Aquaculture continues to be the fastest-growing food production field that has a lot of potential to meet the aqua-protein needs. The scientific and business communities are responding to the many challenges and opportunities inherent in the growing aquaculture field. Advancements in production and detection of harmful material systems and technologies are contributing to aquaculture industry’s expansion and sustainability. All of these production system technologies are benefitting from expanding information and communication systems, which are enabling advances in every stage of production. In the future, the new farming operation of friendly environment will focus on the use of nonecology destructive substances, no antibiotics, and the natural probiotics or novel immunomodulatory substances to match the physiological regulation of cultured organisms and the management of aquaculture. The future scientific-based innovation will contribute toward meeting increasing food demands, while improving social, environmental, and financial sustainability of the global aquaculture industry.