Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 179 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 252 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
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1. Introduction
Substitution reaction is one of the important classes of organic reactions. The term substitution itself indicates that the organic reaction process in which the one moiety/functional group will be replaced by other new group/moiety. Generally, there are two types of substitution reactions: one is bimolecular substitution reaction and the other is unimolecular substitution (SN1) reaction. The bimolecular reaction is a reaction in which the replacing group generates partially a positive charge on a substrate and a new electron-rich group occupies the position of the replacing group as shown in Figure 1. In short, it is referred as bimolecular nucleophilic substitution reactions (SN2) [1]. Aliphatic nucleophilic substitution reaction is generally performed in a non-protic solvent so that the nucleophile will be free and flexible to replace the leaving group. In case of a protic solvent, the electron-rich species of nucleophile forms the hydrogen bond; thus, it reduces the efficiency of nucleophile, decreases nucleophilicity, and reduces the reaction rate. By contrast, some reactive nucleophiles, which show duel characters, may act as a base as well as a nucleophile; in such case, the possibility to form other side products are more. To improve the selectivity of the product, hydrogen bonding with reactive nucleophile will play a key role. Thus, a number of nucleophilic substitution reactions are performed in protic solvents such as tert-butanol, alcohol-functionalized ionic liquids, ammonium ionic liquids, or polyethylene glycols. In this book chapter, the recent development of SN2 reactions in protic solvent to improve the selectivity of substituted product is covered [2].
Figure 1.
Substitution reactions with metal nucleophile (MNu) in protic solvent.
2. Protic solvent substitutions
2.1 Alcohol-mediated substitution reactions
Chi et al. developed the nucleophilic substitution reactions using tert-alcohol solvents such as tert-butanol, tert-amyl alcohol, etc [3]. Nucleophiles such as fluorine gave promising results and an excellent desire for the selectivity of fluorinated product with low formation of corresponding by-product alkene. Figure 1 shows the alkyl sulfonate leaving group replaced by fluorine efficiently in the tert-amyl alcohol-mediated reaction conditions. The extreme effect of protic solvent-mediated fluorination with alkali metal fluoride was demonstrated.
They observed that the alcohol solvent particularly nonpolar such as tert-alcohol enhances the nucleophilicity of the electron-rich nucleophilic ion, radically in lack of any type of promoter or phase-transfer catalyst, which significantly enhances the rate of the nucleophilic substitutions and reduces the generation of corresponding side products, i.e. alcohols, ethers and alkene, compared with substitution reactions in dipolar aprotic medium. The importance of this reaction method is that it is useful in radiopharmaceuticals for the synthesis of fluorine-18-labelled imaging agents for positron emission tomography (PET) [4]. They demonstrated the application of protic-mediated reactions for radiolabelling of important molecular imaging agents in good yield and quality in shorter time compared to aprotic-mediated reaction conditions of nucleophilic substitution reactions [5]. They further studied the influence of the tert-alcohol solvent conditions for nucleophilic substitutions with series of alkali metal fluorides. The possible hydrogen bonding interaction of nucleophile fluorine and the sulfonyloxy substrate promote the rate of reaction [6]. Mechanistically, the hydrogen bonding between alkali metal fluoride and aprotic solvent, the generation of protic alcohol-solvated ion and the hydrogen bonding between the leaving group sulfonate and the alcohol solvent seem to favour the enhancement in the rate of nucleophilic substitutions without PTC. They found that the fluorination with specific substrates with tert-butylammonium fluoride in alcohol solvent affords the corresponding fluoroproducts in high yield than that obtained by the conventional methods using dipolar aprotic solvents. The protic medium also suppresses the formation of by-products, such as alkenes, ethers and cyclic adducts.
2.2 Tert-alcohol-functionalized ionic liquid
Shinde et al. exhibited the synergistic effect of tert-alcohol and ionic liquids in substitution reactions [7]. They merged the two solvents, ionic liquid (IL) and tert-alcohols, into one molecule for nucleophilic substitution as shown in Figure 2. These hybridised ILs not only increase the nucleophilic reactivity of the fluoride anion but also reduce the olefin by-product. The preparation of novel imidazolium salts with counter anion [8]. Imidazole reacted with isobutylene oxide without or free solvents to give quantitatively yield N-tert-alcohol-substituted imidazole. N-tert-alcohol-substituted imidazole reacted with methyl, isopropyl, n-butyl, n-hexyl methane sulphonate in acetonitrile at 90°C gave the corresponding N1-alkyl-N3-tert-alcohol substituted imidazolium salts (ILs) 1a–1d. All of these imidazolium mesylates are liquids at room temperature.
Figure 2.
Synthesis of tert-alcohol-functionalized ionic liquid for substitution reactions.
In the development of the fluorination process, ILs play both roles, i.e. reaction media and phase-transfer catalysts. They found that nucleophilic fluorination is accelerated in 1a and that tert-alcohol solvents show good performance in nucleophilic fluorination, thereby side reactions are remarkably suppressed via a weak F▬H hydrogen bond, which maintains the inherent nucleophilicity and reduces the basicity of the fluoride anion. The new hybridization of ILs and tert-alcohol functionality would provide dual advantages of reaction acceleration and minimization of side reactions.
Figure 3 depicted the use of protic ionic liquid in nucleophilic fluorination. The reaction of the primary triflate of R-D-galactopyranose in the presence of 1a as a protic catalyst yielded the fluorinated product (6a) in almost quantitative yield with no by-products [7].
Figure 3.
Nucleophilic fluorination by protic ionic liquid 1a.
The reaction of the secondary mesylate, which could easily be eliminated to the corresponding olefin, showed a similar trend. Such superior reactivity and selectivity were obviously due to the previously mentioned synergistic effect of tert-alcohol functionality and imidazolium salts (Figure 4) [9].
Figure 4.
Nucleophilic fluorination on secondary mesylate by using CsF and 1a.
2.3 Protic ethylammonium nitrate
Crosio et al. developed a new protic ionic liquid (IL) ethylammonium nitrate (EAN) inside toluene/benzyl-n-hexadecyldimethylammonium chloride (BHDC) as shown in Figure 5 and studied its application on reverse micelles affects [10]. They found the Cl ion nucleophilicity on the bimolecular nucleophilic substitution (SN2) reaction between this anion and dimethyl-4-nitrophenylsulfonium trifluoromethanesulfonate. It was the first study where the polar EAN was used as a suitable reaction medium for toluene-BHDC reverse micelles as a nanoreactor for performing the kinetic studies. The light scattering experiment discloses the formation of RMs containing the protic EAN ionic liquid component. Their experiments demonstrate that the homogeneous reaction medium is low effective compared to EAN-mediated SN2 reaction conditions. The protic ionic liquid EAN acts as a aprotic medium once it is entrapped in BHDC RMs by hydrogen bonding interactions; as a result, nucleophilicity of chloride increases dramatically. Thus, the protic EAN is found as a suitable reaction solvent for nucleophilic bimolecular substitution reactions. These experiments demonstrate the flexibility of this kind of nanoreactor system to alter the polar protic solvent trapping and its impact on the rate of the reaction.
Figure 5.
Structures of ethylammonium nitrate (EAN).
2.4 Polar protic solvent glycol
Song et al. observed that the alcohol contained polyethylene glycol as good reaction media for various nucleophilic substitution reactions [10]. Achiral polyether derivatives have shown dramatic acceleration in the SN2 reactions by the simultaneous activation of both the nucleophile and electrophile sites of the leaving group. They also studied desiylation and found that bis-terminal ▬OH group plays a key role that the desilylative kinetic resolution is successively done of the silyl ethers of racemic secondary alcohols.
2.5 Primary alcohol-functionalized ionic liquid
Further, polyethylene glycol was used for functionalization of imidazolium-based ionic liquid and studied for SN2 reactions. Kim et al. [12] synthesised hexaehtylene glycol chain ILs [hexaehtylene glycol-im][OMs] and [dihexaehtylene glycol-im][OMs] (hexaehtylene glycol-im = 1-hexaethylene glycolic 3-methylimidazolium cation; dihexaehtylene glycol-im = 1,3-dihexaethylene glycolic imidazolium cation; OMs = mesylate anion) by using simple organic reaction process as shown in Figure 6 [11]. Synthesized various lengths of oligoether was have better chelation efficiency with metal cation due to presence of oxygen atoms intraction from both side of imidazolium IL.
Figure 6.
Synthesis of polar-aprotic glycol substituted imidazolium ionic liquids. A) mono-glycol chain substituted IL, B) bis-glycol chain substituted IL.
The author described the role of all functional moieties of ionic liquid in nucleophilic fluorination by using salts of metal nucleophiles (Figure 7).
The application of di-functional polyether chain-substituted imidazolium ionic liquids in the synthesis of various bioactive molecules such as fluoro-flumazenil, fluoropropyl ciprofloxacin, etc., which are useful in molecular probes for PET, is synthesised using a protic ionic liquid as shown in Figure 8.
Figure 8.
Fluorination reaction by using bis-glycol substituted ILs catalyst with various leaving groups. A) acyl bromide B) tosylate C) mesylate substrates.
The same research group developed another dicationic protic ionic liquid for substitution reactions. A task-specific hexaethylene glycol bridged bis-cationic ionic liquid (BFIL) such as bis(2-hydroxy-2-methyl-n-propylimidazolium) dimesylate (hexaehtylene glycol chain-DtOHIM) was prepared, and its role in nucleophilic substitution reactions using an alkali metal nucleophiles was investigated [13]. They also compared their activities with a variety of mono-cationic ILs and found that the hexaehtylene glycol chain-functionalized IL more effectively enhanced the reactivity of KX compared with the tert-alcohol-functionalized IL hexaehtylene glycol chain-DtOHIM (Figure 9).
The use of bis-functionalized ionic liquid (BFIL) enhances the substitution reaction rate compared to conventional ionic liquid as well as mono-functionalized protic ionic liquid due to the higher activity of BFIL by the additional dicationic moieties compared with the mono-cationic ionic liquid methods. The author found that the hexaethylene glycol moiety of these hexaehtylene glycol chain-functionalized ILs enhances the reactivity of alkali metal fluorides by two effects; one is chelation effect with alkali metal cations, allowing the fluoride to become necked, and the other is the flexible fluoride influence by flexible H-bonding between the hydroxyl groups of BFIL, t-alcohol medium and nucleophile. In the case of t-alcohol-functionalized BFIL, the t-alcohol moiety showed selectively flexible H-bonding in the process. Subsequently, bi-alcohol-functionalized BFIL, having two imidazolium cations functionalized by ethylene glycol chain, showed the excellent catalytic increases in the reactivity of metal fluoride in the nucleophilic substitution among the mono-cationic convention ionic liquids. Tert-alcohol-funtionlaized ionic liquid not only enhances the nucleophilicity of ion but also reduces the formation of by-products alkene and ether.
The reaction of fluorination on another base-sensitive substrate of secondary alkyl tosylate using hexaehtylene glycol chain-DHIM with KF in t-amyl alcohol at 80°C got a better yield of the secondary fluoro-product (Figure 10).
Figure 10.
Fluorination on secondary tosylate using KF with hexaehtylene glycol chain-DHIM.
2.7 Protic amine tri-tert-butanolamine
Shinde et al. developed novel series of protic amines, i.e. tri-tert-butanol amine, which can be used as catalyst or media for substitution reactions [14]. Tert-butanol-functionalized amines were prepared as shown in Figure 11. The easy synthesis of this amine was solvent-free reaction of isobutylene oxide with respective amines to afford corresponding tri-tert-butanolamine [(tri-tBuOH)A, 1-[Ethyl(2-hydroxy-2-methylpropyl)amino]-2-methylpropan-2-ol [(di-tBuOH)EtA) and 1-(diethylamino)-2-methyl-2-propanol [(mono-tBuOH)EtA]. These protic amines act as promoters with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances the reactivity of alkali metal salts with the minimum formation of side products (alkene, ether and alcohol) compared to conventional phase-transfer catalyst. The synergism of tert-alcohol and amine moiety plays a pivotal role in fluorination.
Figure 11.
Synthesis of various tert-butanol amines.
Fluorination reactions on the secondary leaving group of natural steroid substrate, cholesterol that was successfully converted into 2-fluoro-cholesterol in reasonable good yield (Figure 12).
Figure 12.
Nucleophilic fluorination on secondary substrate with metal salts using t-butanolamine.
The reaction of OTf-containing substrate in the presence of promoter t-butanolamine was much faster in giving the desired fluoro-product. It gave good substitution reactions with other leaving groups such as O-tosylate and O-nosylate as shown in Figure 13.
Figure 13.
Fluorination on primary substrate in the presence of t-BuOH-amine.
Substitution reactions with reactive substrate such as bromoacetophenone to fluoro acetophenone gave poor conversion of corresponding fluorinated product, Figure 14. It may be due to the tert-butanolamine that may react with acyl bromide and form the corresponding quaternary salts.
Figure 14.
Acyl bromide substitution reactions in presence of tert-butanol amine.
The reaction could be conducted in acetonitrile on a wide variety of substrates with little alkene formation observed. Further, Lee et al. studied the quantum chemical calculations of these substitution reactions and suggested that tris-tert-buntenolamine complexed the fluoride ion through multiple O▬H⋯nucleophile▬hydrogen bonds during the nucleophilic substitution reaction [15]. The formation of such complex did not have an effect on the reactivity of nucleophilicity and gave a selective substituted product.
3. Conclusion remark
In conclusion, the book chapter covers the recent development of protic solvents as reaction media of various substitution reactions. Aliphatic nucleophilic substitution reactions were extensively investigated in protic reaction medium and were found to be better reaction media compared to conventional aprotic solvents conditions. The protic solvents such as tert-amyl alcohol, tert-butanol, tert-alcohol-functionalized ionic liquid and amine are being widely used in fluorination reactions. These solvents are adopted by radiopharmaceuticals for the synthesis of value-added imaging agents for PET. The use of protic solvents is easy access and easy handling due to high-boiling points; they can be easily separated from the product because most of them are water soluble. The primary alcohol and tert-alcohol ionic liquids are not only used as solvents but also as promoters in various substitution reactions. These protic ionic liquids are ecofriendly and easy to synthesize and recover it after reactions.
\n',keywords:"substitution reactions, nucleophilic, alcohol solvents, phase transfer catalyst",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/72451.pdf",chapterXML:"https://mts.intechopen.com/source/xml/72451.xml",downloadPdfUrl:"/chapter/pdf-download/72451",previewPdfUrl:"/chapter/pdf-preview/72451",totalDownloads:89,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 20th 2019",dateReviewed:"January 28th 2020",datePrePublished:"June 11th 2020",datePublished:null,dateFinished:null,readingETA:"0",abstract:"This chapter deals with the unusual substitution reactions in non-aprotic solvent. Selective protic solvents that are widely being accepted for nucleophilic substitution reactions not only enhance the reaction rate but also give desire for selectivity of substituted product. Protic solvents such as tert-alcohol, primary alcohol, ionic liquids with tert-alcohol and primary alcohol functionality, and bis-cationic ionic liquid with protic functionality were shown best result in substitution reactions. Aliphatic nucleophilic substitution significantly developed in protic reaction medium due to the hydrogen bonding interaction with leaving groups and nucleophile. The development of substitution reactions from past two decades are summarised in this book chapter.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/72451",risUrl:"/chapter/ris/72451",signatures:"Sandip S. Shinde",book:{id:"8085",title:"Photophysics, Photochemical and Substitution Reactions- Recent Advances",subtitle:null,fullTitle:"Photophysics, Photochemical and Substitution Reactions- Recent Advances",slug:null,publishedDate:null,bookSignature:"Dr. Satyen Saha, Dr. Ravi Kumar Kanaparthi and Dr. Tanja V. Soldatovic",coverURL:"https://cdn.intechopen.com/books/images_new/8085.jpg",licenceType:"CC BY 3.0",editedByType:null,editors:[{id:"226917",title:"Dr.",name:"Satyen",middleName:null,surname:"Saha",slug:"satyen-saha",fullName:"Satyen Saha"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Protic solvent substitutions",level:"1"},{id:"sec_2_2",title:"2.1 Alcohol-mediated substitution reactions",level:"2"},{id:"sec_3_2",title:"2.2 Tert-alcohol-functionalized ionic liquid",level:"2"},{id:"sec_4_2",title:"2.3 Protic ethylammonium nitrate",level:"2"},{id:"sec_5_2",title:"2.4 Polar protic solvent glycol",level:"2"},{id:"sec_6_2",title:"2.5 Primary alcohol-functionalized ionic liquid",level:"2"},{id:"sec_7_2",title:"2.6 Di-tert-alcohol-functionalized dicationic ionic liquid",level:"2"},{id:"sec_8_2",title:"2.7 Protic amine tri-tert-butanolamine",level:"2"},{id:"sec_10",title:"3. Conclusion remark",level:"1"}],chapterReferences:[{id:"B1",body:'Shinde SS, Patil SN, Thore SN, Pawar RP, Ametha KL. Synthesis of fluorinated heterocyclic molecule via multicomponent reactions. In: Multicomponent Reactions. Synthesis of Bioactive Heterocycles. Taylor and Francis Group, CRC Press; 2017. Chap. 7'},{id:"B2",body:'Lee J-W, Oliveira MT, Jang HB, Lee S, Chi DY, Kim DW, et al. Hydrogen-bond promoted nucleophilic fluorination: Concept, mechanism and applications in positron emission tomography. Chemical Society Reviews. 2016;45:4638-4650'},{id:"B3",body:'Kim DW, Song CE, Chi DY. New method of fluorination using potassium fluoride in ionic liquid: Significantly enhanced reactivity of fluoride and improved selectivity. Journal of the American Chemical Society. 2002;124:10278-10279'},{id:"B4",body:'Kim DW, Song CE, Chi DY. Significantly enhanced reactivities of the nucleophilic substitution reactions in ionic liquid. The Journal of Organic Chemistry. 2003;68:4281-4285'},{id:"B5",body:'Kim DW, Ahn D-S, Y-Ho O, Lee S, Kil HS, Oh SJ, et al. A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules. Journal of the American Chemical Society. 2006;128:16394-16397'},{id:"B6",body:'Kim DW, Jeong ST, Lim M-H, Sohn JA, Katzenellenbogen DYC. Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: Significantly enhanced reactivity of alkali metal fluorides and improved selectivity. The Journal of Organic Chemistry. 2008;73:957-962'},{id:"B7",body:'Shinde SS, Lee BS, Chi DY. Synergistic effect of two solvents, tert-alcohol and ionic liquid, in one molecule in nucleophilic fluorination. Organic Letters. 2008;10:733-735'},{id:"B8",body:'Shinde SS, Chi HM, Lee BS, Chi DY. tert-Alcohol-functionalized imidazolium ionic liquid: Catalyst for mild nucleophilic substitution reactions at room temperature. Tetrahedron Letters. 2009;50:6654-6657'},{id:"B9",body:'Shinde SS, Patil SN, Ghatge A, Kumar P. Nucleophilic fluorination using imidazolium based ionic liquid bearing tert-alcohol moiety. New Journal of Chemistry. 2015;39:4368-4374'},{id:"B10",body:'Crosio MA, Correa NM, Silber JJ, Falcone RD. A protic ionic liquid, when entrapped in cationic reverse micelles, can be used as a suitable solvent for a bimolecular nucleophilic substitution reaction. Organic & Biomolecular Chemistry. 2016;14:3170-3177'},{id:"B11",body:'Lee JW, Hyeong HY, Hong BJ, Kim K, Park S-W, Lee S, et al. Bis-terminal hydroxy polyethers as all-purpose, multifunctional organic promoters: A mechanistic investigation and applications. Angewandte Chemie, International Edition. 2009;48:7683-7686'},{id:"B12",body:'Jadhav VH, Jeong H-J, Lim ST, Sohn M-H, Kim DW. Tailor-made hexaethylene glycolic ionic liquids as organic catalysts for specific chemical reactions. Organic Letters. 2011;13:2502-2505'},{id:"B13",body:'Jadhav VH, Kim JG, Park SH, Kim DW. Task-specific hexaethylene glycol bridged di-cationic ionic liquids as catalysts for nucleophilic fluorination using potassium fluoride. Chemical Engineering Journal. 2017;308:664-668'},{id:"B14",body:'Shinde SS, Khonde NS, Kumar P. Tri-tert-butanolamine as an organic promoter in nucleophilic fluorination. ChemistrySelect. 2017;2:118-122'},{id:"B15",body:'Lee S-S, Jung H-K, Shinde SS, Lee S. Mechanistic study of nucleophilic fluorination promoted by tri-tert-butanolamine. Journal of Fluorine Chemistry. 2017;197:80-86'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Sandip S. Shinde",address:"shinde88@gmail.com",affiliation:'
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His interest is the research and development of catalytic and biotechnological processes for the transformation of biomass-derived molecules to compounds of technological and industrial interest. With this aim, Israel Pala-Rosas focuses his work on the synthesis, characterization, and testing of catalysts, as well as the design and analysis of chemical and biochemical reactors. Areas related to the catalytic processes, such as chemical thermodynamics, unit operations and economics, are also under his scope.",institutionString:"Instituto Politécnico Nacional",institution:{name:"Instituto Politécnico Nacional",institutionURL:null,country:{name:"Mexico"}}},{id:"284262",title:"Dr.",name:"Jose",surname:"Salmones",slug:"jose-salmones",fullName:"Jose Salmones",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"284263",title:"Dr.",name:"Beatriz",surname:"Zeifert",slug:"beatriz-zeifert",fullName:"Beatriz Zeifert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"284730",title:"Dr.",name:"Priya",surname:"Samudrala",slug:"priya-samudrala",fullName:"Priya Samudrala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:null,institutionString:null,institution:{name:"Monash University",institutionURL:null,country:{name:"Australia"}}},{id:"285216",title:"Prof.",name:"Toshiaki",surname:"Yamashita",slug:"toshiaki-yamashita",fullName:"Toshiaki Yamashita",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"286992",title:"Ms.",name:"Linlin",surname:"Zhu",slug:"linlin-zhu",fullName:"Linlin Zhu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"295779",title:"Prof.",name:"Jose Luis",surname:"Contreras",slug:"jose-luis-contreras",fullName:"Jose Luis Contreras",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"OA-publishing-fees",title:"Open Access Publishing Fees",intro:"
The Open Access model is applied to all of our publications and is designed to eliminate subscriptions and pay-per-view fees. This approach ensures free, immediate access to full text versions of your research.
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The Open Access Publishing Fee (OAPF) is payable only after your full chapter, monograph or Compacts monograph is accepted for publication.
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Services included are:
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An online manuscript tracking system to facilitate your work
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
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XML Typesetting and pagination - web (PDF, HTML) and print files preparation
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Permanent and unrestricted online access to your work
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Exceeds 20 pages (for chapters in Edited Volumes), an additional fee of 40 GBP per page will be required
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Open Access Funding
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To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at oapf@intechopen.com for further details or assistance.
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For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Indexing and listing across major repositories, see details ...
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Visibility on the world's strongest OA platform
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Proven world leader in Open Access book publishing with over 10 years experience
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Currently strongest OA platform with over 130 million downloads
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