\r\n\tOne basic topic is that of expression manipulation: combining, expanding etc, and the applications of this scholar topic needs focusing on.
\r\n
\r\n\tThe general topic of "polynomials" is very large, and here the focus is both on scholar/student basics of it, and on applications of some special polynomials in science and research.
\r\n
\r\n\tAn important topic of the book is "algebraic curve". Here the approaches are multiple: basic/scholar on one hand, and applications on the other hand. It must be noticed the use of algebraic curves properties in the field of differential equations, for example for finding the singularities.
\r\n
\r\n\tGrobner basis is a very modern and applied topic of algebra. Here we must outline the great importance of Grobner basis and polynomial ideals manipulation, in the differential equations field, an example being in fast finding normal forms of differential systems.
\r\n
\r\n\tRelated to this last topic of the book, but applying to all specified topics, it must be noticed the importance of numeric algorithms. The importance of software algorithms in all fields of science is continuously increasing. Therefore, computational approach of the specified algebraic topics is very useful, with applications in other mathematical and scientific fields.
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She received her PhD degree from the Polytechnic University of Bucharest, Romania. Her research focuses on development and implementation of new methods in the qualitative and computational analysis of differential equations and their applications. This includes constructing adequate models for approaching the study of different industrial phenomena from a dynamical system standpoint and also from a computational fluid dynamics standpoint. By its optimizing techniques, the aim of the modeling is to facilitate the high understanding of the experimental phenomena and to implement new methods, techniques, and processes. Currently, Dr. Ionescu is working in developing new analytical techniques for linearizing nonlinear dynamical systems, with subsequent applications in experimental cases. The bifurcation theory and its applications in related fields is also a domain of interest for her. She has published six monographs and few scientific papers in high-impact journals. 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1. Introduction
Herpes zoster (HZ) is an infection of dorsal root ganglion characterized by a painful cutaneous rash. It is believed that reactivated varicella zoster virus (VZV) migrate from dorsal root ganglion in retrograde direction along the sensory nerve to the skin, where it makes the characteristic dermatomal rash [1].
The initial infection caused by varicella or chickenpox occurs during childhood. After that, the virus then exists as a latent infection of sensory ganglia from which it may reactivate many years later and cause herpes zoster.
The virus can be recovered from skin lesion and can cause an inflammatory reaction in sensory ganglion, dorsal root, and posterior horn of spinal cord [2].
Postherpetic neuralgia is the most common complication associated with extracranial HZ. Pain persisting 90 days or longer after the onset of the shingles rash is called postherpetic neuralgia [3, 4]. Postherpetic neuralgia usually remits spontaneously, but some patients could have pain for all their life.
Beside postherpetic neuralgia, segmental herpetic paresis is another complication of HZ, and they often occur together.
Flaccid muscle paralysis rarely occurs due to the spread of the infection from the posterior horn of spinal cord to the anterior horn and the motor nerve root (Figure 1) when weakness generally corresponding to the dermatomes in which cutaneous lesions develop [5].
Figure 1.
Origin of segmental zoster paresis: the spread of varicella zoster infection from the posterior horn of spinal cord to the anterior horn and the motor nerve root.
This finding supports the enhancement of spinal nerve roots on MRI that was clinically symptomatic [6], attributed to autoimmune inflammation or vasculitis [7]; brachial plexus inflammation; and myelin destruction with intact axons found postmortem [8].
The association of muscle paralysis and herpes zoster was first reported by Broadbent in 1866. When he described the case to zoster described as “frozen shoulder” [9], it is noted rarely between 0.5% [10] and 0.8% of segmental motor paralysis between all patients with HZ [11].
In patients with dissociation between motor and dermatomal involvement, a possible explanation could be viral spread to anterior roots without corresponding axonal transport through the sensory nerves [6, 12].
Some patients may have zoster infection without vesicular eruptions, which is called “zoster sine herpete.” This diagnose is safer by a rise VZV antibodies. These patients may have the same neurologic manifestations, including muscular paralysis [13].
As there are no certain standards regarding diagnosis and treatment of segment zoster paresis, we have listed in this paper experiences from literature related to the topic.
The aim of this study was to summarize the experiences related to its clinical manifestation, applied diagnostics, treatment, and patient outcome.
2. Methods
We searched the PubMed database for literature on herpes zoster infection and extracranial motor paresis in adults (last search on September 2019).The search was limited to full-length articles written in English and a study population that included adults aged 18 years and older. A combination of the following search terms was used “herpes zoster, paresis, complications.” As a result, 74 articles were retrieved.
The reference list was also searched for relevant manuscripts not retrieved from PubMed.
Studies included in the final review met the following criteria: (1) infection with herpes zoster virus, (2) motor paresis, and (3) adult study population.
They encompass original articles, technical reports, clinical observations, and single case reports.
3. Results
3.1 Data extraction and synthesis
For comparison across the reports, the sample size was extracted along with demographic information (gender and age), clinical presentation, laboratory confirmation of herpes zoster, electromyographic (EMG) findings, imagining, treatment, and course.
For clarity, segmental zoster paresis is classified into several categories: paresis of upper extremity, lower limb involvement, diaphragmatic involvement, and abdomen involvement.
Upper extremity involvement: In 37 previously published papers about patients with segmental zoster paresis of arms, there are 19 papers that are processed only as arms paresis (Table 1), while the rest of the 18 papers describe patients with segmental zoster paresis of arms and legs (Table 2). They include a total of 101 patients with segmental paresis of arms with a mean age of 68.56 ± 11.97 and with 55 women and 45 men and one patient who did not specify gender.
Burning pain and rash in the left shoulder and its weakness
Hyperalgesia skin in left C4–T2 dermatomes, left shoulder abduction weakness
EMG-denervation in left biceps, deltoid, brachioradialis and C5–6 paraspinal muscles; sensory and motor nerve-conduction, and somatosensory evoked potentials are normal
MRI of cervical spine-degenerative changes with foraminal stenosis at C3–T1
750 mg/d famciclovir per os, cervical epidural blocks with 20 mg triamcinolone twice during 4 weeks, 450 mg pregabalin and 10 mg nortriptyline, physiotherapy
After 2 months, pain and weakness were significantly retracted
15 patients (9 females and 6 males, mean age 66 years, range 48–80) with rheumatoid arthritis in 3, lymphosarcoma in 1, and lymphatic leukemia in 1
Pain-to-rash interval 2–3 days in 5 patients, 4–6 days in 6, 7 days in 2, unknown in 2; Rash-to-weakness interval < 10 days in 1 patient, 10 to 28 days in 12, 42 days in 1, unknown in 1 (similar in upper and lower limbs)
Distribution of motor paresis: C5–6 in 5, C5–7 in 1, C7-C8-T1 in 2; L3-S1 in 7, L3-S1. Weakness severe in 10 patients, moderate in 3, mild in 2; sensory abnormalities in half of the patients; reflexes diminished
Denervation in 12 patients
Increased protein and cell count in CSF of one patient
Not reported
Full recovery in 11 patients (5 arms and 6 legs). Mean recovery time in arms 9 months, 7 months in legs. 2 improved arms and 1 in legs. Postherpetic neuralgia in 3 patients
61 patients (39 men and 22 women), mean age 62 yrs. (range 18–87); lymphoma in 6, chronic lymphocytic leukemia in 1, diabetes in 3, histoplasmosis in 1
Rash-to-weakness interval in 51 patients: <3 days in 6, 3–6 days in 12, 7–10 days in 14, 11–14 days in 11, 15–20 days in 5, 21–28 days in 2 patients, 29–35 days in 1
Weakness in upper limbs in 16 (C5 to T1 segments at about equal frequency), lower limbs in 15 patients (L2 to S1 at about similar frequency); abdominal weakness in 2 patients
EMG in 18 patients (9 of them are within legs): fibrillations present in all affected muscles, MUAPs decreased in number in 2 with large amplitudes; sensory and motor nerve conduction studies normal in all but 3 cases
CSF proteins and cell count increased in 2 patients
Not reported
Limb recovery full in 55%, marked in 25%; residual pain in 8 patients (4 of them are with leg distribution)
Rash of the right foot and a right L5-S1 plexopathy
Weakness in right L5-S1 myotomes
No recovery after 1.8 years
#4. 80–90-year old with DM
Rash in neck first
After 22 days right C8 myotome weakness
Denervation in right plexus brachialis
No recovery after 1.9 years
#5. 87-year old male with DM
Rash in right lateral arm and forearm
After 14 days right C6–8 myotome weakness
Denervation in right C6–8 distribution
Increased signal in the C6–8 nerve roots
No recovery 1.0 year
#6. 60-70-year (nn gender)
Rash in right buttocks and lateral calf
Weakness in right L5 myotome
Right L5 radiculoplexopathy with denervation
Partial recovery after 1.0 year
#7. 61-year old male
Rash in left thumb, index finger and forearm
After 15 days weakness in left C6–8 myotomes
Left C7 radiculopathy with denervation
Increased signal in median and radial nerve on MRI
No recovery after 0.5 year
#8. 80-year old female
Rash in right shoulder, anterolateral arm and thumb
Weakness in right C5 myotomes
Denervation in right C5 distribution
Increased signal in the C5 nerve roots on MRI
Partial recovery after 0.5 year
Table 2.
Lists of studies that reviewed herpes zoster infection and motor paresis of arms and legs.
There are few comorbidities in this population of patients: 2 patients with carcinoma mammae, 7 patients suffering from lymphoma, 4 were taking corticosteroids due to autoimmune diseases (2 patients with rheumatoid arthritis, 1 with polymyalgia rheumatica, and 1 with myasthenia gravis), and 4 of them were diabetic.
Clinically, segmental zoster paresis is usually unilateral paresis of arm, predominantly on the right side (42/26, 33 cases do not specify the affected side).
Proximal muscles were affected in most cases (in 52 patients), while the entire arm [40] or only distal muscles [41] were significantly less affected.
Besides weakness, in 9 patients, muscle atrophy was detected.
Phrenic nerve affection followed by dyspnea was observed in 6 patients.
Electromyoneurography was performed in 58 patients, and denervation potential has been described in most cases (51 patients), often associated with reduced pattern and polyphasia of motor unit potentials in most cases (17 patients). Reduced motor or sensor velocity was seen in 4 patients. In some cases, neurophysiological finding was only descriptive: “lesion of nerve,” “acute motor axonal lesion,” and “severe median and ulnar nerve neuropathy.”
Another test was performed in only small number of patients: neck MRI (unremarkable in 2 patients, foraminal stenosis in 1, and protruded disk in 1) and MRI of the affected arm in 1 patient with enlargement of T2 signal of the median nerve.
X-ray of the shoulder was performed in 2 patients (1 patient showed subluxation) and 2 X-rays of the neck (1 unremarkable and 1 with spondyloarthrosis) and 2 X-rays of the chest with 1 showing elevated hemidiaphragm and paralysis confirmed by following fluoroscopy were performed.
Standard laboratory in 2 patients was unremarkable; positive sera antibody test for HZ was found in 3 patients.
Hyperproteinorachia was found in 2 patients and normal CSF was found in 1 patient among patients with lumbar puncture.
In 1 patient, surgical exploration was done and it was without compression.
In almost all cases with a mentioned type of treatment were treated with physical therapy (24 reported patients). Some of them had other therapies: Valacyclovir 3 g/7 days (3 patients), Acyclovir 750 mg/7 days (2 patients iv and 1 per os); and Methylprednisolone 500 mg iv for 3 days (1 patient), and some of them were taking steroids [11], cervical epidural bloc [11], analgesics [42], opioids [43], Amitriptyline [43], Pregabalin [11], and Gabapentin [11].
Most reported patients recovered significantly: complete or near complete recovering is recorded in 8 patients that are reported during following periods: 3 weeks, 1 month, 2 months, 3 months, 6 months, and 2 years. Incomplete recovery was reported in 3 patients, minimal recovery in 1 patient after 2 months, and no recovery after 8 months in 1 patient. One patient recovered from weakness after 5 months but with persisted neuralgia.
3.1.1 Lower limb involvement
There are 43 presented patients with isolated segmental zoster paresis of one leg in the total of 26 previously published papers. Nine of these papers present only zoster paresis of the lower limbs, while the rest of them describe affection of arms and torso, also. According to available information, mean age of this group of patients was 64.19 ± 15.28, and the patient group was dominated by males (20/12).
From medical history, these patients had: diabetes mellitus (4 patients), lymphatic leukemia [11], ulcerative colitis [11], myelofibrosis [11], renal failure [11], hypertension arterialis [43], dementia [11], restless legs syndrome, and chronic low back pain [11].
Almost all patients had weakness in one leg; but 3 of them developed weakness in both legs.
In most cases, proximal muscles were affected (in 13 patients); then in much lesser number, distal muscles (6 patients) were affected; and only 4 of them had developed entire limb weakness.
Muscle atrophy was seen in 3 patients in this group (in M. quadriceps).
With regard to other complications, 2 patients developed incontinency, 1 urinary retention, 1 ileus, and 2 abdominal wall weakness.
Denervation has been the most common report (in 18 patients) among patients with electromyoneurography performed; reduced interference pattern was found in 12 patients and polyphasia was present in 4 patients.
Laboratory is sporadically performed in these patients: ELISA for HZV in sera done in 2 patients and were positive in IgG and IgM fraction in both of them, and in the third patient, performed VZV complement fixation was positive, also.
A lumbar puncture was done in a small number of patients [44, 45]: cerebrospinal fluid (CSF) was normal in two cases, but in the other three patients, hyperproteinorachia was discovered.
The patient with flaccid paraparesis had elevated lymphocytes and hyperproteinorachia in cerebrospinal fluid, while PCR for VZV was positive in this case.
MRI of lumbar spine performed in 4 patients did not explain the nature of deficit in these patients, and 2 patients were generally described by degenerative changes, 1 was normal, and in 1 enlargement and T2 signal in the left femoral nerve was found.
The most frequent treatments were physical therapy (4 patients), Acyclovir (2 patients), Methylprednisolone (2 patients), vitamins B1 and B12 [11], paravertebral sympathetic block [11], analgesics, and Gabapentin, lately [11].
There is no information about outcome of the disease for some patients. However, among patients who were followed for a period of time, a majority of them (20 patients) fully or almost fully recovered in the period between 2 and 9 months; 11 patients recovered incompletely; 2 patients did not recover, and 2 patients had with lethal outcome.
3.1.2 Diaphragmatic paralysis
Diaphragmatic paralysis due to phrenic nerve involvement with VZV is described in 24 previously published papers with a total of 26 patients with a mean age of 67.13 ± 11.50 years.
Among comorbidities in this population of patients are rheumatoid arthritis [11], leukemia [11], breast cancer [11], pyelonephritis and nephrectomy, hysterectomy [11], DM [11], hypertension [43], peptic ulcer [11], pancreatitis [11], and bypass [11].
Hemidiaphragmatic paresis is unilateral usually, predominantly on the left side [46], while in one patient, hemidiaphragmatic affection on both sides were recorded.
Although EMNG of phrenic nerve is one of the reliable signs of affection in this nerve, it is rarely performed (1 patient). More often, fluoroscopy is performed when weakness of the diaphragm is suspected (7 patients). Although not a reliable sign of weakness of the diaphragm, X-ray is often done in the case of a suspected weakness of the diaphragm paresis (13 patients).
Phrenic nerve affection is usually followed by dyspnea, but there is a case with hemidiaphragmatic paresis on X-ray, but without visible dyspnea.
To the contrary, there are cases with normal hemidiaphragm position on non-CT chest, when dyspnea is present clinically.
Half of the patients [47] did not recover after significant a follow-up period (1 year and more). Partial recovery was seen in significantly smaller number of patients [48], while complete recovery was present in the fewest number of patients [42].
In most cases, the type of treatment of these patients was not mentioned: Acyclovir in 2 patients, Valacyclovir in 1 patient, physical therapy in 1 patient, and topical hydrocortisone in 1 patient.
The incidence of segmental zoster abdominal paresis mimicking an abdominal hernia is relatively rare. After review from 2013 [49] with 36 patients and segmental zoster paresis of abdominal muscle (14), 8 papers with 11 patients with this problem have been published.
Their mean age (66.5 years) is not much different from the average age of the patients in the review paper from 2013 (67.5 years).
As in the review paper, the predominant level of abdominal involvement of herpes zoster was Th11.
It is the most important to exclude organic disease of the abdomen in the case of abdominal herniation when beneficial are ultrasound or CT abdomen showing normal results.
This is particularly relevant when the abdominal herniation is complicated with, for example, ileus, which is described in 1 patient.
The presence of denervation potentials in EMG of paraspinal (3 patients), or abdominal muscles (2 patients), indicates the involvement of the abdominal musculature, which separates EMG as well as a particularly useful diagnostic method in this case.
Prognosis of these patients is generally good, and there is full recovery in almost all of them in just few months [42, 43, 50].
Acyclovir is rarely used as a therapy in these patients (2 patients).
4. Discussion
Increasing rate of herpes zoster infection with increasing age particularly after age 50 years can be explained by natural decline in cell-mediated immunity to VZV with age [51]: the mean age of patients with the most frequent segmental paresis was for arms 68.56 ± 11.97 years and for legs 64.19 ± 15.28 years.
Healthy people can get HZ [31], although immunocompromised individuals are known to be at increased risk of reactivation and VZV infection [52].
The most immunocompromised patients with zoster paresis have a coexisting malignancy, diabetes mellitus, and chronic steroid therapy [53]: 7 patients suffering from lymphoma and 2 with carcinoma mammae in group with arm segmental paresis and 1 patient with segmental paresis of leg had lymphatic leukemia; as per 4 patient in each group and 1 in group with diaphragmatic paresis suffered from DM and as per 4 patient in both groups of patients with limb segmental paresis on chronic steroid therapy because of autoimmune disorders.
In clinical presentation of HZ infection, pain usually precedes the onset of the rash, and most patients have skin lesions that develop within 7 days of onset of pain [32].
Motor palsy is usually segmental, with abrupt onset reaching its maximum within a few hours [31], corresponding to the dermatomes with cutaneous lesions [18]. Interval between skin eruptions and onset of muscle weakness is generally about 2 weeks in cases with developing segmental paresis [54], but there are some reports of weakness and rash developing simultaneously [55]. With reference to the literature, maximal rash-to-weakness interval in patients with segmental limb paresis was 19 days [37] although there are different experiences. Variations in rash-to-weakness interval is best illustrated in a study of 51 patients: <3 days in 6 patients, 3–6 days in 12, 7–10 days in 14, 11–14 days in 11, 15–20 days in 5, 21–28 days in 2, and 29–35 days in 1 [33]. A delay of 4.5 months has been documented in a patient with diaphragmatic paralysis [56], when the average minimum duration of weakness was 193 days [57]. The fact that the phrenicus nerve is a motor nerve and is the longest in the body is the explanation for such a long period of time required for the development of paralysis of phrenic nerve.
Limb involvement by segmental zoster paresis is seen from 0.5 to 0.8% of all patients with cutaneous zoster [10, 11].
Upper extremity involvement is the most common region of extracranial zoster paresis involvement. There are a total of 101 patients with segmental paresis of upper limbs in recently published papers: 55 women and 45 men (Tables 1 and 3).
Burning pain along the inner aspect of the right lower leg (6/10) and rash, weakness of the right foot
Weakness of the right ankle plantar flexors (3/5 on MRC scale) and diminished ankle jerk
Fibrillations and positive sharp waves in the right gastrocnemius and paravertebral muscles (S1 root); polyphasic MUAP during activation of right foot, nerve conduction was unchanged
MRI of lumbosacral area: degenerative changes; ELISA test on VZV in sera positive for IgM and IgG
Physical therapy and oral gabapentin 900 mg/day
Motor weakness completely resolved about 6 months after the onset of neurologic symptoms but the pain was sporadic but mild
37-year old-female with history of paresis in both legs secondary to spinal cord atrophy and Vogt-Koyanagi-Harada disease and with chronic corticosteroid and azathioprine treatment of ulcerative colitis
Worsening of her baseline residual muscle strength in the right lower limb shortly after herpes zoster eruption
EMG: denervation in L3-L4 and moderate axonal polyneuropathy affecting both lower limbs
Table 3.
Lists of studies that reviewed herpes zoster infection and motor paresis of only lower limbs.
Segmental zoster paresis of the legs present in less than half the number (43 patients with leg involvement) dominated by males (20/12) (Tables 2 and 3).
Phrenic nerve affection was described in 26 patients (Table 4).
Rash on right neck and apper right hemithorax C3-5
hiccups
On X-ray paralysis of the right hemidiaphragm, HIV +
intravenous acyclovir and admitted to the hospital
Table 4.
Lists of studies that reviewed herpes zoster infection and motor paresis of diaphragmatic paralysis.
Among patients with limb paresis, proximal muscle involvement usually predominates (C5, 6, 7 or L2, 3, 4). The most commonly affected muscle is deltoid in upper limbs [78].
Besides weakness in upper limbs affected by segmental zoster paresis, in 9 patients, muscle atrophy was detected and in 3 patients in group had leg affection (in M. quadriceps).
It is important to recognize severe muscle weakness and atrophy in herpes zoster paresis of limb because it can be so severe to cause marked dislocation of the joint. Because of that, except pain medication, treatment for segmental paresis includes exercise that may prevent muscle atrophy and contractures [17].
Risk of postherpetic neuralgia and pain after 3 months of HZ infection increased and occurs in 8–70% of patients with HZ. People above 50 years are 15 times more likely to develop this complication [79].
In studies involving a larger number of patients with segmental zoster paresis, postherpetic neuralgia persisted in 2 and 6.6% [32, 33].
Among the patients monitored over several months and multiyear period, 13 patients with segmental zoster paresis of arm and 6 patients with paresis of leg have reported pain as the postherpetic neuralgia type (Tables 1–3).
The clinical diagnosis makes pain followed by rash and by weakness at the end. Once the rash appears, diagnosis of HZ can be made and laboratory confirmation is not always required.
Some patients may have zoster sine herpete, and it is zoster infection without vesicular eruptions. In making this diagnosis benefit is from varicella zoster virus antibodies in sera or cerebrospinal fluid [13]. In rare cases with herpes sine herpete, cases with prolonged period between rash and muscular weakness and cases with dissociation between motor segment and level of dermatomal involvement recommended laboratory confirmation of VZV infection because herpes zoster paresis may be difficult to recognize in these cases.
Possible explanation for zoster sine herpete and for herpes zoster paresis without associated dermatome eruption could be viral spread to anterior roots without corresponding axonal transport through the sensory nerve [6, 12].
Electrophysiologic study of segmental zoster paresis found reinnervation of muscles, absence of fasciculations in involved muscles, and slow motor nerve conduction velocity suggesting motor axon injury rather than anterior horn cells [80].
In electromyoneurography of 58 patients with arm paresis, denervation potential has been described in most cases (51 patients), often associated with reduced pattern and polyphasia of motor unit potentials in most cases (17 patients) and reduced motor or sensor velocity in 4 patients.
Denervation has been the most common report (in 18 patients) among patients who had electromyoneurography of leg paresis; reduced interference pattern in 12 patients and polyphasia in 4 patients were present.
Although EMNG of phrenic nerve is one of the reliable signs of affection in this nerve, it is rarely performed (1 patient).
The presence of denervation potentials in electromyography of paraspinal (3 patients), or in abdominal muscles (2 patients), indicates involvement of the abdominal musculature, which separates EMG as well as a particularly useful diagnostic method in case of abdominal wall zoster paresis (Table 5). Because of its self-limited nature and good prognosis, recognition of this complication is important to prevent unnecessary diagnostic studies and procedures, and because of that, abdominal hernia needs no surgery. Thus, electrodiagnostic studies can be effectively used to confirm the diagnosis.
35 articles that described 36 individuals; mean age was 67.5 years. The ratio of men to women was 4:1.
The most affected dermatome was with rash is T11. The left and right sides were approximately equally affected
In 88.9% of the patients, herpetic rash preceded abdominal weakness. The mean latent period from rash to onset of abdominal muscle weakness was 3.5 weeks.
Electrodiagnostic studies confirmed the diagnosis in 95% of tested patients.
Conservative measures
Complete recovery with conservative measures occurred in 79.3% patients, with a mean time of 4.9 months
Bulge on his left flank 2 weeks after cutaneous changes
Table 5.
Lists of studies that reviewed herpes zoster infection and motor paresis of abdominal wall.
The treatment for segmental zoster paresis includes physical therapy for weakened muscles and protection contractures with graduated exercise. This program may prevent muscle atrophy. Muscle weakness and atrophy can be so severe to cause marked dislocation of the involved joint [17].
In segmental paresis of arm, in most cases, a way of treating these patients is not mentioned. In others, physical therapy was the most common way of treating these patients (24 reported patients) and patients with leg affection, also (4 patients).
Beside physical therapy, for these patients, it is often necessary to provide pain medication, and therefore they are usually given analgesics, opioids, Amitriptyline, Pregabalin, and Gabapentin.
According to some recommendations, initiating treatment with antiviral agents as soon as the rash appears is the key to improve the outcome of herpes zoster. A 3-week course of oral corticosteroids (prednisone 60 mg/day for first week, 30 mg/day for second week, and 15 mg/day for third week) administered with the antiviral medication also has some effect on severity and duration of pain and may decrease the incidence of postherpetic neuralgia [87]. Local, epidural, and sympathetic blocks, if administered within the first 2 weeks of disease, have been reported to decrease pain and the incidence of postherpetic neuralgia [88, 89].
Initiating treatment with antiviral agents as soon as the rash appears is the key to improve the outcome of herpes zoster. As the effect of this therapy on the development of segmental paresis is not known, despite such recommendations, it appears that very small number of patients from the literature with segmental zoster paresis was treated with antiviral medication and corticosteroids. Among the antiviral drugs, Valacyclovir and Acyclovir (in total 13 patients) and corticosteroids in total 5 patients were usually used.
Previous experience in groups with a higher number of patients with segmental zoster paresis shows that the outcome of lower motor neuron involvement is relatively good [55]. Motor paralysis is recovered completely or nearly completely in 50–70% of cases usually within 12 months, spontaneously [11]. The time of recovery varies from 1 to 2 years [90]. Only 15% have significant deficit [33].
Among presented patients with known clinical outcomes, complete or near complete recovery is recorded in 9 patients with arm involvement and in 20 patients with leg affection.
Incomplete recovery was reported in 3 patients with arm affection and in 11 patients with leg affection (Tables 1–3). Two patients from each group, with segmental paresis of arms and legs, had no clinical recovery. As possible explanation of absence of a complete recovery after motor segmental paralysis caused by herpes zoster is glial scar polyradiculitis evident on MRI [91].
Prognosis in patients with diaphragmatic paralysis is not good because of prolonged reinnervation of diaphragm due to relatively long course of phrenic nerve affection, and the lack of spontaneous recovery is not surprising [74]. It is common for zoster phrenic nerve affection and associated diaphragmatic paralysis to be permanent, but occasionally, recovery has been reported after 7 and 12 months [92].
There are interesting experiences related to Piramat. It may reverse phrenic nerve paralysis in patients with diabetes, but there are no data about its use in patients with zoster-induced diaphragmatic paralysis [90].
It is important to distinguish segmental zoster paresis of abdominal wall from real abdominal wall hernia because abdominal wall hernia is mainly treated by surgery, while segmental zoster abdominal paresis needs no surgery. Ultrasonography or computed tomography (CT) is necessary to do in this case. Electromyographic testing revealed denervation in the affected dermatome and pseudohernia caused by abdominal wall paresis and is of great benefit in defining the problem and recommended in these situations.
5. Conclusion
Segmental zoster paresis is a rare complication of VZV infection. Increasing rate of herpes zoster infection and its segmental paresis is confirmed by the mean age of presented patients‑it is above 65 years.
Recognizing segmental zoster paresis is important in the differential diagnosis of muscle weakness of other origin—it is of particular importance to perform electromyoneurography of paretic muscle.
Physical therapy is the most common therapy for these patients, although a lot of patients did not conducted any specific way of treatment.
Prognosis for these patients is generally good, and there is full recovery in most cases, except VZV infection of phrenic nerve and diaphragmatic paresis, where there is no significant recovery of muscle weakness in significant number of patients.
\n',keywords:"segmental paresis, varicella zoster, clinical presentation, diagnosis, treatment, course",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/71254.pdf",chapterXML:"https://mts.intechopen.com/source/xml/71254.xml",downloadPdfUrl:"/chapter/pdf-download/71254",previewPdfUrl:"/chapter/pdf-preview/71254",totalDownloads:243,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,dateSubmitted:"July 19th 2019",dateReviewed:"November 14th 2019",datePrePublished:null,datePublished:"April 1st 2020",dateFinished:"February 27th 2020",readingETA:"0",abstract:"Segmental zoster paresis (SZP) is a rare complication of varicella zoster infection that occurs due to the spread of the infection from the posterior horn of spinal cord to the anterior horn and the motor nerve root. As recognizing segmental zoster paresis is important in the differential diagnosis of muscle weakness of other origin, information about demographic (gender and age), clinical presentation, diagnosis, treatment, and course about published patients with SZP was extracted from PubMed database. SZP is classified into several categories: paresis of upper extremity, lower limb involvement, diaphragmatic involvement, and abdomen involvement. Published experiences have shown that clinical course and electromyoneurography of paretic muscle are the most important in the diagnosis; physical therapy is the most common therapy in these patients and their prognosis is generally good except diaphragmatic paresis, where there is no significant recovery in most number of patients.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/71254",risUrl:"/chapter/ris/71254",book:{slug:"human-herpesvirus-infection-biological-features-transmission-symptoms-diagnosis-and-treatment"},signatures:"Vesna Martic",authors:[{id:"271733",title:"Prof.",name:"Vesna",middleName:null,surname:"Martic",fullName:"Vesna Martic",slug:"vesna-martic",email:"vesnamartic.bgd@gmail.com",position:null,institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methods",level:"1"},{id:"sec_3",title:"3. Results",level:"1"},{id:"sec_3_2",title:"3.1 Data extraction and synthesis",level:"2"},{id:"sec_3_3",title:"3.1.1 Lower limb involvement",level:"3"},{id:"sec_4_3",title:"3.1.2 Diaphragmatic paralysis",level:"3"},{id:"sec_7",title:"4. Discussion",level:"1"},{id:"sec_8",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Peterson BH. Motor effects of herpes zoster. The Medical Journal of Australia. 1953;2(24):890-891'},{id:"B2",body:'Rhodes AJ, Van Rooyen CE. Textbook of Virology. Baltimore: William and Wilkins; 1962'},{id:"B3",body:'Oxman MN, Levin MJ, Johnson GR, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. The New England Journal of Medicine. 2005;352(22):2271-2284'},{id:"B4",body:'Yawn BP, Saddier P, Wollan PC, St. Sauver JL, Kurland MJ, Sy LS. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. 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The effect of treting herpes zoster with oral Aciclovir in preventing postherpetic neuralgia. A meta analysis. Archives of Internal Medicine. 1997;137:909-912'},{id:"B89",body:'Smith KJ, Roberts MS. Cost effectiveness of newer antiviral agents for herpes zoster: Is the evidence spotty? Infectious Diseases. 1998;178(Suppl):S85-S90'},{id:"B90",body:'Rice JP. Segmental zoster paresis in herpes zoster. Australian and New Zealand Journal of Medicine. 1985;15:712-716'},{id:"B91",body:'Esposito MB, Arrington JA, Murtaugh FR, et al. MR of spinal cord in a patient with herpes zoster brachial plexus neuritis. Journal of Neuroradiology. 1993;14:203-204'},{id:"B92",body:'Oliver WA. Diaphragmatic paralysis following cervical herpes zoster. The Medical Journal of Australia. 1990;153:555-556'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Vesna Martic",address:"vesnamartic.bgd@gmail.com",affiliation:'
Clinic for Neurology, Military Medical Academy, Belgrade, Serbia
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Christophides",authors:[{id:"154007",title:"Dr.",name:"Mathilde",middleName:null,surname:"Gendrin",fullName:"Mathilde Gendrin",slug:"mathilde-gendrin"},{id:"154008",title:"Prof.",name:"George",middleName:"K",surname:"Christophides",fullName:"George Christophides",slug:"george-christophides"}]},{id:"43829",title:"Bacterial Biodiversity in Midguts of Anopheles Mosquitoes, Malaria Vectors in Southeast Asia",slug:"bacterial-biodiversity-in-midguts-of-anopheles-mosquitoes-malaria-vectors-in-southeast-asia",signatures:"Sylvie Manguin, Chung Thuy Ngo, Krajana Tainchum, Waraporn\nJuntarajumnong, Theeraphap Chareonviriyaphap, Anne-Laure\nMichon and Estelle Jumas-Bilak",authors:[{id:"50017",title:"Prof.",name:"Sylvie",middleName:null,surname:"Manguin",fullName:"Sylvie Manguin",slug:"sylvie-manguin"},{id:"75315",title:"Prof.",name:"Theeraphap",middleName:null,surname:"Chareonviriyaphap",fullName:"Theeraphap Chareonviriyaphap",slug:"theeraphap-chareonviriyaphap"},{id:"88985",title:"Prof.",name:"Anne-Laure",middleName:null,surname:"Michon",fullName:"Anne-Laure Michon",slug:"anne-laure-michon"},{id:"88986",title:"Prof.",name:"Estelle",middleName:null,surname:"Jumas-Bilak",fullName:"Estelle Jumas-Bilak",slug:"estelle-jumas-bilak"},{id:"156016",title:"MSc.",name:"Chung Thuy",middleName:null,surname:"Ngo",fullName:"Chung Thuy Ngo",slug:"chung-thuy-ngo"},{id:"156018",title:"MSc.",name:"Krajana",middleName:null,surname:"Tainchum",fullName:"Krajana Tainchum",slug:"krajana-tainchum"},{id:"156019",title:"Dr.",name:"Waraporn",middleName:null,surname:"Juntarajumnong",fullName:"Waraporn Juntarajumnong",slug:"waraporn-juntarajumnong"}]},{id:"43899",title:"Distribution, Mechanisms, Impact and Management of Insecticide Resistance in Malaria Vectors: A Pragmatic Review",slug:"distribution-mechanisms-impact-and-management-of-insecticide-resistance-in-malaria-vectors-a-pragmat",signatures:"Vincent Corbel and Raphael N’Guessan",authors:[{id:"152666",title:"Dr.",name:"Vincent",middleName:null,surname:"Corbel",fullName:"Vincent Corbel",slug:"vincent-corbel"},{id:"169017",title:"Dr.",name:"Raphael",middleName:null,surname:"N'Guessan",fullName:"Raphael N'Guessan",slug:"raphael-n'guessan"}]},{id:"43851",title:"Perspectives on Barriers to Control of Anopheles Mosquitoes and Malaria",slug:"perspectives-on-barriers-to-control-of-anopheles-mosquitoes-and-malaria",signatures:"Donald R. 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1. Introduction
Modern civilization process brings on the one hand, better living standards, on the other hand, it has negative side effects in the form of impaired ecological, biological and natural conditions of life. Global environmental contamination is one of the most significant environmental problems at present. It is associated with an unprecedented boom in the utilization of chemicals in industrial and agricultural production. As a result, there is a relatively high concentration of toxic substances in the environment. These substances are not natural and are “strange” and „unfriendly “to the environment. Contaminants can be organic or anorganic compounds that are not naturally found in the environment; e.g., xenobiotics which can be found in unnaturally high concentrations (e.g. heavy metals) in individual environmental segments. The attention of professionals and lay public is mainly focused on hazardous substances, i.e. those that are difficult to decompose in natural surroundings, with high persistence and often exhibiting toxic effects on the environment [1, 2, 3].
Effects of environmental stress - sensitivity of a given organism to a certain stressor depends on its state of development and the conditions of its metabolism. When humans are concerned, especially the fetus, the newborn and the mother during pregnancy should be protected. Sick, weakened or weak individuals react very sensitively to environmental pollution. Smog disasters threaten humans and animals, and soil changes adversely affect vegetation. Very often not one, but several factors stress and pollute the environment. The simultaneous action of multiple factors may be substantially different than in the case of an individual effect; antagonistic, summative, synergistic, potentiating effects are recognized in these cases. It is true that the responses of biological system to environmental pollution can be: individual-level responses - (metabolic disorders stimulation or inhibition depending on stress level), production of chemical stress agents, changes in hormone levels (vertebrate adaptation syndrome), reproductive disorders, impaired orientation and even death in cases of extreme stress, population-level responses - extinction of sensitive individuals, change in size and age structure of the population, strong selection of genetically resistant individuals, general decline in genetic diversity within the population, extinction of populations, biocenosis and ecosystem level responses - change in competition and predator - prey-victim ratio, change in the field of parasitism and disease, change of species spectrum and elimination of sensitive species and spreading of resistant species, decline in biomass and diversity of species, change of closed metabolism system into an open one (partial or complete loss of minerals from natural deposits), change from equilibrium to imbalance, from ecosystem stability to instability, collapse of biocoenosis (in extreme cases). Toxic substances are particularly environmentally harmful to animal and human health, and thus, health risk assessment methods are particularly important in this respect.
Climate change, water, soil and health.Climatic conditions in Europe but also on other continents are changing. As a result of these changes, extreme weather-related events (floods, heat waves, droughts, forest fires, changes in vegetation, changes in the sea and ocean levels) are becoming more and more frequent. The change of the global climate, its impacts, and the need for solutions represent one of the most important and widely discussed environmental issues in human history so far. This change can be triggered by a number of internal and external factors, including human activity. Key effects caused by anthropogenic activity are the changes in greenhouse gas concentrations, ozonosphere disruption, local air pollution, land use and countryside exploitation. Given the complexity of the whole system, at present, it is extremely difficult to quantify precisely the human share on the total climate change. Subsequent assessment of the health consequences of the climate change is still relatively problematic, as most human health disorders are caused by several factors and take place against the backdrop of economic, social, demographic and overall environmental changes. The area of climate change, water and soil - international commitments - The UN Framework Convention on Climate Change, adopted in 1992 in New York, has become the basis for tackling climate change at international level. Its ultimate goal is to stabilize the impacts of the concentration of greenhouse gases in the atmosphere at a level that would prevent the dangerous consequences of human interaction and the Earth’s climatic system. In 1997, the Kyoto Protocol to the Convention was adopted to tighten up the commitments of individual countries (officially adopted in 2005). This is the first binding UN legislation in the area of environment. Already in 1979, at the UNECE Convention in Geneva, the so-called “Convention on Long Range Transboundary Air Pollution „ was signed. The basic aim is to protect the environment from air pollution respectively its gradual reduction. The Convention was supplemented by additional protocols related to the long-term funding of the Cooperative Programme for Monitoring and Evaluation of the Long-range Transmission (Geneva, 1984, Oslo, 1994), reduction of sulfur emissions or their transboundary flows (Helsinki, 1985), reduction of nitrogen oxide emissions or their flows crossing the borders (Sofia, 1988), limiting the emissions of volatile organic compounds - VOCs (1991), reducing emissions of persistent organic pollutants, reducing acidification, eutrophication and ground-level ozone. In the context of water protection at international level, already in 1972, the European Council proclaimed the European Water Charter, which highlights the vital importance of water and the inevitable need to protect and use water resources. “the Directive no. 2000/60/EC of the European Parliament and Council”, establishing the framework for the Community action in the field of water policy (WFD), which entered into force in 2000, provides the legislative framework for the introduction of a single policy in the countries of the European Union. Nowadays, the issue of water cleanliness and protection seems to be a priority, not only from a general and economic point of view, but above all from the fact that the quantity and quality of water is an essential factor in protecting and creating the environment [3, 4, 5, 6, 7].
2. Atmosphere
The word atmosphere comes from Greek (atmos -vapor, sfaira - sphere) and represents the gaseous layer around the Earth. It protects us from harmful cosmic radiation, harmful sunlight, solar winds and is the place where weather is created. There could be no life without the atmosphere. Gases forming the atmosphere are retained around the Earth by gravitational force. The composition and properties of air: Air is an essential component of the biosphere, without which the existence of various forms of life on Earth would not have been possible. The gases that create the atmosphere are kept around the Earth by gravitational force. The basic elements of the atmosphere are nitrogen (78.1%), oxygen (20.9%), argon (0.9%) and carbon dioxide (0.033%). The secondary components are noble gases (He, Kr, Ne, Xe), hydrogen, ozone, nitrogen oxides, ammonia, methane, iodine. The atmosphere provides protection from harmful cosmic radiation, harmful sunlight and solar wind. It has no significant upper boundaries, as it merges with space and rotates with the Earth. It is an essential condition for life as it transforms the radiant energy of the Sun, regulates the distribution of humidity and heat, and affects the spatial arrangement of the entire landscape. Based on the temperature-to-height dependence, the Earth’s air cover is divided into individual layers: the troposphere, the stratosphere, the mesosphere, the thermosphere, and the exosphere. The troposphere (from the Greek tropos - change) is the lowermost and the densest part of the atmosphere and makes up to 80% of its weight. It reaches 16–18 km above the equator, 8–10 km above the poles and 11 km in the temperate zone. With height, its temperature drops by an average of 0.65°C to 100 m. The temperature of this atmosphere layer is about 17 to −52°C. The composition of troposphere is quite constant. It contains about 78% nitrogen, 20% oxygen, small amounts of other gases and also contains virtually all water vapor. The troposphere is the most important layer of the atmosphere for life, with clouds being formed there and the occurrence of the majority of weather-related phenomena. The Stratosphere (from the Latin stratum - blanket) is the second major layer of the Earth’s atmosphere after the troposphere. It reaches a height of 45–50 km above the Earth. About 20–30 km above the Earth’s surface, the stratosphere contains ozone, which is called stratospheric ozone. It acts as a filter, trapping harmful ultraviolet radiation, and transmitting life-giving light and heat to the Earth. It completely absorbs UV-C radiation, which has lethal effects on the living organism and partially absorbs the short-wave UV-B radiation (wavelength of 280–315 nm), which is capable of causing many adverse effects. Although ozone in the stratosphere is naturally created and destroyed in a constant, balanced rate, people are gradually breaking this balance by using ozone-consuming substances. Increased penetration of UV-B radiation through the ozone layer increases the risk of skin cancer, cataracts and also contributes to immune system disruption. In addition, it damages crops such as soybeans, beans, disrupting the food chain in the oceans as well. Ozone also occurs in the lower part of the atmosphere as tropospheric ozone. Ozone in the ground level atmosphere has a harmful effect on living organisms. Unlike stratospheric ozone, tropospheric ozone does not protect organisms but, on the contrary, damages the respiratory organs of plants and animals. In recent decades, “good” stratospheric ozone has been decreasing and “bad” tropospheric ozone has been increasing. Air conditioners, fire extinguishers and chemicals such as Freon used in refrigerators and freezers can get to the stratosphere where they decompose and the released bromine and chlorine molecules thus destroying “good” ozone. One molecule of chlorine or bromine can destroy up to 100,000 ozone molecules, so ozone in the stratosphere disappears faster than it can naturally be supplied. Volcano explosions contribute only with a tiny amount, about 3% of the total, of chlorine to the stratosphere, while people contribute with 82%. The mesosphere extends to a height of about 80 km. This atmosphere layer is characterized by a temperature drop down to −90°C, which represents the lowest temperature area in the whole atmosphere. The reason for the temperature drop is extremely thin air and the near absence of ozone. It should also be noted that in the mesosphere the temperature varies depending on the season of the year. The boundary within the mesosphere is known as mesopause. Most of the meteorites falling onto Earth mostly burn in the mesosphere. The ionosphere represents the ionized part of the atmosphere that affects the propagation of electromagnetic signals. Located between 80 and 600 km in the mesosphere and thermosphere, it consists of neutral gas, ions and electrons. The thermosphere extends to the height of 690 km. The temperature rises with increasing height. It reaches up to 1500°C at a height of around 300 km and is no longer changing at higher altitudes. The thermosphere has the lowest density, it contains only 0.001% of the mass of the whole atmosphere. The exosphere is sometimes not even distinguished as a separate layer but is assigned to the thermosphere. It represents the highest layer of the atmosphere, more than 800 km above the Earth’s surface. In the exosphere, conditions for the release of atmospheric particles into the interplanetary space arise [8, 9, 10]. Air Contamination, Causes, Consequences: The air that mankind has not been paying attention to (and did not have to pay) in the past, is nowadays becoming an acute and widely discussed issue. Since air is not inexhaustible. Its pollution is more perceptible from year to year. There are always new ways and means of its pollution, which also affect their originators, people, animals and nature. A pollutant is any substance introduced by human activity directly or indirectly into the air that has or may have harmful effects on human health or the environment, except for a substance the introduction of which into the environment is governed by a specific regulation. Emission is any direct or indirect release of a pollutant into the air. A stationary source of air pollution is a technological complex, warehouse or landfill of fuels, raw materials and products, waste dump, quarry or other area with the possibility of steaming, burning or polluting or other construction, object, equipment and activity that pollutes or can pollute the air; it is defined as the sum of all facilities and activities within a functional unit and a spatial unit. A mobile source of air pollution is a mobile device with an internal combustion engine or other propulsion engine that pollutes the air. The air is polluted by the discharge of various substances into the atmosphere and the processes taking place directly in the air. The atmosphere is under increasing pressure from greenhouse gases, which represent climate change and under pressure from ozone depleting chemicals. Pollutants, including substances that cause acid rain, are often transferred over long distances, thus damaging soil and water. Air pollution is the introduction of pollutants into the atmosphere which, either directly, after a chemical change or by interaction with another substance, adversely affects the environment. We know various sources of air pollution, namely anthropogenic and natural, which include: combustion of fossil fuels in electricity generation, transport, industry and households, industrial processes and the use of solvents, for example in the chemical and mineral processing industries, agriculture, waste treatment, volcanic eruptions, windblown dust, sea salt spray, and emissions of volatile organic compounds from plants are examples of natural emission sources. Within broader understanding of air pollution, we also include harmful electromagnetic radiation, noise, heat, etc., among pollutants. The following inorganic substances pollute the air: sulfur oxidation products (sulfur dioxide, sulfur trioxide, sulfuric acid, sulfates), which are introduced into the air by the combustion and processing of coal and oil. Nitrogen oxidation products (nitrogen oxide, nitrous acid, nitrates) that enter the atmosphere as products of biological processes (bacterial activity), from combustion processes in industry and transport. Carbon monoxide is produced in combustion processes where there is insufficient oxygen supply to the burning fuel (exhaust gases of motor vehicles and air planes, heating). Anthropogenic emissions - beryllium (Be), cobalt (Co), antimony (Sb), selenium (Se) - arise mainly from coal combustion, nickel (Ni) and vanadium (V) are predominant in the combustion of diesel, arsenic (As), cadmium (Cd), copper (Cu) and zinc (Zn) are emitted mainly when melting non-metallic ores. Chromium (Cr) and zinc (Zn) are released from the iron and steel works. Inhalable and respirable particles, which can penetrate up to the alveoli [11], are considered to be dangerous to health. Other important substances - volatile organic compounds (VOC), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), dioxins are measured selectively in targeted studies. In case of any harm to human health, animals and beasts by the action of pollutants, the emphasis is mainly on the effects of generally toxic, allergenic, carcinogenic, mutagenic, teratogenic substances. Immissions are substances that affect the soil, water, plants, animals and humanity. The composition of the air and its properties are variable, so its effect on the organism changes. In terms of place of origin, air pollution is divided into primary and secondary. Primary air pollution is the release of pollutants from the source of pollution. Secondary air pollution refers to chemical changes in some substances occurring in the process of spreading airborne exhalates. The level of air pollution is expressed by the instantaneous or average concentration of pollutants at a particular location and depends both on the emissions of pollutants and on the processes to which these emissions are subject in the air. This level is characterized by detected pollutant emissions. Polluted air damages the environment or its components, endangers or damages the human and animal organisms and impairs the environment by deteriorating odor, reducing visibility, etc. [2, 3, 10, 11, 12, 13].
The Causes of Air Pollution: Increasing population and living standards, including energy requirements, are the main cause of the increase in air pollution. The global economy, which meets the demands of an advanced society, is characterized by increasing oxygen consumption and the release of gaseous, liquid and solid emissions. Depending on the volume of the polluted air, pollution can be divided into local (covering areas with units of tens of km2 – i.e., air pollution of cities and industrial areas, changes caused by changes in local emission and meteorological conditions), regional (bottom troposphere pollution of entire territorial unit, in assessing regional air pollution, it is necessary to analyze the long-term impact and its consequences on soil, water and sensitive ecosystems) and global (pollution of the free atmosphere, changes in the composition of the atmosphere as a whole; the most serious pollutants being carbon dioxide and small particles of solid and liquid substances) [3, 9]. Carbon dioxide (CO2) - the natural source of carbon dioxide emissions is the breathing of aerobic organisms, while the process leading to its natural decrease is the photosynthesis of green plants and the oceans represent the ways to absorption. The mean residence time in the atmosphere is estimated to be 2–4 years. The total CO2 content is increasing - over the last 100 years the CO2 concentration has increased by about 10%. The increase in CO2 in the atmosphere is responsible for the worsening of the greenhouse effect. Anthropogenic sources are mainly combustion processes. Other natural processes emitting carbon dioxide include fires and volcanic activity. Carbon dioxide is emitted wherever combustion processes of carbon fossil fuels (natural gas, petroleum products, coal, coke) occur. The source of emissions is also the combustion of fuels of biological origin (biomass, wood, biodiesel and biogas). Carbon dioxide in the atmosphere absorbs the infrared radiation of the Earth’s surface and thus contributes to the greenhouse effect and consequently to global warming. In higher concentrations, in poorly ventilated areas, it may exhibit toxic effects. Short-term exposure may cause headache, dizziness, difficulty in breathing, confusion immediately or with a short delay. Higher exposure may cause cramps, coma, or death. Some more serious cases of poisoning can leave brain effects, cause personality changes, and impair vision. Carbon monoxide - has an uncontrolled radiation impact on the atmosphere in connection with increasing methane concentration and increasing of the ozone hole. CO belongs to the photochemically active gases contributing indirectly to the greenhouse effect of the atmosphere. It is known as a precursor of ozone because it affects the formation and breakdown of ozone in the troposphere. The atmospheric residence time estimates vary, with a range of 0.1–0.3 years, some 1 month to 5 years; this also depend on the carbon monoxide removal rate. The major part of CO is formed in the atmosphere during methane oxidation, chlorophyll decomposition and terpene photooxidation. Volcanic activity, forest fires and bacterial activity in the oceans contribute to the total amount produced by natural resources. Anthropogenic activity is letting into the air from 350 to 600 million tons of CO per year. The most important emission sources include imperfect combustion, e.g. in automobiles, industry, incinerators and heating plants and incomplete combustion of carbon-containing organic substances. It is one of the most common poisons. When inhaled, it is absorbed into the lungs and re-bound to the blood dye, producing carboxyhemoglobin. CO has 200 some literature reports up to 240–300 times more affinity for blood pigment than oxygen [13, 14]. Hydrocarbons - the largest share is methane gas from natural resources. The second largest group is represented by terpenes from natural sources. From human activity, comes less than 5% of the total volume of hydrocarbons, of which 38.5% comes from combustion, 11.3% from solvent evaporation, 8.8% from the evaporation of crude oil and transport losses, 7.1% from refinery waste. In terms of air pollution, the combustion of hydrocarbons is of the utmost importance. When hydrocarbons enter the atmosphere as products of combustion processes, they react with the components of the polluted atmosphere or undergo photooxidation or photolysis. The most serious ones are those that create photooxid smog. Significant hazard to ozone depletion is represented by freons and halons. Nitrous oxide belongs to stable atmospheric components. The only source of nitrous oxide are natural processes. When converted into nitrogen, nitrous oxide represents 97% of all nitrogen compounds, remaining present in the atmosphere approximately for 4 years. Its larger part returns to the Earth’s surface, of which about 6% diffuses into the stratosphere, where it disappears in photodissociation. Of the total amount of N2O that undergoes a reaction, 98% is changed to N2 in the atmosphere and 2% is converted to NO. Nitric oxide - most of it comes from natural sources. From anthropogenic activity, combustion processes (emissions from energy, municipal sources and transport) contribute significantly to NO emissions. The residence time in the atmosphere is estimated to be about 4 days. NO arises from combustion processes at sufficiently high temperatures. Under equilibrium conditions in the presence of oxygen, most NOs oxidize to NO2, changing colorless nitric oxide to colored nitrogen dioxide. In the mesosphere and thermosphere, the photodissociation of nitric oxide is taking place, which presents the way of NO disappearance in the higher atmosphere. The photochemical conversion of NO to NO2 can be of considerable importance for the air pollution in urban agglomerations. Nitrogen dioxide -Most of the nitrogen dioxide is produced directly in the polluted atmosphere by NO oxidation. Significantly less is released into air from anthropogenic sources. The removal of NO2 from the atmosphere starts from its oxidation and hydration, resulting in nitric acid. Nitric acid in the polluted atmosphere can further react to form nitrates, which in the final phase are washed away by rain. In terms of air pollution, NO2 photolysis, which can initiate photochemical smog, is of paramount importance. The formation and duration of photochemical smog depends on the chemical composition of the polluted atmosphere, the intensity and spectrum of the solar radiation. It is often created on warm sunny days at rush hours. Ammonia - the largest amounts of ammonia - are released into the atmosphere by the biodegradation of organic matter and by the reduction of nitrites or nitrates. Anthropogenic sources include the chemical industry, especially the production of fertilizers and urea and industrial waste. Ammonia gas reacts in an atmosphere with sulfuric acid, respectively nitric acid to form sulfates or nitrates. Self-cleaning processes occurring in the atmosphere such as sedimentation and rainwater rinsing allow the resulting salts to be removed from the air. The residence time in the atmosphere is estimated to be about 7 days. Sulfur dioxide is one of the typical and most common emission components. The largest amounts are produced by burning fossil fuels. Natural resources contribute to a lesser extent to total SO2 emissions (emissions from volcanic activity). Sulfur trioxide is produced by burning fossil fuels. Small amounts get into the atmosphere due to the production of sulfuric acid, phosphate fertilizers or in galvanic plating. In the atmosphere, SO3 reacts immediately with H2O to form sulfuric acid. The sulfuric acid content increases with increased SO2 concentration up to a certain critical value, from which the SO2 content decreases further on. Sulfane-the main global source of sulfane emissions are natural processes such as volcanic activity and biological processes of substance degradation. Anthropogenic activity contributes to these sources only minimally, in the processes of oil, coal, pulp and paper processing. In the atmosphere, sulfate is gradually changing due to the oxidative effects of air oxygen with the contribution of solar radiation and due to the hydrolytic reactions with atmospheric moisture to form sulfuric acid. If other pollutants get into the air together with sulfate, the number of possible reactions is increased by combinations with primary and secondary pollution. Consequences of air pollution: ozone layer depletion (referred to as the ozone hole) is present in areas mainly above the Arctic and Antarctica with reduced ozone concentration due to anthropogenic pollution. In the ozonosphere there is a constant cycle of ozone formation and disappearance. In the presence of sunlight, photochemical processes occur, resulting in higher ozone concentrations. The most important thing concerning life on Earth is that most of the ultraviolet radiation is trapped in these processes and the visible light is transmitted to the Earth’s surface. Ozone is a gas that is poisonous at higher concentrations. Therefore, in the troposphere where we live, it is undesirable, but in the stratosphere it is essential for life, as it absorbs dangerous UV radiation. Since 1970, we have been observing the depletion of the ozone layer around the entire globe. It is caused by civilization influences. At present, we know more than 200 chemical reactions of the ozone decomposition process. Depending on which parts of the atmosphere contain ozone, it can play a positive or negative role. Tropospheric ozone is ozone found in lower parts of the atmosphere, which is harmful to living organisms. Unlike stratospheric ozone, its concentration in the troposphere is increasing. Excessive ozone amount in the troposphere is as harmful as its lack in the stratosphere. Tropospheric ozone can be of stratospheric origin or is a result of complex photochemical reactions of hydrocarbons, carbon monoxide and nitrogen oxides. Stratospheric ozone - ozone found in the stratosphere prevents the penetration of harmful short-wave UV-B radiation with a wavelength of 280–315 nm. As a consequence of photochemical reactions in the stratosphere, besides the formation and decay of ozone, not only is there a significant attenuation of the incident solar ultraviolet radiation, but also the transmission (absorption) of energy, and thus an increase in temperature in the respective atmosphere layers. As a result of human activity, substances are released into the atmosphere, the amount of which exceeds the normal value of their occurrence in the atmosphere several times. This reduces the amount of ozone in the ozonosphere and disrupts the natural structure of the atmosphere, which permits much more UV-radiation at wavelengths that adversely affect living organisms. The stratospheric ozone layer is increasingly disrupted by the action of chlorofluorocarbons (CFCs or Freons). Freons have been developed in the 1930s, have a very wide use, are non-flammable, non-toxic, odorless, cheap and lighter than air. As a result of UV-radiation, the atoms of the halo elements (chlorine, bromine) are released, converting ozone to oxygen molecules that do not absorb UV. The decrease of ozone in the stratosphere allows ultraviolet rays to get to the Earth. Negative effects on living organisms include skin cancer, eye diseases, weakening of the immune system and others [3, 10, 13, 14, 15]. Ultraviolet rays do not only damage living organisms, but also contribute to the deterioration of plastics, wood, paper and cotton. The amount of both tropospheric and stratospheric ozone depends on the balance between the processes in which ozone is produced and the processes in which ozone is disposed of in the atmosphere. In the last quarter of the 20th century, it was found that stratospheric ozone was disappearing, while tropospheric ozone was increasing. Even though stratospheric ozone is naturally produced and destroyed by a constant, balanced rate, people are gradually disrupting this balance by using ozone-consuming substances. Acid rain is the result of strong air pollution, where dirt absorbed by air humidity gets back to the ground through precipitation. Rainwater with a pH value of 5.0–5.6 is slightly acidic because carbon dioxide is found in the air and absorbed by the air humidity. Acid rain is considered to be rainwater with a pH of 2.0–5.0. The occurrence of acid rain is mainly due to coal and oil-fired power plants, metallurgical plants, the chemical industry and transport. Sulfur and nitrogen oxides emitted by these sources combine with atmospheric moisture to form sulfuric and nitric acids. These rains have a negative impact on flora and fauna. They kill fish in lakes in bulk. Acid rain threatens plants, forests (healthy coniferous trees lose their needles after 6–8 years, sick ones after 2–3 years, only the newest needles remain on damaged coniferous trees, plant roots absorb toxins more easily in acidic environment) worms, insects and other animals that process plant remnants in healthy soil (thus enriching the soil with substances that are vital to plant life). However, if the soil is acidified by acid rain, the animals cannot live in it. Dead plant residues remain lying on the ground and no animal nutrients are formed. The food chain is disrupted. Some of the nutrients such as calcium, manganese, sodium, potassium is diluted from the soil due to the effects of acidic components of the rain; groundwater and surface water are (acidified water has a negative effect on aquatic animals and aquatic plants). Under these conditions, phytoplankton gradually disappears and due to its reduction, the light gets deeper into the water, so the water of the affected lakes is almost unnaturally clear and clean. Today, for example, only in Sweden out of 100,000 lakes, (about 20,000 are dead, lifeless), acid rains are damaging buildings, artistic and cultural landmarks. Not all sites respond to acid rain in the same way - it depends on the soil and water chemical composition. There are some sites with alkaline soil that can tolerate large doses of acid rain without significantly changing the overall pH of the environment. Acid aerosols also have a harmful effect on humans by entering the respiratory tract, irritating the mucosa and thus facilitating the entry of infections into the lungs. The greenhouse effect is the denotation of a phenomenon consisting of warming the lower layers of the atmosphere due to the fact that the atmosphere permits the passage of short-wave solar radiation to the Earth’s surface during the day and absorbs Earth’s long-wave radiation at night and thus becomes warmer. Larger wavelength heat radiation, which is emitted back from the planet’s surface, is absorbed by the Earth effectively, its immediate release into space being prevented this way. The anthropogenic greenhouse effect is caused by the burning of fossil fuels, the excavation of forests, the global changes in the countryside, and contributes to global warming. Among the greenhouse gases currently having the greatest climate impact belongs carbon dioxide. It occurred naturally in the atmosphere. From 1850 to the present, its concentration increased by 27%. It is released in the burning of fossil fuels and its amount is growing due to massive deforestation too. Part of it is absorbed by the oceans and much of it by forested areas. Another significant greenhouse gas is methane. In the atmosphere it occurs naturally, as does carbon dioxide. It is produced by anaerobic bacteria in the digestive tract of ruminants and by the decomposition of organic matter. It is released from subsurface landfills and is also released into the atmosphere by escaping from gas pipelines. Nitrous oxide is a naturally occurring greenhouse gas. Its presence is increased by using nitrogen fertilizers and burning fossil fuels. Freons have anthropogenic origin. They are found in refrigerant gases and are part of the propellants. They disrupt the ozone layer. We are currently adding nearly 10 billion tons of carbon to the atmosphere annually. The biosphere is not capable of returning such an amount back to underground reservoirs as fossils, nor is the world ocean able to drain such an amount of carbon because of physical and chemical limitations. This is the main reason that the concentration of CO2 but also of CH4 in the atmosphere grows in parallel with the consumption of fossil carbon by various anthropogenic activities. Nitrogen is an indifferent part of the air in respect to health. Oxygen is the most important component of air, resulting from its role in respiratory physiology. The human organism is highly resistant to fluctuations in the amount of oxygen. Ozone is of little use for low concentration under natural conditions. However, it is harmful and even dangerous at high concentrations. Carbon monoxide is an unnatural admixture in the air. Its hygienic importance lies above all in the danger of poisoning. It is particularly dangerous because humans cannot smell it. Sulfur dioxide is produced by the combustion of sulfur and acts irritatingly and even as a strong poison. Ammonia occurs only in trace amounts in the atmosphere. It is harmful at a concentration of 0.5%, which it practically does not reach. Odorous substances are produced in an enclosed atmosphere by anthropogenic and animal activity. Further impurities in the air are e.g. mercury, and gasoline vapor, hydrogen cyanide [3, 6, 10, 14].
3. Hydrosphere
Hydrosphere (from Greek hydro - water) is a denotation that encompasses all water, whether on the surface of the Earth or bellow it and in any form… Water is the most widespread, under the surface of the Earth. Water occurs in different states and creates a discontinuous water layer of the Earth (hydrosphere). These include the waters of the oceans, seas, surface waters, and, in a broader sense, soil and groundwater, water bound in glaciers and snow, atmospheric water, and water in living organisms. on the Earth and for the animals it is directly the environment for their living. It is the main means of transporting nutrients, receiving and excreting them. Water on Earth occupies about 2/3 of its total surface area (drinking water represents about 1% of the total water; 97% saltwater contained in seas and oceans; 2% water bound in glaciers). The total water volume is about 1385 billion km3. The origin and development of the hydrosphere is closely linked to the evolution of the rest of the Earth. Between the lithosphere, the atmosphere and the hydrosphere, there is a constant exchange of water causing changes in the chemical and isotopic composition of water. Continuous water circulation is caused by solar energy and gravity. Large (global) water cycle takes place between the ocean and the mainland, and a small water cycle arises over the oceans. In the various phases of the cycle, complex water conversion takes place [3, 6, 10]. Meaning, function, properties and distribution of water: The health of the population as a universal value and primary human rights represent the fundamental economic resource not only for the individual but also for the whole of society. In recent years, information has been gathering to warn of the catastrophic effects of unscrupulous industrial devastation of natural resources, water resources, and interventions in the ecological balance of flora and fauna. Water is an indispensable component of the human environment, as well as all plant and animal systems, and constitutes the basic condition of life on Earth. It is an important prerequisite for the existence of every living matter on Earth. The importance of water for man and the environment was accurately defined in the 12 points of the European Water Charter, proclaimed by the European Council on 6 May 1948 in Strasbourg: The Water Charter underlines the necessity to maintain sufficient water for future generations and the fact that water does not recognize state borders. Therefore, the growing water problems require international cooperation. According to data from the United Nations, polluted water kills more people than war. Up to 2 billion tons of polluted waste is discharged daily into the water worldwide. About 2 million people die of dehydration in developing countries every year on our planet, with about one in five people having no access to drinking water. More than 3000 children younger than 5 years die from diarrhea, dysentery, dehydration and cholera daily. According to the UN, about 783 million Earth inhabitants does not have access to drinking water and about 2.5 billion people do not know sanitation systems, while the quality of water resources is worse. The human body contains more than 60% water (65–75%), which is about 2/3 of the body weight. This ratio is even higher in children and newborns. Water plays an irreplaceable and irredeemable role in the life and function of the body as it participates in the digestion and metabolism, body temperature regulation, excretion of body waste, transport of oxygen and nutrients to tissues and cells. The amount of drinking water received depends on several factors: age, activity, environment in which a person lives, condition of the body, nutrition (composition of diet). Lack of water leads to serious damage to the human body after only a few days. In the case of excessive loss of water from the body, we feel drowsiness, weakness, confusion. Dry mucous membranes, constipation, headache, fatigue, somnolence, impaired movement coordination, pulse acceleration, drop in blood pressure and decreased performance are also manifestations of water deficiency. In case of excessive fluid loss, we are talking about dehydration. Loss of fluid above 6% can lead to collapse or death. In the case of insufficient water supply, harmful substances accumulate in the body, which puts the excretory organs under stress. The thicker the blood, the more difficult it becomes for the kidneys to deal with the waste. Water in tissues, blood, and lymph are thickened, weakening the immune system, failing to transmit nerve impulses, slowing cell renewal. Water is also important for thermoregulatory processes and protects the body from overheating. Water functions: biological function – it is the essential condition for the life of organisms from microorganisms to higher animals to humans, it provides nutrition for humanity, for some animal species water is their living environment, water participates in photosynthesis, it is part of components in the cell as well as regulator of thermal properties, health preserving function - the quality of life, hygiene, health, healing properties of mineralized and otherwise enriched waters depend on it; economic function – it is applied in the agricultural industry, esthetic-cultural functions - spas, water bodies fulfill the appropriate function, political function - watercourses form borders between states. Water properties: The physical, chemical and biological properties of water result from its structure and chemical composition. From a physical and chemical point of view, water is a very complicated compound characterized by a number of special chemical and physical properties resulting from the electron structure of its molecules. Water properties are divided into chemical, physical, microbiological and sensory. The chemical properties of water - water contains a wide range of chemicals, some of which are only minuscule and desirable (carbonates); others should only be present in limited quantities because they could change the color and haze properties (turbidity) of water (iron, chlorine) and there is also a group of substances undesirable in water that indicates water pollution with nitrogenous substances (ammonia, nitrites, nitrates, phosphates, chlorides) of organic origin, etc.) [6, 14]. The chemical properties of water are determined by the content of substances dissolved in water. The main inorganic constituents of natural waters are calcium, magnesium and sodium, which are mostly present as cations such as bicarbonates, sulfates and chlorides. In natural waters, potassium, iron, manganese and small amounts of other metals are represented in small concentrations, by which the water is enriched in contact with the soil, with various minerals and rocks. From a chemical point of view, we divide the substances found in waters into inorganic and organic. From a physical point of view, these substances can be present as ionically dissolved (electrolytes), non-ionically dissolved (non-electrolytes) or as undissolved (non-miscible, miscible and buoyant or floating). Physical properties of water: ability to accumulate more heat; large water bodies such as lakes, seas and oceans are involved in the regulation of temperature on the Earth, electrical conductivity, which depends on ion concentration, their mobility and temperature, while the dissolved salts and gases increase the water conductivity, the water density increases from temperature of 0 to 3.98°C, at higher temperature it decreases continuously, surface tension - is the cause of capillary phenomena (capillarity of water in the soil and rocks, wetting ability, foam formation, etc.), viscosity, which together with density significantly affects hydraulic water behavior - for example, the speed of sand filtration of water depends on its value, sedimentation rate that decreases with temperature rise. Other physical properties of water include light absorption, water radioactivity, and state changes. Biological properties of water: The microbial recovery of natural waters consists of autochthonous (indigenous) species, for which water is the primary and natural habitat, where they participate in the circulation of substances in water and are thus reflecting natural water pollution without anthropogenic influence. Microorganisms that get into the aquatic environment by flushing from the soil, or through civilization wastes, whether communal, industrial, or agricultural, and survive for some time in this environment, represent an allochthonous (non-original) recovery, indicating not only external pollution by organic substances, but also the possibility of pathogenic germs. There are many microbial species in natural waters. Microbiological analyzes are carried out in a targeted manner, and indicator groups or individual species of microorganisms as indicators of water quality are selected purposefully according to ecological or hygienic criteria. Ecological classification of organisms expresses the behavior and application of organisms in certain physiological conditions and their ability to survive and adapt in new and more difficult conditions. Systematic division of organisms is done either from the perspective of their development or family relationships. This includes microorganisms, plants and animals. Ecological division relates to the participation of organisms in the circulation of substances in the aquatic environment and recognizes producers, consumers and destroyers. Producers are organisms able to assimilate inorganic nutrients and synthesize organic substances such as carbohydrates, proteins and fats from them. These include autotrophic bacteria, higher plants, algae, cyanobacteria. The source of energy is either light radiation, e.g. for algae, photosynthesis in plants or some oxidation–reduction reactions. In the case of photosynthesis, in addition to organic substances, producers also generate oxygen which can enrich water and air. Producers are the bases of aerobic life on the Earth and their photosynthesis is significantly utilized in self-purification of water. Consumers feed on finished organic substances that are processed by endoenzymes inside their bodies. Consumers include animals from protozoa to arthropods. Together with destructants they represent an organotrophic (heterotrophic) diet. Consumers release the waste substances of their metabolism into the water, especially carbon dioxide. Decomposers feed on finished organic substances. Since they do not have any food intake organs, they decompose high molecular weight substances outside of their body by exoenzymes into simpler molecules that can penetrate the cell wall into a destructive cell [3, 10, 13, 14, 15].
3.1 Division of water by origin, pollution, causes
Precipitation (atmospheric) water forms - occur in the air in the form of clouds, water vapor, precipitation and fog. This type of water is considered the cleanest, but it is contaminated by passing through polluted air layers. The greatest influence on the chemical composition of atmospheric waters has a layer of atmosphere that extends from the Earth’s surface to a height of 1000–1500 m. Surface water - represents water that is permanently or temporarily on the surface of the Earth and is divided into: flowing (natural - streams, rivers, artificial - canals, conduits), stagnant (natural - seas, oceans, lakes, artificial - ponds, water reservoirs). Pollution of surface waters – the so-called “Eutrophication” is a set of natural and man-made processes leading to an increase in inorganic nutrients in water, especially nitrogen and phosphorus compounds, followed by increased growth of cyanobacteria, algae and higher plant forms, resulting in worsened ecological stability and reduced water quality. Phosphorus in surface waters comes from sewage and phosphate fertilizers used in agriculture. Nitrogen and phosphorus compounds mainly come from waste related to animal husbandry, industrial production and from sewage “water”. An important source of surface water pollution is the excessive application of NPK fertilizers to the soil. It occurs mainly in stagnant, slow-flowing waters, but eutrophication can also occur in watercourses under favorable conditions (strong nutrient supply, increased water temperature and slowed flow of water). Groundwater is created by infiltration of rainwater and surface water into the Earth’s crust. Groundwater is of fundamental importance in the hydrological cycle in supplying the population with drinking water. Groundwater pollution by nitrates is an issue that has been given increased attention in the area of groundwater protection against pollution The increased level of nitrates in groundwater is contributed to by anthropogenic activity, e.g. the application of industrial and artificial fertilizers to agricultural land, discharge of waste water from settlements and industrial buildings. Increased concentrations of nitrates in groundwater have a negative impact on both the environment and human health, since groundwater is preferably used as a source of drinking water. In particular, the prevention of groundwater pollution by nitrogen compounds is provided by integrated territorial protection of areas with potentially endangered groundwater bodies. Thus, contamination of water resources can be physical (occurrence of insoluble sludge and radioactive substances), chemical (water-soluble impurities), biological (germs present). Thus the pollution itself occurs by the already mentioned increased use of fertilizers and pesticide preparations, leakage of silage juices, leakage of liquid parts of fertilizers from farms, leakage of lubricating oils, fuels and so on. Pollutants (substances contributing to pollution) - substances directly toxic (heavy metals, cyanides, pesticides), water pollutants (dyes, oil and relates substances), substances affecting the amount of oxygen in the water (high levels of degradable substances, at the decomposition of which large quantities of O2 in water are consumed), inert inorganic substances dissolved, undissolved, non-toxic [3, 10, 13, 14]. Causes of water source pollution-Man affects the quantity and quality of water resources directly through uncontrolled discharge of wastewater into watercourses or through sewerage networks. Waste water producers in the Slovak Republic are mainly industry and municipal sphere - sewerage systems of towns and villages. Inadequate purification results in high concentrations of pollutants and substances supporting the development of algae and plankton - phosphorus (P), nitrogen (N) - into the surface waters, resulting in an overall deterioration of water quality in streams and in stagnant waters (eutrophication). In the area of groundwater quality in the Slovak Republic, the issue of adverse oxidation–reduction conditions is at the forefront, which is often indicated by increased concentrations of iron (Fe), manganese (Mn), and NH4. Almost all metals are naturally found in surface and groundwater. Many of them are indispensable to life but may be harmful at higher concentrations. Metals with toxic properties, which are among the most important inorganic contaminants of waters and soils, become hygienically serious. The presence of cadmium (Cd), mercury (Hg) and chromium (Cr) is currently one of the most recent risks. Toxic metals have a negative impact not only on the surrounding environment, but especially on human and animal health. They also have an impact on flora and fauna [3, 8, 15, 16, 17].
4. Pedospere
Soil is a natural formation that arises directly on the Earth’s surface as a product of the interaction of climatic conditions, organisms, humans, relief and parent rocks Act 34/2014 Coll., amending and supplementing Act 220/2004 Coll., On the (Protection and Use of Agricultural Land). Soil is a complex system of abiotic and biotic components and is the result of soil-forming factors. It is created on the interface of the atmosphere, the lithosphere, the hydrosphere and the biosphere, which to a great extent influences its composition. In the soil-forming processes, abiotic and biotic environmental factors are applied together, and the result of their action is the abiotic-biotic component of the environment - soil. The main abiotic factors involved in soil formation include: parent (soil-forming) rock, relief, water and climatic conditions. The chemical composition of the soil depends primarily on the parent rock from which the soil originated, from the processes running in the soil and from the activity of man. Soil contains most oxygen (about 50%) and silicon (about 25%), other elements are mainly aluminum (clay), iron, calcium (limestone, gypsum), sodium, potassium, magnesium, hydrogen, titanium, in lesser amounts carbon, chlorine, phosphorus, sulfur and manganese. Biotic agents include soil edaphone. These factors are collectively called soil-forming factors. Edaphone is a living component of soil. It is a set of soil microorganisms, fungi, plants and animals. Soil organisms (geo bionti, edafonti) live in slots washed out by air or water, especially in the surface layers of the soil. For humification processes, plants, bacteria, and mycophytes are the most important. The root system of higher plants ensures the mechanical movement of the soil and keeps it loose. Bacteria break down organic matter in the soil. The soil contains both autotrophic and heterotrophic bacteria. Bacteria can have diverse functions in the soil. Decomposition of animal, plant and microbial residues is performed by heterotrophic bacteria. Chemoautotrophic bacteria in the soil are predominantly represented by nitrifying bacteria and, to a lesser extent, sulfur-oxidizing bacteria. The most common microbial cells in the soil are single-cell prokaryotes. Despite their high concentration in soil, fungal biomass predominates over the biomass of bacteria. Soil bacterial flora is extremely diverse and is dominated by Gram-positive bacteria. Fungi dominate the soil in terms of biomass amount. They are eukaryotic and have a mycelial morphology consisting of mycelia that surrounds the multinuclear cytoplasm. They live in symbiosis with most plant roots, which are of great importance for regulating nutrient uptake, aquatic connections and ultimately the growth of a plant partner in this community. Soil spore production allows to some extent their survival under unfavorable soil conditions. Fungi also include many important plant pathogens. Bacteria, worms, insects and other animals process plant residues in healthy soil. In this way, soil is enriched with substances that are vital for plants. However, if the soil is acidified by acid rain, the animals cannot live in it. Dead plant residues remain lying on the ground, no nutrients are created for the animals, and the food chain breaks. Soil contamination, causes, monitoring: we consider soil to be one of the main components of the Earth’s ecosphere. It forms the basis of the nutritional chain at the end of which man stands [2, 18]. The most important soil characteristic is fertility, the ability of the soil to provide plants with water, air, nutrients in optimal quantities throughout the vegetation [19]. The soil system is a very specific component and to some extent can effectively and naturally eliminate various foreign substances. Soil and ecosystem components - water and air - are basic indicators of pollution. The soil loses most due to contamination since its ability to eliminate the negative effects caused by the natural and anthropogenic activity of man become limited [20, 21, 22]. Major problem of consumer society is waste production. The issue of waste does not end with the disposal of waste in landfills. Precipitation waters that infiltrate through landfills are contaminated with waste materials. Such landfill leachates can then contaminate the soil or the bedrock where the landfill is located. Another factor that negatively affects soil environmental functions is the contamination of soil by water and air. Pollutants in air and water are mainly from industrial production. Toxic heavy metals, like biogenic metals, are present in the soil in two mobilities. They occur in the liquid phase as hydrated ions or as soluble organic and inorganic complexes. In the solid phase they are in the form of insoluble precipitates on the surface of organic and inorganic colloids in exchangeable and specifically absorbed form. A dynamic equilibrium is created between the various forms, in accordance with the characteristics of the system. If e.g., a large amount of toxic substance gets into the soil, absorption and precipitation reactions predominate. On the other hand, when the acidity of the soil increases, the number of mobile forms increases, i.e., the concentration of metal ions in solution increases. Contamination of the soil by sulfur dioxide exhales is leads to its acidification. Low pH causes increased mobility of cadmium and aluminum, which can intoxicate plants. Other contaminants also enter the soil through sedimentation: nitrogen oxides, lead, cadmium, arsenic, fly ash, chromium, nickel, organic compounds. Lead polluting soil comes mainly from automobile traffic. The source of cadmium is the burning of fossil fuels. The arsenic from the power plant ash dissolves well in the water and therefore does not accumulate in the topsoil but passes into the lower layers. Acidification of the soil in already contaminated areas is particularly dangerous as heavy metal compounds are normally insoluble, but when mobilized, they can result in a serious environmental damage (timed chemical bomb). Soil is an important geochemical reservoir, which relatively easily accumulates heavy metals. They are removed only very slowly, by leaching processes into subsurface waters or by plant bioaccumulation. Soil is the starting point for the entry of risky elements into crops and through forage into animal products [23, 24]. Soil contamination with water occurs as a result of soil irrigation or rainfall activity. Erosion is one of the most serious problems threatening soil worldwide. The erosion is due to the spread of mountain farming, the excavation of forests, the deterioration of the soil’s water regime, the plowing of grasslands, the artificial regulation of watercourses, the wrong land cultivation. The result of erosion is the drainage of soil parts, humus, nutrients, crop reduction. As reported by the authors [13, 15, 25, 26]. industrial emissions primarily affect the pollution of agricultural and forest land. Especially increased content of lead (Pb), zinc (Zn), tin (Sn), cadmium (Cd), aluminum (Al), copper (Cu), nickel (Ni), mercury (Hg), manganese (Mn), and arsenic (As) was found in the vicinity of metallurgical factories. All metals usually get into the soil, but increasingly those components that dominate the immission type. The most important metal pollutants of soil are mercury (Hg), cadmium (Cd) and lead (Pb), which are generally toxic to humans and animals [2, 3, 9, 16, 27].
4.1 Health risks of environmental pollution, risk analysis, evaluation
Increasingly polluted environment, preservatives, dyes and flavorings present in the food are heavily burdening the body. Pesticides for weed control, chemical fertilizers, and nitrates can be carcinogenic when getting into organism. Automobile exhaust gases, ozone, formaldehyde, wood disinfectants and preservatives, insecticides, paint solvents and the like contaminate air, damage the respiratory tract and weaken the immune system [26]. This is why methods for assessing health risks (e.g. questionnaires, risk assessment, analyses, diagrams, use of geographic information systems) are extremely important. Risk Analysis - [28] states that it is very important to determine the level of danger to human health and animals in a given location and at the same time to take account of future use of a respective area. In general, the principles of the health risk assessment, hazard determination and hazard identification, (evaluation of dose - response relationship, exposure evaluation & assessment, risk characterization are applied). In assessing the health risks and adverse effects of metals, it is important to evaluate not only their presence and overall concentration in the environment and in food, but also their chemical and mineral forms that affect their persistence and bioavailability. The effects of sudden metal uptake into organisms may have the character of “acute disease”. Metals, with regard to the accumulation in target organs of the organism, cause disease manifestations after periods with different length (weeks to years) and the clinical picture has the character of “chronic disease” [11, 29]. The aim of the assessment is to determine the harmfulness of chemicals or other risk factors occurring on the site and to assess whether the substance or risk factor has the ability to damage the body. In general, this part of the risk assessment process describes the quantitative relationship between dose and extent of adverse effect (injury, disease, death). This step requires two basic types of extrapolation using different mathematical models. These are extrapolations - interspecific (experimental animal - human) and extrapolation to the low dose area [10]. At present, the protection of environment is seen as a necessary condition for the existence and further development of human society. It includes activities to prevent pollution or damage to the environment, respectively for the reduction and/or elimination of pollution. It is either general protection (air, soil, water), special protection (protected areas, plants, animals,) or the protection of cultural monuments. The creation of the environment is understood as a purposeful human activity that is organized on a scientific basis, aiming at optimizing the natural and artificial components of the landscape. The aim of environmental care is to maintain or improve its quality with respect to all organisms, while respecting all principles of sustainable living. This environmental care is called environmentalism [7, 13, 30].
4.2 Heavy metals and their importance in environmental pollution, sources, form
Heavy metals are among the common environmental pollutants resulting from both industrial and agricultural production [31]. They are not subject to biological degradation, and their levels are gradually increasing in the individual environmental components: water, air, foodstuffs [29, 32]. They are released into the environment from natural sources (weathering) and by erosion of some minerals and rocks. As stated by [33] the natural increased incidence of heavy metals and other risk elements is mainly in the areas of geochemical anomalies. Regarding pesticides (containing heavy metals), their use has been suspended and is no longer the source of this type of pollution. Metal production (their heat treatment), chemical, engineering, energy production, fossil fuel combustion, waste, food production flushing, fertilization, etc. are among the major anthropogenic sources of environmental pollution. As [34] report, metallurgy of ferrous and non-ferrous ores (the impact of non-ferrous ore metallurgy is predominant in mercury) contributes most to emissions of mercury (Hg), cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu) and zinc (Zn). Combustion of fossil fuels contributes significantly to the emissions of most heavy metals, glass production is a significant source of lead (Pb) and cadmium (Cd) emissions, and transport, despite the dynamic increase in the use of unleaded petrol, complements these sources. In the past, alkyl lead compounds (tetra-ethyl lead) were used as anti-knock additives in gasoline, thereby increasing the concentration of lead in the air. Thus, pollutants are introduced into the environment from various sources and based on their physico-chemical properties. They are transported and participate in biochemical cycles in individual environmental components (air, water, soil, rocks, segments). [35] states that heavy metals constitute one of the most dangerous groups of pollutants. Their amount in the environment is given by content, quantity and movement in all spheres of the environment. The side effects of heavy metal emissions are dangerous, they usually get into the environment (the air) in an uncontrolled way. In the environment, they can occur as simple complexes with inorganic ligands (in the aqueous environment, the form of the metal is affected by physico-chemical properties: pH, temperature, ionic strength), as chelates with organic ligands (sorbed to solid surfaces), free metals. In the terrestrial environment, fate, bioavailability and mobility of metals are influenced by: soil type, oxidation–reduction processes and cationic solid phase capacity [36]. More detailed information on the specific effects of individual heavy metals on cells, tissues, and organs of animals is obtained and validated within laboratory animal experiments. However, the results of the experimental application cannot be considered generally valid. Mostly, the experiment only works with the substance being studied individually, which does not occur alone in the environment. All animal species may not respond to the toxic substance in the same way. In the response of the organism to the action of a toxic substance, the overall momentary state of the organism, its life phase and gender are important. Taking all these factors into account during an experiment is almost impossible. Therefore, despite the systematic research, there is still some concern over formulating the environmental and hazardous concentrations of these substances. However, these doubts do not justify the presence of heavy metals in the environment being taken lightly or underestimated. The combination of overexploitation of natural resources, coercive forced population growth and economic developments, as well as a lack of government regulations can increase the flow of toxic metals into the environment in all countries. By 2010, a significant increase in emissions of mercury (Hg), cadmium (Cd), copper (Cu) and a decrease in lead (Pb) emissions and deposition was expected in Europe [2]. Heavy metals cause a wide range of toxic biochemical effects and thus adversely affect organs and systems in humans and animals [37, 38]. Therefore, they pose a serious risk to health regardless of the source from which they enter the body. Some heavy metals (e.g., manganese, copper, zinc) are needed for physiological processes, but other toxic heavy metals (especially cadmium, mercury, lead) are environmental pollutants [39] and do not have any known physiological roles. Conversely, they may adversely affect health [40] and thus induce a variety of adverse effects including reproductive disorders [41] nutritional deficiencies, endocrine disorders [42, 43] or immunodeficiency disorders; they can induce tumor formation and other health-damaging chronic conditions [32, 44]. Currently, there is also a strong focus on low-dose exposures (environmentally relevant concentrations) of these metals that may affect human and animal reproductive health [3, 45, 46]. Ecologists and environmentalists duly address this issue and take into account the contexts that have not yet been considered. Even if the concentrations of heavy metals with regard to the health safety of living organisms are limited within the monitored areas, environmentalists are the ones drawing attention to many natural processes that cause the concentration of toxic elements to become a real danger. Certain metals are needed for normal body function. They are part of the enzymes and take different roles in metabolic processes and electron transfer - manganese (Mn), copper (Cu), nickel (Ni), molybdenum (Mo), cobalt (Co), iron (Fe), zinc (Zn), however, at higher concentrations they can already become toxic. Heavy metals are characterized by varying degrees of toxicity and different effects on living organisms. The subject of world monitoring is strongly toxic elements - mercury (Hg), cadmium (Cd), lead (Pb), arsenic (As), which have almost no purpose in the organism [47]. Metals are found bound in various inorganic compounds, but can also enter complex organic systems. They are persistent, non-degradable, biologically active with high bioaccumulation potential. They form a natural part of the Earth’s surface composition and therefore occur everywhere in various concentrations. The natural balance of elements is also impaired by human activity. Together with the development of modern technology, production and consumption of metals and metalloids are growing rapidly, too. This is particularly true for non-ferrous metals, some of which have until recently been produced in incomparably lower amounts (e.g. laboratory scale) - beryllium (Be), titanium (Tl) gallium (Ga), selenium (Se), molybdenum (Mo), wolfram (W). Also, the production of classic colored metals which are gradually finding new types of applications, is increasing,. This is especially true for aluminum (Al), lead (Pb), nickel (Ni), chromium (Cr), antimony (Sb), mercury (Hg). Increasing the concentration of the above metals in the environment - air, water, soil and foodstuffs, is a serious hygiene problem and its scale is still becoming larger [23, 34, 48, 49, 50]. In general, metals are highly reactive elements which, on the one hand, are essential (they are components of some enzymes), on the other hand they are capable of damaging different enzymes or interfering with different levels of signal transduction processes in cells.
4.3 Heavy metals and food chain
There is a comprehensive versatile and complex network of food chains in nature. They are interconnected, while the function of the individual elements of the food chains may vary. This causes the symbiotic organism to become dysbiotic, useful changes to harmful, or pathogenic [51]. The common population is also contaminated with the food chain [52] since it has a major impact on human (but also animal) nutrition, lifestyle and life expressions. Animals are much more exposed to the impact of the geochemical environment than humans, as they serve as effective buffers in the nutritional chain, in reducing the adverse effects of the environment on the consumer. According to [53] optimizing the animal nutrition can affect the human food chain. Most heavy metals get into the organism by plant or animal food (the load from air or drinking water is significantly lower). They are converted either into harmless metabolites (detoxification) that are easily excreted, or harmful, reactive products are formed. [54] states that the increased content of especially cadmium (Cd), mercury (Hg), chromium (Cr), arsenic (As), lead (Pb) and nickel (Ni) in agricultural soils may pose a potential risk of contamination of agricultural production. In most countries, including, the applicable legislation determines the maximum permissible concentrations (MPCs) for individual heavy metals (drinking water, air, foodstuffs of plant or animal origin). Therefore, the protection of the food chain from heavy metal contamination, and its follow-up checks are considered to be important in terms of health security. As reported by [55] food safety is a set of measures (animal health and welfare section, food and feed sector) and with their implementation, the safety of all components within the food chain is ensured. According to [56] the occurrence of contaminants in environmental components and in agricultural and food production is monitored through random check-ups and regular monitoring. The relationship between animal health, human health and the environment has been known for a long time. Potential contaminants and their total amount for both veterinary and public health are broad and vary according to their source, chemical nature and mechanism of action on biological systems. [57] state that the prevention of human and animal health from chemical risks implies their control throughout the food chain - field-table. Food quality control with the participation of state health surveillance in the Slovak Republic is one of the essential tasks of food surveillance and the limits of foreign substances in food commodities are harmonized in accordance with the limits of the European Union [58, 59, 60, 61].
4.4 Impact of selected heavy metals-Hg and Cd on humans, animals and the environment
The transport of heavy metals in the atmosphere and their subsequent deposition depends on the following factors: the form in which the metal is found to escape into the atmosphere (solid or gaseous phase), their chemical reaction in the atmosphere, the height and location of the point source of emission, local geographic conditions, speed and direction of wind, rain washing and other meteorological requirements [12]. Pollution of the environment is now a global phenomenon, not excluding the territory of Slovakia and contributes to the deterioration of living and working conditions [2]. Recently, great attention has been paid to the impact of toxic heavy metals and their compounds (especially mercury, cadmium, lead) on human and animal health, which are considered to be dangerous and non-degradable contaminants in the environment. However, a suitable marker for early diagnosis of heavy metal exposure (including drinking water sources) has not yet been developed, which is perceived as a relatively serious problem [62]. As reported by several authors [44, 63, 64] the main consequence of the negative effect of environmental contaminants is the disruption of the optimal immune reactivity of the organism, the occurrence of allergies, increased susceptibility to pathogenic agents, higher occurrence of tumors, affecting reproduction. History shows us a number of global industrial accidents pointing to the negative effects. An important part in creating a good living environment for both humans and livestock is active health creation. It is based on two fundamental phenomena. It is a principle of complexity of measures, respecting variability of the effects of relationships and factors - the internal and external environment of the organism [7].
4.5 Cadmium - sources of cadmium in the environment, the effects of its occurrence
The main sources of cadmium include volcanic activity, weathering of rocks, or forest fires [65]. It gets into the environment by mining and processing of fossil fuels, ferrous and non-ferrous ores, limestone, in cement production [66]. It can be found in Cd-Ni batteries, stabilizers of plastics, home appliances. Cadmium also occurs in synthetic superphosphate and in naturally occurring superphosphates. Cadmium (yellow-orange) paints are added to coatings, gums, textiles, glass and ceramics. Along with zinc (Zn), it occurs in ores and soil at a ratio of 1:100 to 1:1000. It is usually found in the form of cadmium sulfide (CdS) in ores which also contain lead (Pb), zinc (Zn) and copper (Cu). Unlike mercury, it is not subject to biotransformation and cannot be released as an alkyl derivative from the organism. It is now widely used for its anticorrosive effects and serves as a base for electroplating and nickel plating. It is also widely used in making jewelry. It can enter the atmosphere due to poor waste incineration technology (higher cadmium exposure is near the smelter where ores blended with Cd are melted) or oil products [67]. According to WHO, the largest part of cadmium is bound to fine particles (<1 μm) in air, which can then spread up to 1–2 km. Thus, cadmium builds up in soil, water and then enters the food chain. In soil and in some plants, accumulation occurs especially at low soil pH (e.g. leaves, rice). In agricultural soils, the accumulation of cadmium may be associated with the application of (phosphate fertilizers, sewage sludge, some fungicides [66, 68, 69].). The concentration of cadmium in the soil ranges from 0.01 to 0.7 mg.kg−1 and is most cumulative in the 0–5 cm layer. With increasing depth there is a decrease in its concentration. In the process of weathering rocks (content not exceeding 0.3 mg.kg−1), it is easily transformed into a solution and its occurrence is in the form of Cd2+. According to [70], cadmium intake by plants increases with the presence of chlorine in the soil and the content is also significantly affected by soil microorganisms. The way of farming, the time of harvesting the crop and also the environment (climate) affects the cadmium transfer into the plants. This suggests that increased cadmium content in soil is the result of increased cadmium absorption by plants, but, as [71] states, the bioavailability of cadmium also depends on soil solution composition, soil pH, and redox potential. Soil has the ability to somewhat eliminate the negative effects of pollution [22]. Compared to other environmental components, soil status is exceptional. Air and water may move (dilution occurs), and if the source of pollution ceases to be active, there is also a limitation or total elimination of pollution. However, in case of soil contamination by risk elements, we have to realize that this is an irreversible process, it cannot be observed immediately and therefore it is all the more serious. In waters, cadmium accompanies zinc at substantially lower concentrations. According to the higher cadmium content (Cd) has been repeatedly detected in water flowing right by zinc mines. The solubility in water is determined by the solubility of CdCO3 and Cd (OH)2. It is generally presumed that people (but also animals) are the most sensitive cadmium intake group when environment is concerned. The main source of cadmium intake for humans and animals is food, feed and beverages. It is estimated that the average daily dietary intake of cadmium is 50 μg. Up to 25% of the daily intake is retained in the body. The content in dairy products is higher. The lethal dose for oral intake is 350–8900 μg [11]. The impact of the toxic effects of cadmium on the organism: Relative the toxic effect, cadmium is one of the elements that is of great concern for its toxicity and widespread environmental impact. In humans, the main source of Cd exposure is food [72] and the bioavailability of cadmium from food is an important determinant of its potential risk. Cadmium is one of the 10 most toxic substances for human and animal health [39, 73]. Cigarette smoking is also an important source of cadmium accumulation in the body. As reported by author [37] cadmium can cause functional and morphological changes in organs and tissues, and is also strongly neurotoxic. When the exposure to cadmium in environmental components is short term, there may be no health consequences, but from the perspective of long-term exposure (individuals who are more sensitive to toxic effects - infants and children) certain symptoms may occur [70]. The detoxification of the organism is slow (cadmium is characterized by a high accumulation coefficient) and there is a danger of chronic intoxication. Chemically, cadmium is very similar to zinc (it is a part of food), it has an important role for the proper development and health of the organism. However, the similar chemical form of these elements can cause problems as cadmium easily enters various enzymatic reactions instead of zinc, and biochemical processes take place in a different way (e.g., blocking the insulin cycle) and serious health complications occur [3, 74]. Cadmium gets into the organism in three ways: by inhalation, gastrointestinal tract and absorption through the skin. According to WHO, 50–2600 tons of cadmium are emitted annually from natural resources. The atmosphere is polluted by 3300–12,500 tons annually through human activity. In order to eliminate the negative effect on the living organism, [75] recommends a concentration of 5 ng.m−3 as a non-carcinogenic cadmium limit in the air. Current levels in rural areas usually do not exceed 0.4 ng.m−3, and in cities they range from 0.2 to 2.5 ng.m−3. According to in the vicinity of certain industrial agglomerations, this concentration can be significantly higher. WHO has determined a provisional tolerable weekly intake (PTWI) for cadmium at 7 μg.kg−1 of body weight. Since food is a major source of cadmium for most of the population, attention has also been paid to its quality as well as to the reduction of cadmium contamination of the environment. With an average absorption of about 5% of the amount received, about 0.5–1 μg of cadmium is retained daily in the organism. Based on epidemiological studies, there has been an increase in lung cancer and prostate cancer in long-term cadmium inhalation. In hazardous operations, inhalation intake is currently strictly controlled. The human lethal dose is 0.3–8.9 g. IARC [100] (International Agency for Research on Cancer) classifies Cd as the first category carcinogen for humans and animals.
4.6 Mercury - sources of mercury in the environment, the effects of mercury
Mercury is commonly found in the natural environment as it is a part of the Earth’s crust. Its origin can be geogenic and anthropogenic. Mercury gets into the environment during its production and processing of products (production of electrodes, electrical equipment, dyes, measuring and control equipment, use in dentistry, chemical laboratories, etc.). In a year, this is estimated at 10,000–30,000 tons of mercury; and it gets into the environment by evaporating from the surface of the Earth and the oceans (vapor of metallic mercury, volatile organic compounds), [48]. The conversion of mercury (present in the form of ions) in a volatile form can theoretically occur in three ways: by chemical reaction to elemental mercury (not previously found in nature), by reduction to elemental mercury by microorganisms, plants, animals, and by biotransformation to more volatile organo-mercury compounds (alkyl compounds), [76]. According to the most recent data, 5207 × 106 g of mercury is released from the natural sources annually into the atmosphere, and 2909 × 106 g (total 8116 × 106 g) of mercury from anthropogenic sources. The main anthropogenic sources by which mercury enters the atmosphere is the combustion of fossil fuels (1422 × 106 g.year−1), gold mining (400 × 106 g.year−1), waste management (187 × 106 g.year−1), production of non-ferrous metals (310 × 106 g.year−1), cement production (236 × 106 g.year−1) [34, 77]. Global mercury emissions from natural resources are estimated at 3.0 × 106 g.year−1. The average mercury (Hg) content in the Earth’s crust is about 0.067 ppm. Air, water, soil - elemental mercury vapors released from the Earth’s crust rise to the atmosphere (amount of about 18 mg.m−3), where they are oxidized to divalent mercury and from there the compounds get into the water reservoirs by rain. Divalent mercury in the sediments at the bottom of the seas and lakes is methylated to methyl mercury by the action of microorganisms. It enters the food chain - phytoplankton - zooplankton - small fish - big fish. At the top of this chain are animals (that feed on fish), including humans. Within this chain, the process of bioaccumulation of ethylmercury occurs. As reported by [11, 78], its concentration is gradually increasing, with the values at the top of the chain about a million times higher than the concentration of methylmercury in the surrounding water. In general, large and longer-living fish (shark, tuna, mackerel, pike) also contain more mercury [48, 79, 80]. Under “European Commission Decision 93/351”, the value of Hg in the meat of fish living in relatively uncontaminated areas should be below 0.5 gg−1.The concentration of mercury in the air ranges from 1 to 5 mg.m−3 in rural areas and 7–10 mg.m−3 in cities. The enrichment of soils with mercury is caused by the burning of coal, the occurrence of cinnabar deposits, but also by applying mercury-based fungicides. The use of sewage and urban sludge and fertilizers is also a source of mercury soil pollution. However, this is not just about soil contamination, but also about secondary effect on vegetation growing on it [81]. Mercury gets into the soil in the range of 0.02–03 mg.kg−1. The concentration of mercury in uncontaminated soils should be within the range of 0.02–0.2 mg.kg−1 [82]. Average concentrations affected by human activity are in the range of 0.1–0.4 mg.kg−1, and in the vicinity of industrial enterprises and crematoria up to 1.8 mg.kg−1, in the third of Slovakia’s territory the content of total mercury is higher in woody plants (the value exceeds 0.12 mg.kg−1) [11, 83, 84]. The natural content in the soil is from several, up to tens of μg.kg−1. The use of mercury and its compounds has spread rapidly, and this fact cannot remain without consequences for: the environment, living organisms, including humans and animals. Therefore it is important to create favorable living conditions also for livestock (active health creation) based on the fundamental phenomena - complexity of measures and respect for the variability of the effects of relationships and factors between the internal and external environment [7]. Effects of toxic action of mercury on the organism: Regarding the effects of toxic effects on the organism, mercury is given a relatively high attention. Its toxicity depends on the physical properties of the individual forms. However, there are differences among them, based on the way of exposure, the metabolism itself, the way of excretion. It is known that the more mobile the form of mercury is, the more toxic it becomes. These properties are due to the structure of the molecule (e.g., behavior in biosystems, stability, excretion rates, etc.) [49, 85]. The negative impact not only on the health of people but also on the health and the performance of the animals results from an increased incidence of mercury, especially in polluted areas. The hygienic quality of animal products is lower, the content of toxic elements in meat and dairy products is higher and the reproductive and growth indicators get reduced [9, 86]. Mercury is the world’s only liquid metal that gets into the body most often by inhalation of mercury vapor, and up to 80% of these is absorbed in the lungs. The absorption of elemental mercury in the GIT is very low, less than 1%. [87] report that compounds containing divalent mercury are absorbed in GIT more, even up to 10%. Further, it is taken into consideration that oral administration may be accidental, or in contact with skin. As stated by [88], this metal has a high affinity for phosphates, cysteine and histidinyl side chains of proteins, but also for purines, porphyrins and pteridines. Mercury, along with its compounds, is one of the high-toxic poisons (5 times more toxic than lead). The harmful daily human dose is 0.4 mg, the lethal dose is 150–300 mg. The condition of its toxic effect is the oxidation of Hg0 to Hg1+ up to Hg2+. After oxidation, Hg2+ binds to -SH groups of proteins, which are thereby inactivated. Upon absorption, a large proportion of mercury (depending on the type of compound and the site of absorption) gets into circulation. A part enters the erythrocytes and another part binds to the ligands in the plasma. The ratio of mercury content in plasma and in erythrocytes is about 1: 1. In erythrocytes, mercury (Hg) binds to the -SH group of hemoglobin. Elemental mercury (e.g. in mercury vapor poisoning) is oxidized to divalent cation. In plasma, mercury binds to albumin and other plasma proteins that contain free -SH groups. Exposure to mercury increases the amount of metallothionein (low molecular weight protein), which to some extent prevents kidney damage [11, 89, 90]. Elemental mercury and some of its organic compounds easily cross membranes (e.g., the erythrocyte membrane) and, unlike some other heavy metals (e.g. cadmium), easily cross the placental blood–brain barrier, too. In the complex with glutathione it is excreted in the bile, but it also reaches the sweat, salivary and dairy glands. In humans, the mean half-life of excretion for inorganic mercury is 60 days, for alkyl compounds of mercury 70 days [73]. The kidneys are the site of the greatest accumulation of mercury and also the major site of its excretion. There are several hypotheses explaining the mechanism of mercury excretion in the kidneys. One of them is the hypothesis that part of it gets into the urine in binding to albumin and then is reabsorbed (by endocytosis) in the proximal tubule. Another part is excreted in binding to glutathione, which is, similar to bile, hydrolyzed to amino acids by γ-glutamyltransferase and dipeptidases, and such amino acids are then reabsorbed by the Na-dependent transport system [91]. Mercury is excreted in the feces and urine. For inorganic mercury, the excretion half-life (both acute and chronic) is 1–3 months, for methylmercury it is 50 days. Since methylmercury permeates the hair, the level is used as a marker of mercury exposure [11, 92]. Food that has been contaminated with methylmercury (especially fish) are among the most common sources of exposure to organic mercury. At the end of the 19th century, [93] described the so-called pink disease (acrodynia - sporadic and predominant pediatric syndrome associated with calomel in toothpaste and other forms of inorganic mercury) related to an allergic reaction in hypersensitive people. Abnormal reddening of the skin has occurred, as well as peeling of the skin (area of the hands, legs, feet), pain threshold reduction, swelling. Acrodynia has been found in infants but also in older children who have used diapers treated with phenylmercury (an organic form of mercury). In spite of the scientifically-based study, mercury is still a part of various cosmetics and pharmaceutical compositions. However, it should be noted that the skin reactions to mercury are relatively rare, even scarce. The concentration of mercury in the blood in the general population (the result of dietary intake) is mainly in the form of organic compounds, but it is present in the urine mainly in inorganic form. Why this is the case (difference in form) yet needs to be further explored in mammals. As reported by [94], mercury concentration in blood increases with fish consumption. However, larger areas of amalgam fillers, which may be the source of increased urinary excretion, also need to be considered. Other so-called immunotoxic responses can also be induced when exposed to inorganic mercury - Kawasaki disease, rash, cracking of the lips, fever, photophobia, pharyngitis, peeling of the skin on the palms of the hands and feet, tachycardia, affection of the lymphatic tissue - these are symptoms afflicted by sufferers. Urine levels of mercury have been shown to be higher in the affected patients. [93] reports that infants but also older children have more sensitive organisms than adults, and that explains the higher absorption of inorganic mercury. Among the organic mercury compounds, thiomersal (thimerosal, mertiolate, sodium ethylmercurithiosalicylate) is known as being used as a preservative in childhood vaccination since the 1930s. The thiomersal composition is 49.6 wt% Hg - it is metabolized to EtHg and thiosalicylate. The vaccine dose for children contains about 2.5 mg Hg in 0.5 ml. [95, 96] have expressed concern that the developing CNS could be harmed in children in the first half year of life. Possible health consequences: delayed speech development, impaired concentration, local hypersensitive responses, the spectrum of autism disorders. With long-term administration of gamma globulin (containing thiomersal), acrodynia has occasionally been confirmed. Based on these findings, thiomersal was requested to be removed from vaccines. However, it continues to be used in some countries to these days. According to [97] at high doses of EtHg the undesirable effects are similar to high doses of MeHg. However, the effect of low dose of EtHg remains unclear, more recent data [98] describe EtHg to be less neurotoxic than MeHg. The effects of mercury on health depend on several factors (form, dose, duration of exposure). International organizations Health Care Without Harm and the Health & Environment Alliance advocate accelerated reduction of environmental pollution by mercury in the European Union as well as worldwide and raise awareness of its destructive impact on the human fetal brain (arises during the early development of the fetus by methylmercury). It has a damaging effect on the development of the nervous system, and such damage is mostly irreversible. [99] states that the source of intense interest in the scientific community is primarily three chemical forms as a source of exposure: methyl mercury in fish, mercury vapor from amalgam dental fillings, and ethyl mercury in vaccines. US EPA (Environmental Protection Agency) classifies inorganic mercury into Group D “substances that do not have carcinogenic effects on humans” but [100] is considering reviewing the inclusion of inorganic mercury according to EPA. Organic forms of mercury - methyl mercury and its compounds are, according to IARC, rated as possible carcinogens [63].
5. Conclusion
Population health, as a universal value and primary human rights, is a fundamental economic resource not only for the individual but also for the whole of society. One of the main starting points for solving the relationship between man and the environment is the planned nature protection. The environment is everything that creates natural conditions for the existence of organisms, including humans, and is a prerequisite for their further development. The work was supported by VEGA 2/0125/17.
\n',keywords:"environment, heavy metals – Cd, Hg, risks of environmental pollution, food chain, health",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/69435.pdf",chapterXML:"https://mts.intechopen.com/source/xml/69435.xml",downloadPdfUrl:"/chapter/pdf-download/69435",previewPdfUrl:"/chapter/pdf-preview/69435",totalDownloads:473,totalViews:0,totalCrossrefCites:1,dateSubmitted:"March 15th 2019",dateReviewed:"May 15th 2019",datePrePublished:"October 8th 2019",datePublished:"August 19th 2020",dateFinished:"October 8th 2019",readingETA:"0",abstract:"Global environmental contamination is one of the most significant environmental problems in contemporary society. Pollutants are entering the environment from different sources, and on the basis of their physico-chemical properties, they are transported and participate in biochemical cycles in the varied components of the environment, namely in the air, aquatic environment, soil and in rocks or segments. They enter the food chain through which they enter the human body, where they are transformed into either harmless metabolites (detoxification) that are easily excluded or else harmful, reactive products are formed. Heavy metals are one of the most dangerous groups of biologically important pollutants. The burden of the environment puts more significant burden on populations and ecosystems. They form integrant part of the earth’s surface and therefore are present throughout the land. We can utter that contamination of the environment and its consequences for living organisms have long been in forefront of the interest in scientific as well as lay community.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/69435",risUrl:"/chapter/ris/69435",signatures:"Iveta Cimboláková, Ivan Uher, Katarína Veszelits Laktičová, Mária Vargová, Tatiana Kimáková and Ingrid Papajová",book:{id:"8831",title:"Environmental Factors Affecting Human Health",subtitle:null,fullTitle:"Environmental Factors Affecting Human Health",slug:"environmental-factors-affecting-human-health",publishedDate:"August 19th 2020",bookSignature:"Ivan Uher",coverURL:"https://cdn.intechopen.com/books/images_new/8831.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"227237",title:"Prof.",name:"Ivan",middleName:null,surname:"Uher",slug:"ivan-uher",fullName:"Ivan Uher"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Atmosphere",level:"1"},{id:"sec_3",title:"3. Hydrosphere",level:"1"},{id:"sec_3_2",title:"3.1 Division of water by origin, pollution, causes",level:"2"},{id:"sec_5",title:"4. Pedospere",level:"1"},{id:"sec_5_2",title:"4.1 Health risks of environmental pollution, risk analysis, evaluation",level:"2"},{id:"sec_6_2",title:"4.2 Heavy metals and their importance in environmental pollution, sources, form",level:"2"},{id:"sec_7_2",title:"4.3 Heavy metals and food chain",level:"2"},{id:"sec_8_2",title:"4.4 Impact of selected heavy metals-Hg and Cd on humans, animals and the environment",level:"2"},{id:"sec_9_2",title:"4.5 Cadmium - sources of cadmium in the environment, the effects of its occurrence",level:"2"},{id:"sec_10_2",title:"4.6 Mercury - sources of mercury in the environment, the effects of mercury",level:"2"},{id:"sec_12",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Kontrišová O. 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Toxic trace metals and human oocytes during in vitro fertilization (IVF). Reproductive Toxicology. 2010:298-305'},{id:"B46",body:'Slivkova J, Massanyi P, Pizzi F, Trandzik J, Roychoudry S, Lukač N, et al. In vitro toxicity of mercuric chloride on rabbit spermatoza motility and cell membrane integrity. Journal Environtal Science Health A. 2010;45:767-774'},{id:"B47",body:'Babčan, J, Khun M, Sevc J. Toxicita ťažkých kovov - životné prostredie. Životné prostredie, revue pre teóriu a tvorbu ŽP. SAV Bratislava. vol. 5. 1999. pp. 1-5. ISBN 80-228-0869-5'},{id:"B48",body:'Bencko V et al. Hygiena. Praha; ČR: Nakladatelství Karolinum Praha; 2002. 205 p. ISBN 80-7184-551-5'},{id:"B49",body:'Bencko V, Cikrt M, Lener J. Toxické kovy v pracovním a životním prostředí člověka. Praha: Avicenum, zdravotnické nakladatelství; 1985. p. 264. ISBN 80-7169-150-x'},{id:"B50",body:'Singh VK, Mishra KP, Rani R, Yaday VS, Awasthi SK, Garg SK. Immunomodulation by lead. Immunologic Research. 2003;28:151-166'},{id:"B51",body:'Zachar D. Výživa človeka I. Zvolen: TU, 2008. 328p. ISBN 80-85617-56-0'},{id:"B52",body:'CDC (Centers for Disease Control and Prevention). Fourth National Report on Human Exposure to Environmental Chemicals2009. pp. 176-242. ISBN 978-0-520-07107-0'},{id:"B53",body:'Jesenská M, Hiščáková M, Novotný J, Link R, Kováč G. Koncentrácia olova v krvnom sere mlieku a moči dojníc. In: Rizikové factory potravového reťazca III. Nitra, SP. 2003. pp. 51-52. ISBN 80-8069-282-3'},{id:"B54",body:'Adriano DC. Trace Elements in Terrestial Environments. 2nd ed. Springer; 2001. pp. 263-677. ISBN 0-387-98678-2'},{id:"B55",body:'Sinclair R, Boone SA, Greenberg D, Keim P, Gerba CHP. Persistence of category a slelect agents in the environment. Applied and Environmental Microbiology. 2008;74:555-663'},{id:"B56",body:'Ganga M. Hettiarachchi: Bioavailability, toxicity, and risk relationships in ecosystems. 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Cancer Investigation. 2005;23:256-263'},{id:"B68",body:'Al-Najar H, Schulz R, Breuer J, Roemheld V. Effect of cropping systems on the mobilityand uptake of Cd and Zn. Environmental Chemistry Letters. 2005;3:13-17'},{id:"B69",body:'Kabata-Pendias A, Pendias H. Trace Elements in Soils and Plants. 3th ed. CRC Press; 2000. pp. 143-154. ISBN 978-1-4200-3990-0'},{id:"B70",body:'Šalgovičová D. Hodnotenie expozície kadmiom v podmienkach Slovenskej republiky: výskumná správa; 2009, pp. 1-31'},{id:"B71",body:'Richter R. Živinný režim rúd - ťežké kovy v púde. MZLU Brno: Ústav agrochemie a výživy rostlín; 2004. pp. 156-165'},{id:"B72",body:'EFSA (European Food Safety Authority). Cadmium in food. The EFSA Journal. 2009;980:1-139'},{id:"B73",body:'ATSDR (Agency for Toxic Substances and Disease Registry). Toxicological Profile for Mercury. U.S. Department of Health and Human Services; 1999. pp. 1-676. ISBN 1-888-422-8737'},{id:"B74",body:'Hayes W. Principles and Methods of Toxicology. Vol. 33. CRC Press; 2007. pp. 858-861. ISBN 9780849337789'},{id:"B75",body:'WHO. Air Quality Guidelines for Europe, 2000'},{id:"B76",body:'Křištofová D. Kovy a životní prostředí. Environmentálně nebezpečné složky elektroodpadu. 1st ed. Ostrava: VŠB-TU Ostrava; 2005. p. 66. ISBN 80-248-0740-8'},{id:"B77",body:'Issaro N, Abi-Ghanen C, Bermond A. Fractionation studies ofmercury in soils and sediments: A review of the chemical reagents used for mercury extraction. Analytica Chimica Acta. 2009;631(1):1-12'},{id:"B78",body:'Urban P. Aktuální problémy neurotoxicity rtuti. Neurológia pre Prax. 2006;5:251-253'},{id:"B79",body:'UNEP IOMC. United Ntions Environment Programme-Chemicals: Global Mercury Assessment. Inter- Organization Programme for the Sound Management of Chemicals. Ženeva; 2002. 258 p'},{id:"B80",body:'WHO. Environmental Health Criteria 86: Mercury – Environmental Aspects. Geneva; Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. ISBN 92-415-4286-1. 1989; 115 p'},{id:"B81",body:'Ďurža O, Khun M. Environmentálna geochémia niektorých ťažkých kovov. UK: Bratislava; 2002. 116 p. ISBN 80 223 1657 1'},{id:"B82",body:'Velíšek J. Chemie potravin 2.1. OSSIS: Pelhřimov; 1999. 328 p. ISBN 80-902391-4-5'},{id:"B83",body:'Kimáková T, Bernasovská K. Zaťaženie životného prostredia ortuťou na priemyselne exponovanom území Slovenska. Slovenský veterinársky časopis. 2005;30(6):369-370'},{id:"B84",body:'Mari M, Domingo JL. Toxic emission from crematories: A review. Environment International. 2010;36(1):131-137'},{id:"B85",body:'Tichý M. Toxikoloógie pro chemiky. Toxikoógie obecná, speciální, analytická a legislatíva. Praha: Karolinum; 2003, 2003. 119 p. ISBN 80-246-0566-X'},{id:"B86",body:'Kimáková T, Bernasovská K. Sledovanie koncentrácie ortuti vo vybraných potravinách. In: Využitie chemických metód pri ochrane a podpore zdravia obyvateľstva. Košice: UPJŠ; 2008. pp. 38-43. ISBN 9788070977279'},{id:"B87",body:'Gerhardsson L, Skerfving S. Concepts on biological markers and biomonitoring for metal toxicity. In: Chang LW, Magos L, Suzuki T, editors. Toxicology of Metals. USA: CRC Press. Inc; 1996. pp. 81-107'},{id:"B88",body:'Pískač A, Kačmár P, Kol A. Veterinární toxikológie. Živočíšna výroba: Státní zemědelské nakladatelství v Praze ve spolupráci s nakladatelstvím Príroda v Brateslavě ve sbírce; 1985. p. 256. ISBN 80-7148-022-3'},{id:"B89",body:'Guzzi G, La Porta CA. Molecular mechanisms triggered by mercury. Toxicology. 2008;244(1):1-12'},{id:"B90",body:'Aschner M, Onishchenko N, Ceccatelli S. Toxicology of alkyl-mercury compuounds. In: Metal Ions Life Sciences. Vol. 7. 2010. pp. 403-434. ISBN 978-1-84755-177-1'},{id:"B91",body:'Ariza ME, Bijur GN, Williams MV. Lead and mercury mutagenesis: Role of H2O2, superoxide dismutase, and xanthine oxidase. Environmental and Molecular Mutagenesis. 1998;31:352-361'},{id:"B92",body:'Myers GJ, Davidson PW, Cox C, Shamlaye C, Cernichiari E, Clarkson TW. Twenty-seven years studying the human neurotoxicity of methylmercury exposure. Environmental Research. 2000;83(3):275-285'},{id:"B93",body:'Clarkson TW. The three modern faces of mercury. Environmental Health Perspectives. 2002;110:11-23'},{id:"B94",body:'Schober SE, Sinks TH, Jones RL, Bolger PM, Mcdowell M, Osterloh J. Blood mercury levels in US children and women of childbearing age, 1999-2000. JAMA. 2003;289(13):1667-1674'},{id:"B95",body:'AAP & USPHS. Joint statement of the American Academy of Pediatrics and the United States Public Health Service. Pediatrics. 1999;104:568-569'},{id:"B96",body:'USPHS - US Public Health Service, 1999. ISBN 05-20253-76-0'},{id:"B97",body:'Ball LK, Ball R, Pratt RD. An assessment of thimerosal use in childhood vaccines. Pediatrics. 2001;107(5):1147-1154'},{id:"B98",body:'Magos L. Review on the toxicity of ethylmercury, including its presence as a preservative in biological and pharmaceutical products. Journal of Applied Toxicology. 2001;21(1):1-5'},{id:"B99",body:'Tuček M. Současná zdravotní rizika expozice rtuti a jejim sloučeninám. České pracovní lékařství. 2006;7(1):26-34'},{id:"B100",body:'IARC (International Agency for Research on Cancer). Cadmium and cadmium compounds. Berylium, cadmium, mercury, and exposures in the glass manufacturing industry. In: IARC Monographs on the Evalution of Carcnogenetic Risks to Humans. Vol. 58. 1993, 1993. pp. 119-237'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Iveta Cimboláková",address:"iveta.cimbolakova@upjs.sk",affiliation:'
Slovak Academy of Science, Department of Environmental and Plant Parasitology, Slovak Republic
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A Case Study: Illumination of the Facade of Santiago Hospital in Úbeda (Jaén)",slug:"control-systems-and-ornamental-lighting-a-case-study-illumination-of-the-facade-of-santiago-hospital",abstract:"We propose the analysis of the control systems associated with ornamental lighting applied to the architectural and monumental heritage from our teaching experience developed since 2017 at the University of Córdoba—Illumination Faculty of Philosophy of Córdoba, year 2017, and Center of Experimental Culture in the Plaza de la Corredera, year 2018—and the lighting project of the facade of the Hospital de Santiago de Úbeda, Jaén. The DMX system is the one which mostly fulfill the requirements of this kind of lighting. Its implementation is increasingly simple and is associated in many cases with the type of luminaire to be used and the particularity of differential wiring. This solution allows a personalized, creative, and dynamic control and the adaptation of the daily lighting to different events of singular character. It can be used as an instrument of economic revitalization of the tourist and commercial sectors, and of diffusion of the architectural and historical heritage values. The application of the Internet of Things (IoT) and Big Data could allow the creation of a predictive model that helps the spectral design of light sources and an objective tool that contributes to the confluence of art and science.",signatures:"Juan Cantizani Oliva, Eduardo Ruiz Vela and José Zamora Salido",authors:[{id:"309595",title:"Prof.",name:"Juan",surname:"Cantizani Oliva",fullName:"Juan Cantizani Oliva",slug:"juan-cantizani-oliva",email:"p02caolj@uco.es"},{id:"309714",title:"Prof.",name:"Eduardo",surname:"Ruíz Vela",fullName:"Eduardo Ruíz Vela",slug:"eduardo-ruiz-vela",email:"el1ruvee@uco.es"},{id:"309715",title:"Prof.",name:"José",surname:"Zamora Salido",fullName:"José Zamora Salido",slug:"jose-zamora-salido",email:"el1zasaj@uco.es"}],book:{title:"Energy Efficiency and Sustainable Lighting",slug:"energy-efficiency-and-sustainable-lighting-a-bet-for-the-future",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"289346",title:"Dr.",name:"Rowan",surname:"Machaka",slug:"rowan-machaka",fullName:"Rowan Machaka",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"294306",title:"Dr.",name:"Mudrite",surname:"Daugaviete",slug:"mudrite-daugaviete",fullName:"Mudrite Daugaviete",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:null,institutionString:null,institution:null},{id:"294307",title:"Dr.",name:"Baiba",surname:"Bambe",slug:"baiba-bambe",fullName:"Baiba Bambe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"295016",title:"Dr.",name:"Dagnija",surname:"Lazdina",slug:"dagnija-lazdina",fullName:"Dagnija Lazdina",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"295017",title:"Dr.",name:"Andis",surname:"Lazdins",slug:"andis-lazdins",fullName:"Andis Lazdins",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"305713",title:"Dr.",name:"Olfa",surname:"Bel Hadj Brahim Kechiche",slug:"olfa-bel-hadj-brahim-kechiche",fullName:"Olfa Bel Hadj Brahim Kechiche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:"Olfa Bel Hadj Brahim Kechiche received a Bachelor of science degree in\r\nelectrical engineering from the Higher School of Technology and Computer\r\nScience - Carthage University (ESTIC), Tunis, Tunisia, in 2006, a Master of\r\nscience degree in electrical systems in 2008 and a doctorate degree in electrical\r\nengineering in 2014 from the National Engineering School of Tunis (ENIT) -\r\nTunis El Manar University. She is currently an Assistant Professor in the\r\nElectronics and Computer Science Department of the higher school of Sciences\r\nand technology of Hammam Sousse (ESSTHS), Tunisia, and Permanent\r\nresearcher in the Laboratory of Energy and Materials (LR11ES34) of ESSTHS.\r\nHer research interests include sensorless control of Permanent Magnet\r\nSynchronous Machines and Performance improvement of the Concentration\r\nPhotovoltaic systems (CPV).",institutionString:null,institution:{name:"University of Sousse",institutionURL:null,country:{name:"Tunisia"}}},{id:"307298",title:"Ph.D. Student",name:"Nancy",surname:"Varela",slug:"nancy-varela",fullName:"Nancy Varela",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:null,institutionString:null,institution:{name:"Catholic University of Santiago de Guayaquil",institutionURL:null,country:{name:"Ecuador"}}},{id:"309479",title:"Mrs.",name:"Marwa",surname:"Hamza",slug:"marwa-hamza",fullName:"Marwa Hamza",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"309480",title:"Prof.",name:"Habib",surname:"Sammouda",slug:"habib-sammouda",fullName:"Habib Sammouda",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"310019",title:"Dr.",name:"Daniel",surname:"Espinoza Díaz",slug:"daniel-espinoza-diaz",fullName:"Daniel Espinoza Díaz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310019/images/13100_n.jpg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"authorship-policy",title:"Authorship Policy",intro:'
',metaTitle:"Authorship Policy",metaDescription:"IN TECH's Authorship Policy is based on ICMJE criteria for authorship. In order to be identified as an Author, one must:",metaKeywords:null,canonicalURL:"/page/authorship-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"
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Substantially contribute to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work
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Participate in drafting or revising the work
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Approve the final version of the work to be published.
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All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
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CHANGES IN AUTHORSHIP
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If it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
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AFFILIATION
\\n\\n
Authors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
Substantially contribute to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work
\n\t
Participate in drafting or revising the work
\n\t
Approve the final version of the work to be published.
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\n\n
All contributors who meet these criteria are listed as Authors. Their exact contributions should be described in the manuscript at the time of submission.
\n\n
Conversely, all contributors who do not meet these criteria should be listed in the Acknowledgments section of the manuscript, along with a short description of their specific contributions.
\n\n
CHANGES IN AUTHORSHIP
\n\n
If it is felt necessary to make changes to the list of Authors after a manuscript has been submitted or published, it is the responsibility of the Author concerned to provide a valid reason to amend the published list. Additionally, all listed Authors must verify and approve the proposed changes in order for any amendments to be made.
\n\n
AFFILIATION
\n\n
Authors are responsible for ensuring all addresses and emails provided are correct. Under affiliation(s) all Authors should indicate where the research was conducted. Please note that no changes to the affiliation(s) can be made after the chapter has been published.
\n\n
Policy last updated: 2017-05-29
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/54719/images/system/54719.jpg",biography:"Prof. Hany A. El-Shemy received his two PhD degrees in Biochemistry and Genetic Engineering from the University of Cairo, Egypt and University of Hiroshima, Japan. He became an assistant professor in the Biochemistry Department of Cairo University, Egypt, from Sept. 1996 and advanced to associate professor in Sept. 2002 as well as a full professor in March 2007. His research interests are in the fields of plant biotechnology and medicinal plants (Molecular Biology). He registered 2 patents, wrote 12 international books, published more than 90 SCI journal papers and 45 conference presentations, and served as the technique committee member as well as chair in many international conferences and the editor in BMC Genomics as well as in Current Issues in Molecular Biology, and also a reviewer for more than 25 SCI cited journals. He received several awards, including State Prize awarded from the Academy of Science, Egypt (2004); Young Arab Researcher Prize awarded from Schuman Foundation, Jordan (2005); State Excellence Prize from the Academy of Science, Egypt (2011 and 2018); and Cairo University Prizes (2007, 2010, and 2014). He served as an expert for African Regional Center for Technology, Dakar, Senegal, plus a visiting professor at Pan African University, African Union, Nairobi, Kenya. He was appointed acting vice president of the Academy of Science and Technology from November 2013 to November 2014, Egypt. He was also a dean of the Faculty of Agriculture, Cairo University from 2014 to 2017.",institutionString:"Cairo University",institution:{name:"Cairo University",country:{name:"Egypt"}}},{id:"93369",title:"Dr.",name:"Yves",middleName:null,surname:"Gibon",slug:"yves-gibon",fullName:"Yves Gibon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Institut National de la Recherche Agronomique",country:{name:"Morocco"}}},{id:"105746",title:"Dr.",name:"A.W.M.M.",middleName:null,surname:"Koopman-van Gemert",slug:"a.w.m.m.-koopman-van-gemert",fullName:"A.W.M.M. Koopman-van Gemert",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/105746/images/5803_n.jpg",biography:"Dr. Anna Wilhelmina Margaretha Maria Koopman-van Gemert MD, PhD, became anaesthesiologist-intensivist from the Radboud University Nijmegen (the Netherlands) in 1987. She worked for a couple of years also as a blood bank director in Nijmegen and introduced in the Netherlands the Cell Saver and blood transfusion alternatives. She performed research in perioperative autotransfusion and obtained the degree of PhD in 1993 publishing Peri-operative autotransfusion by means of a blood cell separator.\nBlood transfusion had her special interest being the president of the Haemovigilance Chamber TRIP and performing several tasks in local and national blood bank and anticoagulant-blood transfusion guidelines committees. Currently, she is working as an associate professor and up till recently was the dean at the Albert Schweitzer Hospital Dordrecht. 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