, biofilter replacement, and wastewater treatment are expenses for this stage of the overall process.
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The aerobic stabilization is followed by the maturation and refining phases (F + G). The refining process aims to remove the foreign materials and obtain a homogenized size distribution. The moisture level in the compost is lowered at 5% by using the heat recovered by section C. This phase is required in order to produce a compost that can be sold on the market of fertilizers.
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2.2 The critical issues of the present configuration
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The mass balance of the plant in the present configuration is reported in Table 1. Data are in agreement with those obtained by other anaerobic facilities assessed in the scientific and technical literature [16, 17, 18].
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Input
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Intermediate
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Output
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Biowaste
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Digestate
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Waste
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Leachate
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Biogas
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Compost
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\n\n\n
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Mass rate, Mg/day
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35,000
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15,600
\n
4200
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13,278
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12.34
\n
4471
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Specific indicator, Mg/Mg
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—
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0.45
\n
0.12
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0.38
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0.13
\n
0.13
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Table 1.
Mass balance of the reference facility.
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The amount of produced waste, whose amount is depending on the separate collection performance, and that of leachate both represent a negative feature as well as for environmental and economic reasons: the delivery and disposal of leachate at external facilities requires about 50 €/Mg, while the tipping fee of the waste is more than 150 €/Mg. The impact of transportation should also be included in the environmental impact assessment and in the cost evaluation since the distance between treatment plant for waste and leachate can be quite large.
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Moreover, the present configuration is economically sustainable only if electricity and/or biomethane is sustained by incentives. The value of green certificates for biogas is variable, but for 1 MW biogas facilities, an indicative value of 104 €/MWh can be used [19].
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Despite the incentives for the obtained products (electricity/methane), and considering that the compost has a very low value, the cost of waste disposal and that of composting (aeration) result in the increase of biowaste tipping fee that, in Italy, leads the cost of the management of separate collected waste over 190 €/t [20]. Other countries in Europe have lower tipping fees for biowaste treatment due to less restrictions about digestate use (e.g., it is not mandatory to mineralize the digestate prior to the soil scattering) and a lower cost of waste disposal due to an efficient network of waste treatment facilities. This latter cost is anyway continuously increased in the last years due to the difficulty to process inside the Europe borders the plastic waste [12].
\n
Based on these considerations and on the European guidelines about the proximity criterion, an improvement of the industrial layout of the facility can be proposed in order to reduce the impact and the cost of the whole system. This improvement is based on the integration inside the facility boundary of the processes that allow to:
Treat the digestate in a more efficient way.
Exploit the not biodegradable waste by avoiding disposing it outside the facility boundary.
Treat the wastewater by using the heat produced by the integrated processes.
\n\n
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3. Configuration of the integrated anaerobic digestion facility
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3.1 Description of the unit processes of the alternative configuration
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The configuration of anaerobic digestion facility presented in Figure 1 has been integrated with unit processes allowing:
A sustainable production of a stable product (hydrochar) useful for agriculture purposes in place of compost
The energy and heat production from the waste by minimizing the amount of waste to be disposed outside the facility boundary and its economic cost
The treatment of leachate by using an effective evaporation method carried out by using the accumulated sensible heat and the recovered heat from the waste conversion
\n\n
The unit processes able to reach the abovementioned targets have been reported in the integrated block diagram in Figure 3 and described in detail in the following paragraphs.
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Figure 3.
Block diagram and unit processes of the proposed integrated facility.
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3.1.1 Pulping and filtering
\n
The digestate contains about 70% of moisture, as resulted from the mean values of the proximate and ultimate analyses reported in Table 2 [21].
\n
\n
\n
\n
\n
\n
\n
\n\n
\n
Carbon, %
\n
Hydrogen, %
\n
Nitrogen, %
\n
Oxygen, %
\n
Ash, %
\n
Moisture, %
\n
\n\n\n
\n
32.82 ± 1.2%
\n
4.25 ± 0.2%
\n
2.11 ± 0.08%
\n
33.93 ± 3.2%
\n
26.89 ± 3.6%
\n
69.85 ± 2.4%
\n
\n\n
Table 2.
Proximate and ultimate analyses of digestate (dry basis).
\n
In this stage, it is conditioned in order to be suitable to undergo a thermal process aimed to hydrochar production, instead of the aerobic biological process aimed to compost production.
\n
The hydrochar production process (F) occurs with very good efficiency if the organic fraction of digestate is in a pulping state, well mixed with water, and with a given water/dry matter ratio; this means that the mixing and pulping preprocessing has to be realized.
\n
The pulping process allows to deal with another negative feature of digestate composition: the presence of foreign matter (inorganic or not reactive organics). In fact, a critical characteristic of digestate is the content of foreign matter such as glass, stones, and plastics that cannot be removed by the sorting made in the pretreatment stage where only the coarser fraction of foreign matter having a mean size larger than 5 mm is removed during the presorting; the remaining amount is not negligible and can be responsible of a dramatic decrease of the value of the final product if not removed. The pulping process between the digestate and the added water allows to separate the foreign matter by filtering the mixture following standard techniques applied in well-known wet anaerobic processes pretreatment. In this specific case, the digestate is mixed with the leachate produced by the anaerobic digestion in such a way to prepare a homogeneous pulp by respecting a given value of the parameter R (Eq. 1). In Eq. 1, \n\n\nw\ndigestate\n\n\n is the weight of the digestate and \n\n\nx\n\n\nH\n2\n\nO\n,\ndigestate\n\n\n\n is the mass fraction of the moisture in the digestate.
The pulping process can be favored by the preheating of leachate at about 70–80°C and by an intense shredding of the pulp itself. In this way, the foreign matter can be removed with very high efficacy (Figure 4, right) by floating (low-density fraction), by sedimentation (high-density fraction), and by sieving. The pulping creates the best conditions for this filtering/cleaning process and for the following reacting process reported in step F.
\n
Figure 4.
Photos of digestate (left) and pulp (right).
\n
\n
\n
3.1.2 Hydrothermal carbonization
\n
The hydrothermal carbonization (HTC) is a thermochemical process occurring in the presence of subcritical, liquid water: the target of this “wet or hydrous pyrolysis” is making products with higher carbon content, that are biologically inert, and with physical characteristics that make them suitable for agricultural or industrial purposes. The product obtained from the hydrous pyrolysis is called hydrochar to distinguish it from the biochar that is obtained by dry pyrolysis [22, 23]. During the hydrothermal process, the volatile solids contained in the digestate are surrounded by water which is kept at liquid state by allowing the pressure to rise until the endogenous value reached at the reactor temperature. The production of gases is very limited (1–5%), while dissolution of elements in the water can have a certain extent such as 5–20% [24]. The carbonization requires a reaction time of hours (1–12 h), depending on the reaction’s temperature utilized, and occurs in a closed reactor by allowing the elimination of diffuse release of odors. Moreover, the high temperature destroys pathogens and active organic molecules. The resulted hydrochar may contribute to climate change mitigation and soil amelioration [24]. The HTC process is basically a decomposition process where chemical reactions such as hydrolysis, dehydration, decarboxylation, aromatization, and condensation occur [25]. The hydrolysis’s activation energy is lower than the other reactions; this lowers the decomposition temperature of the main constituents of biomasses: cellulose and lignin, for example, decompose between 180 and 220°C.
\n
The reactor where the HTC is carried out is a batch reactor, filled with the pulp obtained by mixing, stirring, and filtering digestate and leachate and heated up to the reaction temperature in a given heating time. A schematic process flow diagram of the HTC section is reported in Figure 5.
\n
Figure 5.
Process flow diagram of HTC section.
\n
The pressure inside the reactor is determined by the temperature setup for the reaction; the temperature vs. pressure correlation can be obtained by the Antoine equation.
\n
In the specific case of this simulation, the HTC operating conditions are reported in Table 3.
\n
\n
\n
\n
\n\n
\n
Temperature of reaction
\n
°C
\n
220
\n
\n\n\n
\n
Pressure
\n
Bar
\n
19
\n
\n
\n
Water/digestate ratio
\n
Mg/Mg
\n
0.90
\n
\n
\n
Reaction time
\n
h
\n
6.0
\n
\n
\n
Reactor heating time
\n
h
\n
0.4
\n
\n
\n
Reactor charge-discharge time
\n
h
\n
1.0
\n
\n
\n
Total treatment time
\n
h
\n
7.4
\n
\n\n
Table 3.
HTC reactor and process parameters.
\n
\n
\n
3.1.3 Evaporator
\n
This stage realizes the evaporation of water under the form of steam by using the pressure difference between the reactor and the evaporator and the sensible heat of the liquid water. The evaporation allows to realize the separation of the pure water under the form of vapor from a concentrated flow, having a higher boiling temperature. The concentrated flow is rich in nitrogen and carbon; it is sterile and could be used as fertilizer, in case the regulations allow this application. The worst case is to consider it as leachate, as in the case of Figure 3. The steam can be condensed or lost in the atmosphere, depending on specific cases.
\n
\n
\n
3.1.4 Dewatering and drying
\n
The wet hydrochar is sent to dewatering, which is quite efficient due to its hydrophobia [26], and finally dried.
\n
\n
\n
3.1.5 Gasification
\n
The waste produced by the anaerobic digestion facility consists mainly of plastic bags and dishes, foils, and a limited amount of metals. It is basically a combustible material having a moisture content until 20% and it is very dirty. Its fate is the landfilling or energy recovery in large incineration plants.
\n
The integration of the AD plant with a small-scale gasifier allows to reduce the disposal costs and the production of electricity and heat necessary for the other processes.
\n
The gasification unit basically consists of a downdraft reactor equipped with a fixed bed as support for the primary reactions of the combustible material with water and air, three plasma torches aligned with the bed surface, a secondary zone where homogeneous reactions take place, and a secondary stream of air that is added to favor the reactions’ completion. The gasification reactions occurring on the plastic-based waste are responsible of a large production of hydrocarbons and aromatics (PAHs), partly transformed into tar, that need to be minimized in the syngas than the primary and secondary methods [13, 15, 27, 28]. In this specific case, the minimization of tar content is guaranteed by a mechanism of thermal cracking coupled with the saturation of produced radicals promoted in a secondary cracking reactor, located at syngas exit. The thermal cracking is realized by obligating the syngas by passing throughout a plasma plume composed of oxygen and hydroxyl radicals.
\n
\n
\n
3.1.6 Energy production
\n
The syngas is then sent to a cogeneration system to produce electricity and heat. Data related to the production of energy are reported in the following paragraphs.
\n
A possible alternative is to convert the syngas into heat and use it to feed the leachate treatment process and increase the evaporation yield.
\n
\n
\n
\n
3.2 Assessment of the unit processes of the alternative configuration
\n
\n
3.2.1 HTC mass and energy balance
\n
With reference to the section of the plant reported in Figure 3 and destined to the hydrochar production and thickening of leachate, the mass balance is reported in Table 4. The flow ID are referred to in Figure 3.
\n
\n
\n
\n
\n
\n
\n\n
\n
Flow ID
\n
From
\n
To
\n
Mg/year
\n
Description
\n
\n\n\n
\n
F8
\n
B
\n
E
\n
15,600
\n
Digestate
\n
\n
\n
F6
\n
D
\n
E
\n
14,278
\n
Leachate
\n
\n
\n
F9
\n
E
\n
F
\n
29,878
\n
Slurry
\n
\n
\n
F17
\n
J
\n
out
\n
2526
\n
Hydrochar (4.3% impurities)
\n
\n
\n
F18
\n
G
\n
out
\n
19,437
\n
Gas and vapor
\n
\n
\n
F19
\n
G
\n
out
\n
6281
\n
Leachate (concentrate)
\n
\n\n
Table 4.
HTC mass balance.
\n
The yield of hydrochar referred to the initial biowaste results to be 7%. The amount is quite similar to the compost yield, obtained by using the aerobic stabilization instead of the HTC process. The main differences are the following:
The HTC process requires three cycles by day, each as long as 6 hours, and two closed batch reactors to reach the given yield.
The HTC process does not emit odors and fugitive/diffuse emissions.
The HTC process requires an area quite lower than that necessary for composting.
The HTC can be conveniently coupled to a leachate treatment plant based on the evaporation/thickening standard processes available in the industrial market by using the heat content of liquid/vapor at the reactor outlet.
The energy balance of the HTC section is proposed in Table 5.
\n\n
\n
\n
\n
\n
\n
\n
\n\n
\n
\n
F (slurry heating)
\n
F (slurry reaction)
\n
Evaporation
\n
\n
\n
From
\n
E
\n
F
\n
F
\n
F
\n
F
\n
\n\n\n
\n
To
\n
F
\n
F
\n
F
\n
J
\n
F
\n
\n
\n
ID
\n
F9
\n
F9
\n
\n
F18
\n
F18
\n
\n
\n
Mass amount (for each cycle and reactor)
\n
16.06
\n
16.06
\n
16.06
\n
13.01 (liquid)
\n
10.19 (steam)
\n
\n
\n
Physical state
\n
l
\n
l
\n
l
\n
l
\n
g
\n
\n
\n
P, bar
\n
1.5
\n
42.6
\n
42.6
\n
42.6
\n
1.0
\n
\n
\n
T, °C
\n
43.8
\n
220.0
\n
220.0
\n
220.0
\n
105.0
\n
\n
\n
Flow enthalpy, MJ
\n
1242
\n
15,162
\n
1213
\n
11,661
\n
25,581
\n
\n
\n
Reaction enthalpy, MJ
\n
\n
\n
−1886
\n
\n
\n
\n
\n
Enthalpy to be provided, MJ
\n
13,920
\n
Negligible
\n
13,920
\n
\n\n
Table 5.
Evaluation of enthalpy flows for the unit processes E and F.
\n
The heat necessary for the heating of the slurry from the input temperature (exit of filter) up to 220°C is 866 MJ/Mg (at 42.6 bar); once the reaction temperature is reached, the carbonization begins by absorbing heat from the environment until exothermic reactions begin. The heating time has been fixed in 0.4 h (1440 sec), so an installed heating power of about 10 MW is necessary to provide the heat in the specified time interval.
\n
The thermal energy necessary to provide for the evaporation of water has been obtained by subtracting that requested to bring the water into vapor phase at 100°C and 1 bar to the thermal energy of the water medium present in the reactor. The amount of heat to carry out this process is 1366 MJ/Mg that corresponds to a thermal power of 9.7 MW, by assuming an evaporation time equal to that necessary for slurry’s heating. By using the energy content of water after the reactions are completed, it is possible to obtain the evaporation for about 78% of water (10.19/13.01); the remaining fraction remains in the liquid form by forming a thick leachate with solute.
\n
The hydrochar can be separated by water, by centrifugation, or by other standard dewatering systems.
\n
The most important feature is that the leachate produced by the facility is reduced at 44% of that produced by anaerobic digestion sector, without increase of thermal heat, but that used for HTC reaction.
\n
Further evaporation is technically possible and can be also economically feasible if heat demand is fulfilled by the third section of the plant: the gasification with energy recovery.
\n
The overall feedstock energy balance is reported in Table 6.
\n
\n
\n
\n
\n
\n\n
\n
\n
Mass flow, Mg/year
\n
Energy content, HHV, MJ/Mg
\n
Energy flow, MJ/day
\n
\n\n\n
\n
Raw biowaste
\n
36,000.0
\n
7437
\n
892,392
\n
\n
\n
Waste
\n
4320.0
\n
18,658
\n
268,673
\n
\n
\n
Biowaste
\n
31,680.0
\n
5906
\n
623,719
\n
\n
\n
Of which biodegradable
\n
30,600.0
\n
5456
\n
556,551
\n
\n
\n
Of which foreign matter
\n
1080.0
\n
18,658
\n
67,168
\n
\n
\n
\nTOTAL IN (AD)\n
\n
\n31,680.0\n
\n
\n
\n
\n
\n
Biogas
\n
6122.4
\n
18,380
\n
375,100
\n
\n
\n
Leachate
\n
14,277.6
\n
\n
\n
\n
\n
Digestate
\n
11,280.0
\n
6612
\n
248,619
\n
\n
\n
Of which foreign fraction in digestate (nonbiodegradable)
\n
1080.0
\n
18,658
\n
67,168
\n
\n
\n
\nTOTAL IN (pulper)\n
\n
\n28,218.2\n
\n
\n
\n
\n
\n
Digestate
\n
11,280.0
\n
6612
\n
248,619
\n
\n
\n
Added water/leachate
\n
16,938.2
\n
\n
\n
\n
\n
Removed foreign matter
\n
972.0
\n
18,658
\n
60,451
\n
\n
\n
Mixture
\n
27,246.2
\n
2072
\n
188,168
\n
\n
\n
Of which water
\n
24,044.6
\n
\n
\n
\n
\n
Of which organic
\n
3093.6
\n
17,596
\n
181,451
\n
\n
\n
Of which foreign matter
\n
108.0
\n
18,658
\n
6717
\n
\n
\n
\nTOTAL IN (HTC)\n
\n
\n27,246.2\n
\n
\n
\n
\n
\n
Gas
\n
624.2
\n
\n
\n
\n
\n
Liquid
\n
24,096.4
\n
\n
\n
\n
\n
Hydrochar (dry)
\n
2525.6
\n
20,766
\n
174,817
\n
\n
\n
Of which foreign fraction
\n
108.0
\n
18,658
\n
6717
\n
\n
\n
\nTOTAL OUT (HTC)\n
\n
\n27,246.2\n
\n
\n
\n
\n\n
Table 6.
Energy balance.
\n
The energy balance shows in brief that:
The biogas contains 42% of the initial feedstock energy content
The removed waste contains 37% of the initial feedstock energy content
The hydrochar contains 20% of the initial feedstock energy content
\n\n
The energy content of waste corresponds to about 3800 MW of chemical energy that can be used to produce energy by means of a gasification process, described in the following paragraph.
\n
\n
\n
3.2.2 Gasification mass and energy balance
\n
With reference to the section of the plant reported in Figure 3 and destined to the conversion of waste into energy and heat, the data in Table 7 are the basis for calculation. Data refer to the the typical waste resulting from the sorting of biowaste treated in the reference facility, just before being fed to digestors. These data are the starting point for calculation of calorific value, stoichiometric oxygen demand, bottom ash production rate, and other process parameters.
\n
\n
\n
\n
\n
\n\n
\n
Commodity item, #
\n
Weight fraction, %
\n
Ultimate analysis
\n
Weight fraction, %
\n
\n\n\n
\n
Metals
\n
0.5%
\n
C
\n
51.71%
\n
\n
\n
Biowaste
\n
15%
\n
H
\n
9.25%
\n
\n
\n
Plastics
\n
68%
\n
O
\n
12.41%
\n
\n
\n
Paper and cardboard
\n
10%
\n
N
\n
0.85%
\n
\n
\n
Glass and inerts
\n
2%
\n
Cl
\n
2.42%
\n
\n
\n
Wood
\n
5%
\n
S
\n
0.28%
\n
\n
\n
\n
Moisture
\n
17.06%
\n
\n
\n
Ash
\n
5.56%
\n
\n\n
Table 7.
Waste characterization.
\n
The gasification process is carried out in a plant that is composed of two sections:
Thermal conversion under partial oxidation conditions
Energy recovery (with two options: electricity and heat or only heat)
\n\n
The conversion section is composed of the gasifier itself and the thermal cracking reactor where the tar undergoes cracking and upgrading. The gasifier is fed with the waste once shredded and compacted in order to increase the bulk density at a suitable value to guarantee a constant mechanical feeding. The waste is then converted into syngas by recurring to a thermal cracking at high temperature, sustained by plasma torches, providing a thermal load of 125 kW.
\n
The gasifier temperature as obtained by the energy balance results to be 1350°C in the homogeneous phase. The air-to-waste ratio has been fixed at 2.13 and corresponds to an equivalence ratio of 0.25.
\n
The main input and output parameters are reported in Table 8.
\n
\n
\n
\n
\n\n
\n
Waste flow rate
\n
0.668
\n
Mg/h
\n
\n\n\n
\n
Air flow rate
\n
1425
\n
Nm3/h
\n
\n
\n
Bottom ash
\n
34.15
\n
kg/h
\n
\n
\n
Syngas flow rate (humid)
\n
2059
\n
kg/h
\n
\n
\n
Syngas yield (dry)
\n
1832
\n
Nm3/t
\n
\n
\n
Syngas calorific value (dry)
\n
5.71
\n
MJ/Nm3\n
\n
\n
\n
Engine electricity generated power
\n
832.2
\n
kWe
\n
\n
\n
Cogenerated heat
\n
1058
\n
kWe
\n
\n
\n
Plasma torch absorption
\n
75
\n
kWe
\n
\n
\n
Plasma torch installed power
\n
150
\n
kWe
\n
\n
\n
Cold gas efficiency (CGE)
\n
0.70
\n
—
\n
\n\n
Table 8.
Gasification parameters and calculated data.
\n
\n
\n
\n
\n
4. Conclusions
\n
The integration between the anaerobic digestion plant of biowaste with thermochemical processes such as hydrothermal carbonization coupled with the evaporation/thickening process and gasification of nonbiodegradable waste has been proposed and described.
\n
The mass and energy balances have been reported in order to evaluate the feasibility of the proposed integrated “smart” facility.
\n
The advantages obtained by using the smart facility design can be briefly summarized as follows:
The waste production destined to disposal decreased by 95%.
The leachate to be disposed decreased by more than 66%.
The electricity produced is 5370 MWh/year.
The hydrochar can be sold in the market or used as fuel in the gasifier.
\n\n
By an economic point of view, the capital cost of the smart facility increases by a factor of 3. Anyway, the operating costs strongly decreased by considering the savings connected to the above listed advantages.
\n
The strong reduction of transportation of waste and leachate by trucks, the minimization of air pollution and odor emission, the possibility to cover the electricity cost by self-producing itself without grid losses, the reduction of waste volume of more 95%, and the production of clean biofuel (biomethane) and a high-added value char (hydrochar), all these positive features allow to consider the smart facility and even a green facility.
\n
\n
Acknowledgments
\n
V:ALERE 2019 grant support from Università degli Studi della Campania “L. Vanvitelli” of CHIMERA project is gratefully acknowledged for financial support of the experimental activity.
\n
Bell Production SpA and CEA SpA are acknowledged to have provided the data related to their owned technologies and facilities.
\n
Conflict of interest
The author declares no conflict of interest.
\n',keywords:"anaerobic digestion, biomethane, hydrochar, carbonization, gasification, smart facility, sustainable waste management",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/71962.pdf",chapterXML:"https://mts.intechopen.com/source/xml/71962.xml",downloadPdfUrl:"/chapter/pdf-download/71962",previewPdfUrl:"/chapter/pdf-preview/71962",totalDownloads:564,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 4th 2019",dateReviewed:"March 22nd 2020",datePrePublished:"April 28th 2020",datePublished:"April 28th 2021",dateFinished:"April 28th 2020",readingETA:"0",abstract:"The increase of biowaste generation has reached critical levels in many countries. The European legislation introduced the biowaste treatment and the organic recycling as central theme of its political agenda with the aim to promote the sustainable exploitation of this peculiar waste. The most utilized technologies applied to the biowaste treatment are based on the biological processes targeting to produce biogas or, more recently, biomethane to be used as fuel. The production of biomethane allows to produce a substitute of the fossil methane with a yield of about 0.07gCH4/gbiowaste; the remaining fractions are waste coming from the pretreatment/refining steps, solid digestate or stabilized compost, and leachate. The sustainable treatment of these fractions is a mandatory issue to treat the biowaste in a reliable and sustainable integrated process since their amount is more than 85% and the impact of their treatment on environment and economy of the overall treatment process can be quite relevant. This chapter focused on the so-called smart facility that integrates processes based on thermochemical processes with the biological one targeting to increase the overall sustainability, the flexibility regarding the input biowaste composition, and the independency by the external factors affecting the waste trading.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/71962",risUrl:"/chapter/ris/71962",signatures:"Maria Laura Mastellone",book:{id:"10096",type:"book",title:"Biogas",subtitle:"Recent Advances and Integrated Approaches",fullTitle:"Biogas - Recent Advances and Integrated Approaches",slug:"biogas-recent-advances-and-integrated-approaches",publishedDate:"April 28th 2021",bookSignature:"Abd El-Fatah Abomohra, Mahdy Elsayed, Zuzeng Qin, Hongbing Ji and Zili Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10096.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83962-669-2",printIsbn:"978-1-83962-668-5",pdfIsbn:"978-1-83962-670-8",isAvailableForWebshopOrdering:!0,editors:[{id:"186114",title:"Dr.",name:"Abd El-Fatah",middleName:null,surname:"Abomohra",slug:"abd-el-fatah-abomohra",fullName:"Abd El-Fatah Abomohra"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"314728",title:"Prof.",name:"Maria Laura",middleName:null,surname:"Mastellone",fullName:"Maria Laura Mastellone",slug:"maria-laura-mastellone",email:"marialaura.mastellone@unicampania.it",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Configuration of the base case anaerobic digestion facility",level:"1"},{id:"sec_2_2",title:"2.1 Description of the unit processes",level:"2"},{id:"sec_2_3",title:"2.1.1 Pretreatment and sorting",level:"3"},{id:"sec_3_3",title:"2.1.2 Anaerobic digestion",level:"3"},{id:"sec_4_3",title:"2.1.3 Cogeneration",level:"3"},{id:"sec_5_3",title:"2.1.4 Leachate storage tank",level:"3"},{id:"sec_6_3",title:"2.1.5 Composting",level:"3"},{id:"sec_8_2",title:"2.2 The critical issues of the present configuration",level:"2"},{id:"sec_10",title:"3. Configuration of the integrated anaerobic digestion facility",level:"1"},{id:"sec_10_2",title:"3.1 Description of the unit processes of the alternative configuration",level:"2"},{id:"sec_10_3",title:"Table 2.",level:"3"},{id:"sec_11_3",title:"Table 3.",level:"3"},{id:"sec_12_3",title:"3.1.3 Evaporator",level:"3"},{id:"sec_13_3",title:"3.1.4 Dewatering and drying",level:"3"},{id:"sec_14_3",title:"3.1.5 Gasification",level:"3"},{id:"sec_15_3",title:"3.1.6 Energy production",level:"3"},{id:"sec_17_2",title:"3.2 Assessment of the unit processes of the alternative configuration",level:"2"},{id:"sec_17_3",title:"Table 4.",level:"3"},{id:"sec_18_3",title:"Table 7.",level:"3"},{id:"sec_21",title:"4. Conclusions",level:"1"},{id:"sec_22",title:"Acknowledgments",level:"1"},{id:"sec_25",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'\nEuropean Commission. Communication from the Commission to the Council and the European Parliament on Future Steps in Bio-Waste Management in the European Union, COM/2010/0235; 2010\n'},{id:"B2",body:'\nZaccariello L, Cremiato R, Mastellone ML. Evaluation of municipal solid waste management performance by material flow analysis: Theoretical approach and case study. Waste Management and Research. 2015;33(10):871-885\n'},{id:"B3",body:'\nSchüch A, Morscheck G, A. Lemke MN. Bio-waste recycling in Germany – Further challenges. Procedia Environmental Sciences. 2016;35:308-318\n'},{id:"B4",body:'\nDahlén L, Vukicevic S, J.E. Meijer AL. Comparison of different collection systems for sorted household waste in Sweden. Waste Management. 2007;27:1298-1305\n'},{id:"B5",body:'\nCEA. Economic Data Related a Full-Scale Anaerobic-Aerobic Digestion Plant [Internet]. 2020. Available from: www.cea.na.it\n\n'},{id:"B6",body:'\nIUPAC. Compendium of Chemical Terminology Gold Book; 2014. DOI: 10.1351/goldbook. ISBN: 0-9678550-9-8\n'},{id:"B7",body:'\nFagbemi L, Khezami L, Capart R. Pyrolysis products from different biomasses. Applied Energy [Internet]. 2001;69(4):293-306 Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306261901000137\n\n'},{id:"B8",body:'\nUnited States Department of Agriculture. Glossary of Agricultural Terms. 2014. Available from: https://agclass.nal.usda.gov/agt.shtml\n'},{id:"B9",body:'\nLehmann J, Joseph S. Biochar for environmental management - an introduction. In: Biochar for Environmental Management: Science and Technology. London: Earthscan; 2009. pp. 1-12\n'},{id:"B10",body:'\nLibra JA, Ro KS, Kammann C, Funke A, Berge ND, Neubauer Y, et al. Hydrothermal carbonization of biomass residuals: A comparative review of the chemistry, processes and applications of wet and dry pyrolysis. Biofuels [Internet]. 2011;2(1):71-106. Available from: https://www.tandfonline.com/doi/full/10.4155/bfs.10.81\n\n'},{id:"B11",body:'\nMumme J, Eckervogt L, Pielert J, Diakité M, Rupp F, Kern J. Hydrothermal carbonization of anaerobically digested maize silage. Bioresource Technology [Internet]. 2011;102(19):9255-9260 Available from: https://linkinghub.elsevier.com/retrieve/pii/S0960852411009266\n\n'},{id:"B12",body:'\nMastellone ML. Technical description and performance evaluation of different packaging plastic waste management’s systems in a circular economy perspective. Science of the Total Environment [Internet]. 2020;718:137233 Available from: https://linkinghub.elsevier.com/retrieve/pii/S0048969720307439\n\n'},{id:"B13",body:'\nMastellone ML. Waste management and clean energy production from municipal solid waste. New York: Nova Publishers; 2015. ISBN: 978-1-63463-827-2\n'},{id:"B14",body:'\nFernández-González JM, Grindlay AL, Serrano-Bernardo F, Rodríguez-Rojas MI, Zamorano M. Economic and environmental review of waste-to-energy systems for municipal solid waste management in medium and small municipalities. Waste Management [Internet]. 2017;67:360-374 Available from: http://www.sciencedirect.com/science/article/pii/S0956053X17303057\n\n'},{id:"B15",body:'\nLopez G, Artetxe M, Amutio M, Alvarez J, Bilbao J, Olazar M. Recent advances in the gasification of waste plastics. A critical overview. Renewable and Sustainable Energy Reviews [Internet]. 2018;82:576-596. Available from: http://www.sciencedirect.com/science/article/pii/S1364032117312832\n\n'},{id:"B16",body:'\nBanks CJ, Chesshire M, Heaven S, Arnold R. Anaerobic digestion of source-segregated domestic food waste: Performance assessment by mass and energy balance. Bioresource Technology [Internet]. 2011;102(2):612-620 Available from: https://linkinghub.elsevier.com/retrieve/pii/S0960852410013404\n\n'},{id:"B17",body:'\nMøller J, Christensen TH, Jansen J, La C. Anaerobic digestion: Mass balances and products. In: Solid Waste Technology & Management [Internet]. Chichester, UK: John Wiley & Sons, Ltd; 2010. pp. 618-627. Available from: http://doi.wiley.com/10.1002/9780470666883.ch39\n\n'},{id:"B18",body:'\nNallathambi GV. Anaerobic digestion of biomass for methane production: A review. Biomass and Bioenergy [Internet]. 1997 Jan;13(1–2):83-114 Available from: https://linkinghub.elsevier.com/retrieve/pii/S0961953497000202\n\n'},{id:"B19",body:'\nGSE. Economic Incentives for Biogas Electricity Production. 2020. Available from: www.gse.it\n'},{id:"B20",body:'\nISPRA. Waste Report (Rapporto Rifiuti). 2019. Available from: http://www.isprambiente.gov.it/it\n'},{id:"B21",body:'\nMastellone ML. Private Communication. 2020\n'},{id:"B22",body:'\nFunke A, Ziegler F. Hydrothermal carbonization of biomass: A summary and discussion of chemical mechanisms for process engineering. Biofuels, Bioproducts and Biorefining [Internet]. 2010;4(2):160-177. Available from: http://doi.wiley.com/10.1002/bbb.198\n\n'},{id:"B23",body:'\nHu B, Wang K. WL et al. engineering carbon materials from the hydrothermal carbonization process of biomass. Advanced Materials. 2010;22(7):813-828\n'},{id:"B24",body:'\nLibra JA. Hydrothermal carbonization of biomass residuals: A comparative review of the chemistry, processes and applications of wet and dry pyrolysis. Biofuels. 2011;2(1):89-124\n'},{id:"B25",body:'\nPeterson AA, Vogel F, Lachance RP, Froeling M, Antal MJ. Thermochemical biofuel production in hydrothermal media: A review of sub- and supercritical water technologies. Energy and Envinronmental Sciences. 2008;1:32-65\n'},{id:"B26",body:'\nSharma R, Jasrotia K, Singh N, Ghosh P, Srivastava S, Sharma NR, et al. A comprehensive review on hydrothermal carbonization of biomass and its applications. Chemistry Africa [Internet]. 2020;3(1):1-19 Available from: http://link.springer.com/10.1007/s42250-019-00098-3\n\n'},{id:"B27",body:'\nArena U, Zaccariello L, Mastellone ML. Gasification of a plastic waste in a fluidized bed of olivine. In: CFB 2008—Proceedings of the 9th International Conference on Circulating Fluidized Beds, in Conjunction with the 4th International VGB Workshop “Operating Experience with Fluidized Bed Firing Systems.” 2008\n'},{id:"B28",body:'\nHatayama A. Gasification of waste plastics by steam reforming in a fluidized bed. Journal of Material Cycles and Waste Management. 2009;11:144\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Maria Laura Mastellone",address:"marialaura.mastellone@unicampania.it",affiliation:'
University “Luigi Vanvitelli,” DiSTABiF, Caserta, Italy
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Nigeria’s cattle population is estimated to be around 18.4 million. The number is far insufficient to meet the country’s demand for meat, milk, and other cow products, let alone contribute to GDP. N’dama and Muturu are both Nigerian breeds that are resistant to trypanosomosis. They are humpless longhorn and humpless shorthorn types of beef cattle. The dairy and beef cow industries’ inadequate adoption of ART is partly to blame for Nigeria’s low cattle output. Sex determination, multiple-ovulation and embryo transfer (MOET), oestrus synchronization, artificial insemination (AI), in vitro fertilization (IVF), cloning, and genetic engineering are all examples of assisted reproductive technologies. It has been reported in humans, rodents and domestic animals, abnormal fetuses, newborns and adult offspring arise from ART. Improper matching of breeding animals mostly leads to overfat calves. This review centers on the applications and potentials of ART in the production of trypanotolerant N’dama and Muturu cattle breeds. 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In the following chapter, we will cover a few aspects of value-based healthcare, its reimbursement model, the integrated practice units, and the information technology necessary to implement it.",book:{id:"9566",slug:"bioethics-in-medicine-and-society",title:"Bioethics in Medicine and Society",fullTitle:"Bioethics in Medicine and Society"},signatures:"Patrick Rech Ramos",authors:[{id:"321359",title:"Dr.",name:"Patrick",middleName:"Rech",surname:"Rech Ramos",slug:"patrick-rech-ramos",fullName:"Patrick Rech Ramos"}]}],onlineFirstChaptersFilter:{topicId:"167",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. 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Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{}},subseries:{item:{id:"40",type:"subseries",title:"Ecosystems and Biodiversity",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation",scope:"
\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
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