Marisa Repetto

University of Buenos AiresArgentina

MARISA GABRIELA REPETTO Birth date: July 9, 1965. Birthplace: Buenos Aires, Argentina. Country: Argentina. Current Position: Professor Assistant of the University of Buenos Aires. General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. Junín 956, 1113. Buenos Aires. Argentina. Tel: (5411) 964-8249. Fax: (5411) 964-3653. E-mail: mrepetto@ffyb.uba.ar 1. Education Institution: University of Buenos Aires. Argentina. M.S. in Biochemistry (1991). School of Pharmacy and Biochemistry. University of Buenos Aires, 1991. Ph.D. (2001). School of Pharmacy and Biochemistry. University of Buenos Aires. Doctoral Thesis: “Study of oxidative damage markers in pathologies. Evaluation of effects of antioxidant compounds in treatment diseases” Authorized Teacher of the University of Buenos Aires. School of Pharmacy and Biochemistry. University of Buenos Aires December, 2005. Scientist Researcher of University of Buenos Aires, Ministerio de Educación de la Nación: Category 3. 2. Actual Institutional Position Assistant Professor. General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. Scientific production 3. Publications in International journals with peer-review process 1. Gonzalez Flecha B, Repetto M, Evelson P, Boveris A. Inhibition of microsomal lipid peroxidation by a -Tocopherol and a -Tocopherol Acetate. Xenobiotica 21: 1013–1022 (1991) 2. Gatto E, Carreras MC, Pargament G, Reides C, Repetto M, Llesuy S, Fernandez Pardal M, Poderoso J. Neutrophil function nitric oxid and blood oxidative stress in Parkinson’s disease. Mov Disord 11: 261-267 (1996) 3. Repetto M, Reides C, Gomez Carretero M, Costa M, Griemberg G, Llesuy S. Oxidative Stress in Erythrocytes of HIV infected patients. Clin Chim Acta 255: 107-117 (1996) 4. Famulari A, Marschoff E, Llesuy S, Kohan S, Serra J, Dominguez R, Repetto M, Reides C, Sacerdote de Lustig E. Antioxidant enzymatic blood profiles associated with risk factors in Alzheimer’s and vascular diseases a predictive assay to differentiate demented subjects and controls. J Neurol Sci 141: 69-78 (1996) 5. Desmarchelier C, Repetto M, Ciccia G, Llesuy S, Coussio J. Total reactive antioxidant potential (TRAP).and total antioxidant reactivity (TAR) of medicinal plants used in South-West Amazonia (Bolivia and Perú). Int J Pharmacog 35: 1-9 (1997) 6. Gatto E, Carreras C, Pargament G, Riobó N, Reides C, Repetto M, Fernandez Pardal N, Llesuy S, Poderoso J. Neutrophyl function nitric oxide and blood oxidative stress in Parkinson´s Disease. Focus Parkinson´s Dis 9: 12-14 (1997) 7. Desmarchelier C, Repetto M, Coussio J, Ribeiro Latorre L, Kato M, Barros S, Ciccia G. 4-nerolydilcatechol from Pothomorphe spp. inhibits in vitro generation of peroxyl radicals and Fe (II)-dependent DNA damage. Planta Med 63: 5 61-563 (1997) 8. Repetto M, Reides C, Evelson P, Kohan S, Sacerdote de Lustig E, Llesuy S. Peripheral markers of oxidative stress in probable Alzheimer patients. Eur J Clin Invest 29: 643-649 (1999) 9. María A, Repetto M, Llesuy S, Guzmán J, Giordano O, Guerreiro E. Antioxidant Activity of Artemisisa douglasiana Besser extract and Dehidroleucodine. Phytother Res 14: 558-560 (2000) 10. Evelson P, Travacio M, Repetto M, Escobar J, Llesuy S, Lissi E. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch Biochem Biophys 388: 261-266 (2001) 11. Repetto M, Llesuy S. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 35: 523-534 (2002) 12. Fiszman M, D´Eigidio M, Ricart K, Repetto M, Llesuy S, Borodinsky L, Trigo R, Riedstra S, Costa P, Saizar R, Villa A, Sica R. Evidences of oxidative stress in Familial Amyloidotic Polyneuropathy Type 1. Arch Neurol 60: 593-597 (2003) 13. Repetto M, María A, Giordano O, Guzmán J, Guerreiro E, Llesuy S. Protective effect of Artemisia douglasiana Besser extracts on ethanol induced oxidative stress in gastric mucosal injury. J Pharm Pharmacol 55: 551-557 (2003) 14. Abalovich M, Llesuy S, Gutierrez S, Repetto M. Peripheral markers of oxidative stress in Grave´s disease. The effects of Methimazole and 131 Iodine treatment. Clin Endocrinol 59: 321-327 (2003) 15. Repetto M, Llesuy S. Peripheral markers of oxidative stress in neurological patients. Reprinted from XIII Bienal Meeting of the Society for Free Radical Research Internacional (SFRR). Med Inter Proc. Monduzzi Ed Int Proc Div 251-255 (2004) 16. Ansaldo M, Repetto M, Montalti D. Comparison of blood antioxidant responses among Catharacta maccormicki (South Polar skua) and Catharacta antarctica lönnbergi (Brown skua). Berichte zur Polar und Meeresforschung 507: 113-116 (2005) 17. Ossani G, Dalghi M, Repetto M. Oxidative damage and lipid peroxidation in the kidney of choline-defficient rats. Front Biosci 12: 1174-1183 (2007) 18. Domínguez R, Marschoff E, Guareschi E, Repetto M, Famulari A, Pagano M, Serra J. Insulin, glucose and glycated haemoglobin in Alzheimer´s and vascular dementia with and without superimposed Type II diabetes mellitus condition. J Neur Transm. 115: 77-84. (2008). 19. Gorzalczany S, Muschietti L, Repetto M, Kartin L, Ferraro G, Martino V, Acevedo C. Choleretic and antioxidant effect of Eupatorium bunifolium. Pharmacologyonline. 1: 139-147. (2008). 20. Repetto M, Ossani G, Monserrat A, Boveris A. Oxidative damage: The biochemical mechanism of cellular injury and necrosis in choline deficiency. Exp Mol Pathol. 88: 143-149. (2010). 21. Repetto M, Ferrarotti N, Boveris A. The involvement of transition metal ions on iron depended lipid peroxidation. Arch Toxicol. 84: 255-262. 22. Repetto M, Boveris A. Bioactivity of sesquiterpenes: nobel compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage. Mini Reviews in Medicinal Chemistry. 10: 615-623 (2010). 3.2. International publications in journals without peer-review process 1. Repetto M, Griemberg G, Llesuy S. Marcadores periféricos de estrés oxidativo en diferentes patologías. http:// Sección Expertos invitados http://www.siicsalud. com/main/expeinv. htm de la Soc Iberoam Inform Cien (2001) 2.. Repetto M, Llesuy S. Correlación entre los marcadores bioquímicos de estrés oxidativo y parámetros clínicos en la infección por VIH. Ant Vit Nutr 2: 2-5. (2007). Versión web en www.antioxidantes.com.ar. 3.3. National publications 1. Repetto M, Griemberg G, Llesuy S. Empleo de técnicas de quimioluminiscencia para la evaluación de marcadores periféricos de estrés oxidativo en sangre de pacientes infectados por HIV. Bioq Pat Clín 63: 24-35 (1999). 2. Repetto M, Llesuy S. Especies reactivas del oxígeno y estrés oxidativo asociados a la infección por HIV. Ant Cal Vida 5: 8-19 (1999) 3. Repetto M. Peripheral markers of oxidative stress in Alzheimer patients. Dosis. Pharmaceutical Actualization. (2004) 4. Chapter in books 1. Repetto M. Clinical use of chemiluminescence assays for the determination of systemic oxidative stress. In: Handbook of chemiluminescent methods in oxidative stress assessment. (Popov I, ed.), Research Signpost, India. 9: pp. 163-194 (2008). 2. Boveris A, Repetto M, Boveris AD, Valdez L. El concepto de estrés oxidativo en patología. In: Radicales libres y estrés oxidativo en la salud y en la enfermedad. (Konigsberg M, ed.), El Manual Moderno, México, p. 311-322 (2008). 3. Repetto M, Ossani G. Sequential histopathological and oxidative damage in different organs in choline deficient rats. In: Free Radical Pathophysiology. (Alvarez S, Evelson E, Boveris A, eds.), Research Signpost, Kerala, India, p. 433-450 (2008). 4. Boveris A, Repetto M, Bustamante J, Boveris AD, Valdez L. The concept of oxidative stress in pathology. In: Free Radical Pathophysiology. (Alvarez S, Evelson P, Boveris A, eds.), Research Signpost, Kerala, India, p. 1-17. (2008). 5. Llesuy S, Pavanato A, Baldiserotto B, Reides C, Ferreira S, Repetto M. Contaminación acuática con Tório y su relación con el daño oxidativo. In: Desafíos del cambio climático y global en Argentina, Eudeba, Editorial Universitaria de Buenos Aires (ed.), Buenos Aires, Argentina, p. 295-296 (2009) 6. Conferences 1. XV Annual Reunion of the Federation of Experimental Biology. XXV Brazilian Congress of Biophysics. XXXV Brazilian Congress of Physiology. XXIV Brazilian Congress of Neuroscience and Comportment. Subject: South American plant antioxidant capacity. Digestive applications. August 26, 2000. 2. Oxidative Stress and Neurodegenerative Diseases. Subject: Markers of oxidative stress in neurodegenerative diseases. National Academy of Pharmacy and Biochemistry. University of Buenos Aires. September 23, 2004. 3. VI International Medical Meeting, Antioxidants and Life Care. Subject: Oxidative stress in HIV infection. August 25, 2005. 4. XIV Congress of Endocrinology and Metabolism. Symposium on Hypogonadism. Buenos Aires, Argentina. Subject: Peripheral markers of oxidative stress in hypogonadism. September 4, 2005. 5. International Meeting of Education in Health and Ambient. International Japan Cooperative. Health group. Buenos Aires, Argentina. Subject: Toxicological effects of heavy metals. November, 2007. 7. Oral Communications 1. Repetto M, Abalovich M, Llesuy S. Evaluation of oxidative stress markers in Graves Disease under metilmercaptoimidazol and I131 treatments. XLIV Scientific Meeting of the Argentine Society of Clinical Investigation (SAIC). Mar del Plata. Buenos Aires. Argentina. November 17-20, 1999. 2. Repetto M, Mormandi E, Aszpis S, Sandonato N, Carle G, García L, Llesuy S, Levalle O. Androgenic impact on oxidative stress parameters. XIV Congress of Endocrinology and Metabolism. Buenos Aires, Argentina. September 4-6, 2005. 3. Repetto M, Abalovich M, Gutierrez S, Dalghi M, Pappalardo V, Morasutti M, Llesuy S. Oxidative stress markers in clinical and subclinical hypotyroidism. Effects of levotiroxine treatment. XIV Congress of Endocrinology and Metabolism. Buenos Aires, Argentina. September 4-6, 2005. 4. Repetto M, Dalghi M, Boveris,A, Ossani G, Lago N, Monserrat A. Oxidative damage associated to heart injury caused by choline deficiency. IV Meeting of the South American Group of the Society for Free Radical Biology and Medicine. South American Group of the Society for Free Radical Biology and Medicine. Aguas de Lindoia. Brasil. 2005. 8. Scientific lessons 1. Peripheral markers of oxidative stress in viral infections. Actualization Meeting on Oxidative Stress. PRALIB. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. April 5, 2004. 2. Peripheral markers of oxidative stress in viral infections. Clinical Immunology. Clinical Biochemistry Department. School of Pharmacy and Biochemistry. University of Buenos Aires. Mayo 26, 2005. 3. Peripheral markers of oxidative stress in plasma and erythrocytes. Physicochemical Division. School of Pharmacy and Biochemistry. University of Buenos Aires. Workshop of Oxidative Stress in Human Pathologies. October 26, 2005. 4. Biochemical mechanisms of injury and tissular necrosis in choline deficiency. School of Pharmacy and Biochemistry. University of Buenos Aires. September 11, 2008. 9. Scientific congress Out of the 67 scientific works presented in international and national congresses, 33 of them were published in peer-reviewer journals. 10. Teaching curriculum Actual position Assistant Professor. General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. Grade courses Instructor teacher in General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. 1992-2006. Instructor teacher in Capacitating and Formation Course for Auxiliary Teachers in General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires.1996-2010. Post- grade courses I have participate as co-director in 2 national curses, as teacher coordinator in one national curse, as instructor in 8 international and 18 national curses in General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. 11. Institutional participation 1992-2007. Represent of auxiliary teachers of General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. Scientific Reviewer 1997. Evaluator of projects for the incentive Program of the Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. 1997. Reviewer in the XXII National Science and Technology Feria. Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. University of Buenos Aires. Río Gallegos. Santa Cruz. Argentina. 1998. Reviewer in the XXIII National Science and Technology Feria. Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. Area of Scientific and technological juvenile activities. Argentina. 2002. XXIII National Science and Technology Feria. Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. University of Buenos Aires. Tierra del Fuego. Argentina. 2007. XXXI National Science and Technology Feria. Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. University of Buenos Aires. 2010. Member of the coordinator panel in the Meeting of the Society of Argentinean Clinical Investigation. 2010. Member of the tribunal of professors responsible for designing teacher affiliation in the Faculty of Pharmacy and Biochemistry. University of Buenos Aires. 12. Research Teaching Doctoral thesis direction 2005-actually. Doctoral thesis direction of Biochemist Nidia Ferrarotti. Subject: Effects of transition metals in the biochemical processes of oxidative damage. Study of the association with markers of the inflammatory response. Area: Physiopathology. General and Inorganic Chemistry. Department of Analytical and Physical Chemistry. School of Pharmacy and Biochemistry. University of Buenos Aires. Students direction 2006. Scholarship Stimulus 2006 University of Buenos Aires. Student: Marianela Dalghi. Subject: Biochemical effects of oxidative damage to lipids and proteins on the ionic transport across brain cellular membrane. Distinctions and awards 1992, 1993, 1994. Award for Scientific and Technological production. University of Buenos Aires. School of Pharmacy and Biochemistry. 1998. Distinction for Reviewers by Secretary of Science and Technology of the Ministry of Culture and Education of Argentina. Buenos Aires, Argentina. 2004. Award for Scientific production, National Academy of Pharmacy and Biochemistry. Analytical chemistry: Santiago Celsi. Luminescent method for the determination of antioxidant capacity. 14. Scientific affiliations 1. Titular member of the Oxygen Society. San Francisco. CA. USA, 1996-actually. 2. Medical Columnist Expert Invited of the Iberoamerican Society of Scientific Information (SIIC Heath), 2000-actually. 3. Member of the International Reviewers Panel of Medical Science Monitor, 2003-actually. 4. Titular member of the Argentine Society of Clinical Investigation. 2006-actually. 15. Economical Financial of Research a. As titular 2003. UBACyT for young researchers: Is syphilis associated to oxidative stress? (B412). University of Buenos Aires. Director. 2004-2005. UBACyT: Syphilis: Epidemiological pattern in Buenos Aires city. Relation between clinical status and oxidative stress and immunological peripheral markers (B092). Director: Prof. Gloria Griemberg Gutierrez. Co-director: Dra. Marisa Repetto. University of of Buenos Aires. Co-director. 2006-2009. UBACyT: Biochemical consequences of oxidative damage to lipids and proteins on transport ionic channels of plasmatic and mitochondrial membranes of liver, kidney and brain (B809). Director. 2008-2010. UBACyT: Biochemical processes of oxidative damage in experimental pathology. Effect of transition metals (B056). Director. b. As collaborator 1992-1994. Development of new methodologies for oxidative stress determination in erythrocytes. Argentina. Director: Dr. Susana Llesuy. 1992-1994. UBACyT: Development of new methodologies for oxidative stress determination in erythrocytes. University of Buenos Aires. Director: Dr. Susana Llesuy. 1995-1997. UBACyT: Antioxidants in biological systems. University of Buenos Aires. Director: Dr. Susana Llesuy. 1995-1997. Antorchas Fundation. Antioxidants in biological systems. University of Buenos Aires. Director: Dr. Susana Llesuy. 1998-2000. UBACyT: Antioxidants in biological systems: Antioxidative prevention of oxidative stress by antioxidants of vegetal origin (TB045). University of Buenos Aires. Director: Dr. Susana Llesuy. 2000-2002. UBACyT: Antioxidants in biological systems: Prevention of oxidative damage by plant (TB050). University of Buenos Aires. Director: Dr. Susana Llesuy. 2004-2006. UBACyT: Antioxidants in biological systems: Evaluation of potential antioxidant compound in different pathologies (B124) Director: Dr. Susana Llesuy. University of Buenos Aires. 2006. Project for Modernization of Research Laboratory Equipment. PME. Proyect PME-2006-02108: Nuclear Magnetic Resonance of solid status and solution for development and control of medication quality (node 4). Director: Dr. Alberto Boveris. 2008-2010. UBACyT: Oxide-reduction process in biological systems. Evaluation of potential antioxidant compounds in different pathologies (B024). Director: Dr. Susana Llesuy. University of Buenos Aires. 16. Other financial sources. Technological activity. 2003-actually: Technical assistance and determinations of antioxidant capacity of biological fluids and natural compounds. Laboratory of oxidative stress determinations. Sub-Secretary of Technological Transfer. Science and Technical Secretary. School of Pharmacy and Biochemistry. University of Buenos Aires. Director: Dr. Marisa Repetto.

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