Chapters authored
Hemostatic Aspect of Sepsis
The hemostatic system is composed of primary hemostasis and coagulation on the one hand, and natural regulatory anticoagulant protein mechanisms and fibrinolysis, on the other hand. Under physiological conditions, these processes are balanced. Under septic conditions, coagulopathy may followed by disseminated intravascular coagulation (DIC). Tissue factor (TF) pathway is regarded to be the core way for activation of the coagulation cascade in sepsis. TF is triggered by pro-inflammatory mediators, encompassing cytokines, C-reactive protein, and advanced glycation end products in peripheral blood cells and on microparticle molecules. Once a septic patient develops DIC, a significant increase in the susceptibility of developing organ dysfunction, morbidity, and mortality may occur. This work was basic elucidation of the idea that coagulation and its inhibitors are of major importance in coagulation-inflammation noise, similarly as in cure from sepsis.
Part of the book: Infectious Process and Sepsis