Safety is considered a top priority due to its significance in safeguarding human lives and properties, especially in high-risk industrial sectors such as aviation, oil and gas, construction, transportation, steel manufacturing, and mining industries. These industries are plagued by workplace injuries, illnesses, and fatalities because of the dangerous work environments. As such, it is very vital to integrate safety into every work process in any industrial environment just like quality is built into products and services. It is important to establish and execute an effective safety management system to prevent the risks of irreversible accidents. This chapter begins with a background to safety management in industrial engineering and a discussion of the various issues of industrial safety management. It follows with an extensive description of existing and commonly used safety performance measurement methods. Several case studies are used to explain the methods and explore the important application areas relevant to most industrial sectors. The techniques and tools for safety data collection, analysis, and sharing are introduced together with their applications for safety management. The last section explains how emerging technologies can be implemented in most industrial sectors to enhance safety management.