Kanya Honoki

Nara Medical University Japan

Dr. Kanya Honoki is an associate professor and the chief of the musculoskeletal oncology unit in the Department of Orthopedic Surgery, Arthroplasty, and Regenerative Medicine at Nara Medical University, Japan. After the acquisition of his Ph.D. degree at Nara Medical University, he finished his postdoctoral fellowship at Jefferson Medical College. He has devoted his effort, energy, and passion to the field of orthopedic oncology, especially both basic and clinical pathogenesis of the disease progression in sarcomas. Dr. Honoki is also engaged in the research of cancer and stem cell biology and regenerative and restorative medicine. He is an active member of the American and European Association for Cancer Research and International Society for Stem Cell Research, the Japanese Cancer Association, and the Japanese Orthopedic Association and has numerous publications in these areas.

1books edited

3chapters authored

Latest work with IntechOpen by Kanya Honoki

Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

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Osteosarcoma

Edited by Kanya Honoki

Chapters authored

Cancer Stem Cell Niche: The Role of Mesenchymal Stem Cells in Tumor Microenvironment 189

By Kanya Honoki, Hiromasa Fujii and Toshifumi Tsujiuchi

Part of the book: Cancer Stem Cells

Introductory Chapter: From Chaos to Cosmos – Toward Precision Medicine in Osteosarcoma

By Kanya Honoki and Kurt Richard Weiss

Part of the book: Osteosarcoma

A Novel Strategy of Dual Inhibition of Distinct Metabolic Features in Osteosarcoma

By Shingo Kishi, Kanya Honoki, Yasuhito Tanaka and Hiroki Kuniyasu

Mitochondria are the places for the energy production of the cells, while reactive oxygen species (ROS) are also produced alongside. In recent years, it has been reported that cancer stem cells metabolize predominantly through oxidative phosphorylation (OXPHOS) rather than glycolysis. Targeting OXPHOS achieved by suppression of ATP synthesis through mitochondrial ATP synthase could be a potential therapeutic option against cancer stem cells. Since c-Myc inhibition is considered to lead a metabolic flux to OXPHOS from glycolysis, the combinatory inhibition of both OXPHOS and glycolysis could be a strong candidate for the treatment of malignant tumors. In this chapter, we will discuss about the mitochondria metabolism as the potential therapeutic target in osteosarcoma stem cells, and the synergistic effects of combination of OXPHOS inhibitor with c-Myc inhibitor, which target both OXPHOS-dominant cancer stem cells and glycolysis-dominant non-cancer stem cells, will be discussed.

Part of the book: Osteosarcoma

Kanya Honoki

Latest work with IntechOpen by Kanya Honoki

Osteosarcoma

Chapters authored

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