The international neuroblastoma pathology classification of neuroblastoma (Shimada system) [1].
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8629",leadTitle:null,fullTitle:"Visions of Cardiomyocyte - Fundamental Concepts of Heart Life and Disease",title:"Visions of Cardiomyocyte",subtitle:"Fundamental Concepts of Heart Life and Disease",reviewType:"peer-reviewed",abstract:"In the field of cardiology, some of the most dramatic advances in recent years have come from understanding the molecular and cellular basis of cardiovascular disease. Knowledge of the pathological basis of disease in some cases allows the development of new strategies for prevention and treatment. This book was planned not only to convey new facts on cardiovascular diseases, but also to boost the excitement and challenges of research in the dynamic area of modern molecular and cellular biology of cardiology. The integration of multilevel biological data and the connection with clinical practice reveal the potential of personalized medicine, with future implications for prognosis, diagnosis, and management of cardiovascular diseases.",isbn:"978-1-78985-556-2",printIsbn:"978-1-78985-555-5",pdfIsbn:"978-1-78985-929-4",doi:"10.5772/intechopen.79311",price:119,priceEur:129,priceUsd:155,slug:"visions-of-cardiomyocyte-fundamental-concepts-of-heart-life-and-disease",numberOfPages:130,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"1cae2b319d6f3c230849834f10715701",bookSignature:"Angelos Tsipis",publishedDate:"January 29th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8629.jpg",numberOfDownloads:5406,numberOfWosCitations:3,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:10,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 5th 2018",dateEndSecondStepPublish:"September 25th 2018",dateEndThirdStepPublish:"November 24th 2018",dateEndFourthStepPublish:"February 12th 2019",dateEndFifthStepPublish:"April 13th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"77462",title:"Dr.",name:"Angelos",middleName:null,surname:"Tsipis",slug:"angelos-tsipis",fullName:"Angelos Tsipis",profilePictureURL:"https://mts.intechopen.com/storage/users/77462/images/7888_n.jpg",biography:"Dr. Tsipis holds a diploma in Medicine (MD) from Medical School, University 'TorVergata”, Rome, Italy. He also holds a PhD from National and Kapodistrian University of Athens, Greece. He received prizes (6) for best research achievement in International and National Congresses. He has published more than 60 scientific papers in International Journals and conference proceedings, 65 publications in national journals and 2 International book chapters. He is a member of the editorial board of 6 scientific journals, reviewer of 10 journals and member of international and national medical societies. His interests cover cardiovascular pathology, molecular cardiology, apoptosis in ischemic cardiomyopathy and dilated cardiomyopathy.",institutionString:"University of Athens",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"170",title:"Cardiology and Cardiovascular Medicine",slug:"cardiology-and-cardiovascular-medicine"}],chapters:[{id:"70268",title:"Introductory Chapter: Cardiomyocyte - Fundamental Unit of Heart Life and Disease",doi:"10.5772/intechopen.90103",slug:"introductory-chapter-cardiomyocyte-fundamental-unit-of-heart-life-and-disease",totalDownloads:598,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Angelos Tsipis",downloadPdfUrl:"/chapter/pdf-download/70268",previewPdfUrl:"/chapter/pdf-preview/70268",authors:[{id:"77462",title:"Dr.",name:"Angelos",surname:"Tsipis",slug:"angelos-tsipis",fullName:"Angelos Tsipis"}],corrections:null},{id:"65825",title:"Right Heart Adaptation to Left Ventricular STEMI in Rats",doi:"10.5772/intechopen.84868",slug:"right-heart-adaptation-to-left-ventricular-stemi-in-rats",totalDownloads:648,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Development of right ventricular (RV) failure in patients after ST-segment elevation myocardial infarction (STEMI) is common. However, a systematic analysis of chamber-specific changes in the expression of genes linked to cardiac function, apoptosis, fibrosis, receptor responsiveness, and inflammation is lacking. Postischemic remodeling was analyzed in rats that received STEMI in the closed chest mode. Rats were sacrificed at day 1, 3, 7, and 120 after surgery. The mRNA expression of genes was quantified by a real-time RT-PCR. Echocardiography was performed after 120 days. Organ weights and systemic blood pressure were determined in addition. Rats developed left and RV dysfunction within 7 days after ischemia/reperfusion and this lasted until the end of the experiments. However, adaptation to ischemia/reperfusion differed significantly between both ventricles. In the LV, a high expression of MMP12, a neutrophile-specific elastase, indicated a significant inflammatory responsiveness that did not occur in RV. A number of differentially regulated genes in the RV exceeded that of the LV at day 3. Postinfarction RV failure is common in rats with ischemia/reperfusion of the left arterial descending aorta. It is associated with severe RV remodeling that occurred delayed to that of the LV. Changes in RV are independent of the initial inflammation.",signatures:"Rolf Schreckenberg and Klaus-Dieter Schlüter",downloadPdfUrl:"/chapter/pdf-download/65825",previewPdfUrl:"/chapter/pdf-preview/65825",authors:[{id:"276177",title:"Prof.",name:"Klaus-Dieter",surname:"Schlüter",slug:"klaus-dieter-schluter",fullName:"Klaus-Dieter Schlüter"},{id:"288191",title:"Dr.",name:"Rolf",surname:"Schreckenberg",slug:"rolf-schreckenberg",fullName:"Rolf Schreckenberg"}],corrections:null},{id:"65021",title:"Myocardial Infarction and Circadian Rhythm",doi:"10.5772/intechopen.83393",slug:"myocardial-infarction-and-circadian-rhythm",totalDownloads:1007,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Human physiological activity and condition during illness are under the control of the circadian rhythm. Circadian rhythms handle a wide diversity of physiological and metabolic functions, and the interruption of these rhythms has been linked to obesity, sleep disorders, metabolic and psychological disorders, and cardiovascular events such as myocardial infarction (MI), stroke, and vascular death. Disruption of circadian rhythms increases the risk of developing myocardial infarction, indicating that circadian genes might play an essential role in determining disease susceptibility. It is well known that many cardiovascular processes show daily variations depending on the circadian rhythm (blood pressure, heart rate), and the gene expression of the cardiomyocyte circadian clock influences myocardial contractile function, metabolism, and other gene expressions. We present a review of the latest knowledge on the impact of circadian rhythm and circadian rhythm genes on myocardial infarction. Today, in a time of personalized medicine, it is essential to know each person’s circadian rhythm for its treatment and possible inclusion in the diagnostic procedures.",signatures:"Ivana Škrlec, Svjetlana Marić and Aleksandar Včev",downloadPdfUrl:"/chapter/pdf-download/65021",previewPdfUrl:"/chapter/pdf-preview/65021",authors:[{id:"272772",title:"Ph.D.",name:"Ivana",surname:"Škrlec",slug:"ivana-skrlec",fullName:"Ivana Škrlec"},{id:"274496",title:"Prof.",name:"Svjetlana",surname:"Marić",slug:"svjetlana-maric",fullName:"Svjetlana Marić"},{id:"283988",title:"Prof.",name:"Aleksandar",surname:"Včev",slug:"aleksandar-vcev",fullName:"Aleksandar Včev"}],corrections:null},{id:"65320",title:"Current Pathophysiological and Genetic Aspects of Dilated Cardiomyopathy",doi:"10.5772/intechopen.83567",slug:"current-pathophysiological-and-genetic-aspects-of-dilated-cardiomyopathy",totalDownloads:1149,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Dilated cardiomyopathy is the most common form of cardiomyopathy and the second leading cause of left ventricular dysfunction with highly variable clinical presentation and prognosis. The clinical courses vary and are strongly heterogeneous, ranging from asymptomatic patients to those suffering from intractable heart failure or sudden cardiac death due to arrhythmias. Previous studies have reported a 10 years cardiovascular mortality up to 40% in developed countries, due to advanced heart failure or sudden cardiac death. However, the prognosis of dilated cardiomyopathy patients is variable and depends on multiple risk factors. This chapter provides a review of dilated cardiomyopathy with specific focus on the pathophysiological aspects and genetic etiology of the disease.",signatures:"Deborah P. Schild, Sascha I. Ricciardi, Jens G. Hellige, Rolf Vogel and Nisha Arenja",downloadPdfUrl:"/chapter/pdf-download/65320",previewPdfUrl:"/chapter/pdf-preview/65320",authors:[{id:"221511",title:"Dr.",name:"Nisha",surname:"Arenja",slug:"nisha-arenja",fullName:"Nisha Arenja"},{id:"221978",title:"Dr.",name:"Deborah P.",surname:"Schild",slug:"deborah-p.-schild",fullName:"Deborah P. Schild"},{id:"221979",title:"Prof.",name:"Rolf",surname:"Vogel",slug:"rolf-vogel",fullName:"Rolf Vogel"},{id:"221980",title:"Dr.",name:"Gerrit",surname:"Hellige",slug:"gerrit-hellige",fullName:"Gerrit Hellige"},{id:"285626",title:"Dr.",name:"Sascha I.",surname:"Ricciardi",slug:"sascha-i.-ricciardi",fullName:"Sascha I. Ricciardi"}],corrections:null},{id:"66751",title:"Modelling of Genetic Cardiac Diseases",doi:"10.5772/intechopen.84965",slug:"modelling-of-genetic-cardiac-diseases",totalDownloads:720,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Cardiac disease modeling is crucial to improve our understanding of the mechanism of various cardiac diseases and to discover new therapeutic approaches. Several modeling methods such as animal and computer simulations have been used to elucidate the cardiac diseases’ mechanism and drug responses. However, each modeling technique has its own particular advantages and limitations. Human-based models would be particularly useful to investigate human cardiac diseases because humans and animals have differing cardiac physiologies and drug tolerability. In addition, the phenotype of cardiac diseases and response to therapeutic intervention differ not only between mutations but also among patients. Therefore, such diseases strongly demand the individualized/personalized strategies. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer the striking feature of retaining the same genetic information as donor, which guide us to investigate diseases and predict response to drug treatment individually. This feature of hiPSC-CMs is superior to the conventional in vitro modeling of cardiac diseases. Thus far, hiPSC-CMs have been successfully recapitulated many monogenic and also complex genetic cardiac diseases. hiPSC-CMs could be differentiated into different types of cardiomyocytes and non-cardiomyocyte cells, which empower us to understand cardiac chamber-specific arrhythmias such as atrial fibrillation and ventricular tachycardia.",signatures:"Chandra Prajapati and Katriina Aalto-Setälä",downloadPdfUrl:"/chapter/pdf-download/66751",previewPdfUrl:"/chapter/pdf-preview/66751",authors:[{id:"20043",title:"Dr.",name:"Katriina",surname:"Aalto-Setälä",slug:"katriina-aalto-setala",fullName:"Katriina Aalto-Setälä"},{id:"278500",title:"Ph.D.",name:"Chandra",surname:"Prajapati",slug:"chandra-prajapati",fullName:"Chandra Prajapati"}],corrections:null},{id:"66901",title:"Obesity-Related Myocardiopathy",doi:"10.5772/intechopen.85949",slug:"obesity-related-myocardiopathy",totalDownloads:442,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cardiovascular disease in populations with obesity is a major concern because of it is epidemic proportion. Obesity leads to the development of cardiomyopathy directly via inflammatory mediators and indirectly by obesity-induced hypertension, diabetes, and coronary artery diseases. Metabolic disturbances such as increased free fatty acid levels, insulin resistance, elevated levels of adipokines, myocardial remodeling, activation of the sympathetic nervous and renin-angiotensin-aldosterone systems, and small-vessel disease are the most important mechanisms in the development of obesity cardiomyopathy. The myocardial changes related with obesity are increasingly recognized, and they are independent of classic risk factors as hypertension, coronary artery disease, and obstructive sleep apnea. There is a wide range of evidence: the association between heart failure and obesity shown in epidemiologic studies; the confirmation of the association of adiposity with left ventricular dysfunction, independent of hypertension, coronary artery disease, and other heart diseases; and experimental evidence of functional and structural changes in the myocardium in response to increased adiposity support the existence of a cardiomyopathy related to obesity.",signatures:"Marco Antonio Lopez Hernandez",downloadPdfUrl:"/chapter/pdf-download/66901",previewPdfUrl:"/chapter/pdf-preview/66901",authors:[{id:"138831",title:"Dr.",name:"Marco Antonio",surname:"López Hernández",slug:"marco-antonio-lopez-hernandez",fullName:"Marco Antonio López Hernández"}],corrections:null},{id:"69437",title:"Roles of Trans and ω Fatty Acids in Health; Special References to Their Differences between Japanese and American Old Men",doi:"10.5772/intechopen.89551",slug:"roles-of-trans-and-fatty-acids-in-health-special-references-to-their-differences-between-japanese-an",totalDownloads:844,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Omega and trans-fatty acids play important roles in atherogenesis of vascular system. In this review, we discuss such roles in health; there are much differences in coronary heart disease (CHD) rates between the US and Japan. Fatty acids profiles in the plasma are related to risks of CHD. There have been few studies that compared plasma levels of fatty acids, including trans-fatty acids, in people in Japan and the US. Plasma levels of long-chain omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) were higher in Japanese men, and omega-6 fatty acids (e.g., arachidonic acid [AA]) were lower compared with American men. American people had higher plasma levels of the major industrially produced trans-fatty acids (IP-TFAs; elaidic and inoelaidic acids), and levels of the potentially cardioprotective, primarily ruminant-derived trans-fatty acid, palmitoelaidic acid (POA) were higher in Japanese men. Plasma levels of saturated or monounsaturated fatty acids were also higher in American men. Only intakes of preference drinks have significant correlation with plasma levels of palmitoelaidic acid and linoelaidic acid. The higher levels of DHA and EPA, along with the lower levels of the IP-TFAs, are consistent with the markedly lower risk for coronary heart disease in Japan vs. the US.",signatures:"Akikazu Takada, Fumiko Shimizu and Shinji Koba",downloadPdfUrl:"/chapter/pdf-download/69437",previewPdfUrl:"/chapter/pdf-preview/69437",authors:[{id:"84834",title:"Prof.",name:"Shinji",surname:"Koba",slug:"shinji-koba",fullName:"Shinji Koba"},{id:"248459",title:"Dr.",name:"Akikazu",surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"},{id:"258324",title:"Prof.",name:"Fumiko",surname:"Shimizu",slug:"fumiko-shimizu",fullName:"Fumiko Shimizu"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6666",title:"Current Perspectives on Cardiomyopathies",subtitle:null,isOpenForSubmission:!1,hash:"3e157b11a418b2bf79c3e39baaac8d2f",slug:"current-perspectives-on-cardiomyopathies",bookSignature:"Angelos Tsipis",coverURL:"https://cdn.intechopen.com/books/images_new/6666.jpg",editedByType:"Edited by",editors:[{id:"77462",title:"Dr.",name:"Angelos",surname:"Tsipis",slug:"angelos-tsipis",fullName:"Angelos Tsipis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6209",title:"Endothelial Dysfunction",subtitle:"Old Concepts and New Challenges",isOpenForSubmission:!1,hash:"f6e76bbf7858977527679a6e6ad6a173",slug:"endothelial-dysfunction-old-concepts-and-new-challenges",bookSignature:"Helena Lenasi",coverURL:"https://cdn.intechopen.com/books/images_new/6209.jpg",editedByType:"Edited by",editors:[{id:"68746",title:"Dr.",name:"Helena",surname:"Lenasi",slug:"helena-lenasi",fullName:"Helena Lenasi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7220",title:"Congenital Heart Disease",subtitle:null,isOpenForSubmission:!1,hash:"f59bacfffcccc636ec3082869d10a82e",slug:"congenital-heart-disease",bookSignature:"David C. 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A surface is called wet if the contact angle is less than 90° and nonwet otherwise. A substrate, like dust or pollution, can contribute energetically to the membrane, decreasing its contact angle. Another feature is the magnitude of the surface tension \n
Many solutions can be found in the literature concerning the viscosity dependence on temperature for pure metals [1, 2, 3, 4, 5, 6, 7] and for alloys [8, 9, 10, 11, 12, 13, 14, 15]. Budai et al. have reviewed the existing models used to predict dependence of viscosity on temperature of alloys, for cases where the viscosities of pure components are already known [10, 15, 16, 17, 18] and those that are independent of experimental data [19]. Budai et al. extended the Kaptay unified equation [10] for the viscosity of alloys, which has been named BBK model [20]. The BKK model was shown to fail in the prediction of viscosity for alloy systems with components that melt congruently [21].
\nSolutions for surface tension as a function of temperature are generally based on: Butler formulation [22, 23, 24, 25]; statistical thermodynamics surface density-functional theory [26, 27, 28]; semi-empirical thermodynamic model [29]; and thermodynamic models [30, 31]. All these models are normally specific for certain binary or ternary alloy systems, or they are general but considerably difficult to apply.
\nIn 1992, Egry [32] derived a relation between surface tension and viscosity deduced from statistical mechanics for the melting temperature, based upon the expressions of Fowler [26] for surface tension and Born and Green [33] for viscosity. Both expressions are expressed as integrals over the product of interatomic forces and the pair distribution functions. The author extended this relation to a finite temperature range by using data available in the literature [34].
\nIn this work, by using a straightforward solution for viscosity for molten pure metals [7] and alloys [10], a comparison between numerical simulations and experimental data for the surface tension and viscosity of pure liquid metals and liquid alloys is provided, in order to validate Egry’s relation for pure molten metals [34]. An extension of this relation is derived for multicomponent alloys. The surface tension is calculated and plotted against temperature for ternary and quaternary aluminum alloys.
\nThe modeling section is divided into models dealing with the viscosity of pure metals and multicomponent alloys, and with the surface tension-viscosity relation equations for pure liquid metals and alloys.
\nKaptay [7] derived a unified equation for the viscosity of pure liquid metals as a function of temperature, which encompasses the activation energy and the free volume concept. Based on the Andrade’s equation [35] as a starting approach, the activation energy concept has been incorporated. By combining again with Andrade’s formulation with free volume concept, an equation for the dependence of viscosity of pure metals on temperature has been derived. As this equation obeys both concepts, the authors named it as a unified equation for the viscosity of pure metals. The derived equation for the viscosity of pure metals as a function of temperature is given by,
where \n
An Arrhenius-type viscosity equation can be extended to deal with viscosity of multicomponent alloy, by applying Redlich-Kister polynomial to excess viscosity,
where \n
where \n
then, we have,
where \n
Kaptay [10], based on the Seetharaman-Du Sichen equation, regarding the theoretical relationship between the cohesion energy of the alloy and the activation of viscous flow, proposed the following equation:
where \n
\n\n
Egry [32] derived a relation between surface tension and viscosity deduced from statistical mechanics for a finite temperature range, based upon the expressions of Fowler [26] for surface tension (\n
where \n
In a very similar way, Born and Green [33] derived an expression for the viscosity (\n
where \n
where \n
In 2005, Kaptay [7] derived a surface tension-viscosity relation, as
where \n
Based on the formula originally proposed by Egry [34], a new formula is derived for the relation between surface tension and viscosity for multicomponent alloys, that is,
where \n
Substituting Eq. (12) into Eq. (6), we get,
\nFigure 1 presents the viscosity of pure aluminum as a function of temperature, simulated by Kaptay [7] theoretical model compared to experimental data [37]. The model fits the experimental scatter well, but a correction in the melting temperature for pure aluminum was carried out according to the model description provided in [7], although, for the case of Al, no correction was applied by the author [7]. Figure 2 shows the evolution of viscosity of molten Cu as a function of temperature, where the theoretical model is compared to experimental results [37], where a deviation is noticed for temperatures close to the melting temperature.
\nCalculated viscosities of the pure molten Al as a function of temperature compared to experimental data [
Calculated viscosities of the pure molten Cu as a function of temperature compared to experimental data [
In Figure 3, the viscosity of pure molten silicon is plotted against temperature. As mentioned, the melting temperature of Si has been assumed as \n
Calculated viscosities of the pure molten Si as a function of temperature compared to the experimental data [
In Figure 4, it can be seen that Kaptay’s model [7] well the experimental data well for the viscosity of molten magnesium as a function of temperature [38, 39, 40].
\nCalculated viscosities of the pure molten Mg as a function of temperature compared to the experimental data.
In Figures 5, 6, 7, 8, the surface tension for pure Al, Cu, Si, and Mg is depicted as a function of temperature, calculated from surface tension-viscosity relations according to Egry [34] and Kaptay [7] formulations. For all cases, except for Si in Figure 7, the surface tension exhibits a trend to decrease as the temperature increases. It also can be noticed that for all cases, they diverge close to the melting point. For high temperatures, both models yield very close results. The best agreement observed between the two models is that of pure Mg, as shown in Figure 8.
\nComparison between surface tension of pure molten Al as a function of temperature provided by both Egry’s and Kaptay’s surface tension-viscosity relation models.
Comparison between surface tension of pure molten Cu as a function of temperature provided by both Egry’s and Kaptay’s surface tension-viscosity relation models.
Comparison between surface tension of pure molten Si as a function of temperature provided by both Egry’s and Kaptay’s surface tension-viscosity relation models.
Comparison between surface tension of pure molten Mg as a function of temperature provided by both Egry’s and Kaptay’s surface tension-viscosity relation models.
Figures 9, 10, 11, 12 show the evolution of viscosity as a function of temperature for all examined alloys, where it can be seen that the two models generally exhibit similar results. The greatest deviation between the models can be observed for the Al-6wt%Cu-3wt%Si alloy, Figure 10; but even in this case, a relatively good agreement can be considered. This may be related to the non-ideal term of viscosity of the Redlich-Kister equation, whose coefficients do not depend on the alloy composition but depend on the temperature [36].
\nSimulations of viscosity of Al-6wt%Cu-1wt%Si as function of temperature: Arrhenius-type equation and Kaptay model.
Simulations of viscosity of Al-6wt%Cu-3wt%Si as function of temperature: Arrhenius-type equation and Kaptay model.
Simulations of viscosity of Al-6wt%Si-3wt%Cu as function of temperature: Arrhenius-type equation and Kaptay model.
Simulations of viscosity of Al-6wt%Si-3wt%Cu as function of temperature: Arrhenius-type equation and Kaptay model.
Figure 13 shows the application of the derived surface tension relation equation for alloys, Eq. (13), to ternary Al-Cu-Si and quaternary Al-Cu-Si-Mg alloys. As can be noticed, the increase in the alloy Si content decreases the surface tension. The lowest surface tension profile is associated with the alloy having the highest Si content, that is, for the Al-12wt%Si-1wt%Cu-1wt%Mg quaternary alloy.
\nApplication of derived surface tension-viscosity relation for Al-Cu-Si ternary alloys and quaternary Al-Cu-Si-Mg alloys as function of temperature.
A solution for viscosity of alloys has been derived based on an extension of Egry’s surface tension-viscosity relation equation for pure metals [34] and Kaptay’s [10] unified solution for viscosity of multicomponent alloys. Kaptay and Egry’s surface tension-viscosity relations were plotted against temperature. It was shown that for the pure metals analyzed in the present study, for lower temperatures, both relations deviated from each other. However, for higher temperatures, a better agreement has been achieved. The derived solution for surface tension was plotted against temperature for ternary Al-Cu-Si and Al-Cu-Si-Mg alloys. It was shown that with increasing Si alloy content, the surface tension of Al-based alloys decreases, which is in agreement with the casting practice of Aluminum-based alloys.
\nThe authors acknowledge the financial support provided by FAPERJ (The Scientific Research Foundation of the State of Rio de Janeiro), CAPES, and CNPq (National Council for Scientific and Technological Development).
\nNeuroblastoma is one of the most common solid extracranial tumour in the paediatric age group. Key characteristics of neuroblastoma include onset at an early age, aggressive behaviour, tendency to metastasize, regress spontaneously in infancy, and variable presentation [1, 2]. Neuroblastoma is associated with grim prognosis with 60% of patients at presentation having only 5–15% chance of long term survival [3]. Most of the cases of central nervous system neuroblastoma are due to metastasis from the extracranial site. Primary central nervous system neuroblastoma (PCNS-NB) is uncommon as metastatic intracranial neuroblastoma (MIC-NB). It is essentialto understand that the manifestation of neuroblastoma varies with the site of origin [4, 5]. Therefore, a PCNS-NB has different epidemiology, clinical features, and outcomes compared to the MIC-NB. There is emerging evidence on various molecular and genetic profiling of neuroblastoma which dominates the clinical picture. At the end of this chapter, the readers will acquire updated information on the PCNS-NB, various modes of presentation, and treatment outcomes in light of current evidence. Recent research areas, molecular and genetic findings, and areas with gaps of knowledge are also highlights of this chapter.
Horten, and Rubinstein provided the earliest large scale description of 35 cases of PCNS-NB in 1976 [6]. Their description includes the gross description of the tumour, clinical features and management, but lacks the description of the evolution of these tumours. They described three variants of PCNS-NB based on connective tissue stroma and cells with ganglionic differentiation. The classic variant is similar to the peripheral neuroblastoma with relatively high proportions of cells with ganglionic differentiation and high frequency of Homer Wright rosettes. A desmoplastic variant consists of tumours composed of intense connective tissue stroma. A transitional variant consists of tumours with both classical and desmoplastic features [6]. They found 40% to have metastasis along the craniospinal axis at autopsy and reported PCNS-NB to be similar to cerebellar medulloblastoma [6]. Overall three years survival is reported to be 60% and five years survival at 30% [7]. Most of these studies have probably clubbed other tumour types (Medulloblastoma, undifferentiated ependymoma, and sarcoma) in the expectedstandard category of CNS neuroblastoma; hence, they do not provide a precise analysis of this rare entity. Further, most studies on PCNS-NB have variable reporting on the treatment modalities, surgical options, extent of resection, adjuvant chemoradiation and long term outcomes. Therefore PCNS-NB is still one of the least understood neoplasms of the CNS.
In 2016 WHO classification of CNS tumours, CNS neuroblastoma is classified under neuronal and paraneuronal tumours with ICD 0 code of 9500/3 [8]. The first four digits of the ICD 0 code indicates the specific histologic term and the fifth digit after/indicates the nature of the tumour with 3 indicating malignant behaviour. Primary central nervous system neuroblastoma (PCNS-NB) is defined as an embryonal tumour with poorly differentiated neuroepithelial cells, groups of neurolytic cells and variable neuropil rich stroma [8]. These tumours carrier grave prognosis and usually portrays aggressive behaviour [4]. Ganglioneuroblastoma is a subtype of neuroblastoma and defined by the International Neuroblastoma Pathology Classification framework based on the Shimada system [9, 10].
Neuroblastoma is primarily a neoplastic disease of the peripheral nervous system. Oncologists often describe neuroblastoma as enigmatic heterogenous neoplasia due to its unique features and biological properties of spontaneous regression, aggressive progression and maturation [2, 11, 12]. These variable factors serves as the prognostic factors in the cure and outcome of neuroblastoma [12, 13]. Epidemiology of PCNS-NB differs from the heterogeneous group of neuroblastoma [2]. In general, neuroblastoma is diagnosed most commonly in the first year of life with a median age of diagnosis at 18 months, with 90% of children with neuroblastoma presenting under ten years of age at an estimated prevalence of 25–50 cases per million individuals [14, 15]. However, only cases reports and case series of few patients exist for PCNS-NB. To understand the epidemiology and natural history of PCNS-NB, Lu et al. [16] conducted a population-based study using the SEER (Surveillance, Epidemiology and End Results) program. The annual incidence of PCNS-NB has shown a downward trend from 1973 to 2013, probably because many of these tumours were earlier labelled as medulloblastoma, undifferentiated ependymoma or sarcoma due to inferior diagnostic methods [16]. As per the SEER program, the annual age-adjusted incidence rate was 0.12 per 1,000,000 persons in 2013 and the incidence decreased with age with peak incidence occurring in infants [16, 17]. No gender or racial variation has been reported for the occurrence of PCNS-NB. In the study by Lu et al. [16], 40.7% of patients belonged to the age group 1–9 years and only 8.2% were of age ≥ 40 years. Mean age of patients in reported literature of PCNS-NB is around five years with slight female preponderance.
Histologically most common histology of the PCNS-NB is neuroblastoma, followed by ganglioneuroblastoma. In a large population-based study brain (53.6%) was found to be the most common site of PCNS-NB, followed by other nervous system tumours (46.4%). Tumours at sites in the nervous system other than the brain tend to occur in a much younger age group, extensive and more aggressive [16].
Neuroblastoma arises from the primitive elements of the neural crest and therefore predominantly affects the neural crest derivatives, i.e. adrenals and sympathetic ganglia. The central nervous system (CNS) can be involved in the form of primary CNS neuroblastoma, CNS metastasis secondary to occult primary, primary intraorbital neuroblastoma from the ciliary ganglion, metastatic neuroblastoma to the orbit, primary intraspinal neuroblastoma originating from dorsal root ganglion, metastatic spinal neuroblastoma and remote paraneoplastic effects such as myoclonic encephalopathy. WHO classification of CNS tumours (2007) enlist CNS-PNET-NOS (not otherwise specified) and four variants of CNS PNET which can be differentiated based on molecular characteristics as CNS neuroblastoma, CNS ganglioneuroblastoma, medulloepithelioma and ependymoblastoma [8]. According to the 2016 WHO classification of CNS tumours, CNS neuroblastoma is classified as an embryonal tumour [8]. CNS-PNET was not found to be a separate entity after the DNA methylation profile of most of the PNET tumours. However, when most well-defined CNS tumours with similar DNA methylation profiles were excluded, there were few unknown tumours, one of which is CNS neuroblastoma [18]. This new molecular entity after DNA methylation was designated as “CNS neuroblastoma with
The development of PCNS-NB does not follow two-hit models usually suggested in neuro-oncology. Instead, it results from the persistence of embryonic cell, which should have differentiated or undergone apoptosis during the ordinary course of CNS development. Bcl-2 family of genes regulate apoptosis, and its continued expression appears to play a significant role in the pathogenesis of neuroblastoma and its resistance to chemotherapeutic drugs. Other genetic factors implicated in neuroblastoma development include cytogenetic aberrations in neuro crest development, partial monosomy for the short arm of chromosome 1, and long arms chromosomes 11 and 14. Shimada system of classification of neuroblastoma and International Neuroblastoma Staging System is illustrated in Tables 1 and 2, respectively. There are even reports of neuroblastoma occurring post-radiation in children and adults [19, 20, 21, 22].
Type | Description |
---|---|
Neuroblastoma (Schwannoma stroma-poor) | |
Ganglioneuroblastoma, intermixed (Schwannoma stroma-rich) | |
Ganglioneuroma (Schwannoma stroma-dominant) | |
Ganglioneuroblastoma, nodular (composite schwannoma stroma-rich/stroma-dominant and stroma-poor) | |
NT, unclassifiable |
The international neuroblastoma pathology classification of neuroblastoma (Shimada system) [1].
Stage 1 | Complete gross excision of localised tumour, with or without positive microscopic margins | Negative ipsilateral non-adherent lymph node(s) (lymph node(s) attached to and removed with the primary tumour may be positive) |
Stage 2A | Incomplete gross excision of localised tumour | Negative ipsilateral non-adherent lymph node(s) (lymph node(s) attached to and removed with the primary tumour may be positive) |
Stage 2B | Complete or incomplete gross excision of localised tumour | Positive ipsilateral non-adherent lymph node(s); contralateral lymph node(s) negative for tumour |
Stage 3 |
|
|
Stage 4 | Any primary tumour with involvement of distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs (except 4S) | |
Stage 4S | Any localised primary tumour with involvement of skin, liver, and/or less than 10% of bone marrow cellularity (ONLY applies to children less than 1 year of age) |
Patients usually present with features of intracranial mass lesion and raised intracranial pressure. Secondary neuroblastoma is mainly extra-axial pathology. It presents as a bony lesion involving the calvaria and extradural mass lesion. However, the lesion can produce haemorrhagic deposits in the parenchyma and increase intracranial pressure and altered neurological status. Presentation with seizures is not very common. Extra-axial deposits of neuroblastoma present with neurological deficits due to compression of eloquent brain parenchyma. These lesions can also have sutural diastasis due to epidural deposits along the sutures and do not indicate raised intracranial pressure. The status of venous sinuses should be evaluated with CT and MR imaging in patients with sutural diastasis as increased intracranial pressure will show compression of venous sinuses, which will be absent in sutural diastasis due to neuroblastoma deposits [23]. PCNS-NB being intra-axial pathology presents headaches, vomiting, ill localised features, localising features based on cerebral location, and raised intracranial pressure and seizures. Many of these patients present with clinical features on intraventricular mass lesions and hydrocephalus. There can be sudden worsening in the neurological status in the event of a haemorrhage within the lesion.
A typical CT picture of PCNS-NB shows a large intra-axial lesion with calcifications, cystic degeneration and areas of haemorrhage [24]. Perilesional oedema may be limited as compared to the size of the lesion [24]. On post-contrast CT images, uniform enhancement is seen in solid masses, and heterogeneous contrast enhancement is seen in lesions with cystic degeneration and extensive calcifications. Additionally, intraventricular lesions can demonstrate subependymal masses and help in differentiating these lesion from other differential diagnoses of intraventricular mass lesions. MR imaging of these tumours shows inhomogenous intensities on both T1 and T2-weighted images [24]. Areas of calcification and flow voids can be challenging to identify in classical MRI and can be seen well in susceptibility-weighted images (SWI). Different duration of haemorrhage within the lesion can be appreciated well on MR images. On gadolinium-enhanced T1-weighted MR imaging, tumour mass shows inhomogeneous contrast enhancement. Contrast MRI further helps in identifying subependymal enhancement, recurrence around previously operated sites and leptomeningeal spread. Imaging also helps to assess ventricular size as these tumours grow towards the ventricles and many patients develop secondary hydrocephalus. As there are no pathognomonic image findings of PCNS-NB, it should be kept in the differential diagnosis of any patients with the clinical possibility of PCNS-NB and intra-axial, intraventricular or periventricular mass lesion [24]. Primary CNS neuroblastoma is usually intra-axial and spread through CSF pathways, whereas secondary neuroblastoma is mainly extra-axial but can have haemorrhagic deposits in the parenchyma and sutural diastasis on CT due to epidural deposits [23].
Grossly PCNS-NB tumours are massive, discrete, firm, and cystic in appearance. Histopathology of a newly designated group of tumours as CNS neuroblastoma which were earlier designated as CNS neuroblastoma or CNS ganglioneuroblastoma in 2007 WHO classification scheme [8] showed distinct characteristics. CNS NB-FOXR2 showed an embryonal architecture with small cells and areas of differentiation in neuropil, neurocytic cells and ganglion cells with uniform expression of OLIG2 and neuronal antigen synaptophysin (Figure 1) [13, 18]. Histologically ganglioneuroblastoma consists of ganglion cells with different degrees of differentiation, Nerve sheath, glial fibres, and malignant neuroblastoma cells [9, 25, 26, 27]. Common pathological picture of ganglioneuroblastoma includes ganglion cells with a double nucleus, highly infiltrated and proliferated cells with dense chromatin [28, 29]. Further ganglioneuroblastomata have two histological subtypes: undifferentiated type has a small round to oval cells with hyperchromatic nuclei, and poorly differentiated type has a large round to oval spindle-shaped cells with pale staining nuclei [30, 31].
Various routes for entry of neuroblastoma cells, and its spread to and within CNS.
Neuroblastoma is an enigmatic and one of the most common malignant solid tumour of the paediatric age group. Neuroblastoma is a disease with a grim prognosis, and the outcome has not changed significantly in the past two decades. Neuroblastoma teaches us essential aspects of CNS and neural crest development. Primary CNS Neuroblastoma (PCNS-NB) is a rare subtype of neuroblastoma with variable classification. It includes CNS neuroblastoma and ganglioneuroblastoma. In 2016 WHO classification of CNS tumours, PCNS-NB is classified as embryonal tumours. Embryonal tumours with the exception of medulloblastoma has been reclassified based on molecular alterations, for example atypical teratoid rhabdoid tumour (AT/RT) characterised by SMARCB1 or SMARCA4 inactivation, C19MC altered and/or LIN28A expressing embryonal tumour with multi-layered rosettes (ETANTR) and CNS neuroblastoma/Ganglioneuroblastoma without specific histological features or molecular alterations [8]. Based on global transcriptional and methylation profiling four tumour entities have been proposed: CNS neuroblastoma with FOXR2 activation (NB-FOX-R2), High grade neuroepithelial tumour with MN1 alteration (HGNET-MN1), high grade neuroepithelial tumour with BCOR alteration (HGNET-BCOR), and Ewing sarcoma family tumour with CIC alteration (EFT-CIC) [18]. CNS neuroblastoma rarely contains GFAP positive cells which are usually reactive astrocytes and most of the NB-FOX-R2 tumours are neuroblastic differentiation and contains neurocytic cells with poorly differentiated neuropil rich stroma and embryonal architecture [32]. However, there are reports of CNS neuroblastoma with GFAP positive tumour cells demonstrating both neuronal and glial nature, though the clinical significance of such entity is unknown [32]. Since, PCNS-NB is a rare entity and usually present in younger age group, little is known about its treatment protocols, prognostic factors and patient risk stratification. Review of literature suggests that PCNS-NB preferentially occurs in the supratentorial space with involvement of frontal and parietal region [4]. Clinical presentation of PCNS-NB is usually as per the most common site of involvement. Since, most of the PCNS-NB prefers supratentorial location preferably in the frontal and parietal region, patients usually manifest with focal neurological deficits, bony lesions, irritative symptoms in form of seizures and symptoms of raised intracranial pressure due to mass effect. These effects of raised intracranial pressure and mass effect are less pronounced in infancy in younger children because of compensatory and adaptive mechanism of surrounding brain structures. Metastatic presentation of PCNS-NB is reported only in couple of cases via cervical lymph nodes and cerebrospinal fluid [33]. Therefore in evaluation of PCNS-NB complete screening neuroimaging of whole cranio-spinal neuroaxis should be performed to rule out any metastatic spread through the CSF. In general, PCNS-NB appears like other solid CNS tumours in brain MRI. They can be purely solid or solid-cystic. Solid component of tumours are T1 and T2 hypointense with mild hyperintensity on DWI sequences and inhomogenous contrast enhancement and increased relative cerebral blood volume (rCBV) on perfusion images. Cystic component of tumour appears hyperintense due to hyperproteieic content. MRS sequences show increase in choline peak and inversion of choline/NAA ratio, but none of these imaging parameters are unique to the PCNS-NB. It is essential to understand that there are no tumour markers or radiological markers which can reliably differentiate PCNS-NB from other tumours. Two essential criteria for defining PCNS-NB is presence of classical histology and absence of systemic neuroblastoma.
The outcome of PCNS-NB depends on age, the tumour’s aggressiveness, tumour subtype, locations, histology and extension. Surgery is the treatment of choice, and adjuvant radiotherapy improves survival. Safety and outcome of radiotherapy are not well established in infants and younger population but need to be viewed in light of improved survival obtained by adjuvant radiotherapy.
Younger age group, a limited number of lesions, ganglioneuroblastoma subtype and surgical management, are found to be positive prognostic factors in PCNS-NB. Neuroblastoma has complex heterogeneous nature with varied prognosis, infants <1 year of age tend to have maximum overall survival with the tumour spontaneously regressing in some infants on the one hand and having widespread metastasis on the other hand [2, 12]. Studies have found best overall survival in infants <1 year of age and relatively less short term adverse events in age > 40 years with a 1-year survival of 57.2% [16].
In the population-based studies, patients with extensive disease, multiple lesions, and metastasis were more often offered conservative management as surgical excision was not feasible [16]. Surgical excision is often referred to as the first line of management in the treatment of PCNS-NB, whenever feasible [4]. Differentiation in ganglioneuroblastoma lies in between malignant neuroblastoma and benign ganglioneuroma. Ganglioneuroblastoma subtype is found to be associated with a good prognosis. Studies show that the ganglioneuroblastoma subtype rarely infiltrates and tends to be localised with less incidence of metastatic deposits [16, 34]. This explains that patients with this subtype are likely to be offered surgery and benefit from surgical excision with overall better survival. Ganglioneuroblastoma typically has a high invasive behaviour but slower multiplication rate and the asymptomatic period of up to 60 months has been reported after surgical excision [35, 36].
Adjuvant radiotherapy of the primary site is the standard of care in high-risk neuroblastoma patients to reduce the risk of recurrence [6, 37]. Bennett et al. [7] suggested prophylactic irradiation craniospinal axis due to high propensity of CSF metastasis and recurrence of PCNS-NB [6]. However, the role of radiotherapy in PCNS-NB is not well elucidated. This is because the side effects of radiotherapy in the younger age group of radionecrosis and cognitive decline limit its applicability. Lu et al. [16] found a variable practice pattern of adjuvant radiotherapy and reported better survival and no significant side effects of radiotherapy, contrary to other studies.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
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\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
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\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
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\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. 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Martins Ferreira"},{id:"145815",title:"Dr.",name:"Rodrigo",middleName:null,surname:"De Santis Neves",slug:"rodrigo-de-santis-neves",fullName:"Rodrigo De Santis Neves"},{id:"145816",title:"Dr.",name:"Carlos",middleName:null,surname:"Eduardo Cardoso Galhardo",slug:"carlos-eduardo-cardoso-galhardo",fullName:"Carlos Eduardo Cardoso Galhardo"},{id:"159056",title:"Dr.",name:"Jailton",middleName:null,surname:"Damasceno",slug:"jailton-damasceno",fullName:"Jailton Damasceno"},{id:"191863",title:"Dr.",name:"Daniel",middleName:"Pereira Da Silva",surname:"Fernandes",slug:"daniel-fernandes",fullName:"Daniel Fernandes"},{id:"191865",title:"Dr.",name:"Rafael",middleName:null,surname:"Mello Trommer",slug:"rafael-mello-trommer",fullName:"Rafael Mello Trommer"}]},{id:"53946",title:"The Evolution of Quality Concepts and the Related Quality Management",slug:"the-evolution-of-quality-concepts-and-the-related-quality-management",totalDownloads:4438,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"Enterprises usually adopt some quality practices to control the product quality during the manufacturing process in order to assure the delivery of qualitative good products to customers. The quality practices or quality management systems adopted by industries will further evolve due to the changes of quality concepts as time goes by. This chapter discusses the change of quality concepts and the related revolution of quality management systems in the past century. The quality concepts were gradually changed from the achievement of quality standards, satisfaction of customer needs, and expectations to customer delight. Since merely satisfying customers is not enough to ensure customer loyalty, the enterprises gradually focus on customers’ emotional responses and their delight in order to pursue their loyalty. The emotion of “delight” is composed of “joy” and “surprise,” which can be achieved as the customers’ latent requirements are satisfied. Thus, the concept of “customer delight” and the means to provide the innovative quality so as to meet the unsatisfied customers’ latent needs are elaborated on. Finally, a framework of innovation creation is developed that is based on the mining of customer's latent requirements. This outline will manifest the essential elements of the related operation steps.",book:{id:"5486",slug:"quality-control-and-assurance-an-ancient-greek-term-re-mastered",title:"Quality Control and Assurance",fullTitle:"Quality Control and Assurance - An Ancient Greek Term Re-Mastered"},signatures:"Ching-Chow Yang",authors:[{id:"11862",title:"Prof.",name:"Ching-Chow",middleName:null,surname:"Yang",slug:"ching-chow-yang",fullName:"Ching-Chow Yang"}]},{id:"62915",title:"Advanced Methods of PID Controller Tuning for Specified Performance",slug:"advanced-methods-of-pid-controller-tuning-for-specified-performance",totalDownloads:3476,totalCrossrefCites:10,totalDimensionsCites:16,abstract:"This chapter provides a concise survey, classification and historical perspective of practice-oriented methods for designing proportional-integral-derivative (PID) controllers and autotuners showing the persistent demand for PID tuning algorithms that integrate performance requirements into the tuning algorithm. The proposed frequency-domain PID controller design method guarantees closed-loop performance in terms of commonly used time-domain specifications. One of its major benefits is universal applicability for both slow and fast-controlled plants with unknown mathematical model. Special charts called B-parabolas were developed as a practical design tool that enables consistent and systematic shaping of the closed-loop step response with regard to specified performance and dynamics of the uncertain controlled plant.",book:{id:"6323",slug:"pid-control-for-industrial-processes",title:"PID Control for Industrial Processes",fullTitle:"PID Control for Industrial Processes"},signatures:"Štefan Bucz and Alena Kozáková",authors:[{id:"21933",title:"Ms.",name:"Alena",middleName:null,surname:"Kozakova",slug:"alena-kozakova",fullName:"Alena Kozakova"},{id:"213658",title:"Dr.",name:"Štefan",middleName:null,surname:"Bucz",slug:"stefan-bucz",fullName:"Štefan Bucz"}]},{id:"75699",title:"Data Clustering for Fuzzyfier Value Derivation",slug:"data-clustering-for-fuzzyfier-value-derivation",totalDownloads:292,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The fuzzifier value m is improving significant factor for achieving the accuracy of data. Therefore, in this chapter, various clustering method is introduced with the definition of important values for clustering. To adaptively calculate the appropriate purge value of the gap type −2 fuzzy c-means, two fuzzy values m1 and m2 are provided by extracting information from individual data points using a histogram scheme. Most of the clustering in this chapter automatically obtains determination of m1 and m2 values that depended on existent repeated experiments. Also, in order to increase efficiency on deriving valid fuzzifier value, we introduce the Interval type-2 possibilistic fuzzy C-means (IT2PFCM), as one of advanced fuzzy clustering method to classify a fixed pattern. In Efficient IT2PFCM method, proper fuzzifier values for each data is obtained from an algorithm including histogram analysis and Gaussian Curve Fitting method. Using the extracted information form fuzzifier values, two modified fuzzifier value m1 and m2 are determined. These updated fuzzifier values are used to calculated the new membership values. Determining these updated values improve not only the clustering accuracy rate of the measured sensor data, but also can be used without additional procedure such as data labeling. It is also efficient at monitoring numerous sensors, managing and verifying sensor data obtained in real time such as smart cities.",book:{id:"9976",slug:"fuzzy-systems-theory-and-applications",title:"Fuzzy Systems",fullTitle:"Fuzzy Systems - Theory and Applications"},signatures:"JaeHyuk Cho",authors:[{id:"329648",title:"Prof.",name:"JaeHyuk",middleName:null,surname:"Cho",slug:"jaehyuk-cho",fullName:"JaeHyuk Cho"}]},{id:"39778",title:"GPS and the One-Way Speed of Light",slug:"gps-and-the-one-way-speed-of-light",totalDownloads:3478,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2387",slug:"new-approach-of-indoor-and-outdoor-localization-systems",title:"New Approach of Indoor and Outdoor Localization Systems",fullTitle:"New Approach of Indoor and Outdoor Localization Systems"},signatures:"Stephan J.G. Gift",authors:[{id:"141106",title:"Prof.",name:"Stephan",middleName:null,surname:"Gift",slug:"stephan-gift",fullName:"Stephan Gift"}]}],onlineFirstChaptersFilter:{topicId:"115",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"77466",title:"Optimization of Model Predictive Control Weights for Control of Permanent Magnet Synchronous Motor by Using the Multi Objective Bees Algorithm",slug:"optimization-of-model-predictive-control-weights-for-control-of-permanent-magnet-synchronous-motor-b",totalDownloads:141,totalDimensionsCites:0,doi:"10.5772/intechopen.98810",abstract:"In this study, the model predictive control (MPC) method was used within the scope of the control of the permanent magnet synchronous motor (PMSM). The strongest aspect of the MPC, the ability to control multiple components with a single function, is also one of the most difficult parts of its design. The fact that each component of the function has different effects requires assigning different weight coefficients to these components. In this study, the Bees Algorithm (BA) is used to determine the weights. Using the multi-objective function in BA, it has been tried to determine the weights that reduce the current values together with the speed error. Three different PI controllers have been designed to compare the MPC method. The coefficients of one of these are tuned with BA. Good Gain Method and Tyreus-Luyben Method were used in the other two. As a result of experimental studies, it has been observed that MPC can control PMSM more smoothly and accurately than PI controllers, with weights optimized with BA. With MPC, PMSM has been controlled with 15% settling time than other controllers and also with no overshoot.",book:{id:"10778",title:"Model-Based Control Engineering - Recent Design and Implementations for Varied Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10778.jpg"},signatures:"Murat Sahin"},{id:"78164",title:"Use of Discrete-Time Forecast Modeling to Enhance Feedback Control and Physically Unrealizable Feedforward Control with Applications",slug:"use-of-discrete-time-forecast-modeling-to-enhance-feedback-control-and-physically-unrealizable-feedf",totalDownloads:63,totalDimensionsCites:0,doi:"10.5772/intechopen.99340",abstract:"When the manipulated variable (MV) has significantly large time delay in changing the control variable (CV), use of the currently measured CV in the feedback error can result in very deficient feedback control (FBC). However, control strategies that use forecast modeling to estimate future CV values and use them in the feedback error have the potential to control as well as a feedback controller with no MV deadtime using the measured value of CV. This work evaluates and compares FBC algorithms using discrete-time forecast modeling when MV has a large deadtime. When a feedforward control (FFC) law results in a physically unrealizable (PU) controller, the common approach is to use approximations to obtain a physically realizable feedforward controller. Using a discrete-time forecast modeling method, this work demonstrates an effective approach for PU FFC. The Smith Predictor is a popular control strategy when CV has measurement deadtime but not MV deadtime. The work demonstrates equivalency of this discrete-time forecast modeling approach to the Smith Predictor FBC approach. Thus, this work demonstrates effectiveness of the discrete-time forecast modeling approach for FBC with MV or DV deadtime and PU FFC.",book:{id:"10778",title:"Model-Based Control Engineering - Recent Design and Implementations for Varied Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10778.jpg"},signatures:"Derrick K. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. 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Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. 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