Pradeep P.A. Mammen

The University of Texas Southwestern Medical CenterUnited States of America

Mammen Biosketch: Background: Dr. Pradeep P.A. Mammen received a B.S.E. in Bioengineering with a minor in Electrical Engineering at the University of Pennsylvania (1990) and his medical doctorate from the University of Wisconsin-Madison (1995). After completing a residency in Internal Medicine at the University of Iowa Hospitals & Clinics (1998), Dr. Mammen pursued clinical fellowship training at UT Southwestern in General Cardiology (2000) and CHF/VAD/Heart Transplantation (2004) as well as a postdoctoral research fellowship in Molecular Cardiology under the mentorship of Dr. Daniel Garry (2000-2004). Clinical Expertise: Dr. Mammen is a clinician-scientist with clinical expertise in advanced heart failure, ventricular assist devices (VAD) and heart transplantation. From a clinical perspective, Dr. Mammen is one of only approximately 1,000 adult cardiologists in the United States board certified in advanced heart failure/VAD/heart transplantation. Currently, he is an Associate Professor of Medicine at UT Southwestern Medical Center and holds the Alfred W. Harris, M.D. Professorship in Cardiology. Dr. Mammen serves as the Co-Director of the UT Southwestern Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center and the Director for Translational Research for the Advanced Heart Failure and Transplant Cardiology Program at UT Southwestern. Due to additional training he received in molecular cardiology, Dr. Mammen has also developed a unique interest as well as expertise in the care of patients who develop a familial or genetic form of cardiomyopathy (esp. neuromuscular-associated cardiomyopathies). In June of 2010, Dr. Mammen became the founding Medical Director of the UT Southwestern Neuromuscular Cardiomyopathy Clinic. Referrals to this clinic in recent years have exploded (900 patients to date), demonstrating the great clinical need for such a clinic in the community. Finally, he is utilizing this clinic as a platform for translational studies focused on novel therapies directed towards muscular dystrophy patients. These studies are aimed at improving both the overall care as well as the cardiovascular care provided to this unique patient population. Scientific Expertise: In keeping with Dr. Mammen’s clinical interest in the treatment and management of patients with a cardiomyopathy, he has developed significant scientific interest in investigating the molecular mechanisms underlying heart failure and cardiac/skeletal muscle myopathies. Dr. Mammen’s long-term scientific goal is to become a national leader in biomedical innovation and discovery in order to improve the quality and longevity of patients with heart failure, especially as it relates to cardiac/skeletal muscle myopathies. He runs a molecular cardiology laboratory that has been continuously funded by various federal (NIH), private (AHA) and industry (Catabasis Inc., GlaxoSmithKline Research Foundation, and PhaseBio Inc.) granting agencies. In the Fall of 2015, the NIH awarded UT Southwestern one of six Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) in the country and the Center was refunded for another 5 years in 2020. Dr. Eric Olson, Chair of the UT Southwestern Department of Molecular Biology, and Dr. Mammen are the Co-Directors of this Center and were responsible for successfully obtaining this important NIH funding. The core mission of the Center is to rapidly develop genome editing into a viable and effective therapy for patients with Duchenne muscular dystrophy. In addition, Dr. Mammen runs a molecular laboratory focused on mechanistic studies to enhance our understanding of various signaling pathways that contribute to heart failure and cardiac/skeletal muscle myopathies. In particular, his research team is investigating the role of redox signaling to enhance the understanding of myogenesis, muscle regeneration, and cardiac/muscle remodeling. Dr. Mammen’s scientific work positions him perfectly to succeed at functionally integrating the many individuals, including physicians, nurses, scientists and support staff, required to manage a complex entity like the UT Southwestern Wellstone MDSRC. Summary Over the past 17 years, Dr. Pradeep P.A. Mammen has established himself as a talented clinician-scientist who has developed the unique ability to traverse between the clinical and scientific spheres with relative ease. In addition to Dr. Mammen’s clinical acuity and extensive clinical expertise in clinical heart failure/VAD/heart transplantation, his scientific accomplishments have demonstrated that he is capable of undertaking and leading scientific research studies in a highly collaborative and productive manner. Since joining the UT Southwestern faculty Dr. Mammen has successfully administered various grants, formed strong collaborations with several key clinicians and scientists, discovered a novel signaling pathway within myocytes and has produced 68 high-quality peer-reviewed publications to date. In conclusion, Dr. Pradeep Mammen’s past clinical and academic accomplishments have demonstrated that he is a highly motivated and innovative academic cardiologist, who has acquired the skill set of leading a diverse group of individuals pursuing a common goal.

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