Chapters authored
Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies
Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a framework for current research of NC and gas plasma therapies for lung cancer. Herein, we focus on the application of gas plasmas and nanotechnology to drug and gene delivery and highlight several outcomes of its. The types and features of the mentioned therapeutics strategy as novel classes for treating lung cancer individually and synergistic were examined.
Part of the book: Lung Cancer
Nano Technology and Gas Plasma as Novel Therapeutic Strategies for Ovarian Cancer Oncotherapy
Ovarian cancer (OC) is associated with a high rate of resistance to most chemotherapy drugs and thus novel therapies are crucial to overcoming these obstacles. The technological advances in nanotechnology make it possible to adapt these approaches for the treatment of chemo-resistant OC. In parallel, it is also evident that this emerging technology plays crucial roles in other medical areas including wound healing, treatment of viral infection and applications in dentistry. With the advancement of nanotechnology, nano dependent therapies are attractive viable alternatives to conventional therapies for various diseases, especially cancers. Nanoparticles (NPs) are a suitable platform for cytotoxic agent delivery and aiding early diagnosis of disease, which can lead to improving outcomes for these patients. Gas plasma oncotherapy is an innovative modality and shows huge potentials in cancer treatment and may emerge as the fifth cancer treatment modality together with surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy. The combination of nanoparticle and gas plasma therapy could lead to the discovery of an alternative effective treatment approach in these resistant tumors leading to improvement of OC prognosis. Here, we highlighted the two novel modalities with known multiple biological targets and underlying mechanisms appropriate for their application in OC treatment. This chapter explores the utility of combination or multimodal of novel nanotherapeutic agents in the treatment of OC.
Part of the book: Ovarian Cancer