For the past three decades since the dawn of the concept of scaling down fluidic processes and systems, various microfabrication techniques have been significantly explored and developed. Glass and elastomers, as first-generation microfluidic device materials, are still widely used, while other alternatives have emerged. We have seen a rise in novel and innovative device designs and fabrication in droplet microfluidics which enable easier and more cost-effective approach of generating droplets, such as the use of commercially available “off-the-shelf” components, plug-and-play modular devices, and 3D-printed droplet generators. This chapter aims to review some of these facile approaches for droplet generation and discuss the versatility and functionability of these designs for possible commercial formulations. Discussions of rationales for and challenges of the development of these conceptual devices are included.