Sabina Janciauskiene

Prof. Dr. Sabina Janciauskiene was born in 1960 in Sweden. Since 1992, overall objective of her research is to investigate the mechanisms controlling inflammation, with particular emphasis on the multiple roles played by serine protease inhibitors (serpins) like: alpha1-antitrypsin and alpha1-antichymotrypsin. Dr. Janciauskiene`s group was among the first to propose that serpin misfolding can also occur due to post-translational modifications of serpin molecule, such as oxidation, nitration, interaction with other molecules and cleavage. Dr. Janciauskiene is a member of the German Lung Research Center and European Respiratory Society. She is a receiver of several prices Teggers Stipendium, King`s Gustaf V & Queen`s Victoria Award and International ALTA "B Laurell Award, for new insights in Alpha1-antitrypsin deficiency field, among others. Dr. Janciauskiene made substantial contributions through publications, book chapters, external oral/poster presentations, organizing conferences, contribution to the diagnostic test research and development, and active participation within the Leonardo Da Vinci educational program in Europe, and collaboration with Alpha1-Antitrypsin deficiency patient organizations in Sweden, Germany, and England

1books edited

2chapters authored

Latest work with IntechOpen by Sabina Janciauskiene

The magnitude and rapidity of the changes in the concentrations of APPs, together with their short half-life, suggest an important role for these proteins in the establishment of host defense. APPs are regarded as having general functions in trapping of micro-organisms and their products, in activating complement, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free radicals, and in modulating the hosts immune response. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their function during health and disease remains incompletely defined.

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