Chemical structure of chlorophyll.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6595",leadTitle:null,fullTitle:"Ballistics",title:"Ballistics",subtitle:null,reviewType:"peer-reviewed",abstract:"The edited volume Ballistics is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of engineered mechanics. The book comprises single chapters authored by various researchers and edited by an expert from the respective research area. Each chapter is complete in itself but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts by international authors on engineered mechanics and opens new possible research paths for further novel developments.",isbn:"978-1-83880-656-9",printIsbn:"978-1-83880-655-2",pdfIsbn:"978-1-83880-715-3",doi:"10.5772/intechopen.71462",price:119,priceEur:129,priceUsd:155,slug:"ballistics",numberOfPages:112,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"3e7fa96253ce890c092b37a8678e4d03",bookSignature:"Charles Osheku",publishedDate:"June 5th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6595.jpg",numberOfDownloads:7268,numberOfWosCitations:2,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:10,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 12th 2017",dateEndSecondStepPublish:"November 2nd 2017",dateEndThirdStepPublish:"January 5th 2018",dateEndFourthStepPublish:"March 22nd 2018",dateEndFifthStepPublish:"May 21st 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"148660",title:"Dr.",name:"Charles",middleName:"Attah",surname:"Osheku",slug:"charles-osheku",fullName:"Charles Osheku",profilePictureURL:"https://mts.intechopen.com/storage/users/148660/images/6109_n.png",biography:"Dr. Charles Attah Osheku was the Director of the Centre for Space Transport and Propulsion, Epe, Lagos, an activity Centre of the National Space Research and Development Agency (NASRDA), Nigeria. He obtained BSc in Mechanical Engineering from the Obafemi Awolowo University; MSc and PhD in Mechanical Engineering (Engineering Mechanics) from the University of Lagos, Nigeria. He was the incumbent Chairman of the Lagos Branch of Nigeria Society of Engineers\\\\\\' (NSE) Space Engineering Division and a Board Member of the Division. Dr Osheku was a Research Expert in Rockets and Missiles Solid Fuel Physics, Solid Rocket Engines Design, Structural, Flow and Combustion-induced Vibrations, Aircraft and Jet Noise Modelling and Dissipation and Vibration of Laminated Structures. Dr Osheku has 63 scientific papers to his credit, published in reputable International Journals, ASME International Offshore Mechanics Conferences. He is a COREN (Nigeria) - registered Engineer and a professional member of ASME and AIAA.\r\n\r\nNote from the publisher:\r\n\r\nIt is with great sadness and regret that we inform the contributing authors and future readers of this book that the Editor, Dr. Charles Attah Osheku passed away during the publishing process of the book and before having a chance to see its publication. Dr. Osheku was IntechOpen\\'s long term collaborator and edited his first book with us in 2018 (\\'\\'Lamination\\'\\'). The book \\'\\'Ballistics\\'\\' was his secont edited volume and contains his third published chapter with us. The fruitful collaboration continued until his final days. We would like to acknowledge Dr. Osheku\\'s contribution to scientific publishing, which he made during years of dedicated work and express our gratitude for his pleasant cooperation with us.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"813",title:"Engineering Mechanics",slug:"mechanical-engineering-engineering-mechanics"}],chapters:[{id:"59098",title:"Adaptive Navigation, Guidance and Control Techniques Applied to Ballistic Projectiles and Rockets",doi:"10.5772/intechopen.73511",slug:"adaptive-navigation-guidance-and-control-techniques-applied-to-ballistic-projectiles-and-rockets",totalDownloads:1250,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Accuracy and precision are the cornerstone for ballistic projectiles from the earliest days of this discipline. In the beginnings, impact point precision in artillery devices deteriorated when range were extended, particularly for non-propelled artillery rockets and shells. Later, inertial navigation and guidance systems are introduced and precision was unlinked from range increases. In the last 30 years, hybridization between inertial systems and GNSS devices has improved precision enormously. Unfortunately, during the last stages of flight, inertial and GNSS methods (hybridized or not) feature big errors on attitude and position determination. Low cost devices, which are precise on terminal guidance and do not feature accumulative error, such as quadrant photo-detector, seem to be appropriate to be included on the guidance systems. Hybrid algorithms, which combine GNSSs, IMUs and photodetectors, and a novel technic of attitude determination, which avoids the use of gyroscopes, are presented in this chapter. Hybridized measurements are implemented on modified proportional navigation law and a rotatory force control method. A realistic non-linear flight dynamics model has been developed to perform simulations to prove the accuracy of the presented algorithms.",signatures:"Raúl de Celis and Luis Cadarso",downloadPdfUrl:"/chapter/pdf-download/59098",previewPdfUrl:"/chapter/pdf-preview/59098",authors:[{id:"210535",title:"Associate Prof.",name:"Luis",surname:"Cadarso",slug:"luis-cadarso",fullName:"Luis Cadarso"},{id:"210536",title:"Mr.",name:"Raúl",surname:"De Celis",slug:"raul-de-celis",fullName:"Raúl De Celis"}],corrections:null},{id:"64567",title:"State-Space Modeling of a Rocket for Optimal Control System Design",doi:"10.5772/intechopen.82292",slug:"state-space-modeling-of-a-rocket-for-optimal-control-system-design",totalDownloads:2048,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"This chapter is the first of two others that will follow (a three-chapter series). Here we present the derivation of the mathematical model for a rocket’s autopilots in state space. The basic equations defining the airframe dynamics of a typical six degrees of freedom (6DoFs) are nonlinear and coupled. Separation of these nonlinear coupled dynamics is presented in this chapter to isolate the lateral dynamics from the longitudinal dynamics. Also, the need to determine aerodynamic coefficients and their derivative components is brought to light here. This is the crux of the equation. Methods of obtaining such coefficients and their derivatives in a sequential form are also put forward. After the aerodynamic coefficients and their derivatives are obtained, the next step is to trim and linearize the decoupled nonlinear 6DoFs. In a novel way, we presented the linearization of the decoupled 6DoF equations in a generalized form. This should provide a lucid and easy way to implement trim and linearization in a computer program. The longitudinal model of a rocket presented in this chapter will serve as the main mathematical model in two other chapters that follow in this book.",signatures:"Aliyu Bhar Kisabo and Aliyu Funmilayo Adebimpe",downloadPdfUrl:"/chapter/pdf-download/64567",previewPdfUrl:"/chapter/pdf-preview/64567",authors:[{id:"200807",title:"M.Sc.",name:"Bhar",surname:"Aliyu",slug:"bhar-aliyu",fullName:"Bhar Aliyu"}],corrections:null},{id:"61821",title:"Discrete Element Modeling of a Projectile Impacting and Penetrating into Granular Systems",doi:"10.5772/intechopen.75550",slug:"discrete-element-modeling-of-a-projectile-impacting-and-penetrating-into-granular-systems",totalDownloads:1132,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"From theoretical standpoint, it is difficult to analytically build a general theory and physical principles that critically describe the mechanical behaviour of granular systems. There are many substantial gaps in understanding the mechanical principles that govern these particulate systems. In this chapter, based on a two-dimensional soft particle discrete element method (DEM), a numerical approach is developed to investigate the vertical penetration of a non-rotating and rotating projectile into a granular system. The model outcomes reveal that there is a linear proportion between the projectile’s impact velocity and its penetration downward displacement. Moreover, depending on the rotation direction, there is a significant deviation of the x-coordinate of the final stopping point of a rotating projectile from that of its original impact point. For negative angular velocities, a deviation to the right occurs while a left deviation has been recorded for positive angular velocities.",signatures:"Waseem Ghazi Alshanti",downloadPdfUrl:"/chapter/pdf-download/61821",previewPdfUrl:"/chapter/pdf-preview/61821",authors:[{id:"227098",title:"Dr.",name:"Waseem",surname:"Alshanti",slug:"waseem-alshanti",fullName:"Waseem Alshanti"}],corrections:null},{id:"66819",title:"Analytical Prediction for Grain Burn Time and Burning Area Kinematics in a Solid Rocket Combustion Chamber",doi:"10.5772/intechopen.82822",slug:"analytical-prediction-for-grain-burn-time-and-burning-area-kinematics-in-a-solid-rocket-combustion-c",totalDownloads:1197,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter proposes the application of Newtonian particle mechanics for the derivation of predictive equations for burn time, burning and unburnt area propagation for the case of a core propellant grain. The grain is considered to be inhibited in a solid rocket combustion chamber subject to the assumption that the flame propagation speed is constant for the particular solid fuel formulation and formation chemistry in any direction. Here, intricacies surrounding reaction chemistry and kinetic mechanisms are not of interest at the moment. Meanwhile, the physics derives from the assumption of a regressive solid fuel pyrolysis in a cylindrical combustion chamber subject to any theoretical or empirical burn rate characterization law. Essential parametric variables are expressed in terms of the propellant geometrical configuration at any instantaneous time. Profiles from simulation studies revealed the effect of modulating variables on the burning propagation arising from the kinematics and ordinary differential equations models. In the meantime, this mathematical exercise explored the tendency for a tie between essential kernels and matching polynomial approximations. In the limiting cases, closed form expressions are couched in terms of the propellant grain geometrical parameters. Notably, for the fuel burn time, a good agreement is observed for the theoretical and experimental results.",signatures:"Charles A. Osheku, Oluleke O. Babayomi and Oluwaseyi T. Olawole",downloadPdfUrl:"/chapter/pdf-download/66819",previewPdfUrl:"/chapter/pdf-preview/66819",authors:[{id:"148660",title:"Dr.",name:"Charles",surname:"Osheku",slug:"charles-osheku",fullName:"Charles Osheku"},{id:"287885",title:"Dr.",name:"Oluleke",surname:"Babayomi",slug:"oluleke-babayomi",fullName:"Oluleke Babayomi"}],corrections:null},{id:"62018",title:"Ballistic Testing of Armor Panels Based on Aramid",doi:"10.5772/intechopen.78315",slug:"ballistic-testing-of-armor-panels-based-on-aramid",totalDownloads:1641,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Industry and market of ballistic protection materials and systems are characterized by a dynamic and competing succession of inventions for projectiles and protective systems. The requirements for the ballistic panels are many and complex, varying depending on the threat type, the required mobility in the tactical theater, and protection level. The safety degree, the price, and the dynamics of research in the field are also taken into account. This chapter underlines the necessity of testing ballistic protection panels made of LFT SB1 plus (multidirectional fiber fabrics, supplied by Teijin) against a certain threat in order to assess their resistance to this specific threat and the investigation of failure mechanisms in order to improve their behavior at ballistic impact. The models for ballistic impact are useful when they are particularly formulated for resembling the actual system projectile, target, and can be validated through laboratory experiments. Tests made on panels made of LFT SB1plus, according to NIJ Standard-0101.06-2008 gave good results for the panels made of 12 layers of this fabric, and the backface signature (BFS) was measured. The BFS upper tolerance limit of 24,441 mm recommends this system for protection level IIA, according to the abovementioned standard.",signatures:"Catalin Pirvu and Lorena Deleanu",downloadPdfUrl:"/chapter/pdf-download/62018",previewPdfUrl:"/chapter/pdf-preview/62018",authors:[{id:"229928",title:"Dr.",name:"Catalin",surname:"Pirvu",slug:"catalin-pirvu",fullName:"Catalin Pirvu"},{id:"230862",title:"Prof.",name:"Lorena",surname:"Deleanu",slug:"lorena-deleanu",fullName:"Lorena Deleanu"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5759",title:"Lamination",subtitle:"Theory and Application",isOpenForSubmission:!1,hash:"9a4f81291f9d75ed83b1f4f5e0b56f36",slug:"lamination-theory-and-application",bookSignature:"Charles A. 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\r\n\tAccording to WHO, 2.3 billion people worldwide, suffer from permanent teeth caries. The prevalence of primary teeth is estimated at 530 million. Untreated dental caries is being considered the actual most common health condition. Dental caries affects people throughout their lifetime, being a major factor for oral pain, aesthetic impairment, edentulism. Untreated dental caries results in affecting adjoining oral tissues, and, finally, may lead to systemic complications.
\r\n\tPrevention represents a key factor in managing this condition and includes public health measures, addressing the risk factors, as well as access to oral health services. A regular dental examination is crucial for detecting early signs of caries, and timely treatment. Materials choice and proper handling, if restorative treatment is needed, are of utmost importance, to prevent a recurrence. State-of-the-art new types of restorative materials, such as antimicrobial composites, stimuli-responsive composites, or self-healing composites, together with the use of nanotechnology, represent some future choices for restorative biomaterials.
Algae represent a highly diverse consortium of polyphyletic, thallophytic, photosynthetic, and cryptogamic organisms.
The microalga
Schematic of a prokaryotic cell with an indication of some of the methods used to probe cellular activity or growth [
Algae have six types of life cycles viz. haplontic, diplontic, isomorphic, heteromorphic, haplobiontic, and diplobiontic cycles; the exposition of these algal life cycles is discussed elsewhere [5]. The microscopic algae are the microphytes or microalgae and are typically found in freshwater and marine ecosystems at the benthic depths and in the water column. They are reported to be the chief converters of water and carbon dioxide to biomass and oxygen (see Eq. (1)) as they receive radiation from sunlight, and are therefore referred to as primary producers. Microalgae exist either individually, or in chains or groups; and depending on the species, their sizes are typically 3–30 μm, while the cyanobacteria are as small as 0.2–2 μm [2].
Aside from producing oxygen and availing themselves as food for a large number of aquatic animals, algae are a good resource base for fine chemicals, crude oil, food supplement for humans, and some pharmaceutical products and finished goods [5].
Pigments are chemical compounds that reflect and transmit only certain wavelengths of visible light. This makes them appear as the colors perceived. More important than their reflection of light is the ability of pigments to absorb light of certain wavelengths. A photosynthetic pigment (accessory pigment; chloroplast pigment; antenna pigment) is a pigment that is present in chloroplasts of algae and other photosynthetic organisms and captures the light energy necessary for photosynthesis. The reaction of each pigment is associated with only a narrow range of the spectrum, and it is necessary to produce several kinds of pigments with different colors to capture more of the sun’s energy. Five important pigments found in algae are (i) chlorophyll (ii) xanthophyll (iii) fucoxanthin (iv) phycocyanin and (v) phycoerythrin [6].
Algae and plants have chloroplasts in which the light-capturing chlorophyll is located, while in cyanobacteria the main light-capturing complex protein molecular assemblies are the phycobilisomes, which are located on the surface of thylakoid membranes [7]. Both chlorophyll and phycobilisomes absorb light most strongly between the high-frequency, high-energy wavelengths of 450 and 495 nm, which happen to be the blue region of the electromagnetic spectrum. Also, the photosynthetic pigments absorb the low-frequency, low-energy wavelengths between 620 and 750 nm, which is the red region of the electromagnetic spectrum. The chlorophyll pigment comes in different forms, and the structure of each type of Chlorophyll pigment is anchored on a chlorin ring with a magnesium ion at the centre. The side chain of each chlorophyll pigment type is different and they are so identified (see Figure 3 and Tables 1 and 2) [7, 8].
Chlorophyll - a porphyrin ring structure attached to a protein backbone. The porphyrin is built up of pyrrole molecules – 5 membered aromatic rings which are made of four carbons and one nitrogen atom. This ring system acts as a polydentate ligand and has a magnesium cation at its Centre [
Chlorophyll | ||||
---|---|---|---|---|
a | b | c1 | c2 | |
Molecular Formula | C55H72O5N4Mg | C55H70O6N4Mg | C35H30O5N4Mg | C35H28O5N4Mg |
C2 group | -CH3 | -CH3 | -CH3 | -CH3 |
C3 group | -CH=CH2 | -CH=CH2 | -CH=CH2 | -CH=CH3 |
C7 group | -CH3 | -CHO | -CH3 | -CH3 |
C8 group | -CH2CH3 | -CH2CH3 | -CH2CH3 | -CH2CH3 |
C17 group | -CH2CH2COO-Phytyl | -CH2CH2COO-Phytyl | -CH=CHCOOH | -CH=CHCOOH |
C17-C18 bond | Single (chlorin) | Single (chlorin) | Double (porphyrin) | Double (porphyrin) |
Occurrence | Universal | Plants | Algae | Algae |
Chemical structure of chlorophyll.
Chlorophyll | ||
---|---|---|
d | f | |
Molecular formula | C54H70O6N4Mg | C55H70O6N4Mg |
C2 group | -CH3 | -CHO |
C3 group | -CHO | -CH=CH2 |
C7 group | -CH3 | -CH3 |
C8 group | -CH2CH3 | -CH2CH3 |
C17 group | −CH2CH2COO − Phytyl | −CH2CH2COO − Phytyl |
C17-C18 bond | Single (Chlorin) | Single (chlorin) |
Occurrence | Cyanobacteria | Cyanobacteria |
Chlorophyll structural formulae.
Chlorophyll a with the molecular formula C55H72O5N4Mg is the most common type of Chlorophyll. It is a green pigment with a chlorin ring having magnesium at the centre (see Figure 3). Chlorin is a tetrapyrrole pigment, which is partially hydrogenated porphyrin. The ring-shaped molecule is stable with electrons freely migrating around it to establish resonance structures [9]. It also has side chains and a hydrocarbon trail and contains only –CH3 groups as side chains. The long hydrophobic tail anchors the molecule to other hydrophobic proteins on the surface of the thylakoid membrane. The chemical structural layout of chlorophyll shows a porphyrin ring attached to a protein backbone (see Figure 3). By substituting functional groups at positions C2, C3, C7, C8, and the C17-C18 bond, one can identify the structure of the desired chlorophyll (see Tables 1 and 2). Chlorophyll captures and absorbs blue, violet, and red light from the spectrum to transmit or reflect green, which is the color that the green algae exhibit [9, 10]. Oxygenic photosynthesis uses chlorophyll a to furnish electrons in the electron-transport chain. Photosystems I and II harbor many pigments that help to capture light energy. A unique pair of pigment molecules are located at the reaction site of each photosystem. For photosystem I the unique pair is referred to as P700, while for photosystem II it is identified as P680. These reaction sites receive resonance energy released from chlorophyll a to sustain the redox reactions [10].
Chlorophyll b is found only in the green algae and in plants, and it absorbs most effectively at 470 nm (blue) but also at 430 nm and 640 nm. Molecular formula - C55H70O6N4Mg. It is an accessory photosynthetic pigment. The molecular structure consists of a chlorin ring with Mg centre. It also has side chains and a phytol tail. Pyrrole ring II contains an aldehyde group (− CHO). Chlorophyll b absorbs energy that chlorophyll a does not absorb. It has a light-harvesting antenna in Photosystem I [11].
Xanthophyll is one of the two major groups of the carotenoids group. Generally, it is a C40 terpenoid compound formed by condensation of isoprene units. Xanthophyll, with the formula C40H56O2, contains oxygen atoms in the form of hydroxyl groups or as epoxides. Xanthophyll acts as an accessory light-harvesting pigment. They have a critical structural and functional role in the photosynthesis of algae and plants. They also serve to absorb and dissipate excess light energy or work as antioxidants. Xanthophyll may be involved in inhibiting lipid peroxidation [12].
Fucoxanthin, with the formula C42H58O6, is a xanthophyll carotenoid, being an accessory pigment that drives limited photosynthetic reactions in brown algae (phaeophytes) and other stramenopiles. It renders the brown or olive-green color to these seaweeds. Fucoxanthin captures the red light of the spectrum for photosynthetic activities. Some edible brown algae produce this pigment in abundance, and typical candidates in this category include
Phycocyanin is a protein-pigment complex found in cyanobacteria as an accessory pigment to phycobilisomes. As a phycobiliprotein, phycocyanin is identified by the color it bears as blue phycocyanin. Depending on the cyanobacterial species, this can be phycocyanin, showing maximum absorbance at 620 nm and identified as C-PC, and allophycocyanin with maximum absorbance at 650 nm and identified as A-PC. From the red microalgae, phycocyanin is identified as R-PC [13]. The molecular structure of phycocyanin changes with the pH of the medium, exhibiting the (αβ)3 trimeric structure at pH 7. However, at the pH range of 5–6, the much more available phycocyanin, C-PC, assumes the hexameric structural conformation (αβ)6. Phycocyanin boosts the human and animal immune systems and protects against certain diseases. It exhibits hepatoprotection, cytoprotection, and neuroprotection. Persons undergoing chemotherapy and radiation for cancer are placed on Phycocyanin from spirulina as a dietary supplement to ease negative symptoms during treatment as well as rejuvenate post-treatment. Phycocyanin is used in the food industry as a food additive [12, 14].
Phycoerythrin is an accessory pigment to the main chlorophyll pigment complex found in red algae and cryptophytes; it is part of a covalently bonded phycobilin chromophore in the family of phycobilins, typical of which is phycoerythrobilin, the phycoerythrin acceptor chromophore. Phycoerythrin is made up of (αβ) monomers aggregates. Except for phycoerythrin 545 (PE545), these monomer aggregates are assembled into (αβ)3 trimers or (αβ)6 hexamers with 3 or 32 symmetry and enclosing central channel [13, 14]. In red algae, they are attached to the stroma of thylakoid membranes of chloroplasts, whereas in cryptophytes, phycobilisomes are reduced and housed inside the lumen of thylakoids. Phycoerythrin captures light energy from the electromagnetic radiation and directs it to the reaction site through the phycobiliproteins, phycocyanin, and through A-PC. Each trimer and hexamer in the phycobilisome (PBS) has a minimum of one linker protein at the central channel. The α and β chains in B-phycoerythrin (B-PE) and R-phycoerythrin (R-PE) from the red algae also have γ sub-units conferring both link and light-capturing capabilities due to the presence of chromophores [14] (Figure 4).
The structure of the pigments: (a) xanthophyll (b) Fucoxanthin (c) Phycocyanin and (d) Phycoerythrin [
The chloroplast of algal cell contains the water-soluble phycobilin pigments and while the same phycobilin pigments are found in the phycocyanin and phycoerythrin of Cyanobacteria and the red algae, the Rhodophyta. The algal chlorophyll has a structural difference from Bacteriochlorophylls (Bchl) of cyanobacteria, the latter having one of the porphyrin rings saturated, and absorbing longer wavelengths of light as opposed to chlorophylls.
The colors of pigments are the reflections of the electromagnetic spectrum from the pigments. A portion of the pigment molecule causes the formation of the color perceived, and this moiety is referred to as
In general, chromophores comprise four pyrrole rings; identified as (i) open-chain pyrroles with no transition metal involved – typically, carotenoids, phycobilins, and phytochromes, (ii) pyrroles arranged as a porphyrin ring with a central transition metal atom – typically, chlorophylls and bacteriochlorophylls (C55H74MgN4O6). Chlorophyll absorbs all other visible components of light except green, which is the color the human eye sees of plants in their leaves. Various chlorophylls and accessory pigments (as discussed in sections 2.1–2.5) have characteristic
Relative absorbance of photosynthetic pigments as a function of the wavelength of light [
The Calvin cycle [
The dark reactions of photosynthesis occur in the stroma of the chloroplast and are referred to as the Calvin cycle. Although the Calvin cycle does not utilize light and can happen during the daytime or at night, they employ products of the light-dependent reactions to propagate. Products of the light-dependent reaction are ATP and reduced NADP; the energized electrons from the light-dependent reactions provide the energy to produce carbohydrates from carbon dioxide molecules.
The first reaction in the Calvin cycle: Carbon fixation.
The Calvin Cycle first produces phosphoglyceric acid (PGA), which is phosphorylated, using the energy carriers ATP and NADPH generated by the photosystems I and II, to produce 12 molecules of phosphoglyceraldehyde (PGAL). Two molecules of PGAL are ejected from the cycle in the form of a glucose molecule. The other ten molecules of PGAL are converted to 6 RuBP molecules, using the inherent energy in ATP and the cycle continues [19, 20].
The summary of the reactions in the Calvin cycle (see Eq. (2))
Light has properties of both waves and particles, from the quantum mechanics point of view [20]. The particulate behavior of light presents light as a stream of particles of energy, known as photons, which interact with electrons to cause the energy contained in the light to disappear and then reappear as the kinetic energy of the ejected electrons plus a work function.
where
By definition,
where
Thus for sunlight with a wavelength of 650 nm (650 × 10−9 m), the energy is computed in Eq. (6).
If all this were to be used for synthesizing ATP from ADP and
Chlorophylls b, c, d, and e are accessory pigments with xanthophylls, and carotenoids in algae and protistans, Pigments that are not accessory to chlorophyll absorb light energy at wavelengths that do not stimulate chlorophyll. Light energy absorbed by accessory pigments is channeled to the reaction site and is converted into chemical energy. The ability to absorb some energy from the longer, more penetrating wavelengths probably conferred an advantage to the benthic photosynthetic algae. Depending upon turbidity of the water, the shorter, high energy wavelengths penetrate very little in the euphotic zone (below 5 meters) in seawater [7, 8]. Chlorophyll molecules being the main producers of pigments are bound to proteins of the photosynthetic membranes and capture the sunlight in oxygenic plants, and convert light energy into chemical energy. This is facilitated by pigment-protein complexes known as Photosystem I (PSI) and Photosystem II (PSII) reaction sites [9]. In PS II water is
Photo-isomerization of all-trans to 13-cis retinal in bR [
The most common chlorophylls are chlorophyll a, chlorophyll b, and chlorophyll c1, and chlorophyll c2. Each pigment registers a maximum signal at a particular wavelength of maximum absorption (
Photosynthesis – Irradiance curve.
The saturation irradiance (
Microalgae is a promising renewable resource for biofuels, and optimization and control of the biomass growth production have gained economic and commercial interests. Algae do not compete with traditional food crops for space and resources [5]. Microalgae are highly diverse and differences within and between both species and populations lead to significant differences in biogeography and the environment. The macromolecular composition of the microalgae is of interest for understanding nutrient competition within microalgal communities, food web interactions, and developing algal systems for the development of biofuels, nutraceuticals, and mariculture [3]. Production of microalgae-derived metabolites requires processes for culturing the algae, recovery of the biomass, and further downstream processing to purify the metabolite. The cost of producing microalgal bioactive agents has to be weighed as the downstream recovery of the microalgal products can be substantially more expensive than the culturing of the microalgae [5]. Depending on their origin, algae are referred to as terrestrial algae, snow algae, seaweeds, and phytoplankton. Ubiquitous in marine, freshwater, and terrestrial habitats and possessing broad biochemical diversity, which is the basis for many biotechnological and industrial applications [3].
Hatcheries are used to produce a range of microalgae biomass, which are used in a variety of ways for commercial purposes. Studies have adduced the success of a microalgae hatchery system to the following factors: (i) the dimensions of the container/bioreactor where microalgae are cultured, (ii) exposure to illumination, and (iii) concentration of microalgal cells within the reactor [23, 24]. Photosynthesis is one of the basic biochemical transformations of photosynthetic micro-organisms that convert solar energy into chemical energy. Many microalgae are autotrophs, which use photosynthesis to produce food. Some heterotrophic microalgae can grow in the dark by utilizing organic carbon. Some microalgae grow by combining both autotrophy and heterotrophy into a hybrid cultivation mode called mixotrophy [4, 6]. Diatoms and dinoflagellates are the two types of microalgae. Diatoms can be spheres, triangles, elliptical or stars. Many dinoflagellates have two flagella for their movement through the water. Both diatoms and dinoflagellates contain oils in their cells, helping them to swim. Both diatoms and dinoflagellates can grow very quickly and cause algal blooms [3].
There are two main advantages of culturing microalgae using the open pond system. Firstly, an open pond system is easier to build and operate. Secondly, open ponds are cheaper than closed bioreactors because closed bioreactors require parts that are expensive to acquire. However, where the temperature is the growth or lipid accumulation limiting factor, using open pond systems may decrease the productivity of certain commercially important strains such as
Algae raceway pond: The microalgae culture broth is constantly kept in motion with a powered paddle wheel [
Many photobioreactors have been suggested for commercial production of algal biomass. However, only a few of them are suitable for practical application because of poor gas mass transfer. The vertical tubular photobioreactor provides a greater surface area for the interaction of light and the algal cells, increasing the time of gas mass transfer in the culture broth, and the efficient uptake of nutrients. Most times, commercial cultivation of microalgae in vertical reactor systems and reactors of other configurations is not economically viable in batch mode, due to the time taken to load, unload, and clean the reactor systems. The vertical tubular reactor can be made of alveolar panels, polyethylene sleeves, or glass tubes and supported on steel frames (see Figure 11). The low productivity characterizing this reactor system is overcome when the surface area to volume ratio is increased. The O2 gas mass transfer is aided by bubbling air through the culture broth [23].
Vertical tubular photobioreactors for culturing microalgae [
This is an outdoor microalgal cultivation system, which has tubes laid on the ground to form a network of loops (see Figure 12(b)). A pump is used to mix the microalgal suspended culture, which raises the culture vertically periodically into a photobioreactor. Pulsed mixing at intervals produces better results than continuous mixing.
Horizontal tubular photobioreactor of different orientations [
This is an outdoor microalgal cultivation technique for the production of biomass and metabolites under a highly controlled environment. By this technique, the air is moved within the system to circulate the medium in which microalgae is growing. The culture is grown in transparent tubes that lie horizontally on the ground and are connected by a network of pipes (see Figure 13). Air is passed through the tube such that air escapes from the end that rests inside the reactor that contains the culture and creates an effect like stirring [28]. Other configurations of the airlift reactor are an improvement over this design. The external-loop ALR is a promising configuration for breakthrough scale-up
Different types of airlift photobioreactor [
Different microalgae strains acclimate in different environments, evolving their metabolic pathways to stimulate and propagate growth. However, the extent of growth depends on the composition of the culture media which can be enhanced by either inorganic or organic carbon metabolism or both. Other co-factors such as nutrient availability, pH, chemical oxygen demand (COD), and temperature also influence growth, and the accumulation of metabolites in microalgae (see Table 3) [29].
Metabolic mode | Energy source | Carbon source | Light availability | Metabolism availability |
---|---|---|---|---|
Photo-autotrophic | Light | Inorganic | Obligatory | Fixed |
Heterotrophic | Organic | Organic | Not required | Switch between sources |
Photoheterotrophic | Light | Organic | Obligatory | Switch between sources |
Mixotrophic | Light & organic | Inorganic & organic | Not obligatory | Simultaneous utilization |
Microalgal metabolic requirements.
The photosynthetic CO2-fixation in microalgae suffices to possess a greater ability to fix CO2. Photo trophy refers to an autotrophic mode of metabolism in which organisms can harness light energy with the help of photosynthetic pigments and convert it to chemical bond energy in the form of ATP (photophosphorylation).
Autotrophy is the ability of PMOs to use inorganic carbon in the form of CO2 as the sole source of carbon to synthesize organic compounds necessary to build cell components. This is also referred to as carbon-autotrophy to distinguish the ability of some organisms to use molecular nitrogen as the sole source of nitrogen. Such organisms are referred to as nitrogen autotrophs. However, autotrophy as used in this chapter is carbon autotrophy. This is a property that is present primarily, in plants, algae, and phototrophic bacteria including cyanobacteria [30].
Aside from these organisms, all of which are photosynthetic, several groups of non-photosynthetic bacteria can grow using CO2 as the sole source of carbon by their ability to oxidize inorganic compounds. Such organisms are chemoautotrophic or chemolithotrophic [31].
CO2 is the end-product of aerobic respiration, a process that releases the energy of respiratory substrates. Carbon dioxide is, therefore, poor in energy content. In autotrophic metabolism, this energy-poor compound is used to build organic molecules which are much richer in energy content. Therefore, It is noted that the conversion of CO2 to organic compounds requires the input of energy from an external source. The ultimate source in the case of photosynthesis is radiant energy and in the case of chemolithotrophy is the oxidation energy of inorganic chemical compounds. In either case, the immediate source of energy for driving the endergonic reaction involved in the conversion of CO2 to organic compounds is ATP [32].
In photosynthesis, ATP is generated with the help of photosynthetic pigments through a process known as photophosphorylation. In chemoautotrophy, the energy of oxidation of inorganic compounds is channelized into the respiratory chain for ATP synthesis by oxidative phosphorylation.
Thus, autotrophic metabolism consists of two sets of reactions viz. (1) the ATP and the reducing force are generated and, (2) they are used for the reduction of CO2 to organic compounds.
The reactions in (1) are different in phototrophic and non-phototrophic autotrophs. But the reactions in (2) are common between the two groups. In the majority of autotrophs, the reactions involved in the reduction of CO2 proceed via a cyclic pathway, known as the reductive pentose phosphate pathway or, more commonly, as the Calvin-Benson cycle, or simply the Calvin cycle, although other pathways are also known to operate in some organisms, both in the phototrophic green plants and bacteria. The reduction of CO2 to yield organic compounds is commonly known as CO2-fixation [32, 33].
The supply of sufficient light for massive growth is the main goal and a limiting factor for microalgal cultivation. To ignore the requirement for illumination and present the possibility of high cell concentration, points at heterotrophic cultivation as a promising, efficient, and sustainable strategy for certain microalgae to produce metabolites of value by using carbon substances as the sole carbon and energy source. The optimized preliminary cell culturing of microalgae species is an important stage in culturing microalgae biomass at the commercial scale. The growth environment during the culturing process can be [32] either autotrophic (inorganic carbon) or heterotrophic (organic carbon) depending upon the nature of cells and their growth tendencies. Heterotrophic and mixotrophic microalgae are more capable of growing much faster with higher cellular oil accumulation as compared to autotrophic microalgae species. However, heterotrophic microalgae require organic carbon sources like glycerol, glucose, or acetate as a sole source of carbon for growth, which is responsible for about 80% of the costs of culture media [33]. The metabolism of respiration is applied to produce energy. The respiration rates, intimately geared to the growth and division, are determined by the oxidization of organic substrates of the given microalgae [32]. Glucose provides the organic carbon needed and it is preferred because of its high energy density compared to other sources. The oxidative assimilation of glucose employs either the Embden–Meyerhof–Parnas (EMP) pathway or the pentose phosphate (PP) pathway depending on the cycle position. During the dark cycle, PMOs assimilate and metabolize glucose via the PP pathway. However, during the daytime cycle, glycolysis in the cytosol is via the EMP pathway [34]. The growth rate, lipid content, and the ATP of microalgae under the heterotrophic metabolic strategy are higher compared to those under the photoautotrophic metabolic strategy but depend mainly on the PMO’s species and strain used. The PMO’s growth is steady and rapid in a nutrient-rich culture media using a high level of system control, to achieve biomass production of 50–100 g L−1 in heterotrophy which is higher than that achieved in photoautotrophy [35].
Heterotrophic metabolism eliminates the two main problems associated with autotrophic metabolism viz. (i) it allows the use of practically any vessel as a bioreactor, and (ii) low energy and high yield, as major outcomes, giving a significant reduction in costs for the process. Cost-effectiveness and relative simplicity of operations and daily maintenance are the main attractions of the heterotrophic growth approach. A significant benefit is that it is possible to obtain, heterotrophically, high densities of microalgae cells that provides an economically feasible method for large scale, mass production cultivation [34].
Heterotrophy has its drawbacks viz. (1) The microalgae species and strains that can grow by the heterotrophic strategy are limited; (2) Increasing energy expenses and costs by adding organic carbon substrate; (3) Contamination and competition with local microorganisms; (4) Inhibition of growth by excess organic substrate; and (5) Inability to produce light-induced metabolites [35]. Nonetheless, heterotrophic cultures are gaining increasing application for producing a wide variety of microalgal metabolites from bench experiments to commercial scale.
Mixotrophic cultivation of microalgae strategies provides both carbon dioxide and organic carbon simultaneously and both chemoheterotrophic and photoautotrophic metabolisms operate concurrently. Microalgae biomass produced by this approach has high density and contains high-value lipids, proteins, carbohydrates, and pigments; and the product range is very versatile [7, 8, 9, 10]. These products range from high-value nutraceuticals, food supplements, and cosmetics to the lower value commodities biofuels, food, fertilizer, and application in wastewater treatment [10, 11, 12].
Microalgal biomass contains considerable amounts of bioactive molecules such as carotenoids (astaxanthins, β-carotenes, and xanthophylls), omega-3 fatty acids, polysaccharides, and proteins, which can be used in several applications as colorants, pharmaceuticals, food, food additives, and feed and as bioplastics.
Microalgae produce carotenoids and all known xanthophylls found in terrestrial plants (e.g., zeaxanthin, lutein, antheraxanthin). Astaxanthin is a carotenoid pigment that occurs in microalgae, trout, yeast, and shrimp, among other sea creatures. It is found in abundance in Pacific salmon and the fish appears pinkish due to the presence of astaxanthin. Astaxanthin is an antioxidant; it is said to have many health benefits. Carotenoids as accessory pigments, capture light energy during photosynthesis and promote photoprotection. Stains of
Lutein, a xanthophyll, is one of the many known naturally occurring carotenoids. Lutein is synthesized only by plants and is found in large quantities in green leafy vegetables like kale, spinach, yellow carrots, and in dietary supplements. The lutein-rich microalgae
Microalgae are the dominant sources of polyunsaturated fatty acids in the marine food chain.
The acetyl-CoA condensation to fatty acyls is one of the methods by which biohydrocarbons are produced in-situ biotic organisms. The second biohydrocarbon production pathway is the isopentenyl pyrophosphate (IPP) condensation to higher isoprenoids, which is responsible for the diverse isoprene derivatives, many of which are suitable for fuels or fuel additives due to their desirable cetane and pour point and other fuel properties [5]. The low-to-zero-oxygen content of isoprenoids results in energy densities similar to the alkanes in current diesel fuels and diversity of ring structures affords lower cloud points [46, 47]. Additionally, it has been found that slight modifications to enzymes involved in the final steps of higher isoprenoid synthesis can result in subtle product variants with distinct thermochemical and thermophysical properties [47]. The precursors for the majority of these compounds are metabolic intermediates in photosynthetic microorganisms (PMOs). Genetic engineering of microalgae and cyanobacteria would be required to enhance the productivity of PMOs [5].
Triglycerides are lipids or waxes, formed by biochemically combining glycerol and fatty acids in the ratio of 1: 3 respectively. This combination may be a simple type or a mixed type. Triglycerides in which the glycerol backbone is attached to three molecules of the same fatty acid are referred to as simple triglycerides. Typical in this category is tripalmitin, C3H5(OCOC15H31)3. Only a few of the glycerides occurring in nature are of the simple type; most are mixed triglycerides (see Figure 14) [48]. Based on saturation and unsaturation of the attached fatty acids, triglycerides can be classified as saturated, monounsaturated, and polyunsaturated. In saturated triglycerides, all the fatty acids are saturated. Saturated fats abound in many animal products such as butter, cheese, cream, and fatty meats, ice cream, and whole milk. In monounsaturated triglycerides most of the fatty acids are monounsaturated. Vegetable oils such as canola oil, olive oil, peanut oil, and sesame oil have high levels of monounsaturated fats and polyunsaturated triglycerides. Omega-3 and omega-6 fatty acids are polyunsaturated.
The structure of triglyceride showing the simple and mixed types.
Microalgae are a promising renewable resource for green production of triacylglycerols (TAGs), which can be used as a biofuel feedstock. Nitrogen starvation is the most effective strategy to induce TAG biosynthesis in microalgae [48]. One of the best microalgae for lipid production is
Phospholipids are made up of four components viz. fatty acids, a platform to which the fatty acids are attached, phosphate, and an alcohol attached to the phosphate. Phospholipids may be built on either glycerol or sphingosine framework. Phospholipids built on glycerol framework are called phosphoglycerides (or glycerophospholipids). A phosphoglyceride consists of a glycerol molecule, two fatty acids, a phosphate, and choline, which is an alcohol. Phosphoglycerides are the most abundant phospholipid molecules found in cell membranes. The phospholipids built on sphingosine framework are referred to as sphingolipids or glycolipids, depending on the number of glucose or galactose molecules they contain; and lipoproteins, which are complexes of cholesterol, triglycerides, and proteins that transport lipids in the aqueous environment of the bloodstream. These are complex lipids. The algae contain three major phospholipids, phosphatidylglycerol (PG), phosphatidylethanolamine (PE), and phosphatidylcholine (PC). Phospholipids are synthesized by both prokaryotic and eukaryotic organisms. They are the major component of most eukaryotic cell membranes, which play a fundamental role in compartmentalizing the biochemistry of life [52]. The hydroxyl groups at positions C-1 and C-2 in phosphoglycerides are esterified to the carboxyl groups of the two fatty acid chains. The hydroxyl group at position C-3 hydroxyl group of the glycerol backbone is esterified to phosphoric acid. At this extent of conversion, the product is phosphatidic acid, which is the simplest phosphoglyceride. Phosphatidic acid now serves as the backbone on which most phosphoglycerides are derived having moieties such as serine, ethanolamine, choline, glycerol, and the inositol. Consequently, we have phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, phosphatidylglycerol, and phosphatidylinositol respectively (see Figure 15) [52].
Sphingolipids and phospholipids: The classification of sphingolipids is based on the group attached to the sphingosine (LCB) backbone (a). Sphingomyelin (b) and ceramides (c-e) differ in fatty acid length, unsaturation, and in the type of attached head group and hydroxylation. Phospholipids with glycerol framework: (f) phosphatidylethanolamine, (g) phosphatidylcholine [
Metabolites from both microalgae and cyanobacteria have attended to both human and animal health and food needs and these microorganisms have become attractive resources for bioactive natural products that have wide applications in pharmaceutical, food, and chemical industries. Algae-derived bioactive substrates are employed for drug screening, given their tremendous structural diversity and biological availability. Microalgae biomass has a wide range of physiological and biochemical characteristics and contains 50–70% protein compared to 50% in meat, and 15–17% in wheat, with 30% lipids, more than 40% glycerol, 8–14% carotene, and a reasonably high levels of vitamins B1, B2, B3, B6, B12, E, K, D, and others [54, 55, 56].
Microalgae that have been cultivated on commercial scales and are available include
Abiotic, Biotic, and process-related factors influence the growth of algae. Some of the abiotic factors are illumination and luminous intensity, daytime to night-time ratio, the temperature of the culture medium, nutrient availability, O2, and CO2 mass transfer, pH value, the hydraulic retention time (HRT), salinity, and presence of growth-inhibiting chemical agents [30]. Some of the biotic factors are the presence of pathogens (bacteria, fungi, viruses) and the presence of more than one algae strains. Each algae strain has a different capacity to assimilate nutrients, and in mixed cultures, there is competition for the available nutrients in the media, which may afferent the growth of some strains [36]. Process related factors that may influence algal growth are hydrodynamics of the culture broth, which is influenced by the choice of the bioreactor, the initial algal cell concentration in the reactor, and the related frequency of harvesting algal biomass [57, 58].
There is a major difference between microalgae and cyanobacteria in terms of their cell structure and this work has presented unmistakable evidence that microalgae have a nucleus and chloroplast, and their makeup includes their full identity in a two-stranded DNA. On the other hand, cyanobacteria are identified by one-stranded DNA and do not have a nucleus and neither a chloroplast. However, Microalgae and cyanobacteria do photosynthesize to produce their food.
It is seen from research as discussed in this chapter that value products aimed to meet pharmaceutical and food needs are obtainable by continuous availability of nutrients to the microalgae in the culture media. It is also seen that to accumulate lipid in the order of triglycerides for biodiesel production, microalgae must experience nutrients deficiency in the culture media at the stationary stage of growth.
The hydrodynamics of the microalgal culture broth depends on the choice of bioreactor for a particular cultivation activity and contributes to the algal growth factor.
The versatility of the microalgal biomass is expressed in the diversity of metabolites produced by manipulation of the growth factors in favor of the desired product. Also, the choice of the strain will drive towards the targeted product.
The authors appreciate the Institute for Water and Wastewater Technology (IWWT), Durban University of Technology, Durban for providing the platform for scientific investigations.
The authors have declared that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this chapter.
Expeditious expansion and industrial development near the rivers have led to more stress on the river, and with increased stress, the water becomes polluted, and worsening environmental health is observed [1]. The water-soil interface and the water-atmosphere interface are the medium through which the heavy metals travel [2, 3]. Both anthropogenic activities and geochemical processes are responsible for heavy metal contamination in ecosystems [4]. Elements that have high density and are less noxious are known as heavy metals. Examples of heavy metals are lead, iron, mercury, cadmium, zinc, arsenic, copper, and chromium and the actual volume of these heavy metals is more than 6 g/m3 [5]. Heavy metals have the property of environmental persistence and bioaccumulation, and these heavy metals enter the aquatic system through various routes. These heavy metals not only impair the quality of the aquatic ecosystem but also human health [6, 7]. These heavy metals can be found on the layer of earth in their regular form. These heavy metals are so dangerous that they cannot be degraded or decomposed and they have the arability to bioaccumulate [8]. These heavy metals once get into the ecosystem through the air, via drinkable water, or multiple chemicals and products that are manmade. The route of administration of these heavy metals is via inhalation, ingestion, and skin absorption. These heavy metals get into the biosphere via human activities, which include industrial production, mining, agriculture, and transportation [9]. Some methods are fossil fuel burning, smelting of different, waste from the municipality, fertilizers, pesticides, and sewage these all are considered to be the primary sources of metal pollution [10, 11, 12, 13]. The toxicity of these heavy metals in the human body reduces energy levels; disrupts brain functioning; disturbs the functioning of various other organs such as the brain, lungs, liver, and kidney; and also hinders blood composition. If the contact with heavy metals continues, then it can hinder the physical, neurological, and muscular functioning. And due to these diseases like multiple sclerosis, Parkinson’s disease and muscular dystrophy, and Alzheimer’s disease. Chronic exposure to some of the heavy metals and their compounds may even cause cancer [14]. Pollution of these heavy metals into the river may cause distressing effects on the ecological balance of the aquatic environment, and with the extent of contamination, the diversity of aquatic organisms becomes limited [15]. The fish in the aquatic ecosystem can be used for examining the well-being of biota. Due to pollutants in the food chain of organisms, harmful effects can be seen and the aquaculture can become dead [16]. These heavy metals are neurotoxins for the fish living in the aquatic environment. When these heavy metals enter the fish body, they interact with them to generate biochemical reaction inside the fish, which makes it difficult for fish to communicate with their surroundings [17]. The presence of these heavy metals leads to diseases like Minamata, which is organic mercury poisoning. When these heavy metals get bioaccumulated, they become a threat to both the human population and animals who uses that water [18]. Modeling of risk assessment is divided into four stages, i.e., exposure assessment, toxicity (dose-response) assessment, hazard identification, and risk characterization. There are three pathways through which humans get exposed to traced metals, which include directly ingesting, inhaling through the mouth or nose, and via skin absorption when it gets exposed. From the water, the heavy metals usually enter through ingestion and dermal absorption. To assess exposure, the average daily dose is measured for pollutants through different identified paths. In a dose-response assessment for no carcinogens, reference doses (RfD) are calculated, and for carcinogens, slope factors (SF) are obtained by the United States Environment Protection Agency (USEPA) Integrated Risk Information System (IRIS) database. With the help of the facts which are discussed above, there was a study done with an aim to evaluate the water quality of the Subarnarekha River relating to metals, their temporal classification, source of identification, and assessment of human health risk when that water was ingested or the contaminate when absorbed through the skin. Through this, it is possible to know the contamination level and accordingly, the strategies were planned (Table 1) [19, 20].
Heavy metal ions | WHO’s permissible limit (mg L−1) |
---|---|
Se | 0.02 |
Hg | 0.001 |
Mn | 0.02 |
Ag | 0.1 |
Cd | 0.05 |
Cr | 0.003 |
Pb | 0.01 |
Zn | 3.00 |
Fe | 0.30 |
Cu | 0.02 |
As | 0.01 |
Permissible limit of heavy metal ions in water [21].
The presence of these heavy metals on the surface of the water can be due to natural or anthropogenic activities. In natural activities, weathering of rocks that contain metals, an eruption from volcanos, fires in the forest, and naturally occurring processes of weathering can be included. From these activities, metal enters the different sections of the environment. Heavy metals can be found in the forms of sulfates, hydroxides, oxides, sulfides, phosphates, and silicates [12, 22]. A huge amount of accumulation of heavy metals into the water is mainly due to anthropogenic and natural activities. Some more examples of natural source through which heavy metals contaminates water are, wet and dry deposition of atmospheric salts, water-rock interaction, or water interaction with the soil. While the sudden increase in urbanization and industrialization are an example of anthropogenic sources through which water get contaminated (Table 2; Figure 1) [23].
Heavy metal ion | Common sources |
---|---|
Copper (Cu) | Fertilizers, tanning, and photovoltaic cells |
Zinc (Zn) | Soldering, cosmetics, and pigments |
Silver (Ag) | Refining of copper, gold, nickel, zinc, jewelry, and electroplating industries |
Chromium (Cr) | Leather industry, tanning, and chrome plating industries |
Arsenic (As) | Wooden electricity poles that are treated with arsenic-based preservatives, pesticides, fertilizers, the release of untreated effluents, oxidation of pyrite (FeS) and arsenopyrite (FeAsS) |
Mercury (Hg) | Combustion of coal, municipal solid waste incineration, and volcanic emissions |
Cadmium (Cd) | Paints, pigments, electroplated parts, batteries, plastics, synthetic rubber, photographic and engraving process, photoconductors, and photovoltaic cells |
Lead (Pb) | PVC pipes in sanitation, agriculture, recycled PVC lead paints, jewelry, lead batteries, lunch boxes, etc. |
Major sources of some heavy metal ions in water [24].
Contamination of water through different sources.
Trace metals are found in excess levels in the environment, they are formed by geographical processes such as volcanic eruptions, weathering of rocks, and leaching into rivers, lakes, and oceans due to the action of water [25]. The presence of heavy metals in water depends on the local geology, hydrogeology, and geochemical characteristics of the aquifer [26]. One of the main sources of pollution is weathering. The weathering of the sedimentary rocks such as limestone or dolomite or shale makes the water contaminated or polluted. When there is an interaction of water with rock element, it also leads addition of these elements into the water; thus, contamination occurs. Examples of such elements are granite, syenite, basalt, gabbro, nepheline, and andesite. Due to the particular ore or the minerals, the element level increases. Elements examples are magnetite, hematite, goethite, siderite, calcite, cuprite, malachite, azurite, chromite, kaolinite, montmorillonite, arsenic trioxide, orpiment, arsenopyrite, calamine, smithsonite, pyrolusite, and rhodochrosite [27, 28, 29, 30]. The sulfide deposition also increases as it is associated with the mineralization of the gold and hydrous iron oxide ores [31].
Anthropogenic events, in which human settlement replaced the natural forest and agricultural activities have increased the environmental impacts. Such activities have contaminated the aquatic ecosystems, which include spring waters from the river like the Amala and Nyangores, tributaries of Mara River, Indonesia in Mau Complex. The maximum of forest land is converted into human settlement and agriculture. People who live near the Mara River Basin use that spring water for the purpose of animal and agricultural purposes [21]. The water carrying capacity has decreased with the rapid increase in industrialization and urbanization. Hg concentration in water has increased with agriculture activities and human activities. Activities like domestic sewage into the water, solid waste burning, coal and oil combustions, and pyrometallurgical processes and mining are the main reason for this. Water, by either snow or rain, brings the contaminated soil with Hg into the adjacent water areas [32, 33]. The source of Ni is the corroded metal pipes and containers [34]. The major source of lead in water majorly comes from additives of paints and petrol and aerosol precipitation, which is formed due to the high temperature used in industrial processes for the purpose of coal combustion, smelting, and cement production [35], and chloralkali, batteries, fluorescent lamps, thermometers, and electronic switches production. Chemical industries are some industrial activities through which Hg pollutes the water system and these activities are the largest contributor to Hg contamination in the environment [36].
Huge amount of untreated sewage from domestic is thrown into the river. This untreated waste from domestic has the presence of toxins. These toxins are due to the presence of solid waste or from the litter of plastic, or the contamination of bacteria due to the presence of these the water can get polluted. Domestic untreated water is thrown directly into the water resource and this majorly causes pollution inside the water and harms the ecosystem [37]. These pollutants majorly depend upon what kind of industry has thrown those pollutants. When these toxic metals get inside the water, they decrease the quality of the water [38]. Around 25% of pollution inside the water is caused only by these industries [39]. When the water gets contaminated, the water gets enriched by the nitrogen and phosphorous elements. With the presence of these nutrients, the growth rate of algae gets multiplied, and then it competed with the surrounding aquatic biota for the dissolved oxygen in water [40]. The presence of nitrite and nitrate anions leads to a major threat to the exposed organisms; examples of such threats are methemoglobinemia. It is more common in small children, and the symptoms caused by this are cyanotic color in the skin due to blood alterations [41]. Water sources that get deposited by this sewage also become anions rich, due to the presence of chlorine in urine, and NaCl is used in the human diet. On the side of the sea, there is the presence of chloride in high concentrations due to the leakage of salt into the sewerage system. It also may be increased by industrial processes [42].
Contamination of heavy metals in the aquatic environment is very harmful since these elements cannot be degraded and they get accumulated inside the living organisms [43]. Residue from the industry is the major source through which these heavy metals get into the aquatic ecosystems, and their accumulation in water varies with the type of wastewater treatment used [44]. Effects known as deleterious can be observed when the metal particles are introduced into the water system [45, 46]. Different metals from the Amazon River (Brazil) and the Yukon River (Alaska) were analyzed in the solid-state only. Plants have the presence of these metals in water. In tissue, the concentration of several metals is slow, and their concentration should be kept in less range only as more concentration can be harmful to the biological development of the pant [47]. Through the food chain, fish contaminants can reach man [48]. Effluent from industries, water tank leakages, dumping beside marines, and due to radioactive waste and atmospheric deposition, are some sources of water contamination. Disposed of heavy metals and waste from industries they get accumulated in rivers and lakes thus causing harmful impacts on animals and humans. For suppression of the immune, reproductive failure and acute poisoning toxins are responsible [49]. Then there is direct damage to plant or animal nutrition at that time human health is affected. The pollutants that are polluting the water are killing marine organisms such as mollusks, marine birds, fishes, and other organisms that live in the sea [50].
With an increase in the population has created many issues and one of the issues is the pollution of water [38]. An increase in the population leads automatically leads to more generations of solid waste [51]. Both solid waste and liquid waste are deposited into the water without any treatment. Human excreta also contaminate the water. Thus, contaminated water leads to a generation of a large number of bacteria, which is a threat to human well-being [39]. Government is unable to supply vital requirements to the People because of the increase in the number of people. Facility for sanitization is more in urban areas as compared to rural areas. Plastic bag and waste are a major contribution to pollution. People throw the waste in plastic bags into water sources [24]. From the research, it was found that around three crore people of the population defecate in the open, while 77% population use flush and around 8% use the pit latrines. Urbanization can cause many infectious diseases. Overpopulation, unhealthy conditions, and dangerous drinkable water are these major health problems in urban areas. One-third of urban people are vulnerable to disease [37].
The population in rural areas is less but the use of fertilizers, pesticides, and eroded soil contaminates the water. When it rains the water from the surface runoff and that rainwater enters the nearby water resource and thus pollutes the existing water [52]. Agricultural runoff cases freshwater bodies’ eutrophication. Half of the lakes in the US are eutrophic. Phosphate has one of the major contributions to eutrophication. And the high concentration of phosphates promotes cyanobacteria and algae growth, which leads to the excessive use of the biologically dissolved oxygen inside the water [53]. Fertilizers that are too enriched with nitrogen decrease the dissolved oxygen in rivers and coastal zones thus bringing hazardous effects to the biota. Since 2006, the nitrogen in fertilizers is being controlled in America and Northwest Europe [54]. Like pesticides, which are used as pest control, these pesticides leach into groundwater, thus polluting groundwater. The pesticides that are water-soluble leach more and the sandy soil favors the process of leaching [55].
Small pollutants particles which are present in the air, get into the water stream through the rain, when it rains these particles come down and then with the flow of water enters into the sea, thus polluting the water there. These pollutants that are present in the air usually get from the burning of fossil fuels e.g. is CO2, which combines with water and produces sulfuric acid. Sulfur dioxide, which is formed via volcanic eruption and from industries, also gets attached to a water molecule to form the sulfuric acid. When coal is combusted then also sulfuric dioxide is produced and it is also produced from petroleum products. Just like this nitrogen dioxide also combines with the water and forms the nitric acid. And with the help of rainwater, they enter the water resources (Figure 2) [52, 56, 57, 58, 59].
Circulation of contaminants between environmental sources under the effect of atmospheric sources.
Heavy metals are present on the earth and thus they can enter the water system through various pathways and one of them is through mining sources. When it rains or through flowing water, it leaches heavy metals out from their geological formation. These processes get disturbed when manmade economic activities such as mining are done. Through these processes, the area that is already mined out gets exposed to water and air and this leads to the acid mine drainage (AMD). The low pH conditions associated with AMD mobilize heavy metals, including radionuclides where these are present [60].
Soil gets polluted with the presence of heavy metal on surface and underground water and the pollution rises when mined ores are discarded on the ground surface for manual dressing [61]. Due to the dumping over the surface, the metals get exposed to air and rain thereby generating huge AMD. If soil is polluted at that time, it gets into the plant tissue and gets accumulated there. And when those plants are grazed by animals and water is used for the drink from polluted waters, through there these heavy metals enter the body. Also, marine lives, which reproduce in contaminated water, also have the presence of heavy metals inside their body tissues, if they are lactating then inside their milk. As an overview, all organisms within a given ecosystem are contaminated via these pollutants through their food chains [62]. When nutrition from these contaminated vegetables is taken, the presence of heavy metals in those vegetables can lead to different chronic diseases. Toxic effects due to these heavy metals usually depend on the amount of concentration and the oxidative state of the particular heavy metals [63]. Heavy metals have a very dangerous impact as they are non-biodegradable in nature, have long biological half-lives, and have the potential to accumulate inside the body. Also, there are some heavy metals that are extremely toxic only because of their solubility. Fewer concentrations of heavy metals inside the food chain also show severe effects as there is no particular procedure through which these heavy metals pollutants can be extracted from the body of an organism. Nowadays presence of these toxic heavy metals is everywhere because of their extreme use in industries. In case of the wastewater, it contains a huge concentration of heavy metals, which create various health-related problems [64, 65].
Water from estuaries and freshwater is not polluted till now to some extent, but that water is also at threat of being polluted in the long term due to metal deposition because of human past activities [66]. The water in the river and lakes can be highly polluted depending on the volume of flow and proximity to the point sources. Due to the human civilization, the element content in water is raised. Such elements are cadmium, lead, mercury, zinc, and chromium. Unlike organic chemicals, there are some metals that cannot be converted into compounds with lesser toxicity, and one of its characteristics is the loss of biodegradability. Once the heavy metals enter the water system it gets redistributed throughout the column and gets accumulated in the sediments [67]. The sediments constitute a partial contribution to polluting the natural phenomena due to their activity and metal remobilization processes. Metal residues that are present in the contaminated surroundings have the flexibility to get bioaccumulated into the aquatic environment [68]. Growth in fish larvae and juveniles is rapid. But when these heavy metals enter they might inhibit the growth rate. The fish grows in length and bulk when given the right conditions, such as a specific temperature and an acceptable amount of food. Fish growth, on the other hand, may be impeded in water contaminated with toxicants, such as heavy metals. One of the most noticeable signs of metal toxicity in fish larvae is growth inhibition. As a result, the length and bulk of fish are indications of environmental conditions [69]. Heavy metals are introduced in liquid form and surface water constituents (carbonate, sulfate, organic substances humic, fulvic, and amino acids) cause the formation of non-soluble salts or complexes. Aquatic species are not expected to be harmed by these salts and compounds. Some of them sink and collect in the sediments at the bottom. A decrease in pH of water either due to acid rain or any other acidic incidents, due to the heavy metal’s deposition into the water column, causes aquatic biota to become poisonous. Low levels of heavy metals can also make chronic stress, through fish might not get dead but can cause them to lose weight and become smaller, reducing their capacity to compete for food and habitat [70]. Pollution poses a hazard to both freshwater and marine habitats. Heavy metal poisoning of water is a significant environmental hazard that has detrimental consequences for organisms who are exposed to it be that plant-animal or humans. Fish from freshwater are majorly exposed to various heavy metals, which are added into the water bodies through the different-different sources. Contamination of these heavy metals into aquaculture has intensified global issues because it shows a risk to fish and has harmful impacts on fish buyers [71]. There are three different modes through which heavy metals enter the fish. These methods are either through the gills of fish, by the body of the fish, or by the digestive tract of the fish. Heavy metals immediately enter the fish body through the gills, while the body surface takes time for uptaking of these heavy metals through this mode [72]. Mostly the metals get accumulated in the liver, kidney, and gills. In fishes, the muscles have most of the metals present there as compared to the other body parts of the fish. Too much accumulation of these heavy metals inside the fish organ can cause lesions and operative disturbances [73]. These heavy metals also interfered with the embryo’s shape and the metabolic processes of the fishes. Structural and functional defects throughout the development of the embryo resulted in fewer larvae hatching. Several freshly born larvae die shortly after hatching owing to lead and copper absorption [74, 75]. Heavy metals get into the fish through three routes: the first is via the fish gills, the second is through the digestive tract of the fish and the last one is through the body of the fish. The gills of fish are the area that is known for the primary metal intake from the contaminated water. On the fish gills, zinc accumulates. It suggests a depressing influence on tissue respiration, which leads to hypoxia and mortality. Zinc pollution also causes alterations in the structure of the lungs and heart [76]. Humans and fish are both affected by mercury. Brain damage, with postnatal and fetal problems, leads to abortions, congenital deformity, and development differences in young fry due to Monomethyl. Minamata illness and Hg poisoning (via methyl Hg) both showed considerable neurotoxicity [77]. Nickel is necessary for tiny amounts for the formation of RBC, but when its concentration gets increased, at that time, it becomes harmful or poisonous. Cd has been linked to an increase in blood pressure and cardiac illness in fish. Blood vessels damage, hemorrhages, and depletion of blood cell count of a fish are induced by Hg, from previous research. Anemia, eosinophilia, lymphocytosis, bronchial, and renal injuries can affect chromium levels in the blood [18]. Malformations in fish are caused by cadmium, nickel, mercury, chromium, lead, and arsenic. The accumulation of these heavy metals in excessive amounts causes a variety of physiological effects. Fin loss, gill underdevelopment, liver dysfunction, and fin function in fingerlings were all prevalent findings in the studies [78]. The harmful effects of heavy metals have the greatest impact on the death rate, reproduction, individual development rates, and physiological capacity of fish. There have been effects on physical functioning and chemical parameters in the tissues and blood of fish living in water that is polluted via metals. It has been reported that fish exposed to metals developed immune system defects, making them more susceptible to infectious infections and increasing their chances of dying (Figure 3) [79].
Harmful effects on the aquatic environment.
For the growth of plants, few HMs like As, Cd, Hg, Pb, and Se are not important as they do not perform any known physiological function in them. Others, such as Co, Cu, Fe, Mn, Mo, Ni, and Zn, are key elements that are required for regular plant development and metabolism, but their amounts can quickly exceed the appropriate levels, resulting in poisoning [80, 81]. Heavy metal concentrations in plants vary by plant species, and the efficiency with which various plants absorb metals is measured by plant absorption or metal transfer factors from soil to plant. An increased amount of Pb in agricultural soil decreases the productivity rate of the soil, and a less lead amount may hinder some important processes of plant, dark green leaves, withering of older leaves, stunted foliage, and brown short roots are poisonous indicators of photosynthesis, mitosis, and water absorption [82]. Heavy metals are poisonous and phytotoxic to plants, resulting in diseases such as chlorosis, poor plant development, and yield depression, as well as decreased nutrient absorption, plant metabolic problems, and a reduced capacity to fix molecular nitrogen in leguminous plants. Seed germination was gradually reduced in the presence of increasing levels of lead, it may be due to exposure to lead for a longer duration, some methods, such as leaching, chelation, metal binding, or microbe accumulation, have resulted in the neutralization of lead’s harmful effects [83]. Heavy metals such as Cd, Pb, and Ni even their small concentration in plants can be hazardous to them. Poisoning due to this heavy metal will result in the complex interplay between the primary unpleasant ions and additional necessary or non-essential ions. Metals affect the activity of enzymes by swapping metal ions from metal enzymes, as well as preventing plant growth [84]. Some exceptional metals are vital for plants, as they reveal their roles in the catabolism of plants and biosynthesis, together as cofactors for enzymes and as metabolic yields. For example, Zn, Fe, Cu, Cr, and Co are the important nutrients but when their amounts are increased, they become toxic. Comparatively, Pb and Cd have no effect, which is favorable to the plant and is solely lethal [85]. The most abundant hazardous elements in the soil are lead. Pb poisoning in the soil is caused by municipal sewage sludge discharge, mining and smelting operations, Pb-containing paints, paper and pulp, gasoline, and explosives. They do not have any role in the shape of the plant or their growth and photosynthetic process of the plant. Pb poisoning also inhibits enzyme action, creates an imbalance of the water, alters membrane permeability, and disrupts mineral feeding [86].
One of the main sources of contamination of the water is heavy metals, as it overwhelms the important species indirectly through biological chains or directly via chemical modifications in water. Three potential ways are there, through which heavy metals get into the fish body: though fish gills, through the body of the fish, and through the fish digestive tract. Gills are responsible for the immediate absorption of metals from the water, whereas the body surface is thought to have a smaller role in the intake of these elements in fish [87]. By altering the normal activities of numerous enzymes and metabolites, the accumulation of these heavy metals in the tissues causes significant biochemical, physiological, and histological changes in fish and other freshwater fauna. Fish are one of the most widely dispersed creatures in the aquatic ecosystem, and their susceptibility to metal poisoning may indicate the extent of metal pollution’s biological impact [88]. Heavy metals, such as As, Cd, Cu, Cr, Fe, Pb, Mn, Hg, Ni, Zn, and tin (Sn), are major contaminants that cause serious toxicity in fish. Due to the heavy metals, the physiological and biochemical functions both in tissues and in blood Carpi can be altered. The compounds of As and inorganic As, Cd, Ni, silica in its crystal form, beryllium, and its compounds are considered to be chemical carcinogens, which results in the development of cancer inside the fishes. The drop in hematological parameters indicated that the exposed fishes had become anemic as a result of Cr exposure. This dangerous heavy metal was released into the aquatic ecosystem via trash, causing severe anemia and changes in hematological parameters in the
Water pollution is a global problem, and the world’s population is suffering the consequences of tainted water. Living organisms are also affected by the polluted water very much and it is very harmful to the environment. Acute and choric illnesses are caused by heavy metal concentrations in drinking water that exceed the permissible limits set by several national and international organizations. These can range from nonfatal, such as muscle and physical weakness, to fatal, such as brain, nervous system, and even cancer. Water quality testing is necessary for the protection of human health and the environment.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
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\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
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\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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Energy capture as hydrogen via water electrolysis has been gaining tremendous interest in Europe and other parts of the world because of the higher renewable penetration on their energy grid. Hydrogen is an appealing storage medium for excess renewable energy because once stored, it can be used in a variety of applications including power generation in periods of increased demand, supplementation of the natural gas grid for increased efficiency, vehicle fueling, or use as a high-value chemical feedstock for green generation of fertilizer and other chemicals. Today, most of the cost and energy use in PEM electrolyzer manufacturing is contributed by the cell stack manufacturing processes. Current state-of-the-art electrolysis technology involves two options: liquid electrolyte and ion exchange membranes. 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With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"64843",title:"Polymer Nanocomposites with Different Types of Nanofiller",slug:"polymer-nanocomposites-with-different-types-of-nanofiller",totalDownloads:4184,totalCrossrefCites:21,totalDimensionsCites:64,abstract:"The development of polymer nanocomposites has been an area of high scientific and industrial interest in the recent years, due to several improvements achieved in these materials, as a result of the combination of a polymeric matrix and, usually, an inorganic nanomaterial. The improved performance of those materials can include mechanical strength, toughness and stiffness, electrical and thermal conductivity, superior flame retardancy and higher barrier to moisture and gases. Nanocomposites can also show unique design possibilities, which offer excellent advantages in creating functional materials with desired properties for specific applications. The possibility of using natural resources and the fact of being environmentally friendly have also offered new opportunities for applications. This chapter aims to review the main topics and recent progresses related to polymer nanocomposites, such as techniques of characterization, methods of production, structures, compatibilization and applications. First, the most important concepts about nanocomposites will be presented. Additionally, an approach on the different types of filler that can be used as reinforcement in polymeric matrices will be made. After that, sections about methods of production and structures of nanocomposites will be detailed. 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Due to their highly anisotropic shape and enormous index of refraction, they behave as optical antennae with improved absorption and emission properties, and thus better photovoltaic cell efficiency compared to a planar material with equivalent volume. Implying important advantages of reduced material usage and cost as well as due to its direct bandgap and its flexibility for designing solar cells, we choose to review III–V NWs. Their bandgap can easily be tunable for growing on the cheapest Si substrate. The recent developments in NW-based photovoltaics with attractive III–V NWs with different growth mechanisms, device fabrication, and performance results are studied. Recently, III–V NW solar cells have achieved an interesting efficiency above 10%. GaAsP NW has achieved 10.2%; InP NW has achieved 13.8%; GaAs NW has achieved 15.3%; and moreover the highest 17.8% efficiency is achieved by InP NW. While the III–V NW solar cells are much more vital and promising, their current efficiencies are still much lower than the theoretically predicted maximum efficiency of 48%. In this review, the chapter focused on the synthesis processes of III–V nanowires, vapor-liquid-solid growing mechanisms, solar light harvesting of III–V nanowire solar cells, and designing high-efficiency and low-cost III–V nanowire solar cells.",book:{id:"11461",title:"Advances in Nanowires Synthesis and Applications to Sensing Technologies \ufeff",coverURL:"https://cdn.intechopen.com/books/images_new/11461.jpg"},signatures:"Fikadu Takele Geldasa"},{id:"82660",title:"Organoclay Nano-Adsorbent: Preparation, Characterization and Applications",slug:"organoclay-nano-adsorbent-preparation-characterization-and-applications",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105903",abstract:"Organoclay has a tremendous impact on both fundamental studies and practical applications in numerous fields. In this context, this chapter investigates the performance of Organoclay in wastewater treatment. In particular, the adsorption of various hazardous substances has been reviewed. This study aims to give an overview of the preparation methods of Organoclay. The second purpose was to discuss the removal efficiency and reliability of various pollutants by organoclay. The third goal discussed the isotherms and kinetics used for the data interpretation. This work revealed that the characteristics of Organoclay depend mainly on the type of clay used and the nature of the intercalated surfactant. Sorption efficiency was found to depend on the nature of Organoclay, type of pollutant, pH, contact time and the concentration of pollutant.",book:{id:"11755",title:"Nanoclay - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11755.jpg"},signatures:"Kawthar Yahya, Wissem Hamdi and Noureddine Hamdi"},{id:"81789",title:"Processing of Graphene/Elastomer Nanocomposites: A Minireview",slug:"processing-of-graphene-elastomer-nanocomposites-a-minireview",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104849",abstract:"Since the isolation and identification of graphene, the academic and industrial communities are utilizing its superior properties. This minireview deals with the processing of graphene-based fillers/elastomer nanocomposites. The incorporation of graphene in an elastomeric matrices has significant effects on the properties of nanocomposites. The dispersion of graphene in elastomers is discussed. The processing of graphene/elastomer nanocomposites is discussed. The mechanical properties of the elastomeric matrix can be enhanced due to the presence of graphene. In this review and due to space limitations, we will present an example of improvements in the mechanical characteristics of graphene/styrene-butadiene (SBR) elastomer nanocomposites.",book:{id:"10825",title:"Nanocomposite Materials",coverURL:"https://cdn.intechopen.com/books/images_new/10825.jpg"},signatures:"Mohammed A. Sharaf and Andrzej Kloczkowski"},{id:"82693",title:"CuO and MWCNTs Nanoparticles Filled PVA-PVP Nanocomposites: Morphological, Optical, Dielectric, and Electrical Characteristics",slug:"cuo-and-mwcnts-nanoparticles-filled-pva-pvp-nanocomposites-morphological-optical-dielectric-and-elec",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105810",abstract:"Copper dioxide (CuO) nanoparticles and multiwall carbon nanotubes (MWCNTs)-filled poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) blend matrix (50/50 wt%)-based polymer nanocomposites (PNCs) have been prepared employing the solution-cast method. The X-ray diffraction explores the semicrystalline morphologies of these PNCs. The FTIR, SEM, and AFM measurements of PNCs expose the development of the miscible mix, polymer-polymer and polymer-nanoparticle interactions, and the influence of CuO and MWCNTs nanofillers on the morphology aspects on the main chain of PVA/PVP blend. The nanofiller loading for x = 14 wt% in the PVA–PVP blend matrix significantly enhances the crystalline phase, diminishing the optical energy gap to 2.31 eV. The DC conductivity is found to be maximum for x = 14 wt% loading concentration. The dielectric and electrical characteristics of these PNCs are investigated for an applied frequency range from 1 kHz to 1 MHz. The dielectric permittivity values increase substantially, owing to the decrease in the nano-confinement phenomenon at low frequency. The rise in applied frequency reduces dielectric permittivity and impedance values and enhances AC electrical conductivity. These PNCs having good dielectric and electrical characteristics can be used as frequency tunable nano-dielectric material in electronic devices.",book:{id:"11464",title:"Carbon Nanotubes - Recent Advances, New Perspectives and Potential Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11464.jpg"},signatures:"Hassan A.H. 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Taken together, iron oxide nanoparticles are bioactive materials and may perform particular biological function in life activity.",book:{id:"10824",title:"Iron Oxide Nanoparticles",coverURL:"https://cdn.intechopen.com/books/images_new/10824.jpg"},signatures:"Lizeng Gao"},{id:"82277",title:"Application of Iron Oxide in Supercapacitor",slug:"application-of-iron-oxide-in-supercapacitor",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.105001",abstract:"Iron oxide nanostructures have been considered very promising material as electrode in electrochemical energy storage devices because of their lower cost of synthesis and high theoretical charge storage capacity. Iron oxide nanoparticles and their nanocomposites have performed excellent in supercapacitor. Iron oxide as negative electrode has extended the working voltage window of a supercapacitor. The main problems associated with iron oxide based electrodes are their poor electrical conductivity and cycle stability. Therefore, a conductive carbon matrix has been added to the iron oxide based electrodes to improve the electrochemical performance. In this chapter, recent progress on iron oxide and its composite with different materials as electrode in supercapacitor is summarized. The various synergistic effects of nanocomposites and compositional engineering to enhance the electrochemical performance of iron oxide are also discussed.",book:{id:"10824",title:"Iron Oxide Nanoparticles",coverURL:"https://cdn.intechopen.com/books/images_new/10824.jpg"},signatures:"Rajan Lakra, Rahul Kumar, Parasanta Kumar Sahoo, Sandeep Kumar and Ankur Soam"}],onlineFirstChaptersTotal:26},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. 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She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. 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He is also Member of the Laboratory of genetic, animal and feed resource and member of Animal science Department of INAT. He graduated from Higher School of Agriculture of Mateur, University of Carthage, in 2002 and completed his masters in 2006. Dr. M’HAMDI completed his PhD thesis in Genetic welfare indicators of dairy cattle at Higher Institute of Agronomy of Chott-Meriem, University of Sousse, in 2011. 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Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). 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He is an academic staff member of the Department of Reproduction and Artificial Insemination, Selçuk University, Turkey. He manages several studies on sperms and embryos and is an editorial board member for several international journals. His studies include sperm cryobiology, in vitro fertilization, and embryo production in animals.",institutionString:"Selçuk University, Faculty of Veterinary Medicine",institution:null},{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",biography:"Yusuf Bozkurt has a BSc, MSc, and Ph.D. from Ankara University, Turkey. He is currently a Professor of Biotechnology of Reproduction in the field of Aquaculture, İskenderun Technical University, Turkey. His research interests include reproductive biology and biotechnology with an emphasis on cryo-conservation. He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. Aljaser",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"428600",title:"MSc.",name:"Adriana",middleName:null,surname:"García-Alarcón",slug:"adriana-garcia-alarcon",fullName:"Adriana García-Alarcón",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428599",title:"MSc.",name:"Gabino",middleName:null,surname:"De La Rosa-Cruz",slug:"gabino-de-la-rosa-cruz",fullName:"Gabino De La Rosa-Cruz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428601",title:"MSc.",name:"Juan Carlos",middleName:null,surname:"Campuzano-Caballero",slug:"juan-carlos-campuzano-caballero",fullName:"Juan Carlos Campuzano-Caballero",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}}]}},subseries:{item:{id:"95",type:"subseries",title:"Urban Planning and Environmental Management",keywords:"Circular Economy, Contingency Planning and Response to Disasters, Ecosystem Services, Integrated Urban Water Management, Nature-based Solutions, Sustainable Urban Development, Urban Green Spaces",scope:"