Product slate examples [21].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7818",leadTitle:null,fullTitle:"Social Isolation - An Interdisciplinary View",title:"Social Isolation",subtitle:"An Interdisciplinary View",reviewType:"peer-reviewed",abstract:'This book focuses on an increasingly current phenomenon in various countries around the world. It offers an interdisciplinary point of view with a broad and, at the same time, in-depth vision of the various aspects that can contribute to better understanding social isolation. The authors, who represent different disciplines and belong to different countries of the world, offer high-profile scientific contributions with new perspectives in the field of social security thanks to the originality of their ideas, theories, research, scientific results and suggestions. Understanding all this opens up new horizons towards the new frontiers of knowledge. "I go out. You want to come? The insulation would be too heavy; desperate and crazy on the deserted streets. To demand a destiny."(Sylvia Plath)',isbn:"978-1-78984-759-8",printIsbn:"978-1-78984-758-1",pdfIsbn:"978-1-83880-426-8",doi:"10.5772/intechopen.77635",price:100,priceEur:109,priceUsd:129,slug:"social-isolation-an-interdisciplinary-view",numberOfPages:100,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"db3b513d7d35476f333a0d4a3147935b",bookSignature:"Rosalba Morese, Sara Palermo and Raffaella Fiorella",publishedDate:"April 8th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7818.jpg",numberOfDownloads:4863,numberOfWosCitations:2,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:6,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:11,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 14th 2018",dateEndSecondStepPublish:"February 8th 2019",dateEndThirdStepPublish:"April 9th 2019",dateEndFourthStepPublish:"June 28th 2019",dateEndFifthStepPublish:"August 27th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"214435",title:"Dr.",name:"Rosalba",middleName:null,surname:"Morese",slug:"rosalba-morese",fullName:"Rosalba Morese",profilePictureURL:"https://mts.intechopen.com/storage/users/214435/images/system/214435.jpg",biography:"Rosalba Morese, born in Italy, holds a bachelor\\'s degree in psychology at the University of Parma and a Ph.D. in neuroscience at the University of Turin. She aims to develop new techniques and approaches in cognitive science and social neuroscience. She is an expert in experimental neuroscience, neuroeconomics, psychophysiology, and cognitive and social neuroscience. She performs neuroimaging studies in social contexts in order to investigate neural correlates involved during social interactions, such as, social exclusion, social support, empathy, communicative intention, social decision-making, in-group and out-group settings, etc. She currently works at Università della Svizzera italiana, Lugano, Switzerland.\n\nFor more information: http://usi.to/xuj",institutionString:"Faculty of Biomedical Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Universita della Svizzera Italiana",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo",profilePictureURL:"https://mts.intechopen.com/storage/users/233998/images/system/233998.png",biography:"Sara Palermo has an MSc in clinical psychology and a PhD in experimental neuroscience. She is specialty chief editor of Frontiers in Psychology, Neuropsychology, and scientific director of the Italian National Institute of Philanthropy, Filantropolis. She is a member of the Italian Society of Neuropsychology, the Italian Association of Psychogeriatrics, the Italian Society of Neurology for Dementia, and the Society for Interdisciplinary Placebo Studies. She was a member of the European Innovation Partnership on Active and Healthy Ageing (EIP AHA), for which she was involved in Action Group A3: Action for Prevention of Functional Decline and Frailty. Dr Palermo works as a researcher at the Department of Psychology - University of Turin (Italy) and as Scientific Consultant at the Fondazione IRCCS, Istituto Neurologico Carlo Besta (FINCB), Milan, Italy.",institutionString:"University of Turin, Italy & The Foundation of the Carlo Besta Neurological Institute IRCCS",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"University of Turin",institutionURL:null,country:{name:"Italy"}}},coeditorTwo:{id:"286013",title:"Dr.",name:"Raffaella",middleName:null,surname:"Fiorella",slug:"raffaella-fiorella",fullName:"Raffaella Fiorella",profilePictureURL:"https://mts.intechopen.com/storage/users/286013/images/system/286013.jpeg",biography:"Raffaella Fiorella holds a Master\\'s degree in Medicine and Surgery from the University of Turin. Italy and a Specialization in Child Neuropsychiatry from the Faculty of Medicine and Surgery from the University of Turin, Italy. 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In this chapter, social withdrawal is defined as voluntary isolation prolonged in time that involves the cessation of any form of social relationship and contact with people and the outside. Clinical psychology, psycho-educational interventions, and social neuroscience research \ufefftries to understand what happens when social isolation is experienced. Therefore an interdisciplinary perspective can help to better understand this phenomenon. \ufeffThe deepening of these aspects can help to create new forms of theoretical perspective and of a clinical and psycho-educational intervention to better \ufeffarrange for this new type of maladaptive condition.",signatures:"Rosalba Morese, Sara Palermo, Carlotta Torello and Francesca Sechi",downloadPdfUrl:"/chapter/pdf-download/70694",previewPdfUrl:"/chapter/pdf-preview/70694",authors:[null],corrections:null},{id:"67246",title:"Social Isolation Experienced by Youth in Social Withdrawal: Toward an Interdisciplinary Analysis and Practice",doi:"10.5772/intechopen.86503",slug:"social-isolation-experienced-by-youth-in-social-withdrawal-toward-an-interdisciplinary-analysis-and-",totalDownloads:907,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter offers a critical analysis of social isolation experienced by youth in social withdrawal, who lead a hermetic way of life characterized by self-isolation or seclusion by retreating themselves at home from the rest of the world for a protracted period of time. The alienating experience of social withdrawal is defined with reference to four parameters, namely, time, place, social relations, and social status. By using these parameters, helping professionals can distinguish those who are in the state of social withdrawal at home from those who are not and map out the directions and context that NGOs and helping professionals have to thoroughly address if social isolation is to be overcome and reengagement of secluded youth is to be achieved. By conducting thorough literature review and using relevant empirical data drawn from the first author’s studies and a longitudinal cohort study of secluded youth in Hong Kong, the authors argue that it is important to start where they are and deliver both home-based and community-based interventions so as to give them an enabling environment where they can cultivate a sense of agency and a sense of expectancy for making a breakthrough against social isolation with the support of interdisciplinary research and practice.",signatures:"Victor Wong, John Yuen, Xuebing Su and Jolene Yung",downloadPdfUrl:"/chapter/pdf-download/67246",previewPdfUrl:"/chapter/pdf-preview/67246",authors:[null],corrections:null},{id:"66271",title:"Social Connectedness and Wellbeing of Ageing Populations in Small Islands",doi:"10.5772/intechopen.85358",slug:"social-connectedness-and-wellbeing-of-ageing-populations-in-small-islands",totalDownloads:725,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter presents the findings relating to social connectedness and isolation from a sample survey of the 393 older people aged 65+ years in an island context, the Maldives, where families are often dispersed across many islands due to the nation’s particular geo-spatial features. Maldivian society while traditionally collectivist, is currently showing effects of modern development on its social structures and values. Against this background, the life domain of social connectedness and social isolation is conceptualized. Although operationalized to include the community, the findings stress the importance of family and friends, rather than the community, in providing social connectedness. There is an indication that family and friends provide experiences that differ emotionally and that varied composition of social networks provide different experiences for social connectedness. Factors within this life domain demonstrate specific aspects of social connectedness in the small island context in contrast to industrialized country contexts.",signatures:"Sheena Moosa",downloadPdfUrl:"/chapter/pdf-download/66271",previewPdfUrl:"/chapter/pdf-preview/66271",authors:[null],corrections:null},{id:"64853",title:"Engaging College Men in Conversations and Activities Related to Dating and Domestic Violence",doi:"10.5772/intechopen.81514",slug:"engaging-college-men-in-conversations-and-activities-related-to-dating-and-domestic-violence",totalDownloads:859,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter describes a unique effort to engage college men in discussion and activism about dating and domestic violence. Given that dating violence is one of the most frequently occurring forms of violence on college campuses, it is imperative that campuses provide education and programming about its scope, extent, and characteristics, as well as inform students how they can receive help. Even more, campuses have a responsibility to encourage students to take action to remedy social problems like dating violence. Yet engaging men in such efforts can be challenging, given that many still see dating and domestic violence as “women’s issues” or do not feel welcome in such movements. The chapter describes an initiative called the College Brides Walk, which integrates experiential learning as a tactic for engaging men. It concludes with lessons learned and recommendations.",signatures:"Laura Finley",downloadPdfUrl:"/chapter/pdf-download/64853",previewPdfUrl:"/chapter/pdf-preview/64853",authors:[null],corrections:null},{id:"68074",title:"The Clash of Cultures: Digerati and Devolution in the Twenty-First Century",doi:"10.5772/intechopen.85844",slug:"the-clash-of-cultures-digerati-and-devolution-in-the-twenty-first-century",totalDownloads:690,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"For over two decades, evolving digital platforms have connected human societies and nations enabling the rapid diffusion of information in patterns mimicking starling murmuration. Despite technological prowess, the digerati of the twenty-first century (Gens X, Y, Z), can be both informed and fooled by well-placed memes. Take a lesson from scientists Henri Milne-Edwards and Emile Durkheim in the 1800s. Their world of connection was nascent. Yet, they grappled with similar issues regarding the intended and unintended consequences of the interrelationship between the size and complexity of connection. For Milne-Edwards, he focused on the size and complexity of organisms later influencing Darwin and Durkheim. As for Durkheim, he examined society and its divisions of labor and the unintended consequence of social isolation and suicide. The malady of the infinite, as Durkheim labeled the socially disengaged, dealt with societal segmentation and isolation of individuals. This commentary addresses the elementary network structures of societal segmentation. Today’s digital society is wildly connected as never before, and yet, the social ills of isolationism linger. Regardless of the ubiquitous connection, individuals are wantonly socially isolated. It is further suggested here that passively monitoring digitized data, such as that being explored and tested in China, may provide a viable, implementable and corrective course for isolationism.",signatures:"Karen Stephenson",downloadPdfUrl:"/chapter/pdf-download/68074",previewPdfUrl:"/chapter/pdf-preview/68074",authors:[null],corrections:null},{id:"68487",title:"Deprivation of Social Play: Implications for the Mechanisms of Autism Spectrum Disorders",doi:"10.5772/intechopen.88311",slug:"deprivation-of-social-play-implications-for-the-mechanisms-of-autism-spectrum-disorders",totalDownloads:785,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Social play emerges in early adolescence and is one of the primary types of social interaction seen early in life in mammals. The experience of social play is essential for the normal trajectory of social and cognitive development. Adolescent mammals deprived opportunities for social interaction at this age display neurodevelopmental abnormalities. Social deprivation alters adult behavioral patterns, neuroanatomy, and neurochemistry in ways that resemble autism spectrum disorder (ASD). These deficits include impairments in communication, social perception, and social behavior. However, the symptom most characteristic of the earliest stage of ASD is decreased interest in social objects. Understanding the role of early social experience, especially play, in the development of social, cognitive, and emotional functioning will provide insight into the development of ASD. In order to understand how social deprivation can affect behavior, researchers isolate animals during early adolescence. Most studies have looked at rodents since it appears that isolation-rearing of rodents has detrimental effects on social development, making it a valid model of ASD. 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Shahjahan Kabir",slug:"m.-shahjahan-kabir",email:"kabir.stat@gmail.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}}]}},chapter:{id:"76501",slug:"enhancing-abiotic-stress-tolerance-to-develop-climate-smart-rice-using-holistic-breeding-approach",signatures:"M. Akhlasur Rahman, Hasina Khatun, M. Ruhul Amin Sarker, Hosneara Hossain, M. Ruhul Quddus, Khandakar M. Iftekharuddaula and M. Shahjahan Kabir",dateSubmitted:"March 6th 2021",dateReviewed:"March 17th 2021",datePrePublished:"June 10th 2021",datePublished:"December 22nd 2021",book:{id:"11571",title:"Cereal Grains",subtitle:"Volume 2",fullTitle:"Cereal Grains - Volume 2",slug:"cereal-grains-volume-2",publishedDate:"December 22nd 2021",bookSignature:"Aakash Kumar Goyal",coverURL:"https://cdn.intechopen.com/books/images_new/11571.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"97604",title:"Dr.",name:"Aakash K.",middleName:null,surname:"Goyal",slug:"aakash-k.-goyal",fullName:"Aakash K. Goyal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"338812",title:"Dr.",name:"M. Akhlasur",middleName:null,surname:"Rahman",fullName:"M. Akhlasur Rahman",slug:"m.-akhlasur-rahman",email:"akhlas08@gmail.com",position:null,institution:null},{id:"340364",title:"Dr.",name:"Hasina",middleName:null,surname:"Khatun",fullName:"Hasina Khatun",slug:"hasina-khatun",email:"hasinabrri09@gmail.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}},{id:"340367",title:"Dr.",name:"Hosneara",middleName:null,surname:"Hossain",fullName:"Hosneara Hossain",slug:"hosneara-hossain",email:"shimulbrri@gmail.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}},{id:"340368",title:"Dr.",name:"M. Ruhul Amin",middleName:null,surname:"Sarker",fullName:"M. Ruhul Amin Sarker",slug:"m.-ruhul-amin-sarker",email:"mrasbrri@yahoo.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}},{id:"340369",title:"Dr.",name:"Khandakar M.",middleName:null,surname:"Iftekharuddaula",fullName:"Khandakar M. Iftekharuddaula",slug:"khandakar-m.-iftekharuddaula",email:"kiftekhar03@yahoo.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}},{id:"352116",title:"Mr.",name:"M. Ruhul",middleName:null,surname:"Quddus",fullName:"M. Ruhul Quddus",slug:"m.-ruhul-quddus",email:"rquddus265@gmail.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}},{id:"352118",title:"Dr.",name:"M. Shahjahan",middleName:null,surname:"Kabir",fullName:"M. Shahjahan Kabir",slug:"m.-shahjahan-kabir",email:"kabir.stat@gmail.com",position:null,institution:{name:"Bangladesh Rice Research Institute",institutionURL:null,country:{name:"Bangladesh"}}}]},book:{id:"11571",title:"Cereal Grains",subtitle:"Volume 2",fullTitle:"Cereal Grains - Volume 2",slug:"cereal-grains-volume-2",publishedDate:"December 22nd 2021",bookSignature:"Aakash Kumar Goyal",coverURL:"https://cdn.intechopen.com/books/images_new/11571.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"97604",title:"Dr.",name:"Aakash K.",middleName:null,surname:"Goyal",slug:"aakash-k.-goyal",fullName:"Aakash K. Goyal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"6852",leadTitle:null,title:"Nanofibers - from Preparation to Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tIn recent years the synthesis of polymers with controlled morphology is one of the big deals in the polymer science and technology. With the emergence of nanotechnology, researchers become more interested in studying the unique properties of nanoscale materials. There are different ways to produce polymeric nanofibers, as example the polymerization of aromatic monomers into media having large organic acids. Uniform nanofibers (from 30 to 200 nm) can also be obtained when the polymerization is done at an aqueous-organic interface. Thus, the template-free methods, such as interfacial, seeding and micellar can be employed as different “bottom-up” approaches to obtain pure polymeric nanofibers. The possibility to prepare nanostructured polymers by self-assembly with reduced post-synthesis processing warrants further study and application of these materials, especially in the field of nanomaterials. The notable applications include in tissue engineering, biosensors, filtration, wound dressings, drug delivery, and enzyme immobilization. In this book, this amazing new area of polymeric nanofibers will be reviewed concerning the state-or-art results of synthesis, spectroscopic characterization and applications. The main goal of this book is to contribute in the rationalization of some important results obtained in this open area of polymeric nanofibers.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"a0e27f82282826770dcb5d3dde15d1b5",bookSignature:"Prof. Gustavo Morari Do Nascimento",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/6852.jpg",keywords:"Nanofibers, Polymers, Composites, Spectroscopy, Characterization, Functionalization, Synthesis, Fire-Retardant, Modified Electrodes, FTIR, Raman, Synchrotron Techniques",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 11th 2018",dateEndSecondStepPublish:"July 2nd 2018",dateEndThirdStepPublish:"August 31st 2018",dateEndFourthStepPublish:"November 19th 2018",dateEndFifthStepPublish:"January 18th 2019",remainingDaysToSecondStep:"4 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento",profilePictureURL:"https://mts.intechopen.com/storage/users/7153/images/system/7153.jpg",biography:"Dr. Gustavo Morari do Nascimento is a professor at the Federal University of ABC, Brazil. He obtained a Ph.D. from the University of São Paulo (USP), Brazil, in 2004. Since completing a postdoctorate at Massachusetts Institute of Technology (MIT), USA, in 2008, Dr. Morari do Nascimento has been working with carbon allotropes, conducting polymers, and conducting polymer-clay nanocomposites. His current research focuses on molecular characterization of chemically modified carbon nanostructured materials with molecular magnets and organic chalcogenide compounds by using FT-Raman spectroscopy, resonance Raman, surface-enhanced Raman spectroscopy (SERS), resonance Raman imaging, and X-ray absorption techniques at the Brazilian Synchrotron Light Laboratory.",institutionString:"Federal University of ABC",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"208",title:"Material Science",slug:"nanotechnology-and-nanomaterials-material-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"205697",firstName:"Kristina",lastName:"Kardum Cvitan",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/205697/images/5186_n.jpg",email:"kristina.k@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6257",title:"Raman Spectroscopy",subtitle:null,isOpenForSubmission:!1,hash:"197e92d225b1d9aae4fe4bd106897d94",slug:"raman-spectroscopy",bookSignature:"Gustavo Morari do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/6257.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5073",title:"Clays, Clay Minerals and Ceramic Materials Based on Clay Minerals",subtitle:null,isOpenForSubmission:!1,hash:"5fabe9873702a3823c66170984aa141e",slug:"clays-clay-minerals-and-ceramic-materials-based-on-clay-minerals",bookSignature:"Gustavo Morari do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/5073.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9313",title:"Clay Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6fa7e70396ff10620e032bb6cfa6fb72",slug:"clay-science-and-technology",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/9313.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10949",title:"Clay and Clay Minerals",subtitle:null,isOpenForSubmission:!1,hash:"44d08b9e490617fcbf7786c381c85fbc",slug:"clay-and-clay-minerals",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/10949.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7640",title:"Perspective of Carbon Nanotubes",subtitle:null,isOpenForSubmission:!1,hash:"8b85a9957fad5206369eadf0c1ffa27d",slug:"perspective-of-carbon-nanotubes",bookSignature:"Hosam El-Din Saleh and Said Moawad Mohamed El-Sheikh",coverURL:"https://cdn.intechopen.com/books/images_new/7640.jpg",editedByType:"Edited by",editors:[{id:"144691",title:"Prof.",name:"Hosam",surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6408",title:"Novel Nanomaterials",subtitle:"Synthesis and Applications",isOpenForSubmission:!1,hash:"f3585d338d78e4d31c200d9991b03692",slug:"novel-nanomaterials-synthesis-and-applications",bookSignature:"George Z. 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Mitropoulos",coverURL:"https://cdn.intechopen.com/books/images_new/6408.jpg",editedByType:"Edited by",editors:[{id:"152296",title:"Prof.",name:"George",surname:"Kyzas",slug:"george-kyzas",fullName:"George Kyzas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6833",title:"Chemical Vapor Deposition for Nanotechnology",subtitle:null,isOpenForSubmission:!1,hash:"31d2b0b2a437691b6a657030687b0096",slug:"chemical-vapor-deposition-for-nanotechnology",bookSignature:"Pietro Mandracci",coverURL:"https://cdn.intechopen.com/books/images_new/6833.jpg",editedByType:"Edited by",editors:[{id:"80989",title:"Prof.",name:"Pietro",surname:"Mandracci",slug:"pietro-mandracci",fullName:"Pietro Mandracci"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6326",title:"Novel Aspects of Nanofibers",subtitle:null,isOpenForSubmission:!1,hash:"6585d128fb06c600192cc380a8eec4cb",slug:"novel-aspects-of-nanofibers",bookSignature:"Tong Lin",coverURL:"https://cdn.intechopen.com/books/images_new/6326.jpg",editedByType:"Edited by",editors:[{id:"49937",title:"Dr.",name:"Tong",surname:"Lin",slug:"tong-lin",fullName:"Tong Lin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6501",title:"Electrospinning Method Used to Create Functional Nanocomposites Films",subtitle:null,isOpenForSubmission:!1,hash:"c28620c5ccc64e4b32eb9758302a1679",slug:"electrospinning-method-used-to-create-functional-nanocomposites-films",bookSignature:"Tomasz Tański, Pawel Jarka and Wiktor Matysiak",coverURL:"https://cdn.intechopen.com/books/images_new/6501.jpg",editedByType:"Edited by",editors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7554",title:"Functional Materials",subtitle:null,isOpenForSubmission:!1,hash:"5519dce9bc7d81f85ac967824eb508b8",slug:"functional-materials",bookSignature:"Dipti Sahu",coverURL:"https://cdn.intechopen.com/books/images_new/7554.jpg",editedByType:"Edited by",editors:[{id:"251855",title:"Prof.",name:"Dipti Ranjan",surname:"Sahu",slug:"dipti-ranjan-sahu",fullName:"Dipti Ranjan Sahu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"53413",title:"The Memory Activation of NK Cells: New Methods in Cancer Immunotherapy",doi:"10.5772/66555",slug:"the-memory-activation-of-nk-cells-new-methods-in-cancer-immunotherapy",body:'\nCancer represents one of the major causes of mortality, despite huge research efforts for deciphering the molecular mechanisms of disease and for developing new targeted and personalized therapeutic approaches with acceptable side effects. There are still problems to overcome, which are linked to the following: (a) heterogeneity of cancer cells within tumors, which is mirrored in their response to a specific therapy; for example, cancer stem cells possess inherent mechanisms for self‐repair and renewal and are therefore often responsible of tumor recurrence and metastasis; (b) complex mechanisms by which tumor cells avoid the innate and adaptive immune responses (adaptability, versatility, mimicry), including by immune suppression induction [1].
\nIn addition to conventional therapeutic approaches (chemo‐ and radiotherapy), we face the shifting of the attention to the immune antitumor defense mechanisms which might offer a steady improvement to conventional therapies for tumor cells eradication. Cancer defiantly induces immune suppression and this is further deepened by anticancer therapies, which weaken the immune response, apart from killing tumor cells [2, 3].
\nIn the last decade, immunotherapy gained a leading position in cancer research and management, due to promising results recently reported in clinical studies for (a) vaccines (sipuleucel‐T) and monoclonal antibodies (ipilimumab), (b) recombinant cytokines and hematopoietic growth factors, and (c) cellular and gene therapies.
\nThe adoptive transfer of lymphocytes with high antitumor reactivity can trigger tumor regression in metastatic melanoma [4–6]. Nowadays, autologous T lymphocytes are clinically used.
Natural killer cells are a component of the innate immune response against viruses and malignant cells. Individuals having low NK cells activity are at risk to develop cancer [7]. The presence of high NK cells number within the tumor confers a good prognostic for cancer patients [8]. NK cells represent a relatively poor population, about 1–32% from the peripheral lymphocytes in healthy individuals [9]. As opposed to T cells, which hold MHC‐restricted antigen specificity, NK cells are able to directly and quickly lyse target cells without the need of an initial sensitization. It was proven that many types of tumor cells express high levels of ligands for NK cells receptors [10], which leads to their recognition and killing by NK cells [11]. The role of NK cells is regulated by (a) cytokines and chemokines which interact with inhibiting or activating receptors on NK cells [12, 13]; (b) communication with other immune cells, such as dendritic cells [14], effector TCD4+ lymphocytes [15] and regulatory T lymphocytes [16].
\nUntil now, therapies with NK cells have been successful mainly for patients with leukemia [17–22], but adoptive transfer of interleukin (IL)‐2‐activated NK cells in patients with solid tumors (melanoma or renal carcinoma) did not show clear clinical benefits [23]. Based on the fact that NK cells possess the memory of being previously activated [23–29], new strategies can be developed for enhancing
It was shown that the multiplication of NK cells can be achieved by modulation with cytokines [30–38]. The development of the methods for growing human NK cells in vitro has incited a special interest for immunotherapy [32, 36, 39–41]. With the development of methods for multiplication of human NK cells in vitro, these cells have incited a special interest for immunotherapy.
NK cells are large granular cells that play a major role in the innate immune response against viruses, bacteria, as well as malignant cells [12, 24, 42]. They were first identified in 1975 by their ability to kill tumor cells without MHC restriction or prior sensitization to tumor antigens [43–45]. The name “natural killer” refers to their natural occurrence and spontaneous ability to kill malignant cells in non‐immunized animals. NK cells are found in a variety of lymphoid and nonlymphoid tissues, including bone marrow, lymph nodes, spleen, peripheral blood, liver and lung. NK cells develop in the bone marrow from a common lymphoid progenitor cells.
\nNK cells are characterized by the expression of CD16 and CD56 surface antigens and the lack of CD3/T‐cell receptor molecules. In humans, there are two subsets of NK cells based on CD56 expression levels: CD56dim and CD56bright. Morphologically, the CD56dim NK cells are large granular lymphocytes, while CD56bright NK cells are small lymphocytes. The CD56dim subset represents the majority of NK cell population in the peripheral blood and spleen (90–95%), exhibit a high cytotoxic potential after interaction with target cells [46, 47]. They produce negligible amounts of cytokines and bear the Fc receptors (CD16) to mediate antibody‐dependent cell‐mediated cytotoxicity (ADCC). In contrast, the CD56bright subset predominates (approximately 90%) in lymph nodes and tonsils, have poor cytotoxic activity and produce very significant amounts of cytokines and chemokines [48]. The CD56bright NK cells produce chemokines and cytokines in response to cytokine stimulation, while the CD56dim population chemokines and cytokines production is stimulated by target cell recognition.
\nThese subsets also differ in the expression of interleukin (IL)‐2 receptor α chain (IL‐2Rα/CD25). CD56bright subset exclusively expresses CD25, while the CD56dim subset lacks CD25 expression. There are differences in receptor expression between the two subsets of NK cells. As opposed to the CD56bright NK cells, CD56dim NK cells express high levels of killer‐cell immunoglobulin‐like receptors (KIRs) and low levels of CD94/natural killer group 2 (NKG2) receptors. These differences have been correlated with the specific alloreactive properties of CD56dim NK cells due to their high KIR levels and their ability to kill various tumor cells [49].
\nThe murine NK cells do not express CD56 marker, but they can be divided in four subsets according to the expression of CD11b and CD27 markers: CD11blowCD27low, CD11blowCD27high, CD11bhighCD27high, CD11bhighCD27low [50]. Mouse CD27high NK cells predominate in lymph nodes and produce large amounts of cytokines, but in contrast with CD56bright NK cells, they have cytotoxic potential. In humans, expression of CD11b and CD27 markers have also revealed four subsets of NK cells with distinct maturation stages, tissue distribution patterns and functional properties [51, 52].
\nThe NK cell activating receptor NKp46 (Ncr1), in contrast to other human NK cell markers (CD56, CD16) or murine NK cell markers (NK1.1, DX5), is almost exclusively expressed by NK cells, and it can be used as an additional marker for identify NK cells [53, 54].
NK cells do not express rearranged, antigen‐specific receptors, but they express a variety of germ‐line encoded receptors that can recognize ligands on their cellular targets.
\nNK cell function, including proliferation, production of cytokines and chemokines, natural killing, lymphokine‐activated killing and ADCC, depends on an intricate balance between signals from inhibitory and activating receptors. The activating receptors interact with ligands expressed on stressed, infected, or transformed cells, or antibody‐opsonized targets (CD16/FcγRIIIa), while inhibitory receptors recognize MHC class I or class I‐like molecules [11].
\nInhibitory receptors include killer immunoglobulin‐like receptors (KIRs), the c‐type lectin, NKG2A/CD94 and leukocyte immunoglobulin‐like receptors (LILRs) [55]. The ligands for these inhibitory receptors are mostly the major histocompatibility complex class‐I (MHC‐I) molecules. Inhibitory signals prevent NK cells from becoming activated, blocking degranulation and cytokine production. Ligation of MHC‐I molecules to the inhibitory receptors acts as a form a NK cell tolerance. By this mechanism, NK cells save healthy cells from killing as long as they express normal levels of MHC class I molecules and low amounts of stress‐induced self‐molecules. During the NK cell development, signals coming from inhibitory receptors help NK cells to be “educated” to respond to MHC‐I deficient cells [56].
\nActivating receptors include the natural cytotoxicity receptors or NCRs, the c‐type lectins, NKG2D and NKG2C/CD94, the SLAM family receptors and others. NK cells express the low‐affinity Fc receptor or CD16 and the death ligands FasL and tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) that after interaction with death receptors induce apoptosis of the target cell. Although some of the ligands to activation receptors are already present on healthy cells, the expressions of many of them are induced upon cell stress [57].
\nIn case of cellular transformation or viral infection, surface MHC class I expression on the cell surface is downregulated or lost to escape from recognition by T cells. When mature NK cells encounter that cell, their inhibitory receptors are not engaged, and the unsuppressed activating signals can trigger cytokine secretion and attack of the targeted cell. In parallel, cellular stress and DNA damage upregulate “stress ligands” that can be recognized by activating NK receptors.
\nNK cells kill tumor targets through a variety of mechanisms, including release of cytoplasmic granules containing perforin and granzyme, expression of tumor necrosis factor (TNF) family members FasL or TNF‐related apoptosis‐inducing ligand (TRAIL), that induce tumor cell apoptosis by interacting with their respective receptors Fas and TRAIL receptor (TRAILR) as well as ADCC [58].
\nDuring tumor progression, tumor cells develop the ability through which they escape from NK cell response. These mechanisms include downregulation of adhesion molecules, costimulatory ligands or ligands for activating receptors, upregulation of MHC‐I molecules, soluble MIC, FasL or NO expression [59, 60], secretion of immunosuppressive factors such as IL‐10, transforming growth factor (TGF)‐β or indoleamine 2,3‐dioxygenase (IDO) and resisting Fas‐ or perforin‐mediated apoptosis [61]. In cancer patients, there are observed some NK cell defects, including decreased numbers in peripheral blood and in tumor infiltrate, reduced expression of activation receptor or intracellular signaling molecules and overexpression of inhibitory receptors, decreased cytotoxicity, defective proliferation and cytokine production.
Cytokines are the main regulators of growth, proliferation, survival and differentiation for various cell types involved in the innate and adaptive immunity. The exhibition of NK cells to cytokines induces enhanced proliferation, augmented cytokine production, higher cytotoxicity against target cells and upregulation of cytotoxic and adhesion molecules. The common γ‐chain interleukins (ILs) such as IL‐2, IL‐15, IL‐21 can activate NK cells, and the combination of IL‐12 and IL‐18 is especially potent to trigger interferon (IFN)‐γ.
\nIL‐2 and IL‐15 are the best studied cytokine activators of NK cells; they have central role for NK cell development and homeostasis, induce proliferation, costimulate cytokine production and enhance cytotoxic effector mechanisms. The both cytokine share the IL‐2/15R
IL‐21 is a cytokine structurally‐related to IL‐2, IL‐4, IL‐15. IL‐21Rα is expressed by lymphoid tissues, shows similarities with IL‐2/IL‐15R β chain and forms a complex with the common γ chain [73]. IL‐21 exerts antitumor effects through its ability to induce activation and proliferation of cytotoxic cells (T CD8+ cytotoxic lymphocytes, NK cells, NKT cells). Meanwhile, IL‐21 suppresses Foxp3 expression and the expansion of immunosuppressive Treg lymphocytes. Accordingly, IL‐21 was associated with antitumor activity in clinical practice [74]. The discovery of IL‐21 was linked to its role in NK cells proliferation and maturation. Further studies have provided however contradictory data, highlighting both the activator and the suppressor role of IL‐21. Soluble IL‐21 alone does not induce significant proliferation in mature mouse NK cells, and IL‐21R knockout mice possess normal NK cells number. Meanwhile, IL‐21 synergizes with IL‐2, IL‐15 and Flt‐3L for NK cells generation in the bone marrow and in umbilical cord blood. IL‐21 can activate the cytotoxic activity of NK cells through over expression of costimulating receptors and cytolytic molecules (perforin, granzymes). IL‐21 enhances multipotent progenitor maturation from bone marrow and activates peripheral NK cells in the absence of other stimuli.
\nIL‐12, originally identified as “NK cell stimulatory factor (NKSF)” based on its ability to enhance NK cell cytotoxicity. The primary effects of IL‐12 on NK cells are IFN‐γ and TNF‐α production. In vitro and in vivo studies have shown that IL‐12 acts on NK cells in concert with other activating cytokines, such as IL‐2 and IL‐18, or with receptor‐based interactions from pathogenic cells.
\nAlthough the IL‐18Rα is constitutively expressed on unstimulated NK cells and can induce NK cell proliferation alone, IL‐18 has been described as a costimulatory cytokine that functions synergistically with IL‐12 and IL‐15. NK cells from IL‐18 deficient mice have impaired cytotoxicity and IFN‐γ production. These findings indicate the importance of IL‐18 to NK‐mediated host defense.
\nSuccessful adoptive cell transfer (ACT) and
Based on results from experimental animal models, adoptive transfer of autologous NK cells seems to be safe and promising for cancer therapy. Initial trials of adoptive NK cells involved infusion of CD56 bead‐selected autologous NK cells from a leukapheresis product followed by administration of systemic cytokines [75]. Upon cytokine stimulation, NK cells become lymphokine‐activated killer (LAK) cells and exhibit greater cytotoxicity against tumor cells. Although administration of cytokines improve the antitumor activity of NK cells in vitro, only limited antitumor activity of LAK cells was observed in cancer patients [23]. Similar results were also obtained when autologous NK cells and systemic IL‐2 were administrated to patients with lymphoma. Partially effective clinical outcomes were observed in metastatic renal cell carcinoma (RCC) patients that received a combination of high‐dose IL‐2 and LAK cell infusions, while treatment of non‐Hodgkin\'s lymphoma and RCC patients with
As was shown, adoptively transferring autologous NK cells was found to greatly improve clinical responses without any obvious adverse side effects in some cancers. However, these NK cells could not yet exhibit their full cytotoxic capacity in vivo, this may be due to many tumors expressing high levels of human leukocyte antigen (HLA) class I receptor and/or low levels of ligands for activating receptors that suppress autologous NK cells in vivo. For these reasons, they are focused on therapies using allogenic NK cells from related donors or other strategies to prevent such NK cell resistance.
Using the allogeneic NK cells has the advantage of the inherent alloreactivity afforded by the “missing self” concept. When donor NK cells encounter an altered MHC environment, the NK cells can be “re‐educated” by host HLA and can acquire cytotoxicity against host tumor cells without causing graft versus host disease (GVHD). Allogenic NK cells with KIR mismatch have greater tumor‐killing activity and the ability to control acute myeloid leukemia (AML) relapse [77, 78]. Adoptively transferred human‐mismatched (haploidentical) allogeneic NK cells have been shown to be a safe therapy with minimal toxicity and have been more successful for cancer immunotherapy, including against leukemia and solid cancers. In some clinical trials using adoptively transferred haploidentical allogeneic NK cells to treat AML patients, including pediatric AML patients and older AML patients no graft‐versus‐host disease (GvHD) response was observed and NK cell therapy was well tolerated. Besides hematopoietic‐derived tumors, strategies using adoptively transferred haploidentical allogeneic NK cells can also expand in patients with various malignancies, including metastatic melanoma, renal cell carcinoma, Hodgkin\'s disease and poor‐prognosis AML
NK cells are traditionally considered members or the innate branch of the immune system that responds rapidly but lack immunologic specificity in the form of a clonal antigen receptor and memory of prior activation. Recently several groups have challenged this paradigm of NK cells as pure innate lymphocytes and demonstrated memory‐like functions in NK cells.
\nThe immune system capacity to learn from previous encounters with pathogens, and respond more rapidly and effectively upon secondary infection has been termed adaptive immunity or immunological memory. After primary encounter with antigen, naïve antigen‐specific T or B cells proliferate vigorously and some of them differentiate into memory cells [79]. This stage represents the expansion phase, when the naïve cells clonally expand. Following the primary response, in the contraction phase, the majority of effector cells die and surviving cells enter the memory phase. Upon reencounter with their cognate antigen, memory cells exert their functional responses more rapidly than do naïve cells. This response to a second antigen exposure called the “recall response.”
\nAntigen‐specific responses and memory responses, both are hallmarks of adaptive immunity. Innate responses do not require pre‐sensitization and rely on germline encoded receptors and do not require clonal expansion. NK cells have long been categorized as a component of innate immunity. Although NK cells lack the ability to undergo somatic rearrangements of their receptors, these cells are developmentally and functionally more related to adaptive immune lymphocytes than innate immune cells.
\nInitially it was believed that NK cells act in the first days of infection, but now we know that NK cells function in parallel and complementary to the adaptive immune response over extended periods of time. Moreover, there are many evidences for adoptive‐like features of NK cells. Evidence for adoptive‐like features of NK cells has come from a variety of studies, and NK cell‐mediated memory can be generated in response to haptens, viruses and following combined cytokine activation.
\nNK cell memory was first described in a mouse model of hapten‐induced contact hypersensitivity (CHS), induced by chemical haptens such as 2,4‐dinitro‐1‐fluorobenzene (DNFB) and 4‐ethoxymethylene‐2‐phenyloxazol‐5‐one (oxazolone) and picryl chloride [25]. T‐ and B‐deficient mice developed vigorous specific contact hypersensitivity responses to haptens and response persisted for at least four weeks. The mice exhibited enhanced recall responses to the same chemical, but not to a different one, demonstrating antigen specificity. Furthermore, contact hypersensitivity responses could be conferred to naive mice by adoptive transfer of natural killer cells from sensitized mice.
\nThese responses possessed the hallmarks of adaptive immunity: they were sensitization dependent, persisted for at least four weeks and were only elicited by haptens to which mice had previously been sensitized. These observations indicate that natural killer cells can mediate long‐lived, antigen‐specific adaptive recall responses independent of B cells and T cells. It was shown that transfer of a subset of liver‐derived NK cells, not splenic or naïve NK cells, could confer the recall response. NK cell memory to haptens depended on expression of CXCR6, a chemokine receptor on hepatic NK cells critical for intrahepatic survival and homeostasis [80]. CXCR6 is a chemo‐attractant receptor which is expressed on roughly 50% of liver NK cells. The molecular mechanism leading to the generation of antigen‐specific memory NK cells remained elusive
Also, NK cells could mount recall responses to diverse viral antigens such as vesicular stomatitis virus (VSV), virus‐like particles (VLP) containing influenza A‐derived hemaglutinin and/or matrix protein 1, or VLP containing the HIV‐1‐derived Gag protein and/or Env protein [80]. In order to confer the recall response, liver NK cells had to express the CXCR6. Blocking CXCR6 with antibodies can impair the recall response. NK cells can respond more vigorously upon secondary stimulation against challenges with additional irritants (such as fluorescein isothiocyanate [FITC]), as well as the viruses vaccinia, and herpes simplex virus (HSV)‐2 [81–83].
\nA central issue that remains unresolved is how NK cells can recognize and differentiate between all these different antigens, since there are no known VSV, vaccinia, HSV‐2, or HIV‐specific NK receptors. The ability of NK cells to respond to such a wide diversity of distinct antigens, including pathogens that are not endemic to mice, such as HIV1, is puzzling and suggests that a hitherto unknown recombination-activating genes (RAG)-independent receptor diversification mechanism may exist in NK cells [84].
\nMost of the evidence that NK cells exhibit a memory‐like adaptive response has come from studies involving mouse cytomegalovirus (MCMV) infection. NK cells play a crucial role in the protective immune response to herpesvirus family members, especially to CMV infection. It have been shown that a subset of NK cells in the C57BL/6 strain of mice bearing the activating receptor Ly49H, specifically recognize the MCMV‐expressed ligand m157 and proliferate in response to viral infection [85–87]. Ly49H, a germ‐line encoded receptor, is expressed by a very large fraction of NK cells in naïve mice (~50% of NK cells). During viral infection, a Ly49H‐expressing subset of NK cells is extended and rapidly responds upon reinfection with MCMV, similar to classic lymphocytes memory. The germ‐line encoded MCMV‐specific receptors exist too in mouse strains, such as Bagg Albino (BALB/c), non-obese diabetic (NOD) and others, and that clonal expansions of MCMV‐specific NK cells could also be observed in those strains [88]. Similar to CD8+ T cell response, the proliferation was Ag‐specific because infection of mice with a mutant MCMV lacking m157 did not cause expansion of Ly49H+ NK cells [25]. Ly49H+ NK cells adoptively transferred in mice lacking functional Ly49H receptor proliferate 100‐1000‐fold after MCMV infection, and after a contraction phase, persist for months. When these cells are restimulated
In human, studies have focused on the memory NK cell response in infection with cytomegalovirus (CMV), Hanta virus or Chikungunya virus [90–92]. The results shown that NK cells that express the germ‐line encoded NKG2C receptor appeared in increased frequency in response to infections with these viruses. During acute HCMV infection, NKG2C+ NK cells expanded in number, and diminished partially in numbers after the resolution of the acute phase. These memory NK cells persisted for up to a year. After expansion, the NKG2C+ NK cells produced significantly more IFN‐γ in response than NKG2C- NK cells. A follow‐up study demonstrated that after adoptive transfer of NKG2C+ NK cells from CMV‐seropositive donors exhibited enhanced effector function against a secondary CMV challenge [93]. In the Hanta virus infection or Chikungunya virus infection, NKG2C+ NK cells expanded three‐ to fourfold compared to uninfected controls. In both cases, these increases were only seen in patients who were HCMV seropositive, raising the possibility that the increase in NKG2C+ NK cells reflected reactivation of latent CMV. It has been noted that in HCMV‐infected patients, after the acute infection was cleared, NKG2C+ NK cell numbers remained elevated in contrast with uninfected individuals. It is possible that these NKG2C+ NK cells present in HCMV‐seropositive individuals respond to other infections. Another study has demonstrated that the combination of CMV‐infected fibroblasts plus IL‐12‐producing monocytes induced the expansion of NKG2C+ NK cell in vitro [94].
Memory‐like NK cells could be induced in vitro by cytokines activation in both mice and humans. NK cells from Rag 1‐deficent mice were pre‐activated overnight in vitro with IL‐12, IL‐18 and IL‐15, and then adoptively transferred into syngeneic Rag‐1-/- recipients. After resting in vivo, when the NK cells had reverted to a quiescent state, the cytokine pre‐activated NK cells were phenotypically similar to control NK cells. They expressed similar levels of CD69, CD11b, CD27, B220, as well as the cytokine receptors CD122, IL12Rβ1, IL‐15Rα and CD127. Also, they expressed comparable levels of granzyme B and lysed target cells similar to control NK cells in vitro [27, 95]. However, up to 3 weeks following adoptive transfer, the cytokine pre‐activated NK cells were found to respond more robustly compared to resting NK cells. These pre‐activated NK‐cells displayed enhanced IFN‐γ production upon either activating receptor ligation (Ly49H or NK1.1 receptors) or cytokines (IL‐12 and IL‐15) restimulation. This enhanced ability to produce IFN‐γ occurs in cells that have not undergone division and those that have replicated. It has been demonstrated that the enhanced functionality of memory‐like NK cells is not due to alteration in IFN‐γ transcription or mRNA stability.
\nAdoptively transferred cytokine pre‐activated NK cells proliferated rapidly in an IL‐2‐dependent manner into recipient mice bearing MHC class I‐deficient RMA‐S lymphoma or B16‐Rae1ε melanoma cell lines [96]. Exposure of NK cells to cytokines upregulated the IL‐2Rα chain, making these cells more responsive to IL‐2. It was observed a significantly reduced tumor growth and prolonged survival in recipient mice, pre‐activated NK cells exhibited enhanced functionality months following adoptive transfer, and were able to mediate more effective in vivo antitumor responses.
\nHuman NK cells also exhibit enhanced IFN‐γ production after short‐term pre‐activation with various combinations of IL‐12, IL‐15 and IL‐18 [97]. Both NK cell subsets, CD56bright and CD56dim, exhibited cytokine‐induced memory‐like NK cell. Cytokine pre‐activation led to extensive proliferation, and memory‐like NK cells maintained their capacity for enhanced recall responses. Similar to mice, IFN‐γ mRNA transcript levels did not differ between control and memory‐like NK cells. In contrast to murine memory‐like NK cells, phenotypic differences were identified between pre‐activated NK cells and controls. Human memory‐like NK cells had increased CD94, NKG2A, NKp46 and CD69 surface expression and reduced KIR and CD57 expression. Human memory‐like NK cells were also shown to be responsive to low concentrations of IL‐2.
\nA pre‐clinical study has shown that human memory‐like NK cells also have potential as anti‐leukemia cellular therapy [98]. They exhibited enhanced IFN‐γ production and increased cytotoxicity when restimulated with leukemia cell lines or acute myeloid leukemia (AML) blasts in vitro. Following adoptive transfer into immunodeficient NOD‐severe combined immunodeficiency (SCID)‐γc-/- mice, human cytokine‐induced memory‐like NK cells exhibited increased IFN‐γ production following restimulation [99].
\nTherefore, human NK cells can acquire memory‐like properties after a brief cytokine pre‐activation.
Although, the concept of NK cell memory is rather new, many studies in recent years have provided substantial evidence for adaptive features of the NK cell response. The enhanced function of memory NK cells makes them an area of interest for future use in preventing or treating inflammatory diseases, infectious diseases and cancer.
This work was supported by grand of the Romanian National Authority for Scientific Research (PN 16.22.04‐04).
Reduce, reuse, recycle – this is the current strategy to prevent the world from being flooded by plastic waste. There are many initiatives led by governments, regulators, and also companies and entrepreneurs to follow these guidelines: the so-called “Single Use Plastics” Directive (SUP) [1]. The Circular Plastics Alliance, and The Alliance to End Plastic Waste – to name a few. Incineration and energy recovery of plastics seem to no longer be the promoted solution due to increasing carbon dioxide emissions and causing the loss of the potential hidden within polymers. Although landfilling of plastics practically does not emit CO2, it can lead to microplastic release into the environment [2].
Chemical recycling is now more recognised as a potential solution to recycling or ending the life of plastic, as it can potentially treat the waste that cannot be mechanically recycled, keeping “carbon” in the industry loop. But there is no one official understanding of the term “chemical recycling” worldwide. European regulation defines recycling only at a very general level as any operation that takes waste and makes products, materials, and substances, except fuel components [3]. ISO 15270 is even more precise, limiting chemical (feedstock) recycling to cracking, gasification and depolymerisation processes to convert plastic waste into monomer of new raw materials, excluding energy recovery and incineration [4]. On the other hand, American Chemistry Council (ACC) defines chemical (advanced) recycling as any technology that converts post-use plastics into monomers, specialty polymers, feedstocks and fuels [5]. What is more, the process of waste to value-added chemicals is also known as upcycling [6].
Recycling itself, both mechanical or chemical, can produce two types of products. Suppose the properties of the recycled material are not considerably different from those of the virgin material and can be used in the same application. In that case, the recycling process is called “closed-loop recycling”. This approach is difficult for the mechanical recycling of some polymers for specific applications (like food packaging or specialty applications) as, in many cases, the processing of plastic waste causes partial degradation of the polymer structure and a change to its mechanical properties. When recycled material has different properties and is used in different applications to the original one, the recycling process is called “open-loop”.
In the current chapter, both types of chemical recycling technologies of polyolefins (polyethylene and polypropylene) – closed-loop and open-loop, will be described.
Polyethylene (PE) and polypropylene (PP) are polymers called polyolefins. These are the two largest plastic resins based on production worldwide. One of the reasons for this is the variety of applications where these plastics are used: mainly in packaging but also in toys, piping, cable covers, automotive parts, ship ropes or even bulletproof vests. Polyolefins are inert, have low thermal conductivity (are good insulators) and are not subject to attack by most chemicals. As thermoplastic resins, most polyolefins can be mechanically recycled; however, thanks to the chemical and hydrocarbon structure, they are also proper materials for chemical recycling via cracking (pyrolysis) and gasification.
Polyethylene is a product of ethylene polymerisation. Depending on the production process and consequent chemical structure and properties, many types of PE are produced. The major ones are:
low-density polyethylene (LDPE),
high-density polyethylene (HDPE),
linear low-density polyethylene (LLDPE),
crosslinked polyethylene (PEX).
LDPE is a type of polyethylene with the most branched structure and a density lower than that of HDPE. HDPE is a polymer with a linear structure with a low degree of branching. LLDPE is produced by the polymerisation of ethylene with other olefins with longer hydrocarbon chains, like 1-butene, 1-hexene or 1-octene. The result, a linear backbone with short and uniform branches. Finally, PEX is a polymer obtained by crosslinking the process of polyethylene. This crosslinking changes the properties of polyethylene significantly – increased temperature, pressure, or corrosion resistance. Thermoplastic polyethylene becomes thermoset which limits the possibility of mechanical recycling of this material significantly.
Polypropylene is a product of the polymerisation of propylene. It means that every monomer has a methyl side group. Due to the presence of asymmetric carbon atoms in the chain, stereoisomerism is observed for this polymer.
Differences in the structures are presented in Figure 1. These differences influence the polymer’s mechanical properties and the cracking or gasification process conditions, and the composition of products from chemical recycling processes.
Structures of polyethylene and polypropylene.
It should be noted that many different additives are used to change the properties of the polymer during the production of plastic items. For example, pigments and dyes are added to change the colour; glass fibres can be added to alter the mechanical properties of the polymer, and talk is sometimes added to reduce the price of the final goods. Stabilisers (like UV stabilisers), flame retardants, lubricants and plasticisers are other types of additives commonly used in the plastic industry. The quantity of these additives may be vast, from parts of a percent up to 60–70%. What is more, in many cases, polyolefins are used together with other polymers. For example, in multilayer films used for packaging, PE is used together with poly(ethylene terephthalate) (PET). What is more, flexible packaging is often highly printed. The final yield and composition of chemical recycling products will depend on the type and quantity of all of the impurities.
The cracking of polymers is a process where long polymer chains are broken into products with shorter chains. During heating (at around 350–600°C), molecules start to vibrate until the vibrations are intense enough to overcome van der Waals forces. The short-chain molecules then evaporate. When the energy of the van der Waals force is higher than the enthalpy between carbon atoms in the molecule, the bond in the molecule will break instead of evaporating. In polyolefins’ chains, the most unstable bonds will be the first to break, leading to the creation of radicals. The dissociation energy needed to break the bond between carbon atoms lowers with the order of carbon classification: primary > secondary > tertiary, which means that the first place in a polymer molecule where the bond will break is at the branching. This already indicates that polypropylene cracks at lower temperatures than polyethylene because all carbons in the structure (apart from terminal ones) are tertiary. It also means that LDPE cracks easier than HDPE because of higher branching. All types of polyethylene and polypropylene can be cracked, including those that are challenging for mechanical recycling, like PEX.
In general, the following steps of the cracking reaction can be identified:
initiation – free-radical creation,
propagation – products and secondary radicals creation, isomerisation,
termination – recombination, disproportionation, cyclisation, arenes creation, polycondensation.
When the bond between hydrogen and carbon atom is broken, a radical is created (initiation step). In the second step of the process, polymer bond breaks at the
unzipping – the chain break at the
backbiting – intramolecular transfer of a hydrogen atom from one part of the molecule to the other part of the same molecule and then
random scission – intermolecular transfer of hydrogen atom and then
Cracking of polyolefins by random scission reaction, redrawn from [
In the case of polyolefins, cracking occurs mainly by random scission and backbiting reactions.
In the last step of the process, the radical can react with another radical, creating saturated alkane (recombination), one alkane and one alkene (disproportionation), create cyclic structure (cyclisation), dehydrogenate and condensate and take part in other reactions. In the end, a mixture of different types of hydrocarbons with varying chain lengths is created. When condensation and dehydrogenation reaction progress, polycyclic aromatic hydrocarbons (PAH) are created, which still react and finally create a coke, that is reach in carbon.
As mentioned before, the cracking of polyolefin chains produces different hydrocarbons. In general, three types of streams are created during the pyrolysis of polyethylene and polypropylene: gas fraction that consists of hydrocarbons with the lowest molecular weights, a liquid or semisolid fraction (pyrolysis oil) that consists of hydrocarbons that were created in the form of vapours which after cooling were condensed and the process residue (char), that consists of plastic’s additives and coke, which was created during the process. The composition and yields of each of these products depend on the feedstock’s composition and process conditions such as temperature, pressure, residence time, and catalyst used.
For example, during the process in a rotary kiln reactor with quartz sand used as a heat carrier, pyrolysis oil consisting of 43,1% of aliphatic hydrocarbons and 55,5% of aromatic hydrocarbons were obtained from polyethylene. Pyrolysis oil from polypropylene consisted of 44,7% aliphatic and 52,9% aromatic hydrocarbons [9]. On the other hand, during thermal cracking of PE and PP in a microreactor at different temperatures gave products consisting of 59,7% alkanes, 31,90% alkenes, 8,40% cycloalkanes and 66,55% alkanes, 25,7% alkenes and 7,58% cycloalkanes, respectively. No aromatics were identified [10]. These two examples already indicate how different products can be obtained, depending on the process conditions.
In general, it can be observed that raising the temperature and residence time can increase arenes creation and can also raise the alkane to alkene ratio in the product, for example, in [11]. Aromatics content can also be significantly raised by the use of certain catalysts, like zeolites. The type of catalyst also influences the alkane/alkene ratio [12]. It should be noted that catalysts can be rapidly deactivated, limiting their use in continuous processes [13]. An increase in the temperature can increase the yield of long-chain hydrocarbons due to reduced residence time. However, it can also favour increased gas and lower molecular weight product formation by increasing the number of secondary reactions if the residence time is long enough. The majority of cracking processes are conducted at atmospheric pressures. However, some investigations present that higher pressure can increase the gas formation at lower temperatures, but with the increase of the temperature, the effect was diminished. A decrease of double bonds formation with the pressure increase was also observed [14]. What is more, different polymers can have a synergistic effect on co-pyrolysis [15]. Polystyrene (PS) is also a valuable feedstock for pyrolysis. The product of PS cracking is almost fully aromatic, with styrene monomer as a major product [16]. It can also be co-pyrolysed with polyolefins. Poly(methyl methacrylate) (PMMA) is another polymer that can be pyrolysed [17]. Poly(vinyl chloride) (PVC) produces large quantities of corrosive hydrogen chloride and can contaminate all – gas, liquid, and residue. PET gives low yields of oil, and the thermal cracking of polyurethanes provides products reach in organic nitrogen components [18]. Pyrolysis of biomass converts waste into oil with high oxygen content and increase coke formation [19]. That is why most of the research and developed technologies are based on polyolefins, optionally with the addition of polystyrene, while other plastics and biomass are treated as impurities.
Pyrolysis of plastics is a complex process with many variables that produce hydrocarbons from polyolefin feedstock. It makes the process difficult but flexible at the same time. That is why many different solutions are used (other types of reactors), but also different product types for different applications are obtained.
As described in the previous section, cracking of polyethylene and polypropylene can lead to many different products. The composition of the products – hydrocarbon type and chain length – will determine their application.
Pyrolysis oil obtained during thermal or thermocatalytic cracking of polyolefins is a complex mixture of hydrocarbons with different chain lengths (5 to 30 and more carbon atoms). Linear and branched paraffins and olefins, together with aromatics: mono and polyaromatics – with and without aliphatic side chains, are obtained. Such a complex mixture does not have a direct application without additional treatment. However, as a hydrocarbon product, it can be mixed with refinery and petrochemical streams and processed together with crude. The process is simple, consisting of only a cracking reactor, product cooling system, residue discharge system and gaseous product burning unit (for energy production).
However, the capacity of commercial chemical recycling plants is limited due to plastic waste availability and the process itself – polymers have a low thermal conductivity which makes the scale-up of the pyrolysis reactor challenging. The biggest pyrolysis plants have a capacity of about 100 000 tons per year which is very small compared to the standard refinery size of about 4–10 million tons per year. This means that the recycled stream is highly dissolved in the refinery. As a result, the product can be contaminated, so there is no need for expensive detailed sorting and washing of the plastic waste or purification of the pyrolysis oil. Even though this makes the process much cheaper, the solution is not economically feasible.
Cracking is an endothermic process that requires a lot of energy to melt the plastic and break polymer bonds, as plastics are excellent insulators. The residue obtained from cracking is usually a high-calorific by-product and contains a high level of contamination, limiting its use in incinerators, especially if the raw material used for pyrolysis was not properly separated and cleaned. For example, the presence of PVC significantly raises the chlorine content, which is limited in incinerators’ feedstock specifications. Special treatment of this residue increases the overall cost of operations.
Pyrolysis of plastic waste into feedstock for refineries was very popular a couple of years ago. For example, in Poland until 2007, many commercial (Technology Readiness Level, TRL = 9) plants were operated, but their profitability was based on relief in excise tax. When regulation changed, they were all bankrupted. Low prices of crude oil caused the closure of other companies worldwide, or they changed their profile. For example, Agilyx from the US had to shut down its flagship plant in Tigard in 2016, later changing its activity profile to polystyrene recycling [20].
The most popular application for products from the chemical recycling of polyethylene and polypropylene are fuels and fuel components. Hydrocarbon product can be separated into more narrow fractions like gasoline, diesel, light and heavy fuel oil. Hydrocarbons with the highest molecular weights (waxes) can be circulated back to the cracking reactor or cracked in an additional catalytic process. Proper process parameters can also limit the quantity of waxy hydrocarbons, but it usually causes high gas yields. Pyrolysis reactors are followed by distillation units. The ratio between different products depends on technology. An example of two companies’ products slates are presented in Table 1 [21].
Type of product | Cynar | PK Clean |
---|---|---|
Kerosene, % | 10 | — |
Diesel, % | 70 | 66 |
Light fuel oil/Naphtha, % | 20 | 33 |
Wax, % | — | re-circulated |
Product slate examples [21].
From one side, fuels obtained from the pyrolysis of polyolefins are characterised by low concentrations of sulphur (less than 0,1%) and are easily burned as hydrocarbon fractions. On the other hand, high olefin content reduces oxidation stability. Furthermore, reactive alkenes relatively easily undergo polymerisation reaction creating gums with high molecular weights. That is why products from PE and PP cracking should not be stored for a longer time. This tendency to polymerisation can also cause issues in distillation units where resins deposit at surfaces of elevated temperatures, reducing heat transfer coefficient in heaters and heat exchangers, also plugging the distillation columns and reducing mas flow in these units. Foaming during distillation is also observed [22, 23].
Hydrotreatment (catalytic reactions with hydrogen) of the products from pyrolysis could be a solution – olefins can be saturated into paraffins, stabilising the product. But it would raise the total cost of the process as it usually carries out at elevated pressures and requires special, separate units. What is more, products reach in linear paraffins may have high pour point of diesel and light fuel oil fractions. Unsuitable gasoline fraction octane number and cold-temperature behaviour of heavier fractions limit their use in combustion. To keep proper fuel parameters, blends of hydrotreated fractions from chemical recycling of plastics and commercial fuels can be prepared. But to keep proper parameters, a maximum of 1% of gasoline fraction, 10% of diesel fraction and 20% of light fuel fraction from polyolefins’ cracking can be used [24]. If the process is controlled to produce a highly aromatic product, then higher octane gasoline and lower cetane diesel could be obtained.
Fuels and fuel components obtained from plastic waste compete in price with fossil fuels, making the profitability of the process challenging. Also, this type of application in European regulation is seen as energy recovery, so it is not considered chemical recycling. Nevertheless, there are several companies that are focused on the production of fuels. For example, Bightmark Energy is building a 100 000 t/a commercial facility (TRL 9) in Ashley (US), which is planned to be commissioned in 2021. Braven Environmental is planning a 65 000 t/a plant in Virginia. Nexus Fuels commercial-scale plant’s capacity is 50 t/d, similar to one module of Integrated Green Energy Solutions’ plant constructed in Amsterdam. Polish company Handerek Technologies develops technology for fuels production by pyrolysis of plastics and further hydrotreatment at atmospheric pressure, using syngas (mixture of hydrogen and carbon oxide). The process at an early stage of commercialisation, presenting only a small scale pilot plant (TRL 4–5) with plans to build commercial plants with a capacity of 10 000 t/a.
The production of monomers that would be firther used for polymerisation could be the only solution for closed-loop recycling of PE and PP waste. Depolymerisation of polyolefins is not easy as bonds between carbon atoms in the chain are relatively strong. As described before, thermal or thermocatalytic cracking leads to a mixture of hydrocarbons with different chain lengths. Gas fraction is produced, but alkenes content in it is usually low. A research was conducted to maximise the gas fraction and olefin content, but the highest ethylene concentration in the gas stream achieved was 25%. Still, a minimum of 40% of liquid product was obtained [7]. In other research, steam was used in a fluidised bed reactor for pyrolysis of plastic waste to maximise olefin yields. 20–31% ethene and 14–18% propene were obtained. Additionally, 19–23% gasoline was produced. These yields are similar to standard naphtha steam cracker’s product, but the research was run at lab-scale, and no information about scale-up is available [25].
The most extensively investigated process currently is the production of feedstock for commercial steam crackers. Plastic waste is cracked thermally or catalytically into a liquid fraction with proper boiling range and further mixed with fossil feedstock. Some research presented that it would be possible to use liquid from plastic pyrolysis only, receiving results similar to use naphtha [26]. But to avoid coking of the colder section of the steam cracking reactor and contamination of created streams with heteroatoms present in pyrolysis oils, co-cracking with standard feeds is preferred. Purification of the pyrolysis oil by hydrotreatment upfront steam cracking could be a solution that increases the total cost of the process. Considering the capacities of chemical recycling plants and current steam crackers (millions of tons of ethylene), significant dissolution of pyrolysis oil in fossil-based feedstock might be a solution for this issue, as pyrolysis oil can be only a small part of the inlet stream to the steam cracker.
Although making monomers and then polymers from polyolefin waste look like a very promising route for closed-loop recycling of polyethylene and polypropylene, several concerns should be considered. First, the basic question mark is about yields of the process. If it is assumed that pyrolysis oil has similar properties to commercial naphtha, then yields of ethylene and propylene that can be used for further polymerisation is limited, as presented in Table 2 [27]. In the case of higher boiling fractions (like gasoil or diesel fraction) or oils reach in branched or aromatic hydrocarbons, yields of ethylene and propylene are lower, and the yield of liquid products rises [28]. These products can be used as feedstock for chemical processes but are currently used primarily as fuels, which is not considered as recycling according to European regulations.
Product | % wt. |
---|---|
Residual gas (methane, hydrogen) | 16,0 |
Ethylene | 35,0 |
Propylene | 15,0 |
C4 fraction | 8,5 |
Fraction >C4 (C5, pyrolysis gasoline, residual oil) | 25,5 |
Products of steam cracking of naphtha [27].
As the plastic-based liquid has to be blended with naphtha or other steam cracking fossil-based feeds, it is challenging to trace the flow of materials along the supply chain. For that purpose, a mass balance accounting system is required. It is a set of rules for allocating the recycled content to different products in order to be able to claim the recycled content. Products can be accredited by the independent scheme, for example, the International Sustainability and Carbon Certification Plus (ISCC) scheme. NGOs challenge the currently used calculation method as requiring more clarification and a more strict approach as it can be misused, claiming incorrect recycled contents [29]. It is understandable as long as detailed and correct data is not shared. For example, in one of the published Life Cycle Assessments (LCA) for the process, the considered amounts of naphtha from chemical recycling that is needed to produce 1 kg of LDPE were 1,2–2,0 kg with the baseline of 1,5 kg of naphtha per 1 kg of LDPE produced. These numbers are not in line with ethylene yields from fossil naphtha (as presented in Table 2) and require a broader explanation [30].
The final consideration is about the overall environmental impact of the process. For evaluating the influence of the process or product, a systematic analysis of the environmental impacts, called Life Cycle Assessment (LCA), is used. Currently, only two executive summaries of LCA were published, which were also criticised by NGOs [31]. As not enough data is publicly available, it is difficult to evaluate these concerns. What is sure, the process chain is very long and complex, as presented in Figure 3, and requires the use of fossil-based feedstocks and only part of the plastic pyrolysis oil is converted back to a polymer. The yield of the fraction that can be processed in a steam cracker in the plastic pyrolysis process is unknown. In this case, LCA analysis should consider yields and processing of other products from plastic pyrolysis and steam cracking to present the whole impact. Lastly, the feasibility of these processes are a matter of concern, especially if hydrotreatment is used for pyrolysis oil purification.
Scheme of polyethylene and polypropylene from the plastic waste production process.
Currently, big polyolefin producers are involved in projects for the chemical recycling of plastics into monomers, like BASF, SABIC, Borealis or Chevron Philips Chemical, cooperating with companies experienced in pyrolysis, like Plastic Energy, Quantafuel or Nexus Fuels. In Geleen, the Netherlands, a plant for cracking of polyolefins is constructed and a hydrotreating system for purification of pyrolysis oil, which will later be fed to a steam cracker. This project is a joint investment of Plastic Energy and SABIC [32]. The plant is expected to have a capacity of 15–20 000 t/a and to become operational in 2022.
The production of valuable chemicals from waste, called upcycling, is an interesting alternative. The mixture of hydrocarbons obtained from polyolefins’ pyrolysis can be upgraded or separated into different hydrocarbon types. What is more, the flexibility of the cracking process enables the maximisation of target fractions.
The major advantage of plastic-to-chemicals processes is that most of the proposed solutions offer final market products that do not require further processing in petrochemical plants. In this case, a mass balance approach is not required as products are based entirely on plastic waste. As products are not dedicated to be burned for energy production, these technologies can be classified as open-loop recycling also under European regulations. What is more, special, niche applications enable higher margin than compared to naphtha or fuel. On the other hand, these applications are limited when products are produced from waste, require high purity (virgin) polymers or complex pre- or post-treatment and purification, which may significantly influence the feasibility.
Benzene, toluene and xylenes (BTX) are important aromatics used by petrochemical industry to produce valuable chemicals like polystyrene, nylons, methacrylates, polyurethanes, plasticisers and many more. The pyrolysis process of polyethylene and polypropylene can be controlled to maximise aromatic hydrocarbons. A presence of polystyrene in the raw material could increase yields of BTX fraction. Nevertheless, it is possible to obtain 53% and 32% BTX from PP and PE, respectively [33, 34, 35]. These aromatics have to be further separated from the pyrolysis oil.
Encina from the US is an example of a company that provides a technology of catalytic cracking for BTX and propylene production but is currently not at a commercial scale. The planned unit will produce about 90 000 t/a of chemicals [36].
Polyolefin waxes can also be produced by the cracking of polymers. These kinds of waxes are widely used in PVC production, surface modifiers, additives to other waxes etc., and can be produced as a by-product of polyolefins production. Some companies, like Mitsui Chemicals America, Hana Corp., EPChem or Merlob, crack virgin polymers for the purpose of wax production. In this case, an issue of contamination by additives does not exist. If polyolefin wastes are considered, then a proper purification process should be implemented, or the application range would be significantly limited to those where colour and presence of inorganics is not an issue.
GreenMantra Technologies from Canada produces waxes by catalytic pyrolysis of plastic wastes at elevated pressure (4,5–25 bar). Wax products under the name of Ceranovus can be used for bitumen and asphalt modification, polymer processing or adhesives production. As an addition, fuel oil is produced. The current plant (TRL 9) has a capacity of 5 000 t/a [37]. Another company producing waxes (“EnviroWax”) from plastic waste through pyrolysis is Trifol from Ireland. The by-products are fuels: diesel/kerosene and naphtha. The company has a pilot plant (TRL 6–7) with plans for scale-up to 37 000 t/a [38].
Clariter carries out the most complex process for plastic waste conversion into chemicals. Aliphatic solvents (“Solventra”), white oils (“Oilter”) and paraffin waxes (“Clariwax”) of high purity are produced from polyolefin waste via thermal cracking, hydrotreatment, and distillation and are alternatives to similar fossil-based products available in the market (Figure 4). To maximise on profit, target products are deeply purified from heteroatoms and hydrogenated so they can potentially be used in the cosmetic industry. Other applications are: paints, inks, degreasers, wax emulsions, paper and wood impregnation, lubrication, car or furniture polishes, silicone sealants and others. The company owns a pilot plant in Poland (TRL 5) and an Industrial-scale Plant in South Africa (TRL 7) with scale-up plans for 60 000 t/a facilities. Most interestingly, the company claims to achieve a net negative carbon footprint which is unique compared to other LCA’s published [39].
Clariter products.
Gasification is a well-established process for the conversion of many non-renewable sources, like petroleum resids, petcoke or coal. In general, it can process any carbonaceous material into a valuable mixture of hydrogen, carbon monoxide and carbon dioxide – called syngas (synthetic gas). Syngas itself is a source of hydrogen and carbon monoxide used for various chemical processes or as fuel when separated into pure streams, or as a high calorific fuel or feedstock for chemical synthesis into other chemicals, like methanol, ethylene glycol, acetic anhydride and hydrocarbons (via Fischer-Tropsch synthesis) when not separated. Examples of syngas applications are presented in Figure 5. As polyolefins consist of carbon and hydrogen, these can be very good feedstock for gasification.
Overview of potential syngas applications [
Gasification is a complex process with several reactions taking place between carbon-based material, oxygen and steam at high temperatures (700–1500°C). Examples of reactions that take place during gasification are presented in Table 3.
Reaction | ΔH, kJ/mol |
---|---|
Primary reactions | |
+118,9 | |
+160,9 | |
−87,4 | |
−246,3 | |
Secondary reactions | |
−42,3 | |
−205,8 |
Examples of gasification process reactions [28].
The hydrogen to carbon oxide ratio in obtained syngas varies significantly (from 0,7 to 6 for different fossil fuels) depending on the type of the raw material and technology. For different applications, different ratios are required. It is technically possible to obtain every required syngas composition from every feedstock, but it has economic limitations [28].
Polyolefin waste is potentially a very good source of carbon for gasification. What is more, as biomass and other plastic wastes are also reach in carbon, mixed wastes streams can be used. Gasification of waste has the following steps: drying, pyrolysis, cracking and reforming, char gasification. Drying of plastics has an insignificant role but might be important when plastics are processed with biomass, unlike the pyrolysis step, which is key in the gasification of plastics. The poor heat conductivity, sticky nature, high content of volatiles created during pyrolysis of polyolefins, and relative low char and high tar yields make the process different from coal or biomass gasification challenging but also promising. Air and steam gasification processes are proposed with different pros and cons. Finally, co-gasification with fossil-based feedstock or other waste streams is possible, expanding the flexibility of the process. The variability of quality and composition of the feedstock is a significant problem [40].
Gasification seems to be a promising alternative to pyrolysis for chemical recycling of plastic waste, which can produce chemicals or fuels without detailed separation and washing of the feedstocks. It is attractive due to the versatility of potential products. On the other hand, it is related to high capital and operational costs [41]. What is more, currently, only fuels are produced, which might be related to instability of the waste streams, which may cause problems with keeping proper hydrogen to carbon oxide ratio.
Canadian company Enerkem provides the most advanced waste pyrolysis technology. The company currently operates a commercial (TRL 9) plant in Edmonton with a capacity of 38 000 m3/a of methanol and ethanol used as a fuel. Another plant in Canada for fuels and chemicals production with a capacity of 125 000 m3/a is under construction, and two more projects with capacities of 270 000 m3/a of methanol each are developed currently in Europe [42]. Ebara Environmental Plant and Ube Industries from Japan provide gasification of plastic waste through partial oxidation by oxygen and steam. 70 000 tons of plastic waste is processed at Showa Denko’s Kawasaki Plant since 2003. Currently, a feasibility study for the next plant in South Korea is being processed [43].
Chemical recycling of polyethylene and polypropylene gained much attention over the last years due to the rising plastic waste issue. Many projects of demonstration or commercial facilities are currently being developed. Although the definition of chemical recycling is inconsistent worldwide, four main types of products can be identified: intermediates for further chemical processing, fuels and fuel components, monomers and final chemical products. Pyrolysis and gasification are processes that can be used for polyolefins providing mainly open-loop recycling solutions. These technologies require deep feasibility and environmental impact analyses due to their complexity, different values of products, need for co-processing with fossil-based feedstock or high capital cost. Nevertheless, intensive growth of plastic waste volumes is an opportunity for these technologies to be further developed, optimised and commercially used.
The author declares no conflict of interest.
This review is dedicated to Dr. Mieczysław Steininger’s (1950–2021) memory, a well-respected academic, extraordinary scientist and wonderful mentor. On behalf of the Clariter Board, Management, all the staff and especially myself, I would like to thank you for all the research, involvement, impact and inspiration of your extraordinary mind and charming personality.
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To ensure optimal human-robot collaboration, these tools are seamlessly integrated into the command and control equipment of the human crisis managers and a set of training and support tools is provided to them to learn to use the ICARUS system.",book:{id:"6181",slug:"search-and-rescue-robotics-from-theory-to-practice",title:"Search and Rescue Robotics",fullTitle:"Search and Rescue Robotics - From Theory to Practice"},signatures:"Geert De Cubber, Daniela Doroftei, Konrad Rudin, Karsten Berns,\nAnibal Matos, Daniel Serrano, Jose Sanchez, Shashank Govindaraj,\nJanusz Bedkowski, Rui Roda, Eduardo Silva and Stephane Ourevitch",authors:[{id:"206420",title:"Dr.",name:"Geert",middleName:null,surname:"De Cubber",slug:"geert-de-cubber",fullName:"Geert De Cubber"}]},{id:"5974",doi:"10.5772/6475",title:"Autonomous Formation Flight: Design and Experiments",slug:"autonomous_formation_flight__design_and_experiments",totalDownloads:4474,totalCrossrefCites:14,totalDimensionsCites:16,abstract:null,book:{id:"3696",slug:"aerial_vehicles",title:"Aerial Vehicles",fullTitle:"Aerial Vehicles"},signatures:"Yu Gu, Giampiero Campa, Brad Seanor, Srikanth Gururajan and Marcello R. Napolitano",authors:null}],mostDownloadedChaptersLast30Days:[{id:"56737",title:"UAV for Landmine Detection Using SDR-Based GPR Technology",slug:"uav-for-landmine-detection-using-sdr-based-gpr-technology",totalDownloads:3326,totalCrossrefCites:12,totalDimensionsCites:14,abstract:"This chapter presents an approach for explosive-landmine detection on-board an autonomous aerial drone. The chapter describes the design, implementation and integration of a ground penetrating radar (GPR) using a software defined radio (SDR) platform into the aerial drone. The chapter?s goal is first to tackle in detail the development of a custom-designed lightweight GPR by approaching interplay between hardware and software radio on an SDR platform. The SDR-based GPR system results on a much lighter sensing device compared against the conventional GPR systems found in the literature and with the capability of re-configuration in real-time for different landmines and terrains, with the capability of detecting landmines under terrains with different dielectric characteristics. Secondly, the chapter introduce the integration of the SDR-based GPR into an autonomous drone by describing the mechanical integration, communication system, the graphical user interface (GUI) together with the landmine detection and geo-mapping. This chapter approach completely the hardware and software implementation topics of the on-board GPR system given first a comprehensive background of the software-defined radar technology and second presenting the main features of the Tx and Rx modules. Additional details are presented related with the mechanical and functional integration of the GPR into the UAV system.",book:{id:"5905",slug:"robots-operating-in-hazardous-environments",title:"Robots Operating in Hazardous Environments",fullTitle:"Robots Operating in Hazardous Environments"},signatures:"Manuel Ricardo Pérez Cerquera, Julian David Colorado Montaño\nand Iván Mondragón",authors:[{id:"177422",title:"Dr.",name:"Julian",middleName:null,surname:"Colorado",slug:"julian-colorado",fullName:"Julian Colorado"},{id:"197884",title:"Prof.",name:"Ivan",middleName:null,surname:"Mondragon",slug:"ivan-mondragon",fullName:"Ivan Mondragon"},{id:"199958",title:"Prof.",name:"Manuel",middleName:null,surname:"Perez",slug:"manuel-perez",fullName:"Manuel Perez"}]},{id:"67705",title:"Advanced UAVs Nonlinear Control Systems and Applications",slug:"advanced-uavs-nonlinear-control-systems-and-applications",totalDownloads:1899,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Recent development of different control systems for UAVs has caught the attention of academic and industry, due to the wide range of their applications such as in surveillance, delivery, work assistant, and photography. In addition, arms, grippers, or tethers could be installed to UAVs so that they can assist in constructing, transporting, and carrying payloads. In this book chapter, the control laws of the attitude and position of a quadcopter UAV have been derived basically utilizing three methods including backstepping, sliding mode control, and feedback linearization incorporated with LQI optimal controller. The main contribution of this book chapter would be concluded in the strategy of deriving the control laws of the translational positions of a quadcopter UAV. The control laws for trajectory tracking using the proposed strategies have been validated by simulation using MATLAB®/Simulink and experimental results obtained from a quadcopter test bench. Simulation results show a comparison between the performances of each of the proposed techniques depending on the nonlinear model of the quadcopter system under investigation; the trajectory tracking has been achieved properly for different types of trajectories, i.e., spiral trajectory, in the presence of unknown disturbances. Moreover, the practical results coincided with the results of the simulation results.",book:{id:"7792",slug:"unmanned-robotic-systems-and-applications",title:"Unmanned Robotic Systems and Applications",fullTitle:"Unmanned Robotic Systems and Applications"},signatures:"Abdulkader Joukhadar, Mohammad Alchehabi and Adnan Jejeh",authors:null},{id:"60953",title:"Small to Medium UAVs for Civilian Applications in Indonesia",slug:"small-to-medium-uavs-for-civilian-applications-in-indonesia",totalDownloads:1317,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Indonesian government needs a well-built, easy to operate unmanned aircraft systems (UAS) to perform various civilian missions as UAS are a well-known platform for dirty, dull, and dangerous missions. Hence, the Indonesian government has an organization that performs research and development of UAS, named as Aeronautic Technology Center. This organization is placed underneath Indonesian National Institute of Aeronautics and Space. The UAS developments in this institute are primarily driven by civilian uses; therefore, the UAS size, sensor types, and mission payload are optimized for civilian missions. In order to produce the decent to the best quality of the aerial image, which is the essential product for various civilian missions, the UAS regularly flies under the cloud. For this reason, the Aeronautic Technology Center is only developing the LASE (low altitude, short-endurance) and the LALE (low altitude, long endurance) UAS type as of now. The UAS development was begun with LSU-01, followed by LSU-02, LSU-03, and LSU-05. The LSU-01, LSU-02, and LSU-03 are in the operational phase, while the LSU-05 is in the experimental Phase. In this chapter, the specification of the platforms and the sensor capabilities that are relevant with the demands of users in the civilian sector are described.",book:{id:"6465",slug:"drones-applications",title:"Drones",fullTitle:"Drones - Applications"},signatures:"Fuad Surastyo Pranoto, Ari Sugeng Budiyanta and Gunawan Setyo\nPrabowo",authors:[{id:"223333",title:"M.Sc.",name:"Fuad",middleName:"Surastyo",surname:"Pranoto",slug:"fuad-pranoto",fullName:"Fuad Pranoto"},{id:"223356",title:"MSc.",name:"Ari Sugeng",middleName:null,surname:"Budiyanta",slug:"ari-sugeng-budiyanta",fullName:"Ari Sugeng Budiyanta"},{id:"223357",title:"MSc.",name:"Gunawan Setyo",middleName:null,surname:"Prabowo",slug:"gunawan-setyo-prabowo",fullName:"Gunawan Setyo Prabowo"}]},{id:"67003",title:"Vision-Based Autonomous Control Schemes for Quadrotor Unmanned Aerial Vehicle",slug:"vision-based-autonomous-control-schemes-for-quadrotor-unmanned-aerial-vehicle",totalDownloads:942,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"This chapter deals with the development of vision-based sliding mode control strategies for a quadrotor system that would enable it to perform autonomous tasks such as take-off, landing and visual inspection of structures. The aim of this work is to provide a basic understanding of the quadrotor dynamical model, key concepts in image processing and a detailed description of the sliding mode control, a widely used robust non-linear control scheme. Extensive MATLAB simulations are presented to enhance the understanding of the controller on the quadrotor system subjected to bounded disturbances and uncertainties. The vision algorithms developed in this chapter would provide the necessary reference trajectory to the controller enabling it to exercise control over the system. This work also describes, in brief, the implementation of the developed control and vision algorithms on the DJI Matrice 100 to present real-time experimental data to the readers of this chapter.",book:{id:"7792",slug:"unmanned-robotic-systems-and-applications",title:"Unmanned Robotic Systems and Applications",fullTitle:"Unmanned Robotic Systems and Applications"},signatures:"Archit Krishna Kamath, Vibhu Kumar Tripathi and Laxmidhar Behera",authors:null},{id:"59130",title:"The Use of Unmanned Aerial Vehicles by Urban Search and Rescue Groups",slug:"the-use-of-unmanned-aerial-vehicles-by-urban-search-and-rescue-groups",totalDownloads:1247,totalCrossrefCites:5,totalDimensionsCites:6,abstract:"In the case of natural or man-made disaster, the top priority of urban search and rescue (USAR) groups is to localise the victim as quickly as possible. Even minutes might play a crucial role in the victim’s survival. A number of standard operating procedures may be applied to achieve best performance. Rescue dogs are trained to search for alive victims; special inspection cameras are used, before heavy equipment is being implemented. To improve the effectiveness of USAR group operations, innovative technologies might be implemented. The most recent solution is currently designed in MOBNET project, founded by EU under the Horizon 2020 programme. The scope of the project is to combine both cellular technology and early Galileo services to localise the smartphones of potential victims. Integration tests give some promising outcomes. The following chapter looks at typical applications, real needs of public services as well as the performance of the novel system.",book:{id:"6465",slug:"drones-applications",title:"Drones",fullTitle:"Drones - Applications"},signatures:"Marzena Półka, Szymon Ptak, Łukasz Kuziora and Aneta Kuczyńska",authors:[{id:"226977",title:"Dr.Ing.",name:"Szymon",middleName:null,surname:"Ptak",slug:"szymon-ptak",fullName:"Szymon Ptak"},{id:"240085",title:"Prof.",name:"Marzena",middleName:null,surname:"Półka",slug:"marzena-polka",fullName:"Marzena Półka"},{id:"240086",title:"MSc.",name:"Łukasz",middleName:null,surname:"Kuziora",slug:"lukasz-kuziora",fullName:"Łukasz Kuziora"},{id:"240087",title:"MSc.",name:"Aneta",middleName:null,surname:"Kuczyńska",slug:"aneta-kuczynska",fullName:"Aneta Kuczyńska"}]}],onlineFirstChaptersFilter:{topicId:"242",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:43,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. 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He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. 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He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11675",title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",hash:"e1d9662c334dd78ab35bfb57c3bf106e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 19th 2022",isOpenForSubmission:!0,editors:[{id:"281317",title:"Dr.",name:"Fabio",surname:"Iannotti",slug:"fabio-iannotti",fullName:"Fabio Iannotti"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11677",title:"New Insights in Mammalian Endocrinology",coverURL:"https://cdn.intechopen.com/books/images_new/11677.jpg",hash:"c59dd0f87bbf829ca091c485f4cc4e68",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"321396",title:"Prof.",name:"Muhammad Subhan",surname:"Qureshi",slug:"muhammad-subhan-qureshi",fullName:"Muhammad Subhan Qureshi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11676",title:"Recent Advances in Homeostasis",coverURL:"https://cdn.intechopen.com/books/images_new/11676.jpg",hash:"63eb775115bf2d6d88530b234a1cc4c2",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 10th 2022",isOpenForSubmission:!0,editors:[{id:"203015",title:"Dr.",name:"Gaffar",surname:"Zaman",slug:"gaffar-zaman",fullName:"Gaffar Zaman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:4,paginationItems:[{id:"81821",title:"Pneumococcal Carriage in Jordanian Children and the Importance of Vaccination",doi:"10.5772/intechopen.104999",signatures:"Adnan Al-Lahham",slug:"pneumococcal-carriage-in-jordanian-children-and-the-importance-of-vaccination",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"81813",title:"Schistosomiasis: Discovery of New Molecules for Disease Treatment and Vaccine Development",doi:"10.5772/intechopen.104738",signatures:"Andressa Barban do Patrocinio",slug:"schistosomiasis-discovery-of-new-molecules-for-disease-treatment-and-vaccine-development",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:249,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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