Chapters authored
Modulation of Edible Plants on Hepatocellular Carcinoma Induced by Aflatoxin B1
Aflatoxin B1 (AFB1) is one of the major causes of liver cancer especially hepatocellular carcinoma that has high incidence and mortality rate in many countries. Owing to the climate that is suitable for fungal growth, the avoidance of AFB1 exposure from agricultural product contamination is too difficult. This up-to-date review aims to collect insight on how edible plants attenuate AFB1-toxicity. Cruciferous vegetables, green tea, purple rice, turmeric, green vegetables, ginger, Dialium guineense, Parkia biglobosa, carotenoid-rich fruits and vegetables, Allii Fistulosi Bulbus, and rosemary have reported their capabilities to alleviate AFB1-toxicity though several mechanisms. All these plants showed anti-genotoxic activity while some of them are able to reduce hepatotoxicity, liver cancer, and oxidative stress and modulate metabolism enzymes induced by AFB1. Furthermore, a few edible plants could handle AFB1 in pre-exposure phase including anti-AFB1 biosynthesis and AFB1 absorption. Although the detoxification mechanisms of AFB1 activated by various edible plants have been investigated in pre-clinical study for a decade, clinical trial is still rarely clarified. Further study associating with a protective effect on AFB1 toxicity still needs to be carried out especially in the clinical study.
Part of the book: Phytochemicals in Human Health