Chapters authored
Pathopysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem
Part of the book: Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture
Biomechanic and Hemodynamic Perspectives in Abdominal Aortic Aneurysm Rupture Risk Assessment
Abdominal aortic aneurysms (AAAs) pose a significant source of mortality for the elderly, especially if they go on undetected and ultimately rupture. Therefore, elective repair of these lesions is recommended in order to avoid risk of rupture which is associated with high mortality. Currently, the risk of rupture and thus the indication to intervene is evaluated based on the size of the AAA as determined by its maximum diameter. Since AAAs actually present original geometric configurations and unique hemodynamic and biomechanic conditions, it is expected that other variables may affect rupture risk as well. This is the reason why the maximum diameter criterion has often been proven inaccurate. The biomechanical approach considers rupture as a material failure where the stresses exerted on the wall outweigh its strength. Therefore, rupture depends on the pointwise comparison of the stress and strength for every point of the aneurysmal surface. Moreover, AAAs hemodynamics play an essential role in AAAs natural history, progression and rupture. This chapter summarizes advances in AAAs rupture risk estimation beyond the “one size fits all” maximum diameter criterion.
Part of the book: Abdominal Aortic Aneurysm