Tsz Kwong Man

Dr. Chris Man is an Associate Professor of Pediatrics at Baylor College of Medicine where he participates in the Bone Tumor Program and the Cancer Genetics and Genomics Program at Texas Children’s Cancer Center. Dr. Chris Man’s laboratory is interested in applying computational and OMICS approaches to improve both the diagnosis and prognosis of pediatric cancer patients. The main focus of his research is to identify circulating and tumor biomarkers for early detection of chemoresistance and metastasis in pediatric osteosarcoma. Dr. Man and his lab are also interested in using bioinformatic and meta-analysis approaches to identify novel drug targets and pathways in pediatric cancers. The current projects include: 1) molecular classification of pediatric cancers based on genomic and proteomic profiling; 2) development of computational tools to integrate and analyze large-scale datasets; and 3) biomarker and target discovery in pediatric cancers using novel technologies.

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Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

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