The pollinators and the pollination rates of ‘0900 Ziraat’ (S3-S12).
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6117",leadTitle:null,fullTitle:"Tools in Artificial Intelligence",title:"Tools in Artificial Intelligence",subtitle:null,reviewType:"peer-reviewed",abstract:"This book offers in 27 chapters a collection of all the technical aspects of specifying, developing, and evaluating the theoretical underpinnings and applied mechanisms of AI tools. 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Regarding its structure and infection mechanism, SARS-CoV-2 is mostly similar to familiar coronaviruses such as the SARS-CoV-1 and Middle East respiratory syndrome (MERS) [2, 3]. Identified in Wuhan, China, it has abruptly spread all over the world with more than 164.513.450 reported cases to date [4]. The respiratory system is the most common target of infection however, various experimental studies and case reports have shown an affinity for neural tissues. Considering observational studies, SARS-CoV-2 patients were registered with complaints of headache, nausea, vomiting, dizziness, myalgia, hypogeusia, hyposmia, and impaired consciousness, all symptoms that indicate involvement of the nervous system [5]. Even though, the exact mechanism which SARS-CoV-2 penetrates the central nervous system has not yet been determined, prior experimental models have shown that other coronaviruses can compromise the nervous system and respiratory drive by directly targeting neurons located in cardiorespiratory centers [6], due to the preliminary observation of cases concerning the COVID-19 pandemic, suggesting a higher affinity of SARS-CoV-2 virus for CNS targets.
The aim of this chapter is to present all of the reported neurological manifestations in COVID-19 with the explanation of possible underlying pathways.
In the previous months, reports of meningitis, encephalitis, myelitis, or peripheral nerve affection in regard to COVID-19 infection were presented, implying that SARS-CoV-2 can directly infect the nervous system.
The SARS-CoV-2 spike protein (S) can bind to the host cellular angiotensin-converting enzyme 2 (ACE-2) receptor because of its high binding affinity, which is of importance to cell tropism [7]. Preparing and processing of the S protein by the transmembrane protease serine 2 (TMPRSS2) have been demonstrated to be crucial for the synthesis of viral and host cellular membranes, furthermore entrance of SARS-CoV-2 [8]. The increased expression of the ACE-2 receptor has been found on neurons and glial cells of several brain structures including the cerebral cortex, the striatum, the posterior hypothalamic area, the substantia nigra, and brain stem. ACE-2 is strongly expressed in the ventrolateral medulla and the nucleus of tractus solitarius, both areas involved in the regulation of the respiratory cycle [9].
Arguably, several mechanisms could be taken into account as possible viral access routes, such as axonal transport and trans-synaptic transfer, and hematogenous or potentially lymphatic system routes. The infiltration of the CNS through the transcribial system describes an infection of the olfactory epithelium continuing transmission through the cribriform plate to the subarachnoid space. On the other side, the axonal and trans-synaptic transport would combine numerous peripheral nerve terminals which leads to contamination by spreading onward neurons (olfactory bulb, the trigeminal nerve, the vagus nerve, etc.) [10].
Another way of CNS infiltration could be through the circulatory system or on the other hand, the lymphatic system routes. Transfer over the brain endothelium could be accomplished through abluminal virus release into the CNS parenchyma, by direct infection of brain microvascular endothelial cells (BMEC), or via endocytosis, through virally affected leukocytes or disrupted tight junctions on BMEC-s [11].
However, direct contamination of cells is not the only way of virus transmission. Indirect neurotoxicity may be caused by immune system disorders, coagulation disorders, cardiovascular comorbidities, disorders of glucose and lipid metabolism, hypoxic encephalopathy, and/or gastrointestinal disorders.
Other than ACE-2, SARS-CoV-2 may utilize extracellular matrix metalloproteinase inducer also known as basigin (BSG; CD147) and transmembrane glycoprotein neuropilin-1 (NRP1) as receptors. Some enzymes that catalyze proteolysis such as TMPRSS11A/B, cathepsin B and L, and furin (FURIN), have been presented to promote viral cell entry and replication [12].
Dissemination of SARS-CoV-2, in which the virus has an effect on peripheral neurons via active transport, synaptic terminals, and retrograde transport to the neuronal body of the cell, has been hypothesized [13]. Studies have been conducted, explaining the mechanism of trans-synaptic transfer involving the hemagglutinating encephalomyelitis virus strain 67 N (HEV-67 N), which represents the first SARS-CoV-2 strain that was found to infect the porcine cerebrum [14]. Data from human single nuclei RNA-seq databases suggest that vascular endothelial cells may express ACE-2 in the human cerebrum at low levels, however non-canonical SARS-CoV-2 receptors (e.g., BSG/CD147) are displayed in several different brain cell types, making them exposed to the virus [15].
Provided by other viruses of the family Coronaviridae, certain possible routes of entry for SARS-CoV-2 have been established [16].
The olfactory nerve (CN I) is the first and shortest cranial nerve. It is a special visceral afferent nerve, which transmits information relating to smell. The sense of smell is distinguished by olfactory receptors situated within the nasal epithelium. Their axons amass into small bundles of olfactory nerves, which infiltrate small foramina in the cribriform plate of the ethmoid bone and enter the cranial cavity. The absence of the sense of smell is defined as anosmia. A temporary loss of smell can be caused by infection or by local disorders, in contrast, a permanent loss of smell may be caused by head injury or tumors. Infection of the olfactory system is consistent with the observation that loss of smell is a frequent neurological manifestation in COVID-19. Some evidence, demonstrate increased MRI signal in the olfactory cortex during the acute phase of SARS-CoV-2 infection [17]. As represented in the case of other coronaviruses, the virus could be disguised in nerve terminals by endocytic mechanisms, transported retrogradely, and spread trans-synaptically to other regions of the cerebrum [18]. As described before, ACE-2 and TMPRSS2 have been identified in the nasal mucosa, epithelial cells (sustentacular cells), but not olfactory neurons [19]. However, there are some evidences of neuronal involvement.
The blood–brain barrier (BBB) acts as an additional boundary between circulating blood and the extracellular space of the brain. The barrier is highly selective, protecting the brain from toxins, pathogens and even circulating neurotransmitters (e.g. glutamate) that can be potentially damaging to neurons. The BBB is a typical route of entry of blood-borne viruses into the brain. In SARS-CoV-2 infection, dissemination of the virus into the blood has been reported, even though frequencies are extensively ranging (1–41%) [16]. Immunoreactivity of ACE-2 was described in brain vessels of a patient with multiple ischemic infarcts. However, the cellular localization was not resolved. Other receptors, such as NRP1 and BSG, could be another possibility of infection due to their more widely expression in the cerebral vasculature [20]. Nonetheless, SARS-CoV-2 associated cytokines – interleukins (IL-6, IL-1b, IL-17) and tumor necrosis factor (TNF) can potentially damage the BBB, which is another way of virus invasion [21]. In several autopsy studies, a lack of florid cerebrovascular inflammation has been described [22]. Comorbidities, as have oftentimes been seen in COVID-19, such as cardiovascular risk factor or pre-existing neurological diseases, in combinations with activation of cytokines, increase the permeability of BBB [21].
Infected immune cells (monocytes, neutrophils, and T cells) can cause brain infestation through the vasculature, the meninges, and choroid plexus [16]. In a study conducted by Chen et al., 2020, SARS-CoV-2 nucleocapsid protein (NP) immunoreactivity was observed in CD68+ cells in lymphoid organs, while single-cell RNA seq data showed viral RNA in macrophages of COVID-19 patients [23]. However, data about virus proliferation in macrophages are limited due to the unknown mechanisms of virus propagation (phagocytic uptake of virus-infected cells or extracellular virions) [24].
Indirect effects of systemic factors of SARS-CoV-2 can lead to acute and chronic consequences, such as respiratory failure, systemic inflammation, hypercoagulable state and, lethal systemic organ failure.
SARS-CoV-2 has been predominantly detected in pneumocytes and epithelial progenitors, which can lead to potential lung damage, causing massive alveolar damage, inflammatory cell infiltration, edema, microvascular thrombosis, and hemorrhage resulting in severe hypoxia and acute respiratory distress syndrome (ARDS) [25, 26]. The most sensitive brain regions to hypoxia, such as the neocortex, hippocampus, and cerebellum have shown neuronal impairment [27].
The correlation between immunosuppression and disease severity has been established. Most COVID-19 patients have higher circulating levels of IL-6, IL-1b, and TNF, but also additionally IL-2, IL-8, IL-17, G-CSF, GM-CSF, IP10, MCP1, and MIP1a2, and serum levels of IL-6 and TNF leading to cytokine release syndrome [28, 29, 30]. After brain entry through the damaged BBB, certain molecules such as the nuclear protein high mobility group box 1 (HMGB1), could act as pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [31]. This process activates an immune response in pericytes, brain macrophages, and microglia, which express toll-like receptors (TLR) which act as mediators for pro-inflammatory effects of SARS-CoV-2 spike protein on human macrophages through nuclear factor-kB (NF-kB) [32]. In this way, immune response boosts the level of cytokine production which results in impairment of brain function [33].
Another vital element of COVID-19 is significant coagulopathy. The multicenter study has been conducted, suggesting that 88% of patients displayed evidence of a hypercoagulable state. The prothrombin time (PT), activated partial thromboplastin time (aPTT), and complete blood count (CBC) are in the reference range. However, fibrinogen level, and fibrin breakdown products indicative of intravascular thrombosis (D-dimer), are both increased. Coagulopathy may start in the lungs causing endothelial damage, complement activation, activation of the procoagulant effect of IL-6, and neutrophil release of extracellular traps (NETs) that leads to the formation of a clot, resulting in intravascular thrombosis [34].
There are many metabolic and pathological evidence of systematic impairment in different organs (heart, liver, gastrointestinal tract, and endocrine system) [35]. Hypoperfusion of the cerebrum could be impacted by a compromised function of the heart [36]. Many neurological symptoms, for instance, headache, confusion, agitation, can be correlated to systemic metabolic changes including electrolyte disbalance, hormonal dysfunction and accumulation of toxic metabolites [37, 38].
Although, SARS-CoV-2 is primarily causing the insufficient function of the respiratory system, there are overwhelming amounts of evidence implying that neurological complications appear as a serious problem in the ongoing COVID-19 pandemic. In the long-term, COVID-19 could negatively affect the nervous system [39].
Among patients who tested positive on SARS-CoV-2, various neurological irregularities have been described, affecting both the central and peripheral nervous system. Clinical condition and symptoms may vary from mild to severe, regardless of patient clinical status (severe form or asymptomatic infection). According to Helms et al., neurological abnormalities have been displayed in 30% of hospitalized patients, 45% of those with severe respiratory problems, and 85% of those who developed ARDS [40]. Patients with mild or asymptomatic infection were more likely to develop nonspecific neurological irregularity including headache, dizziness, malaise, and loss of sense of smell and taste.
In the review by Leonardi M, Padovani A, McArthur JC (2020) [41], authors have classified the reported neurological findings, into three distinctive categories:
Central (headache, dizziness, impaired consciousness, acute cerebrovascular disease, seizures, and meningitis/encephalitis)
Peripheral (hypogeusia, hyposmia)
Musculoskeletal (ischemic or hemorrhagic stroke)
In general, neurological complications in COVID-19 patients occur within 1 and 14 days, in most cases on average on the 5th day of the incubation period [42].
Headache is one of the most commonly reported neurological symptoms of a systemic viral infection. Although direct mechanisms of this symptom are yet to be discovered, there are some possible causes. High body temperature directly causes activation of several immunoinflammatory mediators (cytokines, glutamate, cyclooxygenase-2/prostaglandin E2 system, and nitric oxide system) and activation of substances that are capable of inducing interleukins (exogenous and endogenous pyrogens). Some of the indirect causes are dehydration, electrolyte disbalance, hypoxia, systemic inflammation, and cytokine release syndrome (CRS). One of the possibilities for developing this symptom could also be direct infection of the nervous system via ACE-2 receptors [43].
Vertigo or dizziness has been described as the most common neurological manifestation of COVID-19. Neurotropism of SARS-CoV-2 causes the virus to invade neural tissue from circulation through capillary endothelium (ACE-2 receptors). Aside from this mechanism, direct invasion, hypoxia, and systemic inflammation play the part in causing this symptom. Approximately 7.0% (2.5% to 21.4%) of the COVID-19 patients were reported to have this symptom.
Combined manifestation of dizziness and headache occurred in 12.1% as has been reported in eight studies, with a total of n=654 patients [44].
As anticipated, severe or critical patients tend to develop impaired consciousness (11.9%) due to hypoxia and cerebrum impairment. In patients with mild or asymptomatic clinical manifestations, the prevalence of this symptom is considerably lower (3.2%). The number of studies taken into account was nine, including n=2890 patients with impaired consciousness [45].
The most common display of cerebrovascular disease is an acute stroke with rapidly evolving symptoms which may include weakness of one side of the face or body, numbness, motor or sensory aphasia, ataxia, visual impairment. Those symptoms could be manifested due to compromised blood supply to the brain and which symptom will develop depends on the compromised area of the cerebrum. Regarding this clinical problem, two cohort studies were conducted. The first study by Mao et al. noted that among 214 hospitalized patients, 6 patients developed acute cerebrovascular manifestation (2.8%) [46]. The second study by Li et al. reported 11 patients with acute ischemic stroke (including a total of 221 COVID-19 patients). It has been shown that developing acute cerebrovascular events is highly correlated with the age of the patients (71.6 ± 15.7 years/52.1 ± 15.3 years) [47].
An epileptic seizure is a “transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain” [48]. There are few reports of acute seizures in SARS-CoV-2 positive patients. The first study regarding this clinical manifestation was noted in a COVID-19 patient, a 24-year-old male with generalized seizures, from Japan [49]. The second publication reported a COVID-19 patient, a 30-year-old female with generalized tonic–clonic seizures, from Iran. In both cases, there was no evidence of previous seizures, prior to hospitalization [50]. Even though these and similar reports may suggest that correlation between seizures and COVID-19 infection exist, there are a relatively low number of reported cases so far, therefore a seizure risk is caused by nonspecific mechanisms (hypoxia, cerebrovascular events, cytokine proliferation, etc.).
By definition, meningitis is inflammation of the meninges, in almost all cases identified by an abnormal number of leukocytes in the cerebrospinal fluid and specific symptoms. The etiology may be noninfectious and associated with a systemic disease, medication, or other pathologic factors. However, most cases of aseptic meningitis are caused by viruses. There have been interpreted few single-case reports, regarding meningitis/encephalitis in correlation with COVID-19. Anyhow, only a few of reported cases tested positive for SARS-CoV-2. The first described case was reported from China, but the amount of clinical evidence was underwhelming [51]. Another case was reported in a SARS-CoV-2 positive patient from Japan, manifested as generalized seizure and pathological cerebral MRI (right lateral ventriculitis and encephalitis mainly on the right mesial temporal lobe and hippocampus) [52]. In other reported cases, patients tested negative for SARS-CoV-2, or even were not tested at all [53].
The presence of taste and smell alterations seems to be a usual clinical manifestation going from 19.4–88% of patients [54]. The specific pathogenesis of these issues has not yet been explained. ACE-2 has been distinguished as the cell receptor for SARS-CoV-2. These receptors are expressed diffusely on the mucous membrane of the entire oral cavity, especially on the tongue and furthermore on the nasal mucosa where it takes part in respiratory inflammatory infections by regulating the level of inflammatory peptides, for example, bradykinin. There have been many reports regarding alteration of the senses of smell and taste. The one particular larger study, including a total of 417 patients with mild to moderate SARS-CoV-2 infection, described smell impairment in 85.6% and taste impairment in 88.8% [55].
Stroke is commonly defined as sudden neurological deficit as a result of infarction or hemorrhage in the central nervous system [56]. This is a traditional definition, which has been updated over time with the fact that the neurological symptoms need to last more than 24 hours or CT and MRI confirmed focal infarction or hemorrhage compatible with the symptoms [57]. The typical subdivision of stroke includes ischemic stroke (infarction of brain, retina, or spinal infarction) and hemorrhagic stroke (intracerebral or subarachnoid hemorrhage) [58]. The cause of ischemic stroke is thromboembolism from the small vessel, larger artery, or the heart [59]. Classification of the hemorrhagic stroke depends on the anatomical location, whereas the most common are supratentorial hemorrhages [60].
There are numerous studies that report acute stroke complicating COVID-19 [61, 62]. The reported incidence of acute stroke in COVID-19 varies from 0.4% to 8.1%, due to the different ethnic and geographical variations: Asia (3.1%), Europe (1.2%) and, North America (1.1%) [63]. The reported incidence of stroke in COVID-19 patients treated in the intensive care units (ICU) is 1–3% [64, 65, 66, 67, 68]. Given the extent of the COVID-19 pandemic, this reported incidence is very high. Hemorrhagic stroke has been described from 21.7% to 25.7% COVID-19 patients with stroke, while the rest were ischemic strokes [69].
It has been stated that male COVID-19 patients, the median age of 63 years, are more likely to experience a stroke than women, but it is also known that the majority of ICU COVID-19 patients are older men as well [67]. Other reported risk factors include hypertension, diabetes mellitus [66, 70]. Race/ethnicity is also an important risk factor and it was observed that the black race had shown the highest prevalence (47%) [71]. A severe type of COVID-19 infection was observed as one of the most important risk factors for stroke in these patients [72, 73, 74, 75, 76]. There is a causal relationship between COVID-19 and stroke since the infection itself is more likely to induce thrombotic vascular events [63].
Described mechanisms of stroke in COVID-19 patients are diverse and multifactorial, considering that COVID-19 could be a trigger to typical stroke mechanisms, or alternatively, there are specific pathophysiological mechanisms [63]. The mechanisms for ischemic stroke in COVID-19 include sepsis-induced coagulopathy, presence of antiphospholipid antibodies, and thromboembolism, which show activated coagulation pathway in patients with COVID-19 who ordinarily already have elevated D-dimer and fibrinogen [77, 78, 79, 80, 81]. It is well known that COVID-19 uses the ACE-2 receptor to enter the cells, which leads to increased sympathetic activity, loss of blood pressure auto-regulation, and subsequent cerebral hypoperfusion [82]. Cytokine storm has also been suggested as one of the mechanisms in stroke development in COVID-19, due to its impact on atherosclerosis and thrombosis [83]. Finally, hypoxemia in COVID-19 patients may cause cerebral hypoperfusion and increase the risk of ischemia, together with previously explained thromboembolic mechanisms [84, 85].
Hemorrhagic strokes are less prevalent than ischemic strokes, but it has been implicated that some mechanism which plays a role in ischemic stroke, could lead to intracerebral hemorrhage in COVID-19 [86]. The proposed mechanisms include viral damage of vessel wall, downregulation of RAS and hypertension, cytokine destruction of blood–brain barrier, consumption coagulopathy caused by COVID-19 and cerebral hypoxia which induces micro-hemorrhages and microbleeds [87, 88]. It has been reported that COVID-19 patients who develop stroke are distinctly susceptible to large vessel occlusion, multi-territorial involvement and engagement of else ways infrequently affected vessels such as pericallosal artery [66, 68, 89].
Neuroimaging of stroke in COVID-19 patients standardly includes CT, MRI, and CT angiography (CTA). Small vessel occlusion in acute ischemic stroke was reported in 9% of cases, while large vessel infarctions were seen in almost 65% of cases [67, 68, 71, 90]. More frequent were ischemic strokes in posterior circulation [91]. It has been demonstrated that CTA verified occlusion in anterior or medial cerebral arteries with the co-development of floating thrombi in aorta and carotid arteries in patients with high D-dimer values, which confirms the influence of hypercoagulable state [71, 92]. Apart from standardly seen ischemic lesions, a small number of the patients (two of them were children) with acute stroke had: vasculitis or wall enhancement on MRI in the arterial wall [93]. Imaging findings of the hemorrhagic stroke include extensive hemispheric hematomas or multiple hematomas [94, 95, 96, 97]. Hemorrhages may develop in severely ill patients, especially due to the failure of multiple organs or as a transformation of ischemic stroke, aneurysm rupture, or thrombosis of central venous sinus [66, 97, 98]. Some authors report a possible correlation between COVID-19 and arterial dissection, seen in the carotid artery, cervical vertebral artery or in posterior inferior cerebellar artery [99, 100].
A very small samples of patients were presented with acute stroke confirmed on neuroimaging and PCR confirmed COVID-19 [101]. Described atypical neuroimaging findings are seen in small number of COVID-19 patients with stroke and consist of: brain perfusion abnormalities, leptomeningeal enhancement [eight patients], focal cortico-pial enhancement in one patient, posterior reversible encephalopathy syndrome, microbleeds or leuco-encephalopathy [66, 102, 103]. Atypical findings express latent thrombotic angiopathy, vascular disruption and impairment of vascular autoregulation of the brain which happens in COVID-19 patients with stroke [103, 104].
Even though the COVID-19 virus is primarily a respiratory infection, new reported cases of neurological involvement have been presented daily all over the world [105]. In this chapter, we portrayed the neurological manifestations and possible pathophysiological mechanisms of SARS-CoV-2 on nervous system [105]. Given the extent of the COVID-19 pandemic, it is important to monitor COVID-19 patients for potential neurological complications to provide them with timely diagnostics and treatment.
The authors declare no conflict of interest.
The origin of the cherry (
Cherries grow large trees up to 15 m in height upright and scattered, the branches are smooth, the growth tips are sticky when the leaves open. The flowers form white double or triple bunches. The fruits are in different shapes and colors and the core is semiadherent to the flesh. The fruit is colorless in some cultivars and very dark red in some cultivars [1, 2].
Cultivation of cherry is naturally and wildly grown on the slopes and river valleys of the North Anatolian Mountains, Western and Central Taurus Mountains and at the 1000–1500 m elevations of the Mediterranean side of Eastern Taurus Mountains with very good quality cherries. However, rainfall during the flowering period negatively affects fertilization by preventing bee flight. Also, excessive and long-lasting rainfall at harvest time of ‘0900 Ziraat’ cherry cultivar causes cracking and decreases the cherry production. For this purpose, cracking resistant cultivars have been introduced with TÜBİTAK (The Scientific and Technological Research Council of Turkey) and DPT (State Planning Organization) supported projects which were carried out at the Pozantı Agricultural Research and Application Center of the University of Çukurova. As a result of these experiments, ‘Regina’ and ‘Kordia’ cherry cultivars were determined to be resistant to cracking, and grown and exported besides ‘0900 Ziraat’ national cultivar and ‘Sweetheart’ and ‘Lapins’ self fertile cultivars.
“Turkey’s National Sweet Cherry-Sour Cherry Working Group” was founded in 1997, under the leadership of Prof. Dr. Dr. Nurettin Kaska. Later on, T.C. The General Directorate of Agricultural Research and Policies (TAGEM) of the Ministry of Agriculture and Forestry undertook this organization. All the problems and solutions related to national cherry production were discussed in these working group meetings held 22 times so far and shared with the stakeholders.
Cherry production of Turkey has increased to 732.000 tons in 2020 from 215.000 tons in 1997. Turkey usually exceeded the estimates of the cherry marketers. However, considering the exportation, Turkey ranks third or fourth and most of the exportation has been traditionally performed to Russia and the European Union. Fruit prices in the world cherry market rise to the highest levels both in the early season in April and late season in August. Among world cherry producer countries, USA, Chile and Turkey take the first three places in exportation. Turkey’s cherry exportation in 2020 was 87.944 tons and ranked 4th in cherry exports. This is because Austria and Hong Kong (China) play an important role in the cherry trade, although they do not have a say in cherry production. Although cherry ranks 4th, it is the most valuable crop in our exports in terms of income.
The first trial in Turkey on cherry cultivar adaptation experiments was carried out in Yalova Atatürk Horticultural Central Research Institute on “Selection of local and foreign sweet cherry and sour cherry cultivars” by Dr. Fahrettin Oz. In this study, 51 sweet cherries, 7 sour cherries and 1 sweet cherry-sour cherry hybrid of domestic and foreign cultivars were selected in 1974 and 1975 for their fruit quality characteristics. Yalova Horticultural Central Research Institute carried out cherry adaptation trials in different parts of Turkey from 1982. With these studies ‘0900 Ziraat’ major sweet cherry cultivar and pollinators (‘Lambert’, ‘Bigarreau Gaucher’ and ‘Starks Gold’) became popular.
S alleles of ‘0900 Ziraat’cultivar are S3/S12. Another German cherry cultivar with the same S allele is Nordwunder (Schneiders Späte Knorpel), ‘Princess’ (Prinzesskirsche) and in Italian cherry cultivar ‘Ferrovia’. Therefore, there are various opinions that these two cultivars are the same. The cherry cultivar ‘Schneiders Späte Knorpel’ was discovered in 1850 in Guben, Germany, by co-producer Schneider. Today, it is still one of the most produced cherry cultivars in Germany. Another cherry cultivar found in Guben is ‘Noir de Guben’. This cultivar is produced in our country under the names of ‘Kemalpaşa Napoleon’ in Kemalpaşa, ‘Erkenci Napoleon’ in Bursa and ‘0900 Ziraat’ was also grown under the name of ‘Napoleon’ [3, 4, 5, 6].
Although ‘0900 Ziraat’ national sweet cherry cultivar has a high fruit quality such as resistance for transportation, long shelf life, good fruit flesh firmness, very good taste and aroma, it has also some inadequate features such as low yield caused by the rainfall during the pollination period. Many studies on these problems and similar issues on cherries have been carried out in the Faculty of Agriculture of the University of Cukurova. These studies include; adaptation of cherry cultivars to subtropical conditions [7, 8]; ‘Aksehir Napolyonu’ cherry cultivar packaging and storage in a modified atmosphere, developments on pre-cooling and cold transportation of cherries [9]; clonal micro propagation of clonal cherry rootstocks, investigations on new cherry cultivars adaptable to cold regions of our country, classification of cherry (
Another project was carried out during 1995–1996 by Dr. Nurettin Kaska and his colleagues at Ulukışla and Pozantı villages to increase the economic levels of export-oriented cherry growing potential by modern methods’. With this project, the first pruning was applied on cherry trees.
Newly introduced foreign and local cherry cultivars were used in this project such as Regina’, ‘Venüs’, ‘Summit’, ‘Lapins’, ‘Na-478′, ‘Na-474′, ‘Noir de Guben’, ‘Van’, ‘Larian’, ‘Akşehir Napoleon’, ‘Starks Gold’, ‘Octavia’, ‘Bigarreau Gaucher’, ‘0900 Ziraat’, ‘New Star’, ‘Durono-3′, ‘Tardie de Vignola’, ‘Na-1(Nafrina)’, ‘Early Burlat’, ‘Van Compact’, ‘Bing Spur’, ‘Sunburst’, ‘Fercer Arciana’, ‘Meckenheimer’, ‘Hedelfingen’, ‘Nadino’, ‘E. Rivers’, ‘Kordia’, ‘Precoce de Bernard’, ‘Garnet’, ‘Telegal’, ‘Cristobalina’, ‘Namosa’, ‘Lamida’, ‘New Star’, ‘Prima Giant’, ‘Rainier’, ‘Early Lory’, ‘Big Lory’, ‘Late Lory’, ‘Sweet Heart’, ‘Ferrovia’, ‘Tieton’ and ‘Staccato’ [12].
Orchards were established with these sweet cherry cultivars at different institutes and locations such as Uludağ University Faculty of Agriculture, Yalova Atatürk Horticultural Central Research Institute, Eğirdir Horticultural Research Institute, Malatya Apricot Research Institute, Ordu University Faculty of Agriculture, Çukurova University Faculty of Agriculture and Pozantı Agricultural Research and Application Center. As the result of these studies, ‘Regina’ and ‘Kordia’ cherry cultivars were found to be the best quality cherries in the country [13]. New cultivars were added to those sweet cherry cultivars in Yalova and Eğirdir in 1999 which were ‘Precoce de Bernard’, ‘Techlovan’, ‘Sylvia’, ‘Summit’, ‘N. de Meched’, ‘0900 Ziraat’, ‘Octavia’, ‘Belge’, ‘Sweetheart’, and ‘Regina’. The best results were obtained from ‘Veysel’, ‘Noir de Meched’, ‘Ranier’, ‘0900 Ziraat’, ‘Octavia’, ‘Belge’, ‘Lapins’ ‘0900 Ziraat’ and ‘Sweetheart’ cherry cultivars in Eğirdir and Yalova ecological conditions considering the harvesting time [13].
In a study carried out by Bas et al. [14] on determination of self fertile and exportable cherry cultivars by cross breeding and mutation methods, ‘0900 Ziraat’ and self-fertile ‘Stella’ and ‘Sweetheart’ cultivars were used as parents. Ten of them were taken to the second stage of the selection. Cherry breeding studies have been continued in Yalova and Eğirdir research institutes.
As a result of the experiments carried out at Çukurova University on cherry adaptation in early ripening cherries, these cherry cultivars were detected (end of April-May) ‘Cristobalina’ (self fertile), ‘Prime Giant’ (Pollinators; ‘Brooks’, ‘Lapins’), for mid season cherries, ‘Lapins’ (self fertile), ‘Regina’ (Pollinators; ‘Skeena’ and ‘Durone 3 Nero’ and ‘Kordia’ (Pollinators; ‘Summit’, ‘Skeena’ and ‘Regina for late ripening cherries ‘Sweet Heart’ (self fertile) cherry cultivars were found. ‘Regina’ and ‘Kordia’, resistant cultivars to fruit cracking and ‘Sweetheart’, late season cultivar were found to be suitable for exportation. The very early cherry cultivar ‘Cristobalina’ was found to be more suitable for the domestic market.
Cherry trees usually form a pyramid-shaped crown that rises up to 20–25 m. The trunk of the trees is upright and smooth, and the trunk is grayish-black or dull black with transverse stripes. Cherry branches are smooth, internodes are long in standard cultivars. Flower buds generally begin to form bouquet flowers at the bottom of the branches in the 2nd year. The buds form two types of buds as wooden buds and fruit buds. Wooden buds are thinner and smaller than fruit buds. Fruit buds are large and plump, and they are found in the twigs as side buds. In bouquet branches, there is a shoot bud in the middle and 5–6 fruit buds around it. In fruit buds, the flowers are not one by one, but many. The number of flowers also increases up to 6. The flowers have 5 sepals and 5 petals and up to 30 stamens. Flowers normally have one pistil. Some cultivars have double pistils. The formation of multiple pistils is related to climatic conditions as well as a kind of feature. During flower bud formation in summer, high air temperatures increase the number of double pistil flowers. Multiple pistil flowers reduce the market value of the fruits as they cause twin fruit formation [15].
In terms of fertilization biology of cherries, self incompatibility and cross incompatibility may occur so this situation should be taken into account in orchard plantations [16, 17]. Most of the local cherry cultivars grown in the Marmara Region were found to be self incompatible. Thus, ‘Starks Gold’, ‘Bigarreau Gaucher’, Merton Late’ and ‘Lambert’ cultivars are recommended as pollinators for our important export cultivar ‘0900 Ziraat’. The reason for the low yield of ‘0900 Ziraat’ sweet cherry cultivar was found to be the unfavorable weather conditions during the pollination and fertilization period [18]. As a result of these studies in 2017, the pollinators for ‘0900 Ziraat’ were determined and given in Table 1. According to the results, the best pollination in ‘0900 Ziraat’ cherry cultivar was obtained with ‘Merton Late’. However, Stark’s Gold, Lambert and Bigarreau Gaucher could only pollinate ‘0900 Ziraat’ 50% even if the flowering times coincide. In this case, the reason for the low yield of ‘0900 Ziraat’ in 2017 was the use of ‘Stark’s Gold’ cherry cultivar in most of the cherry orchards which have only 50% of pollination ability (Figure 1 and Table 1). When the unsuitable weather conditions were also considered, the yield was very low.
Self incompatible
50% pollination
100% pollination
Pollinators | S allelles | Pollination rates (%) |
---|---|---|
Starks Gold | S3S6 | 50 |
Bigarreau Gaucher | S3S5 | 50 |
Merton Late | S1S4 | 100 |
Lambert | S3S4 | 50 |
The pollinators and the pollination rates of ‘0900 Ziraat’ (S3-S12).
The pollination ability of similar and different alleles. a. Sterile. b. 50% pollen sterile. c. 100% pollen fertile.
Many nurseries recommend ‘0900 Ziraat’, ‘Regina’, ‘Sweet Heart’ and ‘Kordia’ cherry cultivars to establish cherry orchards. Self fertility, flowering periods and pollination ability of cherry cultivars in nurseries and in orchard plantations should be taken into account (Table 2).
Cultivars | Flowering periods | S alleles |
---|---|---|
Prime Giant | Mid early | S1S9 |
‘Lapins’ | Early | S1S4 (Self-fertile) |
‘Brooks’ | Mid early | S1S9 |
‘Burlat’ | Mid early | S3S9 |
‘Regina’ | Late | S1S3 |
‘Kordia’ | Mid late | S3S6 |
‘Sweetheart’ | Mid late-late | S3S4 (Self-fertile) |
‘Rainier’ | Early | S1S4 |
‘0900 Ziraat’ | Mid season | S3S12 |
‘Ferrovia’ | Mid season | S3S12 |
‘Staccato’ | Mid season | S3S4 (Self-fertile) |
Flowering periods and S-alleles of some important cherry cultivars.
On the other hand, cherry orchards are also established with self fertile cultivars. In this case, although the cultivars are self fertile, bee activity and little windy weather are needed in the orchards for a better pollination at the flowering period. There is no bee activity at temperatures below 10°C and above 38°C. Generally, bee flights are very low at temperatures below 12–14°C. Also, in heavy windy, rainy and cloudy weather bee flight is very weak. For this reason, wild bees are used for fertilization in cold and rainy climates. For this purpose, bee hotels are made or bunches of reeds at different diameters hang on the row of cherry trees.
Thousands of wild bees can fly in unsuitable weather conditions where honey bees can not fly and provide fertilization. Each alone female makes her own nest and finds food for herself and her offspring. Ninety percent of wild bee species live alone. Seventy percent of the 20,000 bee species in the world live underground. Therefore, to keep the bee nests intact, covered soil tillage is becoming forward in cherry orchards.
0900 Ziraat cultivar S alleles are S3/S12. Another cultivar with the same S alleles is the German cherry cultivar Nordwunder (‘Schneiders Späte Knorpel). Therefore, there are various opinions that these two cultivars are the same. The cherry cultivar ‘Schneiders Späte Knorpel’ was found by the producer Schneider on the banks of the Neisse River in Guben, Germany, as a random seed in 1850. This cultivar was recommended and planted everywhere from the early 19th century until the 1960s as the queen of cherries sprung from Guben city, the cherry growing center in Germany. Today, it is still one of the most produced cherry cultivars in Germany. Other cultivars with the same S alleles (S3/S12) are Ferrovia grown in Italy and Princess (Prinzesskirsche) in Germany.
In our country, cherries grow naturally between Artvin and Kocaeli in North Anatolia and Taurus Mountains in the south. Culture cherries are also concentrated on the slopes and river valleys of these mountains at an altitude of 1000–1500 m. However, in recent years, with appropriate rootstock and cultivar selection, the growing areas have spread to lower regions such as Bursa, Iznik, Çanakkale, Izmir (Kemal Paşa) and Manisa in the Aegean region.
Cherry is a high chilling requiring species. The chilling requirements of the cherry cultivars grown in our country are between 500 and 1500 h. Winter cooling is necessary to break dormancy and continue the development in spring. If this requirement is not satisfied, irregular flowering and flower drops are seen. In this regard, approximately 1000 m altitudes are ideal regions for cherries. Cherry trees can damage at low temperatures below −20 and − 24°C. One of the most important factors limiting cherry cultivation is late spring frosts. The flower buds usually die at −4°C, although it also depends on some other factors. Opened flowers are damaged at −2°C. Extreme summer temperatures are undesirable because it promotes double pistil formation and twin fruits and such fruits have no market value.
Cherries are propagated by budding and grafting on several rootstocks. In Turkey, cherries and sour cherries are generally propagated by dormant budding. Although, this budding period varies according to the climatic conditions, it is mostly carried out between July and September, usually by classical “T” budding method.
In subtropical climatic conditions with a long vegetation period, the most suitable budding period is the spring budding period in February-March. Budsticks can be taken directly from the trees for chip budding. There are negative points for classical “T” budding at spring growth season in April. First of all, it is necessary to wait for the removal of the bark of the rootstocks and the budsticks have to be kept at low temperatures until mid-April for the most suitable period for budding. In April buddings, the bud union may be delayed, the growth season shortens and the seedling quality may decrease. For this reason, the most suitable propagation period for cherries and sour cherries is in winter with chip budding under controlled or outdoor budding conditions.
The natural growth habit of cherry trees is upright and vigorous, forms very high trees. The formation of large trees also affects the planting distances and the cherry orchards are planted at intervals of 7 × 7–8 × 8 m, even 10 × 10 m. The height of them should be reduced by using dwarf rootstocks. Recently, dwarf rootstocks, spur and compact cultivars have been used in modern fruit growing. In traditional cherry cultivation in our country, medium strong
Today, cherry production in many European countries is declining in favor of pome fruits. The reasons for this are; very high forms of the trees, difficulty in mechanization, high labor costs in harvest and in other cultural techniques. Tree heights can be kept at 3.5–4 m by using dwarf rootstocks with low crown. Planting intervals can be reduced from 9 × 7 or 8 × 6 m to 5 × 5, 5 × 2.5 and 4 × 1.6 m.
Belgium: Three commonly used rootstocks; Inmil (G.M.9), Damil (G.M.61) and Camil (G.M.79). Germany: 12 rootstocks under the name of Gisela were obtained during the hybridization studies of cherry rootstocks in Giessen. Apart from Germany, these rootstocks have started to spread in Europe and America. 5 sour cherry selection was obtained from the rootstock in M. Freising Weihestephan University. These are W-10, W-13, W-53, W-72 and Weiroot 158. In the hybrid studies conducted by H. Fisher at the Pillnitz Research Institute in Dresden, PiKu 422 and Pi-Ku 483 rootstocks were obtained. Italy: CAP rootstocks were obtained by selection from cherries at the University of Bologna. USA: MM series or MaxMa rootstocks were obtained from
Tree form | Rootstocks | Planting distances (m) | Tree per/ha |
---|---|---|---|
Spindel | Maxma14 | 4.5 × 3.5 | 593 |
Spindel | Gisela 6 | 4.5 × 2.5 | 831 |
Drapeau | Maxma14 | 4.5 × 3.5 | 593 |
Drapeau | Gisela 6 | 4.5 × 2.5 | 831 |
Bush | Maxma14 | 5 × 3.5 | 534 |
Bush | Gisela 6 | 5 × 2.5 | 748 |
Mikado | Maxma14 | 5 × 2.5 | 748 (4 main branches) |
Drilling | Gisela 6 | 5 × 2 | 935 (4 main branches) |
Different training, planting distances and number of trees per hectare in Turkey.
Another problem in cherry seedling production is the inoculation of cultivars suitable for rootstocks. This problem was encountered on Giesela rootstocks. In the orchards established with self fertile Sweetheart and Lapins cherry cultivars on dwarf Giesela-5, the fruit size did not reach the export size due to excessive fruit set.
No pruning was applied on cherry trees before 1996 in Turkey except cutting dry branches. In a cherry meeting with cherry growers and technicians in Pozanti Agricultural Research and Application Center, under the leadership of Prof. Dr. Nurettin Kaşka in 1996, Prof. Dr. Ali Küden [19] gave a seminar and a training course on pruning and showed pruning applications on cherry trees at the orchard conditions at the first time in the country. After this activity, several pruning seminars and applications were held in cherry regions, such as training of 30 Agricultural Engineers from various institutes of the Ministry of Agriculture in Pozanti Center. In this way, new cherry cultivars and new pruning methods of cherries were spread in important cherry production regions.
The experimental cherry trees established at Pozantı Agricultural Research and Application Center were given a different upright branching shape and pruning was done in the following years. As in other fruits, pruning in cherries can be divided into three groups which were: training, yield pruning and rejuvenation pruning. Generally, the training shapes given to cherry trees were; Modified Leader, Spindel, Super Spindel, Super Spindel Ax, Solax, V system, bush, KGB, Spanish bush system, Fan, Upright Fruiting Offshoots (UFO), Drapeau and Bibaum. Recently, the Super Spindel Ax and UFO in USA, the Fruit Wall system in France and the 3-branch Fruit Wall system in Italy are getting popular.
These pruning forms have been developed in different countries by considering their soil and climatic conditions such as humidity, lightening and common cherry diseases and economical causes. In Belgium, compared the classical system, the British system, the Spanish bush system, the V-system and the UFO-systems in the European project on ‘Kordia’ and ‘Sweetheart’ cherry cultivars grafted on Gisela-5 rootstock. At the end of this study, the classical system was found to be the best in terms of efficiency and quality [20].
According to the rootstocks, pruning and planting systems were changed in cherries, for early fruit set, dwarf rootstocks came forward. In another study carried out at Çukurova University to get early fruit set from the cherries grafted on semi-dwarf and strong rootstocks, short cuts in winter pruning (Figure 2) and shoot breaking method.
In winter pruning, with short cuts of 5-15 cm in annual shoots fruit set in the same summer and the second summer fruit production.
In a study carried out in Ulukışla, short cuts of 5–10–15 cm in winter were applied to 1–2 years old branches of ‘Lapins’, ‘Summit’, ‘Sweetheart’ and ‘0900 Ziraat’ cultivars grafted on
Nitrogen contents of the branches were found to be higher in the uncut branches and lower in the cut branches. On the cut shoots, fruit bouquet, called the 1st summer may bouquet, was formed, and immediately the second summer fruit was taken. In this case, the branches should be cut and discarded in the shape of the pruning and short cuts caused early fruit set. At the end of this research, short cutting was accepted to be a good method to break juvenility period [21].
The shoot tips of cherries get too much nitrogen. When the shoots are cut, nitrogen uptake decreases and carbohydrate (Ch) accumulation increases (Table 4). According to these results, in winter pruning, 1–2 years old shoots are cut from 40 to 50 cm in standard cultivars and from 25 to 30 cm in self-fertile cultivars. As a result of this study, shortening the juvenility period of the young cherry trees by shoot cutting was determined to be possible (Figure 3).
Cultivars | Control (no pruning) | 5 cm cut | 10 cm cut | 15 cm cut | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fruit bud | CH (%) | N (%) | Fruit bud | CH (%) | N (%) | Fruit bud | CH (%) | N (%) | Fuit bud | CH (%) | N (%) | |
Sweet Heart | — | 9.3 | 0.86 | 3 | 9.6 | 0.53 | 4 | 10.7 | 0.75 | 5 | 16.7 | 0.80 |
Lapins | — | 5.0 | 0.82 | 8 | 11.5 | 0.43 | 2 | 11.1 | 0.68 | 6 | 6.3 | 0.52 |
Summit | — | 8.1 | 1.07 | 7 | 9.0 | 0.69 | 6 | 4.9 | 0.71 | 5 | 14.5 | 0.75 |
0900 Ziraat | — | 3.2 | 0.85 | 10 | 6.9 | 0.48 | 11 | 6.5 | 0.37 | 8 | 14.4 | 0.52 |
The effect of different short cuttings of the shoots on the nitrogen and carbohydrate accumulation.
In winter pruning, with short cuts of 20–25 cm in annual shoots fruit set in the same summer and the second summer fruit production.
Dwarf rootstocks in cherries as well as expanding branch angles, hanging various weights and semi horizontal planting accelerates the formation of fruit buds. However, the branch breaking method previously applied in apples, also gives very positive results in cherries (Figure 3).
In the branch breaking method, ¼ of the branches are cut from the top and the branches are half broken. As a result, fruit buds are formed in the broken branches in 1–2 years (Figures 4 and 5).
Tying the broken branches after winter pruning, formation of flower buds, flowering and fruit set.
Tying the broken branches, this application is done in February – March.
In cherry trees, 40–60 cm cuts are made in the whole crown according to the development of the shoots from outside to inside. In cherry trees, especially the injured and cut areas are the entry points of the bacteria that cause branch cancer, cutting thick branches in winter pruning increases the risk of branch cancer in the trees.
Bacteria, which are branch cancer agents and cause gluing at these points, are rarely found in nature, especially in August. For this reason, shape prunings should be done in early July, and thick branches in yield prunings should be done in August. In winter pruning, the thickness of the cut branches should not exceed finger thickness. Thicker branches should be made at 15–20 cm lengths in thick branch sections in areas where the disease is very common. As a result, the pruning of cherry trees should be done in winter and July, while in winter prunings yield pruning in thin branches and short cuts should be done in these branches, especially in areas where branch cancer is common, thick branch segments should be left to the end of summer.
Standard tree pruning (mature tree) 40–60 cm
Spur and selfertil cultivars 20–30 cm
Bush tree 5–15 cm
Apical Pruning: Nitrogen uptake stops when branches are cut, carbohydrate is accumulated.
Generally, sweet cherries in Turkey are midseason cherries and grown in June and July. To extend the growing season of cherries and widen the exportation period, cherries were begun to be produced at the subtropical region of Turkey at the Mediterranean coastal line, since the prices at early and late season cherries are very high.
Under subtropical climatic conditions, cherry cultivation experiments started in 1990 with a self-fertile cultivar Stella. The main problem in cherries in this area was not only the insufficient chilling, but also the fertilization problems. The studies began on apple and pear in 1984, and on cherries in 1990 [6]. For this purpose, cherry collection orchards were established in Adana. In the meantime, the chilling requirements of the cultivars and the chilling duration of the area were determined.
Küden et al. [7], determined the performances and the chilling requirements of ‘Stella’, ‘Noir de Guben’, ‘Van’ and ‘Bing’ cherry cultivars and ‘Kütahya’ sour cherry cultivar under subtropical conditions with the classical and chill unit methods. In the study, the chilling requirements were determined as 600–1200 h for ‘Stella’, 700–800 h for ‘Noir de Guben’ and 1000–1200 h for ‘Van’. Considering these results, it was reported that ‘Stella’ and ‘Noir de Guben’ cherry cultivars can be grown under subtropical conditions with some cultural practices. KNO3, thiourea and hydrogen cyanamide (Dormex) were applied to break the dormancy of the buds in cherry cultivars. Among chemical applications, KNO3 + thiourea (2% + 1%) combination gave the best results. The bud broke dormancy 100%, 96%, 92% and 77% respectively on ‘Stella’, ‘Van’, ‘Noir de Guben’ and ‘Bing’.
Küden and Küden [22], stated that ‘Cristobalina’, “Temprano de Sot’, ‘Precoce de Bernard’, ‘Sunburst’, ‘Lapins’, ‘Chelan’ and’ ‘Na-1’were found to be the promising cultivars and adaptable to subtropical climatic conditions.
Imrak et al. [15] studied on ‘Na-1’, ‘Early Van Compact’, ‘Bing Spur’, ‘Lapins’ and ‘Cristobalina’ cherry cultivars under subtropical conditions to prevent or decrease the multiple fruit formation that occurred at the differentiation period of the buds over 30°C. They found the use of green net with a shading feature of 55% used as a cover system to reduce the air temperature values between 1.9°C and 3.1°C and reduced double pistil formation ranging from 60.87% to 27.81% percentages.
Another issue in warm regions is that the cover materials used in cherry orchards are not collected during the winter. In this way, the trees are kept in a cooler environment with the shade effect on sunny days and help to satisfy chilling.
The studies on cherry growing under subtropical conditions continued in three locations began in 2013: 1—Çukurova University, Sarıçam/Adana, 2—Bilici Farm, Ceyhan/Adana, 3—Özler Abdioğlu Farm, Yüreğir, Yakapınar/Adana) with 15 low chilling cherry cultivars planted on 17, 30 and 50 m altitudes, respectively.
Recently, prolonging the cherry season with early and late cherry cultivars extend the cherry exportation season. As a result of the studies carried out at the University of Cukurova, Sweet Heart at high elevations, Royal Lynn® and Royal Tioga® at subtropical climatic conditions were found to be suitable (Figure 6).
The fruit set of new cherry cultivars at low altitudes.
Recently, use of plant growth regulators in cherry cultivation is increasing. Gibberellic acid applications are used in our country to delay ripening period and to increase the fruit size. GA applications on cherry fruits at color changing stage delayed the harvest for 8–10 days. It is better to prune cherry trees together with GA applications to get bigger fruit size as well as delay harvest.
Erger Applications: Manisa Province Sweet Cherry Altitude: 214 m. Cultivar: 0900 Ziraat, Rootstock: Giesela 6.
In this study, chemical applications were found to be effective on breaking dormancy of ‘0900 Ziraat’ sweet cherry cultivar. The chilling duration of the experimental areas were found to be 586 chill units and 1225 h in 2011–2012 winter period while it was 453 chill units and 819 h in 2012–2013 winter period. All treatments were applied (KNO3 8%, Erger 6%), on December 15 (45 days before the end of dormancy duration) using 20 L Knapsack Sprayer. The experimental winter period of 2012–2013 was warmer and had lower chilling accumulation. Therefore, no yield could be obtained from the orchards at 150–200 m height. This study was carried out for 2 years (2011–2013). The capacity of Erger (total nitrogen 15.0%, ureic nitrogen 6.1%, nitric nitrogen 5.8%, ammoniacal 3.1%, water soluble calcium oxide 4.7%), Dormex (hydrogen cyanamide) and potassium nitrate (KNO3) for breaking of dormancy in buds of ‘0900 Ziraat’ sweet cherry cultivar trees were determined (Figure 7).
Comparison of the flowering times of the applications.
Cherry fruits do not continue ripening after harvest. Therefore, the right harvest time should be determined carefully. Generally, the harvest starts after the coloring of the fruits.
Fruit cracking in cherries is an important problem in rainy regions. Also, excessive irrigation of the orchards and prolonged stay in a humid environment increase the rate of fruit cracking. Cracked fruits lost their market value, fungal infections occur in fractured parts. Cracking occurs when water enters into the fruit peel and the fruit swells rapidly. In rainy weather, the fruit volume can increase by 10% as the water enters into the ripen fruit.
There are differences between cultivars in terms of susceptibility to cracking. Bing, Van, Karabodur, Early Burlat are sensitive cherry cultivars to cracking. Generally, cherry cultivars with firm fruit flesh are more susceptible to cracking. It was determined that fruit cracking was decreased with the application of burgundy slurry and copper sulphate on trees before harvest. If 450 g borax/decare was given to the cherry orchards that show boron deficiency, it was found that the cracking rate of cherry cultivars was decreased for about 25–50%. Giberellic acid applications to increase the fruit load and fruit set reduce Ca content of the fruit. The use of plant growth regulators that reduce shoot growth and Giberellin synthesis can increase Ca content of the fruit. Spraying Ca 10 days before the harvest decrease cracking and increase the fruit flesh firmness [23].
Various parameters are used to determine the right harvest time in cherries. Among them, the size, fruit color and amount of Brix value are the most commonly used parameters. Generally, the minimum size for exportable cherry fruit is 26 mm. Cherries are nonclimacteric fruits and they do not ripen after harvest. At the harvest time, cherries should contain at least 14–15% Brix value.
Cherry fruits are very sensitive to mechanical damage and deterioration after harvest. For this purpose, cherries should be precooled quickly after harvest and should be packaged properly by using the correct package products. Continuity of the cold chain is also mandatory during the storage and marketing of packaged products [9, 24].
Cherry (
In 1997, “Turkish National Cherry Working Group” was founded and organized 22 working group meetings until today to solve all the problems of cherries. In these meetings, all the research results were shared and discussed among cherry scientists. These problems were pruning, cultivars, fertilization, rootstocks, irrigation, harvesting, pre-cooling, storage, packing, disease and pest control. Under this working group studies, seminars and conferences were organized at the most important cherry producer regions on training, pruning, rootstocks and growing techniques. With the widespread use of yield pruning in grown cherry trees, fruit yield and quality have increased besides the use of dwarf and semi-dwarf cherry rootstocks.
Some favorite and promising foreign sweet cherry cultivars were introduced in the country alternative to 0900 Ziraat cultivar. Especially with the spread of the late maturing Sweet Heart cultivar the cherry season, which ended at the end of July was extended until mid-August.
Many studies have been carried out on the chilling requirements of sweet cherry cultivars and chilling durations of Çukurova region which has a subtropical climate. As a result of working on low chill cherry cultivars, cherry orchards have started to be established in the subtropical regions.
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Gastropods comprise 80% of the mollusks with approximately 62,000 living species including snails. Over the period of time, snails have evolved into marine, freshwater and terrestrial forms with a transitional shift in their feeding habits. From prehistoric times, mollusks have established an intimate relationship with humans. These animals are used as food, medicine, offering to gods and are also responsible for economic losses in the form of agricultural pests. As most of these animals feed on plant biomass, their guts have evolved to digest such lignocellulosic biomass with extraordinary efficiency. The plant fiber digestion in their guts depends predominantly on the metabolic activities of the gastro‐intestinal microflora. Besides digestive functions, the seasonal dynamic and spatial distribution of bacterial gut community largely influences cold hardiness and many other metabolic properties in snails. Here, we assessed an overview of the various bacterial populations dwelling in digestive tracts of snails. This chapter provides insights into the gut microbiome of various snails that can be exploited for various industrial applications such as biomass degradation, production of biofuel, paper, wine and laundry detergents.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Mudasir A. Dar, Kiran D. Pawar and Radhakrishna S. Pandit",authors:[{id:"201161",title:"Mr.",name:"Mudasir",middleName:null,surname:"Dar",slug:"mudasir-dar",fullName:"Mudasir Dar"},{id:"201162",title:"Prof.",name:"Radhakrishna S",middleName:null,surname:"Pandit",slug:"radhakrishna-s-pandit",fullName:"Radhakrishna S Pandit"},{id:"201163",title:"Dr.",name:"Kiran D",middleName:null,surname:"Pawar",slug:"kiran-d-pawar",fullName:"Kiran D Pawar"}]},{id:"54507",doi:"10.5772/67862",title:"Patellid Limpets: An Overview of the Biology and Conservation of Keystone Species of the Rocky Shores",slug:"patellid-limpets-an-overview-of-the-biology-and-conservation-of-keystone-species-of-the-rocky-shores",totalDownloads:1976,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"This work reviews a broad spectrum of subjects associated to Patellid limpets’ biology such as growth, reproduction, and recruitment, also the consequences of commercial exploitation on the stocks and the effects of marine protected areas (MPAs) in the biology and populational dynamics of these intertidal grazers. Knowledge of limpets’ biological traits plays an important role in providing proper background for their effective management. This chapter focuses on determining the effect of biotic and abiotic factors that influence these biological characteristics and associated geographical patterns. Human exploitation of limpets is one of the main causes of disturbance in the intertidal ecosystem and has occurred since prehistorical times resulting in direct and indirect alterations in the abundance and size structure of the target populations. The implementation of MPAs has been shown to result in greater biomass, abundance, and size of limpets and to counter other negative anthropogenic effects. However, inefficient planning and lack of surveillance hinder the accomplishment of the conservation purpose of MPAs. Inclusive conservation approaches involving all the stakeholders could guarantee future success of conservation strategies and sustainable exploitation. This review also aims to establish how beneficial MPAs are in enhancing recruitment and yield of adjacent exploited populations.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Paulo Henriques, João Delgado and Ricardo Sousa",authors:[{id:"200407",title:"MSc.",name:"Paulo",middleName:null,surname:"Henriques",slug:"paulo-henriques",fullName:"Paulo Henriques"},{id:"200915",title:"MSc.",name:"Ricardo",middleName:null,surname:"Sousa",slug:"ricardo-sousa",fullName:"Ricardo Sousa"},{id:"200916",title:"MSc.",name:"João",middleName:null,surname:"Delgado",slug:"joao-delgado",fullName:"João Delgado"}]},{id:"54666",doi:"10.5772/67995",title:"Mussel as a Tool to Define Continental Watershed Quality",slug:"mussel-as-a-tool-to-define-continental-watershed-quality",totalDownloads:1287,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Bivalves appear as relevant sentinel species in aquatic ecotoxicology and water quality assessment. This is particularly true in marine ecosystems. In fact, several biomonitoring frameworks in the world used mollusks since several decades on the base of contaminant accumulation (Mussel Watch, ROCCH) and/or biological responses called biomarker (OSPAR) measurements. In freshwater systems, zebra and quagga mussels could represent alternative sentinels, which could be seen as the counterparts of mussel marine species. This chapter presents original studies and projects underlying the interest of these freshwater mussels for water quality monitoring based on contaminant accumulation and biomarker development measurements. These sentinel species could be used as a tool for chemical/biological monitoring of biota under the European water framework directive and for the development of effect-based monitoring tools.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Mélissa Palos Ladeiro, Iris Barjhoux, Aurélie Bigot-Clivot, Marc\nBonnard, Elise David, Odile Dedourge-Geffard, Elodie Geba, Emilie\nLance, Maxime Lepretre, Gabrielle Magniez, Damien Rioult,\nDominique Aubert, Isabelle Villena, Gaëlle Daniele, Arnaud\nSalvador, Emmanuelle Vulliet, Jean Armengaud and Alain Geffard",authors:[{id:"14169",title:"Dr.",name:"Aurelie",middleName:null,surname:"Bigot",slug:"aurelie-bigot",fullName:"Aurelie Bigot"},{id:"145053",title:"Dr.",name:"Dominique",middleName:null,surname:"Aubert",slug:"dominique-aubert",fullName:"Dominique Aubert"},{id:"145057",title:"Prof.",name:"Isabelle",middleName:null,surname:"Villena",slug:"isabelle-villena",fullName:"Isabelle Villena"},{id:"199642",title:"Dr.",name:"Melissa",middleName:null,surname:"Palos Ladeiro",slug:"melissa-palos-ladeiro",fullName:"Melissa Palos Ladeiro"},{id:"205006",title:"Dr.",name:"Iris",middleName:null,surname:"Barjhoux",slug:"iris-barjhoux",fullName:"Iris Barjhoux"},{id:"205007",title:"Dr.",name:"Marc",middleName:null,surname:"Bonnard",slug:"marc-bonnard",fullName:"Marc Bonnard"},{id:"205008",title:"Dr.",name:"Elise",middleName:null,surname:"David",slug:"elise-david",fullName:"Elise David"},{id:"205009",title:"Dr.",name:"Odile",middleName:null,surname:"Dedourge Geffard",slug:"odile-dedourge-geffard",fullName:"Odile Dedourge Geffard"},{id:"205010",title:"MSc.",name:"Elodie",middleName:null,surname:"Geba",slug:"elodie-geba",fullName:"Elodie Geba"},{id:"205011",title:"Prof.",name:"Alain",middleName:null,surname:"Geffard",slug:"alain-geffard",fullName:"Alain Geffard"},{id:"205012",title:"Dr.",name:"Emilie",middleName:null,surname:"Lance",slug:"emilie-lance",fullName:"Emilie Lance"},{id:"205013",title:"MSc.",name:"Maxime",middleName:null,surname:"Lepretre",slug:"maxime-lepretre",fullName:"Maxime Lepretre"},{id:"205014",title:"MSc.",name:"Gabrielle",middleName:null,surname:"Magniez",slug:"gabrielle-magniez",fullName:"Gabrielle Magniez"},{id:"205015",title:"Dr.",name:"Gaëlle",middleName:null,surname:"Daniele",slug:"gaelle-daniele",fullName:"Gaëlle Daniele"},{id:"205016",title:"Prof.",name:"Emmanuelle",middleName:null,surname:"Vulliet",slug:"emmanuelle-vulliet",fullName:"Emmanuelle Vulliet"},{id:"205018",title:"Prof.",name:"Arnaud",middleName:null,surname:"Salvador",slug:"arnaud-salvador",fullName:"Arnaud Salvador"},{id:"205019",title:"Prof.",name:"Jean",middleName:null,surname:"Armengaud",slug:"jean-armengaud",fullName:"Jean Armengaud"},{id:"205264",title:"Dr.",name:"Damien",middleName:null,surname:"Rioult",slug:"damien-rioult",fullName:"Damien Rioult"}]},{id:"64501",doi:"10.5772/intechopen.81778",title:"Immune Response of Molluscs",slug:"immune-response-of-molluscs",totalDownloads:1360,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"In common with other invertebrates, molluscs are known to have internal immune response against foreign particles and organisms. The innate immunity of molluscs reflects the inherent non-specific response that provides the first line of defense. Anatomic barriers, phagocytic cells, and physiological components are the main elements of the innate immune response in molluscs. It is composed of both cellular and humoral elements. The cellular components are the circulating hemocytes. Small invaders are eliminated by the phagocytic hemocytes, while large invaders are eliminated by encapsulation. The ingested foreign particles are then hemolyzed by the action of certain toxic enzymes that catalyze oxidative burst reactions capable of killing pathogens and foreign invaders. Humoral components of molluscan immunity involve nitric oxide, lysozyme activity, lectins, and the phenyloxidase system. The current chapter sheds light on the elements of the molluscan innate immune system and presents a case study of the immune response of Lymnaea stagnalis mollusc against Chaetogaster limnaei parasite. The effect of the parasite on some humoral immune response parameters such as nitric oxide, phenol oxidase, and lysozyme production was investigated. In conclusion, the snail Lymnaea stagnalis exerts humoral immune response against Chaetogaster limnaei parasite. However, this response is insufficient to eliminate the parasite.",book:{id:"8289",slug:"molluscs",title:"Molluscs",fullTitle:"Molluscs"},signatures:"Hanan Al-Khalaifah and Afaf Al-Nasser",authors:null},{id:"54501",doi:"10.5772/67811",title:"Lipid Composition Modifications in the Blue Mussels (Mytilus edulis L.) from the White Sea",slug:"lipid-composition-modifications-in-the-blue-mussels-mytilus-edulis-l-from-the-white-sea",totalDownloads:1320,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"Studying biochemical indicators in response to various environmental factors allows revealing the metabolic adaptive strategy of the organism’s tolerance and survival under a variety of environmental impacts. This review analyses both the authors’ own data and the available literature on the problem of biochemical adaptations of the lipid composition in marine bivalves, particularly blue mussels, Mytilus edulis L., to various environmental impacts. Modifications in the composition of lipids and their fatty acids in blue mussels caused by short-term (under laboratory conditions) and chronic (field monitoring) exposure to natural and human factors indicate that homeostasis is maintained in cell membranes and the organism’s energy requirements and facilitate the adaptation and tolerance of the mussels to environmental disturbances. The lipid and fatty acid composition indices in White Sea intertidal mussels which reflect their chronic exposure to a wide variety of environmental factors are discussed and compared to data on changes in the lipid composition of blue mussels exposed to some environmental factors (salinity, anoxia, metals) in aquarium experiments. The lipid profile plays an important role in the adaptation of blue mussels to new conditions in the habitat, and it can be used as a biochemical marker for indicating the organism’s physiological state.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Natalia N. Fokina, Tatiana R. Ruokolainen and Nina N. Nemova",authors:[{id:"199037",title:"Mrs.",name:"Natalia",middleName:null,surname:"Fokina",slug:"natalia-fokina",fullName:"Natalia Fokina"},{id:"199478",title:"Mrs.",name:"Tatiana",middleName:null,surname:"Ruokolainen",slug:"tatiana-ruokolainen",fullName:"Tatiana Ruokolainen"},{id:"199479",title:"Dr.",name:"Nina",middleName:null,surname:"Nemova",slug:"nina-nemova",fullName:"Nina Nemova"}]}],mostDownloadedChaptersLast30Days:[{id:"54507",title:"Patellid Limpets: An Overview of the Biology and Conservation of Keystone Species of the Rocky Shores",slug:"patellid-limpets-an-overview-of-the-biology-and-conservation-of-keystone-species-of-the-rocky-shores",totalDownloads:1976,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"This work reviews a broad spectrum of subjects associated to Patellid limpets’ biology such as growth, reproduction, and recruitment, also the consequences of commercial exploitation on the stocks and the effects of marine protected areas (MPAs) in the biology and populational dynamics of these intertidal grazers. Knowledge of limpets’ biological traits plays an important role in providing proper background for their effective management. This chapter focuses on determining the effect of biotic and abiotic factors that influence these biological characteristics and associated geographical patterns. Human exploitation of limpets is one of the main causes of disturbance in the intertidal ecosystem and has occurred since prehistorical times resulting in direct and indirect alterations in the abundance and size structure of the target populations. The implementation of MPAs has been shown to result in greater biomass, abundance, and size of limpets and to counter other negative anthropogenic effects. However, inefficient planning and lack of surveillance hinder the accomplishment of the conservation purpose of MPAs. Inclusive conservation approaches involving all the stakeholders could guarantee future success of conservation strategies and sustainable exploitation. This review also aims to establish how beneficial MPAs are in enhancing recruitment and yield of adjacent exploited populations.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Paulo Henriques, João Delgado and Ricardo Sousa",authors:[{id:"200407",title:"MSc.",name:"Paulo",middleName:null,surname:"Henriques",slug:"paulo-henriques",fullName:"Paulo Henriques"},{id:"200915",title:"MSc.",name:"Ricardo",middleName:null,surname:"Sousa",slug:"ricardo-sousa",fullName:"Ricardo Sousa"},{id:"200916",title:"MSc.",name:"João",middleName:null,surname:"Delgado",slug:"joao-delgado",fullName:"João Delgado"}]},{id:"54666",title:"Mussel as a Tool to Define Continental Watershed Quality",slug:"mussel-as-a-tool-to-define-continental-watershed-quality",totalDownloads:1287,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Bivalves appear as relevant sentinel species in aquatic ecotoxicology and water quality assessment. This is particularly true in marine ecosystems. In fact, several biomonitoring frameworks in the world used mollusks since several decades on the base of contaminant accumulation (Mussel Watch, ROCCH) and/or biological responses called biomarker (OSPAR) measurements. In freshwater systems, zebra and quagga mussels could represent alternative sentinels, which could be seen as the counterparts of mussel marine species. This chapter presents original studies and projects underlying the interest of these freshwater mussels for water quality monitoring based on contaminant accumulation and biomarker development measurements. These sentinel species could be used as a tool for chemical/biological monitoring of biota under the European water framework directive and for the development of effect-based monitoring tools.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Mélissa Palos Ladeiro, Iris Barjhoux, Aurélie Bigot-Clivot, Marc\nBonnard, Elise David, Odile Dedourge-Geffard, Elodie Geba, Emilie\nLance, Maxime Lepretre, Gabrielle Magniez, Damien Rioult,\nDominique Aubert, Isabelle Villena, Gaëlle Daniele, Arnaud\nSalvador, Emmanuelle Vulliet, Jean Armengaud and Alain Geffard",authors:[{id:"14169",title:"Dr.",name:"Aurelie",middleName:null,surname:"Bigot",slug:"aurelie-bigot",fullName:"Aurelie Bigot"},{id:"145053",title:"Dr.",name:"Dominique",middleName:null,surname:"Aubert",slug:"dominique-aubert",fullName:"Dominique Aubert"},{id:"145057",title:"Prof.",name:"Isabelle",middleName:null,surname:"Villena",slug:"isabelle-villena",fullName:"Isabelle Villena"},{id:"199642",title:"Dr.",name:"Melissa",middleName:null,surname:"Palos Ladeiro",slug:"melissa-palos-ladeiro",fullName:"Melissa Palos Ladeiro"},{id:"205006",title:"Dr.",name:"Iris",middleName:null,surname:"Barjhoux",slug:"iris-barjhoux",fullName:"Iris Barjhoux"},{id:"205007",title:"Dr.",name:"Marc",middleName:null,surname:"Bonnard",slug:"marc-bonnard",fullName:"Marc Bonnard"},{id:"205008",title:"Dr.",name:"Elise",middleName:null,surname:"David",slug:"elise-david",fullName:"Elise David"},{id:"205009",title:"Dr.",name:"Odile",middleName:null,surname:"Dedourge Geffard",slug:"odile-dedourge-geffard",fullName:"Odile Dedourge Geffard"},{id:"205010",title:"MSc.",name:"Elodie",middleName:null,surname:"Geba",slug:"elodie-geba",fullName:"Elodie Geba"},{id:"205011",title:"Prof.",name:"Alain",middleName:null,surname:"Geffard",slug:"alain-geffard",fullName:"Alain Geffard"},{id:"205012",title:"Dr.",name:"Emilie",middleName:null,surname:"Lance",slug:"emilie-lance",fullName:"Emilie Lance"},{id:"205013",title:"MSc.",name:"Maxime",middleName:null,surname:"Lepretre",slug:"maxime-lepretre",fullName:"Maxime Lepretre"},{id:"205014",title:"MSc.",name:"Gabrielle",middleName:null,surname:"Magniez",slug:"gabrielle-magniez",fullName:"Gabrielle Magniez"},{id:"205015",title:"Dr.",name:"Gaëlle",middleName:null,surname:"Daniele",slug:"gaelle-daniele",fullName:"Gaëlle Daniele"},{id:"205016",title:"Prof.",name:"Emmanuelle",middleName:null,surname:"Vulliet",slug:"emmanuelle-vulliet",fullName:"Emmanuelle Vulliet"},{id:"205018",title:"Prof.",name:"Arnaud",middleName:null,surname:"Salvador",slug:"arnaud-salvador",fullName:"Arnaud Salvador"},{id:"205019",title:"Prof.",name:"Jean",middleName:null,surname:"Armengaud",slug:"jean-armengaud",fullName:"Jean Armengaud"},{id:"205264",title:"Dr.",name:"Damien",middleName:null,surname:"Rioult",slug:"damien-rioult",fullName:"Damien Rioult"}]},{id:"55399",title:"Gut Microbiome Analysis of Snails: A Biotechnological Approach",slug:"gut-microbiome-analysis-of-snails-a-biotechnological-approach",totalDownloads:2928,totalCrossrefCites:7,totalDimensionsCites:18,abstract:"Mollusks are a diverse group of animals not only at the species level but also with respect to their habitat and behavior. Gastropods comprise 80% of the mollusks with approximately 62,000 living species including snails. Over the period of time, snails have evolved into marine, freshwater and terrestrial forms with a transitional shift in their feeding habits. From prehistoric times, mollusks have established an intimate relationship with humans. These animals are used as food, medicine, offering to gods and are also responsible for economic losses in the form of agricultural pests. As most of these animals feed on plant biomass, their guts have evolved to digest such lignocellulosic biomass with extraordinary efficiency. The plant fiber digestion in their guts depends predominantly on the metabolic activities of the gastro‐intestinal microflora. Besides digestive functions, the seasonal dynamic and spatial distribution of bacterial gut community largely influences cold hardiness and many other metabolic properties in snails. Here, we assessed an overview of the various bacterial populations dwelling in digestive tracts of snails. This chapter provides insights into the gut microbiome of various snails that can be exploited for various industrial applications such as biomass degradation, production of biofuel, paper, wine and laundry detergents.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Mudasir A. Dar, Kiran D. Pawar and Radhakrishna S. Pandit",authors:[{id:"201161",title:"Mr.",name:"Mudasir",middleName:null,surname:"Dar",slug:"mudasir-dar",fullName:"Mudasir Dar"},{id:"201162",title:"Prof.",name:"Radhakrishna S",middleName:null,surname:"Pandit",slug:"radhakrishna-s-pandit",fullName:"Radhakrishna S Pandit"},{id:"201163",title:"Dr.",name:"Kiran D",middleName:null,surname:"Pawar",slug:"kiran-d-pawar",fullName:"Kiran D Pawar"}]},{id:"78157",title:"Recent Trends in Freshwater Pearl Farming in India",slug:"recent-trends-in-freshwater-pearl-farming-in-india",totalDownloads:221,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Cultured pearls have an important place in international trade. The Vedas, the Bible, and the Koran all mentioned pearls, and they are regarded as one of the highest honours. Pearls are generated in nature when an irritant, such as a sand grain or a parasite, is swept into the pearl molluscs and lodged within it, where it is coated with micro-layers of nacre, a lustrous substance made up of 80–90 per cent aragonite crystals of CaCO3. The ICAR-Central Institute of Freshwater Aquaculture (CIFA), Kausalyaganga, Bhubaneswar, India, has created a base technology for cultivating pearls in freshwater habitats, recognising the scope and value of freshwater pearl production. Indian pond mussel, Lamellidens marginalis is the major species used in freshwater pearl aquaculture. In addition, ICAR-CIFA has pioneered a novel feature of freshwater pearl farming. The Institute has also taken the lead in disseminating freshwater pearl culture technology to the country’s fish farming communities, entrepreneurs, researchers, and students to build a sustainable model for the country’s socio-economic development. In this chapter, we will briefly cover pearls and their types, their historical significance, the spread of pearl mussels of freshwater origin in various countries, pearl biomineralisation, pearl farming techniques, and factors affecting pearl quality, among other things.",book:{id:"10738",slug:"update-on-malacology",title:"Update on Malacology",fullTitle:"Update on Malacology"},signatures:"Shailesh Saurabh, Sweta Pradhan and Sonal Suman",authors:[{id:"415795",title:"Dr.",name:"Shailesh",middleName:null,surname:"Saurabh",slug:"shailesh-saurabh",fullName:"Shailesh Saurabh"},{id:"415797",title:"Mrs.",name:"Sweta",middleName:null,surname:"Pradhan",slug:"sweta-pradhan",fullName:"Sweta Pradhan"},{id:"415799",title:"Ms.",name:"Sonal",middleName:null,surname:"Suman",slug:"sonal-suman",fullName:"Sonal Suman"}]},{id:"55299",title:"An Insightful Model to Study Innate Immunity and Stress Response in Deep‐Sea Vent Animals: Profiling the Mussel Bathymodiolus azoricus",slug:"an-insightful-model-to-study-innate-immunity-and-stress-response-in-deep-sea-vent-animals-profiling-",totalDownloads:1533,totalCrossrefCites:0,totalDimensionsCites:5,abstract:"Deep‐sea environments are, in some cases, largely unexplored ecosystems, where life thrives driven by the geochemical features of each location. Among these environments, chemosynthesis‐based ecosystems, in the Mid Atlantic Ridge, have an exclusive combination of high depth, high sulfur, and high methane concentrations. This is believed to modulate the biological composition of vent communities and influence the overall vent animal transcriptional activity of genes involved in adaptation processes to extreme environments. This opens, thus, the possibility of finding gene expression signatures specific to a given hydrothermal vent field. Regardless of the extreme physicochemical conditions that characterize deep‐sea hydrothermal vents, the animals dwelling around the vent sites exhibit high productivity and thus must cope with toxic nature of vent surrounding, seemingly deleterious to the animals, while developing surprisingly successful strategies to withstand adverse environmental conditions, including environmental microbes and mechanical stress whether ensuing from animal predation or venting activity. The deep‐sea vent mussel Bathymodiolus azoricus has adapted well to deep‐sea extreme environments and represents the dominating faunal community from hydrothermal vent sites in the Mid‐Atlantic Ridge, owing its successful adaptation and high biomasses to specialized exploitation of methane and sulfide sources from venting activity. Its extraordinary capabilities of adapting and thriving in chemosynthesis‐based environments, largely devoid of photosynthetic primary production and characterized by rapid geochemical regime changes are due to symbiotic associations with chemosynthetic bacteria within its large gills. In an attempt to understand physiological reactions in animals normally set to endure extreme deep‐sea environments, our laboratory has undertaken, for the last few years, a series of investigations, aimed at characterizing molecular indicators of adaptation processes of which components of the host defense system has received most attention. This study reviews recent advances on the characterization of molecules and genes participating in immune reactions, using in vivo and ex vivo models, to elucidate cellular and humoral defense mechanisms in vent mussels and the strategies they have adopted to survive under extreme environments.",book:{id:"5899",slug:"organismal-and-molecular-malacology",title:"Organismal and Molecular Malacology",fullTitle:"Organismal and Molecular Malacology"},signatures:"Raul Bettencourt, Inês Barros, Eva Martins, Inês Martins, Teresa\nCerqueira, Ana Colaço, Valentina Costa, Domitília Rosa, Hugo\nFroufe, Conceição Egas, Sergio Stefanni, Paul Dando and Ricardo S.\nSantos",authors:[{id:"201154",title:"Dr.",name:"Raul",middleName:null,surname:"Bettencourt",slug:"raul-bettencourt",fullName:"Raul Bettencourt"},{id:"205564",title:"Dr.",name:"Eva",middleName:null,surname:"Martins",slug:"eva-martins",fullName:"Eva Martins"},{id:"205565",title:"Dr.",name:"Inês",middleName:null,surname:"Martins",slug:"ines-martins",fullName:"Inês Martins"},{id:"205566",title:"Dr.",name:"Inês",middleName:null,surname:"Barros",slug:"ines-barros",fullName:"Inês Barros"},{id:"205567",title:"Ms.",name:"Teresa",middleName:null,surname:"Cerqueira",slug:"teresa-cerqueira",fullName:"Teresa Cerqueira"},{id:"205568",title:"Dr.",name:"Ana",middleName:null,surname:"Colaço",slug:"ana-colaco",fullName:"Ana Colaço"},{id:"205569",title:"Ms.",name:"Valentina",middleName:null,surname:"Costa",slug:"valentina-costa",fullName:"Valentina Costa"},{id:"205570",title:"Ms.",name:"Domitília",middleName:null,surname:"Rosa",slug:"domitilia-rosa",fullName:"Domitília Rosa"},{id:"205571",title:"Dr.",name:"Sergio",middleName:null,surname:"Stefanni",slug:"sergio-stefanni",fullName:"Sergio Stefanni"},{id:"205572",title:"MSc.",name:"Hugo",middleName:null,surname:"Froufe",slug:"hugo-froufe",fullName:"Hugo 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. 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She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. 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Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. 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