Havovi Chichger

Anglia Ruskin University

CITIZENSHIP British EDUCATION Undergraduate King’s College London, UK, Biochemistry, B.Sc, 2004. Graduate School University College London, UK, Physiology, Ph.D., 2011. Continued Education Sheridan Centre, Brown University, USA, Reflective Teaching, 2014. Anglia Ruskin University, UK, Learning and Teaching, PgCert, 2016. CURRENT POSITION Senior Lecturer in Biomedical Science, Course Leader for MSc Applied Bioscience, Department of Biomedical and Forensic Sciences, Faculty of Science and Technology, Anglia Ruskin University, Cambridge, UK. 2015-present. POSTGRADUATE TRAINING Postdoctoral Fellowship, Vascular Research Laboratory, Alpert Medical School, Brown University USA. 2011-2015. UNIVERSITY COMMITTEES AND SERVICE 1. Member, Faculty Research Doctoral School Committee at Anglia Ruskin University, 2017 - present 2. Member, Biological safety and GMO Committee at Anglia Ruskin University, 2015 – present 3. Member of the Postdoctoral Advisory Panel, Brown University, 2012-2015. 4. Organizer and Chair, Providence VA Medical Center, Research Journal Club, 2013 – 2015. 5. Organizer, Alpert Medical School of Brown University, Pulmonary Research Journal Club, 2014 – 2015. 6. Member of Advisory Board for Biology and Biotechnology Program at Bristol Community College, 2013-2014. 7. Member of STEM Postdoctoral Career Panel, Brown University, 2013. 8. Member, IACUC Committee, Providence VA Medical Center, 2013 – 2015. OTHER COMMITTEES AND SERVICE 1. Member of Cambridge University Cardiovascular Research Initiative, 2015 – present. 2. Ad hoc reviewer for Biotechnology and Biological Sciences Research Council, 2015 – present. 3. Facilitator for Vascular Biology session at American Thoracic Society conference, 2014 4. Member of Editorial Board for The Journal of Pulmonology, 2014-present. 5. Member of Editorial Board for Postdoc Journal, 2012-present. 6. Member of Women in Physiology committee, American Physiological Society, 2012-present. 7. Facilitator for Poster Session, American Thoracic Society, Philadelphia, 2013. 8. Mentor for APS Minority Travel Fellows at Experimental Biology conference, 2012-2013. MEMBERSHIP IN SOCIETIES 2017-present Professional Member, Diabetes UK 2016-present Fellow of Higher Education Academy 2015-present Member, European Federation for the Study of Diabetes. 2012-2017 Early Career Member, American Heart Association. 2012-present Member, American Physiological Society. 2012-2017 Member, American Thoracic Society. 2009-2011 Member, American Society of Nephrology. 2007-present Member, The Physiological Society UK. ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS 1. Lizunkova P, Enuwosa E, Chichger H. Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium. Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):71-81. 2. Harrington EO, Vang A, Braza J, Shil A, Chichger H. Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2018 Jan 1;314(1):L165-L176. 3. Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2017; 312(5), L748-L759. 4. Chichger H, Cleasby M, Srai KS, Debnam ES, Unwin R.J, Marks J. Differential regulation of renal glucose transporters: Implications for diabetic nephropathy. Experimental Physiology. (2016) 101 (6):731-42 5. Chichger H, Braza J, Duong H, Boni G, Harrington EO. Select Rab GTPases regulate the pulmonary endothelium via endosomal trafficking of VE-cadherin. American Journal of Respiratory Cell and Molecular Biology. (2016) 54 (6):739-81 6. Chichger H, Braza J, Duong H, Stark M, Harrington EO. Vasculogenesis in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2015) 309 (7):L700 7. Chichger H, Vang A, O’Connell K, Zhang P, Harrington EO, Mende U, Choudhary G. PKC δ and βII Regulate Angiotensin II Mediated Fibrosis through p38: A Mechanism of RV Fibrosis in Pulmonary Hypertension. American Journal of Physiology – Lung Cellular and Molecular Physiology. (2015) 308 (8):L827-36. 8. Chichger H, Braza J, Duong H, Harrington EO. p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. FASEB J. (2015) 29 (3):868-81. 9. Chichger H, Braza J, Duong H, Harrington EO. SHP2 and FAK protein interactions regulate pulmonary endothelium barrier function. American Journal of Respiratory Cell and Molecular Biology. (2015) 52 (6):695-707. 10. Jacquillet G, Chichger H, Unwin RJ, Shirley DG. Luminal proteolytic activation of the collecting duct epithelial sodium channel (ENaC) and its possible role in renal sodium reabsorption in vivo. Nephrology Dialysis Transplantation. (2013) 28 (4):839-45. 11. Chichger H, Grinnell KL, Casserly B, Chung CS, Braza J, Lomas-Neira J, Ayala A, Rounds S, Klinger JR, Harrington EO. Genetic Disruption of PKCδ Reduces Endotoxin-Induced Lung Injury. American Journal of Physiology-Lung Cellular and Molecular Physiology. (2012) 303 (10):L880-8. 12. Grinnell KL, Chichger H, Braza J, Duong H, Harrington EO. Protection against LPS-induced pulmonary edema through the attenuation of PTP1B oxidation. American Journal of Respiratory Cell and Molecular Biology. (2012) 46:623-632. 13. Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, Unwin RJ, Lutz TA, Spector AC, Le Roux CW. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiology & Behaviour. (2011) 104:709-721. 14. Ceskova P, Chichger H, Wallace M, Vojtesek B, Hupp TR. On the mechanism of sequence-specific DNA-dependent acetylation of p53: The acetylation motif is exposed upon DNA binding. Journal of Molecular Biology. (2006) 357:442-456. BOOK CHAPTERS Chichger H, Grinnell KL, Harrington EO. Investigation of Protein kinase C Isoforms in the Formation of Focal Adhesion Complexes by ECIS. In: Cancer, Metastasis, Biology and Treatment: Electric Cell-Substrate Impedance Sensing in Cancer and Cancer Metastasis Research, edited by Jiang, W.G. Dordrecht, The Netherlands: Springer, 2012, volume 17, P 21-39. PUBLISHED ABSTRACTS From 2009 to present, I have over 40 published abstracts in journals ranging from Proceedings of the Physiological Society, Journal of American Society of Nephrology, Genes & Nutrition, FASEB Journal and American Journal of Respiratory and Critical Care Medicine. INVITED RESEARCH PRESENTATIONS From 2009 to present, I have been invited to present my research at over 28 institutions and conferences including Rhode Island Hospital, Harvard School of Public Health, National Institute of Medical Research, Experimental Biology, Kings College London, Imperial College London and University of Cambridge. RESEARCH GRANTS 1. “Activation of bitter taste receptors, through bitter agonists, protects the retinal endothelium against vascular leak” Role: Mentor, Principal Investigator Vacation Studentship Grant#: 206978/Z/17/Z 01/06/2017-31/07/2017 Agency: Wellcome Trust Amount: £2000 (stipend) 2. “Artificial sweeteners reduce vascular permeability leading to diabetic retinopathy, through sweet taste receptor signalling pathways” Role: Mentor, Principal Investigator Vacation Studentship Grant#: 202624/Z/16/Z 01/06/2016-31/07/2016 Agency: Wellcome Trust Amount: £2000 (stipend) 3. “Artificial sweeteners reduce diabetes-induced vascular permeability through sweet taste receptor signalling pathways” Role: Principal Investigator Effort: 20% Grant#: 1450 16/10/2015-30/09/2016 Agency: Diabetes UK Amount: £15,000 4. “Mechanisms regulating the pulmonary endothelium through VE-cadherin trafficking” Role: Principal Investigator Effort: 100% Grant #: 13POST16860031 01/07/2013-01/04/2015 Agency: American Heart Association Amount: £99,897