Year 2019.
\r\n\tThe WHO classification in 2007; was based on the histogenesis and cell origin of the tumor. In the latest classification made in 2016; to better characterize the tumor and obtain better data on its prognosis; The combination of molecular and genetic biomarkers and histopathological features of the tumor was used. Despite all current treatment approaches, the median survival time is around 12 months in most GBM patients. Compared with the situation of some types of successfully treated cancers; the survival time of GBM patients is not at an acceptable level today. In the treatment of CNS tumors; surgery, chemotherapy, and radiation treatments (x-rays, gamma rays, electron and proton beams) are used. The therapeutic potential of chemotherapy; New strategies are needed to increase drug concentration at the diseased site, as this largely depends on the ability of the chemotherapeutic agent to achieve effective concentrations at tumor localization. Based on our better understanding of the genetic and molecular characteristics of CNS tumors; Targeted therapies, including vaccines, and treatment protocols such as immunotherapy are promising developments.
\r\n\r\n\tThis book supposes to be written by many authors who have an internationally honored place in their field to share their ideas about the treatment of CNS tumors. Surgery, Radiotherapy, Chemotherapy and Antiangiogenic Therapy Protocols, Immunotherapy, Molecular Therapy, Specific target-agents therapy with Nanoparticles and Gene Therapy for CNS tumors among the book chapters.
\r\n\tIn these sections; there are many practical pieces of information that can help the students who graduated from the Medicine Faculty and specialist doctors who are interested in Neurosurgery.
Foreign direct investments (FDIs) are defined as transfer of capital from one country to other where the investor has control or a significant degree of influence on the management of a business located in the host country [1].
Foreign Direct Divestment (FDD) are defined as an adjustment in the ownership of a business that involves the partial or full disposal of an asset or a business unit [2].
The theory of economic development shows that capital is one essential piece of Gross Domestic Product (GDP) growth. The reasoning is that more FDI helps in GDP growth whereas more FDD affects the GDP growth [3].
To understand the dynamic of the FDI process and the FDD process it seems external factors play an essential role on determining the decision to invest or the decision to divest.
The literature defines business or investment climate multifold. In general, usage of the term falls into three major categories: (1) an overall measure of growth or business health in a region; (2) a set of factors believed to contribute to regional economic growth; and (3) an intangible asset in the form of a regional reputation for business friendliness and receptiveness to growth [4].
In that continuum, efficient regulations, transparency, rule of law, strong institutions, low operating costs and predictability, inter alia, are all elements that can enhance the appeal to foreign investors. That premise assumes that previous conditions need to be in place: business opportunities and a positive cost/benefit equation. However, the opposite seems to be true: poor business climates where the rule of law is weak, corruption is pervasive, costs of doing business are high and unpredictable and transparency and predictability are absent appear to deter an investment decision.
This chapter is about the business climate as a relevant factor that drives FDD. Overall the methodology followed is this: review of indicators of business climate factors. Similarly, the FDI rankings are reviewed. It is sought to find a pattern between weak indicators of business climate factors and low flow of FDI. For that purpose, some countries’ rankings on doing business, corruption perception index, and rule of law index are reviewed.
The second section highlights the factors that trigger FDI. By looking at the relevant data, it is intended to stress that a better business climate ranking contributes to boost FDI flows.
The third section shows the opposite: a weak business climate fosters FDD. A country will have a weak business climate when it is ranked in the lowest range on Doing Business, Corruption Perception Index and the Rule of Law Index.
The fourth section highlights the externalities of FDD. Just as FDI is considered to bring about externalities such as job creation and productivity enhancement, a connection between FDD and loss of jobs and GDP shrinking is explored.
The fifth section makes some suggestions to mitigate the impact of FDD externalities. As this essay is written during the COVID-19 pandemic it is assumed that FDD negative externalities will be more significant globally and hence global remedies might be needed.
The sixth section contains the conclusions. Combining the analysis of the data with some empirical observations certain conclusions are reached as regards to the connection of business climate and FDD as well as to some suggestions to mitigate the FDD externalities.
The seventh section contains the references.
Foreign direct investments (FDIs) have been considered an important tool for economic development [5].
FDIs bring about not only capital and jobs to the host countries but also enhance the economic apparatus directly and indirectly in areas such as innovation, cultural trends and even language use [6].
FDIs can be considered the historic equivalent of territory conquests. Like that possibly overextended analogy, the rationale behind the conquests are multifold. In the case of FDIs, the reason for expanding overseas can be strategic or tactical going from market reach, factory allocation, costs reduction, profit enhancement, trend following, merger, competitors chase, trademark protection, etc.
From an economic efficiency standpoint FDIs should be assumed to be conducted when the benefits exceed the costs. That does not occur all the times as some of the benefits of FDIs can differ depending on the rationale behind. In a complicated world and with FDI actors as varied as they area and with interests as varied as they could be, the benefits could be difficult to measure. For example, State owned investors could have geopolitical interests in an investment. Hence, measuring the FDI benefit merely by the existence of profit could yield a wrong conclusion.
Thus, the factors that trigger FDIs are inexorably connected to the subjacent interests. However, the data that is available measures the FDI that is homogeneous, meaning FDIs where the interests are primarily economic and where the efficiency tends to be of the essence, i.e., costs do not exceed the benefits.
In that continuum FDI flow is linked to a positive business climate. That is, there is a correlation between a good business climate and high levels of FDI.
An analysis of a business climate combines factors extrinsic to the business that impact the success or failure of the operation. Factors such as costs and time of doing business, including permits to operate or hire, physical and human infrastructure, corruption, rule of law, governance and political stability are all part of the overall analysis of the framework of a business climate.
Countries tend to attract more FDIs when it is easier, cheaper and faster to do business, when corruption is low and when the rule of law is prevalent. Table 1 about ranking of FDI inflow recipients show the rankings of selected countries in relevant factors of business climate. It shows that the top 5 FDI inflow recipients perform above average in some business climate factors’ rankings.
Ranking of FDI recipients v. ranking in business climate factors | ||||
---|---|---|---|---|
Country | FDI inflow ranking | Doing business ranking Total: 190 | Corruption perception index/ranking Total: 180 | Rule of law index ranking Total: 128 |
The USA | 1 | 6 | 23 | 21 |
China | 2 | 31/ 3 (Hong Kong) | 80/16(Hong Kong) | 88/16 (Hong Kong) |
Singapore | 3 | 2 | 4 | 12 |
The Netherlands | 4 | 42 | 8 | 5 |
The United Kingdom | 5 | 8 | 12 | 13 |
A case of point is Jordan. It has been implementing significant changes to ease doing business in areas such as getting credit, paying taxes and resolving insolvencies. The Doing Business indicators, scores and rankings, have been improving in consecutive years. Inflow FDIs have increased from $1600 million to $2030 million in 3 years up to year 2017. Jordan improved its Doing Business ranking in more than 10% in 3 years (UNCTAD World Investment Report and Doing Business).
Of course, correlation makes sense when the world economy is growing, and GDP is not contracted, when there is no world economic recession and when the economic resources of the country are not limited.
In circumstances of economic expansion there seems to be a correlation between weak business climates and low FDIs.
The empirical evidence shows that in the absence of strong business climate the host countries are more prone to attract less FDI.
For example, when the rule of law is weak FDI inflow tends to be low. Table 2 about the rule of law index rankings and FDI inflows shows the amount of FDI attracted by countries ranked at the bottom on rule of law.
Country | Rule of law index ranking | FDI inflow amount (in millions of US dollars) |
---|---|---|
Congo, D.R. | 124 | 1494 |
Afghanistan | 123 | 139 |
Mauritania | 122 | 71 |
When transparency is low, FDI tends to be low. Table 3 about the corruption perception index rankings and FDI inflows shows the amount of FDI attracted by countries ranked at the bottom on corruption.
Country | Corruption perception index ranking | FDI inflow amount (in millions of US dollars) |
---|---|---|
Somalia | 180 | 409 |
South Sudan | 179 | n/a |
Syria | 178 | n/a |
Yemen | 177 | −282 |
When economic freedom is restricted, FDI tends to be low. Table 4 about the economic freedom index rankings and FDI inflows shows the amount of FDI attracted by countries ranked at the bottom on economic freedom.
Country | Economic freedom index ranking | FDI inflow amount (in millions of US dollars) |
---|---|---|
North Korea | 180 | N/A |
Cuba | 178 | 2134 |
Eritrea | 177 | 61 |
When doing business is difficult, FDI tends to be low. Table 5 about the ease of doing business rankings and FDI inflows shows the amount of FDI attracted by countries ranked at the bottom on ease to do business.
FDIs are poverty alleviation weapons. The benefits of FDIs have been consensually accepted to be vast and broad. The range goes from job creation, cluster creation, education enhancement, food improvement, infrastructure development, tourism recognition, technology transfer and commerce catalyst up to political stability and social peace.
FDI can also fill, first, the “investment gap” by providing the much-needed capital for domestic investment; secondly, the “foreign exchange gap” by providing foreign currency through initial investments and subsequent export earnings; and finally, the “tax revenue gap” by generating tax revenues through creation of additional economic activities [12].
The contrary is also true. FDIs are defined by control of a foreign entity of a business operation beyond the borders of origin. That control usually takes the form of ownership but it is not an exclusive trait to fulfill the goal. When control of the foreign operation ceases totally or partially by change, reduction or suppression of the activity or ownership a foreign direct divestment (FDD) can be deemed to have occurred [13].
FDD can be motivated by internal reasons. Those internal reasons can be intrinsic to the whole business undertaking or internal to the local operation. They include tactical ones, such as geographic location advantage or disadvantage, financial maneuvering, business structure, or limited resources as well as strategic ones such as market reach, competitors challenge, and product development [14].
FDDs can also be motivated by external reasons. A weak business climate where rules are not respected and predictable and where doing business is not efficient might the strongest determinant to FDD (Figure 1).
The role of host country investment climate factors. Source: Borga et al. [
Thus, excessive corruption which makes costs, times and procedure outcomes unpredictable can be a deterrent of FDI. However, the evidence shows that efficiency, i.e., less costs, more benefits, is the determinant external factor of FDI. The opposite, absence of efficiency, i.e., more costs, less benefits, could be a determinant factor of FDD. Hence, a correlation between difficulty of doing business and low FDI is prevalent.
A relevant example on this point is Angola. Angola has worsened its ranking and scores in the Doing Business indicators. Two of the indicators, enforcing contracts and obtaining credit have worsened during the period lapsing from the year 2015. During that period the FDI inflow have gone from $10,028 million to $ − 5732 million in 2018 (UNCTAD World Investment Report, Doing Business).
With FDD the host countries can suffer significantly in economic, social, and political terms. A fleeing capital that has been significant in terms of GDP and that is not substituted with other capital makes locals lose jobs, makes local small businesses vanish, and brings about losses in fiscal income, among other consequences. More significantly, the impact in the host country can also have social repercussions such as riots, violence and unrest as well as political instability.
Countries with low FDI are usually exporters of migrants. Table 6 about FDI inflows and number of refugees shows the amount of FDI attracted by countries with most outgoing refugees.
Country | FDI inflow amount (in millions of US dollars) | Refugees |
---|---|---|
Syria | N/A | 5.6 million |
Afghanistan | 139 | 2.7 million |
South Sudan | N/A | 2.3 million |
Myanmar | 3554 | 1.1 million |
With lack of incentives to prosper economically countries with low FDI are also more unlikely to adopt environmental friendly policies. Table 7 about FDI inflows and environmental performance index shows the amount of FDI attracted by countries with poor environmental performance.
Country | FDI inflow amount (in millions of US dollars) | Environmental performance index |
---|---|---|
Burundi | 1 | 180 |
Bangladesh | 3613 | 179 |
Congo, D.R. | 1494 | 178 |
Home countries are not necessarily the beneficiaries of FDD. The capital that flew away from a host country can go to another one. It might not be significant to impact in the GDP of the home country, nor to create more jobs, enhance the home country productivity or to gross up the home country’s treasury. However, the global impact of massive FDDs can worsen the inequality, flows of refugees and global warming.
FDIs pursue many purposes, one of which is profit seeking. Investors might still achieve that goal after a FDD has taken place and host countries might not necessarily face all the negative externalities of FDDs if certain global policies are implemented.
Setting up a global Environment Social and Governance Fund (ESGF) through a multilateral entity could mitigate the negative externalities of FDDs. The ESGF could endow with private capital, such as proceeds from FDD and/or open to all types of capital. The capital that is not invested in FDIs could still be beneficial to developing countries. Investors in search of profits could be benefitted, albeit without controlling the investment in a modality much more similar to portfolio investments.
The ESGF will make impact investments in different types of international business opportunities that are environmentally friendly, socially beneficial, and well governed. Home countries could play a role suggesting or encouraging owners of the FDD returning capital to devote a portion of the capital to the ESGF perhaps under certain tax arrangements, such as tax benefits to be granted to investors who devote capital to the ESGF.
The ESGF in turn could grant money to countries falling under certain economic category provided they fulfill certain objectives in environmental, social and governance policies. For example, if a country can increase its ranking in the rule of law index more than 10% every year for 2 years, the country can be entitled to participate in requests for grants from the ESGF. The grants will be disbursed on condition of maintaining certain conditions and developing programs devoted to mitigating the externalities of FDDs.
The global economic, social and political consequences of the COVID-19 pandemic are still to be seen. It might easily happen that FDDs will occur not as a consequence of weak business climates but because of a global economic recession, lack of demand, or irrelevance of supplies. The same externalities of FDDs could be suffered by most countries.
Universal Basic Income (UBI) has been widely recommended as a measure to alleviate the needs of the poor. UBI has received recent publicity as a possible remedy to alleviate the needs of many during the pandemic crisis. The rationale behind the UBI is that people under certain conditions will receive a fixed amount of money. Once spent the UBI is evaporated and there is no legal right to it. Bluntly, it is a donation by the government.
A complementary concept might be useful: Sovereign Wealth Funds (SWF) with a more ambitious twist. SWFs are investment funds created and commonly owned by sovereign States to maximize the profits of their wealth usually but not necessarily yielding from commodities. Currently, there are more than 90 SWFs holding more $8 trillion [18].
SWFs have been highly profitable. For example, the Norway Government Pension Fund Global is the largest SWF, created in 1990 and currently holding more than $1 trillion. It has generated an average annual return of 6% since 1998 [19].
Many SWFs have been created mainly for purposes different than direct social benefits to the citizens of the owner States, such as macroeconomic policies [20]. However, in general, people receive proceeds from SWFs investments directly or indirectly, even in seemingly citizens’ remote circumstances as managing the balance of payments [21].
The Alaska Permanent Fund is an example of a SWF where there is a direct benefit to the citizens as returns are distributed through a citizens’ dividend program under certain conditions. It was established in the Alaska Constitution in 1976 and managed by a state-owned corporation, the Alaska Permanent Fund Corporation (APFC). It is endowed from the proceeds of oil. It distributes its returns through a citizens’ dividend program. The fund currently holds over $66 billion in assets. It has paid up to $2072 in dividends.
The negative externalities of FDDs will be more prevalent in the aftermath of the COVID-19 crisis. The impact of the global recession and reduction of the demand is likely to be reflected in massive FDD. Developing countries will suffer significantly economically and socially at a minimum. The chaos of many developing countries struggling with basic needs can in turn deteriorate the business climates to further affect the flow of FDD.
Thus, inspired by the SWF, a Universal Wealth Fund (UWF or 3UF) could be established through multilateral arrangements. It could be set up to mitigate not only the effects of a surge of FDD but also the global economic and social damage post COVID-19.
The 3UF could be endowed by countries, by corporations and by NGOs. The corporations could make their contributions directly from the capital of the FDD or as some kind of tax planning tool or even as some kind of fine or penalty mitigation when they are punished or fined by multilateral entities such as the European Union.
Proceeds could be distributed directly to countries under condition that they are either invested in social projects and/or turn to the citizens in form of dividends which could be structured in terms of legal rights to which they are entitled. As opposed to UBI which are discretionary, rights to 3UF dividends can benefit large scale capitalization, financial literacy, and governance of the 3UF.
Be it as it may, the disadvantages of FDD to host developing countries could be mitigated. It was important before; it is more important in the world after the COVID-19 crisis.
FDIs are important tools for economic development. FDIs entail capital transfer to host countries which sometimes starve of funding to provide for the wellbeing of their citizens. Through FDIs many developing countries can ameliorate the impact of the poverty in the social and economic realms. Jobs are created, local business emerge, more public revenues can be collected, physical infrastructure is enhanced, human infrastructure is benefited, and the host country’s branding can emerge as a favorable place to invest, among others.
The FDI process is complex as is the decision to invest. Many factors play a determinant role in FDIs. Internal and external factors of different nature can push the capital inside or outside the host country. Among the external factors, business climate plays a crucial role. The combination of external factors that is commonly known as business climate relates to all the host country’s conditions that make the business easy to operate, diminish the costs and sets up in advance the rules under which the business will function. Unpredictability of rules, costs, and processes are usually contrary to FDIs. However, even in conditions of difficult, expensive, and lengthy conditions to do business, corruption, and weak rule of law, FDIs flow, albeit somehow diminished.
Countries that receive the most FDIs are ranked above average in the Doing Business indicator, Corruption Perception index and Rule of Law index. On the contrary the countries that are badly ranked in those indexes have attracted a lower amount of FDI.
The empirical evidence shows that in the absence of strong business climate the host countries are more prone to attract less FDI. That is the case with the Doing Business indicator, the Corruption Perception indicator, and the Rule of Law indicator.
It can be concluded that excessive corruption which makes costs, times, and procedure outcomes unpredictable can be a deterrent of FDI. However, the evidence shows that efficiency, i.e., less costs, more benefits, is the determinant external factor of FDI. The opposite, low efficiency, could be a determinant factor of FDD.
The correlation between weak business climates and FDD is noticeable although not determinant. As FDD decisions are dependent on internal factors of the investor as well, a conclusion on a direct relation between weak business climates and FDD cannot be reached. However, the evidence shows that absence of efficiency, i.e., more costs, less benefits, could be a determinant factor of FDD.
The impact of FDD is somehow the reverse of the benefits of FDI for the host countries. FDDs can also bring about negative externalities to the home countries under the form of migrants and deteriorated environment.
At a global level, investment funds can play a role to mitigate the impact of FDDs. A multilateral fund devoted to environmental and social projects properly governed can be established in a way that appeals the outflow capital resulting from the FDD. The profits could in turn be offered to countries that satisfy certain requirements and conditioned to be invested in projects devoted to reducing poverty or other FDD negative externalities. Similarly, an unprecedented universal Sovereign Wealth Fund could also mitigate the negative impact of massive capital mobilization from poor counties. In the seemingly critical times that will follow the COVID-19 pandemic, global policy makers need to be creative in large scale to long term sustainable solutions for all.
The author has avoided listing some countries in the rankings due to professional conflicts of interests.
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Evans",authors:[{id:"96409",title:"Prof.",name:"Carla",middleName:null,surname:"Evans",slug:"carla-evans",fullName:"Carla Evans"},{id:"96472",title:"Prof.",name:"Budi",middleName:null,surname:"Kusnoto",slug:"budi-kusnoto",fullName:"Budi Kusnoto"},{id:"172854",title:"Dr.",name:"Emilia Taneva",middleName:null,surname:"Taneva",slug:"emilia-taneva-taneva",fullName:"Emilia Taneva Taneva"}]},{id:"18426",doi:"10.5772/18746",title:"Factors Affecting the Success of Dental Implants",slug:"factors-affecting-the-success-of-dental-implants",totalDownloads:17504,totalCrossrefCites:9,totalDimensionsCites:36,abstract:null,book:{id:"179",slug:"implant-dentistry-a-rapidly-evolving-practice",title:"Implant Dentistry",fullTitle:"Implant Dentistry - A Rapidly Evolving Practice"},signatures:"Carlos Nelson Elias",authors:[{id:"32438",title:"Prof.",name:"Carlos",middleName:null,surname:"Elias",slug:"carlos-elias",fullName:"Carlos Elias"}]},{id:"32161",doi:"10.5772/38059",title:"Caries Through Time: An Anthropological Overview",slug:"caries-archaeological-and-historical-record",totalDownloads:6550,totalCrossrefCites:4,totalDimensionsCites:33,abstract:null,book:{id:"1742",slug:"contemporary-approach-to-dental-caries",title:"Contemporary Approach to Dental Caries",fullTitle:"Contemporary Approach to Dental Caries"},signatures:"Luis Pezo Lanfranco and Sabine Eggers",authors:[{id:"115399",title:"Dr.",name:"Luis",middleName:null,surname:"Pezo-Lanfranco",slug:"luis-pezo-lanfranco",fullName:"Luis Pezo-Lanfranco"}]}],mostDownloadedChaptersLast30Days:[{id:"61046",title:"Optical Diagnostics to Improve Periodontal Diagnosis and Treatment",slug:"optical-diagnostics-to-improve-periodontal-diagnosis-and-treatment",totalDownloads:7339,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The performance of clinicians undertaking periodontal assessment or periodontal therapy can be improved by using optical methods as adjuncts to visual inspection and periodontal probing. Subtle changes that occur over time in periodontal tissues that are below the detection limit of visual examination or periodontal probing can be found and tracked accurately over time using 3D imaging, fluorescence spectroscopy, and optical coherence tomography. During debridement of teeth and dental implants, the effective removal of subgingival microbial biofilms and dental calculus deposits can be enhanced using magnifying loupes and operating microscopes and by novel methods based on the interactions of light with bacterial deposits, such as differential reflectometry and light-induced fluorescence. While such techniques can also be used using initial case assessment, their primary purpose is for checking debridement procedures, since the point when bacterial deposits are no longer present represents an endpoint for treatment. The concept of real-time feedback has been developed, using fluorescence readings to control the removal of deposits. Overall, optical methods can support traditional periodontal diagnosis and improve treatment planning and clinical periodontal care.",book:{id:"7244",slug:"periodontology-and-dental-implantology",title:"Periodontology and Dental Implantology",fullTitle:"Periodontology and Dental Implantology"},signatures:"Fardad Shakibaie and Laurence Walsh",authors:[{id:"179467",title:"Prof.",name:"Laurence",middleName:null,surname:"Walsh",slug:"laurence-walsh",fullName:"Laurence Walsh"},{id:"235443",title:"Dr.",name:"Fardad",middleName:null,surname:"Shakibaie",slug:"fardad-shakibaie",fullName:"Fardad Shakibaie"}]},{id:"24363",title:"Biomechanics of Tooth-Movement: Current Look at Orthodontic Fundamental",slug:"biomechanics-of-tooth-movement-current-look-at-orthodontic-fundamental",totalDownloads:26816,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"277",slug:"principles-in-contemporary-orthodontics",title:"Principles in Contemporary Orthodontics",fullTitle:"Principles in Contemporary Orthodontics"},signatures:"Joanna Antoszewska and Nazan Küçükkeles",authors:[{id:"50158",title:"Prof.",name:"Joanna",middleName:null,surname:"Antoszewska",slug:"joanna-antoszewska",fullName:"Joanna Antoszewska"}]},{id:"71271",title:"Flap Techniques in Dentoalveolar Surgery",slug:"flap-techniques-in-dentoalveolar-surgery",totalDownloads:2628,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Most dentoalveolar procedures involve the reflection of mucosal flaps. This step is crucial for exposure or removal of impacted teeth, implant bed preparation, exposure of the alveolar bone for augmentation, periodontal surgeries, and repair of mucosal soft tissue defects, such as oroantral fistula. Because of the rich vascularity of the oral mucosa, great freedom is allowed for flap design, but it tends to result in carelessness and lack of thoughtful planning, which may lead to uneventful outcomes or/and complications. In this chapter, we review oral anatomy, classification, indications, and complications of common oral flap techniques; common flap designs are illustrated, and their fundamental principles are highlighted. The review has covered various flap designs based on their indications. Yet the common flap’s principles are fundamental for all types of flaps regardless of their application, namely, it should provide wide exposure, clear vision, good access, and assure rich vascularity and good final aesthetic outcome.",book:{id:"9387",slug:"oral-diseases",title:"Oral Diseases",fullTitle:"Oral Diseases"},signatures:"Randa Abdulmoein AlFotawi",authors:[{id:"308701",title:"Dr.",name:"Randa",middleName:"Abdulmoein",surname:"Alfotawi",slug:"randa-alfotawi",fullName:"Randa Alfotawi"}]},{id:"65088",title:"Evaluation and Management of Mandibular Fracture",slug:"evaluation-and-management-of-mandibular-fracture",totalDownloads:2903,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The mandibular bone is an important component of the facial bone, which has a unique role in digestive system, speech, and facial esthetics. For these important functions of mandibular bone, it is vital that surgeons should not only treat function but also consider the esthetics together. Mandibular fractures are among the most common traumatic injuries of the maxillofacial region. Even though treatment modalities are well established and being practiced for a long time, untreated and postoperative complications still decrease the patient’s quality of life. This chapter aims to describe the cause, clinical presentations, diagnoses, and current treatment methods on the basis of resent literature.",book:{id:"7572",slug:"trauma-in-dentistry",title:"Trauma in Dentistry",fullTitle:"Trauma in Dentistry"},signatures:"Guhan Dergin, Yusuf Emes and Buket Aybar",authors:[{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin"},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes"},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar"}]},{id:"56461",title:"Permanent Maxillary and Mandibular Incisors",slug:"permanent-maxillary-and-mandibular-incisors",totalDownloads:2715,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The permanent incisors are the front teeth that erupt between 6 and 8 years of age. They are eight in number, four upper and four lower, two centrals and two laterals. They have sharp biting surfaces designed for shearing and cutting of food materials into small chewable pieces. They are the teeth most visible to the others during eating, smiling and talking, and thus, they have high aesthetic value for the individuals. The unique characteristics, arch position, function, development and chronological age of each tooth will be highlighted. In addition, the different aspects with their geometric outlines, outlines and surface anatomy of these teeth will be described. A brief explanation about the pulp cavity, tooth socket and normal occlusion for each tooth will be included.",book:{id:"5814",slug:"dental-anatomy",title:"Dental Anatomy",fullTitle:"Dental Anatomy"},signatures:"Mohammed E. Grawish, Lamyaa M. Grawish and Hala M. Grawish",authors:[{id:"82989",title:"Prof.",name:"Mohammed",middleName:"E",surname:"Grawish",slug:"mohammed-grawish",fullName:"Mohammed Grawish"}]}],onlineFirstChaptersFilter:{topicId:"174",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"80964",title:"Upper Airway Expansion in Disabled Children",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:43,totalDimensionsCites:0,doi:"10.5772/intechopen.102830",abstract:"Breathing is essential for life in all of its stages. Cellular, mitochondrial respiration requires an adequate supply of oxygen, provided by the air we breathe, after airway conduction, treatment by the lungs, and transport to tissues. At different stages of life, pediatric dentists and orthodontists can intervene in the upper airway, expanding it, which helps with ventilation. The greater airway space, if used, contributes in different ways to the child’s development and the recovery of respiratory problems and should always be present as a weapon that physicians and the population should know. The value of the techniques becomes even more important when applied to children and young people with disabilities who can significantly improve their development and performance. Rapid Maxillary Expansion and Extraoral Traction Appliances are two important pediatric resources to treat these children. Clinical practice of the authors, is discussed, emphasizing the importance of early intervention and the need for multi and interdisciplinary collaboration in the follow-up of disabled people.",book:{id:"10827",title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg"},signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman"},{id:"80963",title:"Pain Perception in Patients Treated with Ligating/Self-Ligating Brackets versus Patients Treated with Aligners",slug:"pain-perception-in-patients-treated-with-ligating-self-ligating-brackets-versus-patients-treated-wit",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.102796",abstract:"This study compared the perception of pain experienced by patients undergoing orthodontic treatment with conventional, self-ligating brackets and aligners, and investigated the impact that pain had on their daily lives. 346 consecutive patients were included in the study: 115 patients treated with conventional brackets, 112 Patients treated with self-ligating brackets, and 119 patients treated with aligners. The quantitative aspect of pain was assessed using the Visual Analogue Scale, while the qualitative aspect of pain was evaluated using the Moroccan Short Form of McGILL Pain questionnaire. In all three groups experienced pain after activation tended to decrease in the following week. This pain was greater in patients with conventional braces and less in patients with aligners. Using the M-SF-MPQ to describe the qualitative aspect of the pain revealed that the “cramping مزير,” “aching تيألم ” aspect was most accentuated in the 3 groups. Medication intake was correlated with the intensity of pain experienced in all 3 systems. As for the impact of pain on daily activities, patients in groups of conventional and self-ligating braces showed more pain than those in the aligners group. Overall, aligners were less painful than conventional and self-ligating appliances. Patients did not suffer from an alteration in their quality of life due to orthodontic treatment.",book:{id:"10780",title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg"},signatures:"Farid Bourzgui, Rania Fastani, Salwa Khairat, Samir Diouny, Mohamed El Had, Zineb Serhier and Mohamed Bennani Othmani"},{id:"80839",title:"Herbs and Oral Health",slug:"herbs-and-oral-health",totalDownloads:69,totalDimensionsCites:0,doi:"10.5772/intechopen.103715",abstract:"Herbal medicine has long been used to prevent and control disease, and it can minimize the potential side effects of chemical products. However, side effects from herbs do exist. Most of the challenges with herbal medicine revolves around inadequate information about the effect of herbs in the oral cavity, the mechanism of action, and potential side effects. There are several herbs described in this chapter have anti-inflammatory, anti-bacterial, anti-viral, anti-fungal in oral micro-organisms. It includes aloe vera, ginger, clove, cinnamon, garlic, neem, miswak, turmeric, tulsi, green tea, chamomile, fenugreek, anise plant, peppermint, bloodroot, caraway, eucalyptus, phyllanthus emblica, black seed, myrrh, rosemary, sage, and thyme; some may act as an alternative management option to current treatments for oral conditions such as caries prevention, gingivitis, periodontitis, oral burn, ulcers and inflammation, after extraction, dry mouth, pain reduction, anesthesia, intracanal medications, ill-fitting dentures, peri-implant mucositis and peri-implantitis. It can be used in several forms such as mouthwashes, toothpastes, topical agents or local drug delivery devices. However, more research is needed to understand their mechanisms and potential side effects.",book:{id:"10827",title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg"},signatures:"Zuhair S. Natto"},{id:"80441",title:"Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact",slug:"periodontitis-and-heart-disease-current-perspectives-on-the-associative-relationships-and-preventive",totalDownloads:65,totalDimensionsCites:0,doi:"10.5772/intechopen.102669",abstract:"Due to the important advancement and the accumulation of new evidence on the periodontitis-cardiovascular disease (CVD) relationship as well as the major medical, economic and social burden caused by both diseases this chapter aims to review existing epidemiological and pathogenetic links related to this topic. Also, this chapter aims to highlight the impact of the periodontitis-CVD relationships on clinical practice and on the preventive approaches targeting to decrease the impact of periodontitis on CVD. Periodontitis is an infectious disease eliciting local and general inflammation, which leads to periodontal destruction and systemic involvement. Several pathways could explain the link between periodontitis and CVD such as bacteraemia, chronic persistent systemic inflammation and oxidative stress. The first step in the treatment of periodontitis addresses the elimination of microbial components, which lead to a decrease in local and systemic inflammation. Periodontal therapy seems to positively impact CVD. Specialists should inform patients with CVD on the negative impact of periodontitis on their systemic status and refer patients to the periodontist for an extensive examination as routine management of CVD. Some possible risks of periodontal therapy should be considered in patients undergoing antithrombotic medication.",book:{id:"10827",title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg"},signatures:"Alexandra Roman, Andrada Soancă, Bogdan Caloian, Alexandru Bucur, Gabriela Valentina Caracostea, Andreia Paraschiva Preda, Dora Maria Popescu, Iulia Cristina Micu, Petra Șurlin, Andreea Ciurea, Diana Oneț, Mircea Viorel Ciurea, Dragoș Alexandru Țermure and Marius Negucioiu"},{id:"79498",title:"Oral Aspects and Dental Management of Special Needs Patient",slug:"oral-aspects-and-dental-management-of-special-needs-patient",totalDownloads:109,totalDimensionsCites:0,doi:"10.5772/intechopen.101067",abstract:"Individuals with special needs are the most underserved regarding healthcare needs in almost all populations. Special needs patients with intellectual disability have muscle coordination disorder, impaired oral motor function, drooling, weak muscles that cause chewing and swallowing problems. Also, soft diet consumption makes this population more prone to dental disease. They have more caries, missing teeth, orthodontic and periodontal problems. Besides more difficulties obtaining professional dental care than other segments of the population. Though many countries developed community-based systems to improve oral health for people with special needs, providing good oral health mainly depends on the effort of the families. Therefore the education of the caregiver about oral hygiene provision is also critical for the special needs patient to enjoy a lifetime of oral health the same as other members of the society.",book:{id:"10827",title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg"},signatures:"Pinar Kiymet Karataban"},{id:"79699",title:"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva",slug:"metabolomics-distinction-of-cigarette-smokers-from-non-smokers-using-non-stationary-benchtop-nuclear",totalDownloads:56,totalDimensionsCites:0,doi:"10.5772/intechopen.101414",abstract:"Implementations of high-field nuclear magnetic resonance (NMR) facilities into metabolomics studies are unfortunately restricted by their large dimensions, high costings, and specialist technical staff requirements. Therefore, here the application and practical advantages offered by low-field (60 MHz), compact NMR spectrometers for probing the metabolic profiles of human saliva was explored, as was their value in salivary metabolomics studies. Saliva samples were collected from cigarette smoking (n = 11) and non-smoking (n = 31) human participants. 1H NMR spectra were acquired on both low-field (60 MHz) and medium-field (400 MHz) spectrometers. Metabolomics analyses were employed to evaluate the consistencies of salivary metabolite levels determined, and their abilities to distinguish between smokers and non-smokers. Low-field 1H NMR analysis detected up to 15, albeit permitted the reliable quantification of 5, potentially key diagnostic biomolecules simultaneously (LLOQ values 250–400 μmol/L), although these were limited to those with the most prominent resonances. Such low-field profiles were also found to be suitable for salivary metabolomics investigations, which confirmed the successful discrimination between smoking and non-smoking participant sample donors. Differences observed between these groups were largely ascribable to upregulated salivary levels of methanol, and its metabolite formate, in the smoking group, but higher smoking-mediated concentrations of acetate, propionate and glycine may arise from a diminished salivary flow-rate in these participants. In conclusion, determination of salivary biomolecules using low-field, benchtop 1H NMR analysis techniques were found to be valuable for bioanalytical and metabolomics investigations. Future perspectives for the applications of this non-stationary NMR technique, for example for the on-site ‘point-of-care’ testing of saliva samples for diagnostic oral disease screening purposes at dental surgeries and community pharmacies, are considered.",book:{id:"10827",title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg"},signatures:"Benita C. Percival, Angela Wann, Sophie Taylor, Mark Edgar, Miles Gibson and Martin Grootveld"}],onlineFirstChaptersTotal:36},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"1",title:"Oral Health",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",isOpenForSubmission:!0,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"2",title:"Prosthodontics and Implant Dentistry",coverUrl:"https://cdn.intechopen.com/series_topics/covers/2.jpg",isOpenForSubmission:!0,editor:{id:"179568",title:"Associate Prof.",name:"Wen Lin",middleName:null,surname:"Chai",slug:"wen-lin-chai",fullName:"Wen Lin Chai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHGAQA4/Profile_Picture_2022-05-23T14:31:12.png",biography:"Professor Dr. Chai Wen Lin is currently a lecturer at the Department of Restorative Dentistry, Faculty of Dentistry of the University of Malaya. She obtained a Master of Dental Science in 2006 and a Ph.D. in 2011. Her Ph.D. research work on the soft tissue-implant interface at the University of Sheffield has yielded several important publications in the key implant journals. She was awarded an Excellent Exchange Award by the University of Sheffield which gave her the opportunity to work at the famous Faculty of Dentistry of the University of Gothenburg, Sweden, under the tutelage of Prof. Peter Thomsen. In 2016, she was appointed as a visiting scholar at UCLA, USA, with attachment in Hospital Dentistry, and involvement in research work related to zirconia implant. In 2016, her contribution to dentistry was recognized by the Royal College of Surgeon of Edinburgh with her being awarded a Fellowship in Dental Surgery. She has authored numerous papers published both in local and international journals. She was the Editor of the Malaysian Dental Journal for several years. Her main research interests are implant-soft tissue interface, zirconia implant, photofunctionalization, 3D-oral mucosal model and pulpal regeneration.",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},editorTwo:{id:"479686",title:"Dr.",name:"Ghee Seong",middleName:null,surname:"Lim",slug:"ghee-seong-lim",fullName:"Ghee Seong Lim",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003ScjLZQAZ/Profile_Picture_2022-06-08T14:17:06.png",biography:"Assoc. Prof Dr. Lim Ghee Seong graduated with a Bachelor of Dental Surgery from University of Malaya, Kuala Lumpur in 2008. He then pursued his Master in Clinical Dentistry, specializing in Restorative Dentistry at Newcastle University, Newcastle, UK, where he graduated with distinction. He has also been awarded the International Training Fellowship (Restorative Dentistry) from the Royal College of Surgeons. His passion for teaching then led him to join the faculty of dentistry at University Malaya and he has since became a valuable lecturer and clinical specialist in the Department of Restorative Dentistry. He is currently the removable prosthodontic undergraduate year 3 coordinator, head of the undergraduate module on occlusion and a member of the multidisciplinary team for the TMD clinic. He has previous membership in the British Society for Restorative Dentistry, the Malaysian Association of Aesthetic Dentistry and he is currently a lifetime member of the Malaysian Association for Prosthodontics. Currently, he is also the examiner for the Restorative Specialty Membership Examinations, Royal College of Surgeons, England. He has authored and co-authored handful of both local and international journal articles. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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