Human communication and interaction had been rapidly evolving with the advent and continuing influence of social media (SM) thereby accelerating information exchange and increasing global connectivity. Despite clear advantages, this new technology can present unintended consequences including medical misinformation and “fake news.” Although International Health Security (IHS) stands to benefit tremendously from various SM platforms, high-level decision-makers and other stakeholders must also be aware of the dangers related to its intentional and unintentional misuse (and abuse). An overview of SM utility in fighting disease, disseminating life-saving information, and organizing people and teams in a constructive fashion is discussed herein. The potential negatives associated with SM misuse, including intentional and unintentional misinformation, as well as the ability to organize people in a disruptive fashion, will also be presented. Our treatise will additionally outline how deliberate misinformation may lead to harmful behaviors, public health panics, and orchestrated patterns of distrust. In terms of both its affirmative and destructive considerations, SM can be viewed as an asymmetric influencing force, with observed effects (whether beneficial or harmful) being disproportionately greater than the cost of the intervention.