\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"},{slug:"intechopen-s-chapter-awarded-the-guenther-von-pannewitz-preis-2020-20200715",title:"IntechOpen's Chapter Awarded the Günther-von-Pannewitz-Preis 2020"},{slug:"suf-and-intechopen-announce-collaboration-20200331",title:"SUF and IntechOpen Announce Collaboration"}]},book:{item:{type:"book",id:"1770",leadTitle:null,fullTitle:"Gel Electrophoresis - Principles and Basics",title:"Gel Electrophoresis",subtitle:"Principles and Basics",reviewType:"peer-reviewed",abstract:"Most will agree that gel electrophoresis is one of the basic pillars of molecular biology. This coined terminology covers a myriad of gel-based separation approaches that rely mainly on fractionating biomolecules under electrophoretic current based mainly on the molecular weight. In this book, the authors try to present simplified fundamentals of gel-based separation together with exemplarily applications of this versatile technique. We try to keep the contents of the book crisp and comprehensive, and hope that it will receive overwhelming interest and deliver benefits and valuable information to the readers.",isbn:null,printIsbn:"978-953-51-0458-2",pdfIsbn:"978-953-51-4309-3",doi:"10.5772/2205",price:139,priceEur:155,priceUsd:179,slug:"gel-electrophoresis-principles-and-basics",numberOfPages:378,isOpenForSubmission:!1,isInWos:1,hash:"279701f6c802cf02deef45103e0611ff",bookSignature:"Sameh Magdeldin",publishedDate:"April 4th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",numberOfDownloads:227344,numberOfWosCitations:103,numberOfCrossrefCitations:39,numberOfDimensionsCitations:118,hasAltmetrics:1,numberOfTotalCitations:260,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 26th 2011",dateEndSecondStepPublish:"June 23rd 2011",dateEndThirdStepPublish:"October 28th 2011",dateEndFourthStepPublish:"November 27th 2011",dateEndFifthStepPublish:"March 26th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin",profilePictureURL:"https://mts.intechopen.com/storage/users/123648/images/475_n.jpg",biography:"Sameh Magdeldin is senior researcher in the Medical School,\nNiigata University, Japan, and academic associate professor in\nthe Physiology Department, Suez Canal University (SCU), Egypt.\nHe received his M.V.Sc. and Ph.D. in Physiology and his second\nPh.D. in Proteomics in July 2012. He has expertise in shotgun proteomics analysis, reversed-phase chromatography and label-free comparative proteomics\napproaches. Dr. Magdeldin has published outstanding articles on aquaporin research using proteomics technology. He also created the outstanding “All and\nNone” methodology for analyzing large-throughput proteomics data published\nin a highly respected proteomics journal. He currently serves as a guest editor,\nassociate editor and peer reviewer for several international journals. Dr. Magdeldin received several grants and awards, such as the national encouraging prize,\n8th HUPO congress young investigator award, JSN award, grant-in-aid for young\nscientists and young researcher overseas grant from the Japan Society for the\nPromotion of Science (JSPS).",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"Niigata University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"410",title:"Biotechnology",slug:"biochemistry-genetics-and-molecular-biology-microbiology-biotechnology"}],chapters:[{id:"35087",title:"Introduction to Agarose and Polyacrylamide Gel Electrophoresis Matrices with Respect to Their Detection Sensitivities",doi:"10.5772/38573",slug:"introduction-to-agarose-and-polyacrylamide-gel-electrophoresis-matrices-with-respect-to-their-detect",totalDownloads:31980,totalCrossrefCites:10,totalDimensionsCites:17,signatures:"Patricia Barril and Silvia Nates",downloadPdfUrl:"/chapter/pdf-download/35087",previewPdfUrl:"/chapter/pdf-preview/35087",authors:[{id:"118087",title:"Dr.",name:"Silvia",surname:"Nates",slug:"silvia-nates",fullName:"Silvia Nates"},{id:"118134",title:"Dr.",name:"Patricia",surname:"Barril",slug:"patricia-barril",fullName:"Patricia Barril"}],corrections:null},{id:"35088",title:"Gel-Electrophoresis and Its Applications",doi:"10.5772/38479",slug:"gel-electrophoresis-and-its-applications",totalDownloads:17184,totalCrossrefCites:2,totalDimensionsCites:4,signatures:"Pulimamidi Rabindra Reddy and Nomula Raju",downloadPdfUrl:"/chapter/pdf-download/35088",previewPdfUrl:"/chapter/pdf-preview/35088",authors:[{id:"117476",title:"Prof.",name:"Rabindra",surname:"Reddy",slug:"rabindra-reddy",fullName:"Rabindra Reddy"},{id:"118369",title:"Mr.",name:"Raju",surname:"Nomula",slug:"raju-nomula",fullName:"Raju Nomula"}],corrections:null},{id:"35089",title:"Principles of Nucleic Acid Separation by Agarose Gel Electrophoresis",doi:"10.5772/38654",slug:"principles-of-nucleic-acid-separation-by-agarose-gel-electrophoresis",totalDownloads:35382,totalCrossrefCites:4,totalDimensionsCites:10,signatures:"Muhittin Yılmaz, Cem Ozic and İlhami Gok",downloadPdfUrl:"/chapter/pdf-download/35089",previewPdfUrl:"/chapter/pdf-preview/35089",authors:[{id:"118546",title:"Dr.",name:"Muhitdin",surname:"Yilmaz",slug:"muhitdin-yilmaz",fullName:"Muhitdin Yilmaz"},{id:"143191",title:"Dr.",name:"Cem",surname:"Ozic",slug:"cem-ozic",fullName:"Cem Ozic"},{id:"143193",title:"PhD.",name:"İlhami",surname:"Gok",slug:"ilhami-gok",fullName:"İlhami Gok"}],corrections:null},{id:"35090",title:"Discriminatory Power of Agarose Gel Electrophoresis in DNA Fragments Analysis",doi:"10.5772/36891",slug:"discriminatory-power-of-agarose-gel-electrophoresis-in-dna-fragment-analysis",totalDownloads:31746,totalCrossrefCites:2,totalDimensionsCites:2,signatures:"Seow Ven Lee and Abdul Rani Bahaman",downloadPdfUrl:"/chapter/pdf-download/35090",previewPdfUrl:"/chapter/pdf-preview/35090",authors:[{id:"110308",title:"Dr.",name:"Seow Ven",surname:"Lee",slug:"seow-ven-lee",fullName:"Seow Ven Lee"}],corrections:null},{id:"35091",title:"Gel Electrophoresis of Proteins",doi:"10.5772/37514",slug:"gel-electrophoresis-of-proteins",totalDownloads:10408,totalCrossrefCites:1,totalDimensionsCites:2,signatures:"Laura García-Descalzo, Eva García-López, Alberto Alcázar, Fernando Baquero and Cristina Cid",downloadPdfUrl:"/chapter/pdf-download/35091",previewPdfUrl:"/chapter/pdf-preview/35091",authors:[{id:"113044",title:"Dr.",name:"Cristina",surname:"Cid",slug:"cristina-cid",fullName:"Cristina Cid"},{id:"138425",title:"Dr.",name:"Fernando",surname:"Baquero",slug:"fernando-baquero",fullName:"Fernando Baquero"},{id:"138426",title:"Dr.",name:"Laura",surname:"Garcia-Descalzo",slug:"laura-garcia-descalzo",fullName:"Laura Garcia-Descalzo"},{id:"138427",title:"Dr.",name:"Eva",surname:"Garcia-Lopez",slug:"eva-garcia-lopez",fullName:"Eva Garcia-Lopez"},{id:"138428",title:"Dr.",name:"Alberto",surname:"Alcazar",slug:"alberto-alcazar",fullName:"Alberto Alcazar"}],corrections:null},{id:"35092",title:"Gel Electrophoresis of Protein - From Basic Science to Practical Approach",doi:"10.5772/38062",slug:"gel-electrophoresis-of-protein-from-basic-science-to-practical-approach",totalDownloads:6268,totalCrossrefCites:0,totalDimensionsCites:1,signatures:"Gholamreza Kavoosi and Susan K. 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Derived from the Greek word, ἐμβολισμός, this term most literally means “interposition.” Yet, regardless of how benign this etymological derivation may appear, the clinical context is quite the opposite—a symbol of much dreaded morbidity and mortality. Whether the embolus consists of a blood clot, a fat globule, a bubble of gas, amniotic fluid, or even an iatrogenic or traumatic foreign body, the unfavorable connotations persist even if the patient has few or no associated symptoms and requires no intervention.The primary goal of this book is to provide the reader with an overview of the most common types of embolic phenomena encountered in clinical practice, including some of the key related diagnostic and therapeutic considerations. 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The vocal folds, also known as vocal cords, extend through the laryngeal cavity bilaterally and are primarily responsible for voice production. The thyroarytenoid muscle, deep lamina propria, intermediate lamina propria, superficial lamina propria, and squamous epithelium comprise the vocal folds [1, 2, 3]. The superficial lamina propria, which is also called Reinke’s space, consists of loose fibrous or elastic components and provides a gelatinous surface for vocal folds to vibrate upon. The deep and superficial lamina propria forms the vocal ligament. Madruga et al. demonstrated that type I collagen is abundant in the superficial lamina propria which forms a narrow band. The intermediate lamina propria essentially contains type III collagen, and the deep lamina propria is rich from both type I and type III collagen [4].
\nIn a study of Chandramouli et al., nonneoplastic lesions of the larynx comprise 80% of the benign lesions diagnosed [5]. The etiology of the nonneoplastic vocal fold lesions is usually multifactorial, including phonotrauma (excessive loudness and cough, excess tension while speaking or singing, etc.), laryngeal trauma (endotracheal intubation), hypothyroidism, cigarette smoking, alcohol abuse, and gastroesophageal reflux (GERD) [6, 7, 8, 9, 10].
\nVocal fold nodules and polyps and Reinke’s edema are exudative vascular-stromal lesions involving Reinke’s space. The similarities and distinct features of these lesions have long been studied [11]. Although some discriminating features have been emphasized, most of the literature concludes that these lesions share the same histopathologic features which prevent a definitive diagnosis [11, 12].
\nReinke’s edema is one of the most common causes of hoarseness and approximately comprises 10% of the laryngeal pathologies [13, 14]. It is the result of fluid accumulation in Reinke’s space that lies beneath the surface epithelium of the true vocal cords [13]. Smoking, vocal abuse, upper respiratory tract infection, and gastroesophageal reflux (GERD) have been associated with Reinke’s edema [13, 15, 16, 17]. Marcotullio revealed that the occurrence and recurrence of Reinke’s edema depend on the number of cigarettes daily used [15]. Zeitels et al. showed that increased subglottic aerodynamic driving pressure is the underlying mechanism of edema [18]. It has been hypothesized that vocal hyperfunction along with the underlying conditions such as reflux, smoking, etc. is more prone to Reinke’s edema [13]. Vecerina et al. classified Reinke’s edema into transparent and livid type [19]. Hypothyroidism is stated not to be related with Reinke’s edema [13, 20, 21, 22]. Majority of the patients are adults (aged between 20 and 60 years). Most of the patients experience Reinke’s edema unilaterally (74%). Only a small group of the patients has bilateral edema (26%) [13].
\nMost of the time, serous fluid is observed upon incision in macroscopic evaluation. However, if the condition persists longer, a jellylike fluid can be seen [13]. Patients are treated with vocal rehabilitation and surgery after eliminating the underlying conditions. Cessation of cigarette smoking is an important factor in long-term treatment [23, 24]. Histopathologic features include subepithelial edema and expansion of the intercellular space, especially the basal membrane. Few blood vessels can be observed [25]. The overlying epithelium is normal most of the time [13]. Duflo et al. showed that antioxidant gene expression is increased in Reinke’s edema compared to the vocal fold polyps [26]. In addition, Branski et al. demonstrated that heme oxygenase is increased in vocal fold fibroblasts [27]. Collagen and elastin fiber configuration alterations are demonstrated in Reinke’s edema [28, 29]. Dikker et al.’s stated that increased fibrin, hemorrhage, and thickening of the basement membrane are related with Reinke’s edema [30].
\nVocal fold nodules and polyps are polypoid lesions of the vocal folds sharing the same histopathologic features. They are usually differentiated by clinical findings. A polypoid lesion larger than 3 mm is often regarded as a polyp, whereas smaller lesions are classified as a nodule [31]. Vocal fold nodules are usually bilateral lesions involving anterior or middle vocal fold and located superficially to the free edge of the vocal fold [32]. They are slightly more common in women and in young age [10, 33]. Vocal polyps occur more commonly at the anterior portion of the vocal fold, and in more than 90% of the patients, they are unilateral [31]. There is no age and gender predilection for vocal polyps. Vocal abuse is the leading etiologic factor for vocal fold nodules and polyps; singers, lecturers, and coaches are more prone to developing these lesions due to excessive and loud voice use [6, 10]. Infection, hypothyroidism, GERD, cigarette smoking, and allergy are the other frequent causes [7, 8, 9, 34]. Patients present with hoarseness and change in voice quality.
\nGrossly, vocal cord polyps and nodules present as sessile or polypoid lesions with nodules presenting as few millimeters and polyps up to few centimeters in size [5]. They can be white or bright red, and their consistency varies from firm to soft with a mucoid or glistening cut surface [32].
\nAlthough previous studies have attempted to identify histopathologic features which may aid in the differential diagnosis, it is now widely accepted that vocal fold nodules/polyps cannot be differentiated on the histopathologic basis [11, 31, 32, 35]. Epithelial hyperplasia, basement membrane thickening, edema, and vascular proliferation can be seen both in nodules/polyps and Reinke’s edema [25, 31, 36]. Ancillary studies such as Verhoeff-van Gieson, Masson trichrome, and Alcian blue did not reveal any difference among these entities [31].
\nHistopathology represents primarily the extent of the vascular damage and the temporal stage of the lesion [37]. Vocal abuse causes vascular injury and increased vascular permeability. If the damage is minimal, then increased permeability causes only edema, and the microscopic evaluation reveals hypocellular myxoid stroma which is defined as edematous myxoid-type vocal fold nodule/polyp according to some authors (Figure 1). When this lesion is not removed or resolved, it undergoes fibrosis, and fibrous-type polyp/nodule evolves. Oval and spindle cells are observed embedded in a fibrous stroma (Figure 2). Rarely atypical cells can be detected in this type which is not related with an aggressive behavior [36, 38, 39]. However, if the vascular injury is severe enough for fibrin escape to the subepithelium and interstitium at the beginning of the injury, then hyaline-type polyp/nodule occurs which is characterized by a hypocellular/acellular eosinophilic stroma. By the time capillary proliferation occurs, it progresses to a vascular-type nodule/polyp. This subtype shows ectatic vascular channels in a hypocellular stroma (Figure 3). Although, these classification and staging are helpful in understanding the histopathologic spectrum, it is clinically insignificant. In addition, mixed features are seen in a single lesion most of the time. The overlying squamous epithelium may be normal, atrophic, or hypertrophic, and keratosis can be seen.
\nPolyp with hypocellular myxoid stroma (H&E, ×100).
Polyp stroma appears fibrotic, and spindle cells can be observed embedded within the stroma (H&E, ×200).
Polyp stroma shows ectatic vasculature with a hypocellular stroma (H&E, ×200).
Differential diagnosis includes amyloidosis, myxoma, and contact ulcer. Differentiation of hyaline-type vocal fold nodule/polyp from amyloidosis can be made by observing the distribution of eosinophilic material carefully. In hyaline-type nodule/polyp, it is more homogenous, whereas in amyloidosis there is perivascular and periglandular accentuation of the deposit. Histochemical stains like Congo red and crystal violet can be helpful in identifying the nature of the amorphous material. Myxoma has been rarely reported in the larynx, and it has characteristic stellate spindle cells embedded in an avascular, basophilic, gelatinous-like matrix [40, 41]. Contact ulcer has an ulcerated and fibrin-coated surface and usually involves the posterior portion of the vocal folds.
\nSurgery has a limited value for these lesions as they are reactive changes to an underlying injurious condition which must be managed. Not surprisingly, voice therapy may result in resolution in most of the patients [42, 43]. Also, treatment of the exact underlying condition such as hypothyroidism can be helpful in the treatment of vocal fold polyps/nodules.
\nContact ulcer is an ulcerated granulation tissue due to vocal abuse, endotracheal intubation, and GERD. Men are more commonly affected than women except that postintubation-related ulcers are more common in female patients. Clinically patients present with hoarseness, cough, dysphonia, habitual coughing, and throat cleaning [44].
\nContact ulcers are generally bilateral (“kissing ulcer”) and involve the posterior part of the vocal fold. Grossly they present as an ulcerated, tan-white to erythematous polypoid lesion up to 3 cm in diameter. Microscopic evaluation reveals ulceration underlying a fibrin and/or fibrinoid necrosis and capillary proliferation that is oriented perpendicularly to the mucosal surface (Figure 4). Central and base part of the lesion contains hemosiderin-laden macrophages. Usually a dense inflammatory infiltration accompanies. Re-epithelization, mucosal hyperplasia, and fibroblastic proliferation can be observed in chronic phase of the lesion [45].
\nUlceration, necrosis, and granulation tissue formation. Capillaries oriented perpendicular to surface (H&E, ×200).
Clinicopathologic correlation is important in the correct diagnosis as histopathologic features are somewhat nonspecific. Differential diagnosis includes vascular-type vocal cord polyp/nodule, Kaposi sarcoma, Wegener granulomatosis, and infectious agents. Wegener granulomatosis can be differentiated from contact ulcer with features of vasculitis and necrotizing granulomas. Also, laboratory findings, such as cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) positivity, support a diagnosis of Wegener granulomatosis over contact ulcer. Kaposi sarcoma may rarely involve the larynx, and histopathologic evaluation reveals spindle cells with intracellular spheroid hyaline globules forming slit-like spaces and anastomosing vascular channels. Immunohistochemical staining with human herpes virus 8 (HHV8) reliably confirms the diagnosis as Kaposi sarcoma.
\nLike vocal polyps/nodules, contact ulcer is treated with voice therapy, anti-GERD medication, and behavioral modifications in order to decrease habitual coughing and throat clearing [44].
\nAmyloidosis is the deposition of an extracellular, acellular, fibrillar, and amorphous material in various sites of the body. It can be primary (associated with plasma cell neoplasms) or secondary (associated with chronic systemic diseases such as familial Mediterranean fever, rheumatoid arthritis, etc.). Primary amyloidosis can be classified as systemic or localized. The larynx is the most common site for localized amyloidosis [46, 47]. It may also be associated with “mucosa-associated lymphoid tissue” (MALT) lymphoma or a neuroendocrine tumor. Laryngeal amyloidosis generally affects adults at the sixth decade. Patients present with hoarseness and voice changes because of mass effect [45]. Grossly it presents as a firm polypoid lesion up to 4 cm covered by normal-appearing mucosa. Cut surface may be firm and starch-like and gray or yellow-orange in color. Localized laryngeal amyloidosis can involve the larynx diffusely or present as a nodule. Microscopic examination reveals diffuse subepithelial or discrete nodular lesion consisting of amorphous, fibrillary, and hyaline-like eosinophilic substance deposition. Usually the distribution of the deposition is more pronounced in perivascular and periglandular areas. Lymphoplasmacytic infiltration and foreign body giant cells can be seen but usually sparse.
\nDifferential diagnosis includes hyalinized-type vocal fold polyps/nodules and lipoid proteinosis which are negative with Congo red and crystal violet. Most importantly as amyloid can be associated with multiple myeloma, laryngeal neuroendocrine tumors, and medullary thyroid carcinoma, a systemic evaluation of the patient is necessary.
\nIf amyloidosis is limited to the larynx, patients are treated with surgical removal of the lesion. However, other treatment options will be applied if the patient has an underlying neoplastic condition or chronic inflammatory disease.
\nNonneoplastic cysts of the larynx consist of laryngocele, saccular, and ductal cysts [48, 49, 50].
\nLaryngeal ventricles are the spaces between the true and false vocal cords which extend upward and form the laryngeal saccule bilaterally. Laryngocele can be defined as a symptomatic dilation of the laryngeal saccule with air entrapment [51]. An important feature of laryngocele is that the lumen of the cyst communicates with the laryngeal cavity. Radiography reveals an air-filled cystic enlargement. They are usually unilateral, may occur over a wide age range, and are more frequent in males. Occupations such as glassblower or wind instrumentalists are at increased risk of developing laryngocele due to repetitive increase in intralaryngeal pressure. Patients present with hoarseness and foreign body or globus sensation.
\nClinically it can be divided as internal, external, or combined. Internal laryngocele is confined to the endolarynx and presents as a supraglottic submucosal lesion. In contrast external laryngocele extends through the thyrohyoid membrane. However, in combined laryngocele, the cyst herniates through the thyrohyoid membrane and presents as an anterior neck mass [51, 52, 53]. Patients present with hoarseness, dyspnea, and chronic cough. In histopathologic examination, the respiratory epithelium is identified as the lining of the cyst wall.
\nDifferential diagnosis includes other laryngeal cysts. However, laryngocele is the only air-filled cyst of this region and communicates with the laryngeal cavity—an important finding in differentiation.
\nSymptoms may resolve with the expulsion of trapped air from the cyst lumen. Treatment of laryngocele is simple excision or marsupialization of the cyst wall.
\nSaccular cyst is a mucin-filled cyst due to obstruction of the laryngeal saccule. It can be acquired or congenital [49, 50]. If it extends medially, it may obscure the anterior vocal fold. Lateral saccular cysts are similar to the external laryngoceles, herniated through the thyrohyoid membrane, and may present as a neck mass [37].
\nSaccular cysts are usually lined by respiratory-type epithelium. Squamous or oncocytic lining can be observed in some cases. Cyst lumen is filled with mucin or acute inflammatory exudate.
\nDifferential diagnosis includes laryngocele and thyroglossal ductus cyst. It is differentiated from laryngocele by mucin content, and it does not communicate with the laryngeal cavity. It is difficult to discriminate a thyroglossal cyst from a saccular cyst when it invades through the pre-epiglottic space and histopathologically lacks the thyroid tissue. When this is the situation, investigation of the anatomic localization of the cyst is a reliable finding in the differentiation of these cysts. Thyroglossal ductus cysts are related with the hyoid bone and located in the midline of the neck.
\nDuctal cysts are the most common type of laryngeal cysts. Cyst lining epithelium can be squamous or oncocytic [49, 54] (Figures 5 and 6). When a squamous lined cyst is surrounded by lymphoid tissue, it is called a tonsillar cyst. Tonsilar cysts are more common in the vallecula which contains tonsillar remnants.
\nThe right side of the figure represents a squamous cell lined cyst. On the left cyst lining cells appear oncocytic (H&E, ×400).
Ductal cyst with lining oncocytic cells (H&E, ×400).
Rarely epidermal, dermoid, and branchial cleft cysts may occur in the endolarynx.
\nHyperplastic lesions of the larynx are a result of a reparative process. Clinical terms such as leukoplakia (white plaque), erythroplakia (red plaque), erythroleukoplakia (red and white changes), or pachydermia (extensive thickening of the mucosa) are used to describe the lesion macroscopically, and they are not histologic entities [55].
\nKeratosis of the larynx is synonymously used with simple hyperplasia and squamous hyperplasia [56]. Singers and other occupations that lead to an individual to use his/her voice excessively and cigarette smokers are at risk of keratosis. Hoarseness is the leading complaint. Laryngoscopy identifies leukoplakia. Microscopic evaluation reveals a thickened squamous epithelium without cellular or architectural atypia [55]. Generally, a hyperkeratotic layer overlies the epithelium. Lesions with warty configuration are referred as verrucous keratosis [56, 57].
\nPseudoepitheliomatous hyperplasia (PEH) is a reactive proliferation of the squamous epithelium which develops in response to infections, trauma, or neoplasia. Histologically these lesions are downward thickening of the epithelium (Figure 7). Due to a less well-defined epithelial stromal interface and the tendency of anastomosing epithelial tongues entrapping the submucosa, the lesion may mimic squamous cell carcinoma [58]. However, in PEH, the hyperplastic epithelium forms large bulbous projections, and basement membrane is always preserved.
\nDownward proliferation of benign appearing surface epithelium (H&E, ×200).
Verrucous hyperplasia is a verrucous and keratotic form of squamous hyperplasia which may show varying degrees of cytological atypia (Figure 8). The presence of cellular atypia and a relatively regular epithelial-stromal border supports a diagnosis of verrucous hyperplasia over verrucous squamous cell cancer (SCC) [59].
\nParakeratosis and verrucous hyperplasia of the surface epithelium (H&E, ×100).
Voice change or hoarseness of voice and nonneoplastic vocal fold lesions lead to a high percentage of vocal fold biopsies. Both clinical and histopathologic features should be considered in order to differentiate lesions involving Reinke’s space and also hyperplastic epithelial lesions from squamous cell carcinoma.
\nAs the typical 1D carbon materials, carbon nanotubes (CNTs) (Figure 1a) and carbon nanofibers (CNFs) have been widely investigated in the past two decades because of their merits, such as outstanding mechanical strength, large surface-to-volume ratio, and extraordinary electrical conductivity [1, 2, 3, 4]. At the same time, graphene (Figure 1b), a recently discovered 2D sp2 carbon, displays outstanding physical and chemical properties such as high specific surface areas (about 2620 m2 g−1), great lightweight, and fast electron transport kinetics [5, 6, 7]. Nevertheless, their physical and chemical performances inevitably decrease compared to the theoretical prediction result from the existence of the van der Waals interaction, generating easy self-aggregation and stacking during the synthesis process [8]. Therefore, the 3D nanocarbon hybrids (such as CNT/graphene, CNF/graphene, CNT/CNF hybrids) are studied by a large number of the research groups, aiming at overcoming these shortcomings and a synergistic integration of their inherent properties in the new hybrid materials [9, 10, 11]. These nanocarbon hybrids have an interconnected network of carbon structure, resulting in a synergistic effect in enhanced conductivity in comparison with the individual components, and the special 3D structure significantly provides a variety of applications, such as field-effect transistors [12, 13], electron field emitters [14, 15, 16], sensors [17, 18, 19, 20], fuel cell [21, 22, 23], batteries [24, 25], and supercapacitors [26, 27, 28, 29, 30].
Schematic diagrams of graphene and carbon nanotube.
To date, a number of techniques and methods have been utilized for the fabrication of nanocarbon hybrid, such as mixing process of surface-treated carbon materials (including solution processing [31, 32], vacuum filtration [33, 34], layer-by-layer self-assembly method [35, 36]), hydrothermal method [37], multi-step approaches using combinations of decorated carbon materials and CVD [10], and multi-step and one-step chemical vapor deposition [38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48]. Among all the nanocarbon hybrid fabrication approaches reported, CVD techniques are considered as the most versatile and promising way for nanocarbon composite production with reasonable structure and mechanical strength, which has attracted tremendous research attention during the recent decades. As a sophisticated synthesis method for both laboratory research and industry production, conventional CVD (shown in Figure 2) is applied in many areas, such as thin-film coating, crystal growth, and powder production and also suitable for the synthesis of nanocarbon materials. The mechanism of conventional CVD generally includes two steps, initially thermal decomposition of gaseous precursor [10], organic solvents [47], or solid feedstock [9, 28] and thereafter reassembly of carbon atoms into sp2 carbon nanostructures under the effective catalysis such as Cu [8], Fe [12], Co [28, 44], Ni [24], or their mixture [11, 49] at high temperature. Compared with other approaches, CVD technique significantly fabricated well-interconnected three-dimensional nanocarbon materials without needing sophisticated chemical routes with solvents and highly toxic agents during synthesis process. Zhu et al. [50] reported that the seamless, covalently bonded three-dimensional nanocarbon architecture was fabricated on the surface of Cu foil via simple two-step CVD methods. It is worth noting that although different aforementioned methods are employed for the production of nanocarbon hybrids, a facile and simple approach for controllable growth of three-dimensional carbonaceous nanomaterials is still a big challenge.
Schematic diagrams of CVD technique.
In this chapter, we present a summary of the researches about nanocarbon hybrid in recent years, with a focus on the popular fabrication techniques. Moreover, the merits and demerits and effect of experimental parameters of these CVD methods are presented in detail. Finally, we discuss the development trend, challenges, and performance applications of nanocarbon hybrids in the further.
Up to now, varied approaches have been used for the fabrication of 3D nanocarbon hybrids, and the preparation technology generally could be categorized into four different approaches (shown in Figure 3): mixing process of surface-treated carbon materials, hydrothermal method, multi-step approaches using combinations of decorated carbon materials and CVD, and multi-step and one-step chemical vapor deposition. In addition, early researches on the construction of 3D hybrids focus on mixing process, which includes solution processing, vacuum filtration, and layer-by-layer self-assembly methods. Compared to other methods, hydrothermal route is an appropriate way to the mass preparation of graphene-carbon nanotube hybrids because of the easy operation and mild experimental environment. Moreover, the composites consisted of carbon nanotube and carbon nanofiber mainly produced by utilizing the multi-step approaches using combinations of decorated carbon materials and CVD method. Especially, multi-step and one-step chemical vapor deposition is considered as a simple and promising way to build 3D hybrids with hierarchical structure and stability.
Classification of 3D nanocarbon hybrids synthesis techniques.
As the early hybridization approaches, solution processing, vacuum filtration, layer-by-layer self-assembly methods, and so on could be classified into the facile mixing process. Altogether 1D carbon nanomaterial incorporation of 2D nanomaterial with a facile mixing process exhibits a synergistic effect in enhanced properties. However, the nanocarbon hybrids are synthesized by utilizing various methods to mix modified carbon-based feedstocks, which generally need sophisticated chemical routes with solvents and highly toxic agents [31, 33, 34, 35, 36]. Furthermore, this kind of techniques suffers from poor controllability, leading to the restriction of practical application due to the aggregation and stacking of carbon-based materials [51].
With regard to hydrothermal method, firstly, the carbon feedstocks are dissolved and the mixed solution is transferred into a heating instrument. Secondly, the hydrothermal treatment is performed at low temperature, and the final product is obtained after centrifugation, washing, and freeze-drying process. Although this method has merits of mild conditions and scale-up synthesis, it is not suitable for the industrial production due to the time-consuming fault and defective products. Besides, the obtained 3D nanostructures are chiefly based on weak interconnection between individual nanocarbon components instead of owning powerful bonding, leading to robust 3D architecture [52].
Chemical vapor deposition is considered as the most promising approach of the preparation of graphene, CNTs, and CNFs on the substrate surface. Thus, it is always employed to facilitate the growth of CNTs on the decorated carbon materials, leading to the 3D hierarchical composite. For example, most of the reported 3D carbon nanotube/carbon nanofiber hierarchical composites are typically prepared by a multi-step route, which first needs electrospinning technique and post-carbonization for the preparation of CNFs, followed by decorating the CNFs with metal catalyst nanoparticles, and eventually the CNT growth is promoted by using toxic organic gases or solvent as carbon source during the CVD process [10, 22]. This kind of CVD-based methods has distinctive advantages: efficiency, convenience, and high yield. However, the stable and suitable decorated carbon materials that always need sophisticated pretreatment are vital to the construction of 3D carbon hybrids.
Multi-step chemical vapor depositions have been utilized in recent years to integrate individual 1D with 2D carbon nanomaterials to achieve controllable configurations of 3D nanostructures. Recently, Tang et al. successfully fabricated graphene-carbon nanotube composite on exfoliated vermiculite (EV) substrate by the multi-step CVD method (as shown in Figure 4). The whole CVD process could be divided into two steps: firstly, the aligned CNTs are synthesized at 650°C by using C2H4 as carbon source, and, secondly, the uniform graphene sheet directly grows on the surface of substrate at a higher temperature of 950°C by utilizing the hydrocarbon—CH4, resulting in the in situ synthesis of graphene-carbon nanotube-graphene sandwiches [53]. In other methods of the successful fabrication of 3D hybrids, the obtained component materials are always entangled with each other, and the ordered 3D packing architecture is hardly available. Nevertheless, this multi-step way successfully integrates low-dimensional materials into 3D ordered, controllable, and well-connected structures [50]. Additionally, the morphology and nanostructure could be well controlled by adjusting the experimental parameters due to the separated CVD processes. It is a pity that the multi-step process always requires strict growth conditions and large consumption of power (high temperature) for the growth of nanocarbon materials.
Scheme for the two-step CVD synthesis of graphene/carbon nanotubes hybrids.
Recently, tremendous efforts have been made to produce 3D nanocarbon hybrid via simultaneously in situ growing of 1D and 2D carbon nanomaterials on the surface of substrate during the CVD method. For example, Dong et al. (illustrated in Figure 5) reported that graphene/carbon nanotube hybrids were synthesized by a facile single-step CVD route employing ethanol (C2H5OH) as feedstock on the surface of Cu substrate decorated with Si nanoparticles, and the property and shape of hybrid could be varied by adjusting the fabrication environment (e.g., Si nanoparticles, temperature, and annealing time). The single-step route has the merits of better electrical conductivity and lesser defect density than the multi-step methods [43]. Additionally, although this one-step process effectively decreases the consumption of power, they still need high temperature, flammable gases, or toxic chemicals for the in-situ growth of 3D architecture.
Scheme for the one-step CVD synthesis of graphene/carbon nanotubes hybrids.
It is known that substrate is the important part in the conventional CVD method, and the choice of substrate is essential to the morphology, nanostructure, and applications for carbonaceous nanomaterials. We generally use single transition metal substrate (Fe, Co, Ni, Cu, palladium (Pd) [41], ruthenium (Ru) [54]) as the catalyst for the preparation of graphene, and Fe, Co, Ni, and Cu are of great interest, because of the low cost and availability.
Remarkably, to build the uniform 3D architecture, single metal substrate is not enough for the CVD growth process. Hence, substrate embedded with metal nanoparticles serves as the bifunctional catalyst to facilitate the synthesis of different dimensional carbon materials, and the crucial issue for the in situ growth of 3D hybrids depends on the stability of catalyst nanoparticles during the deposition process. In CVD methods, the metal nanoparticles for the growth of hybrids could be obtained by a variety of ways, such as spin coating [47], electron evaporation [50], template etching [55, 56], and so on. Moreover, the covalent C–C bonding between different dimensional carbon materials, which is of paramount importance for 3D nanostructure, is probable to be achieved by such methods [57, 58, 59]. Nguyen et al. fabricated graphene/carbon nanotube composite by employing the Cu substrate-embedded Fe nanoparticles as the catalyst in the simple CVD approach [15]. In which Cu foil served as the template for the graphene sheet preparation. Additionally iron nanoparticles served as the catalyst for the CNT preparation. Besides, similar report indicated that the diameter, density, and quality of CNTs of composite could be defined by the size of the catalyst nanoparticles [45]. And various densities of catalyst nanoparticles had a different effect on the purity, thermal stability, and defects of 3D carbon hybrids [59].
Although low-dimensional carbon nanomaterials’ nanostructure and diameter in 3D architecture is directly related to the size and nature of catalyst nanoparticles, it also could be indirectly determined by adjusting growth temperature in CVD technique. The different growth of CNF/CNT hybrid was fabricated due to the different carbon source decomposition and diffusion rate at various growth temperatures in the study of Park et al. [24]. Furthermore, the growth temperature is also crucial for the defects and properties of 3D carbon nanomaterials. Lin et al. [57] found that at different growing temperatures, the various architecture of sample could be produced by indirectly changing the number of layers of graphene and packing density of CNTs. And the ratio of the ID/IG (Raman spectroscopy analysis), defects, and surface area increased with the decrease of growth temperature, leading to the increased specific capacitance. As a result, it is crucial to seek the appropriate growth temperature for the growth of well-developed 3D composite.
In the CVD approach, hydrogen (H2), argon (Ar), and nitrogen (N2) are utilized for the growth of carbon materials in the high-temperature annealing process, and the influence of variety of gases in the conventional CVD process is different. As for Ar and N2, they serve as the carrier gas to introduce the vapor into the CVD furnace under a suitable flow rate. As for H2, it has multifunctional effects in the practical CVD environment. First, it is believed that H2 removes surface impurities (such as S and P) and defects which can cause local variations of carbon solubility in the metal substrate in the high-temperature process [13, 60]. And it also enables the reduction process of metal oxides for producing enough catalyst nanoparticles at the high temperature [10, 22, 24]. Yan et al. [49] fabricated mesoscopic 3D composite comprised of graphene and CNTs under the effect of Ni-Co catalysts which was produced at 800°C in H2 atmosphere. Unlike the conventional CVD synthesis of individual 1D or 2D carbon nanostructure, H2 also plays an important role in building nanostructure of 3D hierarchical hybrids, especially for graphene/CNT composite. For example, there were two simultaneous reactions appearing during the construction of 3D graphene/CNT hybrids in the previous report [8]. On one time, the methane decomposed with the increasing temperature and thereafter facilitates the CNT growth out of islands of metal catalyst. Simultaneously, hydrogenation process appeared on the surface of graphene sheet (shown in Figure 6). In this process, graphene sheet was effectively etched under the atmosphere of H2 and transformed into CH4 at the point of connection with the catalyst nanoparticles (Ni nanoparticle + C graphene +2H2 → Ni + CH4) [61]. Furthermore, the morphology of the hybrids was adjusted via varying the H2 flow rate to change the two contrary reactions in the CVD method. Consequently, the high density of CNTs grown on the surface of graphene sheet under the suitable flow rate of H2, implying that the rate of H2 etching optimized the 3D nanocarbon formation.
Schematics illustrating direct CNT growth on planar graphene under H2 etching.
So far, quite a few investigations have been dedicated to the fabrication of 3D carbonaceous hybrids by using various carbon sources, and studies have illustrated that the carbon sources can also be basically classified into the three categories: hydrocarbon compounds (CH4 [45, 58], C2H2 [11, 50], C2H4 [10], C3H8 [43]), liquid carbon sources (ethanol [47], pyridine [22], toluene [41]), and solid feedstock (melamine [49], Prussian blue [9], camphor [62]) and so on. According to the relevant reports, diverse carbonaceous hybrids choose various carbon sources as feedstock for the basic supply of 3D architecture. With respect to CNT/CNF hybrids, hydrocarbon compounds are always considered as feedstocks of CNTs on the surface of obtained CNFs. With respect to CNT/graphene or CNF/graphene composites, hydrocarbon compounds, liquid carbon sources, and solid feedstock are all used as precursors for the growth of hierarchical architecture. Notably, for the synthesis of graphene, the present CVD technique requires high growth temperature, typically 1000°C [63, 64, 65]. Since it is more environment-friendly, convenient, and economical for industrial fabrication, a low-temperature route is greatly desirable. Liquid and solid carbon sources decompose at a lower temperature relative to major gaseous carbon sources. Therefore, liquid and solid feedstock could be a better choice for the growth of 3D CNT/graphene or CNF/graphene hybrids because of the quick carbon diffusivity through metal catalysts and covering on the surface at lower temperature. Moreover, during the dehydrogenation process of liquid or solid carbon sources, the overall dehydrogenation barrier and nucleation barrier are much lower than that of gaseous carbon source from the relevant report [66]. Recently, low temperature (800°C) one-step CVD synthesis of 3D hybrids composed by CNTs and graphene sheet are demonstrated by using melamine as the single solid carbon source [56]. Nevertheless, 3D hybrid growth at lower temperature still remains a challenge.
Three-dimensional nanocarbon hybrids have been used for a variety of applications, for example, transparent and flexible electrodes and field-effect transistors [12, 13, 14, 15, 16, 47], sensors [17, 18, 19, 20], fuel cell [67], batteries [9, 11, 44, 55], supercapacitors [10, 50, 51], and so on.
Because of the outstanding mechanical, electrical, and thermal properties, low dimensional nanocarbon materials have recently attracted enormous interest for potential application in transparent and flexible nanoelectronics [68, 69, 70]. Furthermore, 3D graphene-based hybrids which offset shortcomings of pure graphene received a large number of attentions in particular for two applications: transparent and flexible electrodes and field-effect transistors. Kim et al. [13] successful synthesized single-walled carbon nanotubes (SWCNT)/graphene hybrids on the Cu foil coated with CNTs. Notably, compared to pure CNT (58.78 ± 36.17 cm2/V s) and graphene (341.7 ± 259.4 cm2/V s), SWCNT-graphene hybrids possessed higher field-effect mobilities (μ) (394.46 ± 176.27 cm2/V s) and better output characteristics (Figure 7), suggesting that the electrical conductivity of this hybrids dramatically increased compared to individual carbon material. As for transparent and flexible device applications, the hybrids showed the low sheet resistance (300 Ω/sq) with 96.4% optical transparency which is largely lower than the monolayer graphene (∼1 kΩ/sq) grown by CVD method, indicating that composite is a promising material in developing high-performance transparent and flexible devices. Additionally, the hybrids possessed improved mechano-electrical property result from the CNT growth and obtained hybrid demonstrated that at an applied field of 4.0 V/μm, the hybrid exhibited a current density of 1.33 mA cm−2 [15], implying superiority than that of pure CNT materials on indium tin oxide films (ITO) glass [71]. And it probably replaces the ITO films, the most common transparent and flexible electrodes, as an alternative material with properties including high on/off ratios and outstanding electrical conductivity for high-performance flexible device in the future.
Output characteristics (IDS − VDS) of graphene, SWCNT-graphene hybrid film, and SWCNT. Reproduced with permission from ref. [13].
In the practical application, the higher active and stable catalysts are crucial to the high electrochemical performance of fuel cell. Compared to the pure Pt-graphene cathode material, the Pt-3D nanocarbon composite cathode exhibits much smaller oxygen reduction reaction (ORR) charge transfer resistance and higher maximum power density in the direct methanol fuel cell [23] and proton exchange membrane fuel cells [21]. Moreover, due to the expensive cost and poor durability, as the spread anode and cathode electro-catalysts for ORR, Pt-based materials are hampered in the commercialization. Significantly, the CNT/CNF composite acts as the effective Pt-free ORR catalyst with a comparable activity, cheap price, and better thermal stability and durability, and the unique 3D network results in the enhanced electrochemical performance [22], implying 3D hybrid materials are becoming increasing competitive in the fuel cell applications.
Carbon-based materials (such as CNTs, CNFs, graphene), with their merits of reversible lithium-carbon reaction, low-intercalation potential with Li+, high-coulumbic efficiencies, and low-capacity fade, are excellent choices as electrode materials of lithium-ion batteries [72, 73]. Nevertheless, the cycling performance and high-rate capability of individual material are not as satisfactory as expected, possibly owing to the large contact resistance of easy self-aggregation and stacking. Moreover, hybrids consisting of various low dimensional carbon materials, which favor different oriented diffusion of the lithium ion and the 3D nanocarbon architecture, are beneficial to the electrons’ collection and transport around the cycling process, leading to high electrical conductivity and chemical stability. For example, the 3D nanocarbon hybrid anode exhibited significantly enhanced reversible capacity (300 mA h g−1), outstanding cycling stability, and lower electrolyte resistance and contact resistances in contrast with the individual CNF material [11]. Additionally, by building 3D carbon network, at current densities of 0.36, 0.6, 1.2, 2.4, and 6 mA/cm2, the rate performance of graphene/CNF hybrids reached about 420, 385, 329, 229, and 189 mA h g−1, (as shown in Figure 8), which were superior to those of other pure nanocarbon performances [44]. Therefore, hybridization of the different low-dimensional carbon nanomaterials is an effective route to provide fast ion/electron transfer and higher Li storage capability, and the hierarchical 3D carbonaceous architecture is also promising for Li-ion battery applications in the future.
Comparison of the rate capabilities of CNF/GNS, GNS, CNT, commercial natural graphite discharged at C/5, CNF (30 nm in diameter), CNF/natural graphite, and natural graphite spheres. Reproduced with permission from ref. [44].
Because of the large energy density, capacity (1673 mA h g−1), low cost, and environmental benignity of sulfur, lithium-sulfur (Li-S) batteries are investigated by a large number of research groups. However, the “shuttling effect” which always triggers an inevitable sulfur loss in practical Li-S battery applications, leading to an increase in internal resistance, low cycling capacity, and poor coulombic efficiency. To solve this problem, porous carbon materials, e.g., CNTs and graphene, also have been utilized to capture and encapsulate sulfur, blocking the high solubility of polysulfides during the Li-S battery applications [74, 75]. And compared to pure CNT which is always hindered by problems of easy self-aggregation, enormous interface resistance, and poor S-storage ability, the 3D hybrids composed of CNTs and graphene are more suitable for the cathode of high-rate performance for Li-S batteries. The hybrid structure exhibits unique advantages: (i) the well-connected junction between the CNTs and graphene sheets enable rapid electron transfer; (ii) robust nanostructure provides flexibility and mechanical robustness, which effectively buffers volume changes during the cycling process [9]. Zhao et al. reported that graphene/CNT composite cathode possessed remarkable performance: a reversible capacity (928 mA h g−1) at 1 C capacity and at a high current rate of 5 C, the capacity as high as about 650 mA h g−1 could be obtained even after 100 cycles with a coulombic efficiency of about 92% in Li-S battery applications [76]. Furthermore, it is worth noting that electrochemical performance and catalytic activity have significantly improved nitrogen doping according to a relevant report, thus nitrogen-doped 3D hybrids also applied in the Li-S batteries. Tang et al. employed glucose and dicyandiamide as the carbon and nitrogen feedstocks to prepare the nitrogen-doped nanocarbon hybrid by a one-step chemical vapor deposition process technique, and the result (1314 mA h g−1 at 0.2 C, a capacity retention of 97% after 200 cycles at a high rate of 2 C) exhibited the improved cyclic and rate performances [9]. These experimental results also indicate that the nitrogen-doped 3D nanostructure has the potential toward promising Li-S batteries.
A variety of nanocarbon materials, e.g., CNTs, graphene, or mesoporous and activated carbon possess enormous specific surface areas yet are limited by low performance owing to aggregation and internal resistance, leading to decreased capacitance than theoretical prediction [77]. To overcome the aforementioned disadvantages, 3D composites are considered as attractive materials for supercapacitor application by inhibiting the agglomeration and improving the electrolyte electrode accessibility and the electrode conductivity. Relevant report demonstrated that the capacitance (653.7 μF cm−2) at 10 mV s−1 of 3D CNT/graphene-based supercapacitor was superior to the graphene electrode (99.6 μF cm−2) [8]. Zhou et al. fabricated supercapacitor based on polyaniline/carbon nanotube/carbon nanofiber (PANI/CNT/CNF) electrode [30]. Compared with pure PANI/CNF, the hybrids showed higher specific capacitance and energy density, superior rate capability, and lower ion diffusion/transport resistance (shown in Figure 9).
(A) GCD curves of CNF, CNT/CNF, PANI/CNF, and PANI/CNT/CNF film electrodes at a current density of 0.3 a g−1, respectively. (B) GCD curves of PANI/CNT/CNF film electrodes at different current densities. (C) Specific capacitance vs. current density for PANI/CNF and PANI/CNT/CNF film electrodes. (D) Charging/discharging cycling stability of PANI/CNT/CNF film electrodes at a current density of 15 a g−1. Reproduced with permission from ref. [30].
Meanwhile, due to the merits—high theoretical capacity, low cost, and natural abundance—diverse potential metal oxides, e.g., RuO2 [78], MnO2 [79], NiO [80], and Co3O4 [81] are regarded as the potential materials for pseudocapacitors. Particularly, as one of the most promising pseudocapacitor materials, when the MnO2 combined with 3D carbon hybrid, the drawbacks such as weak conductivity, low specific surface area, and brittleness of metal oxide electrodes are effectively alleviated, resulting in higher electrochemical performances [26, 27]. Wang et al. synthesized nanocarbon hierarchical composites (CNTs/CNFs) decorated with MnO2 for flexible supercapacitors [10]. And the 3D nanocarbon hybrid/MnO2 electrodes showed large better specific capacitance, cycling stability, maximum energy density, and rate capability than the CNF/MnO2 electrodes. These enhanced electrochemical performances of hybridized-based electrodes indicate that the designed hierarchical structures of composites support a large special surface area for the reaction between electrolyte ions and metal oxides. Simultaneously, the special 3D nanostructures improve the electrode nanomaterials’ electronic conductivity and facilitate transport channels for electrolyte ions. It is no doubt that 3D nanocarbon hybrids will have a crucial impact on the emerging materials of high-performance supercapacitor applications.
To combine the merits of each building block, 3D nanocarbon structures (CNT/graphene, CNF/graphene, CNT/CNF hybrids) have been prepared by a variety of methods. The synthesis procedure, merits, and demerits of different approaches reported in the literatures are discussed in this chapter. Among them, chemical vapor deposition is regarded as the most promising fabrication method, and nicely hybrid architectures are achievable by this way. Nevertheless, there are various drawbacks and challenges in the practice synthesis. One of the great challenges in the CVD synthesis of the three-dimensional nanocarbon hybrids is convenience or simpleness when compared to preparation methods of individual nanocarbon materials. A simple scalable CVD method to fabricate controllable architecture of 3D nanocarbon hybrid is still crucial to industrial production. Furthermore, a variety of applications have been presented in this chapter. Compared to individual nanocarbon components, the superior performances of 3D nanocarbon hybrids signify their promising and wide application in the future, and 3D hybrid electrode materials are becoming more competitive in energy storage applications. It is worth mentioning that studies on the growth mechanism of 3D nanostructure which is necessary for the full understanding of CVD growth process is seldom reported from the relevant literatures. And some crucial problem still remained to be solved, particularly the interactions between various individual components and structure control in the future.
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She performed research in perioperative autotransfusion and obtained the degree of PhD in 1993 publishing Peri-operative autotransfusion by means of a blood cell separator.\nBlood transfusion had her special interest being the president of the Haemovigilance Chamber TRIP and performing several tasks in local and national blood bank and anticoagulant-blood transfusion guidelines committees. Currently, she is working as an associate professor and up till recently was the dean at the Albert Schweitzer Hospital Dordrecht. She performed (inter)national tasks as vice-president of the Concilium Anaesthesia and related committees. \nShe performed research in several fields, with over 100 publications in (inter)national journals and numerous papers on scientific conferences. \nShe received several awards and is a member of Honour of the Dutch Society of Anaesthesia.",institutionString:null,institution:{name:"Albert Schweitzer Hospital",country:{name:"Gabon"}}},{id:"83089",title:"Prof.",name:"Aaron",middleName:null,surname:"Ojule",slug:"aaron-ojule",fullName:"Aaron Ojule",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Port Harcourt",country:{name:"Nigeria"}}},{id:"295748",title:"Mr.",name:"Abayomi",middleName:null,surname:"Modupe",slug:"abayomi-modupe",fullName:"Abayomi Modupe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:null,institutionString:null,institution:{name:"Landmark University",country:{name:"Nigeria"}}},{id:"94191",title:"Prof.",name:"Abbas",middleName:null,surname:"Moustafa",slug:"abbas-moustafa",fullName:"Abbas Moustafa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94191/images/96_n.jpg",biography:"Prof. Moustafa got his doctoral degree in earthquake engineering and structural safety from Indian Institute of Science in 2002. 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His research interest includes earthquake engineering, seismic design, nonlinear dynamics, random vibration, structural reliability, structural health monitoring and uncertainty modeling.",institutionString:null,institution:{name:"Minia University",country:{name:"Egypt"}}},{id:"84562",title:"Dr.",name:"Abbyssinia",middleName:null,surname:"Mushunje",slug:"abbyssinia-mushunje",fullName:"Abbyssinia Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Fort Hare",country:{name:"South Africa"}}},{id:"202206",title:"Associate Prof.",name:"Abd Elmoniem",middleName:"Ahmed",surname:"Elzain",slug:"abd-elmoniem-elzain",fullName:"Abd Elmoniem Elzain",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kassala University",country:{name:"Sudan"}}},{id:"98127",title:"Dr.",name:"Abdallah",middleName:null,surname:"Handoura",slug:"abdallah-handoura",fullName:"Abdallah Handoura",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"École Supérieure des Télécommunications",country:{name:"Morocco"}}},{id:"91404",title:"Prof.",name:"Abdecharif",middleName:null,surname:"Boumaza",slug:"abdecharif-boumaza",fullName:"Abdecharif Boumaza",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Abbès Laghrour University of Khenchela",country:{name:"Algeria"}}},{id:"105795",title:"Prof.",name:"Abdel Ghani",middleName:null,surname:"Aissaoui",slug:"abdel-ghani-aissaoui",fullName:"Abdel Ghani Aissaoui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/105795/images/system/105795.jpeg",biography:"Abdel Ghani AISSAOUI is a Full Professor of electrical engineering at University of Bechar (ALGERIA). He was born in 1969 in Naama, Algeria. He received his BS degree in 1993, the MS degree in 1997, the PhD degree in 2007 from the Electrical Engineering Institute of Djilali Liabes University of Sidi Bel Abbes (ALGERIA). He is an active member of IRECOM (Interaction Réseaux Electriques - COnvertisseurs Machines) Laboratory and IEEE senior member. He is an editor member for many international journals (IJET, RSE, MER, IJECE, etc.), he serves as a reviewer in international journals (IJAC, ECPS, COMPEL, etc.). He serves as member in technical committee (TPC) and reviewer in international conferences (CHUSER 2011, SHUSER 2012, PECON 2012, SAI 2013, SCSE2013, SDM2014, SEB2014, PEMC2014, PEAM2014, SEB (2014, 2015), ICRERA (2015, 2016, 2017, 2018,-2019), etc.). His current research interest includes power electronics, control of electrical machines, artificial intelligence and Renewable energies.",institutionString:"University of Béchar",institution:{name:"University of Béchar",country:{name:"Algeria"}}},{id:"99749",title:"Dr.",name:"Abdel Hafid",middleName:null,surname:"Essadki",slug:"abdel-hafid-essadki",fullName:"Abdel Hafid Essadki",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"École Nationale Supérieure de Technologie",country:{name:"Algeria"}}},{id:"101208",title:"Prof.",name:"Abdel Karim",middleName:"Mohamad",surname:"El Hemaly",slug:"abdel-karim-el-hemaly",fullName:"Abdel Karim El Hemaly",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/101208/images/733_n.jpg",biography:"OBGYN.net Editorial Advisor Urogynecology.\nAbdel Karim M. A. El-Hemaly, MRCOG, FRCS � Egypt.\n \nAbdel Karim M. A. El-Hemaly\nProfessor OB/GYN & Urogynecology\nFaculty of medicine, Al-Azhar University \nPersonal Information: \nMarried with two children\nWife: Professor Laila A. Moussa MD.\nSons: Mohamad A. M. El-Hemaly Jr. MD. Died March 25-2007\nMostafa A. M. El-Hemaly, Computer Scientist working at Microsoft Seatle, USA. \nQualifications: \n1.\tM.B.-Bch Cairo Univ. June 1963. \n2.\tDiploma Ob./Gyn. Cairo Univ. April 1966. \n3.\tDiploma Surgery Cairo Univ. Oct. 1966. \n4.\tMRCOG London Feb. 1975. \n5.\tF.R.C.S. Glasgow June 1976. \n6.\tPopulation Study Johns Hopkins 1981. \n7.\tGyn. Oncology Johns Hopkins 1983. \n8.\tAdvanced Laparoscopic Surgery, with Prof. Paulson, Alexandria, Virginia USA 1993. \nSocieties & Associations: \n1.\t Member of the Royal College of Ob./Gyn. London. \n2.\tFellow of the Royal College of Surgeons Glasgow UK. \n3.\tMember of the advisory board on urogyn. FIGO. \n4.\tMember of the New York Academy of Sciences. \n5.\tMember of the American Association for the Advancement of Science. \n6.\tFeatured in �Who is Who in the World� from the 16th edition to the 20th edition. \n7.\tFeatured in �Who is Who in Science and Engineering� in the 7th edition. \n8.\tMember of the Egyptian Fertility & Sterility Society. \n9.\tMember of the Egyptian Society of Ob./Gyn. \n10.\tMember of the Egyptian Society of Urogyn. \n\nScientific Publications & Communications:\n1- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Asim Kurjak, Ahmad G. Serour, Laila A. S. Mousa, Amr M. Zaied, Khalid Z. El Sheikha. \nImaging the Internal Urethral Sphincter and the Vagina in Normal Women and Women Suffering from Stress Urinary Incontinence and Vaginal Prolapse. Gynaecologia Et Perinatologia, Vol18, No 4; 169-286 October-December 2009.\n2- Abdel Karim M. El Hemaly*, Laila A. S. Mousa Ibrahim M. Kandil, Fatma S. El Sokkary, Ahmad G. Serour, Hossam Hussein.\nFecal Incontinence, A Novel Concept: The Role of the internal Anal sphincter (IAS) in defecation and fecal incontinence. Gynaecologia Et Perinatologia, Vol19, No 2; 79-85 April -June 2010.\n3- Abdel Karim M. El Hemaly*, Laila A. S. Mousa Ibrahim M. Kandil, Fatma S. El Sokkary, Ahmad G. Serour, Hossam Hussein.\nSurgical Treatment of Stress Urinary Incontinence, Fecal Incontinence and Vaginal Prolapse By A Novel Operation \n"Urethro-Ano-Vaginoplasty"\n Gynaecologia Et Perinatologia, Vol19, No 3; 129-188 July-September 2010.\n4- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Laila A. S. Mousa and Mohamad A.K.M.El Hemaly.\nUrethro-vaginoplasty, an innovated operation for the treatment of: Stress Urinary Incontinence (SUI), Detursor Overactivity (DO), Mixed Urinary Incontinence and Anterior Vaginal Wall Descent. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/ urethro-vaginoplasty_01\n\n5- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamed M. Radwan.\n Urethro-raphy a new technique for surgical management of Stress Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/\nnew-tech-urethro\n\n6- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamad A. Rizk, Nabil Abdel Maksoud H., Mohamad M. Radwan, Khalid Z. El Shieka, Mohamad A. K. M. El Hemaly, and Ahmad T. El Saban.\nUrethro-raphy The New Operation for the treatment of stress urinary incontinence, SUI, detrusor instability, DI, and mixed-type of urinary incontinence; short and long term results. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=urogyn/articles/\nurethroraphy-09280\n\n7-Abdel Karim M. El Hemaly, Ibrahim M Kandil, and Bahaa E. El Mohamady. Menopause, and Voiding troubles. \nhttp://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly03/el-hemaly03-ss\n\n8-El Hemaly AKMA, Mousa L.A. Micturition and Urinary\tContinence. Int J Gynecol Obstet 1996; 42: 291-2. \n\n9-Abdel Karim M. El Hemaly.\n Urinary incontinence in gynecology, a review article.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/abs-urinary_incotinence_gyn_ehemaly \n\n10-El Hemaly AKMA. Nocturnal Enuresis: Pathogenesis and Treatment. \nInt Urogynecol J Pelvic Floor Dysfunct 1998;9: 129-31.\n \n11-El Hemaly AKMA, Mousa L.A.E. Stress Urinary Incontinence, a New Concept. Eur J Obstet Gynecol Reprod Biol 1996; 68: 129-35. \n\n12- El Hemaly AKMA, Kandil I. M. Stress Urinary Incontinence SUI facts and fiction. Is SUI a puzzle?! http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly/el-hemaly-ss\n\n13-Abdel Karim El Hemaly, Nabil Abdel Maksoud, Laila A. Mousa, Ibrahim M. Kandil, Asem Anwar, M.A.K El Hemaly and Bahaa E. El Mohamady. \nEvidence based Facts on the Pathogenesis and Management of SUI. http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly02/el-hemaly02-ss\n\n14- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Mohamad A. Rizk and Mohamad A.K.M.El Hemaly.\n Urethro-plasty, a Novel Operation based on a New Concept, for the Treatment of Stress Urinary Incontinence, S.U.I., Detrusor Instability, D.I., and Mixed-type of Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/urethro-plasty_01\n\n15-Ibrahim M. Kandil, Abdel Karim M. El Hemaly, Mohamad M. Radwan: Ultrasonic Assessment of the Internal Urethral Sphincter in Stress Urinary Incontinence. The Internet Journal of Gynecology and Obstetrics. 2003. Volume 2 Number 1. \n\n\n16-Abdel Karim M. El Hemaly. Nocturnal Enureses: A Novel Concept on its pathogenesis and Treatment.\nhttp://www.obgyn.net/urogynecolgy/?page=articles/nocturnal_enuresis\n\n17- Abdel Karim M. El Hemaly. Nocturnal Enureses: An Update on the pathogenesis and Treatment.\nhttp://www.obgyn.net/urogynecology/?page=/ENHLIDH/PUBD/FEATURES/\nPresentations/ Nocturnal_Enuresis/nocturnal_enuresis\n\n18-Maternal Mortality in Egypt, a cry for help and attention. The Second International Conference of the African Society of Organization & Gestosis, 1998, 3rd Annual International Conference of Ob/Gyn Department � Sohag Faculty of Medicine University. Feb. 11-13. Luxor, Egypt. \n19-Postmenopausal Osteprosis. The 2nd annual conference of Health Insurance Organization on Family Planning and its role in primary health care. Zagaziz, Egypt, February 26-27, 1997, Center of Complementary Services for Maternity and childhood care. \n20-Laparoscopic Assisted vaginal hysterectomy. 10th International Annual Congress Modern Trends in Reproductive Techniques 23-24 March 1995. Alexandria, Egypt. \n21-Immunological Studies in Pre-eclamptic Toxaemia. Proceedings of 10th Annual Ain Shams Medical Congress. Cairo, Egypt, March 6-10, 1987. \n22-Socio-demographic factorse affecting acceptability of the long-acting contraceptive injections in a rural Egyptian community. Journal of Biosocial Science 29:305, 1987. \n23-Plasma fibronectin levels hypertension during pregnancy. The Journal of the Egypt. Soc. of Ob./Gyn. 13:1, 17-21, Jan. 1987. \n24-Effect of smoking on pregnancy. Journal of Egypt. Soc. of Ob./Gyn. 12:3, 111-121, Sept 1986. \n25-Socio-demographic aspects of nausea and vomiting in early pregnancy. Journal of the Egypt. Soc. of Ob./Gyn. 12:3, 35-42, Sept. 1986. \n26-Effect of intrapartum oxygen inhalation on maternofetal blood gases and pH. Journal of the Egypt. Soc. of Ob./Gyn. 12:3, 57-64, Sept. 1986. \n27-The effect of severe pre-eclampsia on serum transaminases. The Egypt. J. Med. Sci. 7(2): 479-485, 1986. \n28-A study of placental immunoreceptors in pre-eclampsia. The Egypt. J. Med. Sci. 7(2): 211-216, 1986. \n29-Serum human placental lactogen (hpl) in normal, toxaemic and diabetic pregnant women, during pregnancy and its relation to the outcome of pregnancy. Journal of the Egypt. Soc. of Ob./Gyn. 12:2, 11-23, May 1986. \n30-Pregnancy specific B1 Glycoprotein and free estriol in the serum of normal, toxaemic and diabetic pregnant women during pregnancy and after delivery. Journal of the Egypt. Soc. of Ob./Gyn. 12:1, 63-70, Jan. 1986. Also was accepted and presented at Xith World Congress of Gynecology and Obstetrics, Berlin (West), September 15-20, 1985. \n31-Pregnancy and labor in women over the age of forty years. Accepted and presented at Al-Azhar International Medical Conference, Cairo 28-31 Dec. 1985. \n32-Effect of Copper T intra-uterine device on cervico-vaginal flora. Int. J. Gynaecol. Obstet. 23:2, 153-156, April 1985. \n33-Factors affecting the occurrence of post-Caesarean section febrile morbidity. Population Sciences, 6, 139-149, 1985. \n34-Pre-eclamptic toxaemia and its relation to H.L.A. system. Population Sciences, 6, 131-139, 1985. \n35-The menstrual pattern and occurrence of pregnancy one year after discontinuation of Depo-medroxy progesterone acetate as a postpartum contraceptive. Population Sciences, 6, 105-111, 1985. \n36-The menstrual pattern and side effects of Depo-medroxy progesterone acetate as postpartum contraceptive. Population Sciences, 6, 97-105, 1985. \n37-Actinomyces in the vaginas of women with and without intrauterine contraceptive devices. Population Sciences, 6, 77-85, 1985. \n38-Comparative efficacy of ibuprofen and etamsylate in the treatment of I.U.D. menorrhagia. Population Sciences, 6, 63-77, 1985. \n39-Changes in cervical mucus copper and zinc in women using I.U.D.�s. Population Sciences, 6, 35-41, 1985. \n40-Histochemical study of the endometrium of infertile women. Egypt. J. Histol. 8(1) 63-66, 1985. \n41-Genital flora in pre- and post-menopausal women. Egypt. J. Med. Sci. 4(2), 165-172, 1983. \n42-Evaluation of the vaginal rugae and thickness in 8 different groups. Journal of the Egypt. Soc. of Ob./Gyn. 9:2, 101-114, May 1983. \n43-The effect of menopausal status and conjugated oestrogen therapy on serum cholesterol, triglycerides and electrophoretic lipoprotein patterns. Al-Azhar Medical Journal, 12:2, 113-119, April 1983. \n44-Laparoscopic ventrosuspension: A New Technique. Int. J. Gynaecol. Obstet., 20, 129-31, 1982. \n45-The laparoscope: A useful diagnostic tool in general surgery. Al-Azhar Medical Journal, 11:4, 397-401, Oct. 1982. \n46-The value of the laparoscope in the diagnosis of polycystic ovary. Al-Azhar Medical Journal, 11:2, 153-159, April 1982. \n47-An anaesthetic approach to the management of eclampsia. Ain Shams Medical Journal, accepted for publication 1981. \n48-Laparoscopy on patients with previous lower abdominal surgery. Fertility management edited by E. Osman and M. Wahba 1981. \n49-Heart diseases with pregnancy. Population Sciences, 11, 121-130, 1981. \n50-A study of the biosocial factors affecting perinatal mortality in an Egyptian maternity hospital. Population Sciences, 6, 71-90, 1981. \n51-Pregnancy Wastage. Journal of the Egypt. Soc. of Ob./Gyn. 11:3, 57-67, Sept. 1980. \n52-Analysis of maternal deaths in Egyptian maternity hospitals. Population Sciences, 1, 59-65, 1979. \nArticles published on OBGYN.net: \n1- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Laila A. S. Mousa and Mohamad A.K.M.El Hemaly.\nUrethro-vaginoplasty, an innovated operation for the treatment of: Stress Urinary Incontinence (SUI), Detursor Overactivity (DO), Mixed Urinary Incontinence and Anterior Vaginal Wall Descent. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/ urethro-vaginoplasty_01\n\n2- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamed M. Radwan.\n Urethro-raphy a new technique for surgical management of Stress Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/\nnew-tech-urethro\n\n3- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamad A. Rizk, Nabil Abdel Maksoud H., Mohamad M. Radwan, Khalid Z. El Shieka, Mohamad A. K. M. El Hemaly, and Ahmad T. El Saban.\nUrethro-raphy The New Operation for the treatment of stress urinary incontinence, SUI, detrusor instability, DI, and mixed-type of urinary incontinence; short and long term results. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=urogyn/articles/\nurethroraphy-09280\n\n4-Abdel Karim M. El Hemaly, Ibrahim M Kandil, and Bahaa E. El Mohamady. Menopause, and Voiding troubles. \nhttp://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly03/el-hemaly03-ss\n\n5-El Hemaly AKMA, Mousa L.A. Micturition and Urinary\tContinence. Int J Gynecol Obstet 1996; 42: 291-2. \n\n6-Abdel Karim M. El Hemaly.\n Urinary incontinence in gynecology, a review article.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/abs-urinary_incotinence_gyn_ehemaly \n\n7-El Hemaly AKMA. Nocturnal Enuresis: Pathogenesis and Treatment. \nInt Urogynecol J Pelvic Floor Dysfunct 1998;9: 129-31.\n \n8-El Hemaly AKMA, Mousa L.A.E. Stress Urinary Incontinence, a New Concept. Eur J Obstet Gynecol Reprod Biol 1996; 68: 129-35. \n\n9- El Hemaly AKMA, Kandil I. M. Stress Urinary Incontinence SUI facts and fiction. Is SUI a puzzle?! http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly/el-hemaly-ss\n\n10-Abdel Karim El Hemaly, Nabil Abdel Maksoud, Laila A. Mousa, Ibrahim M. Kandil, Asem Anwar, M.A.K El Hemaly and Bahaa E. El Mohamady. \nEvidence based Facts on the Pathogenesis and Management of SUI. http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly02/el-hemaly02-ss\n\n11- Abdel Karim M. El Hemaly*, Ibrahim M. 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