Joseph Ongrádi

Semmelweis UniversityHungary

Joseph Ongrádi graduated as MD at the Semmelweis University of Medicine, Budapest, Hungary, in 1976. At this university, he obtained his PhD at the Institute of Microbiology. He is a board-certified medical microbiologist and clinical biologist and has habilitation in medical microbiology. Between 1998 and 2005, he was the Head of Microbiology Laboratory, Department of Dermato-Venereology; between 2005 and 2010, he was the head of the Immunovirology Laboratory, Department of Public Health, and he returned to the Department of Medical Microbiology in 2011. His interests include latency, reactivation, interaction of herpesviruses, adenoviruses, and retroviruses. He described the role of Roseoloviruses in skin diseases, multiple sclerosis and AIDS, and two bacterium species as sexually transmitted infections and isolated the first Adenovirus from Felidae in the feline AIDS model.

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Latest work with IntechOpen by Joseph Ongrádi

Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed. Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses.

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