\r\n\tTo sum up, there are numerous engineering applications of diamond which are yet to be realized and this book will address some of the mentioned and hopefully open some new topics.
\r\n\t
Total ankle replacement (TAR) was introduced for end-stage arthritis of the ankle joint in the 1970s. Initial poor clinical results due to imperfect prosthesis design and our incomplete knowledge of the biomechanics of the foot and ankle limited the using of TAR. Despite high numbers of failures in early generations of ankle prostheses, there has been a continued and increasing interest in TAR for end-stage arthritis. Nowadays, scientists are working on fourth-generation ankle prostheses, which are characterized by three-part, mobile-bearing, uncemented design. The STARTM ankle prosthesis was one of these fourth-generation ankle prostheses, which was approved for use by the United States Food and Drug Administration (FDA) in May 2009. The clinical outcomes of TAR have been increasing in terms of progress. Newer studies suggested that implant survival rates were 70% to 95% during follow-up periods that ranged from 2 to 12 years. TAR is increasingly used as an alternative to arthrodesis.
The ankle joint is subjected to more weight-bearing force per square centimeter and is more commonly injured than any other joint in the body. Approximately 6% to 13% of all cases of osteoarthritis (OA) involve the ankle joint. While the incidence of severe ankle arthritis is clearly less than that of the hip or knee, OA of the ankle is a main cause of disability, which impairs functional mobility and leads to poor quality of life. Unlike the hip and knee joints, in which the primary causes of degeneration are primary OA and inflammatory diseases, 70–80% of ankle arthritis is post-traumatic and the remaining cases are related to primary OA and rheumatoid arthritis [1, 2, 3].
The treatment options for severe ankle arthritis have changed during the past 10 to 15 years. Currently, treatment options include ankle arthrodesis and TAR. There remains considerable controversy surrounding the benefits of each procedure and treatment option, especially concerning the idea that patients might benefit from one approach more than the other. TAR has some disadvantages such as expensive cost, implant loosening, ankle instability, higher infection rate, and higher re-operation rate [6–9]. TAR remains a less satisfactory solution when compared to other joint replacements; however, TAR offers greater range of motion in the ankle with improved gait kinematics, reduced stress, and potentially causes less arthritis in adjacent joints [3]. In addition, with regards to cost-effectiveness analysis, TAR has better quality-adjusted life years when compared to arthrodesis, albeit at a higher cost [10].
In this chart, we will introduce the decision-making process of whether to use TAR or arthrodesis, as well as discuss the history of TAR, the characteristics of different prosthesis designs, their clinical outcome, and the complications and revisions associated with TAR.
Lord and Marotte introduced an inverted hip prosthesis as a disappointing solution for ankle replacement in 1970 [4]. The original first-generation TAP was non-anatomical, cemented, and restrictive. It is not surprising then that the original first-generation TAP prostheses are associated with severe osteolysis, component loosening, impingement, infection, and soft-tissue breakdown; this has led many surgeons to discredit this procedure. For these reasons, there has been a continuous effort to develop a safe, stable, and long-lasting ankle prosthesis that could replicate the complex anatomy of the ankle joint and better mimic ankle biomechanics.
Implant design played a large role in the effect of loading direction on the magnitude and direction of the joint’s motion. Bone–implant displacements occurred along the directions expected on the basis of the implant interface geometries. Various ankle designs are available, including two-component and three-component systems [5]. After unacceptably high failure rates had been published for the first generation of implants [1–5], the second generation of implants achieved marked improvements in clinical outcomes [6–8]. Second- and third-generation prostheses followed these first implants, and interest in this procedure has resurged in the past decade. These new designs include changes in the geometry and design of the components, as well as the use or non-use of polymethylmethacrylate bone cement, which is termed a two- or three-component design. The third-generation prosthesis is characterized by the non-use of cement, accurate anatomy, and better ROM of the ankle joint. Mobile-bearing implants are designed without constraint to reduce meniscal wear and to increase the longevity of the implant, which features mobile PE inlays. The stability of the bone–implant interface has been explored in an unconstrained, three-piece mobile-bearing implant using the concepts of implant migration and inducible displacement. Fixed-bearing designs, in contrast, are designed to increase stability, reduce micromotion at the bone–implant interface, and decrease bearing dislocation. In addition, the surgical instrumentation and technique are improved and redesigned for the new prosthesis.
The third-generation of ankle prostheses includes the HINTEGRA ankle (New deal, Lyon, France/Integra, Plainsboro, NJ, USA), the INBONE TAR implant (Wright Medical Technology, Arlington, TN, USA), the Agility prosthesis (DePuy Orthopaedic, Warsaw, IN, USA), the STAR prosthesis (Scandinavian TAR), the Mobility prosthesis (DePuy, Leeds, United Kingdom), and the Salto Talaris (Tornier, Edina, MN, USA).
The HINTEGRA prosthesis is a three-component, mobile-bearing ankle replacement with cobalt–chromium tibial and talar components [6]. The polyethylene mobile-bearing element provides axial rotation, physiological flexion, and extension mobility, and it also provides inversion and eversion stability [7, 8]. The HINTEGRA, which is a flat, anatomically shaped component, fully contacts the resected area with fixation of its tibial component. All inserted components have locking pegs on the talar component. The tibial component consists of a flat tray with raised spikes for bone fixation. The anterior side has a flange with holes for screw fixation. The talar component has medial and lateral walls and two fixation pegs; two screws may be used for added fixation, if appropriate. The ingrowth surface is plasma-sprayed titanium with a hydroxyapatite coat [9, 10]. Therefore, the HINTEGRA ankle prosthesis may be used for the treatment of major coronal plane deformities and as a salvage of failed ankle replacements.
Amongst the third-generation ankle implants approved by the US FDA, the INBONE TAR implant employs a fixed-bearing design with a modular stem system for both the tibial and the talar components. The INBONE system features a technique that offers potential advantages in improved stem fixation and a unique intramedullary alignment system. It has a broader polyethylene component that conforms to the saddle ankle geometry, and it also provides a large surface area that spreads out stress gradients, leading to possible decreased wear [11]. A. Datir found that only the lateral talar component angle and the mean difference between the pre- and postoperative tibial slope had significant correlations with postsurgical outcomes in INBONE ankle replacement [11].
The Agility TAR System, which is almost exclusively without polymethylmethacrylate cement fixation, was the most commonly used implant in the United States from 1998 to 2007. The design process started in 1978, with prototype completion and cadaver implantation occurring in 1981 [12, 13]. It was first implanted in a patient in 1985 and subsequently marketed in 1992 as the “DePuy Alvine Total Ankle Prosthesis”. From 1985 to 2007, the implant went through a total of four generations and seven phases of implant improvement [13, 14]. The US FDA has cleared it for use only with polymethylmethacrylate cement fixation [15]. The Agility prosthesis is a semi-constrained ankle replacement with a cobalt–chromium talar component, a titanium tibial component, and a fixed polyethylene bearing [16]. It is characterized by a tibial component, which provides a talar component with a larger surface area. The talar component of the Agility system was prone to shift forward and backward along the talar groove during plantar flexion–dorsiflexion loading, and it would also rock about its long axis in inversion–eversion loading. The ingrowth surface consists of cobalt–chromium sintered beads. Fixation on the tibial side is aided by syndesmotic arthrodesis. Fixation on the talar side is achieved with the use of a keel under a flat-cut component.
The STARTM ankle was first approved by the US FDA in 1998 [17]. It was a three-part, mobile-bearing, uncemented ankle replacement. The STAR prosthesis featured a cementless design with a plasma-sprayed titanium coat [18]. Fixation on the tibia was achieved with use of two barrels on the flat tibial component. The talar component was fixed with the use of two sidewalls and a fin on the inferior surface. The tibial component of the STAR was most susceptible to normal motion on the bone surface, especially in plantar flexion–dorsiflexion and inversion–eversion loading. On average, of the three loading directions, the internal–external rotation resulted in the smallest relative motions of both of the STAR components since the device allowed for unconstrained rotation about this axis [19].
The Mobility prosthesis is a mobile-bearing ankle replacement with cobalt–chromium components on the tibial and talar sides, and it also features a sintered bead ingrowth surface [20]. The tibial component has a stem placed into the tibia with an anterior bone window. The talar component has two fins on the inferior surface; no sidewalls are present on the talar component. The talar cut has three surfaces. The prosthesis has not undergone design changes during the course of the study.
The Salto Talaris TAP, with design and instrumentation based on the Salto mobile-bearing TAP, was approved for use by the US FDA in 2006. Although it is a fixed-bearing device, the instrumentation and component trialing incorporate a rotationally mobile tibial trial component that allows for self-alignment on the resected surface of the distal aspect of the tibia, which is determined by the talar component. The final implant has a polyethylene insert that is rigidly fixed to the tibial component and does not allow for rotational or translational motion between the two surfaces.
Normal ankle kinematics attenuates ground reaction impact forces and impact loading on the subtalar joint. The importance of achieving normal ankle kinematics during stance is very important for both function of the ankle and long survivorship of the prosthesis. During a normal gait cycle, the talus has a continuously changing axis of rotation against the tibia as well as a gliding motion against the calcaneus, respectively. The talus and mortise widen slightly anatomically from posterior to anterior. Following talus plantar flexion, the narrowest portion of the talus sits in the ankle mortise and allows for rotational movement between the talus and mortise. When the talus is maximally dorsiflexed, the wider portion of the talar articular surface locks into the ankle mortise, allowing for little or no rotation between the talus and the mortise [21, 22].
Compared to a normal ankle, ankle OA shows a significant deficiency in triplanar ankle movement, the second active maximal vertical and maximal medial ground reaction force, sagittal and transverse ankle joint moments, and ankle joint power [2]. However, J.F. Baumhauer reported that ankle arthrodesis results in a normal gait postoperatively, especially when there is a normal subtalar joint and talonavicular joint [23].
S. Singer reported that TAR with first-generation TAP resulted in increasingly normal gait mechanics during sagittal joint motion, which was maintained, and it also resulted in more normal ankle kinematics when compared with those following arthrodesis [24]. The gait patterns of TAR with the third-ankle prosthesis more closely resembled normal gait during sagittal plane motion and dorsiflexion, and it also resulted in a normal range of tibial tilt when compared with the gait patterns of patients following arthrodesis [24]. Peak plantar flexor moment increased in arthrodesis patients and decreased in TAR patients. TAR appears to regain more natural ankle joint function. R.M. Queen compared the kinetics of TAR with that of the INBONETM or Salto Talaris, as well as that of the normal contralateral ankle in bilateral patients; the results showed that walking speed, step time, step and stride length, and propulsion ground reaction forces improved following TAR. However, peak dorsiflexion did not change. At the same time, the dorsiflexion angle during heel strike was increased on the nonsurgical side [25].
A. Rosello Anon et al. reported that kinetic gait parameters were similar to those of a healthy ankle following TAR with HINTEGRA [26]. M.E. Hahn reported that both arthrodesis and TAR patients were similar in terms of demographics and anthropometrics. Neither group increased their average daily step count [27]. Gait patterns in both treatment groups were not completely normalized [24]; however, both treatment groups did not exhibit equivalent to normal plantar flexion motion, ankle moments, and power when compared with the normal group. Further investigation is needed to determine why patients who have undergone TAR do not use the plantar flexion motion in the terminal-stance phase, as well as to explain the limited increase in power generation at toe-off after replacement [24].
In addition, walking speed, step, and stride length improves from the preoperative phase to each postoperative time point. Peak dorsiflexion did not changed over time or between sides; however, the dorsiflexion angle during heel strike was increased on the nonsurgical side. Peak plantar flexion moment, stance, step time, weight acceptance, and propulsion ground reaction forces improved from the preoperative period to 1 year postsurgery on the surgical side. These results indicated that fixed-bearing TAR was effective at improving gait mechanics in patients with painful end-stage ankle arthritis. In addition, TAR resulted in the maintenance of ankle dorsiflexion during the stance phase; however, a decrease in dorsiflexion angle was present during heel strike on the operative side when compared with the nonoperative side up to 2 years following TAR. Finally, following TAR, the asymmetry in temporal gait variables and peak plantar flexion moment were improved, although differences did remain between the operative and nonoperative limbs for stance, step, and swing time, as well as for the peak plantar flexion moment 2 years following TAR. This remaining gait asymmetry is of potential concern because of the possibility that the patient might overload the contralateral limb and engage compensatory walking mechanics that could lead to secondary injuries following TAR [25].
If adequate conservative measures for the treatment of end-stage ankle osteoarthritis have failed, surgery may be taken into consideration. M.R. McGuire reported that TAR is indicated in rheumatoid patients with severe ankle involvement who have not responded to medical management. TAR is especially suitable for those patients who will place minimal stress on the ankle, those for whom no destruction of the hip or knee joint is found, and for those who are 65 years of age or older. The elderly may not tolerate the prolonged immobilization or repeated operations that arthrodesis may require. TAR should not be used in young patients with post-traumatic arthritis [28]. J.R. Ramaskandhan found that early outcomes following TAR for patients with post-traumatic OA are comparable with those for patients with OA and rheumatoid arthritis [29]. More importantly, patients whose lifestyle or employment requires them to walk down ramps may have an advantage with TAR when compared with an arthrodesis. In addition, I. Hetsroni reported that TAR has better quality-adjusted life years when compared to arthrodesis, albeit at a higher cost [10].
TAR improves clinical and functional outcomes independent of preoperative tibiotalar alignment when postoperative alignment is restored to neutral at the time of replacement. Therefore, one of the keys to success may be to achieve coronal plane balance by performing additional osseous and soft- tissue procedures in patients with coronal plane deformity [30]. Preoperative talar varus deformity increases the technical difficulty of TAR and is associated with an increased failure rate. Deformity of >20° has been reported to be a contraindication to replacement. T. Trajkovski determined whether clinical outcomes of TAR in patients with ankle arthritis and a preoperative talar varus deformity of 10° were comparable with those of patients with a varus deformity of <10°. Satisfactory results can be achieved in patients with varus malalignment of 10°, which should not be considered a contraindication to TAR [31].
With the population ageing, the absolute number of patients affected by ankle OA is likely to increase, which means that there are more and more potential candidates for TAR. For this reason, there is a trend of increasing indications; as such, clinical guidelines regarding implant migration must be established to ensure successful outcomes [3]. On the other hand, some patients might be younger and have higher physical demands, placing the damaged joint under increased stress [32]. Based on this, young age and high physical demand are currently considered contraindications for TAR.
Taking into account numerous individual criteria, the most appropriate indication substantially influences the outcome of patients with end-stage ankle arthritis who are treated by ankle TAR.
We present a typical case who underwent TAR. She was a 59-years-old woman and had a severe pain on her left ankle. She failed to respond to a trial of conservative treatment for ≥6 months.
The preoperative X ray images showed a severe osteoarthritis in the left ankle.
The picture showed incision and the osteotomy.
The pictures showed that the ankle joint is in a good alignment with the template.
The pictures showed the X rays image of ankle joint after TAR 2 years postoperatively.
Modern TAR systems have either a fixed-bearing or a mobile-bearing design. In the United States, fixed-bearing, two-component designs are more commonly used. S. Noelle reported that STAR prostheses achieved a high satisfaction rate following TAR, and exhibited clear pain relief in patients between March 2005 and May 2010 [33]. J.R. Jastifer reported that the overall implant survival of STAR prosthesis was 94.4% at a minimum of 10 years of follow-up. A total of 39% of patients required additional surgical procedures, most of which were performed more than 9 years postoperatively, and one patient required a revision of the prosthesis. Preoperative VAS pain scale scores, Mean Buechel–Pappas Scale scores, and mean AOFAS Ankle–Hindfoot Scale scores improved from 8.1 to 2.1, from 32.8 to 82.1, and from 32.8 to 78.1 at the latest follow-up, respectively. All patients reported their outcomes as good or excellent. In the current cohort of STAR ankle patients, implant survival, patient satisfaction, pain relief, and function ratings were high. However, the rate of additional procedures was also high, which highlights the need for patient follow-up and additional long-term outcome studies on TAR [17].
Early clinical results indicate that the Salto Talaris fixed-bearing TAR system can provide significant improvements in terms of pain, quality of life, and standard functional measures in patients with end-stage ankle arthritis [34]. Implant survival at a mean follow-up time of 2.8 years was 96% when metallic component revision, removal, or impending failure was used as the endpoint. For the Salto Talaris total ankle implant, a high incidence of bony overgrowth occurs at the margins of the tibial tray. The frequency and amount of overgrowth were directly related to the amount of cortical coverage at the bone–implant interface [35]. Patients who underwent TAR with the INBONETM or Salto Talaris prosthesis demonstrated that they were able to walk faster, and they also exhibited an improvement in gait symmetry. However, this improvement did not appear to return the patient to a symmetric walking pattern by 2 years post-TAR [25].
The Agility prosthesis typically exhibited greater relative motion than did the STAR, with significant differences observed for both the tibial component in inversion–eversion rotation and for the talar component in internal–external rotation. The magnitudes of the relative motions were affected by the loading direction and compression. The motion magnitudes were quite large, with values exceeding 1, 000 mm for the Agility talar component in plantar flexion–dorsiflexion and in inversion–eversion. Large motions at the bone–implant interface, resulting from weak initial fixation, may inhibit implant osseointegration early in the healing process, and it may also contribute to the overall likelihood of implant failure resulting from aseptic loosening [19].
The overall survival rates of the HINTEGRA implant were 94% and 84% after 5 and 10 years, respectively. The mid-term survivorship of the HINTEGRA implant was comparable with that of other third-generation TARs [36]. The mid-term to long-term survivorship of a TAR in which a HINTEGRA implant was used is promising, and it is in agreement with the survivorship findings for other third-generation total ankle implants. There were no polyethylene failures and amputations. The generation category of the prosthesis, the cause of ankle OA, and the age of the patient were identified as independent risk factors for prosthesis failure.
There is a concern that placing a TAP in the setting of a fused hindfoot will create abnormal stresses on the ankle joint and will thus lead to increased early wear or degeneration of the implant. Ipsilateral hindfoot arthrodesis in combination with TAR may diminish functional outcome and prosthesis survivorship when compared to isolated TAR. J.S. Lewis reported that TAR with the STAR performed with ipsilateral hindfoot arthrodesis resulted in significant improvements in pain and functional outcomes, which was in contrast to prior studies; however, overall outcomes were inferior to those observed for isolated TAR [37]. The authors of this study have speculated that the mobile-bearing design may play an important role in the transfer of rotational movement from the tibia into calcaneal inversion/eversion in patients with a fused hindfoot [37].
Future work could examine the effect of normalizing gait asymmetry on long-term outcomes following TAR. Additional work should focus on gait changes following TAR, as well as on gait symmetry results when comparing fixed and mobile-bearing implants to better assess the overall viability of modern TAR prostheses as a long-term solution for the treatment of severe, painful ankle OA.
The first- and second-generation ankle prostheses were cemented and constrained, which led to higher failure rates [11, 12]. With continuously improving design and fewer constraints, third-generation ankle implants are increasingly favored; however, the technical demands of TAR are substantial. There are still some complications that the surgeon should treat carefully. The recorded complication rate of TAR was 23%, while intraoperative bone fracture and wound healing had a failure rate of at least 50% [38]. The short-term complications of TAR included intraoperative malleolar fractures and skin necrosis. The mid-term clinical outcomes showed a 41% complication rate including instability, infections, subtalar arthritis, malalignment, and one tibial bone cyst, which led to the need for subsequent surgery. Adequate patient selection and a thorough knowledge of associated complications are mandatory to reduce the number of complications and increase the rates of ankle replacement survivorship [39, 40].
M.A. Glazebrook classified the complications following TAR into three tiers: high-grade, medium-grade, and low-grade. High-grade complications result in a greater than 50% failure rate in TAR, including deep infection, aseptic loosening, and implant failure. Medium-grade complications are defined as technical error, subsidence, and postoperative bone fracture. Finally, low-grade complications are defined as intraoperative bone fractures and wound healing problems, which should be considered [41]. Recently, R.J. Gad thought that the three-grade classification system of complications did not reliably reflect practitioners’ experiences, and they thus categorized complications as either high or low risk for the early failure of TAR [38].
Initial clinical results were poor, largely because of early loosening [42, 43]. Aseptic loosening is the predominant failure mechanism in TAR; in fact, A. Henricson reported that about 40% of revision cases are due to aseptic loosening [44]. Primary stability may be affected by the initial implant fixation; in addition, known uncemented talar designs rely on bone ingrowth for fixation, which requires minimal relative motion between the implant and the host bone.
The greater magnitudes of relative motion in the Agility prosthesis suggest that primary instability of the implant may contribute to its higher clinically observed aseptic loosening rate. However, large motions at the bone–implant interface, resulting from a weak initial fixation, may inhibit implant osseointegration early in the healing process and contribute to the overall likelihood of failure resulting from aseptic loosening [19]. Future TAR designs will require better fixation to improve outcomes.
Implant migration is a good clinical evaluation tool for the loosening of prosthesis following TAR. Implant migration was defined as a change in implant location from the immediate postoperative radiograph. J.W.-Y. Fong designed a radiostereometric analysis marker insertion protocol to evaluate the stability of the migration of a fixed-bearing design following TAR [45]. The results showed that the migration of a fixed-bearing design was within the normal range.
S.A. Brigido presented a measurement technique to assess implant migration, which was supported by the high level of inter-rater reliability and intraclass correlation. The results showed that the mean INBONETM implant migration was 0.7 mm at 1 year and 1.0 mm at 2 years. Time and sex were significant predictors of implant migration [3].
Although talar subsidence and migration are recognized complications, empirical observations of postoperative patients with a Salto Talaris ankle replacement have suggested a high rate of posterior bony overhang and resultant overgrowth. In addition, it has been noted that a relatively high percentage of these implants were inserted at an angle other than perpendicular to the anatomic axis of the tibia. Specifically, the implants were usually placed in varus and with a positive slope [35].
Inlay fractures are relatively common, which indicates potential for the improvement of implants. The documentation of intraoperative surgical errors leading to revision surgery varies significantly among registers [46]. The results of the present study indicate a high incidence of hypertrophic bone proliferation when the dimensions of the tibial component do not match the anteroposterior depth of the tibia at the plane of resection. Despite the high occurrence rate, the clinical relevance of hypertrophic bone is obscure. After insertion, the position of the components is not expected to change. Disruption of the extraosseous talar blood supply at the time of ankle replacement may be a factor contributing to talar component subsidence—a common mechanism of early failure following ankle replacement [39].
The stable biological coating of prosthesis components and high initial structural stability is critical for successful TAR. Continuing observation of patients who have undergone TAR is warranted for the purpose of conducting long-term analysis of prosthesis failures in order to improve the outcomes associated with this surgical technique.
Deep infection rates following TAR have been reported to be as high as 4.6% [47]. M.S. Myerson retrospectively reported on the patient- and prosthesis-associated demographics of infected TAR and the outcomes following treatment. The results showed that the treatment of deep infections following TAR is dependent on an accurate and timely diagnosis. A more uniform diagnostic approach, including immediate ankle joint aspiration and the evaluation of inflammatory markers before starting antibiotics, may allow for early surgical intervention, as well as for improved monitoring of a patient’s response to treatment. Only a limited number of patients who develop a deep infection following primary or revision TAR can expect to undergo successful joint-preserving revision arthroplasty. However, hindfoot arthrodesis with intramedullary fixation and structural allograft may be a reliable alternative [48].
Patients with a body mass index higher than 30 showed a higher rate of complications after TAR. Cardiovascular and peripheral vascular disease, smoking, osteoporosis, and overweight are risk factors for a worse survival rate. Preoperative MRI and long-leg X-rays to evaluate any angular deformities of other joints are recommended. Additionally, angiography and neurological examination is recommended for selected patients.
In conclusion, adequate patient selection and thorough knowledge of the surgical technique used are mandatory to reduce the number of complications and to increase ankle replacement survivorship.
Design improvements have increased the success of TAR; revision rates of TAR are higher than those for hip and knee replacement. The revision rates of TAR are approximately 10%–17% at 5 years [38, 40]. In the current cohort of STAR patients, implant survival at a minimum of 10 years of follow-up was high. However, 39% of patients required some sort of secondary procedure, most of which occurred after 9 years of follow-up [17]. A. Henricson et al. defined ankle replacement revision as the extraction of one or more bone-incorporated components or the exchange of a broken plastic component without any known trauma’ [49, 50]. Based on the definition, the authors classified the revision of TAR as having either mechanical causes or nonmechanical causes.
Malalignment and periprosthetic fracture are the major sources of mechanical failure in TAR [23]. S. Manegold et al. classified periprosthetic ankle fractures following TAR into three different types, which are based on three items: the cause of the fracture, the anatomic location of the fracture, and prosthesis stability.
The first parameter evaluates the fracture cause—Type 1: an intraoperative fracture; Type 2: a postoperative traumatic fracture; and Type 3: a postoperative stress fracture. The second parameter is the anatomic location of the periprosthetic fracture. The fracture is assigned a letter (A through D). Concomitant injuries involving bimalleolar fractures and diaphyseal lower-leg fractures are classified as AB and BC, respectively. The third parameter involved the stability of the implanted components. If there are no clinical or radiographic signs of implant loosening, or if the fracture does not reach the prosthesis, the implant can be considered stable. In the presence of periprosthetic osteolysis or fracture-related implant loosening, the prosthesis is classified as unstable. This classification is relatively clear and can be conducted on the basis of the treatment options used. However, the effectiveness of the classification system still needs to be confirmed by the treatment results [51].
Coronal plane malalignment at the level of the tibiotalar joint is not uncommon in end-stage ankle arthritis. Restoration of neutral coronal plane alignment is important in TAR. If an ankle joint prosthesis is not well balanced and edge loading occurs, increased contact stresses on the polyethylene insert can result in accelerated polyethylene wear and premature implant failure. Ancillary procedures performed before, during, or after TAR to correct deformities are thus important in preventing failure due to instability in the varus ankle [31].
There are limited choices currently available in the revision of ankle replacements due to the need to correct osteotomy for alignment. However, the “salvage” can be challenging because a lot of bone has been lost. Alternative approaches include direct arthrodesis with shortening, arthrodesis with interposition graft (autograft, allograft, or shape porous metals), or revision ankle replacement with a larger replacement.
The most prevalent cause of non-mechanical revision involves aseptic loosening. Ellington and Myerson provided a grading system that ranged from 1 to 3 to define the severity of talar component subsidence and to predict the outcomes following revision. In grade 1, the subsidence of the talar component is minimal. In grade 2, the talar component has subsided into the talar body, but it has not violated the subtalar joint. In grade 3, the talar component has migrated onto or through the subtalar joint [15, 52].
M.A. Prissel et al. described a technique for the management of extensive talar aseptic osteolysis for the revision of Agility systems with the use of geometric metal-reinforced polymethylmethacrylate cement augmentation. This technique preserves the subtalar joint, provides immediate component stability, and restores component alignment and height [15]. The authors used three or four titanium plasma-coated triangular metallic arthrodesis rods (3 mm or 7 mm) or large-diameter acetabular screws placed in a triangular or quadrangular orientation around the periphery of the remaining talus and the body of the calcaneus. The superior aspects of the rods or screws should create a parallel surface, allowing the talar component to reside at the proper level to restore the anatomic height of the hindfoot and mechanical function of the ankle joint [15].
Collectively, the classification of periprosthetic fractures and the grading system used for component subsidence can facilitate therapeutic decision making, as they allows for the differential analysis of the causes of these conditions; they can also serve as a guide when making the choice between operative and nonoperative treatment options. There were still obvious functional limitations following the revision of TAR, with fewer than half of the patients returning to previous activity levels. However, the revision of TAR is still a cost-effective alternative to other available options and it still allows for additional revision should late failure occur.
Patients with ankle arthritis and deformity who experience severe pain and functional disability, and do not respond to nonoperative treatment modalities, are candidates for TAR [53]. Currently, there is no consensus regarding which treatment, arthrodesis or replacement, is better for end-stage ankle arthritis.
Ankle arthrodesis is still considered to be the gold standard for the treatment of end-stage ankle arthritis. Ankle arthrodesis yielded good radiographic and functional outcomes in primary arthrodesis [54, 55], bilateral ankle arthrodesis [56], or combined ankle and hindfoot arthrodesis, even in revision cases following TAR [57]. Arthroscopic ankle arthrodesis provides not only an alternative to traditional open techniques but also an obvious advantage including decreased complications, reduced postoperative pain, and shorter hospital stays [58, 59, 60, 61]. There exists fair evidence-based literature (grade B) to support a recommendation for the use of ankle arthroscopy for ankle arthrodesis [62].
Ankle arthrodesis has an approximately 10%–40% nonunion rate [23, 53]. Osteonecrosis of the talus and smoking are known risk factors for nonunion [53]. Risk factors associated with prolonged hospital stay were advanced age, female sex, diabetes mellitus, and more than one general or surgery-related complication [63]. The published literature on the long-term follow-up of modern TAR achieved significantly higher implant survival rates, patient satisfaction, pain relief, and range of motion (ROM) and American Orthopaedic Foot and Ankle Society (AOFAS) scores following the third ankle prosthesis [29, 64]. Complication and survivorship rates were comparable between both groups [65]. Compared to arthrodesis, the primary advantages of TAR include maintenance of motion of the ankle and reduced risk of developing adjacent joint arthritis. J.J. Jiang reported that TAR was independently associated with a lower risk of blood transfusion, non-home discharge, and overall complications when compared to ankle arthrodesis during the index hospitalization period. TAR was also independently associated with a higher hospitalization charge, but the length of stay was similar between the two groups [66]. S. Singer reported that improvement in patient-reported Ankle Osteoarthritis Scale and Short Form-36 scores were similar for both arthrodesis and TAR groups [24]. In addition, R. Rodrigues-Pinto reported that complication and survivorship rates were comparable between both TAR arthrodesis groups [65]. A multicenter study showed that the intermediate-term clinical outcomes of TAR with third-generation prostheses were comparable in a diverse cohort in which treatment was tailored to patient presentation; the rates of reoperation and major complications were higher following ankle replacement when compared with arthrodesis [67].
Although the AOFAS hindfoot scale is the most frequently used outcome instrument in TAR studies, its score has been under recent scrutiny with respect to its moderate level of correlation, its satisfactory degree of reliability, and its degree of responsiveness [68, 69, 70]. The SF-36 and Visual Analog Scale (VAS) pain scoring systems are generic, but validated, outcome measures. Therefore, it will be essential to standardize data collection, evaluation, publication, and the assessment of register data in TAR. TAR outcome measurement by means of registers has several specific requirements necessitating additional documentation beyond the basic dataset [46].
In conclusion, the current investigation demonstrated that neither arthrodesis nor TAR replicated normal ankle function, and there were no differences in ankle power, moments, or temporal gait parameters between the two patient groups. Both arthrodesis and TAR achieved good clinical outcomes. Compared with ankle arthrodesis, the rates of complication with TAR are comparable. Although complications following TAR are frequent, the results of TAR are improving and promising; TAR can reliably improve a person’s quality of life. Nevertheless, patient selection and education are essential.
TAR is becoming the modality of choice for the treatment of end-stage degenerative joint disease of the ankle. To maintain the longest function of ankle replacements, the design of the prosthesis should allow for smooth and continuous interaction and normal gait. TAR offers better mobility, improved gait, and reduces the development of subsequent subtalar joint arthritis when compared with ankle arthrodesis. The decision to treat with TAR or ankle arthrodesis depends on the surgeon’s technique, as well as on the patient’s condition. Improved operative techniques, the surgeon’s experience, as well as appropriate patient selection can anticipate better outcomes. Deformities of the ankle and foot should be corrected before TAR is performed. The revision of a replacement is ultimately inevitable due to aseptic loosening and infection. Despite the functional limitations following the revision of TAR, the revision still offers a cost-effective alternative to ankle arthrodesis.
An ideal three degrees of freedom system that is equivalent with the modal behavior of an infinity number of degree of freedom of two cases of pendulums is proposed for each case. The first pendulum has hinges at the two ends, while the second pendulum is a cantilever (inverted pendulum). Both pendulums are presented analytically in the present article. This equivalent three DoF system can be used in instrumentation of such pendulums, where the concept of the concentrated masses is not existing, with a local network of three accelerometers. This issue is a main problem that appears very common during the instrumentation of inverted pendulums or bridge beams or steel stairs [1, 2, 3] or wind energy powers [4, 5] in order to identify the real vibration mode-shapes and the fundamental eigen-frequencies of the structure via records of response accelerograms at specific positions due to ambient excitation [6, 7].
According to the theory of continuous systems [8, 9], consider a straight amphi-hinge vertical pendulum that is loaded by an external continuous dynamic loading
Amphi-hinge vertical pendulum with distributed mass and section flexural stiffness.
The vertical pendulum possesses a distributed mass
where the resulting force
Furthermore, according to D’Alembert principle, the resulting inertia force
Here, we agree that the time derivatives of the displacements are going to symbolize with full stops, while the spatial derivatives of the displacements are going to symbolize with accent. Next, the damping and the second order differential are ignored, so the force equilibrium on the infinitesimal part of the beam along z-axis gives:
Moreover, the moment equilibrium with reference to weight center (w.c.) of the infinitesimal part of the beam (see Figure 1) gives:
According to Euler-Bernoulli Bending theory (where the shear deformations are ignored), it is well-known that the following basic equation is true:
Eqs. (4) and (5) are inserted into Eq. (3), so the motion equation without damping for the examined vertical beam is given:
Eq. (6) is a partial differential equation that describes the motion
Amphi-hinge vertical pendulum subjected with the same horizontal ground motion ugt on the two end-supports.
where
But, it is known that the inertia forces of the beam are depended by the total displacement
Following, Eqs. (4) and (5) are inserting into Eq. (8), thus we are taken:
By the comparison of Eqs. (6) and (9), we notice that the undamped beam vibration due to horizontal motion of the two supports is mathematically equivalent with the undamped vibration of the same beam where the two supports are fixed and the beam is loaded with the equivalent distributed dynamic loading
In the case of the horizontal pendulum/beam free vibration without damping, we consider the first part of Eq. (9) that must be null:
Furthermore, we ask the unknown spatial time-function
where
Eqs. (13) are inserted into Eq. (11), giving:
and, next, divided with the number
The left part of Eq. (15) is a time-function, but the right part is a spatial-function. In order to true Eq. (15) for all time values as well as for all spatial positions, the two parts of Eq. (15) must be equal with a constant
However, the time equation (16) indicates a free vibration of an ideal single degree of freedom system that has eigen-frequency
Next, we set the positive parameter
because the parameters
where the four unknown parameters
The spatial function of the modal elastic line for
and also for
Eq. (20) has been derived two times with reference to spatial-dimension x, thus arise:
and
Therefore, Eq. (23) is transformed:
By Eqs. (22) and (26) directly arise
In addition, the parameters
In continuous, Eq. (23) gives:
where
However, when Eqs. (28) and (30) are re-written again, we get:
And added part to part these two above-mentioned equations arise:
But, the term
Moreover, by Eq. (34) arise that either
However, Eq. (35) is transformed to Eq. (36):
By the definition of parameter
Thus, inserting Eq. (36) into Eq. (37), the eigen-frequency
Therefore, the vibration mode-shape of the examined vertical pendulum arises by Eq. (27)—since previous inserting Eq. (35)—thus:
The value of
Modal analysis of continuous amphi-hinge vertical pendulum. The first four mode-shapes.
At vertical pendulums or beams where the fundamental horizontal mode-shape does not activate the 90% of the total beam mass, we ask to consider the three first mode-shapes. Thus, for this purpose, we must define an ideal equivalent three degrees of freedom beam, which is going to give the first three frequencies and the first three mode-shapes of the examined beam. Therefore, which is the ideal three degrees of freedom system, where its three mode-shapes coincide with the real first three frequencies of the vertical pendulum with distributed mass and flexural stiffness?
In order to answer the above-mentioned question, consider a weightless vertical pendulum with height L and constant section in elevation, where carry three concentrated masses that each one has the same mass-value
The equivalent three-degree of freedom system on amphi-hinge vertical pendulum.
The pendulum displacement vector u of the three degrees of freedom, as well as the diagonal beam mass matrix
Furthermore, the pendulum flexibility matrix
The equations of motion for the case of the free undamped vibration of the ideal beam is given as:
The eigen-problem is written as:
where the eigen-frequencies
where
The numerical solution of Eq. (46) gives three roots for parameter
Therefore, inserting the ideal equivalent mass
By the previous mathematic analysis, an ideal three degrees of freedom system that is equivalent with the modal behavior of the amphi-hinge vertical pendulum with distributed mass and flexural stiffness along its height has been presented. This ideal three degrees of freedom system can be used in instrumentation of a such vertical tower, which does not possess concentrated masses. In the framework of the identification of mode-shapes of an amphi-hinge pendulum, the equivalent mass by Eq. (47) permits to locate accelerometers per 0.25L (as shown at Figure 4) and there measure the response horizontal acceleration histories, in order to calculate the real first three mode-shapes of the vertical pendulum in order to avoid the instability and resonance-vibrations between the examined vertical pendulum and the supported rockets or space bus before the last launched.
According to the theory of continuous systems [8, 9], consider a straight vertical cantilever (inverted pendulum) that is loaded by an external continuous dynamic loading
Vertical cantilever (inverted pendulum) with distributed mass and section flexural stiffness.
The vertical inverted pendulum possesses a distributed mass
The infinitesimal length of this part is the
and
Moreover, for the free end at
and
However, re-writing Eqs. (50) and (51) again, we get the matrix form:
Eq. (52) is a real eigenvalue problem. In order to calculate the eigenvalues, parameters
However, Eq. (54) can be solved numerically only, where we obtain the first four roots (
By the definition of parameter
Thus, inserting Eq. (54) into Eq. (55), the first four eigen-frequency
Therefore, the vibration mode-shape of the examined vertical inverted pendulum arises by Eq. (20)—since previous inserting Eq. (56)—thus:
The value of
Modal analysis of continuous inverted pendulum. The first four mode-shapes.
At inverted pendulums cantilevers, where the fundamental horizontal mode-shape does not activate the 90% of the total cantilever mass, we ask to consider the three first mode-shapes. Thus, for this purpose, we must define an ideal equivalent three degrees of freedom beam, which is going to give the three mode-shapes of the examined beam. Therefore, which is the ideal three degrees of freedom system, where its three eigen-frequencies coincide with the real first three frequencies of the inverted pendulum with distributed mass and flexural stiffness?
In order to answer the above-mentioned question, consider a weightless vertical inverted pendulum with height L and constant section in elevation, where carry three concentrated masses that each one has the same mass-value
The equivalent three-degree of freedom system on inverted pendulum.
The inverted pendulum displacement vector u of the three degrees of freedom, as well as the diagonal beam mass matrix
Furthermore, the inverted pendulum flexibility matrix
The equations of motion for the case of the free undamped vibration of the ideal beam is given as:
The eigen-problem is written as:
where the eigen-frequencies
where
The numerical solution of Eq. (64) gives three roots for parameter
Therefore, inserting the ideal equivalent mass
On the contrary to above-mentioned about the examined cantilever, it is worth noting that in the case where ask an ideal single degree of freedom system that has eigen-frequency equal to fundamental eigen-frequency of the real cantilever we write the following equations:
Eigen-frequency of single degree of freedom system with k the cantilever lateral stiffness and
Fundamental (first) eigen-frequency (see Eq. (56)) of the real cantilever with continuous distribution of mass and flexural stiffness:
Thus, inserting Eq. (67) into Eq. (66) the equivalent concentrated mass
The present article has presented a mathematic ideal three degrees of freedom system that is equivalent with the modal behavior of two cases of pendulums. First, an amphi-hinge vertical pendulum with distributed mass and flexural stiffness along its height has been examined. Second, an inverted pendulum that can be simulates a tower (or cantilever) has been examined too. For each case, an ideal three degrees of freedom system has been proposed that can be used in instrumentation of such a vertical tower, which does not possess concentrated masses. In the framework of the identification of mode-shapes of the above-mentioned pendulums, the equivalent mass by Eqs. (47) and (65) permits to locate accelerometers (as shown at Figures 4 and 7) and measures the response acceleration histories, in order to calculate the real first three frequencies.
The author wishes to acknowledge the German Research Foundation (DFG) program on Initiation of International Collaboration entitled “Data-driven analysis models for slender structures using explainable artificial intelligence”, Project No. 417973400 for the period 2019–2021, Prof. Dr.-Ing. Kay Smarsly, Bauhaus University Weimar, project coordinator.
The Edited Volume, also known as the IntechOpen Book, is an IntechOpen pioneered publishing product. Edited Volumes make up the core of our business - and as pioneers and developers of this Open Access book publishing format, we have helped change the way scholars and scientists publish their scientific papers - as scientific chapters.
",metaTitle:"Edited Volumes",metaDescription:"The Edited Volume, also known as the InTechOpen Book, is an InTechOpen pioneered publishing product. Edited Volumes make up the core of our business - and as pioneers and developers of this Open Access book publishing format, we have helped change the way scholars and scientists publish their scientific papers - as scientific chapters. ",metaKeywords:null,canonicalURL:"/pages/edited-volumes",contentRaw:'[{"type":"htmlEditorComponent","content":"WHY PUBLISH IN AN INTECHOPEN EDITED VOLUME?
\\n\\nOut of all of the publishing options available to researchers, why choose to contribute your research to an IntechOpen Edited Volume? The reasons are simple. IntechOpen has worked exceptionally hard over the past years to fine tune the Open Access book publishing process and we continue to work hard to deliver the best for all of our contributors. The quality of published content is of utmost importance to us, followed closely by speed, and of course, availability and accessibility. To view current Open Access book projects that are Open for Submissions visit us here.
\\n\\nQUALITY CONTENT
\\n\\nOver the years we have learned what is important. What makes a difference to the researchers that work with us, what they value. Something that is very high not only on their lists, but our own, is the quality of the published content.
\\n\\nOur books contain scientific content written by two Nobel Prize winners, two Breakthrough Prize winners and 73 authors who are in the top 1% Most Cited.
\\n\\nWith regular submission for coverage in the single most important database, the Book Citation Index in the Web of Science™ Core Collection (BKCI), and no rejected submissions to date, over 43% of all Open Access books indexed in the BKCI are IntechOpen published books.
\\n\\nIn addition to BKCI, IntechOpen covers a number of important discipline specific databases as well, such as Thomson Reuters’ BIOSIS Previews.
\\n\\nACCESS
\\n\\nThe need for up to date information available at the click of a mouse is one thing that sets IntechOpen apart. By developing our own technologies in order to streamline the publishing process, we are able to minimize the amount of time from initial submission of a manuscript to its final publication date, without compromising the rigor of the editorial and peer review process. This means that the research published stays relevant, and in this fast paced world, this is very important.
\\n\\nYOUR WORK, YOUR COPYRIGHT
\\n\\nThe utilization of CC licenses allow researchers to retain copyright to their work. Researchers are free to use, adapt and share all content they publish with us. You will never have to pay permission fees to reuse a part of an experiment that you worked so hard to complete and are free to build upon your own research and the research of others. The Edited Volume helps bring together research from all over the world and compiles that research into one book - accessible for all. The research presented in chapter one can inspire the author of chapter three to take his or her research to the next level. It is about sharing ideas, insights and knowledge.
\\n\\nCan collaboration be inspired by a publishing format? At IntechOpen, the answer is yes. The way the research is published, the way it is accessed, it’s all part of our mission to help academics make a greater impact by giving readers free access to all published work.
\\n\\nOur Open Access book collection includes:
\\n\\n3,332 OPEN ACCESS BOOKS
\\n\\n107,564 INTERNATIONAL AUTHORS AND ACADEMIC EDITORS
\\n\\n113+ MILLION DOWNLOADS
\\n\\nPUBLISHING PROCESS STEPS
\\n\\nSee a complete overview of all publishing process steps and descriptions here.
\\n\\nCURRENT PROJECTS
\\n\\nTo view current Open Access book projects that are Open for Submissions visit us here.
\\n\\nNot sure if this is the right publishing option for you? Feel free to contact us at book.department@intechopen.com.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'WHY PUBLISH IN AN INTECHOPEN EDITED VOLUME?
\n\nOut of all of the publishing options available to researchers, why choose to contribute your research to an IntechOpen Edited Volume? The reasons are simple. IntechOpen has worked exceptionally hard over the past years to fine tune the Open Access book publishing process and we continue to work hard to deliver the best for all of our contributors. The quality of published content is of utmost importance to us, followed closely by speed, and of course, availability and accessibility. To view current Open Access book projects that are Open for Submissions visit us here.
\n\nQUALITY CONTENT
\n\nOver the years we have learned what is important. What makes a difference to the researchers that work with us, what they value. Something that is very high not only on their lists, but our own, is the quality of the published content.
\n\nOur books contain scientific content written by two Nobel Prize winners, two Breakthrough Prize winners and 73 authors who are in the top 1% Most Cited.
\n\nWith regular submission for coverage in the single most important database, the Book Citation Index in the Web of Science™ Core Collection (BKCI), and no rejected submissions to date, over 43% of all Open Access books indexed in the BKCI are IntechOpen published books.
\n\nIn addition to BKCI, IntechOpen covers a number of important discipline specific databases as well, such as Thomson Reuters’ BIOSIS Previews.
\n\nACCESS
\n\nThe need for up to date information available at the click of a mouse is one thing that sets IntechOpen apart. By developing our own technologies in order to streamline the publishing process, we are able to minimize the amount of time from initial submission of a manuscript to its final publication date, without compromising the rigor of the editorial and peer review process. This means that the research published stays relevant, and in this fast paced world, this is very important.
\n\nYOUR WORK, YOUR COPYRIGHT
\n\nThe utilization of CC licenses allow researchers to retain copyright to their work. Researchers are free to use, adapt and share all content they publish with us. You will never have to pay permission fees to reuse a part of an experiment that you worked so hard to complete and are free to build upon your own research and the research of others. The Edited Volume helps bring together research from all over the world and compiles that research into one book - accessible for all. The research presented in chapter one can inspire the author of chapter three to take his or her research to the next level. It is about sharing ideas, insights and knowledge.
\n\nCan collaboration be inspired by a publishing format? At IntechOpen, the answer is yes. The way the research is published, the way it is accessed, it’s all part of our mission to help academics make a greater impact by giving readers free access to all published work.
\n\nOur Open Access book collection includes:
\n\n3,332 OPEN ACCESS BOOKS
\n\n107,564 INTERNATIONAL AUTHORS AND ACADEMIC EDITORS
\n\n113+ MILLION DOWNLOADS
\n\nPUBLISHING PROCESS STEPS
\n\nSee a complete overview of all publishing process steps and descriptions here.
\n\nCURRENT PROJECTS
\n\nTo view current Open Access book projects that are Open for Submissions visit us here.
\n\nNot sure if this is the right publishing option for you? Feel free to contact us at book.department@intechopen.com.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/55578/images/4574_n.png",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:5681},{group:"region",caption:"Middle and South America",value:2,count:5160},{group:"region",caption:"Africa",value:3,count:1683},{group:"region",caption:"Asia",value:4,count:10200},{group:"region",caption:"Australia and Oceania",value:5,count:886},{group:"region",caption:"Europe",value:6,count:15608}],offset:12,limit:12,total:117095},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{sort:"dateEndThirdStepPublish",topicId:"5,6,9"},books:[{type:"book",id:"10391",title:"Ambient Intelligence",subtitle:null,isOpenForSubmission:!0,hash:"3fbf8f0bcc5cdff72aaf0949d7cbc12e",slug:null,bookSignature:"Dr. Carmine Massarelli",coverURL:"https://cdn.intechopen.com/books/images_new/10391.jpg",editedByType:null,editors:[{id:"315689",title:"Dr.",name:"Carmine",surname:"Massarelli",slug:"carmine-massarelli",fullName:"Carmine Massarelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10652",title:"Visual Object Tracking",subtitle:null,isOpenForSubmission:!0,hash:"96f3ee634a7ba49fa195e50475412af4",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10653",title:"Optimization Algorithms",subtitle:null,isOpenForSubmission:!0,hash:"753812dbb9a6f6b57645431063114f6c",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10653.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10651",title:"Machine Learning",subtitle:null,isOpenForSubmission:!0,hash:"5806b4efae3bd91c3f56e64e0442df35",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10651.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10748",title:"Fishery",subtitle:null,isOpenForSubmission:!0,hash:"ecde44e36545a02e9bed47333869ca6f",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10748.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10693",title:"Open Data",subtitle:null,isOpenForSubmission:!0,hash:"9fcbb8e096da084fb29d8f16aaecb061",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10693.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10240",title:"Post-Translational Modifications in Cellular Functions and Diseases",subtitle:null,isOpenForSubmission:!0,hash:"27349927a8f626359f696ba5472bc2b2",slug:null,bookSignature:"Ph.D. Shibo Ying",coverURL:"https://cdn.intechopen.com/books/images_new/10240.jpg",editedByType:null,editors:[{id:"306153",title:"Ph.D.",name:"Shibo",surname:"Ying",slug:"shibo-ying",fullName:"Shibo Ying"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10738",title:"Molluscs",subtitle:null,isOpenForSubmission:!0,hash:"a42a81ed3f9e3dda6d0daaf69c26117e",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10738.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10271",title:"Software Usability",subtitle:null,isOpenForSubmission:!0,hash:"8c71aff43977a455e7563255a2c104b1",slug:null,bookSignature:"Dr. Laura M. M. Castro and Dr. David Cabrero",coverURL:"https://cdn.intechopen.com/books/images_new/10271.jpg",editedByType:null,editors:[{id:"151757",title:"Dr.",name:"Laura M.",surname:"Castro",slug:"laura-m.-castro",fullName:"Laura M. Castro"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10694",title:"Genetic Algorithms",subtitle:null,isOpenForSubmission:!0,hash:"91c5491dc248333f624d1d35e590ba45",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10694.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10743",title:"Whey Proteins",subtitle:null,isOpenForSubmission:!0,hash:"7d393c7da4db5af690c1b60a23011fe7",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10743.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10768",title:"Bryology and Lichenology",subtitle:null,isOpenForSubmission:!0,hash:"2188e0dffab6ad8d6c0f3afce29ccce0",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/10768.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:9},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:18},{group:"topic",caption:"Business, Management and Economics",value:7,count:2},{group:"topic",caption:"Chemistry",value:8,count:8},{group:"topic",caption:"Computer and Information Science",value:9,count:12},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:5},{group:"topic",caption:"Engineering",value:11,count:17},{group:"topic",caption:"Environmental Sciences",value:12,count:2},{group:"topic",caption:"Immunology and Microbiology",value:13,count:6},{group:"topic",caption:"Materials Science",value:14,count:5},{group:"topic",caption:"Mathematics",value:15,count:1},{group:"topic",caption:"Medicine",value:16,count:69},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:1},{group:"topic",caption:"Neuroscience",value:18,count:1},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:3},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:3},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:73},popularBooks:{featuredBooks:[{type:"book",id:"9343",title:"Trace Metals in the Environment",subtitle:"New Approaches and Recent Advances",isOpenForSubmission:!1,hash:"ae07e345bc2ce1ebbda9f70c5cd12141",slug:"trace-metals-in-the-environment-new-approaches-and-recent-advances",bookSignature:"Mario Alfonso Murillo-Tovar, Hugo Saldarriaga-Noreña and Agnieszka Saeid",coverURL:"https://cdn.intechopen.com/books/images_new/9343.jpg",editors:[{id:"255959",title:"Dr.",name:"Mario Alfonso",middleName:null,surname:"Murillo-Tovar",slug:"mario-alfonso-murillo-tovar",fullName:"Mario Alfonso Murillo-Tovar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7769",title:"Medical Isotopes",subtitle:null,isOpenForSubmission:!1,hash:"f8d3c5a6c9a42398e56b4e82264753f7",slug:"medical-isotopes",bookSignature:"Syed Ali Raza Naqvi and Muhammad Babar Imrani",coverURL:"https://cdn.intechopen.com/books/images_new/7769.jpg",editors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9376",title:"Contemporary Developments and Perspectives in International Health Security",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"b9a00b84cd04aae458fb1d6c65795601",slug:"contemporary-developments-and-perspectives-in-international-health-security-volume-1",bookSignature:"Stanislaw P. Stawicki, Michael S. Firstenberg, Sagar C. Galwankar, Ricardo Izurieta and Thomas Papadimos",coverURL:"https://cdn.intechopen.com/books/images_new/9376.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7831",title:"Sustainability in Urban Planning and Design",subtitle:null,isOpenForSubmission:!1,hash:"c924420492c8c2c9751e178d025f4066",slug:"sustainability-in-urban-planning-and-design",bookSignature:"Amjad Almusaed, Asaad Almssad and Linh Truong - Hong",coverURL:"https://cdn.intechopen.com/books/images_new/7831.jpg",editors:[{id:"110471",title:"Dr.",name:"Amjad",middleName:"Zaki",surname:"Almusaed",slug:"amjad-almusaed",fullName:"Amjad Almusaed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9279",title:"Concepts, Applications and Emerging Opportunities in Industrial Engineering",subtitle:null,isOpenForSubmission:!1,hash:"9bfa87f9b627a5468b7c1e30b0eea07a",slug:"concepts-applications-and-emerging-opportunities-in-industrial-engineering",bookSignature:"Gary Moynihan",coverURL:"https://cdn.intechopen.com/books/images_new/9279.jpg",editors:[{id:"16974",title:"Dr.",name:"Gary",middleName:null,surname:"Moynihan",slug:"gary-moynihan",fullName:"Gary Moynihan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7807",title:"A Closer Look at Organizational Culture in Action",subtitle:null,isOpenForSubmission:!1,hash:"05c608b9271cc2bc711f4b28748b247b",slug:"a-closer-look-at-organizational-culture-in-action",bookSignature:"Süleyman Davut Göker",coverURL:"https://cdn.intechopen.com/books/images_new/7807.jpg",editors:[{id:"190035",title:"Associate Prof.",name:"Süleyman Davut",middleName:null,surname:"Göker",slug:"suleyman-davut-goker",fullName:"Süleyman Davut Göker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7796",title:"Human 4.0",subtitle:"From Biology to Cybernetic",isOpenForSubmission:!1,hash:"5ac5c052d3a593d5c4f4df66d005e5af",slug:"human-4-0-from-biology-to-cybernetic",bookSignature:"Yves Rybarczyk",coverURL:"https://cdn.intechopen.com/books/images_new/7796.jpg",editors:[{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9711",title:"Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production",subtitle:null,isOpenForSubmission:!1,hash:"12cf675f1e433135dd5bf5df7cec124f",slug:"pests-weeds-and-diseases-in-agricultural-crop-and-animal-husbandry-production",bookSignature:"Dimitrios Kontogiannatos, Anna Kourti and Kassio Ferreira Mendes",coverURL:"https://cdn.intechopen.com/books/images_new/9711.jpg",editors:[{id:"196691",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Kontogiannatos",slug:"dimitrios-kontogiannatos",fullName:"Dimitrios Kontogiannatos"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10178",title:"Environmental Emissions",subtitle:null,isOpenForSubmission:!1,hash:"febf21ec717bfe20ae25a9dab9b5d438",slug:"environmental-emissions",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/10178.jpg",editors:[{id:"103742",title:"Dr.",name:"Richard",middleName:null,surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8511",title:"Cyberspace",subtitle:null,isOpenForSubmission:!1,hash:"8c1cdeb133dbe6cc1151367061c1bba6",slug:"cyberspace",bookSignature:"Evon Abu-Taieh, Abdelkrim El Mouatasim and Issam H. Al Hadid",coverURL:"https://cdn.intechopen.com/books/images_new/8511.jpg",editors:[{id:"223522",title:"Dr.",name:"Evon",middleName:"M.O.",surname:"Abu-Taieh",slug:"evon-abu-taieh",fullName:"Evon Abu-Taieh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9534",title:"Banking and Finance",subtitle:null,isOpenForSubmission:!1,hash:"af14229738af402c3b595d7e124dce82",slug:"banking-and-finance",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",editors:[{id:"206517",title:"Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:5124},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9343",title:"Trace Metals in the Environment",subtitle:"New Approaches and Recent Advances",isOpenForSubmission:!1,hash:"ae07e345bc2ce1ebbda9f70c5cd12141",slug:"trace-metals-in-the-environment-new-approaches-and-recent-advances",bookSignature:"Mario Alfonso Murillo-Tovar, Hugo Saldarriaga-Noreña and Agnieszka Saeid",coverURL:"https://cdn.intechopen.com/books/images_new/9343.jpg",editors:[{id:"255959",title:"Dr.",name:"Mario Alfonso",middleName:null,surname:"Murillo-Tovar",slug:"mario-alfonso-murillo-tovar",fullName:"Mario Alfonso Murillo-Tovar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7769",title:"Medical Isotopes",subtitle:null,isOpenForSubmission:!1,hash:"f8d3c5a6c9a42398e56b4e82264753f7",slug:"medical-isotopes",bookSignature:"Syed Ali Raza Naqvi and Muhammad Babar Imrani",coverURL:"https://cdn.intechopen.com/books/images_new/7769.jpg",editors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9376",title:"Contemporary Developments and Perspectives in International Health Security",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"b9a00b84cd04aae458fb1d6c65795601",slug:"contemporary-developments-and-perspectives-in-international-health-security-volume-1",bookSignature:"Stanislaw P. Stawicki, Michael S. Firstenberg, Sagar C. Galwankar, Ricardo Izurieta and Thomas Papadimos",coverURL:"https://cdn.intechopen.com/books/images_new/9376.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7831",title:"Sustainability in Urban Planning and Design",subtitle:null,isOpenForSubmission:!1,hash:"c924420492c8c2c9751e178d025f4066",slug:"sustainability-in-urban-planning-and-design",bookSignature:"Amjad Almusaed, Asaad Almssad and Linh Truong - Hong",coverURL:"https://cdn.intechopen.com/books/images_new/7831.jpg",editors:[{id:"110471",title:"Dr.",name:"Amjad",middleName:"Zaki",surname:"Almusaed",slug:"amjad-almusaed",fullName:"Amjad Almusaed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9279",title:"Concepts, Applications and Emerging Opportunities in Industrial Engineering",subtitle:null,isOpenForSubmission:!1,hash:"9bfa87f9b627a5468b7c1e30b0eea07a",slug:"concepts-applications-and-emerging-opportunities-in-industrial-engineering",bookSignature:"Gary Moynihan",coverURL:"https://cdn.intechopen.com/books/images_new/9279.jpg",editors:[{id:"16974",title:"Dr.",name:"Gary",middleName:null,surname:"Moynihan",slug:"gary-moynihan",fullName:"Gary Moynihan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7807",title:"A Closer Look at Organizational Culture in Action",subtitle:null,isOpenForSubmission:!1,hash:"05c608b9271cc2bc711f4b28748b247b",slug:"a-closer-look-at-organizational-culture-in-action",bookSignature:"Süleyman Davut Göker",coverURL:"https://cdn.intechopen.com/books/images_new/7807.jpg",editors:[{id:"190035",title:"Associate Prof.",name:"Süleyman Davut",middleName:null,surname:"Göker",slug:"suleyman-davut-goker",fullName:"Süleyman Davut Göker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7796",title:"Human 4.0",subtitle:"From Biology to Cybernetic",isOpenForSubmission:!1,hash:"5ac5c052d3a593d5c4f4df66d005e5af",slug:"human-4-0-from-biology-to-cybernetic",bookSignature:"Yves Rybarczyk",coverURL:"https://cdn.intechopen.com/books/images_new/7796.jpg",editors:[{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9711",title:"Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production",subtitle:null,isOpenForSubmission:!1,hash:"12cf675f1e433135dd5bf5df7cec124f",slug:"pests-weeds-and-diseases-in-agricultural-crop-and-animal-husbandry-production",bookSignature:"Dimitrios Kontogiannatos, Anna Kourti and Kassio Ferreira Mendes",coverURL:"https://cdn.intechopen.com/books/images_new/9711.jpg",editors:[{id:"196691",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Kontogiannatos",slug:"dimitrios-kontogiannatos",fullName:"Dimitrios Kontogiannatos"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10178",title:"Environmental Emissions",subtitle:null,isOpenForSubmission:!1,hash:"febf21ec717bfe20ae25a9dab9b5d438",slug:"environmental-emissions",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/10178.jpg",editors:[{id:"103742",title:"Dr.",name:"Richard",middleName:null,surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8511",title:"Cyberspace",subtitle:null,isOpenForSubmission:!1,hash:"8c1cdeb133dbe6cc1151367061c1bba6",slug:"cyberspace",bookSignature:"Evon Abu-Taieh, Abdelkrim El Mouatasim and Issam H. Al Hadid",coverURL:"https://cdn.intechopen.com/books/images_new/8511.jpg",editors:[{id:"223522",title:"Dr.",name:"Evon",middleName:"M.O.",surname:"Abu-Taieh",slug:"evon-abu-taieh",fullName:"Evon Abu-Taieh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8468",title:"Sheep Farming",subtitle:"An Approach to Feed, Growth and Sanity",isOpenForSubmission:!1,hash:"838f08594850bc04aa14ec873ed1b96f",slug:"sheep-farming-an-approach-to-feed-growth-and-sanity",bookSignature:"António Monteiro",coverURL:"https://cdn.intechopen.com/books/images_new/8468.jpg",editedByType:"Edited by",editors:[{id:"190314",title:"Prof.",name:"António",middleName:"Cardoso",surname:"Monteiro",slug:"antonio-monteiro",fullName:"António Monteiro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9523",title:"Oral and Maxillofacial Surgery",subtitle:null,isOpenForSubmission:!1,hash:"5eb6ec2db961a6c8965d11180a58d5c1",slug:"oral-and-maxillofacial-surgery",bookSignature:"Gokul Sridharan",coverURL:"https://cdn.intechopen.com/books/images_new/9523.jpg",editedByType:"Edited by",editors:[{id:"82453",title:"Dr.",name:"Gokul",middleName:null,surname:"Sridharan",slug:"gokul-sridharan",fullName:"Gokul Sridharan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9785",title:"Endometriosis",subtitle:null,isOpenForSubmission:!1,hash:"f457ca61f29cf7e8bc191732c50bb0ce",slug:"endometriosis",bookSignature:"Courtney Marsh",coverURL:"https://cdn.intechopen.com/books/images_new/9785.jpg",editedByType:"Edited by",editors:[{id:"255491",title:"Dr.",name:"Courtney",middleName:null,surname:"Marsh",slug:"courtney-marsh",fullName:"Courtney Marsh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9018",title:"Some RNA Viruses",subtitle:null,isOpenForSubmission:!1,hash:"a5cae846dbe3692495fc4add2f60fd84",slug:"some-rna-viruses",bookSignature:"Yogendra Shah and Eltayb Abuelzein",coverURL:"https://cdn.intechopen.com/books/images_new/9018.jpg",editedByType:"Edited by",editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",middleName:null,surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8816",title:"Financial Crises",subtitle:"A Selection of Readings",isOpenForSubmission:!1,hash:"6f2f49fb903656e4e54280c79fabd10c",slug:"financial-crises-a-selection-of-readings",bookSignature:"Stelios Markoulis",coverURL:"https://cdn.intechopen.com/books/images_new/8816.jpg",editedByType:"Edited by",editors:[{id:"237863",title:"Dr.",name:"Stelios",middleName:null,surname:"Markoulis",slug:"stelios-markoulis",fullName:"Stelios Markoulis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9585",title:"Advances in Complex Valvular Disease",subtitle:null,isOpenForSubmission:!1,hash:"ef64f11e211621ecfe69c46e60e7ca3d",slug:"advances-in-complex-valvular-disease",bookSignature:"Michael S. Firstenberg and Imran Khan",coverURL:"https://cdn.intechopen.com/books/images_new/9585.jpg",editedByType:"Edited by",editors:[{id:"64343",title:null,name:"Michael S.",middleName:"S",surname:"Firstenberg",slug:"michael-s.-firstenberg",fullName:"Michael S. Firstenberg"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10150",title:"Smart Manufacturing",subtitle:"When Artificial Intelligence Meets the Internet of Things",isOpenForSubmission:!1,hash:"87004a19de13702d042f8ff96d454698",slug:"smart-manufacturing-when-artificial-intelligence-meets-the-internet-of-things",bookSignature:"Tan Yen Kheng",coverURL:"https://cdn.intechopen.com/books/images_new/10150.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",middleName:null,surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9386",title:"Direct Numerical Simulations",subtitle:"An Introduction and Applications",isOpenForSubmission:!1,hash:"158a3a0fdba295d21ff23326f5a072d5",slug:"direct-numerical-simulations-an-introduction-and-applications",bookSignature:"Srinivasa Rao",coverURL:"https://cdn.intechopen.com/books/images_new/9386.jpg",editedByType:"Edited by",editors:[{id:"6897",title:"Dr.",name:"Srinivasa",middleName:"P",surname:"Rao",slug:"srinivasa-rao",fullName:"Srinivasa Rao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9139",title:"Topics in Primary Care Medicine",subtitle:null,isOpenForSubmission:!1,hash:"ea774a4d4c1179da92a782e0ae9cde92",slug:"topics-in-primary-care-medicine",bookSignature:"Thomas F. Heston",coverURL:"https://cdn.intechopen.com/books/images_new/9139.jpg",editedByType:"Edited by",editors:[{id:"217926",title:"Dr.",name:"Thomas F.",middleName:null,surname:"Heston",slug:"thomas-f.-heston",fullName:"Thomas F. Heston"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9208",title:"Welding",subtitle:"Modern Topics",isOpenForSubmission:!1,hash:"7d6be076ccf3a3f8bd2ca52d86d4506b",slug:"welding-modern-topics",bookSignature:"Sadek Crisóstomo Absi Alfaro, Wojciech Borek and Błażej Tomiczek",coverURL:"https://cdn.intechopen.com/books/images_new/9208.jpg",editedByType:"Edited by",editors:[{id:"65292",title:"Prof.",name:"Sadek Crisostomo Absi",middleName:"C. Absi",surname:"Alfaro",slug:"sadek-crisostomo-absi-alfaro",fullName:"Sadek Crisostomo Absi Alfaro"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"883",title:"Environmental Policy",slug:"environmental-sciences-sustainable-development-environmental-policy",parent:{title:"Sustainable Development",slug:"environmental-sciences-sustainable-development"},numberOfBooks:1,numberOfAuthorsAndEditors:30,numberOfWosCitations:19,numberOfCrossrefCitations:19,numberOfDimensionsCitations:38,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicSlug:"environmental-sciences-sustainable-development-environmental-policy",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"2016",title:"Sustainable Development",subtitle:"Policy and Urban Development - Tourism, Life Science, Management and Environment",isOpenForSubmission:!1,hash:"2afa6164c067274259fa5c28364e6592",slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",bookSignature:"Chaouki Ghenai",coverURL:"https://cdn.intechopen.com/books/images_new/2016.jpg",editedByType:"Edited by",editors:[{id:"14569",title:"Prof.",name:"Chaouki",middleName:null,surname:"Ghenai",slug:"chaouki-ghenai",fullName:"Chaouki Ghenai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,mostCitedChapters:[{id:"29237",doi:"10.5772/26626",title:"Innovation Ecosystem for Sustainable Development",slug:"innovation-ecosystem-for-sustainable-development",totalDownloads:2306,totalCrossrefCites:3,totalDimensionsCites:7,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Kayano Fukuda and Chihiro Watanabe",authors:[{id:"67348",title:"Dr.",name:"Kayano",middleName:null,surname:"Fukuda",slug:"kayano-fukuda",fullName:"Kayano Fukuda"},{id:"128853",title:"Prof.",name:"Chihiro",middleName:null,surname:"Watanabe",slug:"chihiro-watanabe",fullName:"Chihiro Watanabe"}]},{id:"29239",doi:"10.5772/26891",title:"The Environment as a Factor of Spatial Injustice: A New Challenge for the Sustainable Development of European Regions?",slug:"the-environment-as-a-factor-of-spatial-injustice-a-new-challenge-for-the-sustainable-development-of-",totalDownloads:2253,totalCrossrefCites:3,totalDimensionsCites:5,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Guillaume Faburel",authors:[{id:"68153",title:"Prof.",name:"Guillaume",middleName:null,surname:"Faburel",slug:"guillaume-faburel",fullName:"Guillaume Faburel"}]},{id:"29238",doi:"10.5772/26942",title:"Unraveling Stakeholders’ Discourses Regarding Sustainable Development and Biodiversity Conservation in Greece",slug:"unraveling-stakeholders-discourses-regarding-sustainable-development-and-biodiversity-conservation-i",totalDownloads:1401,totalCrossrefCites:0,totalDimensionsCites:4,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Evangelia Apostolopoulou, Evangelia G. Drakou, and John D. Pantis",authors:[{id:"68362",title:"Dr.",name:"Evangelia",middleName:null,surname:"Apostolopoulou",slug:"evangelia-apostolopoulou",fullName:"Evangelia Apostolopoulou"},{id:"78446",title:"Dr.",name:"Evangelia",middleName:null,surname:"Drakou",slug:"evangelia-drakou",fullName:"Evangelia Drakou"},{id:"78448",title:"Prof.",name:"John",middleName:null,surname:"Pantis",slug:"john-pantis",fullName:"John Pantis"}]}],mostDownloadedChaptersLast30Days:[{id:"29239",title:"The Environment as a Factor of Spatial Injustice: A New Challenge for the Sustainable Development of European Regions?",slug:"the-environment-as-a-factor-of-spatial-injustice-a-new-challenge-for-the-sustainable-development-of-",totalDownloads:2253,totalCrossrefCites:3,totalDimensionsCites:5,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Guillaume Faburel",authors:[{id:"68153",title:"Prof.",name:"Guillaume",middleName:null,surname:"Faburel",slug:"guillaume-faburel",fullName:"Guillaume Faburel"}]},{id:"29238",title:"Unraveling Stakeholders’ Discourses Regarding Sustainable Development and Biodiversity Conservation in Greece",slug:"unraveling-stakeholders-discourses-regarding-sustainable-development-and-biodiversity-conservation-i",totalDownloads:1401,totalCrossrefCites:0,totalDimensionsCites:4,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Evangelia Apostolopoulou, Evangelia G. Drakou, and John D. Pantis",authors:[{id:"68362",title:"Dr.",name:"Evangelia",middleName:null,surname:"Apostolopoulou",slug:"evangelia-apostolopoulou",fullName:"Evangelia Apostolopoulou"},{id:"78446",title:"Dr.",name:"Evangelia",middleName:null,surname:"Drakou",slug:"evangelia-drakou",fullName:"Evangelia Drakou"},{id:"78448",title:"Prof.",name:"John",middleName:null,surname:"Pantis",slug:"john-pantis",fullName:"John Pantis"}]},{id:"29222",title:"Sustainable Urban Development Through the Empowering of Local Communities",slug:"sustainable-urban-development-through-the-empowering-of-local-communities",totalDownloads:1418,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Radu Radoslav, Marius Stelian Găman, Tudor Morar, Ştefana Bădescu and Ana-Maria Branea",authors:[{id:"69700",title:"Prof.",name:"Radu",middleName:null,surname:"Radoslav",slug:"radu-radoslav",fullName:"Radu Radoslav"}]},{id:"29224",title:"Sustainable Tourism of Destination, Imperative Triangle Among: Competitiveness, Effective Management and Proper Financing",slug:"sustainable-tourism-of-destination-imperative-triangle-among-competitiveness-effective-management-an",totalDownloads:3599,totalCrossrefCites:2,totalDimensionsCites:3,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Mirela Mazilu",authors:[{id:"72582",title:"Prof.",name:"Mirela",middleName:"Elena",surname:"Mazilu",slug:"mirela-mazilu",fullName:"Mirela Mazilu"}]},{id:"29225",title:"Croatian Tourism Development Model – Anatomy of an Un/Sustainability",slug:"croatian-tourism-development-model-anatomy-of-an-un-sustainability",totalDownloads:1904,totalCrossrefCites:1,totalDimensionsCites:2,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Lidija Petrić",authors:[{id:"72730",title:"Prof.",name:"Lidija",middleName:null,surname:"Petrić",slug:"lidija-petric",fullName:"Lidija Petrić"}]},{id:"29227",title:"Sustainability Challenges: Changing Attitudes and a Demand for Better Management of the Tourism Industry in Malaysia",slug:"sustainability-challenges-changing-attitudes-and-a-demand-for-better-management-of-the-tourism-indus",totalDownloads:3268,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Janie Liew-Tsonis and Sharon Cheuk",authors:[{id:"67670",title:"Dr.",name:"Janie",middleName:null,surname:"Liew-Tsonis",slug:"janie-liew-tsonis",fullName:"Janie Liew-Tsonis"},{id:"131050",title:"Ms.",name:"Sharon",middleName:null,surname:"Cheuk",slug:"sharon-cheuk",fullName:"Sharon Cheuk"}]},{id:"29237",title:"Innovation Ecosystem for Sustainable Development",slug:"innovation-ecosystem-for-sustainable-development",totalDownloads:2306,totalCrossrefCites:3,totalDimensionsCites:7,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Kayano Fukuda and Chihiro Watanabe",authors:[{id:"67348",title:"Dr.",name:"Kayano",middleName:null,surname:"Fukuda",slug:"kayano-fukuda",fullName:"Kayano Fukuda"},{id:"128853",title:"Prof.",name:"Chihiro",middleName:null,surname:"Watanabe",slug:"chihiro-watanabe",fullName:"Chihiro Watanabe"}]},{id:"29223",title:"Sustainable Urban Design and Walkable Neighborhoods",slug:"sustainable-urban-design-and-walkable-neighborhoods",totalDownloads:2741,totalCrossrefCites:0,totalDimensionsCites:1,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Theresa Glanz, Yunwoo Nam and Zhenghong Tang",authors:[{id:"69579",title:"Prof.",name:"Zhenghong",middleName:null,surname:"Tang",slug:"zhenghong-tang",fullName:"Zhenghong Tang"}]},{id:"29226",title:"Built Heritage and Sustainable Tourism: Conceptual, Economic and Social Variables",slug:"built-heritage-and-sustainable-tourism-conceptual-economic-and-social-variables",totalDownloads:1939,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Beatriz Amarilla and Alfredo Conti",authors:[{id:"74977",title:"Prof.",name:"Beatriz",middleName:null,surname:"Amarilla",slug:"beatriz-amarilla",fullName:"Beatriz Amarilla"},{id:"78428",title:"Prof.",name:"Alfredo",middleName:null,surname:"Conti",slug:"alfredo-conti",fullName:"Alfredo Conti"}]},{id:"29228",title:"Sustainable Development Global Simulation: Analysis of Quality and Security of Human Life",slug:"sustainable-development-global-simulation-analysis-of-quality-and-security-of-human-life",totalDownloads:1259,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"sustainable-development-policy-and-urban-development-tourism-life-science-management-and-environment",title:"Sustainable Development",fullTitle:"Sustainable Development - Policy and Urban Development - Tourism, Life Science, Management and Environment"},signatures:"Michael Zgurovsky",authors:[{id:"67789",title:"Prof.",name:"Michael",middleName:null,surname:"Zgurovsky",slug:"michael-zgurovsky",fullName:"Michael Zgurovsky"}]}],onlineFirstChaptersFilter:{topicSlug:"environmental-sciences-sustainable-development-environmental-policy",limit:3,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[{type:"book",id:"10176",title:"Microgrids and Local Energy Systems",subtitle:null,isOpenForSubmission:!0,hash:"c32b4a5351a88f263074b0d0ca813a9c",slug:null,bookSignature:"Prof. Nick Jenkins",coverURL:"https://cdn.intechopen.com/books/images_new/10176.jpg",editedByType:null,editors:[{id:"55219",title:"Prof.",name:"Nick",middleName:null,surname:"Jenkins",slug:"nick-jenkins",fullName:"Nick Jenkins"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:8,limit:8,total:1},route:{name:"profile.detail",path:"/profiles/305582/hossam-abd-el-munim",hash:"",query:{},params:{id:"305582",slug:"hossam-abd-el-munim"},fullPath:"/profiles/305582/hossam-abd-el-munim",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var m;(m=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(m)}()