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Liam Chen

University of Minnesota United States of America

Liam Chen, MD, Ph.D., is a professor in the Department of Laboratory Medicine and Pathology, at the University of Minnesota Medical School. He holds an adjunct faculty position in the Department of Neurosurgery and the Department of Medical Sciences, at the University of Minnesota. Dr. Chen earned a Ph.D. in Genetics & Developmental Biology at the University of Alberta, Canada. After graduating, he received residence and fellowship training in Anatomic Pathology, Neuropathology, and Molecular Genetic Pathology at Harvard Medical School. Dr. Chenʿ's research is focused on understanding the cellular and molecular biological pathways leading to major neurodegenerative disorders. Meanwhile, he is the Director of the Neuropathology Division at the University of Minnesota Medical Center. Dr Chen has over 100 scholarly works including research articles, reviews, and book chapters. He is a member of numerous editorial boards and grant evaluation/review bodies.

2chapters authored

Chapters authored

CNS High Grade Glioma

By Liam Chen

Since the publication of the 2016 edition of the WHO Classification of CNS Tumors, advances in neuropathology have enhanced our understanding of the molecular underpinnings of CNS tumors, providing new elements to refine their classification and improve pathological diagnosis of these neoplasms. This chapter will review the highlights of the updated recommendations which provide guidance for how even in the absence of histopathological characteristics of the highest malignancy grade, molecular markers can be used to reach a diagnosis of glioblastoma, IDH–wild-type or astrocytoma, IDH-mutant, grade IV. These changes have important implications for the management of patients with CNS tumors in current neuro-oncology practice.

Part of the book: Central Nervous System Tumors

Neuropathology of Huntington’s Disease

By Taylor G. Brown and Liam Chen

Huntington’s disease (HD) is a devastating neurodegenerative disease that results in motor, cognitive, and psychiatric impairments. HD results from an autosomal dominant polyglutamine expansion in the huntingtin (HTT) gene that results in a misfolded and aggregated protein. The disease is uniformly fatal and demonstrates characteristic neuropathological changes. While the striatum is preferentially affected, the cortex and many other brain regions are involved in pathogenesis and show progressive changes throughout the disease.

Part of the book: From Pathophysiology to Treatment of Huntington's Disease

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Motohiro Nonaka

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Christian Rolfo

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