\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"285",leadTitle:null,fullTitle:"HIV-Host Interactions",title:"HIV-Host Interactions",subtitle:null,reviewType:"peer-reviewed",abstract:"HIV remains the major global health threat, and neither vaccine nor cure is available. Increasing our knowledge on HIV infection will help overcome the challenge of HIV/AIDS. This book covers several aspects of HIV-host interactions in vitro and in vivo. The first section covers the interaction between cellular components and HIV proteins, Integrase, Tat, and Nef. It also discusses the clinical relevance of HIV superinfection. The next two chapters focus on the role of innate immunity including dendritic cells and defensins in HIV infection followed by the section on the impact of host factors on HIV pathogenesis. The section of co-infection includes the impact of Human herpesvirus 6 and Trichomonas vaginalis on HIV infection. The final section focuses on generation of HIV molecular clones that can be used in macaques and the potential use of cotton rats for HIV studies.",isbn:null,printIsbn:"978-953-307-442-9",pdfIsbn:"978-953-51-6542-2",doi:"10.5772/808",price:139,priceEur:155,priceUsd:179,slug:"hiv-host-interactions",numberOfPages:378,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"866f644bfdb6124645182ecd5188c6c7",bookSignature:"Theresa L. Chang",publishedDate:"November 2nd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/285.jpg",numberOfDownloads:34595,numberOfWosCitations:25,numberOfCrossrefCitations:10,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:22,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:57,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 3rd 2010",dateEndSecondStepPublish:"December 1st 2010",dateEndThirdStepPublish:"April 7th 2011",dateEndFourthStepPublish:"May 7th 2011",dateEndFifthStepPublish:"July 6th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"34802",title:"Dr.",name:"Theresa Li-Yun",middleName:null,surname:"Chang",slug:"theresa-li-yun-chang",fullName:"Theresa Li-Yun Chang",profilePictureURL:"https://mts.intechopen.com/storage/users/34802/images/system/34802.jpg",biography:"Dr. Theresa L. Chang received her Ph.D. from New York University with Alice S. Huang and did her postdoctoral trainings with Joan A. Steitz and Xin-Yuan Fu at Yale University and with John P. Moore at Aaron Diamond AIDS Research Center, The Rockefeller University. She worked as a scientist at Osel, Inc before joining Mount Sinai School of Medicine as Assistant Professor in 2002. She joined Public Health Research Institute, University of Medicine & Dentistry of New Jersey - New Jersey Medical School in 2010 as Principal Investigator. Her current research focuses on the role of innate immunity in sexually transmitted infection-mediated enhancement of HIV transmission, and on HIV infection of human peritoneal macrophage.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"22784",title:"Molecular Crosstalk between HIV-1 Integration and Host Proteins – Implications for Therapeutics",doi:"10.5772/23095",slug:"molecular-crosstalk-between-hiv-1-integration-and-host-proteins-implications-for-therapeutics",totalDownloads:1820,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Youichi Suzuki, Yasutsugu Suzuki and Naoki Yamamoto",downloadPdfUrl:"/chapter/pdf-download/22784",previewPdfUrl:"/chapter/pdf-preview/22784",authors:[{id:"30581",title:"Dr.",name:"Youichi",surname:"Suzuki",slug:"youichi-suzuki",fullName:"Youichi Suzuki"},{id:"50563",title:"Prof.",name:"Naoki",surname:"Yamamoto",slug:"naoki-yamamoto",fullName:"Naoki Yamamoto"},{id:"54840",title:"Mr.",name:"Yasutsugu",surname:"Suzuki",slug:"yasutsugu-suzuki",fullName:"Yasutsugu Suzuki"}],corrections:null},{id:"22785",title:"HIV Infection «HIV Tat Protein, a Key Factor in Pathogenesis and Immune System Dysregulation: Implication of IL-10»",doi:"10.5772/23167",slug:"hiv-infection-hiv-tat-protein-a-key-factor-in-pathogenesis-and-immune-system-dysregulation-implicati",totalDownloads:1526,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Ben Haij N., Planès R., Mzoughi O. and Bahraoui E.",downloadPdfUrl:"/chapter/pdf-download/22785",previewPdfUrl:"/chapter/pdf-preview/22785",authors:[{id:"50889",title:"Prof.",name:"Bahraoui",surname:"Elmostafa",slug:"bahraoui-elmostafa",fullName:"Bahraoui Elmostafa"},{id:"80240",title:"Ms.",name:"Nawal",surname:"Ben Haij",slug:"nawal-ben-haij",fullName:"Nawal Ben Haij"},{id:"118078",title:"Ms.",name:"Mzoughi",surname:"Olfa",slug:"mzoughi-olfa",fullName:"Mzoughi Olfa"},{id:"118079",title:"Mr.",name:"Planes",surname:"Remi",slug:"planes-remi",fullName:"Planes Remi"}],corrections:null},{id:"22786",title:"HIV-1 Nef Transfer and Intracellular Signalling in Uninfected Cells",doi:"10.5772/21623",slug:"hiv-1-nef-transfer-and-intracellular-signalling-in-uninfected-cells",totalDownloads:2024,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Zulema A. 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The cheetah,
As an animal built for speed, all parts of its body have evolved for precision and agility. Because of its small, aerodynamic head, lean body, long legs, flexible backbone and tail that works like a boat’s rudder, the cheetah can change direction in a split second and reach speeds of up to 113 km/h while turning 180° [6, 7, 8]. With each stride, the cheetah covers 6 m with just one foot touching the ground at a time; at two points in the stride, all four feet are in the air. The cheetah’s flexible spine acts like a spring as it doubles up with feet under its body to clench the earth with powerful, semi-non-retractable claws, thrusting it forward with great speed and maximum distance. The cheetah is not only the fastest running land mammal; it is also known for its rapid acceleration, as it can go from zero to 96 km/h in just 3 s [6].
\nWith less than 7100 adults and adolescents remaining [9], the cheetah is one of the most endangered big cat species. Cheetah numbers have declined primarily due to increased human-wildlife conflict, loss of habitat and loss of prey, and the illegal wildlife trade. In addition to these threats, cheetahs lack genetic variation due to a historic population bottleneck, approximately 12,000 years ago, which makes the cheetah more vulnerable to ecological and environmental changes [10, 11, 12].
\nToday, nearly 80% of the remaining world’s cheetahs are found outside of protected areas living near rural livestock farming communities [9]. Protected areas, such as wildlife reserves or national parks typically have higher densities of larger or more aggressive predator species that can outcompete cheetahs, making it difficult for cheetahs to survive. Despite being one of the best hunter species on the savanna, cheetahs often lose their kills to larger predators. In protected areas, cheetahs have been found to lose 10–15% of their kills to lions (
Living outside protected areas prevents threats by other predators but puts the cheetah in direct conflict with commercial and subsistence livestock farmers [18, 19]. These farmers often perceive cheetahs to be a threat to their livestock, which leads into economic and emotional issues. The Rangewide Cheetah and Wild Dog program, an IUCN Cat Specialist endorsed program, brings together conservation organizations across the cheetah’s range to work on a more sustainable future for cheetahs and farmers. Cheetah Conservation Fund (CCF), Cheetah Conservation Botswana (CCB), and the Ruaha Carnivore Project work with other stakeholders, such as community members, local and national governments, conservancies and scientists to develop and implement action plans for cheetah conservation throughout its range [9, 20, 21, 22, 23].
\nAs human populations grow, so do the chances of conflict with cheetahs. Simultaneously, available rangeland will shrink, along with the wild prey base, hastening the decline of the cheetah [24, 25]. If the observed trends of decline among cheetah population continues, the world’s fastest land mammal could become extinct within the next 15–20 years [26].
\nThe cheetah was once one of the most widely distributed of all land animals. Through the course of time the cheetah was found from North America to China, throughout Asia, India, Europe, and Africa. About 20,000 years ago, it settled into its current range [3, 27].
\nA century ago, approximately 100,000 cheetahs were found in at least 44 countries throughout Africa and Asia. Today, the current free-ranging populations of cheetahs are restricted to 10% of their former range, found only in small, fragmented areas spread across 23 countries in Africa (in North Africa, the Sahel, East Africa and southern Africa), however, two thirds of these countries’ cheetah populations number less than 200 individuals [9, 28]. It is estimated that fewer 50 wild cheetahs remaining in Iran, the last of the Asiatic population [9, 29].
\nToday, viable populations may be found in less than half the countries where cheetahs still exist. Cheetahs are particularly difficult to census due to their large home ranges, which average more than 1500 km2 [14, 30, 31, 32], and their shy nature, an instinct that has been reinforced because of persecution on farmlands, where they are shot, trapped and chased [19, 22, 33, 34]. As a result of persecution and due to their naturally large home ranges, wherever they live they occur in low densities [34].
\nAll populations of cheetahs are listed on the Convention on International Trade in Endangered Species of Fauna and Flora (CITES) Appendix 1 and are classified as Vulnerable or Endangered by the International Union for Conservation of Nature (IUCN) [35]. All cheetah populations are threatened due to habitat reduction and declines in prey populations, which bring them into increased contact (and ultimately conflict) with farmers and livestock [14, 20, 21, 22, 23, 33].
\nDue to its declining numbers and genetic lack of diversity, it is important to protect remaining wild cheetah populations to ensure the species chances for survival. An evaluation of conservation priorities in each country where the cheetah is found has been conducted to better understand the issues involved in achieving this goal [20, 21, 22, 23, 33, 36]. The remaining strongholds for cheetahs are Namibia and Botswana, in southern Africa; and Kenya and Tanzania in East Africa (see Figure 1). With approximately 20% of the world’s remaining wild cheetahs and successful efforts to conserve its wild population, Namibia is popularly known as “The Cheetah Capital of the World.”
\nHistoric and current: cheetah range map [
As a result of habitat fragmentation over time, there are currently four genetically confirmed subspecies of cheetah, three African and one Asiatic subspecies [4, 12, 37]. These subspecies are physically distinct from one another, and research is still ongoing to determine the genetic uniqueness of each. One previously-accepted subspecies, the Northeastern African Cheetah,
Cheetahs have evolved for speed and are not built to fight other predators. Because of this, they are shy in nature and will often abandon their kills in the presence of more robust predators, such as lions, leopards and hyenas [14, 39]. To combat this, cheetahs are typically diurnal hunters, as opposed to other large predator species, such as lions, hyena, and leopards, which are nocturnal [39, 40]. Their lack of defense against these predators has led to 80% of the current cheetah range being on farmland habitat [28, 41].
\nFemale cheetahs live solitary lives and do not form coalitions. After a 93 to 95-day gestation, solitary female cheetahs give birth to two to six cubs, with 3.5 being the average litter [13, 28, 42]. Cubs stay in the den for the first 6 weeks, with females moving their cubs to different nest sites for protection [39, 43].
\nAt 6 weeks of age, the cubs leave the den and follow their mother. At first, cubs will stay hidden while their mother begins to stalk prey. While the cubs are on their own, they may chase after inappropriate prey animals, such as jackals or birds [13]. To teach them how to catch appropriate prey, their mother will capture and release prey for the cubs to play with to practice their hunting skills [13]. The cubs will begin to chase the prey and trip it before the mother eventually comes and kills it for them [43]. Cubs start initiating their own hunts at about 1 year of age but are not proficient until they are independent [13]. Cubs stay with their mother for about 18–22 months. Even after they become independent, it can take cubs up to 3.5 years to master hunting [13]. Female cubs establish their home ranges within their mother’s larger home range, so there is familiarity among female cheetahs that are related [44].
\nOnce the young males disperse they will not maintain a territory until they are 4–5 years of age [13, 18]. Male cheetahs remain with their other male siblings from birth, forming a coalition for life. This behavior increases hunting success and is a defense against predators. By sticking together, they can hold and defend a better territory, where wildlife prey is abundant [39]. This also increases the chances of a greater number of desirable females coming into the territory for breeding.
\nMembers of a coalition are very bonded to one another. If separated, they do a lot of vocalizations. Cheetahs have a variety of unusual vocalizations including a dog-like bark and a bird-like chirp for calling between each other [13, 39]. Other sounds they make include a bubble or “uhun” sound, a hiss, and a growl. They are also very affectionate to each other. They purr and lick each other’s faces. Male coalitions work together when hunting and are able to hunt larger prey together. Cheetah coalitions are very stable, and the bond of brotherhood is permanent.
\nCheetahs require vast expanses of land with prey and other resources [9, 45]. Research in Namibia shows that cheetahs have an average home range of 1500 km2 with individuals covering 20–40 km in a week, but live in low densities throughout their range [14, 39, 45, 46]. Most cheetahs live in open grasslands and savanna, which are arid environments [35]. Throughout the cheetahs range, cheetahs are known to use tall trees for greater visualization as well as territorial markings. In Namibia, these trees have been called “playtrees,” as cubs are often seen climbing into them, or “newspaper tree,” as male cheetahs use these trees for leaving their territorial scent marks, urine and feces [14, 47]. However, in many ecosystems throughout the cheetah ranges, bush encroachment, a form of desertification caused by overgrazing arid landscapes as well as the decline of many of the large mega-herbivores, has caused a problem for cheetah hunting ability as well as altering the mix of wildlife [47]. Bush encroachment results in the prolific growth of a native plant species,
Changes in the arid ecosystems in favor of human needs have also created problems, mainly from overgrazing of livestock leading to desertification, leaving limited grazing for wildlife. Further compounding this issue, forces of nature that are unpredictable and difficult to manage such as climate change, negatively affect agriculture and wildlife as rangelands become drier and vegetation is altered [50]. This also affects distribution and abundance of prey [14, 45]. And, as the human population grows, air and water become more polluted, habitat is lost to development, and the climate crisis deepens. Ultimately, the cheetah’s chances for survival depend greatly on the re-balancing of the ecosystem and the restoration of habitat so it will support sufficient natural prey [26].
\nLearning to hunt is the most critical survival skill that the cubs must develop [13]. At 1-year-old cubs are participating in hunts and the mother, while assuring enough kills for the family’s survival, will allow the cubs to join in. Cheetahs hunt in the early morning and early evening and capture their prey by stalking to within 10–30 yards or as far as 80 yards before beginning the chase [13]. During a hunt, cheetahs usually catch their prey after an average 200-yard sprint [13]. Although fast, their ability to accelerate at a high speed is most critical, and their maneuverability enabling them to turn rapidly is more important than their speed. Most hunts take place at a slower speed, as prey are dodging in efforts to flee [39]. Successful hunters need not only speed but stealth as well. They move slowly and remain low in the grass, staying downwind, sometimes hiding behind small mounds to obscure their approach, taking advantage of their coloring to camouflage their appearance and blend into their surroundings [13].
\nOnly 10% of cheetah chases are successful, and diet depends largely on where the cheetah lives [13]. Medium-sized and smaller prey, such as antelope and gazelles, hare and the young of larger antelope like wildebeest (
Threats from other predators is one of the main reasons why nearly 80% of wild cheetahs today are found outside of protected areas (like national parks or wildlife reserves) and living alongside human communities [9, 28, 39]. In protected areas, cheetahs often lose their kill to larger and more aggressive predators. Cheetahs tend to lose 10–15% of their kills to other predators [39]. Cheetahs are apex predators and the best hunters on the savanna, they feed many species with their kills’ thus increasing biodiversity of the ecosystem in which they live [14]. Without this balance, other species within the ecosystem will also be adversely affected, ultimately resulting in negative consequences for the human population.
\nConservation research shows that the greatest conservation problems are not biological but have more to do with humans. Climate change and human population growth compounds these threats to an already genetically compromised species [19, 25, 33, 35, 45, 50]. Human-wildlife conflict, habitat loss and illegal wildlife trade have become the biggest threats to long-term cheetah survival [9, 26, 51, 52].
\nThe majority of people who live alongside cheetahs are rural subsistence farmers whose livelihoods depend on the health and wellbeing of their livestock. These farmers have traditionally viewed cheetah as worthless vermin, a nuisance and a threat. Some governments have sanctioned herd protection programs that allow for cheetahs on farmlands to be trapped and removed or killed on sight [51]. Culling of cheetahs in Namibia during the 1980s resulted in losses of nearly 7000 cheetahs due to real and perceived conflict with livestock and game farmers [18, 53]. While these programs were popular during the 1970s and 1980s, this led to a rapid, widespread reduction in the numbers of wild cheetah, which fortunately has been stemmed by the intervention of conservationists and the introduction of non-lethal predator control techniques [19].
\nIn Northern Africa, the rarity of the Saharan or desert cheetah is directly linked to the rarity of the prey species, as the IUCN Red List lists both predator and prey as critically endangered species [28]. The Saharan cheetah can still be found in small numbers in Algeria (Ahaggar and Tassili N’Ajjer), Niger (Termit and Aïr), and possibly also in Mali, Chad and Mauritania [9, 28]. Due to the decline of prey, mainly from poaching and overhunting, these cheetahs are living primarily on hare (
Habitat destruction across Africa and Iran is one of the biggest problems threatening cheetah survival. As wild lands are being destroyed and fragmented by human expansion, landscapes across Africa that once supported thousands of cheetahs now support only a few. With habitat loss comes the decline in wild game species that provide prey for the cheetah [45]. As the human population continues to grow exponentially, there is an every-increasing demand for land rights. This affects the cheetah, as increased agricultural pressure and subdivision of land mean a decrease in available habitat for the cheetah and other wildlife species [25].
\nFor many African wildlife species, living within a protected national park or private game reserve such as the Maasai Mara in Kenya, the Serengeti National Park in Tanzania, or Kruger National Park in South Africa is the difference between life and death. Animals that live on protected lands are guarded by rangers and photographed by tourists, which makes them less likely to be poached. But for some species, including the cheetah, living in protected areas results in greater competition with other larger and more aggressive predators that will steal their kills and kill their cubs. There is a high cub mortality (up to 90% in protected areas), mainly due to predation [15]. Consequently, nearly 80% of all cheetahs throughout their range are found living outside of protected parks and reserves [9, 28].
\nThe lifespan of an adult cheetah is between 8 and 10 years [18, 42]. Adult mortality is one of the most significant limiting factors for cheetah population growth and survival [18, 54, 55].
\nBecause of in-depth,
Genetic homogeneity can make a species more susceptible to ecological and environmental changes to which the world is subjected now and has been interpreted in the context of two potential risks: the expression of recessive deleterious alleles and increased vulnerability to viral and parasitic epizootics that can affect genetically uniform populations [11, 12]. Cheetahs are known to be very susceptible to several feline diseases and are possibly more vulnerable due to the lack of heterogeneity in the population [11, 56, 57]. As cheetahs transverse the farmlands where more villages occur, the potential for disease transmission increases. Given the species lack of genetic diversity, monitoring the overall health of cheetah populations is an important component of understanding and promoting its long-term viability.
\nAnother major threat is the trafficking of live cheetahs for the illegal pet trade. Wildlife trafficking is one of the top five transnational crimes and it is impacting affecting the survival of many species (U.N. Office on Drugs and Crime). While cheetahs are not poached at the same high rates as elephants and rhinoceros in Africa, an estimated 300 cheetah cubs are being smuggled out of the continent each year to supply the illegal pet trade [52] (Figure 2). Illegal capture is occurring mostly in Ethiopia, Somalia and northern Kenya, with most cases being reported in Somaliland [52]. Although trade in wildlife species products is regulated by both international and national laws, the illegal wildlife trade is estimated to be worth between $50–150 billion USD annually. Cheetahs, listed as an Appendix 1 species under CITES, are removed from the wild for the pet trade and for their body parts.
\nA caged cheetah cub confiscated from illegal wildlife trafficking. Cheetahs are often illegally sold as pets to the Middle East and for everyone that makes it live into the trade, 5 die in transport.
Because the cheetah is light and built for speed and has a flight versus fight instinct. For this reason, the cheetah is a sought-after pet in multiple regions of the world [52]. In the Gulf States, cheetahs are one of the most popular exotic pets and are a status symbol [52]. Photos posted on social media show cheetahs with gem-studded collars posing in luxury vehicles beside their owners, or riding in speedboats, or in other outlandish depictions.
\nKeeping a wild cheetah as an exotic pet undermines the species, as its numbers are so low it cannot sustain regular losses and still hope to survive. The illegal pet trade is decimating cheetah populations that are already small and nearly unsustainable [9, 52]. Five out of six cubs poached die before being sold into the pet trade. Cheetah cubs that survive long enough to be sold most likely will not make it beyond 2 years of age. All will become sick, disabled and die prematurely. Improper diet, environment and lack of veterinary care result in a myriad of debilitating health problems [52].
\nAnother human issue impacting the cheetah is tourism. Everyone who visits Africa on safari wants to see a cheetah. While tourism helps bring international attention to the cheetah and instills economic value in species survival, crowds of multiple vehicles surrounding cheetahs can have a negative impact [20, 58, 59]. Cheetahs hunt in the early morning and late afternoon when most game drives take place. Vehicles sometimes move between the cheetah and its prey so tourists can get a better view. This interferes with the cheetah’s ability to catch its prey and can separate mothers from cubs [20, 58, 59].
\nPredators are exceptionally aware of tourists and their vehicles and sometimes use them to their advantage. If a cheetah has made a kill it will most certainly lose it if vehicles are present, since other predators, particularly the hyena, lion or jackal are alerted by the tourists. If the cheetah has cubs, this is a very dangerous situation for them, as they are made more vulnerable by the interference of the vehicles. Research conducted in the Maasai Mara recorded that nearly 30% of cheetah sightings had more than 20 vehicles surrounding it, and of these, more than 50% were less than 30 yards from the animal [58]. Nearly 60% were reported as being noisy (hooting and engine revving) with tourists and drivers shouting or talking very loudly [20]. The busiest time for the tourist vehicles was found to be between 4:40 and 6:30 pm coinciding with the high times for hunting by cheetahs [20].
\nIn the Maasai Mara, a high incidence in sarcoptic mange in cheetahs has been linked to stress caused by tourism vehicles. Chronic stress induces immuno-suppression, which in cheetahs has been found to contribute to a high occurrence of uncommon diseases, like mange, gastritis and amyloidosis [56, 57, 58, 61].
\nSolving cheetah conservation crisis involves addressing a complex web of social, environmental and economic issues. Although people are the root of most of the problems facing the cheetah in today’s world, they are also the solution as well. Over the past several years, conservation professionals have come together to look closely at the crisis for the cheetah and devise strategies for cheetah survival [9, 24].
\nThough the situation for the wild cheetah is dire with less than 7100 wild adult and adolescents remaining, there is hope for species’ long-term survival. Efforts to educate communities living alongside cheetah through awareness building media campaigns and to obtain government buy-in have been successful [60]. Range-wide strategies for the cheetah have been developed and implementation is underway through eastern, southern, north, west and central Africa [9, 14, 36]. Capacity building for range country conservation scientist and agriculture extension officers is an ongoing process, using the “train the trainer” approach [26, 60]. Committed conservationists are focusing on the bigger picture, encouraging community participation in finding solutions that alleviate conflict. The bigger picture allows for a global perspective and a multi-species, integrated approach to cheetah conservation.
\nAt the 2003 World Park’s Conference, conservation practitioners agreed there was need for community ownership and responsibility over assessing and addressing human wildlife conflict (HWC). To be successful, improved communication on a local level between stakeholders and on a global level between experts, practitioners, local communities and international conservation organizations would be required. Guidance manuals, processes and systems needed to be developed, and HWC mitigation needed to be supported by international political and legal institutions.
\nIn 2007 and again in 2012, government representatives, non-government organizations (NGOs) and the International Union for Conservation of Nature (IUCN) Species Survival Commission’s (SSC) Cat Specialist Group met to develop regional strategies for the survival of cheetahs [20, 21, 22]. Since then, strategies for the three regions of Africa have been developed: central, west, and southern, eastern and north. The Range Wide Conservation Plan is a joint initiative of the Wildlife Conservation Society and the Zoological Society of London, in partnership with the Cat and Canid Specialist Groups of the IUCN/SSC. These strategies have created a structure under which government programs could be developed, thus enabling conservation action on a national level. Subsequently, National Action Plans have been developed in 13 cheetah range countries [14, 20, 21, 22, 23].
\nToday, cheetah research and conservation programs are found in Botswana, Iran, Kenya, Namibia, Tanzania, South Africa, and Zimbabwe [14]. Furthermore, cheetah research and training has been conducted in countries such as Algeria, Angola, Benin, Ethiopia, Mozambique, Niger, Zambia and Somaliland [26].
\nCommunity-based, natural resource management NGOs are also working with many communities throughout Africa to develop integrated programs incorporating tourism development and economic incentives to diversify livelihoods for its citizens [62]. Through outreach programs focusing on agricultural education, farmers are being taught about livestock health and management along with grasslands, wildlife and basic principles of ecology [19, 60]. Conservancies—collaborative partnerships of neighboring farms united by common operating principles—are being formed to implement standardized land management techniques that benefit people, livestock and wildlife [33, 49, 63, 64]. Examples of successful conservancies are being used to provide the basis for developing large-scale trans-boundary land management plans for the future [64].
\nConservation biologists increasingly underscore that national parks and reserves alone are not large enough to sustain the wildlife they were created to protect. This is particularly true for the cheetah [25, 65]. Therefore, the focus on conservation of private land is crucial. Conservancies are one of the most important solutions for cheetah survival as they promote sustainable management of natural resources and development of responsible eco-tourism [64]. Conservancies give communities a vested interest in the welfare of local wildlife by giving them control over the economic benefits from wildlife populations. As a result, fewer problems with poaching are experienced and human-wildlife conflict is reduced [49].
\nWith populations dwindling through most cheetah-range countries, cheetah survival depends on people using an informed, integrated approach to conservation. Education is the foundation and must include communication, information sharing and capacity building [60, 66]. In 2005, CCF began conducting month-long courses to bring together conservation managers, scientists, and community representatives from African cheetah-range countries and Iran [66]. The courses build capacity, with a goal of stabilizing cheetah populations. More than 300 participants are now managing cheetah and wildlife conservation programs in their own countries.
\nAt the same time, research into ways to conserve and restore habitat for cheetahs and farmers is also important by working with local livestock farming communities, to help improve their livelihoods. Assigning economic value to cheetahs and having a thriving population on the landscape is key. Training programs have been developed by the Cheetah Conservation Fund that address human-wildlife conflict called Future Farmers of Africa (FFA) [66]. FFA teaches best agricultural practices to rural farmers to help them manage integrated wildlife and livestock farmlands. FFA also teaches how non-lethal predator control methods can reduce predation losses. The use of livestock guarding dogs is included in this course. CCF has helped develop similar programs throughout the cheetah’s range. Many of these methods of reducing predator conflict are also applicable or adaptable to other animals such as mountain lions, jaguars and wolves, and have been used as models elsewhere in the world.
\nFFA covers topics like livestock health, veterinary care, husbandry, and valuation as well as wildlife and rangeland management, methods of non-lethal predator control, predator identification and best practices to reduce livestock losses including the use of kraals, birthing camps as well as seasonal, coordinated breeding. The use of a livestock guarding dog has been shown to be a very effective tool and is included in training [67] (see Figure 3). The Anatolian shepherd or Kangal dogs have been used for thousands of years in the Turkish region of Anatolia as livestock guarding dogs, where they were formidable guardians of livestock against bears and wolves [69, 70, 71].
\nA goat herd protected by a livestock guardian dog in Namibia. Turkish Anatolian shepherd and Kangal dogs are bred and placed with livestock through the Cheetah Conservation Fund in Namibia.
Since 1994, the Cheetah Conservation Fund (CCF) in Namibia, has bred and placed these dogs with livestock farmers to reduce conflict with livestock and reduce the killing of cheetahs and other predators. Farmers who use CCF LGDs report a decrease in predation rates ranging over 80% [70, 72]. Simultaneously, LGDs reduce the killing and capture of cheetahs and other predators [72, 73]. The dogs have been so successful, similar programs in South Africa, Botswana and in Tanzania [68].
\nIncreasingly, today’s consumers rely on product labels to guide their purchases, and at the same time, are willing to pay a premium price to ensure a product’s providence. In 2000, CCF conceptualized the Cheetah Country—Eco-Labeling Program to encourage predator-friendly farming techniques in producing beef, goat cheese, crafts, honey and wine [49, 62]. Under the brand
The outlook for the cheetah is today in human’s hands. Cheetah populations can rebound. But humans also have the capacity to save them. In many parts of Africa, cheetahs and other large predators are viewed as threats to human livelihoods, rather than species vital to maintaining healthy, balanced ecosystems. Good livestock management can protect herds while allowing prey and room for cheetahs and other predators. Having thriving cheetah populations also brings economic value to land as they and other predator species help drive tourism.
\nImplementation of more programs now is critical, so future generations will benefit from having cheetahs on earth. Continuing to expand our scientific research will be important (Figure 4), while collaborating with international institutions in fields such as cheetah health, genetics, reproduction, ecology to establish population numbers, as well as expanding training and capacity building programs will be key in cheetah conservation, while expanding efforts to stop the illegal cheetah trafficking. If we wait much longer, we will lose this amazing feline icon of speed and grace. A holistic approach that considers all stakeholders is critical to balance the needs of people, wildlife and the land and try to make their efforts sustainable. This way, the communities are more likely to be good stewards of wildlife. The end goal to save the cheetah is to achieve coexistence. This is the only way to ensure a permanent place for cheetahs on Earth.
\nSatellite collars allow monitoring of cheetahs movements. Through understand the cheetah’s use of their large home ranges (ave. 1500 km2) allows for management plans can be used with rural communities to plan for the cheetahs’ survival in the future.
Education and outreach are key in building awareness for the cheetah’s plight and for developing sustainable practices that alleviate pressure on the species. Looking to the future, teaching conservation and instilling a high regard for the environment among young learners will help cheetahs secure a permanent place on Earth.
\nCreative approaches are also necessary. The future of the cheetah will require enhancing the livelihoods of the human communities that live alongside them. These include developing alternative income sources, such as eco-tourism, economic incentives for predator-friendly products. The concept is that farmers in cheetah range areas can be monitored and certified as practicing predator-friendly livestock management. In return for being good stewards to the cheetahs on their land, these farmers can be certified with the Cheetah Country eco-label and receive premium prices for their products [49, 62]. A program in development, its model could serve to protect all of the world’s predators, each of whom are threatened by conflict with humans and yet are vital to maintaining the health and biodiversity of their ecosystem.
\nDespite all of the problems facing the cheetah, including genetic uniformity, competition with other large predators, destruction of habitat and conflict with humans, this iconic animal has survived for thousands of years. Cheetahs continue to fulfill their ecological role as the fastest mammalian apex predator on land. With integrated conservation programs across large landscapes, survival of cheetahs for future generations can be attained [26].
\nThanks to the Cheetah Conservation Fund for their support of long-term research (www.cheetah.org), Susan Yannetti and Natalie Minor for their assistance with editing of this Chapter.
\nPatients with diabetic neuropathy develop foot problems, some of which can improve with surgery. Tendon balancing is one of the procedures used to treat diabetic foot problems. Tendon lengthening, such as gastrocnemius-soleus recession (GSR), has fewer complications than bony procedures in the foot [1, 2, 3, 4, 5, 6].
Tendon lengthening should be performed before bony procedures in high-risk patients such as diabetics, patients with foot ulcers, infection, smokers and without pedal pulses [1, 2, 3, 4, 5, 6]. Imbalance of tendons, especially Achilles tightness, can aggravated or cause or many foot problems [1, 2, 3, 4, 5, 6, 7]. Tendon lengthening can be used as part of treatment for many foot problems [2, 7, 8, 9, 10, 11, 12].
A large number of patients have diabetes and the number is increasing [13]. Foot ulcers are common in patients with diabetes mellitus [14, 15]. Foot ulcers can lead to infection and amputation. Amputation can result from infection from foot ulcers [15, 16]. Over 80% of amputations in diabetic patients have foot ulcers [15, 16].
The most common chronic wounds in industrialized countries are foot ulcers [17, 18]. The average excess cost of a foot ulcer over a two-year period is over $25,000 [19].
The most common reason for diabetic patient to be admitted to the hospital is foot infection [20]. Up to 50% (62/133) amputation and 20% (26/133) major amputation can occur in patients admitted for foot ulcer or foot infection [16]. Over 80,000 amputations have occurred in diabetic patients in the U.S in one year [21]. If foot ulcers could be cured, most amputations in diabetics could potentially be prevented [15, 16].
The most common cause of neuropathy is diabetes mellitus [22, 23]. Neuropathy causes decreased protective sensation and motor neuropathy causes tendon tightness [24, 25, 26]. Tightness of tendon, especially the Achilles, causes increased forces in the foot [27]. Increased forces in the forefoot can cause a callus followed by a forefoot ulcer [14, 27]. Increased forces in the foot can also cause Charcot foot, including foot arthritis, arch collapse, midfoot bony prominence and then midfoot ulcer [10, 28]. Foot ulcers can also result from other causes of neuropathy besides diabetes and can be treated in the same way [24, 26, 29].
Foot ulcers are of managed by addressing infection, arterial disease and high forces in the foot. Infection is treated with antibiotics and debridement. Which antibiotic is determined by deep culture and, if needed, infectious disease consultation [30]. Vascular evaluation and treatment is recommended if the patient lacks both pedal pulses. Hyperbaric oxygen may a decrease the frequency of major amputations, but more studies are needed to confirm its causation in the decrease [31].
Off-loading consists of decreasing force in the foot. Forces in the foot can be decreased by tendon lengthening [27]. More ulcers than wound care and total contact casting (TCC) are healed by tendon lengthening [2, 24, 25, 26, 29, 32, 33, 34, 35, 36, 37, 38, 39]. Tendon lengthening treatment of foot ulcers has good literature support [2, 24, 25, 26, 27, 29, 33, 34, 35, 36, 37, 38, 39, 40, 41].
TCC, walking boots, and modified shoes helps heal foot ulcers [14]. However, TCC are difficult to apply, and has a higher complication rate and higher rate of recurrent ulceration than does tendon lengthening [32, 33]. Tendon lengthening removal of prominent metatarsal heads have similar results similar but with more transfer ulcers when only metatarsal head is removed [3].
Multiple authors reported the association of gastrocnemius-soleus contracture, neuropathy, and chronic ulceration of the forefoot [24, 25, 26]. The high rate of successful healing of forefoot ulcers after Achilles lengthening was reported in multiple studies [24, 25, 26, 33, 34, 35, 36, 41]. Also a high rate of healing of midfoot and toe ulcers also occurred after tendon lengthening [2, 29].
The recurrence rate of foot ulcers after three years in diabetic patients treated without tendon lengthening, was 61% (286/468) [42]. After Achilles tendon lengthening, forefoot ulcer recurrence rates were much lower, 14% [41]. There is also a low rate of recurrence of toe ulcers treated with toe flexor tenotomy and with midfoot ulcers treated with tendon lengthening [2, 29].
Mueller et al. reported recurrence 10 of 26 ulcers 2 years after Achilles lengthening [33]. Adding peroneus longus and posterior tibial to gastrocnemius–soleus recession (GSR) yielded less recurrence, 3 of 18 at 45 months follow-up [26]. Dayer and Assal also had a low recurrence (1/22) by adding tendon procedures such as peroneus longus transfer to gastrocnemius recession [36].
The intention of tendon lengthening is to decrease force on the area of ulceration. The pressure on the first metatarsal head should decrease with peroneus longus lengthening as the pressure on the fifth metatarsal should be decreased with posterior tibial lengthening. Force on the entire plantar forefoot should decrease with GSR. Armstrong et al. demonstrated that Achilles lengthening does in fact decrease pressure on the forefoot and recommended this procedure to help treat and prevent foot ulceration [27].
Multiple authors lengthened the Achilles tendon by Hoke’s method of hemisection at 3 levels of the tendon [25, 33, 35]. Holstein warned that Hoke’s procedure for diabetic forefoot ulcers caused 7/75 Achilles ruptures and 11/75 heel ulcers in his patients [35]. Achilles tenectomy for distal ulcers after transmetatarsal amputation had 4/32 (13%) plantar heel ulcers [34]. Subcutaneous tenotomy method of Strohmeyer was used by Yospovitch and Sheskin [24, 43]. Vulpius technique of GSR is used by this author [44]. A very low rate of heel ulcers and other complications of GSR has been reported [2, 26, 36, 41].
Takahashi and Shrestha used the Vulpius procedure successfully to correct Achilles tightness in 230 adults after cerebrovascular accident [1]. Ninety-eight were diabetics and the average age was 68 and had no tendon or incision problems.
The results appear to be good whatever technique of lengthening of the gastrocnemius-soleus or Achilles tendon, [41]. Choice of the surgeon can determine the technique of Achilles lengthening for forefoot ulcers.
Tendon lengthening literature shows better results than other treatments for forefoot and midfoot ulcers [41]. Tendon lengthening should be used more often to treat of diabetic ulcers forefoot and midfoot ulcers [2, 24, 25, 26, 29, 33, 34, 35, 36, 37, 40, 41].
TCC resulted in healing in 90% (64/71) of foot ulcers [45]. However ulcer recurrence at 18 months follow-up occurred in 34% (22/64). A high complication rate of 31% (22/70) has also been reported with TCC [32]. A comparison of healed ulcers at two year follow-up revealed 81% (21/26) recurred after TCC but only 38% (10/ 27) recurred after Achilles lengthening was added in the only controlled randomized study available [33].
TCC is apparently not needed for forefoot ulcer healing, since TCC was not used in most more recent studies after Mueller’s article [26, 29, 33, 35, 41]. Wound care healed only 31% (142/458) of diabetic foot ulcers in 5 months in a meta-analysis of the literature [38]. An average of 80% of diabetic foot ulcers healed with TCC [39]. Tendon lengthening has better healing rate for ulcers than wound care and TCC [2, 24, 25, 26, 29, 33, 34, 35, 36, 38, 39, 40, 41].
Tendon lengthening also has less complications and a much lower recurrence rate than TCC [2, 24, 25, 26, 29, 32, 33, 34, 35, 36, 41]. This author agrees with other authors that tendon lengthening rather than TCC should be considered the “gold standard” treatment for forefoot ulcers [26, 36, 41].
Foot surgeons have recommended metatarsal head resection to heal ulcers plantar to metatarsal heads. Even though this procedure frequently resulted in ulcer healing, transfer metatarsal ulcer frequently occurred later. Transfer ulcers occurred in 52% (53/101) of patients in the 35 months of follow-up after metatarsal head resection [3]. Repeated transfer ulcer and metatarsal head removal can result in gradual resection of the forefoot, then amputation stump ulcer and possible major amputation [42].
Tendon lengthening can be used instead of metatarsal head resection to decrease the potential for transfer ulcers resulting from the increased pressure on the forefoot. The metatarsal head should be removed if bone infection is severe enough to cause bone fragmentation or necrotic tissue. The metatarsal head can be removed if osteomyelitis persists after the ulcer healing and antibiotics completion [26].
A high rate, 95% (21/22), of successful healing of neuropathic forefoot ulcers occurred after dorsiflexion metatarsal osteotomy [4]. However, a 68% complication rate occurred with seven patients developing acute Charcot disease, three developing midfoot ulcers, three deep wound infections, two transfer ulcers under adjacent metatarsal heads, and one transtibial amputation. Fewer complications occurred after tendon lengthening for forefoot ulcers resulted with no new or worsening Charcot arthritis or foot arthritis, new mid-foot ulcers, transfer metatarsal ulcers or wound infections [26]. After tendon lengthening complication rate is less than after metatarsal osteotomy and similar to non-operative treatment [4, 16, 26].
Amputation becomes necessary when infection and gangrene progress. In one study of amputations in diabetic patients, 84% (67/80) were attributed to foot ulcers [16]. In diabetics with forefoot ulcers, ray amputation resulted in transfer ulcers occurred in 12% (11/89) and additional amputation in 18% (16/89) [46]. Transmetatarsal amputation has used to treat chronic diabetic forefoot ulcers [47]. This resulted in wound breakdown in 9% (8/85), transtibial amputation in 26% (17/65) and 30% (17/57) death. Tendon lengthening complication rates lower than above have been reported with for forefoot ulcers [26, 41]. To increase healing rate to 81%, Pinzur et al. recommended Achilles lengthening be done at same time as transmetatarsal amputation (52/64) [48]. Achilles tenotomy was recommended by Lieberman et al. with midfoot (Chopart) amputation for gangrene and/or infection [49]. For forefoot ulcers, tendon lengthening seems to be better than amputation. Also combining Achilles lengthening with ray or transmetatarsal amputation for forefoot gangrene and/or severe infection appears preferable. By putting glove over infected foot, doing tendon lengthening first, applying dressing to leg, removing glove and then preforming partial foot amputation, tendon lengthening can be done at time of amputation without infection of proximal incisions.
The reported amputation rate was 16% (80/514) and 17% (78/468) during three years after healing of foot ulcers, [23, 42]. No patients (0/16) required amputation for progressive infection at average follow-up of 45 months in one study of tendon lengthening for forefoot ulcers [26]. More proximal major amputation may become necessary when all other treatments fail.
Gangrene in diabetics is primarily vascular problem. Arterial disease can aggravate most other diabetic foot problems. Vascular evaluation is recommended in patients without pedal pulses. Patients with palpable dorsalis pedis or posterior tibial arteries require no additional studies. Arterial Doppler is recommend for patients without both of those pedal pulses. Ankle-brachial index (ABI) has been used by others for lower extremity arterial evaluation. The ABI is calculated by dividing systolic pressure at the ankle by that at the arm. An abnormal ABI is 0.90 or below [50]. Vascular surgery evaluation should be obtained If the Doppler study shows near or complete blockage or if ABI is abnormal.
Vascular disease has been considered to be a contraindication to TCC [45]. Foot ulcers in patients without both pedal pulses can be salvageable with tendon lengthening [26, 29, 34].
Patients with foot ulcers can be considered for tendon lengthening after vascular and infection have been treated. Diabetes mellitus and vascular disease are the most common co-morbidities with neuropathic foot problems [26, 29]. These patients frequently have complications. Tendon lengthening has less complications than bony procedures [1, 2, 3, 4, 5, 6, 26, 29, 41]. Soft tissue procedures are usually performed first since they have lower complication rates, and then if they fail, bony procedures are done later.
Level I and level III studies have only been done for metatarsal head ulcers [25, 33, 36]. JBJS instructions for authors explains levels of evidence. There are however many level IV studies demonstrating effectiveness of tendon lengthening for foot ulcers [24, 26, 29, 34, 35, 41]. Level IV studies have advantages that the study populations are more likely to be representative of the population of interest, results are closer to those obtained in clinical practice, have a higher relevance and external validity and can be better applied to clinical practice [51]. Tendon lengthenings as the treatment of choice for diabetic forefoot ulcers seems to be supported by the above studies.
If infection is present, patients with ulcers are treated with antibiotics then debridement and tendon lengthening [26]. The foot is covered with a sterile glove after the patient’s skin is prepped in the operating room. Calf and ankle level tendon lengthening is done first and dressing applied. Glove is then removed for debridement of the foot and lengthening of toe tendons if needed. If gangrene of forefoot is present, debridement of gangrenous tissue and GSR are done to decrease pressure on the forefoot and to aid wound healing [41, 46, 48]. Vascular evaluation and wound care are also suggested. If forefoot wound healing is delayed after only debridement, transmetatarsal amputation [34], or Charcot arthropathy with or without ulcer [2], they are offered GSR. If gangrene of midfoot and/or hindfoot is present, transtibial or transfemoral amputation is suggested. Achilles lengthening to prevent ulcers is recommended for progressive metatarsal calluses [27].
GSR is used to treat all patients with ulcers plantar to metatarsal heads [24, 25, 26, 33, 35, 41]. With the patient supine the surgery is performed, while the knee is flexed and externally rotated. A stack of towels is placed under foot with the surgeon is seated on the opposite side. Vulpius technique [1, 26] is used, transecting the gastrocnemius tendon and underlying aponeurosis of the soleus just distal to the gastrocnemius muscle [44]. Ankle is dorsiflexed to 20–30°. Staples are used to close midcalf posterior longitudinal incision 5 cm. long after 3–0 absorbable suture closes the subcuticular layer. For recurrent ulcers and if patient can only tolerate local anesthesia percutaneous triple cut Achilles tenotomy can be used.
For first metatarsal ulcers peroneus longus (Z-type) lengthening is combined with GSR [26]. Incision is proximal to the ankle joint. The tendon repair is done with a 2–0 absorbable suture with no tension, with the first metatarsal is in maximum dorsiflexion and the foot is in maximum inversion. For fifth metatarsal ulcers posterior tibial lengthening is also performed [26]. Z-type lengthening is also performed through medial incision 5–10 cm. proximal to the ankle joint. Same technique is used to close these incisions. Repeat GSR or triple cut Achilles lengthening and percutaneous metatarsal osteotomy for recurrent metatarsal ulcers.
Full weight bearing is allowed immediately in a walking boot, which is worn for four to six weeks. Crutches or a walker is offered to the patient if needed for balance when surgery is bilateral. Ulcer treatment is clean dressings changed weekly. Skin staples are removed at two weeks. Diabetic-type shoes are recommended after six weeks. Double heel lift exercises are begun at 2 months and at 3 months single heel lift exercises. They can resume standing all day at work at 3 months. Running, jumping and climbing are allowed at 6 months.
Percutaneous toe flexor tenotomy at the proximal portion of the proximal phalanx is used for plantar toe ulcers [29, 52]. This can be done in the office, but can be done in the operating room if the patient is there for some other reason. Alcohol is used to prepare the toe, and then local anesthetic is given. Toe is extended so the tendons are palpable. Through a small (2 mm) transverse incision, both flexor tendons are transected. A sudden increase in extension of the distal and proximal interphalangeal joints of the lesser toes confirms division of both flexor tendons. After the flexor hallucis longus (FHL) is divided a sudden increase in extension of the interphalangeal joint of the hallux occurs. Suture is not used unless bleeding is excessive but incision is covered with sterile gauze. A postoperative shoe, sandal or extra-depth shoe can be used. Patients are allowed full weight-bearing. Patients return weekly until the ulcer heals.
Percutaneous extensor and flexor tenotomy can be used for a dorsal ulcer of PIP joint. Percutaneous capsulotomy dorsal metatarsal-phalangeal (MP) and volar (PIP) are also performed if needed. Percutaneous phalangeal osteotomy is performed if correction is insufficient.
For interdigital ulcers of the first web space, patients are offered percutaneous adductor tenotomy, and lateral capsule release of the first MP joint. An interdigital ulcer of the lessor toes may also have percutaneous MP capsular release in the lessor toe in addition to first toe surgery. Percutaneous phalangeal osteotomy or removal of prominent bone is performed if ulcer persists or recurs. Toe amputation is usually performed for osteomyelitis in the toe which is not controlled with antibiotics.
Midfoot ulcers can develop plantar to the bony prominence in the area of arch collapse from Charcot neuropathic arthropathy (Charcot foot). Exostectomy or fusion have recommended to be combined with Achilles lengthening [53, 54, 55, 56]. Good preliminary results have been found with tendon lengthening (GSR) alone as the initial treatment for midfoot ulcers: 9/10 ulcers healed, 1/9 recurred with less complications than bony procedures [2, 5, 6]. Tendon lengthening (GSR) seems to heal these ulcers, prevent progression of bony deformity and promote consolidation of fragmented midfoot bone [2, 57]. The lack of progression of deformity and low recurrence rate of GSR also compare favorably with the 41/140 (36%) deformity progression and 43/140 (37%) ulceration after non-operative treatment [56, 57].
Removal of plantar bony prominence percutaneously with a burr is now routinely added to GSR. Posterior tibial lengthening can be added for lateral midfoot ulcers and peroneal tendon lengthening for medial midfoot ulcers. GSR results in much fewer heel ulcers than does Achilles tendon lengthening [1, 41, 58, 59]. If the ulcer fails to heal or recurs, then tendon lengthening and percutaneous removal of the midfoot bony prominence (exostectomy) can be repeated [5, 41]. If the ulcer fails to heal or recurs, if there is no bony prominence and the foot is unstable, then midfoot fusion can be performed [6]. Soft tissue surgery is advantageous because diabetic patients have a higher complication rate with foot and ankle surgery [60].
Lengthening the Achilles in Charcot arthropathy was recommended by Thomas and Huffman [55]. Tendon lengthening is recommended for early stage Charcot foot to relieve pain, promote consolidation, prevent progression of deformity and heal or prevent midfoot ulceration from arch collapse [2, 57]. Bony procedures are less commonly done if tendon lengthening fails. Amputation is kept as a last resort.
A 47% decrease in major amputations in Medicare patients with diabetic foot ulcers between 2000 and 2010 has been reported [61]. In the same period Achilles tendon lengthening increased 89% and gastrocnemius recession increased 575%. The authors felt the main cause of decrease in major amputations was the increase in tendon lengthening. Recently performed a literature review on diabetic foot ulcer treatment and gave the highest recommendation (supported by strong evidence) to tendon lengthening [62].
Available evidence seems to indicate that tendon lengthening is the most effective treatment for plantar diabetic foot ulcers with the least complications [41, 57]. Tendon lengthening can also relieve foot pain, prevent ulcers and Charcot foot, and stop progression of Charcot arch collapse to rocker bottom foot, midfoot ulceration and amputation [57, 63]. Tendon lengthening may be combined with other modalities but should be done as soon as possible to promote rapid healing before the ulcer gets infected and to better prevent new, recurrent and transfer ulcers, progression of deformity and amputation [41, 57].
Yammine and Assi noted underuse of tendon lengthening which offered excellent outcomes with more ulcers healed faster with less recurrence, transfer ulcers, infection and amputation than nonsurgical treatment [64, 65]. This author recommends tendon lengthening as part of initial treatment for diabetic plantar forefoot and midfoot ulcers and Charcot of the midfoot [41, 57].
Diabetic patients without ulcers tend to have less neuropathy. They frequently develop painful foot problems including Achilles tendinitis, plantar fasciitis, foot arthritis and metatarsalgia.
McGlamery and Kitting stated that tight Achilles is the underlying cause of most foot problems and that permanent correction is only achieved by correction of Achilles tightness [7]. Achilles tightness is common in patients with Charcot foot, plantar fasciitis, Achilles tendinitis, metatarsalgia, foot arthritis, Morton’s neuroma and hallux valgus [66, 67].
Gastrocnemius recession (GR) has been recommended for the treatment of these problems in patients without neuropathy or diabetes [8, 9, 10, 11, 12, 68]. Anderson et al. felt that gastrocnemius tightness causes metatarsalgia, plantar fasciitis, Achilles tendinitis and arch pain [10, 68]. Achilles tightness, can cause progressive arch collapse, foot arthritis and flat foot which can progress to posterior tibial tendon dysfunction and heel valgus. High (94%, 32/34) patient satisfaction has been reported using GSR for plantar fasciitis. Anderson felt GR not only helped the pain of these conditions but prevents the progression described above [10, 68]. Several authors recommend GR for pain relief in patients with arch collapse, foot and ankle arthritis, Achilles tendinitis, plantar fasciitis, posterior tibial tendinitis [8, 9, 10, 11, 12, 68]. GR may be useful in preventing these problems and foot ulcers so is especially useful in diabetic patients [10, 27].
Painful hammer, mallet or claw toes, especially with progressive toe callus, are offered toe flexor tenotomy after failure of non-operative treatment. These procedures are also done both for pain relief and to help prevent future ulcers in diabetic patients. Percutaneous capsulotomy and/or percutaneous phalangeal osteotomy are performed if correction is insufficient. Percutaneous interphalangeal joint resection and fusion is less commonly performed. Percutaneous pins are used as needed and removed at 3 weeks.
For interdigital corns of the first web space, patients are offered percutaneous shaving of bone under corn and adductor tenotomy of first metatarsal-phalangeal (MP) joint. Interdigital corns of lessor toes may have percutaneous shaving of bone under corn and capsular release in the lessor toe MP joint in addition if needed.
Inactive high-risk patients with painful arthritis of the first MP joint can be treated initially with percutaneous FHL tenotomy to relieve pain and prevent ulceration with less expected complications than with bone surgery [69]. More commonly, percutaneous resection of bone spurs, dorsal MP joint (cheilectomy)and proximal phalangeal dorsal closing wedge osteotomy is performed [70]. DePrado’s book on percutaneous is an excellent “how to” book on percutaneous foot surgery [70].
For bunions, percutaneous or open chevron metatarsal osteotomy and proximal phalanx osteotomy are performed [70, 71]. Most patients having first ray surgery for arthritis or bunions also have GSR for Achilles tightness. If they have diabetes, GSR will more likely relieve their pain and prevent foot ulcers, Charcot foot and amputation [41, 57]. If they have Achilles tendinitis, posterior tibial tendinitis or dysfunction, midfoot arthritis or metatarsalgia in addition to their first MP pain, they are more likely to have their pain relieved than if they have bunionectomy alone [41, 68].
Additional studies should be done in diabetics to see if frequent eccentric calf stretching can prevent calf tightness, forefoot calluses, forefoot ulceration and Charcot arthritis. Since calf stretching would not harm diabetic patients, this author recommends prophylactic eccentric calf stretching to these patients.
Achilles tendon lengthening has been recommended to prevent re-ulceration in patients with prior ulcers [27]. More studies are needed to confirm tendon lengthening is helpful in preventing ulceration in patients with progressive callus, prior ulcers, and impending ulcers [27] and whether tendon lengthening should be used as part of primary initial treatment for foot ulcers and Charcot foot [41, 57].
Thomas and Huffman recommended lengthening the Achilles in Charcot foot [55]. More studies should also be done to confirm that tendon lengthening heals most midfoot ulcers [2], transmetatarsal stump ulcers [34], and ischemic wounds of forefoot [48, 49]. Further studies are also needed to confirm tendon lengthening prevents Charcot foot, prevents progression of deformity of Charcot arthritis of the midfoot [2, 10] and ankle, and prevents foot ulcers and amputation in patients with Charcot foot [57].
Preliminary results of tendon lengthening have been encouraging; however, further studies need to be done to confirm tendon lengthening relieves foot pain from multiple causes and prevents foot ulcers, arch collapse, arthritis, amputation and other foot problems.
The literature indicates that tendon lengthening is effective treatment for neuropathic forefoot ulcerations and that the complication rate seems to be low. By healing most forefoot ulcerations and lowering their recurrence rate more than all other treatments, this procedure should lower the incidence of progression of metatarsal ulceration to infection and subsequent amputation. More studies need to be done to confirm tendon lengthening is an effective treatment for Charcot foot and other foot problems and confirm tendon lengthening should be part of initial treatment of diabetic foot problems.
The author declares no conflict of interest.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\nAfter approval, you will proceed in submitting your full-length manuscript. 50-130 pages for compacts, 130-500 for Monographs & Edited Books.Your full-length manuscript must follow IntechOpen's Author Guidelines and comply with our publishing rules. Once the manuscript is submitted, but before it is forwarded for peer review, it will be screened for plagiarism.
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"49459",title:"Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration",slug:"pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration",totalDownloads:15494,totalCrossrefCites:17,totalDimensionsCites:24,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"Tarek A. Ahmed",authors:[{id:"175649",title:"Dr.",name:"Tarek A",middleName:null,surname:"Ahmed",slug:"tarek-a-ahmed",fullName:"Tarek A Ahmed"}]},{id:"29240",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:27216,totalCrossrefCites:28,totalDimensionsCites:58,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"66259",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7606,totalCrossrefCites:58,totalDimensionsCites:152,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:4142,totalCrossrefCites:16,totalDimensionsCites:32,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]}],onlineFirstChaptersFilter:{topicId:"19",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83076",title:"Treatments for the Infection by SARS-CoV-2",slug:"treatments-for-the-infection-by-sars-cov-2",totalDownloads:17,totalDimensionsCites:0,doi:"10.5772/intechopen.106232",abstract:"In late 2019, pneumonia cases from unknown origin were detected in Wuhan, China. The cause was a new coronavirus. The World Health Organization (WHO) named the virus SARS-CoV-2 and COVID-19 the associated disease. In the first months of 2020, this disease became a pandemic with a high lethality reported. Since then, the search for treatments began. We started by searching among treatments previously approved for human use that were not designed for COVID-19 and were considered to treat this condition. We continued searching on the therapeutics guidelines published by the WHO for the management of infection by SARS-CoV-2. Based on these results, we searched for the literature in PubMed to obtain further evidence on the drugs against SARS-CoV-2. The treatments presented in this chapter are Ivermectin, Hydroxychloroquine, Nitazoxanide, Azithromycin, Molnupiravir, Casirivimab-Imdevimab, Ritonavir-Nirmatrelvir, Ritonavir-Lopinavir, Remdesivir, and Favipiravir. Two years ahead of the start of the COVID-19 pandemic, a plenty of options for treatment have been investigated. Only a few of them have been shown to be efficient and safe. According to the WHO, Ritonavir-Nirmatrelvir outperforms other proposed therapeutics.",book:{id:"11690",title:"COVID-19 Drug Development - Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg"},signatures:"Nicolás Padilla-Raygoza, Gilberto Flores-Vargas, María de Jesús Gallardo-Luna, Efraín Navarro-Olivos, Francisco Javier Magos-Vázquez and Daniel Alberto Díaz-Martínez"},{id:"83054",title:"Pulsatory Liposome: A Possible Biotechnological Device",slug:"pulsatory-liposome-a-possible-biotechnological-device",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106347",abstract:"A unilamellar liposome filled with an osmotic solution is introduced into a hypotonic aqueous environment. Because of the mechanical tension induced by the osmotic flow, the vesicle swells up to a critical size, when suddenly a transbilayer pore appears and the vesicle relaxing stage starts. A part of the intracellular material leaks out through this pore, and the liposome membrane relaxes and finally recovers. The swelling begins again and the liposome experiences a periodical process. For this reason, we have named it a pulsatory liposome. The swelling of the liposome is described by a differential equation. All the processes which contribute to the vesicle relaxing and its coming back to the initial size are described by three differential equations. The pulsatory liposome can be programmed to work a number of cycles, established before. The activity of a pulsatory liposome can be characterized by the following parameters: (a) number of cycles, the length time of each cycle, and liposome activity life; (b) the length time of the swelling stage and the relaxation stage for each cycle; (c) the amount of solute leaked out through the pore in each cycle. The pulsatory liposome may be regarded as a two-stroke engine.",book:{id:"11814",title:"Liposomes - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11814.jpg"},signatures:"Dumitru Popescu and Alin Gabriel Popescu"},{id:"82962",title:"Pluralism Medical Treatment, Prevention, and Control of COVID-19 Infection and Its Long-Sufferings among the Older Adults in the Northeast of Thailand from 2019 to 2022",slug:"pluralism-medical-treatment-prevention-and-control-of-covid-19-infection-and-its-long-sufferings-amo",totalDownloads:51,totalDimensionsCites:0,doi:"10.5772/intechopen.106339",abstract:"COVID-19 in 2019 has brought both changes and challenges to the world. This global pandemic has an impact on people of all age levels, especially older adults. In Thailand, older persons are at high risk of COVID-19 infection. They are included in the so-called 608 groups. The objective of this review article was to synthesize and present medical pluralism, the development of drugs from herbs, and projects conducted to treat, prevent, and control the infection and long sufferings of COVID-19. The review covers 10 studies, three projects produced at Mahasarakham University, Chaiyaphum Rajabhat University, and Khon Kaen University that were reviewed, synthesized, and analyzed. The results of the synthesis indicate that modern and Thai traditional medicine can help reduce the severity of the infection and long sufferings of COVID-19. The medical pluralism between modern and Thai traditional medicine is needed to remedy COVID-19 cases among the older adults in the Northeast of Thailand.",book:{id:"11690",title:"COVID-19 Drug Development - Recent Advances, New Perspectives, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11690.jpg"},signatures:"Pissamai Homchampa, Khemika Napattaradechanon, Parichat Yatniyom, Thawalrat Ratanasiri, Piyaporn Sansila, Thanawan Sirisuk, Thawalwong Ratanasiri and Amornrat Ratanasiri"},{id:"82353",title:"Pharmacovigilance of Biological Drugs",slug:"pharmacovigilance-of-biological-drugs",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.105520",abstract:"The use of biological drugs has significantly increased over the past decades and has allowed for the treatment of many life-threatening and chronic diseases. The patent expiration of biological innovative medicines enables copies of these drugs called biosimilars. The availability of biosimilars enhances competition, with the potential to improve patient access to biological medications and contribute to the financial sustainability of the healthcare systems. Unlike equivalent drugs, biosimilars are not identical but similar to their innovator products because of the differences in the manufacturing process, which is a biological process. However, they are considered comparable to their originators in safety, quality characteristics, biological activity, and efficacy. The regulatory procedures used for generic drugs cannot be applied for biosimilars, so they are subjected to rigorous characterization as well as comparative clinical studies. Since they are highly complex molecules produced from living cells, even small change in the production process can have major implications on their safety and effectiveness profile, causing a potential risk of immune-based adverse reactions. For all these reasons, for biological drugs, a robust long-term pharmacovigilance system is necessary. It is desirable that in the future, there are further guidance and resolution of the ongoing discussions on biosimilar labeling, naming, pharmacovigilance and interchangeability/substitution, to ensure the appropriate use of these drugs in clinical practice.",book:{id:"11679",title:"Pharmacovigilance and Regulations",coverURL:"https://cdn.intechopen.com/books/images_new/11679.jpg"},signatures:"Simona Guerzoni, Flavia Lo Castro, Carlo Baraldi, Giuliana Colella and Luca Pani"},{id:"82868",title:"Recent Strategies for Ocular Drug Delivery: Promises and Challenges",slug:"recent-strategies-for-ocular-drug-delivery-promises-and-challenges",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.106335",abstract:"Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers. The emerging nanoscience is playing an important role in the development of novel strategies for ocular disease management. Various active molecules have been designed to associate with nanocarriers to overcome ocular barriers and interact with certain ocular tissues. In this chapter, highlights will be made on barrier to intraocular delivery, general pathways for ocular absorption, and factors affecting intraocular bioavailability. The recent attempts of nanotechnology for treating anterior and posterior ocular diseases will be explored. This will include nanomicelles, nanoparticles, nanosuspensions, vesicular systems, in situ gel, dendrimers, contact lenses, implants, microneedles, and cell-based delivery systems. In addition, gene-based ocular delivery systems will be discussed. In this chapter, we will also provide a comprehensive overview of drug-device combinations used for ocular diseases such as glaucoma, dry eye disease, infections, and inflammations. Furthermore, drug delivery devices for ocular surgeries are discussed. Finally, challenges and future prospective of ocular delivery systems will be explored.",book:{id:"11688",title:"Advances in Drug Delivery Methods",coverURL:"https://cdn.intechopen.com/books/images_new/11688.jpg"},signatures:"Amal H. El-Kamel and Asmaa A. Ashour"},{id:"82727",title:"Mesoporous Silica Based Cancer Theranostic: A Modern Approach in Upcoming Medicine",slug:"mesoporous-silica-based-cancer-theranostic-a-modern-approach-in-upcoming-medicine",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105447",abstract:"In case cancers are located deep inside the body and are very tough to diagnose, diagnostic tools like MRI/CT scans can be employed to detect these cancers. The major challenge in such cases is the delivery of MRI active agents or visualizing agents to the target site. In this context we will discuss different mesoporous nanoparticles that can be employed to target the tissue at a specific location, its functionalization to reach the target site (Folic acid), different simple dyes as well as specific dyes which offer theranostic functionality. The nanoparticles like mesoporous silica nanoparticles offer the possibility to load therapeutic and diagnostic agents. Its surface allow multiple functionalization and conjugations which offer target specific delivery of these agents. Moreover we will also overview different modern drug delivery inventions for offering theranostic application.",book:{id:"11688",title:"Advances in Drug Delivery Methods",coverURL:"https://cdn.intechopen.com/books/images_new/11688.jpg"},signatures:"Ajinkya Pote, Vikas Ahirrao and Vishal Pande"}],onlineFirstChaptersTotal:54},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:755,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. 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He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. 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