CAT CTV berthing limits for monopile various floater designs.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"2114",leadTitle:null,fullTitle:"Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications",title:"Advanced Gas Chromatography",subtitle:"Progress in Agricultural, Biomedical and Industrial Applications",reviewType:"peer-reviewed",abstract:"Progress in agricultural, biomedical and industrial applications' is a compilation of recent advances and developments in gas chromatography and its applications. The chapters cover various aspects of applications ranging from basic biological, biomedical applications to industrial applications. Book chapters analyze new developments in chromatographic columns, microextraction techniques, derivatisation techniques and pyrolysis techniques. The book also includes several aspects of basic chromatography techniques and is suitable for both young and advanced chromatographers. It includes some new developments in chromatography such as multidimensional chromatography, inverse chromatography and some discussions on two-dimensional chromatography. The topics covered include analysis of volatiles, toxicants, indoor air, petroleum hydrocarbons, organometallic compounds and natural products. The chapters were written by experts from various fields and clearly assisted by simple diagrams and tables. This book is highly recommended for chemists as well as non-chemists working in gas chromatography.",isbn:null,printIsbn:"978-953-51-0298-4",pdfIsbn:"978-953-51-4316-1",doi:"10.5772/2518",price:139,priceEur:155,priceUsd:179,slug:"advanced-gas-chromatography-progress-in-agricultural-biomedical-and-industrial-applications",numberOfPages:472,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"039ef2e529d905397d4775625fcc9ef5",bookSignature:"Mustafa Ali Mohd",publishedDate:"March 21st 2012",coverURL:"https://cdn.intechopen.com/books/images_new/2114.jpg",numberOfDownloads:213061,numberOfWosCitations:202,numberOfCrossrefCitations:77,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:219,numberOfDimensionsCitationsByBook:7,hasAltmetrics:1,numberOfTotalCitations:498,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 31st 2011",dateEndSecondStepPublish:"April 28th 2011",dateEndThirdStepPublish:"September 2nd 2011",dateEndFourthStepPublish:"October 2nd 2011",dateEndFifthStepPublish:"January 30th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"108777",title:"Dr.",name:"Mustafa",middleName:null,surname:"Ali Mohd",slug:"mustafa-ali-mohd",fullName:"Mustafa Ali Mohd",profilePictureURL:"https://mts.intechopen.com/storage/users/108777/images/3681_n.jpg",biography:"Mustafa Ali Mohd (PhD) is a professor in the Department of Pharmacology, Faculty of Medicine, University of Malaya, Malaysia. He has vast research and teaching experience in various fields, particularly in chromatographic and mass spectrometric techniques. Heis a member of editorial board of several scientific journals and he holds a position as advisory committee for several high level decision making bodies in food safety and quality, including as expert panel member in WHO expert meetings. Dr. Mustava Ali Mohd coordinates several international projects on analytical techniques such as GCMS and LCMS, and acts as the National project coordinator for the United Nations University Environmental Monitoring programme in East Asia region. His area of expertise includes endocrine disruptors research, clinical pharmacology, environmental monitoring, Natural products research, food safety and toxicology. He holds academic position as the Deputy Dean of the Faculty of Medicine, University of Malaya and currently the Deputy Director of the University of Malaya Medical Centre. 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Early devices were used to heat tissue prior to lipoaspiration, and the early cannulas performed both tissue heating and liposuction. Users gradually changed the order of the steps in the procedure, as it became clear that removing some of the adipose insulation prior to heating enhanced soft tissue contraction. Original versions of cannulas contained heating elements in a bipolar configuration that are allowed for treatment at multiple depths. A new, smaller version of radiofrequency was introduced in 2014. This device was monopolar and utilized a 10 or 15 cm wand-like cannula that was placed under the skin. Best suited for smaller areas, the device was capable of targeted nerve ablation as well as soft tissue coagulation. Both devices are considered “bulk heaters” as the subcutaneous cannula tip heats the soft tissue in gradients, hotter near the cannula tip and cooler away from the device tip [2]. The mechanism of action was the coagulation of the lax stromal collagen fibers, which resulted in overlying skin contraction as an indirect effect. In 2016, a helium plasma-driven radiofrequency device created for laparoscopic cutting and coagulation was used externally for skin resurfacing. An esthetic surgeon then placed the device under the skin, causing soft tissue coagulation and subsequent skin tightening in this region. Instead of targeting a large area of soft tissue, this device emits very small multidirectional pulses of RF energy that are impedance driven. The energy is delivered in a fractional manner. All subdermal RF devices cause mild soft tissue contraction initially, followed by gradual ingrowth of a new stromal collagen scaffold over time in the treated region. Safety is optimized with the helium plasma device, as the external skin temperature rarely reaches 39 degrees C. The treatment target is the fibroseptal stroma, not the overlying dermis.
Nanofat has been used for many purposes including enrichment of traditional fat grafts, in combination with myostimulation, and intradermal injection in patients who desire skin resurfacing without epidermal ablation. While the FDA considers nanofat or SVF produced with collagenase a drug, mechanical instead of chemical tissue manipulation does not fall into the “drug” or maximally manipulated category [3]. Mechanical devices must obtain a 510(k) clearance and are single use only. However, the individual devices cost quite a bit less per use than a tissue processing laboratory within the operating room would. Examples of nanofat processing units include the Nanocube (Lipocube, London) and Tulip devices (Tulip Medical, San Diego, CA). Nanofat is created from fatty lipoaspirate, and the cells that remain are fragile, prone to death when desiccated or roughly handled. The solution can be combined with particulate fat in order to enhance the quality of fat grafts. It can be injected intramuscularly following myostimulation. Nanofat can be injected into regions with radiation damage in order to lessen the deterioration of the skin and soft tissue. Also injected directly into the skin, nanofat can improve the quality of aging skin by stimulating dermal fibroblasts. It is not recommended to apply nanofat topically as very few cells will survive in this environment.
While either procedure alone has benefit, the combination of helium plasma-driven RF to treat soft tissue for localized volume reduction plus nanofat-enriched grafts for focal volumetric enhancement corrects most deformities in the subdermal region. The addition of intradermal nanofat injection helps to enhance the appearance of aging skin without creating any superficial injury.
Initially, the purpose of adding radiofrequency energy to traditional liposuction was to prevent the inevitable postoperative skin laxity in cases of moderate to large volume reduction. The Vectra measurement of skin surface area contraction [4] showed 26% surface area reduction at 6 weeks posttreatment and 36% at 1 year. Corresponding measurements of skin contraction obtained with mechanical stimulation after SAL showed contraction of 10% at 6 weeks and only 8% at 1 year. While laser-assisted liposuction did tighten the skin surface area more effectively than SAL at 13–17% measured skin tightening [5, 6], none of the other energy assists generated significant measured associated skin tightening. As patient expectations continue to grow, these also drive both technical and clinical development. Demands for a smooth, taut contour following treatment have encouraged surgeons to adopt techniques that will result in better outcomes than were common a decade ago. Changes that have been noted during this development phase include lower power settings, fewer passes—but passes at multiple depths—and more contouring in regions that need more attention. As with other energy-based devices, the RFAL procedure has evolved from a basic company guideline of three to five passes per region to more of a sculpting approach. Because most surgeons also perform excisional techniques, the ability to visualize which region needs 33% skin contraction or less is a good guideline for treatment. If there is a localized region with extreme pendulosity, skin excision might be recommended. In order to transition from simple skin tightening to directional shaping, both vision and experience help to guide the practitioner in the therapeutic application of RF energy.
The popularity of using nanofat has grown rapidly over the past several years. With FDA-cleared devices for mechanical production of progenitor cells, the process has become affordable for most physicians and patients. Nanocube TM has been cleared for mechanical adipose tissue processing. This device produces millifat, microfat, and nanofat. The harvested macrofat is serially transferred through a cutting screen. The cube is rotated between ports 1 and 2 to produce millifat. Microfat is produced following several passes through the screen between ports 2 and 3. Nanofat production requires passage of the adipose tissue through ports 3 and 4. There is an average of between 50,000 and 70,000 MSCs in each cc of this particular nanofat, though no adipocytes remain.
The Apyx Renuvion device has recently obtained a 510(k) clearance for a new handpiece that is significantly smaller in diameter than the original footprint (Figure 1). A bullet nose contour at the tip aids in a precise placement, and the two-side firing ports achieve a 360-degree directional energy placement. The handpieces are slightly flexible for ease of use in curved regions. As the energy is emitted just proximal to the handpiece tip, end hits are prevented. At a 3 mm diameter, instead of the previous 5 mm, the device can now be introduced through a small port created with a 16-gauge needle. Erythema and mechanical abrasion at the access port are reduced due to a graduated indicator system near the handpiece tip, warning the user that the device tip is near. More access points can now be placed without concern for pronged visible erythema. Also, more regions can be easily treated with the redesigned handpiece. The lower face, arms including the elbows, knees, and ankles are excellent targets for HPDRF treatment. There is no requirement for liposuction; soft tissue contraction in such areas as the neck, breast, arms, knees, and axilla can be performed following tumescent infusion.
New handpiece is approved by the FDA for soft tissue coagulation: side port configuration of tip—testing demonstrated that the first locations of highest external tissue temperatures were treatment transition areas (i.e., transitions from treated tissue to untreated areas) when energy was delivered distally from tip of the device. Based on the results of this testing, the APR handpiece was designed to have plasma discharged radially from the side ports of the tip as opposed to distally; indicator lines on tip of device—the second location where the external tissue temperatures were the highest was areas within approximately 40 mm from the incision site providing access to the subdermal plane. There is a risk of this area being overtreated since the treatment strokes of the device converge at the incision site. In order to prevent overtreatment of this area, indicator lines were included on the shaft of the Renuvion APR device to provide awareness to the user that the tip is nearing the incision site. The user is also instructed to stop activation of the device when the indicator line becomes visible at the incision site; and epidermal marking templates—provided in device packaging as a mean for the user to mark 40 mm from the incision site on the patient. This will prevent possible overtreatment where treatment passes converge at the incision site.
Optimal settings range from 60 to 80% power and 1.5 to 3 L/min helium flow rate. While a minimum of three passes per region is recommended for the average treatment region, thin areas such as the nonfatty neck, upper arms, decollette, and knees should be treated with no more than two passes per region in order to avoid postoperative fibrosis.
While general anesthesia reduces the need for large volumes of tumescent fluid infusion, small areas can be treated under local anesthesia. Patients may find that the inhalation of nitrous oxide can reduce perceived discomfort during tumescent infusion. The limitations of local/ tumescent anesthesia include possible lidocaine toxicity and increased sensitivity to discomfort when the second region is being treated.
Following sterile prep and draping, access ports that were pre-marked in the upright position are injected with local anesthetic. A small 20-gauge infusion cannula is used to infuse standard Klein’s solution into the treatment region at multiple levels. The recommended fluid ratio is 1:1, meaning that approximately 1 cc of lipoaspirate is planned for each cc of tumescent infused. Because helium plasma RF is impedance driven, too little fluid creates a high-resistance field, while too much fluid does not allow the tissues to heat optimally. Liposuction is performed prior to RF heating in cases where it is indicated. If no liposuction is performed, pre-tunneling with a 3 mm cannula is recommended in order to establish the proper planes prior to application of RF energy. It is strongly recommended that at least three communicating access ports be created, so that helium gas is allowed to escape. Postoperative crepitus can be reduced by aspirating from each access port following RF heating. Three to five passes are recommended in each treatment region if the area is moderately lipodystrophic. In patients with very thick fat layers, up to eight passes can be performed at multiple varying depths. It is possible to create a seroma if depths are not varied. If energy is applied only superficially, the lax adipose layer will not reattach to the underlying fascia, and an optimal correction will not be achieved. It is important not to scrape the underside of the skin in an effort to achieve skin contraction. This can cause linear depressions that are very difficult to correct. Recommendations to stay at least 5 mm under the base of the dermis will improve the possibility of a smooth skin surface postoperatively. When performing a secondary case, marking of any preoperative depressions in the standing position is ideal. Following any revisional liposuction of the protruding areas, any treatment with RF heating should remain at the Scarpa’s fascia or below in order to avoid creating more superficial fibrosis. After the use of RF heat, fat grafting should be performed with slight overcorrection in the depressed regions. Specific regional contouring descriptions are given below.
Nanofat was processed following the harvest of fat using traditional liposuction techniques with negative pressure of only 10 mm Hg. In order to reduce extravasated free fatty acid contents, filtration rather than centrifugation was used for initial fat processing. Macrofat (particles measuring >3 mm) was then processed in the Nanocube in order to produce millifat, microfat, and nanofat (Figure 2). Macrofat was injected in regions needing more structure, such as the bra roll depression, chin, and the prejowl sulcus. Millifat was injected in the infraorbital hollows in order to avoid lumpiness. Microfat can be injected with a 25-gauge needle and is used for supporting the deep dermis or for mixing with biostimulatory agents such as hydroxyapatite.
(a) Macrofat: Best for structural repair and contains stroma and fat >2 mm particle size. (b) Millifat: Obtained with first pass through Nanocube. 2 mm particle size. (c) Microfat: Obtained with second pass through Nanocube. Able to inject into the dermis. (d) Nanofat: This solution has progenitor cells but no adipose and can inject intradermally with a 30-gauge needle.
Nanofat can be combined with all types of particulate fat and also can be injected by itself with a 30-gauge needle. The stimulation of dermal fibroblasts is the primary purpose with superficial nanofat injection.
The combination of using helium-driven plasma in the subcutaneous space for contouring has been enhanced with the development of a new handpiece. Ease of use, especially in areas with thin skin, striae, and small surface areas, has made the operative procedure more straightforward. Due to the slightly flexible nature of the cannula, directional shaping in regions such as the jawline, neck, lateral breast and axilla, upper arm, and knees has become possible.
The use of Renuvion is no longer limited to skin surface area contraction, though this use is off-label. The ability to shape soft tissue is difficult, even with traditional surgical techniques. If the fibroseptal network can be manipulated in such a way that a new form with defined shape is possible without skin excision, the stage is set for optimized outcomes.
The addition of fat grafting in certain regions also enhances results. For example, many women have skin pendulosity as well as localized lipodystrophy in the bra roll region. Frequently, there is an associated depression, due to the tethering of the dermis to the midlevel Scarpa’s fascia. By releasing the tether and creating a superficial subdermal tunnel that is then filled with transferred fat, the deformity can be fully corrected without surgical skin excision (Figure 3).
(a) 38-year-old before surgery. (b) 3 months post-Renuvion treatment of bra roll and flanks.
Other areas that benefit from this combination are the lower face and jawline. A common problem with aging is bony resorption of the maxilla and mandible. This process causes visible jowling due to skin and stromal laxity as well as hollowing of the prejowl sulcus and gonial notch. The process of soft tissue aging is characterized by gradual loss of the scaffold, or fibroseptal network, in the fatty layer (Figure 4). The use of radiofrequency energy in the multiple levels of adipose stroma will regenerate this framework over the period of 1 year.
(a) SEM of aging adipose tissue. Note the lack of collagen support network. (b) 3 months post-RF treatment of the adipose layer; the collagen binding network is restored.
Hollow regions tend to be focal instead of diffuse. Known regions of accelerated aging include the prejowl sulcus, gonial notch, oral commissures, distal nasolabial folds, and medial infraorbital regions. Temporal hollowing, also known as the “old horse” phenomenon, also creates an aged appearance even in younger patients. By restoring the smooth and full contour of the face and jawline, apparent age reduction can be accomplished with a process known as microlifting [7].
A third novel use of combined RF energy plus nanofat-enriched grafting is in male body contouring. Formerly reserved for liposuction plus etching [8], the addition of myostimulation plus fat transfer to the male contouring armamentarium has broadened the scope of male body contouring. By combining electromagnetic energy [9] with stem cell tissue enrichment, muscle volume can be enhanced in ways not achievable in the gym. Figure 5 shows results of a man treated 2 years ago with Renuvion and his 2-year result.
(a) 38-year-old before surgery. (b) Early result 6 weeks post-op. (c) Result at 2 years post-op.
Myostimulation with radiofrequency energy combined with nanofat injection can also enhance the small muscles of the face. As we age, the combination of bone atrophy, muscle thinning and atrophy, and soft tissue volume loss [10] can lead to the development of a negative facial expression [11]. The combination of RF myostimulation at subcoagulative levels combined with intramuscular injection of progenitor cells can result in shortening of the long, attenuated upper lip by 3 mm or more without a “bullhorn” skin excision (Figure 6). The addition of erbium laser resurfacing can definitively optimize the long-term outcome in patients ≥60 years of age. In patients with mild to moderate neck laxity, the use of plasma-driven radiofrequency in the neck and submental region can be an alternative to a surgical neck lift, even with patients over 60 (Figure 7).
(Above) 73-year-old woman before surgery. (Below) 6 months post-laser resurfacing, fat grafting, and RF myostimulation to the upper lip.
(Above) 61-year-old before treatment. (Below) Same patient 3 months post-Renuvion-assisted neck lift. No skin was excised.
Regenerative medicine is rapidly gaining a large market share of the esthetic market [12]. The procedures that utilize the patient’s own tissues make sense to most people, and the ability to generate a prolonged improvement without significant temporary deformity or downtime resonates with potential customers. As the popularity of minimally invasive or noninvasive procedures soars [13], esthetic practices are enthusiastically seeking solutions that are safe and effective. By understanding the causes of apparent aging as well as minimally or noninvasive options for skin and soft tissue restoration, esthetic practitioners are able to address these concerns in ways that patients identify with. The optimal combination of electromagnetic and RF energy plus nanofat-enriched fat transfer can optimize long-term outcomes of rejuvenative procedures.
The use of subdermal RF energy can restore the framework or scaffold that supports the overlying skin. With commonly used liposuction techniques, especially superficial liposuction, the integrity of that framework can be compromised, and a cannula defect or localized depression can result. Even with subdermal radiofrequency devices, if the cannula is used to scrape the underside of the dermis, interrupting the subdermal fibroseptal network, the adjacent soft tissue contraction will paradoxically amplify the defect as the soft tissue near the injury contracts. A uniform network of contractile hypodermis is needed for a smooth postoperative surface.
The combination of subcutaneous tissue contraction and stabilization and regeneration of the overlying skin will provide the optimal outcome in most facial and body contouring efforts. If underlying muscle laxity is a contributing factor to the deformity, electromagnetic stimulation of the affected muscle is recommended. Restoration of the stromal/skin complex’s attachment to the underlying fascia can be achieved by applying RF energy at the junction of these two layers. Figure 8 shows a patient treated with plasma-driven RF in the abdominal region. Treatment of the lower diastasis can improve the midline gap up to 5 cm. This is a minimally invasive alternative to an abdominoplasty in suitable patients.
(a) 35-year-old mom with diastasis recti. She declined abdominoplasty. (b) 3 months post-Renuvion-assisted liposuction. Significant improvement of her rectus diastasis was obtained.
Care must be taken to not overtreat here in the abdominal region, as a seroma can develop. Overtreatment can also cause fibrosis which can compromise the gliding of the skin surface.
The use of fat grafting in facial, neck, and body contouring is well established [14]. Coleman is considered the father of fat grafting, popularizing the technique in the early 1990s [15]. He notes that the range of “take” of the fat grafts can range from 10 to 90% [16], depending on the technique and postoperative compliance of the recipient. The enhancement of graft take can be achieved by avoiding large-volume injections, by stratifying the fat injections at multiple levels, and by pulsing small volumes at a time so that a “string of pearls” effect is achieved. If there is a significant component of liquefied fat in the injectable fat, this will reduce graft take. The traumatized fat or desiccated fat is less viable than the fat harvested at low pressure and kept in a closed container. A current common practice is the topical application of nanofat following nonthermal microneedling, RF microneedling, or fractional laser resurfacing. There is little uptake of progenitor cells with these methods, as the aDSCs are prone to desiccation and traumatic death. A recent publication [17] advocates the use of a biocreme to enhance cell viability. Future development of the novel use of nanofat for skin enhancement will no doubt optimize the technique so that consistent outcomes can be achieved.
An interesting use of nanofat is the injection of the substance intradermally. Figure 9 shows a patient treated in the infraorbital region using this method. Since the particulate size is very small, the solution can be injected with a 30-gauge needle. The effect of intradermal nanofat improves with time, so that outcomes at 1-year post-injection are much more remarkable than early changes [18]. Regions that can be significantly improved with intradermal nanofat include the upper lip and the infraorbital region. By adding nanofat to the traditional macrofat grafts, the outcomes, especially in facial regions, are enhanced. By milling macrofat into millifat, lumpiness in regions with skin can be reduced.
(a) 58-year-old before treatment. (b) 3 months following laser resurfacing, fat grafting, and intradermal injection of nanofat.
Regenerative medicine has become a popular antiaging resource that patients are actively seeking. Helium plasma-driven fractional radiofrequency energy can restore the lost fibroseptal scaffold in many regions of the face, neck, and body. While FSN contraction can reconstruct a framework of cohesive fatty stroma upon which the skin can rest, aged skin will not be appreciably improved as it is not directly addressed. Instead of using damaging resurfacing techniques such as laser ablation or thermal microneedling, the regenerative restoration of dermal fibroblasts as well as the generation of a new blood supply helps to thicken the dermis as well as improve the tone, texture, and wrinkles. Little downtime is seen with the use of nanofat injections, and there is very little temporary deformity. The addition of nanofat to traditional fat for grafting enhances both structural and vascular response. As with most esthetic procedures, combination therapy is superior to the use of a single modality when an optimal outcome is desired. The use of helium plasma-driven radiofrequency energy for soft tissue contouring and skin tightening is an excellent approach for the restoration of the supportive fibroseptal network. Nanofat plus more traditional approaches can optimize the correction of volume deficiencies as well as the correction of thin, structurally deficient skin. As research and development of both of these techniques evolves, biological restoration of the aging soft tissues is predicted to become more popular than other surgical or injectable approaches.
The development of floating wind farms implies the issue of offshore O and M workers safety. It is therefore of upmost importance to know the constraints and acceptable conditions for berthing a CTV.
For berthing with the “bump and jump” method, a CTV comes and pushes its fender against the boat landing ladder. The fender studied here is the stiff fender [1].
The present work relies on the results of a study performed by HSVA [2] and endeavors to meet the results obtained in its CTV model tank test. However, our approach here is different from HSVA numerical berthing calculations, which are more sophisticated.
The calculation is based on a simplified linear diffraction-radiation model applied in the frequential domain [1].
The studied ship is a CATamaran CTV (CAT CTV) [2, 3]: 27 m long, 8.2 m wide, twin hulls 3.2 m wide. It is modelled with Wigley hulls (Figure 1) [1].
CTV berthing against monopile (3D view).
The software used are GMSH for meshing [4] and NEMOH for hydrodynamics [5].
The Wigley hull, due to the wave excitation, moves in a vertical plane as follows (Figure 2) [1]:
1 rotation against her floatation centre | 1 degree of freedom | θ (pitch) |
1 translation against her original position O | 2 degrees of freedom | τx (surge) τz (heave) |
CTV sea keeping without berthing (elevation).
The equations of dynamics are:
Fexcit: vector of wave loads Ia: matrix of added inertia (both calculated by NEMOH [5]) | |
(calculated with NEMOH [5]) | |
P = propeller thrust. If: |
The friction coefficient without sliding is, about the principle of action and reaction (Figure 3) [1]:
Coulomb’s friction law.
Assumptions:
A thrust P is added to N, in order never to reach N < 0:
For a low friction berthing:
The equations at the berthing point A = A- become therefore:
We define tT and tN respectively as the time phase corrections required to get the calculated loads T(t) and N(t) in phase with HSVA test results THSVA (t) and NHSVA (t) [2].
We also define the following notations:
In order for the function f(t) to get relative extremes, the numerator of the quotient in Eq. (8) must have a positive discriminant δ′:
Moreover, the denominator in Eq. (8) must never be null. Physically that means that the CTV propeller thrust P should be great enough in order never to get N < 0. Mathematically that implies both that its discriminant Δ′ must be negative and that
If the conditions (3) and (4) are met, then, over a wave period, the friction coefficient will reach its extremes at the instants t+ and t−, which correspond to the following values T+ and T−:
Then the maximum friction coefficient over a wave period is:
We must therefore choose. Physically, that is the CTV surge over which the CTV captain has the time to adjust the propeller thrust P, in order for the fender never to lose contact with the boat landing. Nevertheless, the CTV is limited by her maximum thrust Pmax. We infer that:
Or, in other words:
The selected criterion for CTV boarding at the berthing point is that the friction coefficient must never exceed the grip factor:
For benchmarking purpose, the first calculation models the “bump and jump” against a monopile (Figures 1 and 4). The water depth is 29 m.
CTV berthing against monopile (plane view).
The studied monopile has a 5 m diameter [2].
It may be noted that the CAT CTV is wider than the monopile: therefore the former is not masked from the waves by the latter.
Figure 5 compares for 2 m significant wave height (Hs) the calculated ratio of wave vertical force over wave horizontal force (T/N) with the grip coefficient of rubber against very wet soil (fgrip) [6].
Curves T/N and fgrip versus wavelength over boat length for 2 m Hs.
For comparison reference [7] estimates the berthing limit to be for a ratio wavelength over boat length of 1.85 (λ/B): both results meet with 5% accuracy.
The second calculation models the “bump and jump” against a planned [8] cylindrical wind turbine floater (Figures 6 and 7). The water depth is 70 m [8].
CTV berthing against 13 m diameter cylindrical floater (3D view).
CTV berthing against 13 m diameter cylindrical floater (plane view).
The studied cylinder has [8]: a 13 m diameter, 14 m draft, 2000 T displacement.
This time, the floater masks the CAT CTV from the incidental waves, therefore the horizontal incident wave loads are masked, while the vertical incident wave loads are only the ones passing below the floater keel.
Figure 8 compares for 2 m Hs the calculated ratio T/N with fgrip versus λ/B.
Curves T/N and fgrip versus λ/B for 2 m Hs.
This time berthing may take place for 2 m Hs whatever the wavelength.
The third calculation models the “bump and jump” against a cylindrical wind turbine floater (Figures 9 and 10). The water depth is 23 m.
CTV berthing against 41 m diameter cylindrical floater (3D view).
CTV berthing against 13 m diameter cylindrical floater (plane view).
The studied cylinder has: a 41 m diameter, 7 m draft, 9300 T displacement.
One more time, the floater masks the CAT CTV from the incidental waves, therefore the horizontal incident wave loads are masked, while the vertical incident wave loads are only the ones passing below the floater keel.
Figure 11 compares for 2 m Hs the calculated ratio T/N with fgrip versus λ/B.
Curves T/N and fgrip versus λ/B for 2 m Hs.
This time berthing may take place for 2 m Hs whatever the wavelength.
The fourth calculation models the “bump and jump” against a parallelepipedal wind turbine floater (Figures 12 and 13). The water depth is 23 m.
CTV berthing against 36 m side parallelepipedal floater (3D view).
CTV berthing against 36 m side parallelepipedal floater (plane view).
The studied cylinder has: a 36 m sides, 7 m draft, 9300 T displacement (same draft and displacement as in Section 5).
One more time, the floater masks the CAT CTV from the incidental waves, therefore the horizontal incident wave loads are masked, while the vertical incident wave loads are only the ones passing below the floater keel.
Figure 14 compares for 2 m Hs the calculated ratio T/N with fgrip versus λ/B.
Curves T/N and fgrip versus λ/B for 2 m Hs.
This time berthing may take place for 2 m Hs whatever the wavelength.
The fifth calculation models the “bump and jump” against an existing [9] square hollow floater (Figures 15 and 16). The water depth is 23 m [10].
CTV berthing against FLOATGEN floater (elevation).
CTV berthing against FLOATGEN floater (plane view).
The studied square has [9, 10]: 36 m side, 7 m draft, 6000 T displacement (same draft as in Sections 5 and 6).
Once again, the floater masks the CAT CTV from the incidental waves, therefore the horizontal incident wave loads are masked, while the vertical incident wave loads are only the ones passing below the floater keel.
Figure 17 compares for 2 m Hs the calculated ratio T/N with fgrip versus λ/B.
Curves T/N and fgrip versus λ/B for 2 m Hs.
One more time berthing may take place for 2 m Hs whatever the wavelength.
Table 1 sums up the Hs found for berthing to occur whatever the wavelength.
Case | Floater geometry | Depth | Maximum Hs for berthing |
---|---|---|---|
1 | 5 m diameter monopile | 23 m | 1.5 m (no masking) |
2 | 13 m diameter cylindrical floater | 70 m | 2.1 m |
3 | 41 m diameter cylindrical floater1 | 23 m | 2.5 m |
4 | 36 m side square floater1 | 23 m | 2.6 m |
5 | 36 m side square hollow floater (FLOATGEN) | 23 m | 2.3 m |
CAT CTV berthing limits for monopile various floater designs.
Those floaters have been chosen to have same displacement and draft.
FLOATGEN 2.3 m Hs berthing limit calculations compare precisely with feedback from offshore site test with full scale prototype [11]:
“Transfer up to 2.3 m significant wave height with no motion compensation”.
From Table 1, it may be noted that berthing limits are influenced by:
Hardly by floater geometry if they have the same displacement.
Significantly by their displacement: the greater the displacement, the greater the berthing limit.
It is possible to propose an approximative analytical of the berthing limit due to the floater masking effect. Indeed, the calculated ratio T/N is (see Eq. (8)):
where:
At the large wave periods we have the following behavior:
Where (see Eq. (11)):
In the case of box barge of same displacement, length and draft, we have:
Note: since the vertical incident wave loads are only the ones passing below the floater keel then, if its draft is |z0|, zm/a = zm(z = z0) = sinh[k(z0 + h)]/sinh(kh) [12] (refer to equations written in Figures 6,9,12, and 15).
Therefore:
Therefore:
Eventually, we get the following formula for berthing to possible [1]:
Table 2 sums up the analytical Hs found for berthing to occur whatever the wavelength, by using Eq. (29).
Case | Floater geometry | Depth | Maximum Hs for berthing (Hs = 2a)1 |
---|---|---|---|
1 | 5 m diameter monopile | 23 m | 1.5 m (no masking) |
2 | 13 m diameter cylindrical floater | 70 m | 2.0 m |
3 | 41 m diameter cylindrical floater | 23 m | 2.3 m |
4 | 36 m side square floater | 23 m | 2.3 m |
5 | 36 m side square hollow floater (FLOATGEN) | 23 m | 2.3 m |
CAT CTV analytical berthing limits for monopile various floater designs.
The CAT CTV fender length is L = 1 m [1].
As can be seen results from Tables 1 and 2 meet with less than 12% discrepancy. The reason why is that the analytical calculation does not account for the diffraction forces.
Eventually, some practical considerations must be accounted for (see Figure 18):
Floater wave masking performances (cylinder versus FLOATGEN).
The more the wave direction varies, the more a large floater width becomes necessary to allow berthing by masking the waves.
The present study results find that berthing a CTV against an offshore wind turbine is not yet optimized, at least from a marine maintenance point of view: most designs do not provide sheltered waters.
Some proposals focus on improving the CTV:
ESNA promote the use of Surface Effect Ships (SES), to minimize their heave. However, the lack of commercial success of the solution seems related to the high fuel consumption of such boats [7].
Other proposals focus rather on the floater side:
IDEOL have designed a pontoon-like floater which provides sheltered waters. At best that solution will prove successful for floating wind farms. Obviously, that is not a solution for fixed wind farms [11].
FLOATING POWER POINT propose a floating wind turbine combined with a wave energy convertor (WEC), to provide an artificial harbor downstream, thanks to the wave energy extracted by the WEC [13].
Another possible axis of development would be to design an additional wall to existing boat landings, providing a sheltered water.
Eventually, since the present study only applies to a unidirectional wave, the next studies will focus on multidirectional waves, in order represent a more realistic sea state.
The author gratefully acknowledges the support from ENSM and its director of research and industrial relations, Mr. Dominique FOLLUT, for throughout the present research work.
Cat | Catamaran |
CTV | crew transfer vessel |
DP | dynamic positioning |
Hs | significant wave height |
HSVA | Hamburgische Schiffbau-Versuchsanstalt GmbH (Hamburg Ship Model Tank Test Facilities) |
O&M | operation & maintenance |
RAO’s | response amplitude operators |
3D | three dimensional |
2D | two dimensional |
WT | wind turbine |
O, x, y, z | absolute reference frame |
M | operating point fixed to the CTV |
ρ | water specific gravity |
h | water depth |
B | ship length |
H | ship draft |
m (or Δ) | ship mass (or displacement) |
G | ship centre of gravity |
IG | ship inertia at G |
C | ship centre of buoyancy |
I | matrix of ship own inertia |
Ia | matrix of ship added inertia |
K | matrix of stiffnesses |
B | matrix of dampings |
Fexcit | vector of wave loads |
λ | wavelength |
A- | berthing point |
O, X, Y, Z | reference frame attached to the ship |
F | centre of floatation |
g | gravitational acceleration |
xG, zG | coordinates of ship gravity centre |
xC, zC | coordinates of ship buoyancy centre |
b3 | ship heave damping factor |
k3 | ship vertical hydrostatic stiffness |
Cd | shipdrag coefficient |
Cm1 | added mass coefficient in x direction |
ma | added mass in x direction |
X | vector of ship motions |
τx | ship surge |
τz | ship heave |
θ | ship pitch angle |
T | regular wave period |
k | wave number |
a | wave amplitude (half crest to through) |
x (or bc) | flat rate heave damping coefficient (%-age of critical damping) |
xmax or τxm | max. surge estimate (for quadratic damping force) |
ω | wave pulsation |
θmax | adimensional max. pitch estimate (for quadratic damping force) |
Λ | 4ρCCdxmax+Hθmax/3π |
cΛ | ΛH/m+ma |
G | CTV surge over which the CTV captain has the time to adjust the propeller thrust P, in order for the fender never to lose contact with the boat landing |
xm | max. CTV surge |
zm | max. CTV heave |
θm | max. CTV pitch |
φx | max. CTV surge |
φz | max. CTV heave |
φθ | max. CTV pitch |
L | fender length |
Za+ | CTV propeller elevation |
Z0 | floater keel elevation |
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Most previous works focused on only one of the external quality parameters, such as color, size, mass, shape, and defects. In this work, we proposed an integrated machine vision system that can grade, sort, and classify mangoes using multiple features including weight, size, and external defects. We found that weight estimation using our proposed algorithm based on visual information was not statistically different from that of a conventional weight measurement using a static digital load cell; the estimation error is relatively small (4–5%). We also constructed an artificial neural network model to classify mango having multiple types of external defect; the classification error is less than 8% for the worst possible case. The results indicate that our system shows a great potential to be used in a real industrial setting. Future work will aim to investigate other features such as ripeness and bruises to increase the effectiveness and practicality of the system.",book:{id:"7270",slug:"agricultural-robots-fundamentals-and-applications",title:"Agricultural Robots",fullTitle:"Agricultural Robots - Fundamentals and Applications"},signatures:"Son V.T. Dao",authors:[{id:"252669",title:"Dr.",name:"Vu Truong Son",middleName:null,surname:"Dao",slug:"vu-truong-son-dao",fullName:"Vu Truong Son Dao"}]},{id:"62785",title:"Hybrid-Powered Autonomous Robots for Reducing Both Fuel Consumption and Pollution in Precision Agriculture Tasks",slug:"hybrid-powered-autonomous-robots-for-reducing-both-fuel-consumption-and-pollution-in-precision-agric",totalDownloads:1052,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Environmental contamination and the resulting climate change are major concerns worldwide. Agricultural vehicles that use fossil fuels emit significant amounts of atmospheric pollutants. Thus, this study investigates techniques to reduce fuel consumption in robotic vehicles used for agricultural tasks and therefore reduce atmospheric emissions from these automated systems. A hybrid energy system for autonomous robots devoted to weed and pest control in agriculture is modeled and evaluated, and its exhaust emissions are compared with those of an internal combustion engine-powered system. Agricultural implements require power for hydraulic pumps and fans; this energy is conventionally provided by power take-off (PTO) systems, which waste substantial amounts of energy. In this work, we examine a solution by designing and assessing a hybrid energy system that omits the alternators from the original vehicle and modifies the agricultural implements to replace the PTO power with electrical power. The hybrid energy system uses the original combustion engine of the tractor in combination with a new electrical energy system based on a hydrogen fuel cell. We analyze and compare the exhaust gases resulting from the use of (1) an internal combustion engine as the single power source and (2) the hybrid energy system. The results demonstrate that the hybrid energy system reduced emissions by up to approximately 50%.",book:{id:"7270",slug:"agricultural-robots-fundamentals-and-applications",title:"Agricultural Robots",fullTitle:"Agricultural Robots - Fundamentals and Applications"},signatures:"Mariano Gonzalez-de-Soto, Luis Emmi and Pablo Gonzalez-de-Santos",authors:[{id:"252783",title:"Prof.",name:"Pablo",middleName:null,surname:"Gonzalez-De-Santos",slug:"pablo-gonzalez-de-santos",fullName:"Pablo Gonzalez-De-Santos"},{id:"252784",title:"Dr.",name:"Mariano",middleName:null,surname:"Gonzalez-De-Soto",slug:"mariano-gonzalez-de-soto",fullName:"Mariano Gonzalez-De-Soto"},{id:"252785",title:"Dr.",name:"Luis",middleName:null,surname:"Emmi",slug:"luis-emmi",fullName:"Luis Emmi"}]},{id:"62821",title:"An Evaluation of Three Different Infield Navigation Algorithms",slug:"an-evaluation-of-three-different-infield-navigation-algorithms",totalDownloads:1116,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"In this chapter, we present and evaluate three different infield navigation algorithms, based on the readings from a LIDAR sensor. All three algorithms are tested on a small field robot and used to autonomously drive the robot between the two adjacent rows of maze plants. The first algorithm is the simplest one and just takes distance readings from the left and right side. If robot is not in the center of the mid-row space, it adjusts its course by turning the robot in the right direction accordingly. The second approach groups the left and right readings into two vertical lines by using least-square fit approach. According to the calculated distance and orientation to both lines, it adjusts the course of the robot. The third approach tries to fit an optimal triangle between the robot and the plants, revealing the most optimal one. Based on its shape, the course of the robot is adjusted. All three algorithms are tested in a simulated (ROS stage) and then in an outdoor (maze test field) environment comparing the optimal line with the actual calculated position of the robot. The tests prove that all three approaches work with an error of 0.041 ± 0.034 m for the first algorithm, 0.07 ± 0.059 m for the second, and 0.078 ± 0.055 m error for the third.",book:{id:"7270",slug:"agricultural-robots-fundamentals-and-applications",title:"Agricultural Robots",fullTitle:"Agricultural Robots - Fundamentals and Applications"},signatures:"Peter Bernad, Peter Lepej, Črtomir Rozman, Karmen Pažek and Jurij Rakun",authors:[{id:"179642",title:"Prof.",name:"Karmen",middleName:null,surname:"Pažek",slug:"karmen-pazek",fullName:"Karmen Pažek"},{id:"188886",title:"Prof.",name:"Črtomir",middleName:null,surname:"Rozman",slug:"crtomir-rozman",fullName:"Črtomir Rozman"},{id:"255090",title:"Dr.",name:"Jurij",middleName:null,surname:"Rakun",slug:"jurij-rakun",fullName:"Jurij Rakun"},{id:"255091",title:"Dr.",name:"Peter",middleName:null,surname:"Lepej",slug:"peter-lepej",fullName:"Peter Lepej"},{id:"255092",title:"BSc.",name:"Peter",middleName:null,surname:"Bernard",slug:"peter-bernard",fullName:"Peter Bernard"}]}],onlineFirstChaptersFilter:{topicId:"1283",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"1",title:"Oral Health",coverUrl:"https://cdn.intechopen.com/series_topics/covers/1.jpg",isOpenForSubmission:!0,editor:{id:"173955",title:"Prof.",name:"Sandra",middleName:null,surname:"Marinho",slug:"sandra-marinho",fullName:"Sandra Marinho",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGYMQA4/Profile_Picture_2022-06-01T13:22:41.png",biography:"Dr. Sandra A. Marinho is an Associate Professor and Brazilian researcher at the State University of Paraíba (Universidade Estadual da Paraíba- UEPB), Campus VIII, located in Araruna, state of Paraíba since 2011. She holds a degree in Dentistry from the Federal University of Alfenas (UNIFAL), while her specialization and professional improvement in Stomatology took place at Hospital Heliopolis (São Paulo, SP). Her qualifications are: a specialist in Dental Imaging and Radiology, Master in Dentistry (Periodontics) from the University of São Paulo (FORP-USP, Ribeirão Preto, SP), and Doctor (Ph.D.) in Dentistry (Stomatology Clinic) from Hospital São Lucas of the Pontifical Catholic University of Rio Grande do Sul (HSL-PUCRS, Porto Alegre, RS). She held a postdoctoral internship at the Federal University from Jequitinhonha and Mucuri Valleys (UFVJM, Diamantina, MG). She is currently a member of the Brazilian Society for Dental Research (SBPqO) and the Brazilian Society of Stomatology and Pathology (SOBEP). Dr. Marinho's experience in Dentistry mainly covers the following subjects: oral diagnosis, oral radiology; oral medicine; lesions and oral infections; oral pathology, laser therapy and epidemiological studies.",institutionString:null,institution:{name:"State University of Paraíba",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null},{id:"2",title:"Prosthodontics and Implant Dentistry",coverUrl:"https://cdn.intechopen.com/series_topics/covers/2.jpg",isOpenForSubmission:!0,editor:{id:"179568",title:"Associate Prof.",name:"Wen Lin",middleName:null,surname:"Chai",slug:"wen-lin-chai",fullName:"Wen Lin Chai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHGAQA4/Profile_Picture_2022-05-23T14:31:12.png",biography:"Professor Dr. Chai Wen Lin is currently a lecturer at the Department of Restorative Dentistry, Faculty of Dentistry of the University of Malaya. She obtained a Master of Dental Science in 2006 and a Ph.D. in 2011. Her Ph.D. research work on the soft tissue-implant interface at the University of Sheffield has yielded several important publications in the key implant journals. She was awarded an Excellent Exchange Award by the University of Sheffield which gave her the opportunity to work at the famous Faculty of Dentistry of the University of Gothenburg, Sweden, under the tutelage of Prof. Peter Thomsen. In 2016, she was appointed as a visiting scholar at UCLA, USA, with attachment in Hospital Dentistry, and involvement in research work related to zirconia implant. In 2016, her contribution to dentistry was recognized by the Royal College of Surgeon of Edinburgh with her being awarded a Fellowship in Dental Surgery. She has authored numerous papers published both in local and international journals. She was the Editor of the Malaysian Dental Journal for several years. Her main research interests are implant-soft tissue interface, zirconia implant, photofunctionalization, 3D-oral mucosal model and pulpal regeneration.",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},editorTwo:{id:"479686",title:"Dr.",name:"Ghee Seong",middleName:null,surname:"Lim",slug:"ghee-seong-lim",fullName:"Ghee Seong Lim",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003ScjLZQAZ/Profile_Picture_2022-06-08T14:17:06.png",biography:"Assoc. Prof Dr. Lim Ghee Seong graduated with a Bachelor of Dental Surgery from University of Malaya, Kuala Lumpur in 2008. He then pursued his Master in Clinical Dentistry, specializing in Restorative Dentistry at Newcastle University, Newcastle, UK, where he graduated with distinction. He has also been awarded the International Training Fellowship (Restorative Dentistry) from the Royal College of Surgeons. His passion for teaching then led him to join the faculty of dentistry at University Malaya and he has since became a valuable lecturer and clinical specialist in the Department of Restorative Dentistry. He is currently the removable prosthodontic undergraduate year 3 coordinator, head of the undergraduate module on occlusion and a member of the multidisciplinary team for the TMD clinic. He has previous membership in the British Society for Restorative Dentistry, the Malaysian Association of Aesthetic Dentistry and he is currently a lifetime member of the Malaysian Association for Prosthodontics. Currently, he is also the examiner for the Restorative Specialty Membership Examinations, Royal College of Surgeons, England. He has authored and co-authored handful of both local and international journal articles. His main interest is in prosthodontics, dental material, TMD and regenerative dentistry.",institutionString:null,institution:{name:"University of Malaya",institutionURL:null,country:{name:"Malaysia"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:54,paginationItems:[{id:"81595",title:"Prosthetic Concepts in Dental Implantology",doi:"10.5772/intechopen.104725",signatures:"Ivica Pelivan",slug:"prosthetic-concepts-in-dental-implantology",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Concepts in Dental Implantology - From Science to Clinical Research",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80963",title:"Pain Perception in Patients Treated with Ligating/Self-Ligating Brackets versus Patients Treated with Aligners",doi:"10.5772/intechopen.102796",signatures:"Farid Bourzgui, Rania Fastani, Salwa Khairat, Samir Diouny, Mohamed El Had, Zineb Serhier and Mohamed Bennani Othmani",slug:"pain-perception-in-patients-treated-with-ligating-self-ligating-brackets-versus-patients-treated-wit",totalDownloads:21,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Current Trends in Orthodontics",coverURL:"https://cdn.intechopen.com/books/images_new/10780.jpg",subseries:{id:"2",title:"Prosthodontics and Implant Dentistry"}}},{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:35,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. 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She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}]},{type:"book",id:"7139",title:"Current Approaches in Orthodontics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7139.jpg",slug:"current-approaches-in-orthodontics",publishedDate:"April 10th 2019",editedByType:"Edited by",bookSignature:"Belma Işık Aslan and Fatma Deniz Uzuner",hash:"2c77384eeb748cf05a898d65b9dcb48a",volumeInSeries:2,fullTitle:"Current Approaches in Orthodontics",editors:[{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null}]},{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",slug:"trauma-in-dentistry",publishedDate:"July 3rd 2019",editedByType:"Edited by",bookSignature:"Serdar Gözler",hash:"7cb94732cfb315f8d1e70ebf500eb8a9",volumeInSeries:3,fullTitle:"Trauma in Dentistry",editors:[{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",institutionURL:null,country:{name:"Turkey"}}}]},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. 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That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"25",type:"subseries",title:"Evolutionary Computation",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11421,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",slug:"elmer-p.-dadios",fullName:"Elmer P. 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