Chemical structures of major polyphenols (flavonoids: flavanols and flavonols) in Green tea and Black tea.
\r\n\t
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Dr. Tiefenbacher has published more than 200 papers on a diverse array of topics that examine perception and behaviors with regards to the application of pesticides, releases of toxic chemicals, environments of the U.S.-Mexico borderlands, wildlife hazards, and the geography of wine.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"73876",title:"Dr.",name:"John P.",middleName:null,surname:"Tiefenbacher",slug:"john-p.-tiefenbacher",fullName:"John P. Tiefenbacher",profilePictureURL:"https://mts.intechopen.com/storage/users/73876/images/system/73876.jfif",biography:"Dr. John P. Tiefenbacher (Ph.D., Rutgers, 1992) is a professor of Geography at Texas State University. His research has focused on various aspects of hazards and environmental management. 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More recently his work pertains to spatial adaptation to climate change, spatial responses in wine growing regions to climate change, the geographies of viticulture and wine, artificial intelligence and machine learning to predict patterns of natural processes and hazards, historical ethnic enclaves in American cities and regions, and environmental adaptations of 19th century European immigrants to North America's landscapes.",institutionString:"Texas State University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Texas State University",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"12",title:"Environmental Sciences",slug:"environmental-sciences"}],chapters:[{id:"76073",title:"Integrating Ecological Site Descriptions with Soil Morphology to Optimize Forest Management: Three Missouri Case Studies",slug:"integrating-ecological-site-descriptions-with-soil-morphology-to-optimize-forest-management-three-mi",totalDownloads:24,totalCrossrefCites:0,authors:[{id:"185895",title:"Dr.",name:"Michael",surname:"Aide",slug:"michael-aide",fullName:"Michael Aide"},{id:"269286",title:"Dr.",name:"Christine",surname:"Aide",slug:"christine-aide",fullName:"Christine Aide"},{id:"269287",title:"Dr.",name:"Indi",surname:"Braden",slug:"indi-braden",fullName:"Indi Braden"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"194667",firstName:"Marijana",lastName:"Francetic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/194667/images/4752_n.jpg",email:"marijana@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"67160",title:"Aortic Root Reconstruction",doi:"10.5772/intechopen.86034",slug:"aortic-root-reconstruction",body:'The technique of aortic root surgery has undergone many improvements during the past decades. These are a direct result of better understanding of the functional hemodynamics of the aortic root coupled with significant improvement in imaging. We present here a brief overview of pathology involving the aortic root with a special focus on the surgical aspects in these operative procedures. Our chapter includes tips on use of mechanical valve conduits, homograft, and stent-less valve prostheses as well as techniques implementing a valve-sparing approach.
Improved imaging and computer simulation has increased our understanding of the aortic root anatomy, structure and function. Aortic root had been described as the vascular tube supporting the aortic valve leaflets and connecting the left ventricular outflow tract inferiorly to the sinotubular junction superiorly [1]. Two thirds of the lower segment (aortic annulus) of the aortic root is attached to the interventricular septum while the remainder is attached to the fibrous part of the anterior mitral valve leaflet [2]. This tubular structure (Figure 1) encompasses the aortic valve leaflets, coronary ostia, commissures, interleaflet triangles and the sinuses [1]. All these components link together to act as a single unit. It is now clear, that this is much more than just a passive unit governed by pressure changes across the valve [3, 4]. The geometric relationship of the valve leaflets as well as individual lengths are important for it to work as a single efficient hemodynamic unit [5].
Opened aortic root section. Sinotubular junction is indicated by the open arrows, small arrows indicating the coronary ostia (left and right), broken lines indicating the fibrous skeleton between the aortic and mitral valves. L, R, and N mark the left, right and the non-coronary cusps, respectively [
The dilated portion of the aortic wall between the aortic annulus and sino-tubular junction is known as the sinus of Valsalva. These sinuses are named according to the relationship of the origin of the coronary ostia from the root that is left, right or non-coronary sinuses. The sinuses are labelled corresponding to their coronary ostia. One of the important roles provided by these sinuses is preventing obstruction of the coronary ostia during movement of the aortic valve leaflets against the aortic wall, so that coronary blood flow is maintained [5]. An important function is prevention of ostial obstruction during systole when the aortic valve is open [7]. Generation of Eddy currents during early systole prevents the aortic leaflets from touching the aortic wall [8].
The aortic valve leaflets which are inserted at their bases in a semilunar fashion to the aortic annulus. They allow uni-directional flow of blood from the left ventricle to the aorta. Aortic valve leaflets are variable in size and number, the non-coronary cusp being the largest compared to the left or right aortic valve cusps. The most common variation is the bicuspid aortic valve, which consists of a semi-lunar opening due to the presence of two leaflets, and the commonest deviation from the normal tri-leaflet pattern is the known congenital anomaly called bicuspid aortic valve [9]. The attachment of the curved aortic valve leaflets form the triangular space named as the interleaflet triangles, the apices of these triangles is known as the valve commissures which are at the level of the sinotubular junction [10]. Aortic valve competence depends on the overlap between these adjacent free margins of the leaflets.
The aortic valve annulus represents the ventriculo-aortic junction which is a complex structure and universally accepted term as aortic annulus [9]. The basic attachments of the aortic valve leaflets at the aortic annulus comprise muscular and fibrous parts [5]. The right aortic valve leaflet attaches to both the membranous and the interventricular septa, while the non-coronary leaflet attaches to the membranous septum and the fibrous skeleton of the anterior mitral valve leaflet, and the left aortic valve leaflet attaches to the fibrous skeleton of the anterior mitral valve leaflet and partly to the interventricular septum [9]. Connective tissue disorders that involve the fibrous skeleton of the aortic root lead to alteration in normal geometry. Damage begets further damage leading to significant valve distortion and subsequent clinical sequelae [9].
Connective tissue disorder is among the most common non-infective etiology of aortic root pathology. Marfan’s syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome predominantly involve the elastic aortic root [11, 12, 13]. Marfan’s syndrome is an autosomal dominant disorder characterized by mutation in the gene encoding for fibrillin-1. It leads to cystic medial necrosis and involves all connective tissue containing high percentages of elastin. Disease is multi-systemic; however aortic dissection remains an important cause of mortality [14]. The probability of aortic emergencies increases significantly when transverse aortic diameters is more than 45 mm [15].
Patients with vascular type of the Ehlers-Danlos syndrome are prone to aortic dissection rather than aneurysm, while patients with Loeys-Dietz syndrome are liable to have aortic aneurysm and dissection at younger age [11, 16, 17].
Bicuspid aortic valve (BAV) is present in 1–2% of the population; almost 40% also have thoracic aortic dilatation at the time of presentation [18].
While the inheritance of BAV is not clearly defined, gene sequence defects leading to aortopathy is more prevalent in this population [19]. Degenerative changes in the tunica media with reduced elastin increases risk of dissection these patients [20, 21].
Giant cell arteritis and Takayasu arteritis are rarer causes of aneurysmal dilatation/aortic dissection [22, 23]. While temporal artery involvement is the hallmark of giant cell arteritis, at least 0.15% also had aortic dissection in an autopsy series [22]. Takayasu arteritis on the other hand is an inflammatory disorder that leads to large vessel inflammation characterized by fibrosis and narrowing, which may lead to aneurysmal formation and possible rupture [23]. Corticosteroids are used for acute therapy and surgery is performed once active inflammation subsides [24, 25].
Cystic medial necrosis (CMN) is a pathological term that is characterized by the formation of cyst like lesions in the medial layer of the large arteries with accumulation of basophilic substances [26].
The American Association of Thoracic Surgeons present following guidelines regarding surgery for the ascending aorta [27]:
Surgical repair should be performed when aortic diameter (root or ascending aorta) is 55 mm or more.
Surgical repair should be performed when aortic diameter (root or ascending aorta) is 50 mm or more in the presence of certain risk factors such as: root phenotype bicuspid aortic valve, uncontrolled hypertension, history of aortic dissection or sudden death in the family, annual enlargement of 3 mm or more in the size of the aortic aneurysm, or predominantly aortic regurgitation.
Surgical repair should be performed when aortic diameter (root or ascending aorta) is 50 mm or more in patients with low operative risk being performed by experienced aortic surgical team in centers with well-established surgical outcomes
Surgical repair should be performed when aortic diameter (root or ascending aorta) is 45 mm or more in patients undergoing concomitant other cardiac surgery.
Patients with Marfan’s syndrome or Marfanoid habitus should be operated when their aortic root/ascending aorta is larger than 50 mm in maximal transverse diameter [28]. Gott and colleagues [27, 28] reported an improved 30-day survival in a series of 675 patients with Marfan’s syndrome who underwent elective compared to urgent or emergency replacement of the aortic root.
If patients have a family history of aortic dissection, demonstrate an annual increase of 3 mm or have significant aortic regurgitation, then aortic root surgery is warranted when diameters exceed 45 mm [29]. Hormonal changes during pregnancy significantly increase risk of aortic dissection. Hence, women of child-bearing age who are keen to have a family are recommended surgery prior to pregnancy. These guidelines are also applicable to patients with Ehlers-Danlos syndrome and Loeys-Dietz syndrome.
Sinus of Valsalva aneurysms are rare; reported in 0.09% of autopsy series [30]. This condition affects commonly the right coronary sinus to a lesser degree the non-coronary sinus; involvement of all three sinuses is reported but exceedingly uncommon [31]. While idiopathic in majority, endocarditis is a rare cause [32]. Surgery is indicated to prevent rupture [32]. Rupture is often into an adjacent heart chamber with high-out heat failure [33]. Surgery consists of patch closure of the involved sinus. Approach can be from the aorta as well as via the other heart chamber that the fistula opens [30].
Acute aortic dissection is a high-risk aortic catastrophe which occurs in 5–30/1,000,000 patient annually [37]. Almost 1/5th die before reaching the emergency [38]. The initiating factor is often uncontrolled hypertension. Patients may have an intra-mural hematoma prior to developing dissection.
Aortic dissection is classified according to the time after the start of symptoms, being acute if the time frame between the onset of symptoms and presentation is less than 14 days, and chronic if this period is more than 14 days [34]. Anatomical classification is based on the location and extension of the primary tear (Figure 2). Dr. DeBakey and colleagues [35] described a method of classification that differentiates the aortic segments involved into: Type I, when the dissections is involving all the aortic segments, while Type II, when the dissection is confined to the ascending aorta, while Type III, when the dissection process is affecting the descending thoracic aorta. A more functional classification was introduced by the Stanford University; type A if the dissection involves the ascending aorta, type B if it does not [37].
The anatomical classification of aortic dissection according to the location of the primary tear and the extent of the aortic segment involved are illustrated [
The devastating complications that may occur with aortic dissection including organ malperfusion syndromes, acute aortic regurgitation, pericardial tamponade and stroke [38]. Surgery is currently the gold standard for acute care of type A aortic dissection [38].
Bentall and de Bono described their technique of aortic root replacement with a synthetic tube graft and contained prosthetic valve [39]. The coronary ostia were implanted in an end to side fashion without coronary mobilization [39]. Bleeding and pseudo-aneurysms were important complications with their procedure [40]. The present method of coronary mobilization and anastomosis was introduced by Nicholas Kouchoukas [14].
Use of improved graft substitutes and local hemostatic agents have made this procedure safer [41]. Results are good in centers performing these procedures in high volume [40].
The Bentall procedure in younger patients is often performed with a mechanical valve conduit. Appropriate anti-coagulation is important to maintain event-free survival [42]. A recent meta-analysis of 7600 [42] patients who had a mechanical valve conduit reported reoperation rates of Bentall procedure using mechanical valve conduits that the annual linearized rate of occurrence of aortic root re-operation 0.45% (0.039–0.59%). Late mortality was 2.02% (1.77–2.31%) and for hemorrhage was 0.64% (0.47–0.87%) During a mean follow up of 6 years.
However, in older patients, or those who refuse/have contraindications for anti-coagulation, a biologic valve substitute can be used [43]. Gaudino and colleagues demonstrated in a propensity matched cohorts that included patients who underwent aortic root replacement utilizing mechanical valved conduit versus biological valved conduit versus valve sparing procedure that the type of procedure did not influence early or late outcome, however rate of aortic re-operation was 0, 2.4, 7.3% at 5 years for mechanical, biological valved conduits and valve sparing procedure, respectively [43].
Aortic root replacement with cryopreserved homograft tissue is often used for patients with an infected aortic root [44]. The structure of the homograft that includes the muscular part of the left ventricular outflow tract, the anterior mitral leaflet and the aorto-mitral continuity; these provide additional tissue to fill gaps created by aggressive debridement while treating endocarditis [44, 45]. Homograft provide excellent hemodynamics and do not need anti-coagulation. Reports demonstrate improved left ventricular mass regression and ejection fraction after homograft root replacement [46]. However, we would caution their use in young patients. Valve degeneration and subsequent need for re-operation is often inversely proportional to age at implant [44] (Figure 3).
The insertion of cryopreserved aortic homograft is indicated [
We feel that appropriate debridement rather than prosthesis selection determines outcome in patients with aortic root abscess. Jassar et al. reported similar rates of reinfection and reoperation in 134 patients who had aortic root replacement using either cryopreserved homograft, biological or mechanical valved conduits [47].
Stent-less valve conduit (Freestyle™ valve conduit, Medtronic Corporation, Minnesota, USA) are commercially easily available when compared to homograft tissue. Thus, in recent years, they are the prosthesis of choice for aortic root replacement in the elderly or those with an infective etiology [49]. Hemodynamics match those of homograft, especially in patients with a small aortic root [50]. The sinus structure of these valves mirrors the native aortic root; an additional benefit when compared to a stented valve conduit [49]. However, unlike stented bio-prostheses, the mechanism of failure of these valves is often leaflet tears [51]. These can occur suddenly leading to acute aortic regurgitation and left heart failure. LeMaire and colleagues demonstrated in 132 patients who had porcine bioroot replacement that there was no structural valve dysfunction in any case during the 5 year follow up period [52] (Figure 4).
The free style porcine bioprosthesis with re-implantation of the coronary buttons is demonstrated [
Here are the relevant steps that we use for our root replacement procedures. These steps remain the same irrespective of the type of prosthesis (mechanical valved-conduit or bioprosthesis):
We routinely cannulate the right axillary artery for arterial access in cardiopulmonary bypass in all patients with ascending aortic involvement with aneurysmal disease and certainly in all patients with aortic dissection. Our preferred method is direct cannulation of the axillary artery with a straight cannula (usually 18 or 20Fr); otherwise, an 8 mm vascular graft anastomosed in end-to-side manner to the vessel is used.
Upon median sternotomy, pericardium is opened and suspended. Ascending aorta is prepared depending on distal extend of aortic intervention. If feasible, ascending aorta is freed of attachments from the right PA posteriorly and main PA to on the left and taken with an umbilical tape which facilitates further manipulations of the ascending aorta. During this step, it is important to stay close to the aortic wall to avoid injury to the pulmonary artery. For primary aortic root replacement, it is almost always possible to identify and follow such connective tissue plane between the aorta and the pulmonary artery. For a redo operation, it is more difficult and carries some serious risks. We prefer to use cautery dissection rather than scissors or blunt dissection as we feel this technique reduces postoperative bleeding. Small arterial and venous branches are often present between the aorta and pulmonary artery, particularly as one proceeds with dissection more proximally. These are divided between clips. This initial dissection is preferably done prior to full heparinization.
Once the ascending aorta is mostly free of attachments and likely looped with an atraumatic tape, we give IV Heparin and cannulate aorta or the right axillary artery and right atrium for cardiopulmonary bypass. We always use retrograde cardioplegia delivered into the coronary sinus and use either a PA or an LV vent inserted via the right superior pulmonary vein.
Once aorta is cross-clamped and heart is arrested with a combination of antegrade and retrograde cardioplegia, the aorta is transected in mid portion. Clear identification of the ostium of the right coronary artery (RCA) is required, so that the initial cut through the ascending aorta is placed far enough away from the RCA ostium. It is also important to divide ascending aorta in a way that there is at least a couple of centimeters of the aortic wall above the ostium of the left main coronary artery (LMCA).
At this stage we place 4–0 silk stay sutures at the tips of the aortic valve commissures. Aortic valve is then excised, annulus is sized. When a Freestyle valve conduit is used, there is no need to have a cylinder-shaped sizer pass into the LV through the annulus as the prosthetic valve will be fixed in the supra annular position. As such, a larger prosthetic valve can be used. Sizing for a mechanical valve conduit has to be done according to the manufacturer recommendations as most of the mechanical valves are designed for an intra-annular position.
At this stage, additional dissection is carried out between the aortic root and pulmonary artery and RVOT. Unlike for a valve sparing aortic root replacement with root re-implantation, this dissection for a Bentall operation is limited to clearing the space for a safe fashioning of the coronary buttons, particularly, for the LMCA. There is no need to dissect deep between the aortic root and the RVOT to expose the aortic annulus from the outside.
Preparation of the coronary buttons is similar for any aortic root replacement operation. Normally, we start with the left coronary button. Here are the critical points and pitfalls:
Prior to cutting the button out of the corresponding sinus, we recommend marking up the “12 o’clock” point—the top of the button is marked with marker pen or a prolene stitch. This would allow for a precise orientation of the button when re-implanted into a sinus of the valve conduit. Tension or kinking or rotation of the re-implanted button may result in coronary ischemia and create a serious problem at the conclusion of the operation;
Once the top of the button is marked, we start with cutting the left coronary sinus from the top of the commissure between the left and non-coronary cusps down towards the annulus of the left sinus. Most of the time, the actual opening of the LMCA is kept in the middle of the button on all four aspects of it. In larger root aneurysms, there is occasionally too much tissue in the sinus, so attention should be paid to the size of the button 0.5–1.0 cm off of the edge of the ostium of the LMCA is usually enough for a safe button re-implantation;
The initial cut has to keep ~5–7 mm of the sinus tissue in place, so as we come down along the commissure, the tip of the scissors is turned away from the annulus and the cut is curved around the lower edge of the coronary artery ostium;
Next, we start the cut from the top of the commissure between the left and right sinuses. It is critical to fully understand the course of the LMCA to avoid injury to it in case of intramural passing in the aortic wall. Large coronary probe can be placed in the lumen to check the direction of the LMCA. The cut is then curved away from the annulus leaving the same 5–7 mm of the sinus tissue in place and completing a “button” by connecting with incision made from the other direction.
Great care has to be taken here as to not apply any excessive pulling on any portion of the button while making the cuts as this can lead to distortion and asymmetric fashioning of the button making safe re-implantation difficult;
Once the LMCA button is fashioned out, the connective tissue and fat between the lower edge of the button and rim of the sinus remnant and the annulus is divided with cautery to provide just enough mobility for the coronary button to facilitate re-implanting process;
Preparation of the RCA button follows the same general principles as described for the LMCA button—marking the top to maintain orientation, avoiding excessive pulling while fashioning the button, maintaining enough sinus tissue on the button itself as well as on the annulus.
After both buttons are prepared, inflow suture line is created. For a mechanical prosthesis, we use 2–0 pledgeted stitches with the pledgets placed in a suppraannular position. It is important to ensure that the pledgets are lined next to each other without much gap as this will ensure hemostasis. Some use a secondary continuous prolene layer to seal this anastomosis. With Freestyle bioprosthesis, we use simple 2–0 interrupted stitches. A pericardial strip is then gently placed between the loops prior to knotting. The pericardial strip acts as a gusset and also provides additional hemostasis to this layer.
Additional important point has to be made for cases when Freestyle conduit is used. Orientation of the valve is of critical importance prior to drawing inflow sutures through the valve. We recommend rotating the valve 120°clockwise from its natural orientation, so that a non-coronary sinus of the valve would now become a left coronary sinus into which LMCA is re-implanted. Such rotation will make left coronary sinus of the valve a new right sinus into which RCA button will be re-implanted. The right button of the Freestyle remains unused and has to be over sawn with 4–0 or 5–0 pledgeted sutures.
Once an opening in the new left sinus is made with coronary punch, the coronary button is anastomosed using 5–0 prolene. We use a technique of plicating the wall of the coronary button. A second layer is then used to ensure further hemostasis. Re-implantation of the right button is performed in a similar fashion. Once the aortic root is replaced and buttons re-implanted, we use local hemostatic glue to provide further sealing of needle holes.
Then depending upon the extent of aortic dilatation, the ascending aorta is replaced and attached to the proximal neo-root.
Once the patient is off cardiopulmonary bypass, the right axillary artery is carefully repaired between hemostatic clamps. A good Doppler signal is essential after repair.
It is important to ensure absolute hemostasis in the operating room prior to transferring the patient to the intensive care unit.
Sparing the patient’s native aortic valve while replacing the aortic root is an alternative option in selected patients [54]. This naturally avoids need for anti-coagulation [9]. After an initial pre-operative trans-esophageal echocardiogram, the valve leaflets should be examined prior to proceeding with valve-sparing approach. Leaflet quality is fundamental to event-free survival in these patients.
David and Feindel [9] recommend a technique of securing the aortic valve leaflets without the rigid synthetic graft. This technique prevents future annular dilatation. Dr. David et al. report excellent valve competence among 146 Marfan’s syndrome patients with valve-sparing aortic root replacement with their technique [55] (Figure 5).
The aortic re-implantation technique is illustrated (a). As demonstrated, the entire aortic annulus, aortic valve and a rim of aortic wall are all secured inside the synthetic graft, with re-implantation of the coronary buttons to the new graft (b). The distal part of the synthetic graft is anastomosed to the ascending aorta [
All preparatory steps for re-implantation procedure are similar as described above. Below are the critical steps unique for the re-implantation:
Once coronary buttons are prepared as described above, aortic annulus has to be dissected out so that on all sinuses the annulus can be exposed for precise placement of the sub-annular sutures. We use cautery at low settings to perform this dissection. The most difficult part of this step is to separate the root and the annulus from the RVOT. There is always a connective tissue plane between these structures which allows safe dissection down to the annulus;
Sizing of the annulus can be done by many previously described methods. We prefer to follow a simple rule that most of the male with BSA of ~2.0–2.2 m2 should have annulus of 23–25 mm, and so 3–5 mm larger diameter of the vascular graft would be chosen (most commonly, 28 or 30 mm). For a smaller female patient with a BSA of 1.8–2.0 m2 an annular diameter is 21–23 mm and accordingly 26–28 mm grafts are usually appropriate;
We prefer “Valsalva” grafts (Vascutek) which we trim on the inflow side leaving 2–3 mm (a couple of rings) of the grafts for the sub-annular sutures to be drawn through;
We then place sub-annular 2–0 ticron sutures with small pledgetes 2–3 mm below the annulus in the following order: the nadir of the non-coronary sinus; the left-to-non commissure; the nadir of the left coronary sinus; the nadir of the right coronary sinus; the right to-non commissure (avoiding membranous septum); extra sutures placed between the ones mentioned above can added in between the nadirs and the commissural sutures to a total of 6–9 sutures if needed;
Inflow edge of the Valsalva graft then marked to assure precise positioning of the sub annular sutures on the vascular graft;
Sub annular sutures are then drawn through the graft according to the markings;
In re-implantation procedure, instead of silk stay sutures at the tips of the commissures, we use 4–0 prolene with large needles. These stay sutures are brought inside of the graft at this stage, so that the graft is brought over, seated and fixed over the annulus by tying the sub-annular sutures;
Prolene sutures from the tips of the commissures are then drawn through the graft at the junction of the horizontal and vertical parts of the Valsalva graft;
Re-implantation of the aortic root is then started by suturing of the remnant of the coronary sinuses inside of the Valsalva graft. We routinely use double armed 4–0 or 5–0 Prolene and start the suture line just off the bottom of the sinus and proceeding towards the commissure between left and non-coronary sinuses bringing the stich to the top of the commissure on the outside. The other arm of the suture is then brought up the same way to the top of the left and right commissure;
Similar technique is then used to re-implant the right and finally the left coronary sinuses;
All three stay sutures are then tied and cut on top of the commissures followed by “working” sutures brought to the top of the corresponding commissures;
The valve is then checked for AI by filling the root with cold saline;
Coronary buttons are then re-implanted into corresponding sinuses as described above.
Yacoub developed his technique of creating three longitudinal neo-sinuses [56]. These are sutured to the aorta and then coronary buttons are re-implanted. This method does not protect against annular dilatation [9]. In this technique the synthetic graft is fashioned into three longitudinal neo sinuses, then after securing the valve commissures to the neo graft, the margins of the neo sinuses are anastomosed to the rim of the aortic wall. Coronary button re-implantation to the neo sinuses follows, and distal anastomosis of the neo graft to the ascending aorta completed the procedure (Figure 6).
The aortic remodeling technique is described. As shown, the aortic commissures are sewn to the graft, which is fashioned to form neo sinuses. Then the created tongues are sewn to the rim of the aortic wall. Coronary buttons re-implantation follows, then distal anastomosis between the graft and the ascending aorta is performed [
Aortic root operations reflect complex anatomic relations and physiologic interactions between the left ventricle and components of the aortic root—ventriculo-arterial junction (aortic annulus), sinuses of Valsalva, leaflets of the aortic valve, and sino-tubular junction. Whether a surgeon contemplates classic aortic root replacement with mechanical or tissue valve conduits or any of the valve sparing root reconstructions, close familiarity with the structure and function of the aortic root is necessary. Dreaded complications of such complex procedures (bleeding, most importantly) can be avoided by meticulous surgical technique in combination with intimate knowledge of the anatomical details of the aortic root and surrounding structures.
The views expressed are those of the authors and do not necessarily reflect the position or policy of the Department of Veteran Affairs or the United States Government.
Nutraceuticals are promising class of natural products that encompasses the combined terms “nutrition” and pharmaceuticals” which incorporates the characteristics of both nutritional and pharmaceutical and thus exhibit several health benefits. The food or food products having nutraceuticals properties can be used as medicine in addition to nutritional values and have been used to support proper functioning of the body, treat and prevention of diseases, and increase the life expectancy of human beings [1, 2, 3, 4]. Currently nutraceuticals have been explored in several diseases in prevention and cure such cancer, diabetics, cardiovascular, diseases etc.
\nTea (
The black tea is fully fermented and known for its characteristics brown liquor whereas green tea is unfermented and known for its light greenish yellow liquor. The oolong is semi-fermented and liquor characteristic lies in between the black and green tea. All the three types differ in their taste and flavor and accordingly their chemical profiling also varies.
\nTea contains a variety of bioactive compounds such as polyphenols, polysaccharides, vitamins, amino acids etc. having medicinal properties which can be used as food additives in preparation of nutraceuticals [5, 6, 7, 8]. Tea is mainly chemically characterized by their polyphenolic compounds and their polymeriszed products along other bioactive compounds in minor quantities.
\nThe polyphenols which are produced by the plant as secondary metabolites are the major constituents in tea. Other secondary metabolites present in tea are phenolic acids, purine alkaloids, tannins, flavonols and their glycosides. The polyphenols in tea are catechins (C) and their conjugated products viz. epigallocatechingallate (EGCG), epigallocatechins (EGC), epicatechingallate (ECG) and epicatechins (EC) and present in higher quantities in green tea. The other two class of polyphenols found in black tea are theaflavins (TFs) and thearubigins (TRs) which are present in significant quantities in black tea and less quantity in oolong tea. The catechin polyphenols in tea are health-promising due to their antioxidant properties and are very useful in preparation of nutraceuticals from tea [9, 10, 11, 12, 13, 14].
\nIn addition, tea contains other beneficiary substances to our health such as fluoride, caffeine, minerals, trace elements e.g. manganese, chromium etc. which also added nutraceutical value of tea and its food additive which also add nutraceutical value of tea or its food additives [15]. Looking to the therapeutic properties of these phytochemicals in tea, different food products have been prepared with tea or its extract which are rich in these active ingredients. These products include ready to drink beverages, instant tea, confections, cereal bars, pet foods, candy etc. So, there is a huge possibility of using bioactive constituents in tea as food additive which provide medical or health benefit in prevention and treatment of disease and thus tea can be potentially used for the development of nutraceuticals.
\nIn this chapter, various bioactive compounds in tea (green, black, oolong and white teas) and their properties which can be employed as nutraceuticals in the form of food or part of food products has been discussed. Further, we have addressed the role of these tea nutraceuticals and their application in prevention and treatment of various diseases.
\nThere are a variety of chemicals in tea which are therapeutically important and they also vary in different types of commercially available teas viz. green, black and oolong tea. The chemical characteristics of tea are also varying with variation of plant species, geographic locations, climatic condition, horticultural practices as well as plucking parameters of the tea leaves [16, 17]. Polyphenols comprises of a large group of phytochemicals, the major polyphenolic constituents in tea which account for maximum 30% total dry weight of tea leaves are the flavanols, also known as catechins. Of these polyphenolic catechins, eight catechins are appeared in significant quantities which include (+)-catechin, (-)- epicatechin, (-)-gallocatechin, (-)-epigallocatechin, (-)-catechin gallate, (-)-epicatechin gallate, (-)-gallocatechin gallate, (-)-epigallocatechin gallate.
\nTea beverage is chemically characterized mainly by polyphenolic constituents (mostly flavonoids) and their polymerized compounds. Four polyphenolic catechins which are in large quantities in green tea are (–)–epigallocatechin- 3-gallate (EGCG), (–)–epigallocatechin (EGC), (–)–epicatechin-3- gallate (ECG), and (–)–epicatechin (EC) (Table 1). These catechins are highest in green tea (30-40% in dry weight) and least in black tea (10% in dry weight) in which catechins undergo condensation and polymerization into other phenolic compounds theaflavins and thearubigins during enzymatic oxidation of catechins during fermentation process of black tea manufacturing [18, 19]. The oolong tea has substantial amount of catechins with other oligomeric polyphenols [20].
\nChemical structures of major polyphenols (flavonoids: flavanols and flavonols) in Green tea and Black tea.
Apart from polyphenols, there are a number of phytochemicals which are significantly important in medicinal use. These phytochemicals are oxyaromatic acids (gallic, caffeic, quinine, chlorogenic and n-coumaric acids, flavonols (Quercetin, kaempferol, myricetin), pigments (carotenoids, chlorophyll), alkaloids (caffeine, theophylline, theobromine), amino acids, lipids, polysaccharides, vitamins, lignans and saponins which also attribute to the widely explored medicinal value of tea [21, 22, 23].
\nThe major polyphenolic compounds in different types of tea which differ due to their manufacturing processes are highlighted in Table 2. The white tea is least processed of all the tea types and thus it intakes maximum polyphenols whereas the black tea is fully fermented through enzyme mediated oxidation of polyphenols into oligomeric and polymeric flavanols (theaflavins, thearubigins and other oligomers) with characteristics flavor and color. In black tea processing, tea leaves (standard plucking two and a bud) are crushed to undergo enzymatic oxidation (polyphenol oxidase) and subsequent condensation of tea catechins in to the formation of theaflavins (TFs) (oligomeric) and thearubigins (TRs) (polymeric) products. This fermentation process is being limited in case of oolong tea. In green tea this enzymatic oxidation is prevented by steaming (or pan-frying) of fresh tea leaves. Therefore, the green tea infusion contains major quantities of polyphenol catechins (30-40% dry weight of four major catechins viz. (–)-Epigallocatechin-3-gallate (EGCG), (–)-epigallocatechin (EGC), (–)-epicatechin-3-gallate (ECG), and (–)-epicatechin (EC)). Since all major polyphenols are oxidized in black tea, it contains less amount of catechins (3-10%) along with theaflavins (2-6%), thearubigins (>20%) and gallic acids in significant quantities. The oolong contains green tea catechins and less amount of black tea theaflavins and thearubigins due to its partial fermentation process.
\nType of tea | \nProcessing technique | \nPhysio-chemical changes | \nMajor polyphenols | \n
---|---|---|---|
Green | \nWithering, steaming (Japan) or roasting (China), rolling and drying | \nDeactivation of enzymes to prevent fermentation (oxidation of polyphenol) | \nCatechins (Flavan-3-ols) | \n
Black (red tea) | \nWithering, crushing, rolling, drying | \nFermented (in presence of enzymes (polyphenol oxidase and peroxidase enzymes) | \nCatechins, theaflavins, thearubigins | \n
Oolong | \nWithering, rolling, drying | \nPartially fermented (partial oxidation) | \nCatechins, theaflavins, procyanidins | \n
White | \nWithering, drying | \nUnfermented | \nCatechins | \n
Major polyphenols and processing conditions of different varieties of tea.
In water extract, all types of tea also contain caffeine in quantity of 2-5%.
\nThe therapeutic properties of tea extract are associated with the polyphenolic contents which have the highest antioxidant capacity amongst other bio-active compounds. The green tea extract has higher antioxidant capacity than that of black tea or oolong tea due the higher quantities of catechin polyphenols viz. EGCG, EGC, ECG, EC [24]. The EGCG has the highest anti-oxidant activity followed by ECG and EC whereas EGC has the lowest activity [25]. The EGCG can inhibit the production of hydrogen peroxide and superoxide radicals by tumor promoter-activated neutrophils in our body. Among the three major types of tea (green, black, oolong), green tea has the highest antioxidant activity and black tea has the lowest one. The antioxidant activity of green tea and its polyphenols have been studied in a number of
Recent researches have gained attention in therapeutic use of tea polyphenols of green and black tea in diseases associated to metabolic syndromes. Green tea catechins have been explored to antioxidant, anticarcinogenic, anti-inflammatory, probiotic, anti-inflammatory, thermogenic, and antimicrobial activities. These have been found to inhibit carcinogenesis of the skin, lung, esophagus, stomach, liver, small intestine, colon, bladder, prostate, and mammary gland in animal studies [26]. Black and green tea can protect oxidative damage of red blood cells [27].
\nLooking in to the various health benefits of tea phytochemicals, tea extracts in liquid or powder form can be effectively used in food products such as sweets, biscuits, bread, cake, candies, ready-to-drink beverages as well as other polyphenol rich food supplements. The tea nutraceuticals are also available in various form of tablets, capsules and health drinks. In addition, tea also contains other nutritional substances such as dietary fiber and proteins after polyphenols extraction in tea for use in nutraceuticals which also give health benefits [28]. Consumption of tea with lemon juice (ascorbic acid) has manifold benefits in making more accessible of tea antioxidants (catechins) to get absorbed as well as enhance the iron absorption in our body [15]. Further, compounds in tea can inhibit iron absorption from foods; drinking green tea with lemon reduces that effect. The combination of honey with green tea has been used since very past as they are very effective in healing wounds. The health-promoting activities of tea also vary cultivar to cultivar and thus it is important to identify the cultivars having specific bioactivity so as to use the nutraceutical properties properly. The phytochemicals in tea and their nutraceutical properties are depicted in Figure 1.
\nRole and mechanism of nutraceutical properties of tea phytochemicals.
Tea is beneficial in protection and prevention of numerous critical diseases such as different cancers, diabetes, neurodegenerative and cardiovascular diseases [29, 30, 31]. The polyphenols, the major phytochemicals present in tea are known for their antioxidant properties due to their abilities to scavenge free radical species such as hydroxyl radical (OH), hydrogen peroxide (H2O2) and superoxide anion (O2.−) and thus their consumption confer them as potential cancer chemopreventive agents as well as other free radical induced diseases. The polyphenol extract of tea has been effectively used in cancer prevention, protection cardiovascular diseases, reduce weight-loss, anti-allergic, prebiotics, osteoarthritis protection etc. [32, 33]. Green tea extract comprises of nearly 40% of polyphenols of which nearly 25% accounts for different catechins and their gallates of which EGCG is the highest in quantity (about 11%), the most studied polyphenols in therapeutic properties. Black tea polyphenols theaflavins, theaflavin gallates (which are dimers of two different catechins and their gallates) and thearubigins with 2-6% in quantity in addition to 3-10% of catechins gain attention in different diseases [34].
\nHerein, we wish to discuss the health benefits of tea in common and major diseases such as diabetes, cardiovascular diseases, obesity, cancers, as well as others minor diseases related to microbial and inflammatory types. The role of major phtochemicals of tea in different diseases is outlined in Table 3.
\nDiabetes mellitus, a highly alarming disease worldwide is associated with high levels of blood glucose other than normal which is associated with insufficient insulin production or its ineffectiveness.
\nPolyphenols in green and black tea are very effective in reducing hyperglycemia and insulin resistance which can manage the blood glucose in diabetes [31, 35, 36].
\nThus, tea polyphenols present potential nutraceuticals for various facets of type 2 diabetes mellitus. In type 2 diabetes, insulin tolerance is developed following major metabolic disorder which led to numerous health complications reducing the quality of life and increasing the mortality rate [37]. It has become evident from various
It has been reported that polyphenols have the hypoglycemic effects which are associated in reducing intestinal absorption of dietary carbohydrates affecting glucose metabolism, improvement of β-cell function and insulin action, inducing insulin secretion, and anti-inflammatory and anti-oxidative activity [39].
\nThe cardiovascular diseases such as hypertension (high blood pressure), coronary heart diseases (heart attack), cerebrovascular disease (stroke), heart failure, peripheral vascular diseases, etc. have been increasing day by day. The major causes of these are foods habits, chemicals used in food and food products, chemicals used in cultivation as well as lack of awareness.
\nGreen tea consumption has been found to be effective in reduction of cardiovascular related disorders through decreased serum cholesterol and triglyceride. It has been reported in a study carried out in Japan that regular green tea consumption (≥500 mL) reduced the mortality rate in women in cardio vascular diseases by 31% as compared to those who consume non-regularly [40].
\nThe green consumption has the effect of reducing the risk of coronary heart diseases by lowering the hyperlipidemia and total body cholesterol in body [41]. Moreover, EGCG the major catechin in green tea has been shown its usefulness in cardioprotective effects (inhibiting the formation of cardiac hypertrophy), antithrombotic and antiplatelet activities which are associated with cardiovascular diseases [42]. The theaflavin and thearubigins in black tea functional drinks are valuable against lipid and glucose related abnormalities especially high cholesterol and LDL levels [31].
\nObesity has been considered as a serious concern globally effecting large number of peoples. It is associated with accumulation of excess body fats which stimulate various disorders in body such as hypertension, osteoarthritis, hyperlipidemia, heart attack, etc. [43] It is identified as a major factor in many metabolic syndrome such as stroke, heart failure, hypertension, diabetics, arthritis, etc.. The oolong tea food products also were also found to be very effective in decrease of in weight of obese people [44]. The green tea catechin, EGCG has been found to be beneficial on obesity [45]. Catechins in tea helps in weight management and consumption of green tea catechins results significant reduction in body weight in human [46].
\nTea phytochemicals are useful in treatment and prevention of various types oral diseases which include tooth decay and oral cancers [47, 48], dental plaque and dental caries [49]. The tea extract and fluoride in tea can prevent the carcinogenic activity of oral bacteria such as
Tea nutraceutical acts as powerful antioxidants are very much promising in prevention of cancers. Experimental studies have demonstrated the use of tea bioactive compounds in prevention of cancers in different organs [51]. The tea catechins has been found to act as anticarcinogenic and chemopreventive agents. Several animal model studies in mice showed the inhibiting of chemical induced 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis, tumor cell proliferation, progression of adenoma to carcinoma, as well as lung carcinogenesis. [52]. It has been conferred from several experimental evidences that tea can be effectively used in inhibition of carcinogenesis in different parts of our body such as skin, lung, stomach, esophagus, liver, small intestine, pancreas, colon, bladder, etc. [53]. In these experimental studies it was found that polyphenols in green tea acted on cell apoptosis, cell proliferation, cell cycle in tumour growth and migration. All these activities resulted in reduced the risk of certain types cancers such as skin, colorectal, prostate, breast etc. through their activity in cell apoptosis, cell proliferation, cell cycle in tumour growth and cell migration. Among four major catechins in green tea, EGCG has been extensively studied and found to be most effective polyphenols [54]. Theaflavins in black tea inhibit the DNA damage which is a major cause of induction of cancer [55] The anti-carcinogenic activity of tea polyphenols is associated with their capacity to bind with carcinogens and thereby enabled the metabolism. Cancer preventive activity of black tea is known from the report of induction of apoptosis in human leukemia cells by black tea and its polyphenols [56]. Black tea is also effective in protecting immunocytes from tumor-induced apoptosis [57].
\nConsumption of tea has other several promising-health benefits such as it decrease the risk of hypertension [58], lowers the risk of osteoporosis, protects against the risk of hip fractures [59, 60], improves the metabolic activity of the bacteria in intestinal tract [61].
\nThe bioactive compounds in oolong tea such as polyphenol, caffeine have the antistress and antioxidant activities which can prevent the diseases related to stress [62]. The green tea catechin, EGCG is useful in inhibition of HIV infection and HIV-1 replication and multi-drug resistant
Some other beneficial effects of the constituents are antiaging, stress control, ant-bacterial, anti-viral, and useful in Parkinson’s disease, Alzheimer’s disease etc. Recently, Tencomnao et al. [67] discussed the results of some
Phytochemicals of tea | \nHealth benefits | \n
---|---|
Polyphenol extract of green tea | \nCancer prevention, protection cardiovascular diseases, reduce weight-loss, anti-allergic, prebiotics, osteoarthritis protection etc. | \n
Epigallocatechin-3-Gallate (EGCG), Epigallocatechin (EGC), epicatechingallate (ECG) | \nAnticancer, cardioprotection, Neuroprotection, Obesity management, osteoprotection, Anti-inflammation, Diabetes control and renal protection, Antimicrobial and skin care etc. | \n
Theaflavins, Thearubigins, bisflavonols | \nAntioxidative, antithrombogenic, and anti-inflammatory, anti-carcinogenic, anti-mutagenic, neuroprotective etc. | \n
Role of major phytochemicals of tea in different diseases.
Green tea supplements | \nObserved effects | \n\n | \n
---|---|---|
Polyphenol extract | \nIncrease in hydroxyproline content and catalase activity, Decrease in protein carbonyl content, Inhibit protein oxidation induced by UV radiations. | \nMice | \n
Aqueous extracts | \nIncrease the level of collagen and elastin fibers. Reduced expression of MMP-3 enzymes. | \nMice | \n
Green tea extract | \nReduce muscle atrophy and mediate insulin resistance, Reduce fat accumulation and lipid droplets. | \nMice, | \n
Epigallocatechin gallate (EGCG) | \nReduce the number of cells affected by sunburn, Maintain equilibrium during redox reaction. | \n\n |
EGCG | \nExtend lifespan. | \nDrosophila, | \n
Cholinergic acid | \nDelay age-related decline in body movements | \n\n | \n
Theanine | \nStress resistance and lifespan extension. | \nC. elegans | \n
Crude green tea extract | \nReduction in total body iron. | \nFruit flies | \n
Effect of green tea on photoaging, stress resistance, neuroprotection and associated health complications: in vivo studies [67].
Green tea supplements | \nObserved effects | \n\n | \n
---|---|---|
Polyphenol extract | \nConjugate metabolites in plasma, blister fluid, and skin biopsy samples | \nConsume capsules of green tea polyphenols | \n
Green tea extract | \nReduction in the level of cells with sunburn; Lesser DNA damage when compared to vehicle control; Reduced the prevalence of Alzheimer’s disease and cognitive impairment; Free radical scavenging and anti-wrinkle effects | \nTopical application | \n
EGCG, EC, and EGC | \nDecreased sunburn cells (Lesser activity when compared to the crude extracts). | \nTopical application | \n
Polyphenol extract | \nImprovement in facial skin and in controlling erythema | \nOral supplements of green tea polyphenols | \n
Effect of green tea on photoaging, stress resistance, neuroprotection and associated health complications: Clinical trials [67].
This chapter discusses the nutraceutical properties of bioactive compounds in tea in particular polyphenols and their role in health benefits. The catechins in tea viz. EGCG, EGC, ECG and EC have therapeutic properties such as antioxidant, anti-diabetic, anti-microbial, anti-inflammatory as well as anti-cancer properties. The black tea polyphenols the flavins and thearubigins also show many profound therapeutic values. In addition, oolong tea and white tea are also pharmacologically important. Therefore, consumption of tea in its various form viz. green tea, black tea, oolong tea and other food products with tea as active ingredient have been increased now a days. There are many more food products with tea and or its extracted components as additive have been developed which includes instant tea beverage, confections, cereal bars, pet foods etc. Considering the growing interest in nutraceuticals due to their several health values, the aim of the present chapter is to outline the nutraceutical potential of phytochemicals of tea with their known therapeutic properties. Due to their ready bioavailability, the possibilities of using nutraceuticals from tea as natural healers in treatment and prevention of diseases have been explored.
\nAuthor specially thanks to the Tocklai Tea Research Institute, India for giving support during the tenure of working on tea research as scientist.
\n"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
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\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
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