Variation of fenugreek secondary metabolites in different cultural applications.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6368",leadTitle:"Lubrication",fullTitle:"Lubrication - Tribology, Lubricants and Additives",title:"Tribology, Lubricants and Additives",subtitle:null,reviewType:"peer-reviewed",abstract:"Tribology is an interdisciplinary area that studies the reduction of friction between moving parts combining chemistry, physics and engineering disciplines. Lubricants are typically substances used to reduce friction. This book contains two sections: the first section examines the chemistry of lubricants and additives, while the second section looks at the lubrication of different types of materials.",isbn:"978-1-78923-129-8",printIsbn:"978-1-78923-128-1",pdfIsbn:"978-1-83881-434-2",doi:"10.5772/intechopen.69833",price:119,priceEur:129,priceUsd:155,slug:"lubrication-tribology-lubricants-and-additives",numberOfPages:132,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"5c3d14346e656a204a188be6e9bbbea1",bookSignature:"David W. Johnson",publishedDate:"May 23rd 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6368.jpg",numberOfDownloads:7753,numberOfWosCitations:15,numberOfCrossrefCitations:14,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:25,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:54,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 25th 2017",dateEndSecondStepPublish:"June 15th 2017",dateEndThirdStepPublish:"December 3rd 2017",dateEndFourthStepPublish:"January 3rd 2018",dateEndFifthStepPublish:"March 3rd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"178441",title:"Dr.",name:"David",middleName:null,surname:"Johnson",slug:"david-johnson",fullName:"David Johnson",profilePictureURL:"https://mts.intechopen.com/storage/users/178441/images/5646_n.jpg",biography:"David W. Johnson is the Chair of the Chemistry Department at the University of Dayton. He received a Ph.D in chemistry at Illinois Institute of Technology in 1983, completing his research in inorganic chemistry. He has been on the faculty at the University of Dayton teaching primarily analytical chemistry since 1984. He has led an active research program focused on the chemistry of lubricants, lubricant additives and lubricated surfaces in aerospace and refrigeration applications.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Dayton",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"813",title:"Engineering Mechanics",slug:"mechanical-engineering-engineering-mechanics"}],chapters:[{id:"58276",title:"Ab-Initio Modeling of Lubricant Reactions with a Metal Al (111) Surface",doi:"10.5772/intechopen.72512",slug:"ab-initio-modeling-of-lubricant-reactions-with-a-metal-al-111-surface",totalDownloads:925,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In this chapter, to assist the design of aluminum processing, density functional theory is utilized to depict optimal adsorption geometries on an Al (111) surface for two commonly used boundary-layer lubricant additives: vinyl-phosphonic and acetic acids, i.e., tri-bridged, bi-bridged, and uni-dentate coordinations of these adsorbates are examined to determine the optimal binding sites on the surface. During these static analyses, charge density of states for molecular oxygen ions reacting with Al ions in the surface is applied to revealing the evolution essentials of molecular binding strength on surface. In addition, ab-initio molecular dynamics based upon density functional theory is employed to probe dynamic decomposition pathways on the Al (111) surface for two other important boundary-layer lubricant additives: butanoic acid and butanol alcohol. These decomposition pathways may occur upon molecular collisions with the surface, leading to formation of molecular pieces adhering on surface. Simulations are found to be in qualitative accord with existing experimental observations.",signatures:"Jun Zhong",downloadPdfUrl:"/chapter/pdf-download/58276",previewPdfUrl:"/chapter/pdf-preview/58276",authors:[{id:"187258",title:"Prof.",name:"Jun",surname:"Zhong",slug:"jun-zhong",fullName:"Jun Zhong"}],corrections:null},{id:"58293",title:"Antioxidants Classification and Applications in Lubricants",doi:"10.5772/intechopen.72621",slug:"antioxidants-classification-and-applications-in-lubricants",totalDownloads:2101,totalCrossrefCites:12,totalDimensionsCites:17,hasAltmetrics:0,abstract:"Oxidation is a chemical reaction that occurs in lubricants upon exposure to an oxidizing agent such as oxygen and can be catalyzed by copper and iron. Antioxidants are a group of chemicals that can be used in the formulation of lubricants to stop or reduce the rate of oxidation. Based on the mechanism of action, antioxidants are categorized as primary antioxidants (radical scavengers), secondary antioxidants (Peroxide decomposers), and metal deactivators (complex-forming or chelating agents). Selection of the antioxidants in a formulation is a critical decision that depends on the base oil, application and other ingredients in the formulations. Presence of some other ingredients in the product with antagonistic behavior may suppress the role of antioxidants; however, optimal application of antioxidants with synergistic behavior would increase the stabilization impact of the ingredients on the base oil.",signatures:"Majid Soleimani, Leila Dehabadi, Lee D. Wilson and Lope G. Tabil",downloadPdfUrl:"/chapter/pdf-download/58293",previewPdfUrl:"/chapter/pdf-preview/58293",authors:[{id:"31671",title:"Prof.",name:"Lope",surname:"G. Tabil",slug:"lope-g.-tabil",fullName:"Lope G. Tabil"},{id:"109706",title:"Dr.",name:"Majid",surname:"Soleimani",slug:"majid-soleimani",fullName:"Majid Soleimani"},{id:"214500",title:"Mrs.",name:"Leila",surname:"Dehabadi",slug:"leila-dehabadi",fullName:"Leila Dehabadi"},{id:"214501",title:"Dr.",name:"Lee",surname:"Wilson",slug:"lee-wilson",fullName:"Lee Wilson"}],corrections:null},{id:"58266",title:"Tribological Interaction of Bio-Based Metalworking Fluids in Machining Process",doi:"10.5772/intechopen.72511",slug:"tribological-interaction-of-bio-based-metalworking-fluids-in-machining-process",totalDownloads:1171,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Metalworking fluids were applied during the machining process to lubricate and cool the machine tool in order to reduce wear, friction, and heat generated. The increasing attention to the environment and health impacts leads to the formulation of eco-friendly metalworking fluids derived from vegetable oils (Jatropha and palm oils) to substitute the use of mineral-based oil. The present work focuses on the performance of refined bio-based metalworking fluids during tapping torque and orthogonal cutting processes. Bio-based metalworking fluids were formulated using 0.05 wt.% of hexagonal boron nitride (hBN) and 1 wt.% of phosphonium-based ionic liquid [P66614][(iC8)2PO2] in a modified Jatropha and palm olein oils and were examined for their rheological properties in comparison with a commercially obtained synthetic ester (SE)-based cutting fluid. The tapping torque performance of the refined bio-based metalworking fluids was evaluated for their torque and efficiency. In addition, the performance of these bio-based metalworking fluids on orthogonal cutting parameters such as cutting force, cutting temperature, chip thickness, tool-chip contact length, and specific cutting energy was highlighted. The results obtained revealed that the rheological properties of the newly formulated bio-based metalworking fluids were improved. From the tapping torque and orthogonal cutting performances, it was proven that the modified palm and Jatropha oils possess good anti-wear and anti-friction behavior compared to SE. In conclusion, the newly formulated bio-based metalworking fluids are suitable for the use as a new advanced renewable metalworking fluid for machining processes that correspond to the energy-saving benefits and environmental concerns.",signatures:"Erween Abd. Rahim, Amiril Sahab Abdul Sani and Norfazillah Talib",downloadPdfUrl:"/chapter/pdf-download/58266",previewPdfUrl:"/chapter/pdf-preview/58266",authors:[{id:"174050",title:"Associate Prof.",name:"Erween",surname:"Abd Rahim",slug:"erween-abd-rahim",fullName:"Erween Abd Rahim"},{id:"214205",title:"M.Sc.",name:"Amiril Sahab",surname:"Abdul Sani",slug:"amiril-sahab-abdul-sani",fullName:"Amiril Sahab Abdul Sani"},{id:"214206",title:"Ms.",name:"Norfazillah",surname:"Talib",slug:"norfazillah-talib",fullName:"Norfazillah Talib"}],corrections:null},{id:"58961",title:"Evaluation of the Biotribological Behavior and Cytotoxicity of Laser-Textured ISO 5832-1 Stainless Steel for Use in Orthopedic Implants",doi:"10.5772/intechopen.73140",slug:"evaluation-of-the-biotribological-behavior-and-cytotoxicity-of-laser-textured-iso-5832-1-stainless-s",totalDownloads:865,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter evaluated the influence of laser texturing process on the tribological behavior of the ISO 5832-1 austenitic stainless steel (SS). The friction coefficient and wear were determined using ball-cratering wear tests. The laser texturing process was carried out with a nanosecond optical fiber ytterbium laser at four different pulse frequencies. Cytotoxicity tests were carried out to determine if laser texturing affects the biomaterial biocompatibility. For comparison reasons, pristine surfaces were also evaluated. The results indicated that the wear volume and friction coefficient were reduced after laser texturing. The samples were considered noncytotoxic according to the biocompatibility tests as the laser texturing process did not decrease cell’s viability.",signatures:"Eurico Felix Pieretti, Andrea Cecília Dorión Rodas, Renato Altobelli\nAntunes and Maurício David Martins das Neves",downloadPdfUrl:"/chapter/pdf-download/58961",previewPdfUrl:"/chapter/pdf-preview/58961",authors:[{id:"98553",title:"Dr.",name:"Renato",surname:"Antunes",slug:"renato-antunes",fullName:"Renato Antunes"},{id:"218783",title:"Dr.",name:"Eurico",surname:"Pieretti",slug:"eurico-pieretti",fullName:"Eurico Pieretti"},{id:"222968",title:"Dr.",name:"Andrea Cecilia Dorion",surname:"Rodas",slug:"andrea-cecilia-dorion-rodas",fullName:"Andrea Cecilia Dorion Rodas"},{id:"222974",title:"Dr.",name:"Maurício David Martins",surname:"Neves",slug:"mauricio-david-martins-neves",fullName:"Maurício David Martins Neves"}],corrections:null},{id:"58898",title:"Surface Morphology and Tribological Properties of Nanoscale (Ti, Al, Si, C)N Multilayer Coatings Deposited by Reactive Magnetron Sputtering",doi:"10.5772/intechopen.73141",slug:"surface-morphology-and-tribological-properties-of-nanoscale-ti-al-si-c-n-multilayer-coatings-deposit",totalDownloads:888,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The current topics related to the morphology and tribology of TiAlN monolayer, TiAlN/SiNx, TiAlN/CNx and TiAlN/CNx±CNx nanoscale multilayer coatings and refer to our recent results on the evaluation of surface morphology, and nanoscale mechanical and tribological properties of coatings deposited on cemented carbide cutting tools and silicon wafer substrates by reactive magnetron sputtering deposition. The surface morphology and microstructure of the coatings were evaluated with an atomic force microscope in dynamic friction mode together with transmission electron microscope imaging. The tribological properties of the coatings were evaluated by pin-on-disc friction testing in dry air, and high-frequency linear-oscillation friction testing under various lubrication conditions. The tribological properties of the multilayer TiAlCrSiN and TiAlSiN coatings were compared with those of a single layer TiAlN coating to evaluate their possible applications to the surfaces of cutting tools. The machining performances of single layer TiAlN, multilayer TiAlSiN, and TiAlCrSiN coated drills were investigated in drilling of carbon steel.",signatures:"Mei Wang and Shojiro Miyake",downloadPdfUrl:"/chapter/pdf-download/58898",previewPdfUrl:"/chapter/pdf-preview/58898",authors:[{id:"22097",title:"Dr.",name:"Mei",surname:"Wang",slug:"mei-wang",fullName:"Mei Wang"},{id:"221806",title:"Prof.",name:"Shojiro",surname:"Miyake",slug:"shojiro-miyake",fullName:"Shojiro Miyake"}],corrections:null},{id:"60196",title:"Effects of Different Materials on the Tribological Performance of PVD TiN Films under Starved Lubrication Regime",doi:"10.5772/intechopen.75842",slug:"effects-of-different-materials-on-the-tribological-performance-of-pvd-tin-films-under-starved-lubric",totalDownloads:911,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Grit blasting is one simple but effective method to modify the morphology of material surface and can improve the tribological performance. In this study, a thick TiN film was prepared by arc ion plating on the steel disk treated with grit blasting, and the rough surface coated solid film was obtained. The tribological properties of solid film against different materials were evaluated under starved lubrication regime. The results showed that the friction coefficients of rough titanium nitride (TiN) films were lower than those of rough steel disks exclude alumina ball under starved lubrication, and the wear rates of TiN film were negligible due to the high hardness of TiN film and small contact area. For four kinds of balls including steel ball, silicon nitride, zirconia, and alumina, the wear scar diameter of steel ball is biggest, and the wear scar diameters of other balls are small. The hardness of steel ball is less than others, which results in the easy abrasion and increases the contact area to reduce the pressure. So the friction coefficient of TiN against steel is low and steady.",signatures:"Dong Jiang, Xiaoming Gao, Ming Hu, Desheng Wang, Yanlong Fu,\nJiayi Sun and Lijun Weng",downloadPdfUrl:"/chapter/pdf-download/60196",previewPdfUrl:"/chapter/pdf-preview/60196",authors:[{id:"227649",title:"Associate Prof.",name:"Dong",surname:"Jiang",slug:"dong-jiang",fullName:"Dong Jiang"},{id:"239552",title:"Dr.",name:"Xiaoming",surname:"Gao",slug:"xiaoming-gao",fullName:"Xiaoming Gao"},{id:"239553",title:"Dr.",name:"Ming",surname:"Hu",slug:"ming-hu",fullName:"Ming Hu"},{id:"239554",title:"Dr.",name:"Desheng",surname:"Wang",slug:"desheng-wang",fullName:"Desheng Wang"},{id:"239557",title:"Dr.",name:"Yanlong",surname:"Fu",slug:"yanlong-fu",fullName:"Yanlong Fu"},{id:"239559",title:"Dr.",name:"Jiayi",surname:"Sun",slug:"jiayi-sun",fullName:"Jiayi Sun"},{id:"239563",title:"Dr.",name:"Lijun",surname:"Weng",slug:"lijun-weng",fullName:"Lijun Weng"}],corrections:null},{id:"58150",title:"Lubrication and Friction of Porous Oil Bearing Materials",doi:"10.5772/intechopen.72620",slug:"lubrication-and-friction-of-porous-oil-bearing-materials",totalDownloads:896,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In order to address poor lubrication of porous bearings due to the seepage flow of oil into the porous medium, multi-layered sintered composite bearings have been developed. Multi-layered bearings achieve a combination of high strength and good lubrication. Lubrication model of the porous multi-layer materials in polar coordinates was established based on Darcy’s law. And the effect of surface Darcy flow and porous structure on the lubrication capacity were discussed by using the finite difference method. In the end, the tribology experiments of the multi-layer materials were presented on the end face tribo-tester to verify the simulation results. Results show that the lubrication performance of the multi-layer materials is better than that of the single layer materials. With the decrease of the surface porosity, the lubrication performance becomes better in the given range of surface layer. Also, it can be significantly improved if considering the surface Darcy flow. Within a certain range, the effects of surface Darcy flow on lubrication performance are more obviously with higher speed. There is a good agreement between the numerical analysis and the measurement. Research work provides a theoretical basis for analysis and design of multi-layer sintering bearing material.",signatures:"Yanguo Yin and Guotao Zhang",downloadPdfUrl:"/chapter/pdf-download/58150",previewPdfUrl:"/chapter/pdf-preview/58150",authors:[{id:"213072",title:"Prof.",name:"Yanguo",surname:"Yin",slug:"yanguo-yin",fullName:"Yanguo Yin"},{id:"213417",title:"Dr.",name:"Guotao",surname:"Zhang",slug:"guotao-zhang",fullName:"Guotao Zhang"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3128",title:"Tribology",subtitle:"Fundamentals and Advancements",isOpenForSubmission:!1,hash:"77f3ee5568b737c8d26a5eee991c9d34",slug:"tribology-fundamentals-and-advancements",bookSignature:"Jürgen Gegner",coverURL:"https://cdn.intechopen.com/books/images_new/3128.jpg",editedByType:"Edited 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Before cultured cells were available, the main objects of cell physiology were nerve and blood cells. The study of giant axons showed that excitability and irritability are the most important properties of living cells. Russian physiologist E. Bauer used these properties to affirm the principle of “stable nonequilibrium” [1]. This principle explains that in the changing environment, living systems maintain their structural stability through energy supply. Instead of “energy,” however, he uses the term “work” performed by system against equilibrium. Physiological implication of this principle was found upon the study of nonequal redistribution of Na+ and K+ ions in cuttlefish neuron during impulse propagation [2].
Physiological studies of living cells are always done in conjunction with light microscopy methods. Later these methods got resolution sufficient to study cell structures in molecular scale. The maximum resolution that allows observation of hexagonal pattern on diatom algae is reached in basic microscopy by shutting the condenser [3]. Near-field scanning optical microscopy (NSOM) overcomes the diffraction limit by using optical fiber for both illumination and scanning [4]. NSOM was able to visualize small antibody-labeled domains on the plasma membrane of living human skin fibroblasts [5]. The small thickness of these cells uses conventional epi-fluorescence microscopy to study the mitochondrial membrane potential (MMP) [6, 7] using the protocol of automated image analysis of mitochondrial shape originally tested by confocal microscopy [8, 9]. The same functionality but greater performance resides in the method of imaging flow cytometry. The method allows fluorescence quantification using spot masks that are created independently on pixel intensity. This method was applied for the characterization of MMP changes involved in the malignant transformation of cancer stem cells. MMP together with such parameters as glucose uptake, superoxide-anion production, and mitochondria mass served as indicator of tumorigenesis [10].
Besides using CCD camera in conventional fluorescence microscopy, video microscopy suggests built-in image processing algorithms that cause inadvertent effect on pixel intensity, but with additional calibration procedure, absolute intensities are also measurable [11]. Instead of these algorithms, conventional microscopy uses deconvolution to improve the quality of images as in confocal microscopy [12]. For example, deconvolution was applied to wide-field microscopy images to resolve DNA replication units that are studied only by electron and structured illumination microscopy [13]. Unlike these later methods, confocal and classical light microscopy possesses the ability to study these structures in the living cells.
Discrimination of depth is a property of confocal microscopy that relies to confocal diaphragm [14] and can be checked by measuring the point spread function (PSF), which is defined as the image of a single point [15]. To see the changes on the image of real object, which contains convoluted PSFs, is impossible unless deconvolution is applied [12]. Special image processing algorithm is also applied in confocal microscopy for quantitative fluorescence analysis. This algorithm was applied in quantitative studies of mitochondrial [Na+] ([Na+]m) and Ca2+ ([Ca2+]m) and mitochondrial pH (pHm) in MDCK cells stained with one of the ion-sensitive dyes [16, 17, 18]. Obtaining information about cellular organelles such as mitochondria requires creation of mask.
The same analytical approach was applied for the study of MMP changes caused by phytohemagglutinin (PHA) treatment in histiocytic lymphoma U937 cells. The image of TMRE-stained cells was used for both creating the mask and obtaining quantitative data. The value of average intensity obtained from masked image is independent of the wide variation of MMP. Therefore, this image can serve as a measure of MMP. To consider the effect of large mitochondrial depolarization that occurs in cells after PHA treatment, data were presented as integrated density divided by the number of cells on the image.
PHA is a lectin that stimulates growth and division of lymphocytes in the process known as transformation [19]. Previous studies using indirect isotopic method have not found considerable MMP change during mitogenic stimulation [20]. At the same time, lectins are affecting all known metabolic pathways. Early response in lymphocytes to PHA treatment includes stimulation of glycolysis [21], activation of pentose-phosphate cycle [22], and activation of pyruvate dehydrogenase (PDH) [23] that is a key enzyme to connecting glycolysis and citric acid cycle.
The history of CLSM began when Marvin Minsky include in his patent letter the scheme with epi-illumination with two pinholes that play the same role as in “double focusing” scheme which have already been tested with a stage-scanning device [24]. Historical information and many technical details are not covered in the present paper but can be found in an encyclopedia article written by Amos and colleagues [14]. From a biological point of view, the development of CLSM began in 1987 when microscopes with laser beam deflection system were able to scan living kidney epithelium cells [25] and spinal cord neurons [26].
The development of CLSM ranging from 1987 to 1995 is distinctive by exponential rise of citations for the query “microscopy AND confocal” (Figure 1). At this period, the number of studies retrieved by the query “microscopy NOT confocal” shows a rather decelerating trend. In 1995, the number of confocal microscopy studies started to grow linearly, while many microscopic studies remain unpublished. The second period ended with the new millennium when linear trend of CLSM publications was accompanied by extensive growth of other microscopic studies. The third period is therefore noticeable by concomitant development of all microscopic methods. During this period, confocal microscopy constitutes one sixth of microscopic papers. Indeed, this share would be greater if query is restricted only to cytological area. It can be concluded that the first period caused a 10-year delay in the development of other microscopical methods, while the second period caused its rapid growth.
Relation between the studies done by confocal or other microscopical methods from 1972 to 2018 following the records from PubMed. Trends of publications by year were downloaded from PubMed web page [
Ideal confocal microscope has detector pinhole that is small enough to suppress the diffraction in emission light path. This made its resolution equally dependent from excitation and emission light paths [14]. Lateral resolution of real confocal microscope is determined by the illuminating pinhole that participates in the formation of PSF [15]. Therefore, lateral resolution of confocal microscope is given by formula
where FWHM is the distance between the points on distribution where its intensity is half of that of the peak intensity,
In real confocal microscope, the detector pinhole determines its axial resolution. The difference in axial resolution between confocal and conventional microscopy can be demonstrated using thin fluorescent sheet. By switching microscope to epi-fluorescent mode, no changes in fluorescence intensity are observed upon moving the test object out of focus. Back to the confocal microscopy mode, fluorescence intensity will decrease in sigmoid manner, the slope of which will depend on pinhole diameter [14]. Thickness of optical section is then given by the formula
where n is the refractive index of immersion medium (
In the current study, we use a step-function fluorescent object for testing the limits of axial resolution of CLSM. The test object was prepared as described in [14] but with the following modifications. Fluoroshield™ mounting media containing 20 μg/ml rhodamine 6G was placed between a microscopic slide and 24 mm squire coverslip and left under 1 kg weight until drying. Fluorescence intensity profiles were obtained by scanning fluorescent object in X,Z direction at different pinhole sizes. As shown in Figure 2A, an increase of pinhole diameter from 1.05 to 3.0 Airy widens fluorescence intensity profile and fluorescence background. Taking the advantage of normal distribution of fluorescence values, we use Gauss function for obtaining FWHM values of intensity curves. The effect of pinhole diameter ranging from 0.45 to 4 Airy units on profile width is presented in Figure 2B.
Effect of pinhole diameter on the width of fluorescence profile recorded across a layer of Fluoroshield™ media containing 20 μg/ml rhodamine G. (A) Fluorescent intensity profiles of X,Z optical sections are registered by Olympus FV3000 confocal microscope equipped with 60x/1.42 plan apochromat objective. Fluorescence was excited at 488 nm and collected from 500 to 600 nm. Two fluorescent profiles obtained at pinhole diameters of 210 and 600 μm (corresponding to 1.05 and 3 Airy units) are shown. One curve is the mean of seven plots generated using ImageJ program. Fluorescence intensity is kept constant by adjustment of laser power. (B) FWHM is derived from the intensity profiles obtained at pinhole diameters of 0.45, 0.65, 0.8, 1.05, 3, and 4 Airy units.
Changes of profile width are correlated with the changes in the optical thickness upon variation of pinhole diameter up to the 3 Airy units. Namely, changing of the pinhole diameter from 1.05 to 3 Airy units increases the width of intensity profile by 0.6 μm. Changing pinhole in reverse order, from 1.05 to 0.65 Airy units, decreases the width of intensity profile by 0.1 μm (Figure 2B).
The absolute resolution values are usually different from those predicted by Eqs. (1) and (2). Practically it is determined by the measurement of PSF, which is generated by microspheres with a diameter of 170 nm in lateral and axial planes. In one practical study, FWHM was determined as 0.32 and 1.9 μm in X,Y or X,Z directions, respectively [18]. The high value of axial FWHM depth is explained by the necessary use of high pinhole diameter in a study of mitochondrial pH in MDCK cells. Pinhole diameter of about three Airy units was applied in this study to attenuate laser power and minimize its photo-damaging effect on living cells [18, 28].
The resolution of CLSM in large extent depends on the quality of objective lens. Using the correct objective in CLSM is especially important because lens parameters are assumed in the design of particular confocal system. Choosing lens with the same nominal parameters but designed for other microscopes results in more than twice a decrease of resolution [29]. In addition, high-magnification oil-immersion objectives work correctly in media with the refractive index being very close to the refractive index of living cells. Any mismatch of the refractive index decreases the quantity of excited fluorescence and, therefore, resolution of confocal system. Water immersion objectives allow working with deeply lying cells [30].
Earlier confocal systems have difficulties in using multiple dyes. Therefore, studies were done in parallel samples assuming that experimental conditions equally apply for both dyes. SNARF-1 (seminaphtorhodafluor-1, free form) was used for the study of pH of luminal solution along colon crypt. Using CLSM localization SNARF-1 was compared with the localization of dye Lucifer yellow [30]. Pseudo-ratiometric approach utilizes cells stained simultaneously with two dyes localized in the same cellular compartment. MitoTracker Green (MTG) resides in the mitochondria and therefore can be colocalized with the dye of interest [16, 17, 18]. As the latter were used one of the following dyes, Rhod-2 (AM), CoroNa Red, or SNARF-1 (AM), accumulated in the mitochondria and giving information on cytoplasmic concentrations of [Na+]m, [Ca2+]m, and pHm, respectively. By using Fura-2 (AM), it was shown that during metabolic inhibition, the main source for transient increase in cytoplasmic Ca2+ concentration ([Ca2+]c) is the mitochondria [16], and only functionally active mitochondria can have buffering capacity to Ca2+ [31].
A large number of studies are directed to understand mitochondrial heterogeneity, which is manifested as the differences in shape and size of the mitochondria in a single cell [8, 9] or morphological differences between cell types [32]. Some cell mitochondria appear as network but in others as discrete individuals [32]. Fission and fusion that maintain the dynamic structure of mitochondrial network are mechanisms involved in the regulation of cell proliferation and apoptosis [33]. These processes are sensitive to cell metabolic state and MMP. Elongated mitochondria are dominant in mouse embryonic fibroblasts grown in conditions promoting oxidative phosphorylation. The addition of glucose suppresses elongation and causes fragmentation [34]. In the study, reviewed in the next section, the attempt was made to uncover the dynamic nature of MMP changes and its role in maintaining mitochondrial network structure.
In studies of MMP, it is important to consider the thickness of optical section because it determines the affectivity of detection of mitochondrial fluorescence. FWHM of optical section that is calculated by Eq. (2) is almost fit to the dimensions of the mitochondria in U937 cells. Electron microscopic studies follow that the mitochondria in U937 cells are spheroidal in structures with a diameter of 0.6–0.8 μm [35]. Therefore, CLSM is effectively collecting fluorescence from the mitochondria of TMRE-stained U937 cells. The mitochondria in lymphocytes have a diameter of only 0.3–0.4 μm [19, 36, 37], and the affectivity of collection of mitochondrial fluorescent signal is less than U937 cells. The mitochondrial shape is also considered in choosing the right procedure for image processing. Thus, different procedures are required for the study of mitochondria in U937 cells or in skin fibroblasts having threadlike appearance [38].
Using CLSM in the study of MMP, it is possible to select for analysis the whole cell area. This selection includes nonmitochondrial compartment that constitutes about 95–98% of the total cell volume [10, 20]. Its signal can be set as a background and subtracted from total fluorescence. The example of this approach is found in a study of MMP changes in lamprey hepatocytes during prespawning migration. As can be expected, CLSM gave results similar to that of flow cytometry [39]. The reason why this approach is chosen by authors is the absence of parallel control samples that are necessary for analytical procedures involving image processing.
Another simplified approach is based on staining of cells with TMRE and MTG and using MTG as reference. For example, TMRE/MTG fluorescence ratio was decreased in the muscle cells of zebrafish embryo after chronical treatment by rotenone [40]. The utilization of MTG as reference dye however is limited because its uptakes in some types of cells depend on MMP [41]. Therefore, MTG is generally used for the creation of mask [16, 17, 18]. By combination of these approaches, it was shown that both TMRE/MTG ratio and MTG signal increased during malignant transformation of mesenchymal stem cells [10].
Good substitute for MTG is mitochondria-specific green fluorescence proteins (GFP). MitoAcGFP1 located in mitochondrial matrix was used for the study of mitochondrial [Ca2+]m [6]. Photoactivatable GFP was used for tracking individual mitochondria in order to relate their MMP to fission events [42, 43]. Data obtained in later studies lead authors to the conclusion that depolarization triggers fission of the mitochondria and fission serves as the quality control for its functional properties [43]. However, the applicability of GFP is limited by insufficient level of expression in some cell types [32, 42]. Rhodamine ester dyes were also used as reference dye in the study of [Ca2+]m [31]. Evidence was provided that TMRM (tetramethylrhodamine, methyl ester) is not liable to auto-quenching and therefore suitable both for the creation of mask and determination of MMP [6]. This is especially important because data obtained using dye rhodamine 123 do not allow their interpretation in terms of MMP.
CLSM experiments with living cells are preceded by cell staining. During staining, TMRE dye almost completely uptakes the cells; hence, it is important to keep constant the dye-to-cell ratio. This ratio should also be equal in control and treated cells. During image acquisition it is possible to use previously saved settings. The function of “auto-exposure” can be used only once with living cells at the beginning of the study [44]. The reason for this is to keep cells from overexposure from laser irradiation. The optimum settings however allow keeping the dynamic range of detector maximum and preventing most of the pixel on image from saturation. Fluorescence intensity is almost linearly dependent on laser power and nearly exponentially—on voltage of photomultiplier tube (PMT). Therefore, it is generally recommended to set PMT voltage first and then adjust laser excitation intensity [44]. With calibration, PMT voltage also can be varied and used for adjustment [18, 28].
Examples of image processing that can be found in the earliest studies are threshold, gradient filtering, and segmentation. These procedures are applied to images resulted from summing of intensity along the Z-axis [26]. Graphical filters are specific instruments used to eliminate noise or other unwanted information from image. “Rolling ball” algorithm uses rank operators to remove pixels exceeding the local background level and replaces them with pixels of neighborhood intensity. The processed image is then subtracted from the original image [45]. “Top hat” filter is used for processing such complex structures as mitochondrial network in human skin fibroblast [8, 9]. “Rolling ball” filter is suitable for images of U937 cells containing the mitochondria of elliptical shape.
For demonstration of image processing in our study, U937 cells were treated with PHA (30 μg/ml, 2 h) and stained with 25 nM of TMRE dye. Cell suspension was placed in Plexiglas holder and scanned in the middle plane of the most cells. Histogram equalization was used to check the amount of TMRE in nonmitochondrial compartment. This was done by running command “enhance contrast” in ImageJ program. Apart from the mitochondria and cytoplasm, small fluorescence is present in the nucleus (Figure 3A and B). To remove background fluorescence, images were processed by “subtract background” algorithm in ImageJ program that utilizes “rolling ball” operator [46]. On the next step, the processed image is subjected to thresholding, which is used to suppress variations at the background level [45]. ImageJ program allows obtaining quantitative data after setting a threshold and execution of commands “create selection” and “analyze stack.” However, for demonstration of validity of this procedure, binary mask (mask) was applied to histogram-equalized image (HEQ) rather than to original image (RAW). This operation gives possibility to see variations within regions, which appeared uniform in the original image [45]. The procedure of histogram equalization is similar to the linear contrast stretch used in other works [6]. The resulting masked images (MSK) contain nonzero pixels that correspond to mitochondrial compartment (Figure 3B and E). Histogram equalization emphasizes mitochondrial heterogeneity and proves the absence of fluorescence in cytoplasmic compartment. However, HEQ images do not give possibility to see the difference of intensities between control- and PHA-treated cells because changes of intensity caused by this procedure are specific to each image [45].
Demonstration of using image processing for quantitative study of MMP changes in U-937 cell during PHA treatment. Cells were incubated without (A–C) or with p-PHA (30 μg/ml) for 2 h (D–F) in atmosphere of 5% CO2 and stained with 25 nM TMRE for 30 min at 37°C. Excess of media was removed by centrifugation. 20 μl of cell suspension is placed on coverslip and a 1% gelatin solution is attached to Plexiglas holder sealed from another side with coverslip. Fluorescence was excited by 561 nm diode laser and collected at 575–675 nm through pinhole of 178 mm (0.73 Airy units). (A, D), raw images after histogram equalization (EQH); (B, E), masked version of this images (MSK); (C, F), merged images of MSK (red pseudo-color), and EQH (green pseudo-color). Red pixels colocalized with green pixels in an area of high intensity except the blurred regions that are present in some cells. Arrows indicate small aggregates of agglutinated cells.
Using merged images it is possible to see similarity between MSK and nonzero regions of HEQ image. As it can be seen in Figure 3C and F, colocalization is present in all regions except blurred parts that are present in both control- and PHA-treated cells. Good correlation between MSK and HEQ is also seen by “Color inspector 3D” plug-in in ImageJ program. The presence of cell groups that mark the beginning of agglutination process was noticed on the image of PHA-treated cells (Figure 3F, arrows). At this period, however, agglutinated cells are lying in plane of imaging available for study.
For quantitative analysis of MMP changes, two analytical values were used. Average intensity is a measure of absolute MMP, but it underestimates changes of MMP if they occur below the threshold level (Figure 4A). The relative value is obtained by the division of integrated density to cell number considering the presence of cells with completely depolarized MMP. This value is applied more specifically and therefore was named “mean cell fluorescence” (Figure 4B). The decrease of average intensity caused by PHA treatment is lower than the corresponding decrease of mean cell fluorescence by 5%. This dissimilarity shows the presence of cells whose fluorescence changed below the detection limit. The changes in the selection area are calculated as the total selection area on images divided by the number of cells attributing to these fluorescent images (Figure 4C).
Quantification of MMP changes in U937 cells during PHA treatment (30 μg/ml, 2 h). (A–C) quantitative data retrieved from images acquired in one (B, C) and three (A) experiments. Data are expressed as means ±SD. The number of images that is used in the analysis is shown near each bar. (A) Average TMRE fluorescence intensity found in selection area. (B) Mean cell fluorescence calculated as integrated density divided by the number of cells. (C) Mean area of selection calculated as total selection area divided by the number of cells. (D) Protocol of imaging processing and analysis. Most important operations are shown by arrows, while its results are indicated in boxes: RAW, original image; EQH, original image after histogram equalization; BS and BIN, images after running “subtracted background” and “threshold” commands, respectively; mask, mask image; MSK, image obtained by multiplying EQH image by mask image. Dot lines show the operations used for the creation of masked image (MSK).
The relation between these analytical options can be understood from the schematic representation of full analytical process shown in Figure 4D. It started from original image (RAW), the duplicate of which passes three steps until it resulted in the generation of mask or the selection of congruent regions on RAW image with output of numerical results. Histogram equalization, background subtraction, and thresholding were done similarly to those published in earlier works [6, 28]. The method presented in Figure 4D also gives possibility to control mitochondrial selection area and compare it with already known morphological data. From the data presented in Figure 4C and from known value of cell area (120 μm2), it can be concluded that selected area constitutes about 10% of cell area. This is close, for example, to a value of 8% in tumorigenic cell lines obtained by electron-microscopic examination [10].
The decrease of average fluorescence intensity by 34% after 2 h of PHA treatment is attributed to the changes of absolute MMP value. While our data were obtained on the early stage of stimulation, they can be correlated with data on metabolic shift that occurs in lymphoid cells after prolonged treatment. These data suggest that the role of the mitochondria in total energy balance decreases during stimulation. It was shown that glycolytic activity in lymphocytes increases by 36 times but the respiratory activity is only by 43% [21]. In thymocytes that obtain energy mainly by glucose oxidation, lectin treatment leads to the deceleration of this pathway [47]. On the contrary, in mesenchymal stem cell, mitochondrial activity is increased during malignant transformation [10].
The difference in selection area between control- and PHA-treated cells (Figure 4C) suggests that MMP in some cells is completely lost. These changes could be related to the changes of [Ca2+]c because it is known that [Ca2+]c is increased after mitogenic stimulation [48]. The mitochondria play essential role in the regulation of [Ca2+]c [31, 49]. During metabolic inhibition in MDCK cells, [Ca2+]c is transiently increased. Restoration of normal [Ca2+]c occurs by coupled action mitochondrial Na+/Ca2+ and Na+/H+ exchangers. Metabolic inhibition decreases proton gradient on mitochondrial membrane [18] and reduces outward Na+ and Ca2+ movement mediated by these transporters. As a consequence, Na+ and Ca2+ concentration in mitochondrial matrix is steadily increased [16, 17].
Similar situation may exist in stimulated lymphoid cells where the magnitude of proton electrochemical gradient is compromised by the changes of pHc. The Na+ content in lymphocytes is increased rapidly after PHA treatment with maximum of 2 h [50]. Both K+ content and influx are also increased during mitogenic stimulation [50]. Therefore, the increase of cytoplasmic [Na+] ([Na+]c) in response to lectin treatment is mediated by Na+/H+ exchanger. This view agrees with the increase of pHc in both thymocytes and lymphocytes after lectin treatment [51, 52]. To test whether these changes take place in U937 cells during PHA stimulation, we performed investigation of [Na+]c by Na-sensitive dye Asante Natrium Green-2 (ANG). As followed from the flow cytometric data, the fluorescence of ANG was increased after 1 h of PHA treatment (Figure 5). The mean ANG fluorescence increased by PHA treatment from 1.89E+05 to 2.59E+05 relative units. Assuming that changes of fluorescence are proportional to the changes of concentration, [Na+]c will increase from 30 mM in resting U937 cells to 38 mM upon PHA treatment.
Effect of PHA treatment (30 μg/ml, 1 h) on fluorescence of ANG dye. Cells stained with ANG-AM (1 μM) during the last 40 min of PHA treatment (37°C). ANG fluorescence was excited using a 488 nm laser, and emission was detected in the FITC channel with a 525/40 nm bandpass. Data were analyzed using CytExpert 2.0 Beckman Coulter software. The major cell populations were selected for analysis using forward/side scatter plot. Data were obtained using the same samples as data presented in
The demonstrated increase of [Na+]c in PHA-stimulated U937 cells may be considered as part of the regulatory mechanism involved in the increase of [Ca2+]m. The increase of [Ca2+]m in many cell types causes activation of mitochondrial dehydrogenases [49] and accounts for the rapid activation of mitochondrial PDH in response to lectin action [23, 53]. The increase of [Ca2+]m can also lead to mitochondrial injury that was confirmed by serious ultra-structural changes observed in human lymphocytes after 3 days of lectin treatment [36, 54]. The deleterious effect of lectins on mitochondrial morphology, however, was absent in other experiments [19, 37, 54]. Controversy of results obtained in these studies can be explained by the complexity of regulatory mechanisms controlling mitochondrial Ca2+ and Na+ homeostasis. This reason can also be applied in our study in which a large variation in the number of cells with complete mitochondrial depolarization was noticed.
The role of the mitochondria in energy supply is determined by the functional state of the cells. This problem is usually addressed by biochemical, polarographic and optical methods which measure ATP production and oxygen consumption in the living cell. In many studies, it is also corroborated by parallel measurement of mitochondrial membrane potential (MMP). This article describes fluorescent method of measuring MMP in cancer cell using potential-sensitive dye TMRE. This method can distinguish fluorescence of TMRE in mitochondrial and nonmitochondrial compartment by using standard software for image analysis.
I acknowledge TS Goryachaya for maintaining a cell culture and ND Aksenov for assistance with flow cytometry investigations. I am very grateful to JP Battersby for discussions leading to the current study and to GI Shtein for technical consultations. I am also thankful to Prof. VS Saakov for his help in the writing of this manuscript.
Fenugreek (
The main secondary metabolites and seed contents of fenugreek were given in Figure 1 [2, 3, 4].
Main secondary metabolites and seed context of fenugreek.
Polyphenol compounds
A wide range of beneficial effects of fenugreek seeds has been reported by a number of researchers. In addition to antidiabetic effects, seeds have significant antiatherosclerotic [7], anti-inflammatory [8], antinociceptive [9], and antiulcerogenic activities [10] which are essential for cure of diabetes and cancer disease. Antioxidant property helps in anti-aging. The phenolic antioxidants present in the extract of fenugreek show free radical scavenging activity which reduce oxidative stress in the body. This reduced oxidative stress reduces frequency of age-related disorders [11].
It was reported that fenugreek seeds had low amount essential oil and fatty oil [12]. According to the essential oil compounds findings; olfactometry diacetyl, 1-Octen-3-one, sotolone, acetic acid; 3-Isobutyl-2-methoxypyrazine, butanoic acid, isovaleric acid, 3-isopropyl2-methoxypyrazine, caproic acid, eugenol, 3-Amino-4,5-dimethyl-3, linalool, (Z)-1,5-Octadiene-3-one, 4-dihydro-2(5H)-furanone were determined as the main components [13]. It has been noted that sotolone is mostly found in fenugreek (5 s)-enantiomeric form (95%) among these essential oil components.
A study on human sweat was conducted by Meghwal and Goswami [3] and regarding essential oil components; pinene,3-octen-2-one, 2,5-dimethylpyrazine, b-camphor; terpinen-4-ol, 4-isopropylbenzaldehyde were found as the odor in sweat, while neryl acetate and b-caryophylene, 2,5-dimethylpyrazine has been observed to be the main component responsible for the compound contributing to sweat odor.
Many studies have been conducted on the therapeutic applications of various plant species on different diseases such as fungal, viral and bacterial contamination. Therefore, approximately one third of the world’s population uses traditional/therapeutic plants and their extracts in their treatments [14]. A drug with both antidiabetic and antioxidant activity is much more beneficial in the treatment of diabetes. In addition, herbal medicines are more preferred due to the undesirable side effects of the existing antidiabetic medicine. As can be seen from the above explanations, fenugreek has the potential to be a versatile herbal medicine. Therefore, further studies are needed to provide detailed information about the effects of fenugreek. So, in this review, it was aimed to inform about the studies conducted with the effects of fenugreek.
Generally, this study revealed the importance of focusing on the antioxidant, hypoglycemic, hypercholesterolemia, anticancer, antibacterial and antifungal properties, as well as on its medicinal properties, phytochemical and nutrient contents. In case, fenugreek is grown for bioactive secondary metabolites, concentrating on different activities such as polyphenol compounds, anti-inflammatory, antimicrobial properties.
Fenugreek has been used in traditional cure treatments dates back to the 15th century. Different parts of fenugreek such as seeds and leaves were used to treatment of symptoms and ailments. For instance, a paste prepared with ground fenugreek seeds was used to treat eczema, local inflammations of the skin-as locally administered poultice or added to a hot bath [15].
Fenugreek is easily grown all over the world because of its wide adaptation and its usage varies significantly between countries.
Many studies were conducted to determine and confirm the traditional uses of fenugreek as herbal cure using different plant part (seeds and leaves) or pure phytochemicals (saponins, steroids, alkaloids). Fenugreek seeds have been reported to have an aphrodisiac effect in ancient times, but modern vaidyas have used it more for digestive and respiratory problems caused by phlegm and wind. In ancient Egypt, it was recorded that methi (fenugreek) was used to facilitate childbirth and increase milk flow, and modern Egyptian women still use fenugreek to make hilba tea to relieve menstrual cramps and relieve other abdominal pains. The Chinese call it hu lu ba and also use it to treat abdominal pain. While the fresh stems and leaves are mostly used as a winter vegetable, seeds are used as a flavor agent in different foods in India [16].
The seeds are also eaten raw as sprouts and used medicinally. While fenugreek is used in baking bread by Egyptian and Ethiopian, Switzerland uses it to flavor cheese. In the USA, it is mostly used in spice mixes for soups and stews [16]. Fenugreek has been used as a spice in cooking for centuries in European countries and remains a popular ingredient in curry powders, pickles, and spice mixes in India, Pakistan, Bangladesh, and other Asian countries. Fenugreek has been used in folk remedies to treat cellulite, boils and tuberculosis. Fenugreek remained a key ingredient in a 19th century patented drug for dysmenorrheal and post-menopausal symptoms [17].
Fenugreek was also used for ethnoveterinary applications such as the decrease of serum cholesterol in animals [18] and the increase of milk production in animals [19].
In the Ayurvedic and Unani systems of medicine, fenugreek is used to cure epilepsy, paralysis, gout, dropsy, chronic cough and piles. This crop has also known as potential of oleoresin and steroid production for oral contraceptives. In addition, ground seeds use as a control mechanism for the blood sugar and thereby checks the diabetes in human beings [20].
Fenugreek leaves are widely used for treatment of eye diseases in Iran [21] and gynecological disorders [22]. In traditional medicine, it is used to prepare infusions, water and alcohol extracts, tinctures, honeys, tonics with antidepressant and psychotonic properties, and muscle growth supplements. It is also used in the treatment of seborrhea, acne and dermatitis. The plant is widely used in cosmetology [23]. It was reported that fenugreek seeds have been used as an oral insulin substitute to decreasing blood sugar [17].
The aroma and taste of fenugreek has led to its use in imitation maple syrup [24]. Furthermore, fresh and dried leaves are used as vegetables in the diets. It was found that these leaves included calcium; zinc iron, phosphorous, riboflavin, carotene, thiamine, niacin and vitamin C. The leaves of fenugreek, which are stored in either in refrigeration conditions or dried in oven, are used to prepare in pressure cooker [25].
Aqueous solutions and softened fenugreek oils exert protective effects on mucous membranes in ulcer disease [26] and prevent colon cancer [27]. It is being utilized in the folk medicines for the treatment of cellulitis, tuberculosis and boils [28].
In Turkey, it has been found to be beneficial in healing internal wounds when taken with butter and sugar. It is used in healing hemorrhoids and it can be also used as a supplementary food supplement in the treatment of hyperthyroidism.
Pharmacological activities have been studied by Mehrafarin et al. [29] to explain the medicinal properties of fenugreek and its main metabolites. Many studies were conducted to increase the secondary metabolites of fenugreek by different applications (Table 1).
Part of fenugreek | Application | Secondary metabolites | References |
---|---|---|---|
Leaves | UV Radiation | Total phenols, Flavonoids, Alkaloids, Tannins, saponins, Anthocyanin content | El-Shora et al. [30] |
Hypocotyls of the sprouts for callus initiation | Mannitol and Sodium Chloride | Total phenolics, Total flavonoids, Tannins, | Hussein and Aqlan, [31] |
Seedling | Methyl Jasmonate | Diosgenin | Chaudhary et al. [32] |
Fenugreek plant | Trichoderma strains | Trigonellin | Hosseini et al. [33] |
Seeds and Callus | Cultured on MS medium | Trigonellin, Diosgenin | Altabtabaai et al. [34] |
Leaf and stem | Collected from the local market Surat, Gujarat | Phenol content, Flavonoids content, | Varsha and Jain, [35] |
Seeds | Collected from 50 regions of Iran | 4-hydroxy isoleucine, Trigonellin | Rajabihashjin et al. [36] |
Leaf | Water deficit, exogenous ethylene application and root symbioses | Trigonellin | Irankhah et al. [37] |
Growth stages (Vegetative, full flowering and well-developed pods) | Rainfeed conditions | Proximate composition, total phenols, tannins, flavonoids and saponins | Abdouli et al. [38] |
Fenugreek plants | Mycorrhizal fungal inoculum and exogenous methyl jasmonate; Water deficit | ABA, IAA, trigonelline, diosgenin | Irankhah et al. [39] |
Seeds | Charcoal and drought stress | Trigonellin, diosgenin | Bitarafan et al. [40] |
Plant tissues | Copper stress | Total phenols, Total flavanoids | Elleuch et al. [41] |
Seeds | Gamma irradiation | Trigonelline, nicotinic acid, Diosgenin, Mucilage content | Parchin et al. [42] |
Variation of fenugreek secondary metabolites in different cultural applications.
Fenugreek seeds contain the neuroprotective alkaloid trigonelline, which is one among the foremost alkaloids found in fenugreek seeds. Trigonelline consists of a methyl betaine derivative of nicotinic acid, aids in curing diabetes and treatment of neurodegenerative diseases. In addition, alkaloids like trimethylamine, neurin, choline, gentianine, carpine and betain are found in fenugreek. These alkaloids exhibit antibacterial, antiviral and memory improving activities [43].
Fenugreek also represents an important source of diosgenin, a saponin used as a precursor for the synthesis of steroid hormones. Diosgenin is a very valuable phytochemical due to its biological activities and pharmaceutical applications. In fact, this phytochemical has anticancer, anti-aging, cardioprotective and contraceptive properties [44, 45, 46, 47, 48, 49] and antiviral, antimicrobial, antifungal and insecticidal activities [50, 51]. Anticancer effect of diosgenin has also been investigated in a number of preclinical studies, including growth inhibition and apoptosis induction in human colon cancer cells [27] and cell cycle in different cancer cell lines [52] has been documented.
So, fenugreek seeds have anti-inflammatory, hypoglycemic effects, anti-diabetes, cardioprotective, anticancer, antimicrobial properties, antipyretic and analgesic properties [53, 54]. Therefore, breeding strategies should be re-validated to increase the amounts of important active substances such as diosgenin and trigonellin in fenugreek seeds. Genetic variation in fenugreek should be introduced and a combination of traditional and molecular approaches should be used. In addition, the advantage of applying mutants to tissue cultures should be used in fenugreek.
The fenugreek seeds contain polyphenolic compounds, which have been correlated to the beneficial health effects of fenugreek [55]. These polyphenolic compounds are known for several beneficial actions, such as antioxidant effect [56], cancer preventive activity [27], anti-diabetic effects [57] and hypocholesterolemic effect [12, 56].
In earlier studies Bors et al. [58] reported that the scavenging activities of phenolic substances are attributed to the active hydrogen donating ability of hydroxyl substituents. As an overall assessment, the presence of various phytochemicals, particularly naringenin and quercetin, may be responsible for the OH radical scavenging activity. Similarly, trigonellin isolated from ethanol extract of fenugreek seeds has been reported to reduce blood sugar and lipid profile in alloxane-diabetic rabbits [59]. This effect can be partially explained by the antioxidant properties of trigonellin due to its structural similarity to nicotinamide, which has an antioxidant effect [60].
Bukhari et al. [61] reported that fenugreek seed extract with methanol, ethanol, dichloromethane, acetone, hexane and ethyl acetate has a radical scavenging activity. In addition, Bhatia et al. [62] reported protective effect of fenugreek, on lipid peroxidation and on enzymatic antioxidants. Naidu et al. [63] reported that extracts of husk, fenugreek seed, and endosperm exhibited 72%, 64%, and 56% antioxidant activity respectively by free-radical scavenging method. Also, it was indicated that separation of fenugreek seeds into husk and endosperm could have advantage of process viability with respect to prior selective fractionation of bioactive components for their effective isolation.
In a similarly study, it was determined that fenugreek has a high phenolic content. Furthermore, antioxidant property was checked by reducing power, nitro blue tetrazolium (NBT) assay and H2O2 scavenging reported to show high superoxide and free radical scavenging [64].
Furthermore, Kaviarasan et al. [65] reported that 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals are more reactive than 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and unlike the reactions with DPPH radical which involve H atom transfer, the reactions with ABTS radicals involve electron transfer process. In addition, Shang et al. [66] identified five different flavonoids in fenugreek seeds, namely vitexin, tricin, naringenin, quercetin, tricin-7-O-beta-D-glucopyranoside, and fenugreek seed extract was found to have significant antiradical and antioxidant properties depending on the concentration.
In line with above researchers [65], they reported that an aqueous methanolic extract of fenugreek seeds was investigated for antiradical and antioxidant activity in different model systems, and antiradical activity was associated with the polyphenolic contained in the extract. As a result, it was determined that fenugreek seeds provide some important factors responsible for the antioxidant potential and provide evidence for numerous in vivo beneficial effects of seeds reported in the literature.
Similarly, Belguith-Hadriche et al. [67] investigated the hypocholesterolemic and antioxidant activities of various extracts of fenugreek seeds (water, methanol, ethyl acetate, hexane, dichloromethane) in rats fed cholesterol, and ethyl acetate only for rats fed a cholesterol-rich diet (HCD). It has been found that fenugreek extracts reduce triglycerides and low density lipoprotein cholesterol (LDL-C) and increase high density lipoprotein cholesterol (HDL-C). Based on these results, it was reported that ethyl acetate extract of fenugreek seeds had a significant hypocholesterolemic effect and antioxidant activity in cholesterol fed rats.
Furthermore, Liu et al. [68] determined the lipid peroxidation (LPO) and cyclooxygenase enzyme (COX) inhibitory activities of hexane, ethyl acetate, methanolic and water extracts to investigate the functional food use quality of fenugreek. They found that the extracts inhibited LPO by 55–95%, COX-1 by 6–87% and COX-2 by 36–70% at 250 lg/ml, respectively. Also, the isolates, excluding the saccharides, inhibited LPO and COX-1 and COX-2 enzymes between the ranges of 8–89%, 4–51% and 15–70%, respectively, at 25 lg/ml. The fenugreek seeds that were studied afforded 3.9 g of triglycerides and fatty acids, 6 g of polysaccharides and 233 mg of flavone C-glycosides per 100 g of seeds. The strong antioxidant activity in the LPO assays of the aqueous extract of fenugreek seed might be attributed to the flavones C-glycosides [69].
Likewise, the different solvent extracts of fenugreek seeds were used to examine the effects of extraction solvent on total phenolic content (TPC), DPPH and iron reducing antioxidant power (FRAP). It was observed that the extracts obtained using higher polar solvents were more effective than less ones, and the addition of 50% water to methanol, acetone or ethanol can enhance the extracting power and antioxidant activity estimation especially acetone and methanol. As a result, it was determined that the total phenolic content showed a good correlation with antioxidant activity FRAP and DPPH [70].
In similarly, Deshmukh et al. [71] reported that silver and iron oxide nanoparticles were successfully synthesized in a simple way at room temperature using an aqueous extract of fenugreek seeds. Then, all nanoparticles were characterized by various techniques to elucidate the stability and functionality of the nanoparticle. It has been determined that the nanoparticles synthesized with the assistance of ultrasound show higher stability and antibacterial and antioxidant activity due to the combined effect of ultrasound and biomolecules adhering to the surface of the nanoparticles.
Naidu et al. [6] also observed that the husk of fenugreek seeds contained higher total polyphenols (103.8 mg gallic acid equivalent/g and the total dietary fiber (77.1 g/100 g), insoluble dietary fibers (31.9 g/100 g) and soluble dietary fibers (45.2 g/100 g). The bark, fenugreek seeds and endosperm extracts were reported to exhibit 72%, 64%, and 56% antioxidant activity, respectively, by the free radical scavenging method. As a result, separation of fenugreek seeds into husk and endosperms showed that the process viability advantage.
The antioxidant properties of germinated fenugreek seeds were examined in a study conducted by Dixit et al. [72]. Different fractions of germinated seeds were used at different levels to determine their antioxidant potential. Tests used are ferric reducing antioxidant power, DPPH, feriylmyoglobin / 2,2-azobis-3-ethylbenzthiazoline-6-sulfonic acid, pulse radiolysis, oxygen radical absorbance capacity and lipid peroxidation in rat liver mitochondrial preparations. An aqueous fenugreek fraction showed the highest antioxidant activity. Since the amount of phenolic and flavonoid compounds can be correlated with antioxidant activity, the contents of these extracts were measured and their polyphenols, flavonoids and other components were determined by HPLC analysis. This study reveals significant antioxidant activity in germinated fenugreek seeds, which may be due in part to the presence of flavonoids and polyphenols.
As seen from previous studies, the obtained different results may be attributed to different extraction methods and solvents used, different cultivars, growing conditions, maturity stage at harvest, or the storage conditions and time elapsed before the seeds were analyzed. Synthetic drugs used for the treatment of the diseases like cancer, diabetic and the antioxidants used for some treatment have side effects such as mutagenic and carcinogenic effects [73]. Some patients also have resistance to the synthetic drugs. To overcome this problem there is need to find effective natural drugs from traditional medicine. Therefore, fenugreek, which possesses phenolic compounds and antioxidant activity should have the ability to counteract these situations and might be a good candidate for a herbal drug.
The antibacterial activity of the plant extraction has been extensively investigated in many studies. Microbiological analyses revealed that fenugreek extracts exhibit antimicrobial activity against numerous bacteria [74]. Haouala et al. [75] determined the aqueous extracts obtained from various plant parts of fenugreek, different solvents such as methanol, petroleum ether and ethyl acetate fractions and their effects against fungal strains such as
Many studies have indicated the effectiveness of fenugreek extracts against
Since cysteine-rich peptides, defensins have strong antifungal activity, the methanol-soluble fraction of fenugreek extract has been studied against nematodes and has been found to show nematicidal activity. It has also been reported to significantly cause the death of
In addition, Shaheed et al. [82] recorded that the inhibition results for each
In another study, the antibacterial effects of fenugreek oil against
Similarly, it was determined that fenugreek essential oil showed the highest activity against
Cancer remains one of the leading causes of death worldwide. Flavonoids could also significantly contribute to fenugreek’s anticarcinogenic properties. Fenugreek constitutes valuable raw material for the pharmaceutical industry that has long searched for effective cures for cancer.
Previous studies reported that fenugreek seeds have a preventive effect on cancer as in experimental models of cancer using cell lines or experimental animals.
Earlier studies revealed that seed extract of fenugreek importantly inhibits 7,12-dimethyl benz(a)anthracene-induced mammary hyperplasia and decreases its ratio in rats. It was also advised that anti-breast cancer preventive effect of fenugreek could be depending on the increasing apoptosis [87]. Furthermore, alcoholic whole plant extracts of fenugreek effected in vitro cytotoxicity against different human cancer cell lines such as IMR-32, a neuroblastoma cell line, and HT29, a cancer cell line [88].
A selective cytotoxic effect of fenugreek extract in vitro to a panel of cancer cell lines has been observed, including T-cell lymphoma by Alsemari et al. [89]. In addition, Sebastian and Thampan [90] and Prabhu and Krishnamoorthy [91] examined the growth of MCF-7 cells, which is an estrogen receptor positive breast cancer cell line, with ethanol extracts of fenugreek, and reported that the ethanol extract of fenugreek decreased cell viability and induced early apoptotic changes such as inversion of phosphatidyl serine and decreased mitochondrial membrane potential.
In a study conducted by Shabbeer et al. [92] treatment with fenugreek extract showed growth inhibitory effects on breast, pancreatic and prostate cancer cell lines but primary prostate or immortalized prostate cells remained unaffected. In addition, in a dietary study involving fenugreek seed powder, it reduced colon tumor incidence and hepatic lipid peroxidation in rats treated with 1,2-dimethylhydrazine and also increased catalase, superoxide dismutase, glutathione S-transferase and glutathione peroxidase activities in the liver [93].
Li et al. [94] recorded that diosgenin modulates the STAT3 signaling pathway in hepatocellular carcinoma by suppressing the activation of c-Src, JAK1 and JAK2. They also noted that diosgenin reduced the expression of various STAT3-regulated genes, inhibited proliferation, and potentiated the apoptotic effects of paclitaxel and doxorubicin, which could be a new and potential treatment option for hepatocellular carcinoma and other cancers. Also many researchers reported that diosgenin exhibited anticancer and antiaging activities, as well as cardioprotective and contraceptive properties [44, 45, 46, 47, 48, 49].
In addition, in different studies with diosgenin, it has antiproliferative activity such as prostate cancer (PC-3 and DU-145 cells) [95], colon cancer (HCT-116 and HT-29 cells) [96], erythroleukemia (HEL cells) [97], carcinoma (A431, Hep2 and RPMI 2650 cells) [98], stomach cancer (BGC-823 cells) [99], lung cancer (A549 [100], breast cancer (MCF-7) [101], hepatocellulacarcinoma (HepG2 and HCC cells) [102] and human chronic myeloid leukemia (CML) (K562 cells) [103].
As a result of the studies mentioned above, the role of fenugreek seeds and its main active ingredients as new supplements in diet-based preventive / therapeutic strategies to potentially alleviate human diseases remains an important area of study for future research [104].
Immunological changes include altered levels of cytokines and chemokines, changes in the numbers and activation states of various leukocyte populations, apoptosis, and fibrosis during diabetes. Therefore, treatment of diabetes and its complications may include pharmacological strategies to reduce inflammation [105]. Laroubi et al. [81] studied the prophylaxis effect of fenugreek seeds on renal stone formation in rats. And they said that the fenugreek can be used in the treatment of patients with calcic urolithiasis. Chauhan et al. [106] reported an antiinflammatory potential of fenugreek. Jung et al. [107] observed a reduction in the production of several inflammatory mediators, including NO and interleukins 1 and 6, in murine macrophages which had been pretreated with diosgenin and stimulated with lipopolysaccharide/interferon-𝛾.
In addition, Roberts [108] said that the gum, composed of galactose and mannose, is associated with reduced glycemic effect. Also, the hypoglycemic effect of fenugreek has been especially documented in humans and animals with type 1 and type 2 diabetes mellitus.
Xue et al. [109] reported that the fenugreek extract can lower kidney/body weight ratio and blood glucose and also improves hemorheological properties in experimental diabetic rats following repeated treatment for 6 weeks. A study on animals evaluated the hypoglycemic effects of the fenugreek seeds on dogs. The seeds lowered blood glucose levels, plasma glucagons and somatostatin levels; carbohydrate-induced hyperglycemia also was found to be reduced [110]. Most of the studies with polar fractions of fenugreek seeds point toward a strong anti-inflammatory and anti-arthritic activities mediated through anti-oxidant mechanisms [68, 111, 112].
In addition, Sharma et al. [113] recorded that guar gum of fenugreek prevents the rapid uptake of glucose in the small intestine, aids in blood sugar retention in diabetic patients and may also be effective in the treatment of hypercholesterolemia.
Especially recently, many of the beneficial properties of fenugreek have been experimentally proven and the potential of fenugreek’s therapeutic applications has been demonstrated. It has high economic values because of including a lot of bioactive compounds. The important compounds can be listed steroidal sapogenins such as diosgenin, alkaloids as trigonelline, flavonoids, tannins, amino acids, steroidal glycosides, protein and others.
As can be seen from this review, the phenolic acids, dietary fiber, saponins and proteins contained in fenugreek are valuable additives to improve human nutrition. Additionally, in neurological studies conducted with fenugreek, the antidiabetic, antifertility, anticancer, antimicrobial, antiparasitic, lactation stimulating and hypocholesterolemic effects of fenugreek have been proven by many researchers. So, it has been also universally used as a spice in a conventional food or it has been interfered to prepare for some functional foods.
In the future, studies on fenugreek are needed some important applications to increasing the popularity of fenugreek. In this context, researchers should be focused quality criteria as primer or secondary metabolite, different cultural and molecular application, different techniques from sown to harvest times of fenugreek. Further research will be required to determine to know the molecules responsible the antioxidant properties in these extracts. Also, fenugreek germplasm can be collected and subjected to intensive selection via modern breeding programs. In addition to these, by selecting genotypes with superior characteristics, gene transfer can be made by determining suitable genes among these genotypes and new fenugreek genotypes with desired properties can be obtained. In addition, studies on fenugreek leaves are limited and generally focused on fenugreek seeds. In this context, researchers should be focused the quality criteria as primer or secondary metabolite in fenugreek leaves.
This study will help the researchers to obtained optimal fenugreek production, optimum biochemical components and adapt to difference environmental, other and specific farming conditions. In the future, when fenugreek is evaluated with all these aspects, its economic, industrial and medicinal value may increase and add value to the relevant sector.
The authors declare no conflict of interest.
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Iron oxide nanoparticles and their nanocomposites have performed excellent in supercapacitor. Iron oxide as negative electrode has extended the working voltage window of a supercapacitor. The main problems associated with iron oxide based electrodes are their poor electrical conductivity and cycle stability. Therefore, a conductive carbon matrix has been added to the iron oxide based electrodes to improve the electrochemical performance. In this chapter, recent progress on iron oxide and its composite with different materials as electrode in supercapacitor is summarized. The various synergistic effects of nanocomposites and compositional engineering to enhance the electrochemical performance of iron oxide are also discussed.",book:{id:"10824",title:"Iron Oxide Nanoparticles",coverURL:"https://cdn.intechopen.com/books/images_new/10824.jpg"},signatures:"Rajan Lakra, Rahul Kumar, Parasanta Kumar Sahoo, Sandeep Kumar and Ankur Soam"},{id:"82030",title:"Magnetite Nanoparticles (Fe3O4) for Radio-Frequency and Microwave Applications",slug:"magnetite-nanoparticles-fe3o4-for-radio-frequency-and-microwave-applications",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.104930",abstract:"The size and shape dependent tunable electromagnetic (EM) properties of magnetite – Fe3O4 nanoparticles makes them an attractive material for various future electronics and biomedical device applications such as tunable attenuators, miniaturized isolators and circulators, RF antennas, EM shielding, and biomedical implants etc. The strategic design of RF devices requires specific dielectric and magnetic properties according to the applications, which in turn depends on the size and shape of the particles. At nanoscale, iron oxide’s magnetic and dielectric properties are very different from its bulk properties and can be tuned and enhanced by utilizing different synthesis approaches. In this chapter, we summarize electromagnetic properties of magnetite (Fe3O4) nanomaterials such as, complex permeability, complex permittivity, magnetic and dielectric loss tangents, saturation magnetization, temperature dependence, and ferromagnetic resonance; and how these properties can be optimized by varying different synthesis parameters. Finally, Fe3O4 nanocomposites will be explored by using different synthesis approaches for implementation of RF and microwave applications and we will conclude the chapter with future recommendations.",book:{id:"10824",title:"Iron Oxide Nanoparticles",coverURL:"https://cdn.intechopen.com/books/images_new/10824.jpg"},signatures:"Poonam Lathiya and Jing Wang"},{id:"81878",title:"Recent Progress and Overview of Nanocomposites",slug:"recent-progress-and-overview-of-nanocomposites",totalDownloads:18,totalDimensionsCites:0,doi:"10.5772/intechopen.102469",abstract:"Nanocomposites are versatile materials because of possessing superior properties as compared to their parent materials. Due to their improved electrical, mechanical, thermomechanical, electronic, optoelectronic, thermal, and magnetic properties, these materials are receiving much attention from researchers all over the world. In every field, the focus of the research is to develop such materials which have low weight, superior strength, and enhanced performance as well as cost competitiveness in comparison to existing materials. The nanocomposite materials have been used in the fields of avionics, biomedical, auto industry, sports industry, oil/gas, construction, food industry, agriculture industry, and information technology. This chapter addresses the synthesis, unique properties, and diverse applications of nanocomposites in different fields.",book:{id:"10825",title:"Nanocomposite Materials",coverURL:"https://cdn.intechopen.com/books/images_new/10825.jpg"},signatures:"Muhammad Hafeez"},{id:"81328",title:"Nanocomposites Thin Films: Manufacturing and Applications",slug:"nanocomposites-thin-films-manufacturing-and-applications",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.103961",abstract:"Thin films of nanocomposite materials arouse a lot of interest due to their excellent mechanical, electrical, optical, tribological properties and also by the vast field of application. This chapter covers some techniques of thin films growth, such as the processes of physical vapor deposition, such as magnetron sputtering; the processes of chemical vapor deposition; layer-by-layer; among other techniques. Additionally, relevant features and applications of some nanocomposites thin films are presented. The wide variety of thin films growth techniques have allowed the development of several devices including those that act as: transistors, actuators, sensors, solar cells, devices with shape memory effect, organic light-emitting diodes (OLEDs), thermoelectric devices.",book:{id:"10825",title:"Nanocomposite Materials",coverURL:"https://cdn.intechopen.com/books/images_new/10825.jpg"},signatures:"Weslley Rick Viana Sampaio, Petteson Linniker Carvalho Serra, Noelio Oliveira Dantas, Rômulo Ríbeiro Magalhães de Sousa and Anielle Christine Almeida Silva"},{id:"81463",title:"Perovskite-Based Nanomaterials and Nanocomposites for Photocatalytic Decontamination of Water",slug:"perovskite-based-nanomaterials-and-nanocomposites-for-photocatalytic-decontamination-of-water",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.102824",abstract:"The exploration of functional nanomaterials with superior catalytic activity for practical photocatalytic water decontamination is of significant importance. 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By the end of the chapter, the remaining challenges and perspectives for developing efficient perovskite-based photocatalysts with potential large-scale application are highlighted.",book:{id:"10825",title:"Nanocomposite Materials",coverURL:"https://cdn.intechopen.com/books/images_new/10825.jpg"},signatures:"Yousef Faraj and Ruzhen Xie"},{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:40,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"38",type:"subseries",title:"Pollution",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment",scope:"\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). 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