Recently, there has been growing attention to nanofluids, especially in industry. More and more people nowadays see nanoparticle applications in various fields such as automotive, agriculture, medicine, machining, and so on. The addition of different nanoparticles to fluids has shown enormous advantages, particularly for improving the efficiency and therefore lowering the energy consumption of processes for addressing a wide range of global challenges related with energy and environmental problems. Nanoparticles are of great scientific interest as they are in that nanofluid with unusual effects, and ultra-small sizes will be a new area for researchers and definitely offer novel mechanisms and technologies in the future. In this chapter, the authors will mainly present the characteristics as well as latest advances in applications of nanofluids in machining practices. Nanoparticle additives contribute to reduce friction coefficient, lower the energy consumption, and significantly extend tool life by lowering thermal stress, from which the surface quality of manufactured parts improves. Moreover, the nanoparticle application in some of the green technologies as MQL and MQCL using vegetable oils not only brings out superior cooling and lubricating properties and minimizes the use of cutting fluids, but also creates new solutions for machining, especially for difficult-to-cut materials.