Xinhui Wang

Qinghai Normal University

Dr. Xinhui Wang obtained a Ph.D. from the University of Twente, Netherlands, in 2008. Over the years, he has worked in bioinformatics at the Norwegian University of Science and Technology (NTNU), Norway, University Medical Center Utrecht Utrecht (UMC), Netherlands, Radboud University Medical Center, Netherlands, and Academic Medical Center (AMC), Netherlands. His research focuses on multi-clinical omics data analysis, including metagenomics, genomics, immunomics, and transcriptomics data analysis. He has helped develop many statistical tools and machine learning approaches for all kinds of clinical data analysis. He has served as a committee member of more than ten conferences and a reviewer of ten academic peer-reviewed journals.

1books edited

1chapters authored

Latest work with IntechOpen by Xinhui Wang

Candida albicans, a fungal pathobiont, is the major component of the microbiota communities in healthy adults. It resides in the host’s gastrointestinal tract and mouth and can become pathogenic via overgrowth under a variety of conditions. This book reviews recent knowledge and the latest research on C. albicans, including the mechanism of candidiasis infection, host response, antifungal strategies, biofilms, genetics, and molecular epidemiology of immune responses.

Go to the book

Advances in Candida albicans

Edited by Xinhui Wang

Chapters authored

TNFR2 and Regulatory T Cells: Potential Immune Checkpoint Target in Cancer Immunotherapy

By Xuehui He and Xinhui Wang

TNF has both proinflammatory and antiinflammatory effects. It binds to two structurally related but functionally distinct receptors TNFR1 and TNFR2. Unlike TNFR1 that is ubiquitously expressed, TNFR2 expression is more limited to myeloid and lymphoid cell lineages including a fraction of regulatory T cells (Treg). In general, TNFR1 is responsible for TNF-mediated cell apoptosis and death, and mostly induces proinflammatory reactions. However, TNFR2 mainly leads to functions related to cell survival and immune suppression. Treg play an indispensable role in maintaining immunological self-tolerance and restraining excessive immune reactions deleterious to the host. Impaired Treg-mediated immune regulation has been observed in various autoimmune diseases as well as in cancers. Therefore, Treg might provide an ideal therapeutic target for diseases where the immune balance is impaired and could benefit from the regulation of Treg properties. TNFR2 is highly expressed on Treg in mice and in humans, and TNFR2+ Treg reveal the most potent suppressive capacity. TNF-TNFR2 ligation benefits Treg proliferation, although the effect on Treg suppressive function remains controversial. Here, we will describe in detail the TNF-mediated regulation of Treg and the potential clinical applications in cancer immunotherapy as well as in autoimmune diseases, with the focus on human Treg subsets.

Part of the book: Cytokines

Xinhui Wang

Latest work with IntechOpen by Xinhui Wang

Advances in Candida albicans

Chapters authored

Related collaborators

Misbahul Arfin

Simona Popa

Abdulrahman Al-Asmari

Liliana Georgeta Foia

Xuehui He

Mubarak Muhammad

Matjaž Jeras

Ariana Barlič

Sara Žigon-Branc

Harumi Jyonouchi