Examples of tested hydrogels based on sodium alginate as drug delivery systems.
\\n\\n
Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\\n\\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\nThank you all for being part of the journey. 5,000 times thank you!
\\n\\nNow with 5,000 titles available Open Access, which one will you read next?
\\n\\nRead, share and download for free: https://www.intechopen.com/books
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
\n\n"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
\n\n\n\nDr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\n\nThank you all for being part of the journey. 5,000 times thank you!
\n\nNow with 5,000 titles available Open Access, which one will you read next?
\n\nRead, share and download for free: https://www.intechopen.com/books
\n\n\n\n
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Advances in tissue regeneration are possible due to development in the areas of engineering of the cells, materials and tissue architecture. Cell engineering mainly use genetic tools, mesenchymal stem cells or indecent pluripotent stem cells. Engineering of materials developed novel chemistries, growth factors and biomechanical conditions, whereas engineering of tissue architecture proposed novel techniques for manufacturing of scaffolds for cell growth, i.e., by using decellularised organs, 3D printing and self-assembly structures [1]. These three research areas are crucial for progress in tissue healing, and they must be compatible with each other. The stem cells will not grow properly on toxic material or in toxic biochemical and biomechanical conditions. For proper tissue healing, micromovements between the tissue structures—cells and extracellular matrix—are crucial. Like in bone growth, Wolff’s law states:
Hydrogels, as cross-linked polymeric networks, contain hydrophilic groups that promote swelling due to interaction with water. They have been in use for clinical applications since the 1960s, initially for use in ocular applications including contact lenses and intraocular lenses due to their favourable oxygen permeability and lack of irritation leading to inflammation and foreign body reaction, which was observed with other plastics. Hydrogels used in regenerative applications can be based on naturally or synthetically derived polymers. By most definitions, native tissues, particularly the extra-cellular matrix, are hydrogels and derivatives of these and other naturally based systems which are in widespread use [4, 5]. In a three-dimensional, cross-linked network of hydrophilic polymer, hydrogels offer properties such as flexibility in mechanical properties, biocompatibility, capacity to retain large ratio of solvent and ability to be prepared in an injectable form among others. These have made them as a potential candidate for use in biomedical and pharmaceutical applications such as tissue engineering [22, 24].
Molecules used for fabricating hydrogels range from natural polymers, such as dextran, gelatine and hyaluronic acid (HA), to synthetic polymers, such as polyethylene glycol (PEG), polyacrylamide (PAAm) and polyvinyl alcohol (PVA). Natural and synthetic polymers have their own advantages such as biocompatibility and high mechanical strength, respectively. Different cross-linking methods for 3D construction of hydrogel scaffolds include chemical cross-linking with covalent bond, electrostatic interaction, hydrogen bond interaction and self-assembly of polymer chains [6].
Hydrogels from natural polymers have a great potential in regenerative medicine because of their biocompatibility, biodegradability, mechanical properties, bioresorption ability and relative low cost. Among them, sodium alginate, a polysaccharide derived from brown seaweed, is widely investigated and used in biomedical applications. Alginate is highly hydrophilic and able to absorb wound exudate maintaining moist microenvironment. Alginate dressings are also useful as delivery platform in order to provide a controlled release of therapeutic substances (e.g., pain relieving and antibacterial and anti-inflammatory agents) [7], which will be discussed in the following sections.
Sodium alginate is classified in the group of hydrogels used in regenerative medicine and medical technology applications, and it is the second most abundant polysaccharide on earth, derived from seaweed, and contains β-D-mannuronate (M blocks) and β-L-guluronate subunits (G blocks) bonded with 1,4 linkage. The mechanical properties of these gels can be modulated depending on the divalent cation used to achieve cross-linking. Bivalent and trivalent cations such as Ca2+, Ba2+, Mg2+, Fe2+ and Al3+ covalently bind alginate G blocks to form a three-dimensional structure called “egg box”. For example, the use of barium or strontium instead of calcium leads to more rigid gels. M and G blocks can be combined in different sequences or alternately ensuring that bivalent cation cross-linked polymer chains form a 3D structure capable of binding large amounts of water, drugs and bioactive substances supporting tissue regeneration. Results of studies revealed that sodium alginate cross-linked with calcium ions stimulates proliferation and differentiation of osteoblasts in vitro [4, 38, 61].
As the largest organ of the human body, the skin plays a pivotal role in maintaining homeostasis as well as protecting the internal organs from the external environment. Cutaneous injuries, especially chronic wounds, burns and skin wound infections, require long-term treatment. In the United States, chronic wounds affect 6.5 million patients, with about 18% of diabetic patients over the age of 65 suffer from non-healing foot ulcers [36]. Wound healing is a complex and highly regulated physiological process that involves various cell types (i.e., immune cells, endothelial cells, keratinocytes and fibroblasts) and pathways, activated and coordinated in order to restore the tissue integrity and homeostasis [7, 8]. In the proliferation phase of a wound formation, epithelialisation occurs, and newly formed granulation tissue consisting of endothelial cells, macrophages and fibroblasts begins to cover and fill the wound area by producing new extracellular matrix (ECM). The presence of the new extracellular matrix is crucial for proper healing because it provides conditions for sustaining cells and blood vessels, which provide nutrients needed to restore the tissue integrity and homeostasis [9]. The extracellular matrix also serves as a porous and pliable scaffold for supporting the movement of cells, nutrients and growth factor through the wound environment. Studies on chemical composition of ECM during wound healing indicate that the deposition of a number of matrix components is different in chronic and acute wounds. Therefore, drug-incorporated scaffolds are particularly promising for synergistically accelerating the healing process of chronic wounds [36, 37].
Summa et al. [7] examined wound-healing potential of the hydrogel films containing sodium alginate (NaAlg) 3 g/100 ml of H2O with the addition of 10% of the antiseptic povidone iodine (PVPI). The films were tested on a wound model on male mice, and the results showed significant reduction of the wound area and enhancement of re-epithelialisation in comparison to two groups: control and commercial products. The authors reported a significant reduction of the unhealed area after 3 days, and the wound closure was achieved within 12 days, which was more rapid and efficient than the other two groups. Histological results confirmed that NaAlg/PVPI films cause positive architectural changes on cellular level during the new tissue formation; the distance between tips of migrating epithelial tongues was the smallest in comparison to the other two groups. NaAlg/PVPI hydrogel films and their polysaccharide chains organised in a 3D structure on micro level enhance the wound healing and induce cell proliferation, whereas the presence of antiseptic povidone iodine in the films prevent bacterial infections. The authors did not examine the biomechanical properties of the NaAlg/PVPI films, so the elasticity and strength of these films are unknown, but the obtained results show that these films have biomechanical properties similar to mice skin.
Alginate-based hydrogels for wound healing with antibacterial components were also presented by Kaczmarek-Pawelska et al. [11]. Alginate hydrogel discs were obtained by cross-linking of sodium alginate solution with 0.5 M CaCl2. Moreover, the researchers examined different alginate concentrations, 0.10, 0.15 and 0.20 mg/ml H2O, and two antibacterial agents: metronidazole and silver nanoparticles (AgNP). The results showed that the obtained hydrogels have mechanical characteristics similar to the human skin, so the material is biomechanically compatible and proper for wound healing, but the value of Young modulus decreased with increasing sodium alginate concentration from 8 MPa for 0.1 mg/ml to 1.2 MPa for 0.2 mg/ml of sodium alginate. Due to the research of Edwards, the Young modulus value of the skin is from 0.3 to 30 MPa [12]. The high range of this value is caused by the individual features of the samples donor. Mechanical tests revealed that for the hydrogel samples containing silver nanoparticles, the mechanical properties are similar for each sodium alginate concentration. The difference in sodium alginate concentration determines the cross-linking level, when the cross-linking agent (CaCl2) concentration is the same in every case examined. The cross-linking level influences the sample elasticity and elongation under loading. Antibacterial tests revealed that hydrogels with the addition of metronidazole and AgNP inhibits the bacterial growth after 18 h in comparison to control pure sodium alginate hydrogel. In the case of Gram-negative
In the case of the sodium alginate hydrogels, the antibacterial activity and biocompatibility of the sodium alginate hydrogels also depend on the type of cation used as a cross-linking agent. Zhou et al. carried out in vitro and in vivo studies of the different cross-linking agents and examined copper, zinc, strontium and calcium ions. The results showed that zinc-cross-linked hydrogel had a spectrum of antibacterial activities, cell viability, mechanical strength and the ability of wound closure by promoting fibroblast migration, vascularisation, collagen deposition and the formation of granulation tissue. Wound healing (Figure 1) was compared in the six groups of rats during 21 days; it was found that ion-cross-linked hydrogels could accelerate the wound repair on rat model, especially the zinc- and strontium-cross-linked hydrogels [18].
The area of wound healing and general wound observation after treating with the ion-cross-linked hydrogels, nonionically cross-linked sodium alginate hydrogels such as control group and petrolatum gauze group at different times [
Wichai et al. [10] proposed another wound dressing containing sodium alginate. The authors obtained membranes from bacterial cellulose (BC) incorporated with sodium alginate (AG), chitosan (CS) and copper sulphate (Cu). Moreover, they also examined how different amounts of sodium alginate and chitosan influence the membrane properties. Both of the polymers were used in different concentrations: 0.2, 0.4, 0.6, 0.8 and 1.0% w/v. The results showed that the presence of sodium alginate increased the swelling ratio, but the tensile strength decreased with high alginate concentration in the membrane. Alginate in the BC/AG composite enhanced the molecular motion of BC and perturbed the hydrogen bond of the BC composite. Furthermore, it can be as the cause of the reduced mechanical strength. Cytotoxicity of the membranes was evaluated in tests with mouse fibroblasts (L929) and human dermal fibroblasts (HDFa), in comparison to commercially available wound dressings: Acticoat®, Askina® and BluRibbon®. The results of these tests show that BC/AG/Cs-Cu composite membranes appear to display excellent antibacterial activity against
Novel dressings for skin injury healing contain alginate alone or, much more often, as a component of a multicomponent material, with, e.g., polyvinyl alcohol [13, 14, 19, 20], gelatine [13, 20], silk fibroin [15, 16], hyaluronic acid [17] or even graphene oxide [21]. These components are added to increase the mechanical properties, hydrophilicity and adhesion of the cells to the scaffolds. Moreover, to target cell response, the additives like collagen [13] and hormones such as triiodothyronine may be added [20].To support the healing process at the cellular level and recreate favourable architecture for the cell proliferation, the hydrogel scaffolds are produced by electrospinning. The high surface-to-volume ratio of nanofibers has been proven to be beneficial for the loading and delivery of drugs for wound recovery. Sobhanian [13] extracted collagen from rat tail and successfully grafted it on a nanofibrous scaffold from polyvinyl alcohol/gelatine/alginate. Modification of the scaffold with collagen increased its hydrophilicity and adhesion of the fibroblast cells. Collagen grafting resulted in the improved cell viability and proliferation on the scaffold. The obtained results confirmed that the as-prepared scaffold is hydrophilic and had acceptable bio-response and tensile properties. Tang et al. [14] produced and examined polyvinyl alcohol/alginate electrospun membrane with the addition of honey as an ancient natural wound-healing agent. The addition of honey in the nanofibers efficiently inhibited the growth of both Gram-positive bacterium (
The advance in 3D bioprinting can offer precise cell patterning in predefined spatial locations, which enables the recapitulation of architectural organisation of native skin. However, the current bio-inks for skin cell printing are mostly alginate, collagen, fibrin or their mixture, which remain suboptimal [36].
Articular cartilage is a highly specialised and organised tissue that lines the ends of long bones and is integral to the functioning of all joints. It provides lubrication and mechanical strength to resist compressive and tensile forces that are essential for weight-bearing and movement. The cartilage has a unique extracellular matrix, which is comprised of an interpenetrating network of collagen and negatively charged proteoglycans and contains only one cell type—chondrocytes. Defects in cartilage do not heal properly because the cartilage has a limited regenerative capability [26]. Regeneration of articular cartilage remains an unmet medical need, which imposes a heavy burden on global economy and on the health-care community. Articular cartilage repair is still a huge challenge for researchers and clinicians. Articular cartilage defects mainly result from mechanical trauma (e.g., sports injuries). Patients with acute traumatic joint injuries have a higher chance of developing posttraumatic osteoarthritis, a degenerative condition that results in severe pain and disability, eventually requiring a total joint replacement [29]. Similar to cartilage, hydrogels retain a large portion of water, which provides lubrication and decrease of coefficient of friction (COF). The presence of water also plays an important role in the mechanical behaviour of the hydrogel structure [23].
Arjmandi and Ramezani [22] proposed and examined hybrid hydrogel-based on alginate (ALG)-polyacrylamide with the addition of silica nanoparticles (SiNP), as a candidate for cartilage replacement. They proved that its mechanical properties result from the structure of the ALG/PAAm hydrogel. The presence of covalent cross-links between two entangled polymer chains, between amine and carboxyl groups of PAAm and ALG, respectively, implies the load sharing of both networks. Alginate forms a short chain that can dissipate strain energy via recoverable breaking of ionic cross-links, meaning that after the unloading, the ionic cross-linking can be reformed, thus will be healing the damage, while the long-chained polyacrylamide network remains intact, contributing to stabilisation of the structural deformation. Moreover, the silica nanoparticles, located in a three-dimensional hydrogel structure, enhance mechanical properties and also encourage cell proliferation. Hydrogel SiNP-ALG-PAAm showed ultralow COF, coupled with high wear resistance, and tunable elastic and viscoelastic behaviour suggesting these biomaterials as promising candidates for use as a cartilage replacement.
The biomechanical properties of the hydrogels come from a combination of compositions of different factors and cross-linking levels, but they also can be determined by molecular weight and chemical properties of the hydrogel. This relationship was described by Fenbo et al. [25], Lee et al. [27] and Chen et al. [28]. It was found that hydrogels formed from alginate exhibited faster stress relaxation, which facilitated the promotion of cartilage matrix formation by chondrocytes. Moreover, 3D microenvironment, especially the elastic and relaxation moduli of the cell culture matrix, can regulate the metabolic properties of the living cells. Authors improve that molecular weight and chemical properties of the polymers used for the cell culture matrix influence on the three-dimensional cell culture system. Fenbo et al. examined high-molecular-weight alginate/chondroitin sulphate (CS) and low-molecular-weight ALG/CS (B) cross-linked by strontium. The dynamic rheology results suggest that the storage and loss moduli increase with the increase of molecular weight of alginate applied during fabrication. Cell results revealed that chondrocytes encapsulated with alginate hydrogels exhibited the best results on maintaining cell viability and inhibiting cell death [25].
Also the presence of the bioactive proteins placed in hydrogels based on sodium alginate plays a role in regeneration of the articular cartilage. Ruvinon et al. obtained injectable growth factor-loaded affinity-binding alginate hydrogel [29]. They were the first to conduct the evaluation of acellular and injectable growth factor-biomaterial combination therapy for the treatment of articular cartilage defects with a 6-month follow-up period in a large animal model. As growth factors, they use TGF-β1 and BMP-4, which were conjugated with alginate sulphate obtained from sodium alginate. Macroscopical and histological assessment of the cartilage defects treated with growth factor affinity-bound hydrogel showed effective reconstruction of articular cartilage layer, with major features of hyaline tissue, such as a glossy surface and cellular organisation. Physical nature of the applied hydrogel ensured its shear resistance, seamless integration and topographical matching to the surroundings and opposing articulating surface [29].
A great potential in articular cartilage regeneration has also a mixture of alginate with collagen as a bio-ink for 3D cell printing. Yang et al. [31] printed scaffolds and compared properties and biocompatibility in vitro of three types of the bio-ink: sodium alginate (SA) alone, sodium alginate with collagen type I (COL) and sodium alginate with agarose (AG). The results showed that the mechanical strength was improved in both SA/COL and SA/AG groups compared to SA alone. The addition of COL or AG has little impact on gelling behaviour, demonstrating the advantage as bio-inks for 3D printing. Among the three scaffolds, SA/COL could distinctly facilitate cell adhesion, accelerate cell proliferation and enhance the expression of cartilage-specific genes and may be a promising 3D bioprinting bio-ink for cartilage tissue engineering [31].
Alginate hydrogels have also a great potential in cartilage healing when mixed with hyaluronic acid [30, 32, 33, 34, 35]. What deserves special attention is the research results. An et al. [32] presented hyaluronic acid-alginate hybrid hydrogel modified with biomimetic peptides. They enrich hydrogels with RGD peptide, which is widely used for enhancing cell-matrix interactions, and HAV peptide to increase cell-cell interactions. The authors prove that the precise control of cell-cell interactions using a scaffold is essential to regulate the cell phenotype and chondrogenic differentiation. Furthermore, the combination of these two peptides in hyaluronic acid-alginate hydrogels had a synergistic effect on the chondrogenesis of encapsulated chondrocytes, and the presented biomaterials are potentially useful for the tissue, especially cartilage regeneration [32].
The bone is a typical complex tissue with hierarchical structure that consists of approximately 70% of nano-hydroxyapatite (HA,Ca10(PO4)6(OH2)) and 30% of collagen by weight. Water (with some dissolved non-collagenous organic matter) is the third elementary component. The ratio of volume and weight fractions of hydroxyapatite/collagen/water is not constant and is an individual characteristic. Among the natural polysaccharides, alginate is widely used as a biomaterial for bone tissue engineering next to chitin and chitosan. Alginate, due to it scaffold-forming ability, is a promising material for tissue engineering [38].
The biomechanical bone system is complicated; therefore, the requirements for treatment systems are high. The perfect biomaterial for bone healing should be biocompatible, have a sufficient surface area, be nontoxic with three-dimensional structure and have porosity with pore size more than 100 μm. The biomaterial should also support cell adhesion, migration and proliferation. For proper tissue growth, biomaterial should improve vascularisation that is crucial for cell migration and proliferation into the desired direction. Moreover, it should be biodegradable, be a carrier for drugs and growth factors and have mechanical properties equivalent to cortical bone [38].
Current literature report presented by Purohit et al. [39] describes fabrication of a nanocomposite scaffold of graphene oxide (GO), gelatine and alginate (GA). The properties of the obtained scaffold qualify it as a material supporting bone healing. The presence of graphene oxide in the gelatine-alginate scaffold increases its biomechanical strength. Hydrogels without the addition of graphene oxide have a compressive strength of 30 MPa, while those containing GO 44 MPa. Moreover, the presence of graphene oxides enhanced the hydrophilicity of the scaffold and provided slow degradation (~30% in 28 days). In vitro studies confirmed that an osteoblast cell line (MG-63) growth over the nanocomposite scaffolds revealed an enhancement in the cell attachment and proliferation as compared to the gelatine-alginate scaffold.
Scaffolds are crucial for bone tissue engineering since their compositions and properties could significantly affect the seeded cell behaviour. Zheng et al. [43] developed an interpenetrating network hydrogel by utilising Ca2+ from calcium silicate (CS) to simultaneously cross-link silk fibroin (SF) and sodium alginate. Obtained scaffolds, with different contents of calcium silicate, were systematically evaluated by physical and in vitro characterisations. Researchers found that calcium silicate inside the porous structure of hydrogel scaffolds enhance hydrophilicity, degradation, compression resistance and bioactivity. The scaffolds containing higher amount of calcium silicate have better biocompatibility and promote the osteogenic differentiation in vitro.
Sodium alginate can be easily manufactured in microspheres with three-dimensional net structures using cross-linking with calcium ions [40]. Hydrogels formed as microspheres possess some advantages for use in biomedical applications because of the larger specific surface area that can improve cell adhesion, proliferation and drug delivery. Bi et al. [40] obtained sodium alginate microspheres with the addition of chitosan (CS) and hydroxyapatite. Doxorubicin hydrochloride (Dox) was used as a drug model to study the drug loading behaviour of HA nanoparticles and hydrogel composite microspheres. In vitro examinations confirmed that the prepared HA/SA/CS/Dox drug-loaded microspheres support regeneration of the bone defects and also provide drug delivery with control of the drug release. However, the actual process of the material in vivo has not been studied. The results indicate that the hydroxyapatite/alginate hydrogel microsphere has potential in bone healing and as a drug carrier [40].
A combination of hydroxyapatite, in nano-form (nHA), and sodium alginate was also recently examined by Nabavinia et al. [45]. Nano-hydroxyapatite combined with sodium alginate showed a statistically significant impact on swelling reduction and improvement of stability and mechanical strength of hydrogels, respectively. The authors mixed SA/nHA with gelatine, to improve the cell adhesion and proliferation activities. In the research, the microcapsules were formed from solutions with a different content of each ingredient. The results show that the addition of the gelatine significantly increased swelling ratio at initial phase of incubation, similar to the degradation rate. Young modulus of the microcapsules was 0.19 MPa ± 0.02. Swelling ratio of examined hydrogel was 52% ± 8 for 24 h, and degradation rate of microspheres was 12% ± 4 (96 h). The addition of nano-hydroxyapatite in hydrogel significantly increased proliferation of the microencapsulated osteoblast cells. Examinations of cell surface receptors and protein adsorption onto hydrogel inhibit high cell proliferation and activity. The presence of gelatine in hydrogel microcapsules increases the cell proliferation, and they may be proper to build blocks for modular bone tissue [45].
Another use of the complex of sodium alginate and chitosan as a material for bone regeneration is proposed by Lee et al. [41]. The authors developed an injectable material, new calcium phosphate cement (CPC) system, incorporated with chitosan/alginate complex. Hydrogel biomaterial was produced by the interaction between cationic and anionic polymers: chitosan and alginate. In the studies, the bioactivity of cement without the polymer addition was compared with the cement containing the mixture of alginate and chitosan. Both of the cements were implanted in a rabbit femoral head defect model for 1 and 3 months. After 3 months of implantation, micro-computed tomography revealed better bone formation after implantation of cement that contains polymers than without it. The results indicate the potential value of the CPC system containing alginate-based polymer complex as an injectable bone substitute. The obtained cement system, based on chitosan/alginate mixture, may also serve as a drug carrier for faster bone healing [41].
Also a novel bone cement was presented by Shi et al. [46]. Authors use two calcium-binding agents, citric acid (CA) and sodium alginate. They were mixed with α-tricalcium phosphate (α-TCP) cement to improve the physicochemical properties of a novel biomaterial. The combination of citric acid and sodium alginate accelerated the binding of cement, increased its mechanical properties, delayed the process of hydration and prevented the formation of unclean earlandite phase. The results show that sodium alginate-citric acid hydrogel networks provided a strong cohesive action through the tight chelation with calcium ions during the hydration process of bone cements [46].
Macroporous biomaterials prepared from sodium alginate were proposed by Catanzano et al. [44] and Park et al. [42]. The first team of scientists designed natural bioactive scaffolds mimicking bone tissue. These bioactive scaffolds have to possess physicochemical properties suitable to address biological response towards newly formed bone tissues. Authors improve that the scaffold porosity and pore size play a crucial role in cell migration, adhesion and proliferation; thus they increase the cell-material surface interaction area and induce osteogenic signals transmission between cells. The authors proposed the development of macroporous alginate foams (MAFs) of porous and well-interconnected structure, useful to enhance growth and osteogenic differentiation of human mesenchymal stem cells (hMSCs) [44]. The second team [42] synthesised bio-ink, based on sodium alginate, alginate sulphate and a growth factor—bone morphogenetic protein 2. Authors used alginate sulphate, because it is a structural mimic of heparin and can strongly bind with the growth factors to prolong their activities. The exanimated mixture of alginate/alginate sulphate had good rheological properties that were not changed, after the addition of alginate sulphate, so it is proper to be used in 3D printing to obtain a structure with appropriate porosity. The bio-inks containing alginate sulphate displayed greater and more prolonged BMP-2 activities than the control bio-ink containing alginate only. Moreover, alginate/alginate sulphate bio-inks exhibited an improved retention of bone morphogenetic protein 2 in 3D-printed scaffolds. An optimal composition of alginate/alginate sulphate 3D-printed constructions to stimulate osteoblastic proliferation and differentiation in vitro is 3% alginate and 2% alginate sulphate [42].
This paper describes the use of hydrogels based on sodium alginate as a material for the regeneration of specific tissues. Hydrogels were often enriched with an active substance to induce a specific tissue reaction, and they may also be classified as drug delivery systems (DDSs). But the largest group of drugs is not delivered directly to the tissue, but via oral or inhalation routes.
Poor aqueous solubility is a major problem faced in the formulation of active pharmaceutical ingredients, and it causes poor bioavailability. Although several formulation strategies have been proposed to solve this problem, a modest success has been achieved in meeting the requirements of commercially viable drug delivery systems. Therefore, extensive research on the development of optimum DDSs is still necessary. Nanoscale colloidal carrier systems developed from natural compounds such as lipids, proteins and polysaccharides for encapsulation of poorly soluble drugs have been promisingly successful recently [48].
Many drug delivery systems are still in the research phase. Table 1 shows an overview of the latest achievements and DDSs development on the basis of sodium alginate.
Examples of tested hydrogels based on sodium alginate as drug delivery systems.
A novel DDSs for pulmonary drug delivery was proposed by Athamneha et al. [47]. As the authors declare, no hybrid formulations based on hyaluronic acid and alginate have been developed for inhalation routes so far. The researchers prepared porous aerogel microspheres consisting of the mixture of alginate and hyaluronic acid. Authors examined the mixture and alginate alone to improve aerodynamic properties of microspheres, to be delivered in the lower respiratory tract. The particles were prepared via the emulsion-gelation process with subsequent supercritical CO2 drying. Mixture of hyaluronic acid and alginate showed positive effect, prevented particle agglomeration and also improved biodegradation. The microsphere properties result from the fact that there is a hydrogen bond between carboxylate groups of ALG and the amide of the N-acetyl-D-glucosamine, which prevents the separation of components from the microsphere structure. The physicochemical and aerodynamic properties of the microspheres provided their potential suitability as a drug carrier for the pulmonary tract [47].
This chapter summarises the most frequent uses of sodium alginate in regenerative medicine and the studies on tissue regeneration. Sodium alginate is mainly used in medical devices for healing of wounds, scars, injuries of the bones, regeneration of joint cartilage, scaffolds for the cell growth and as a carrier of drug. The latest literature describes the effects of laboratory tests and in vivo, which confirm the validity of its use as a biomaterial. But there are more reports on the use of sodium alginate as a material for healing of other tissues as well. Sodium alginate is rarely used alone; most commonly it can be found in a mixture with other polymers, such as hyaluronic acid and polyvinyl alcohol, even with graphene oxide. Alginate-based hydrogels, due to their 3D polymer structure, support tissue regeneration on macro-, micro- and nanoscales. But due to its unique properties, sodium alginate is a substrate with a great potential as a hydrogel, not only in regenerative medicine but also in many different spheres of life.
This work has been financially supported by the Polish National Science Center grant 2016/21/B/ST8/01972.
The author declares that she has no conflict of interest in this publication.
If the events of the first half of 2020 have taught us nothing else, it is that we are in the midst of an era defined by
It is in this era that students are persevering to obtain an education, and their instructors are persevering to provide it to them. If the grandparents of yesteryear spoke hyperbolically of their “walk to school that was uphill both ways,” today’s students certainly will have a similar tale to tell – but one devoid of hyperbole – of the uphill battle they and all the members of their schools and universities fought to keep educational goals on track in a world that was in a constant state of flux.
In this uncertain world, students need creative thinking more than ever before - and it is this particularly salient life skill that is lacking in our educational system. Despite the fact that creativity has been named one of the top-10 skills necessary for success in the twenty-first century [1], the current education system in the developed world stifles creativity through its focus on convergent thinking and standardized testing [2, 3, 4]. As this position is already widely supported, this chapter focuses on making a case for teaching creatively and creativity in higher education, with a specific focus on a significant barrier that stands in the way of enhanced levels of creative education. We maintain that a stigma exists in association with creativity, and that until this stigma is called out and addressed, higher education will continue to fall short of providing this essential twenty-first century skill to its students.
The perception of creativity by laypeople is explored in this chapter by way of the Adaptor-Innovator theory of creativity, and the implicit and explicit theories of creativity. The stigma toward creativity in education is examined through the lens of the social psychology of the construction of stigma and is supported through seminal and current research in the field of creativity studies. The paper will conclude with proposed antidotes to address and fight this stigma.
There is a dearth of research on
The focus on creativity in education in the Western hemisphere became a key area of concern following the successful launch of
Creativity field experts, including Csikszenthihalyi, Guilford, Parnes, and Treffinger, influenced the shift in formal education from “knowledge acquisition” [6] to teaching children how to “deal with ambiguous problems, coping with the fast-changing world and facing an uncertain future” ([5], p. 166) [7].
But what
In 1953, Stein defined
In this same seminal piece, Stein also explores the important role that culture plays in the fostering and acceptance of creativity - a point that resonates with the current topic of acceptance of creativity within higher education: “Attention must also be directed,” Stein states, “to the broader aspects of education. For example, does the culture tolerate deviation from the traditional, the status quo, or does it insist upon conformity, whether in politics, science, or at school? Does the culture permit the individual to seek new experiences on his own, or do the bearers of culture (parents, teachers, and so on) ‘spoon-feed’ the young so that they constantly find ready-made solutions available to them as they come upon a situation that is lacking in closure ([9], p. 319)?” It is this critical connection between
There is an interesting pattern that arises in subsequent definitions of creativity. Creativity is specifically referred to as an
In Bloom’s revised taxonomy,
A recent study by van Broekhoven, Cropley, and Seegers explored the nature of creativity in students in the arts versus those in science, technology, engineering, and mathematics (STEM) courses. They surveyed 2,277 German university students and found that high openness, high Creative Self-Efficacy, and strong proficiency in divergent thinking are “general prerequisites for creativity” across
All students - in art, science, technology, engineering, and mathematics - not only have the potential to be creative, but must have this innate predisposition enhanced to ensure success in their own disciplines, and prepare them for success in their careers and lives beyond university.
The role of higher education is to prepare students for future success. Today’s world can be best described by an acronym used in pedagogy by the U.S. Army War College since the late 1980s:
To highlight the nature of our rapidly evolving world, the 2018 World Economic Forum charts the skills on the rise and on the decline in the workplace. By 2022, the top 10 skills that will be in demand include the following [1]:
Analytical thinking and innovation
Active learning and learning strategies
Creativity, originality, and initiative
Technology design and programming
Critical thinking and analysis
Complex problem-solving
Leadership and social influence
Emotional intelligence
Reasoning, problem-solving, and ideation
Systems analysis and evaluation
This list highlights the importance of creativity. Not only is it explicitly referenced as the third item on this list, but the skills inherent to creativity and creative problem-solving (i.e. analytical thinking, innovation, active learning, critical thinking, complex problem-solving, leadership, social influence, emotional intelligence, reasoning, ideation) appear throughout the entire list. Creativity is the driving force of innovation in our VUCA world. Our educational system, however, seems to be woefully lagging behind in fostering the creativity-relevant skills so necessary for success in today’s workplace.
Despite creativity’s necessary place in education, it is missing from curricula and practice. Moreover, a strange series of stereotypes and misconceptions can be spotted when the word
In the late 1970s, Kirton put forth a theory and an assessment by which one’s creative
Highly adaptive people (“Adaptors”) are primarily concerned with making improvements to ideas or processes that fit within the confines of the parameters already set in place within their organizations. They are likely to try to solve rather than seek problems. They tend to challenge rules cautiously, and usually only when backed by others. Highly innovative people (“Innovators”), on the other hand, are concerned with making improvements to ideas or processes by removing those ideas or processes from the confines of the previously established organizational conventions, and then proposing solutions that completely reconceptualize the idea. They tend to discover both problems and unique solutions, and often challenge rules at the expense of previously held traditions [23].
According to Kirton, in traditional workplaces, Adaptors’ solutions to problems are more readily accepted as they already fit within a familiar framework, whereas Innovators’ solutions face more opposition, as they seem to “come out of left field,” and thus tend to be seen as more
From the Adaption-Innovation Theory stems a body of research aimed at exploring laypersons’ perceptions toward Adaptors and Innovators within work environments, particularly as those attitudes pertain to creative problem solving. This line of research has illuminated the phenomenon that laypersons have a bias toward perceiving an “innovative” person as being more creative than an “adaptive” person. Thus, this bias reveals how
Implicit theories, in general terms, are a result of the constellation of observations gathered by laypersons as driven by their own perception of the world. Explicit theories, by contrast, are a result of empirical study and scientific observation. Thus, implicit theories of creativity are those influenced by how “the public” view creativity. Explicit theories of creativity are those driven by academic research. Research patterns indicate that implicit theories of creativity – laypeople’s idea of what a “creative person” looks like – are very much in keeping with the description of the Innovator as outlined by Kirton [24]. The findings from a series of studies across a range of cultures generally support this claim.
A 2000 study presented 188 American participants with two different lists of characteristics, labeled “Person A” (whose list was populated with Adaptor traits) and “Person B” (whose list was populated with Innovator traits; the Person A and Person B lists were randomized to prevent an order effect; that is to say, in some cases Person A reflected the innovative qualities and Person B the adaptive characteristics). Survey respondents were asked to rate the creativity of both persons on a 10-point scale ranging from 1 (not at all creative) to 10 (exceptionally creative). Results revealed that the participants judged the “person” with Innovator traits as being significantly more creative than the “person” with the Adaptor traits. Research participants also completed the KAI and it was found that those with an innovative preference showed an even stronger bias in judging the Innovative style as being more creative [25, 26].
In an ensuing 2003 study, 128 Argentinian participants took a similar measure, in which a person is described with Innovator traits and another person is described with Adaptor traits, and then were asked to supply words that they associated with
A 2014 study compared 139 laypeople from the U.S. and 384 laypeople from the main ethnic groups in Singapore (defined by the researchers as Chinese, Indian, and Malay). Using the same measure described previously, results indicated that Kirton’s Innovators were rated as being more creative than Adaptors, and words common across both groups associated with creativity were “think outside the box,” “new,” “innovative,” “unusual,” and “different” ([28], p. 227).
A study with contradictory findings still sheds light on the implicit and explicit theories of creativity. In a study of 201 Saudi Arabian laypeople, participants used the same instrument - they were presented with Kirton’s description of the Adaptor as one persona and the Innovator as a second persona and were asked to rate each style with respect to creativity level, and then provide words they associated with
In an effort to examine college and university students’ implicit perceptions of creativity, a pilot study was conducted in which 93 undergraduates at a northeastern American liberal arts college were asked “what words do you associate with creativity?” The top five words included
Finally, research conducted by Mueller, Melwani, and Goncalo provide important insights. In an article entitled “The Bias Against Creativity: Why People Desire but Reject Creative Ideas,” the results from two studies suggest that when faced with uncertainty, people are likely to harbor an implicit bias against creativity and also judge creative ideas more harshly. Additionally, when unoriginal or “more practical” solutions are readily available, people tend to be less accepting of creative ideas [31]. In a later book,
From the research explored above, we can make the following assertions. First, Adaptors and Innovators are
Therefore, when laypeople are asked about their attitudes toward
The hypothesis set forth in this chapter is that fostering creativity as a teaching practice is not implemented with greater intentionality in higher education because a stigma exists toward creativity in the classroom. This stigma is based on creativity’s association with disruptive behavior. To examine this hypothesis further, let us define and explore the construct of social stigma.
Since Erving Goffman first explained stigma as the process by which members of society reduce a person in their minds based on some perceived discrediting aspect [33], much effort has been put forth toward the advancement of a deeper understanding of not just what sigma is, but how it is formed. Consider these two definitions of stigma: Stigma is “a characteristic of persons that is contrary to a norm of a social unit” ([34], p. 80) and “stigmatized individuals possess (or are believed to possess) some attribute, or characteristic, that conveys a social identity that is devalued in a particular social context” ([35], p. 505) [36].
Stangor and Crandall [37] developed a theoretical model that helps explain how stigma develops, involving three major components: (1) function, (2) perception, and (3) social sharing (Figure 1). While this and related frameworks are usually applied to stigma research in the field of health communication and in sociological arenas, like mental illness stigma [38], AIDS stigma [39], and homelessness stigma [40], this framework is also relevant to the implementation of creativity in higher education.
The role of threat, perceptual distortions, and societal sharing in the development of stigma. Source: Stangor and Crandall ([
This chapter will focus on the first stage of stigma formation in Stangor and Crandall’s model: The initial perception of a
We have established the case by which
In the introduction to
When Torrance and Safter opine that there are not enough “great teachers” in the world, they identify “great teachers” as those who have the following characteristics ([43], p. 1):
Great teachers perform miracles.
They inspire their students… to creative and independent thinking and action which may at times get out of hand.
They are continually in danger of “crucifixion.”
The latter two statements, in which a creatively-led classroom may occasionally get out of hand, and in which the instructor is in danger of literal (or, as is more likely the case in contemporary experience, figurative) crucifixion, speak to stigmatization of creatively-led classrooms as disruptive, and those who lead those classrooms as disruptors deserving of punishment.
A review of seminal and contemporary literature concerning perceptions of creativity - in terms of teaching
In a 2005 study of 36 elementary school teachers, Aljughaiman and Mowrer-Reynolds conducted in-depth interviews with educators that explored the teachers’ attitudes toward creativity, definitions of creativity, and perceptions of creative students. Results revealed that teachers frequently misconstrue what it means to be a
In his chapter entitled “Creativity in the Classroom: The Dark Side” in the book
shakes the foundations of the received classroom order,
brings uncertainty for pupils (and parents),
questions the value of laboriously acquired knowledge and skills,
threatens loss of status and authority for teachers, and
weakens teachers’ self-image ([45], p. 304).
The stigma toward creativity again becomes evident in this list - namely, that creativity is a symbolic threat, and that the threat is in the form of
Marquis and Henderson [46] conducted a study across eight universities in Ontario to determine how instructors perceive and implement the teaching and learning of creativity. The study cites a common theme found within literature on creativity in higher education - that creativity is heralded as an important skill (in Marquis and Henderson’s article, by a 2012 report by the provincial government), but little to no data exist which address how this need is mobilized in the university environment.
One of the factors explored in this study was the influence of instructors’ disciplinary identities on their perception of creativity and its pedagogical modalities. Disciplinary influence on the conceptualization of creativity include the argument of domain specificity (that true creativity within a given field can only be assessed by experts within that field), some may perceive creativity as more pertinent to some fields over others, and finally, that creativity is often affected by the aforementioned “art bias”, through which creativity is fused in its scope with the arts, specifically.
The instrument used in Marquis and Henderson’s study was a digital survey instrument in which the approximately 613 respondents were asked to provide definitions of creativity and to answer questions about the importance of creativity in their disciplines and their strategies for helping students develop their creative abilities. Several interesting findings emerged from this study, chief of which is the definitions of creativity provided by the participants and the overall value placed on creativity.
Definitions were characterized by themes common to the literature including
While both the overall importance of creativity and the responsibility to foster students’ creativity were nearly universally rated as “important,” some respondents from the STEM fields indicated that they had a difficult time envisioning the role of creativity within their fields, basing these statements on the assumption that creativity was about developing something entirely new, a point that speaks to the bias toward innovators over adaptors in the research previously described. Marquis and Henderson also found that
Banaji, Cranmer, and Perrotta [47] conducted interviews of 81 educational stakeholders within European schools in an endeavor to uncover the barriers toward creativity implementation within the school system. They provide further support for this hypothesis in describing how the notion of “disciplinarian classroom environments” is passed on through generations of educational trainers to trainees, promoting an environment in which nonconformity is punished. Banaji, Cranmer, and Perrotta provide further evidence in stating that “some teachers’ fear of losing control of the discipline in classes – linked to a lack of confidence in their own classroom management skills – discourages active learning approaches more widely than attempts to nurture creativity” ([47], p. 10). That the perceived disorder of a classroom is linked with teachers’ confidence in their own classroom management abilities is a salient point that is further examined in the next section.
In the literature about social stigma as applied to the field of health communication, top strategies implemented in the fight against social stigma include “education and teaching,” and “normalizing” (e.g. [48, 49]). Therefore, it is logical to believe that we might reduce the symbolic threat-based stigma of the perception of creativity in the classroom as disruptive through these same means - creativity training and creativity normalization.
In their 2018 meta-analysis of 53 contemporary studies examining teachers’ beliefs about creativity and its nature, authors Bereczki and Kárpáti [3] concluded that teachers’ beliefs toward creativity-fostering practices would be dramatically improved through gaining professional competency in teaching for creativity. Thus, one might extrapolate that the importance of implementation of creativity training among educators in the college and university setting cannot be ignored.
Consider Sheridan College in Ontario, Canada as an example. Around 2012, Sheridan College, formerly known as the Sheridan College Institute of Technology and Learning, set the goal of becoming a fully creative campus. Sheridan operationalized this goal by infusing creativity into their discipline-based courses, as well as offering courses fully centered on the subject of creativity. Sheridan also created a series of intensive professional development workshops on building creative thinking and creative problem solving into course learning outcomes, Creative Problem Solving, small group facilitation, and creativity training. Finally, Sheridan sought to infuse creative thinking and creative problem solving strategies and tactics into the college’s day-to-day operations. These efforts have seen great success. Over 3,000 students have enrolled in a general elective course called “Creative Thinking: Theory and Practice.” Well over 6,500 students have taken at least one of the five courses in a 5-course undergraduate certificate in creativity, with 200 students having completed the full certificate. And more than 300 faculty and administrators have taken part in the creativity professional development workshops [50]. Sheridan College serves as an exemplary case study in internalizing and operationalizing creativity at an institutional level. For two more case studies on universities that have successfully internalized creativity at this level, see Universidad Autónoma de Bucaramanga, Colombia, the first fully creative campus in Latin America, and the International Center for Studies in Creativity at SUNY Buffalo State [51].
As stated in Puccio and Lohiser [51], “There should be creativity courses, creativity content, and creativity professors at every university and college in the world” ([51], p. 26). The increase in competence in teaching creatively would thus not only mechanize the implementation of creativity in the classroom, but would also serve to increase instructors’ confidence in their own abilities to foster creativity in an intentional manner, which in turn will likely reduce the stigma of creativity resulting in disorder and disruption.
It is our belief that the very act of training instructors in how to efficiently and effectively mobilize creativity as a pedagogical tool will initiate a normalization process. A red thread that runs through the courses at the Creativity and Change Leadership Department (formerly the International Center for Studies in Creativity) at SUNY Buffalo State is that its students should embrace creativity in every facet of their lives. Graduates should be so comfortable with the creative process that it becomes a way of life, rather than simply serving as a tool one produces from a toolbox and then files neatly away when a task is completed. Anecdotal evidence collected through interactions with peers in the program, and even the friends, family members, and colleagues of those peers suggests that the training in creativity functions as a deeply rooted normalization process that spreads, social-contagion style, through daily lexicon and routine behavior. Moreover, recent research has shown that the impact of the creativity curriculum taught at SUNY Buffalo State significantly improves creative attitudes [52] and shows long-lasting effects on divergent-thinking abilities [14]. If critical creativity components, including the Thinking Skills Model of Creative Problem Solving [53], The FourSight Model [54], and the Torrance Incubation Model of teaching [43], can be trained and taught to educators as prolifically as possible, it is quite likely that creativity will become a more normalized phenomenon within education, and thus will gradually be freed from stigma.
Creativity, as suggested by the scholars cited thus far, can be considered
This philosophy of embracing creativity as a lifestyle can be analyzed through the lens of the Theory of Reasoned Action [55] and can be used as a model through which to enact the societal change necessary to overcome the stigma toward creativity in higher education.
The Theory of Reasoned Action, developed by Martin Fishbein and Icek Ajzen in 1967, charts the process by which attitudes inform beliefs, which influence individuals’ intent to act, which then serve to rejuvenate the cycle through informed knowledge [55]. Figure 2 shows an adapted model of this theory that has been structured by the authors of this chapter to serve as a lens through which to mobilize a deliberate approach toward combating stigma toward creativity in higher education.
Theory of reasoned action adapted to the intention to adopt creativity in higher education.
This modified model of the Theory of Reasoned Action shows that individuals’ beliefs about the
Fostering a positive attitude toward creativity in higher education is paramount to its successful application. Creativity, in part, can be considered an attitude, or mindset. Fostering deeply-held positive beliefs toward creativity is similarly critical. Quintessentially, creativity also is a belief system, and ultimately, creativity is the product of a culminated set of behaviors, potentially a lifestyle of cultivated actions. These behaviors include seeking opportunities to constructively evolve through Polarity Management [56], which is to say, maintaining the status quo where helpful and, more relevant to the current situation, disrupting the status quo where necessary and seeking opportunities to lead others
If more instructors were to increase their intention to ultimately embrace creativity, this intention will hopefully lead to action, which will in turn provide feedback on a broader normative belief system and subjective societal norm concerning creativity in academia. For every individual who disrupts the status quo of what is arguably a lack of deliberately creative education tactics within higher education, those individuals would contribute positively to developing normative societal and subjective beliefs about creativity.
As stated in the opening of this chapter, the topic of stigma toward creativity explored as it relates to education in a general sense is meant to serve as a springboard for a deeper dive into the realm of higher education. While stigma toward creativity is already documented, few studies exist on the
A widely accepted tenet of the relationship among these constructs of attitude, behavior, communication, and stigma [58] suggests that stereotypes are born out of natural human habits toward cognitive processing. The reduction of one’s cognitive load through categorization of information can corrupt into binary absolutes and laws (e.g. “all people from X group are alike in this particular way”). These cognitions travel, as it were, to the heart where they stimulate emotional responses (e.g. “That person is from X group toward which I have a negative association, and so I fear him”). The emotion then travels outward to the limbs, where the emotion is made manifest into behavior, becoming discrimination (e.g. “I will not engage with him based on my fear”).
The key, then, to changing individuals’ behavior - to reducing stigma-led discrimination toward creativity as a critical educational subject and critical educational method - lies in changing hearts and minds. Minds must be changed through training and education, and the subsequent normalization might just change hearts. Creativity is a force for innovation. If we do not promote creative thinking in our educational practices, if we do not teach
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Integrity - We are consistent and dependable, always striving for precision and accuracy in the true spirit of science.
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\n\nIntechOpen is a dynamic, vibrant company, where exceptional people are achieving great things. We offer a creative, dedicated, committed, and passionate environment but never lose sight of the fact that science and discovery is exciting and rewarding. We constantly strive to ensure that members of our community can work, travel, meet world-renowned researchers and grow their own career and develop their own experiences.
\n\nIf this sounds like a place that you would like to work, whether you are at the beginning of your career or are an experienced professional, we invite you to drop us a line and tell us why you could be the right person for IntechOpen.
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The freezing pattern of the liquid melt decides the feeding of the mould which is instrumental in producing a complete and compact casting. For pure metals and even in case of alloys with a narrow freezing range a well defined solid–liquid macro-interface exists. Here feeding of the solidifying casting is the easiest, by the common lowering of the liquid metal surface in the mould. However, in many instances, a well defined interface is not witnessed. The solid–liquid interface could be discrete and not continuous. Here process of feeding the solidification sites that witness considerable shrinkages, may become complicated. 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It starts with an introduction into the wide bandgap (WBG) materials and the properties that make them potential candidates to enable the development of harsh environment microsystems. The future commercial success of WBG microsystems depends mainly on the availability of high-quality materials, well-established microfabrication processes, and economic viability. In such aspects SiC platform, in relation to other WBG materials, provides a clear and competitive advantage. The reasons for this will be detailed. Furthermore, the current status of the SiC thin film and bulk material technologies will also be discussed. 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Nitrogen-bearing stainless steel (HNSS) is a new corrosion-resistant alloy class exhibiting better tribological properties. High-pressure and powder metallurgy techniques were developed for the fabrication of HNSS. Solid-state routes allow nitrogen introduction through thermochemical, implantation, or plasma surface treatments. High-temperature gas nitriding (HTGN), carried out in an N2 atmosphere in the 1000°C range, allows N uptake, obtaining thick, ~0.5–1.0 wt.% N austenitic cases. HTGN is different from conventional nitriding, performed in the 500°C range, where intense CrxNy precipitation occurs, impairing the corrosion resistance. Low-temperature plasma nitriding (LTPN) introduces more N in solution, and colossal supersaturated expanded phases (~45 at.%N) are formed. N supersaturation and compressive stresses increase the hardness of the surface layer to 10–14 GPa. Ferritic, martensitic, duplex, and precipitation-hardened stainless steels can be surface-treated by LTPN, obtaining expanded ferrite and martensite. However, single LTPN stainless steel may prematurely fail when submitted to high loading, as the thin and hard expanded layers collapse due to lack of load-bearing capacity. Duplex-nitriding treatment (HTGN + LTPN) results in a thick nitrogen-rich hardened austenite substrate layer, granting mechanical support and adhesion to the expanded austenite layer.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"André Paulo Tschiptschin and Carlos Eduardo Pinedo"},{id:"81579",title:"Welding Based Additive Manufacturing: Fundamentals",slug:"welding-based-additive-manufacturing-fundamentals",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.104768",abstract:"Additive Manufacturing (AM) has drawn abundant attention over the past decades in the manufacturing and fabrication industries, especially to make part models and prototypes. This chapter introduces a potential welding based AM process called Wire Arc Additive Manufacturing (WAAM) for the fabrication of near-net shaped metal components including stainless steel components. To start with traditional AM processes, various fundamental traditional AM for the fabrication of components have been presented. Wire Arc Additive Manufacturing (WAAM) has been explained with its variants, synonyms, different welding processes to suit WAAM particularly to weld stainless steel metal; primary process selections for working with WAAM, important metals, and alloys that could be used in WAAM have been elaborated. A case study for WAAM fabrication of AISI 316 L stainless steel plate is included to introduce the fabrication of metal components using WAAM. Further, the most common defects which possibly play a vital role in WAAM components fabrication and a few of the future challenges regarding WAAM development are discussed. Fundamental information covered in this chapter could be more beneficial to beginners for the understanding of WAAM process generally including stainless steel component fabrication in a lucid tactic.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Maruthasalam Sowrirajan, Selvaraj Vijayan and Munusamy Arulraj"},{id:"80664",title:"Dependence of Corrosion Resistance of Austenitic Chromium-Nickel Steels on the Magnetic State of Austenite",slug:"dependence-of-corrosion-resistance-of-austenitic-chromium-nickel-steels-on-the-magnetic-state-of-aus",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.102388",abstract:"Corrosive behavior of austenitic chromium-nickel steels from the magnetic state (parameter χ0) of austenite, pre-formed to interact with aggressive media are research. Correlation between the rate K of pitting corrosion and the specific magnetic susceptibility χ0 of austenite was experimentally established. It is experimentally established that the corrosion resistance of austenitic steels AISI304, 08Cr18Ni10, AISI 321, 08Cr18Ni10Тi (containing a low amount of δ-ferrite ∼0.005…0.5%) depends on the magnetic state of austenite: the corrosion rate of steel decreases with increases χ0 austenite. The tendency of change in the corrosion rate of austenitic alloy with a high nickel content 06Crh28NiMoCuTi (not contain δ-ferrite) has the opposite character: with increasing χ0, the corrosion rate of the alloy increases is revealed. For austenitic chromium-nickel steels, the corrosion rates of the individual (austenite (A), δ-ferrite (F), strain-induced α′-martensite (M)) and total (A + F, A + M and A + F + M) phases are determined. It is proposed to predict corrosion according to the specific magnetic susceptibility χ0 of austenite and the amount δ-ferrite.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Gennadii Snizhnoi"},{id:"80199",title:"The Evaluation of the Comparative Corrosion Behaviour of Conventional and Low-Nickel Austenitic Stainless Steel: Hercules™ Alloy",slug:"the-evaluation-of-the-comparative-corrosion-behaviour-of-conventional-and-low-nickel-austenitic-stai",totalDownloads:55,totalDimensionsCites:0,doi:"10.5772/intechopen.102381",abstract:"Austenitic stainless steels require approximately 8% Ni to maintain austenitic microstructure at room temperature for alloys such as 304 stainless steel (304SS). Ni contributes approximately 60% of the total material cost and its price fluctuates, making the cost of austenitic stainless steel unpredictable. The use of low-nickel austenitic stainless steels as a substitute has been considered in order to remedy costs associated with Ni price fluctuations. Alloying elements such as Mn and N have been considered, however they have been found to reduce corrosion resistance. A new alloy namely Hercules™ has been developed with reduced Ni content (1.8–2% Ni). This chapter presents a comparative study of the corrosion behavior of Hercules™ and 304SS in different solutions. The alloys were evaluated using cyclic polarisation technique and immersion tests. The results demonstrated that the corrosion resistance of Hercules™ is comparable to that of 304SS. This presents the alloys as potential industrial substitutes of each other.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Duduzile Nkomo and Nomsombuluko Masia"},{id:"80346",title:"Nitrogen Supersaturation of AISI316 Base Stainless Steels at 673 K and 623 K for Hardening and Microstructure Control",slug:"nitrogen-supersaturation-of-aisi316-base-stainless-steels-at-673-k-and-623-k-for-hardening-and-micro",totalDownloads:59,totalDimensionsCites:1,doi:"10.5772/intechopen.102387",abstract:"The high-density plasma nitriding at 673 K and 623 K was employed to make 10% of nitrogen supersaturation on AISI316 base austenitic stainless steels. The processing parameters and nitrogen-hydrogen gas flow ratio were optimized to increase the yield of N2+ ion and NH-radical for efficient nitriding. The nitrided AISI316 specimens were prepared for multidimensional analysis to describe the fundamental features of low-temperature plasma nitriding. First, macroscopic evaluation revealed that nitrogen supersaturation induced the γ-lattice expansion and the higher nitrogen content than 4% of mass in depth. The mesoscopic analysis describes the holding temperature and initial grain-size effects on the microstructure changes. Plastic straining, grain-size refinement, and nitrogen zone-boundary diffusion processes advance with nitrogen supersaturation to drive the inner nitriding behavior. The microscopic analysis explains the microstructure refinement, the two-phase structuring, and the microstructure modification. Through this multi-dimensional analysis, the essential characteristics of the low-temperature plasma nitriding of 316 austenitic stainless steels were precisely understood to extend the engineering treatise on the bulk nitrogen stainless steels for surface modification and treatment of stainless steels by nitriding. This plasma nitriding was applied to strengthen and harden the AISI316 wire surfaces toward its application on surgery wires.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Tatsuhiko Aizawa, Tomomi Shiratori, Tomoaki Yoshino, Yohei Suzuki and Takafumi Komatsu"},{id:"79904",title:"Corrosion Resistance, Evaluation Methods, and Surface Treatments of Stainless Steels",slug:"corrosion-resistance-evaluation-methods-and-surface-treatments-of-stainless-steels",totalDownloads:106,totalDimensionsCites:1,doi:"10.5772/intechopen.101430",abstract:"Stainless steels are widely recognized and find applications in many engineering industries and companies due to their excellent properties including high resistance to corrosion as a result of their minimum 10.5% chromium content, exceptional strength and durability, temperature resistance, high recyclability, and easy formability. In the present book chapter, the basic concepts of stainless steel including its applications, classifications, and corrosion properties will first be discussed. Thereafter, their corrosion behaviour will then be explained. The various methods by which the corrosion resistance behaviour can be significantly improved including surface treatments such as coatings/electrodepositions, alloying, mechanical treatment, and others will be discussed in detail.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Temitope Olumide Olugbade"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",isOpenForSubmission:!0,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",isOpenForSubmission:!0,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",isOpenForSubmission:!0,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:27,paginationItems:[{id:"83092",title:"Novel Composites for Bone Tissue Engineering",doi:"10.5772/intechopen.106255",signatures:"Pugalanthipandian Sankaralingam, Poornimadevi Sakthivel and Vijayakumar Chinnaswamy Thangavel",slug:"novel-composites-for-bone-tissue-engineering",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:0,authors:null,book:{title:"Biomimetics - Bridging the Gap",coverURL:"https://cdn.intechopen.com/books/images_new/11453.jpg",subseries:{id:"8",title:"Bioinspired Technology and Biomechanics"}}},{id:"82800",title:"Repurposing Drugs as Potential Therapeutics for the SARS-Cov-2 Viral Infection: Automatizing a Blind Molecular Docking High-throughput Pipeline",doi:"10.5772/intechopen.105792",signatures:"Aldo Herrera-Rodulfo, Mariana Andrade-Medina and Mauricio Carrillo-Tripp",slug:"repurposing-drugs-as-potential-therapeutics-for-the-sars-cov-2-viral-infection-automatizing-a-blind-",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82582",title:"Protecting Bioelectric Signals from Electromagnetic Interference in a Wireless World",doi:"10.5772/intechopen.105951",signatures:"David Marcarian",slug:"protecting-bioelectric-signals-from-electromagnetic-interference-in-a-wireless-world",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"82586",title:"Fundamentals of Molecular Docking and Comparative Analysis of Protein–Small-Molecule Docking Approaches",doi:"10.5772/intechopen.105815",signatures:"Maden Sefika Feyza, Sezer Selin and Acuner Saliha Ece",slug:"fundamentals-of-molecular-docking-and-comparative-analysis-of-protein-small-molecule-docking-approac",totalDownloads:27,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Molecular Docking - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11451.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. 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Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}}]}},subseries:{item:{id:"22",type:"subseries",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11418,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. 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