\r\n\tOne basic topic is that of expression manipulation: combining, expanding etc, and the applications of this scholar topic needs focusing on.
\r\n
\r\n\tThe general topic of "polynomials" is very large, and here the focus is both on scholar/student basics of it, and on applications of some special polynomials in science and research.
\r\n
\r\n\tAn important topic of the book is "algebraic curve". Here the approaches are multiple: basic/scholar on one hand, and applications on the other hand. It must be noticed the use of algebraic curves properties in the field of differential equations, for example for finding the singularities.
\r\n
\r\n\tGrobner basis is a very modern and applied topic of algebra. Here we must outline the great importance of Grobner basis and polynomial ideals manipulation, in the differential equations field, an example being in fast finding normal forms of differential systems.
\r\n
\r\n\tRelated to this last topic of the book, but applying to all specified topics, it must be noticed the importance of numeric algorithms. The importance of software algorithms in all fields of science is continuously increasing. Therefore, computational approach of the specified algebraic topics is very useful, with applications in other mathematical and scientific fields.
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\n
1. Introduction
\n
\n
1.1 Is CRS directly caused by infectious agents?
\n
Our current state of knowledge indicates that chronic rhinosinusitis (CRS) is not directly caused by infectious agents [1]. Instead, the current paradigm states that CRS is a spectrum of “self-perpetuating” non-infectious inflammatory processes. If this is the case, that would mean that repetitive, long term, systemic antibiotic therapy has little to no role in the treatment of CRS, except in the event of an acute exacerbation. Furthermore, this would suggest that clinical improvement of CRS would be more appropriately explained by the reduction of inflammatory injury as a whole, and only secondarily by the amelioration of bacterial load and the resultant removal of super-antigens.
\n
Albeit this working theory pivots upon a non-infectious etiology it does raise many concerns in the direction of microbiology. The most paramount of which is that the misappropriate, frequent, and long term use of antibiotics actually selects for a pathological microflora, composed of microorganisms resistant to antibiotics, which may also form biofilms that may never be eradicated [1]. These biofilms may then act as the perfect stage for future acute exacerbations, functioning as a protective bunker for bacteria lying dormant within the film, and even create quasi-resistant bacteria. For example, a naturally antibiotic-sensitive bacterium contained within a biofilm may be out of reach of the action of an antibiotic, rendering it resistant-in-vivo.
\n
This idea is closely paralleled and supported by animal models of Pseudomonas-biofilm formation within sinus mucosa; where, Pseudomonas-biofilm required 400 times the concentration of tobramycin to be eradicated. Similarly, topical antibiotics are frequently ineffective at standard doses, which is often considered clinical proof of the non-bacterial etiology of CRS [2]. However, whether or not the proposed explanations are clinically valid for a non-bacterial mechanism of CRS remains a debatable issue and should be carefully evaluated in the context of published studies.
\n
Now, we will review these questions in a step-by-step fashion: physiology, sinus microflora, and recent discoveries on the role of punch biopsy in CRS and its detection of deep-tissue sinus infection.
\n
\n
\n
\n
2. Is a healthy sinus cavity free of bacteria?
\n
So, now the question is, is sterility synonymous with well-being? By using microbiome technology to detect difficult to culture bacteria, it was observed that bacteria are present in both healthy and diseased sinuses [3]. However, a pilot study on CRS patients actually discovered a significantly lower taxa of bacteria than their healthy control. So, at first glance it may look like the opposite, a lower number of bacteria is correlated with a higher likelihood of CRS. Does this point to a non-infectious etiology, then?
\n
Importantly, these microbiome studies did not only reveal a difference in absolute number of bacteria, but in the content of the bacterial flora. Further analysis revealed that the bacterial taxa of the CRS patients was largely defined by relatively high numbers of unique single species, such as Corynebacterium tuberculostearicum, while microbiome analysis in the healthy control group showed a relative abundance of Lactobacillus spp., Enterococcus spp., and Pediococcus spp., but what does all of this mean in practice? These findings suggest that the etiology of CRS may hinge upon balance and equilibrium, and not at all upon bacterial load.
\n
To investigate this hypothesis further, a study was designed on a mouse model of inflammatory sinusitis. This study revealed something extremely interesting. Sinus infection by C. tuberculostearicum led to hyperplasia [3], but not by itself. This hyperplasia only occurred with the administration of antibiotics. It looks that the use of antibiotics backfired. Upon antibiotic treatment the commensal bacteria of the healthy sinus cavity were eliminated, selecting for an antibiotic resistant strain C. tuberculostearicum, which became opportunistically pathogenic without a commensal microflora to police its growth. But what would happen if we rebalanced our flora? Could this process be reversed?
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Interestingly enough, upon the addition of the Lactobacillus sakei the process reversed entirely, returning the sinus cavity to its natural state. The conclusion of this intriguing study was that antibiotic treatment of acute rhinosinusitis may be a “Catch-22”, and although it may rid the body of the archetypal bacteria of acute sinusitis, it may contribute to the future development of persistent sinusitis and/or CRS. These findings spark many questions and begin to steer the medical mind toward similar situations within different specialties.
\n
Taking these discoveries of bacterial imbalance into consideration, it may be appropriate to draw analogies across specialties, and explore the realm of microbiotic imbalance in the upper respiratory tract as it relates to the female urogenital tract. We may be able to draw important conclusions in the pathogenesis of floral-imbalance-induced-CRS through the data analysis of microbiome studies in bacterial vaginosis (BV). BV is an infection in which anaerobic bacteria overgrow vaginal mucosa as a direct result of the, often inadvertent, elimination of Lactobacillus species [4]. These species naturally secret bactericidal H2O2 that kills anaerobic species—protecting the delicate membranes of the vaginal mucosa. Just as CRS, BV is frequently a recurrent process. However, a very simple single treatment with Metronidazole and/or recolonization with Lactobacillus often restores the health of mucosal membranes. It may be an oversimplification of a complex disease state, but the possibility of a similar etiology and therefore similar non-invasive cost-effective treatment is tantalizing.
\n
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2.1 Alternative thesis: CRS involves direct bacterial infection
\n
As much evidence as there may be for the noninfectious hypothesis of CRS, there is just as much supporting the opposite. So where does the truth lie? As with most things in life, most likely somewhere in the middle. Either way, here we will explore the possibility of infectious CRS, and some of the most recent discoveries and theories behind it.
\n
The noninfectious hypothesis of CRS is certainly a tantalizing one, but it is strongly challenged by the alternative hypothesis [5]. The authors of this chapter tend to lean toward the more active process of infection as the most common etiology, and we propose that the predominant progression of CRS directly involves bacterial infection. Furthermore, we believe that most of the theories and concepts pointing toward a noninfectious etiology, have been improperly evaluated and interpreted, and when reanalyzed tend to support an infectious cause of CRS.
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Many parallels can be drawn between the two main arguments, one of which is the selection of microflora and or pathogens by inadequate or improper antimicrobial treatment. Some pathogens, such as E. coli, are able to both actively and passively elude destruction and clearance through multiple mechanisms, and current studies are pointing toward the fact that we as clinicians are inadvertently selecting for them. Through mechanisms similar to those described in the previous sections, incomplete treatment of bacterial sinusitis looks to be inducing the escape of such organisms from the reach of the immune system as a whole, as well as antibiotics specifically, by driving these microorganisms into our body’s white cells or deep within the sinus mucosa. Simultaneously, the resultant disruption of the commensal bacterial community and mucosal integrity of the sinus leads to the formation of biofilm, which in our opinion is both a strong supplementary contributor and a direct cause of subacute and chronic infectious processes.
\n
As discussed previously, a weakened microflora may contribute to the dysfunction of the sinus mucosa and disruption of the general local immune state. This, in combination with a slew of other complex factors, creates the perfect platform for the formation of a biofilm. Once formed, biofilm contributes to the failure of the antibiotic treatment by preventing any significant antibiotic penetration. Bacteria hiding within the structure of the film, become effectively invulnerable, when in any other situation they would be easily eliminated. As an added layer to the issue, superficial swab and culture of the mucosal surface may be completely misleading. A positive bacterial culture of the biofilm showing in vitro antibiotic sensitivity may misdirect therapy entirely. Although you’ve confirmed in vitro effectiveness of therapy in regard to your surface culture, the chosen antimicrobial will most likely miss any pathogen lying deep within the film, interstitium, or intracellular space, rendering the chosen treatment clinically moot when used in-vivo.
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Now put yourself in the shoes of the clinician. You’ve swabbed properly and sent for culture and sensitivity, then treated accordingly, but there is no clinical improvement in your patient’s state of health. So, what do you do next? What conclusions may you draw? Such a cycle of negligible response to antibiotic therapy may inappropriately perpetuate the idea of pathogen independent CRS, when in reality it should raise questions of drug choice, administration, and adjunct therapy.
\n
This thought process brings one particular example to mind and into question. Recently Antunes et al. showed that a Pseudomonas containing biofilm required 400 times the concentration of tobramycin to be eradicated than its control counterpart. While this finding became a warning, heeded by many, against the “ineffective” antibiotic treatment of biofilm, and even further, considered by some as the disproval of a bacterial origin of CRS, this may be a grave misunderstanding. Looking back to our foundations in pharmacology we must remember that many antibiotics have near-no activity on intracellular pathogens hiding within white or epithelial cells [6]. A fantastic real-world example of this being the aminoglycosides, like tobramycin, in particular.
\n
In the world of microbiology the classic model for establishing intracellular infection in vitro is achieved by introducing an aminoglycoside to the infected epithelial cell culture. Once introduced the aminoglycoside does in fact eliminate the extracellular bacteria, however counterintuitively it actually positively selects for the intracellular pathogens. This pharmacological model is well established in many fields of microbiology and Infectious Disease research, often exploited in many classic experimental algorithms, across many specialties—except, it seems, for those in the area of ENT and CRS [6]. Such an oversight may have immensely detrimental effects on the validity of conclusions drawn from an otherwise extremely important finding.
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The current paradigm of thought, that chronic rhinosinusitis has no direct infectious etiology, is further challenged by the clinical efficacy of treatment with Mupirocin lavage in CRS patients who had positive endoscopically guided cultures for Staphylococcus aureus [7]. In one recent investigation of CRS, 15 of 16 patients treated with Mupirocin-saline nasal irrigation, twice daily for 3 weeks, saw significant clinical improvement followed by a negative repeat culture for S. aureus after treatment. A follow-up double-blinded, placebo-controlled, study on 22 patients with CRS non-responsive to surgery demonstrated infection clearance in 8 of 9 patients after 1 month of mupirocin treatment [8]. Although the clinical improvement could be explained by the resolution of an acute exacerbation or the elimination of Staphylococcus super-antigens, these studies clearly challenge the current dogma of noninfectious CRS, and furthermore may directly support a pathogenic etiology of chronic sinusitis.
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3. Finding E. coli in patients chronically ill with sinusitis
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There is much left to understand and discover about the pathogenesis of CRS, from both the infectious and non-infectious standpoints, and it will be many years before we have a full grasp on the matter, if ever. In the meantime, many groups are publishing some interesting studies with very exciting results, and conclusions.
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Recently, we have reported on the importance of proper biopsy in chronic sinusitis, and how such data may influence treatment and outcomes [5]. Interestingly, the predominance of specific pathogens differs in congruence with the method of sample collection. For instance, with swab and culture bacterial growth is most commonly dominated by the classic Gram-positives implicated in sinusitis. However, when samples are collected intraoperatively, by punch biopsy, the script is flipped and a predominance of Gram-negatives, including E. coli, is found [9, 10]. Therefore, logic dictates that if antibiotic therapy targets only the classic culprits of sinusitis, with Gram-negatives present, we may be achieving an incomplete or even inappropriate eradication of microflora and pathogens. This could explain and contribute to therapeutic failure in recurrent sinusitis, its transition into chronicity, and its interpretation as noninfectious [11, 12, 13, 14, 15, 16, 17, 18, 19].
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In general, the presence of nonclassical pathogens such as Gram-negatives, namely E. coli, has been poorly documented. However, more and more groups are finding E. coli in patients chronically ill with sinusitis, and the question remains, “Are these contaminants, or are they true pathogens?”. By definition if the latter is true, and these isolated E. coli are pathogenic, there should be evidence of their ability to produce disease, through the demonstration of various virulence factors [20, 21, 22]. Alternatively, if they are non-pathogenic and represent random contamination or commensal properties then there should be no evidence of genetic markers of virulence. So far, the nature of E. coli virulence and potential for cause of CRS remains largely unknown [23, 24, 25, 26]; and while numerous studies have explored the role of virulence genes in chronic and recurrent GI and Urinary Tract infections, no such data has been available in regard to chronic sinusitis, until recently [5, 23, 24, 25].
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We recently published the first report demonstrating an association between a highly pathogenic E. coli, chronic sinusitis, and the resolution of symptoms upon E. coli targeted therapy [5]. Our findings support the theory that a non-classical pathogen may lurk below the radar in non-pharmacologically-responsive CRS and would only be detected by the use of proper techniques. When we performed intraoperative biopsy and culture on our chronic sinusitis patients, followed by genetic analysis of virulence factors, we found the presence of a clearly non-random pathogenic E. coli. These E. coli carried genes encoding multiple virulence factors, granting them the ability to produce biofilm. Upon catering our antibiotic therapy to each patient’s biopsy and culture, we were able to obtain long term resolution of symptoms. These results, as a whole, lead us to believe that there very well may be genetic uniformity amongst E. coli isolated from patients suffering from CRS. These are not randomly occurring colonizers, or opportunistic colonizers.
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3.1 Genetic analysis discover highly pathogenic E. coli in CRS
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Generally, E. coli can be grouped genetically. Commonly, commensal E. coli are placed in phylogenetic groups A or B1, while pathogenic isolates are grouped in B2 or D [27, 28]. Upon in-depth genetic analysis of these patients, we found that 77% of isolated E. coli belonged to the pathogenic phylogenetic group B2, while only 23% belonged to the commensal B1 group [5]. This is concerning, not only due to shear pathogenicity, but the numerous dangerous traits associated with the bacteria in group B2. E. coli within this group are commonly capable of iron acquisition, granting them the ability to invade cells and multiply intracellularly and even within the blood stream. This makes members of the phylogenetic group B2 particularly toxic—contributing greatly to the inflammatory process and tissue injury of chronic infection.
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Diving deeper, we find that these E. coli share many attributes with extraintestinal-pathogenic-E. coli. However, other features suggest that they might be specifically pathogenic to sinus tissue [29, 30]. One example of this tissue specificity is the sfa adhesin gene, normally associated with meningitis [31]. It is no stretch of the imagination to think that two anatomical structures, in such close proximity as the sinuses and the meninges, may be invaded through similar cytophysiological pathways. Especially by multiple bacteria with a generally enigmatic local affinity, whom happen to share virulence factors. This association needs to be explored further, but for now it is exciting to think that we may be able to better explain local affinity (tropism) to the head and neck through such mechanisms.
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Other highlights of this genetic analysis include the finding of both the hlyA and usp genes. These genes encode for the formation of bacterial toxins and are only present in highly virulent bacterial strains. In this patient group, they were present in over 70% of the E. coli isolates. By the other side of the same token, isolates were found to lack dra/afa adhesins, which are implicated in chronic and recurrent UTI and gestational pyelonephritis. Such a bold distinction may further support the idea that these isolates represent a novel subset of E. coli, with a unique genome, and possibly even tropism for the mucosa of the paranasal sinuses [32].
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Unexpectedly, there were three genes that were found in 100% of isolated E. coli from our patients. These genes were agn43, fimG/H, and fyuA [33, 34, 35, 36]. All of which are associated with UTI, and play a role in biofilm formation: agn43 assists in E. coli-E. coli self-adhesion, fimG/H codes for type 1 fimbriae allowing for E. coli to aggregate and adhere to mannose receptors on mucosal membranes, while fyuA assists in iron scavenging and is often implicated in septicemia.
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Possibly most shocking of all is that, when analyzed via a pseudo-phylogenetic tree, these genes had closely associated genetic loci, which signifies a very probable cooperation amongst them. This raises a very concerning question. Could these three genes, working together, code for some sort of “super biofilm”? This could explain how and why so many mono-therapies and empiric treatments fail to yield any improvement in patients who suffer from CRS. A biofilm of this nature would in essence be both a defensive and offensive fortification for the pathogen. A sort of moated fortress with large watch towers, never allowing antibiotics or the host immune system to penetrate it, creating an ideal environment for lingering infection and chronic inflammation.
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The resolution of CRS—following FESS, intra-operative biopsy, and antibiotic therapy targeted toward the resultant culture and sensitivity—is highly suggestive of E. coli’s strong contribution to the disease state of this patient population. Undoubtedly, this all hinges upon the genetic makeup of these bacteria, and the fact that their genetic code is set for pathogenesis by carrying the information necessary to express virulence factors, including the production of biofilm [37, 38]. Further deductive reasoning leads us to believe that, E. coli is a generally undermined and undetected etiologic factor of CRS and a major contributor of inflammation in these patients. Whether or not the presence of biofilm producing E. coli is directly responsible for the poor therapeutic response, after FESS alone, will continue to be explored in more detail [39, 40, 41, 42].
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As with all, there are limitations to this study that should be recognized. For example, the present investigation was a study of healthcare-seeking adults; only including those that were E. coli positive, raising a very important question. To what extent do these results apply to the general population? Next, due to the resolution of symptoms and subsequently negative cultures, along with consideration for cost and patient comfort, we did not perform a follow-up punch biopsy and analysis.
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4. Future studies
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Future studies should investigate the role of important factors in human health, such as the effects of hormones, like estrogen and progesterone, on chronic sinusitis [43, 44]. Which are known to control the immune system. We must also further explore the effects of obesity and diabetes mellitus on the risk of infection, as well as the relation of anatomical structure and function on the role of bacterial colonization. All of these factors change the expression of mucosal receptors, which is often exploited by various bacterial species, easing colonization and/or infection [32, 45].
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In regard to the possibility of hormonal control of the immune system of the upper respiratory tract, we speculate that the head and neck may be analogous to the female urogenital tract. Wherein sensitivity to infection rises during the secretory and proliferative phases of the menstrual cycle [44]. Exploring further in this direction, the anatomical structure of the upper respiratory system appears to resemble the urogenital tract in many ways. Within the urinary tract an ascending infection begins with the colonization of vaginal introitus, before migrating proximally [21]. Genital colonization with E. coli may progress to infection of the urethra, which then ascends to the bladder, and further up to the kidneys via the ureters. This is made possible through the exploitation of tissue specific receptors to which bacteria anchor via specialized adherence structures called fimbriae [46, 47]. This process of bacterial migration results in acute pyelonephritis, often followed by chronic kidney infection with even further spread to the blood stream and resultant urosepticemia [48, 49, 50]. Similarly, we implore the medical community to consider the oropharynx, nasal cavities and paranasal sinuses as another anatomical system conducive to similar ascending infections [21, 45]. Beginning with the colonization of the oral and nasal cavities, bacteria may migrate “upstream” to the maxillary and then frontal sinuses, as well as others along the way via similar receptor-ligand interaction. All of which may be complicated by anatomical variation, anomaly, and pathology, ranging from nasal polyps and turbinate hypertrophy to choanal atresia and structural issues of the sort. These problems may be caused by everything from allergy to genetic mutation—resulting in a slew of aggravating factors, expression of specialized epithelial cell types, and tissue receptors—all contributing to the risk of chronic rhinosinusitis.
\n
\n
\n
5. Considerations and conclusions
\n
All things considered, chronic sinusitis remains a bit of an enigma. However, the more we explore the better we will be able to understand the complex multifactorial etiology that’s sure to be lying below the surface. That being said, we’ve learned and discovered so much as a medical community in recent years, we believe there is no better time than now to begin making the most of it.
\n
Keeping in mind the most recent publications and studies, we urge physicians to consider intraoperative punch biopsy on all of their chronic sinusitis patients [5]. Biopsied samples should be homogenized, and host cells should be exposed to membrane destabilizing buffers, lysing them and releasing trapped intracellular bacteria, allowing for the most thorough culture and analysis. Considering that a direct culture of the sample on solid media may not always be fruitful, we recommend the use of liquid media which may better allow the growth and detection of bacteria, even at low numbers. Next, cultures should be tested individually for antibiotic sensitivity and a personalized therapy should be prescribed to each individual patient. Finally, we also urge you to consider sending bacterial isolates for genotyping [35, 48, 51, 52, 53, 54, 55, 56, 57]. Through doing so we can finally stop asking of ourselves if we’re fighting the right bug and know for certain that if it expresses virulence it is part of the problem.
\n
We believe that through the use of these methods we may be able to better differentiate between specific etiologies of CRS within our patients, and through doing so we hope that we can avoid inappropriate antibiotic use, repeat surgeries, and prolonged treatment. Giving our patients their health and quality of life back faster and more effectively than ever.
\n
In conclusion, we hope that personalized medicine may one day overshadow empiric treatment in chronic sinusitis, and all of our patients will be catered to with the utmost efficiency. With further testing and experimentation, we may be able to someday use vaccines or bacterial adhesion blockers to augment our therapies [30, 58]. Using genotyping to pick and choose what’s best for our patients, we may be able to target specific virulence factors that allow such abilities as iron binding or cellular adherence, effectively rendering those bacterial invaders non-pathogenic. Through interdisciplinary exploration we may be able to adopt and adapt what other specialties have learned and use it to restore mucosal and micro-floral balance, and band together to fight bacteria and biofilm together as a medical community.
\n
\n
Acknowledgments
\n
We thank you Nowicki Institute for Women’s Health Research, Nashville, Tennessee, USA for support.
\n
\n
Conflict of interest
\n
Authors declare no conflict of interest.
\n
\n',keywords:"chronic sinusitis, rhinosinusitis, E. coli, biofilm, genotype, virulence factors, antibiotic treatment, antibiotic resistance, biopsy",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65465.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65465.xml",downloadPdfUrl:"/chapter/pdf-download/65465",previewPdfUrl:"/chapter/pdf-preview/65465",totalDownloads:341,totalViews:0,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,dateSubmitted:"October 22nd 2018",dateReviewed:"January 9th 2019",datePrePublished:"February 11th 2019",datePublished:"December 4th 2019",dateFinished:null,readingETA:"0",abstract:"Chronic sinusitis leads to unresolved infection and inflammation resulting in tissue remodeling, then further propagates the vicious cycle of deterioration and dysfunction of the sinuses’ natural defense mechanisms, and yet another cycle of infection and mucosal injury. Antibiotic therapy targeting pathogens classically implicated in sinusitis could augment the risk of therapeutic failure through the natural selection of resistant and/or virulent pathogens, especially in the presence of Gram-negative E. coli. Our recent demonstration of highly pathogenic E. coli, detected through intraoperative biopsy of sinus tissue, allowed the resolution of chronic sinusitis symptoms upon E. coli targeted therapy. The isolated E. coli carried three genes, each coding biofilm formation, which may, in part, account for the chronicity of E. coli sinusitis. We recommend that, patients with chronic sinusitis be considered for intraoperative biopsy for unusual pathogens, therefore allowing targeted therapy. In the future, use of vaccines and biofilm inhibitors might be an effective therapeutic consideration.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65465",risUrl:"/chapter/ris/65465",book:{slug:"rhinosinusitis"},signatures:"Alexander Nowicki, Natalie Nowicki, Stella Nowicki, Alfred Samet, Michal Michalik, Roger Su, James K. Fortson and Bogdan Nowicki",authors:[{id:"281641",title:"Prof.",name:"Bogdan",middleName:null,surname:"Nowicki",fullName:"Bogdan Nowicki",slug:"bogdan-nowicki",email:"bnowicki1949@gmail.com",position:null,institution:null},{id:"290331",title:"Dr.",name:"Alexander",middleName:null,surname:"Nowicki",fullName:"Alexander Nowicki",slug:"alexander-nowicki",email:"alexnowicki3@aim.com",position:null,institution:null},{id:"290332",title:"Dr.",name:"Natalie",middleName:null,surname:"Nowicki",fullName:"Natalie Nowicki",slug:"natalie-nowicki",email:"natalie.nowicki@pop.belmont.edu",position:null,institution:null},{id:"290333",title:"Prof.",name:"Stella",middleName:null,surname:"Nowicki",fullName:"Stella Nowicki",slug:"stella-nowicki",email:"President@nowickiinstitute.com",position:null,institution:null},{id:"290334",title:"Dr.",name:"Alfred",middleName:null,surname:"Samet",fullName:"Alfred Samet",slug:"alfred-samet",email:"dr.alfredsamet@gmail.com",position:null,institution:null},{id:"290335",title:"Dr.",name:"Roger",middleName:null,surname:"Su",fullName:"Roger Su",slug:"roger-su",email:"rwsumd@acraef.org",position:null,institution:null},{id:"290336",title:"Dr.",name:"James K.",middleName:null,surname:"Fortson",fullName:"James K. Fortson",slug:"james-k.-fortson",email:"jkfortson1@gmail.com",position:null,institution:null},{id:"294104",title:"Dr.",name:"Michał",middleName:null,surname:"Michalik",fullName:"Michał Michalik",slug:"michal-michalik",email:"michalim@wp.pl",position:null,institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Is CRS directly caused by infectious agents?",level:"2"},{id:"sec_3",title:"2. Is a healthy sinus cavity free of bacteria?",level:"1"},{id:"sec_3_2",title:"2.1 Alternative thesis: CRS involves direct bacterial infection",level:"2"},{id:"sec_5",title:"3. Finding E. coli in patients chronically ill with sinusitis",level:"1"},{id:"sec_5_2",title:"3.1 Genetic analysis discover highly pathogenic E. coli in CRS",level:"2"},{id:"sec_7",title:"4. Future studies",level:"1"},{id:"sec_8",title:"5. Considerations and conclusions",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"},{id:"sec_9",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Kennedy JL, Borish L. Chronic rhinosinusitis and antibiotics: The good, the bad, and the ugly. The American Journal of Rhinology and Allergy. 2013;27(6):467-472. DOI: 10.2500/ajra.2013.27.3960'},{id:"B2",body:'Antunes MB, Feldman MD, Cohen NA, Chiu AG. Dose-dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis. American Journal of Rhinology. 2007;21:423-427'},{id:"B3",body:'Abreu NA, Nagalingam NA, Song Y, Roediger FC, Pletcher SD, Goldberg AN, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Science Translational Medicine. 2012;4:151ra124'},{id:"B4",body:'Ma B, Forney LJ, Ravel J. Vaginal microbiome: Rethinking health and disease. Annual Review of Microbiology. 2012;66:371-389. DOI: 10.1146/annurev-micro-092611-150157'},{id:"B5",body:'Michalik M, Samet A, Marszałek A, Krawczyk B, Kotłowski R, Nowicki A, et al. Escherichia coli that carry fimG/H, fyuA and agn43 genes coding biofilm formation. 2018;13(3):e0192899. DOI: 10.1371/journal.pone.0192899.e. Collection 2018'},{id:"B6",body:'Rana T, Hasan RJ, Nowicki S, Venkatarajan MS, Singh R, Urvil PT, et al. Complement protective epitopes and CD55-microtubule complexes facilitate the invasion and intracellular persistence of uropathogenic Escherichia coli. Journal of Infectious Diseases. 2014;209(7):1066-1076'},{id:"B7",body:'Uren B, Psaltis A, Wormald PJ. Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis. Laryngoscope. 2008;118:1677-1680'},{id:"B8",body:'Jervis-Bardy J, Boase S, Psaltis A, et al. A randomized trial of mupirocin sinonasal rinses versus saline in surgically recalcitrant staphylococcal chronic rhinosinusitis. 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Familial risk of chronic rhinosinusitis with and without nasal polyposis: Genetics or environment. International Forum of Allergy and Rhinologyis. 2015;5(4):276-282'},{id:"B15",body:'Soler ZM, Mace JC, Litvack JR, Smith TL. Chronic rhinosinusitis, race, and ethnicity. American Journal of Rhinology and Allergy. 2012;26(2):110-116'},{id:"B16",body:'Lam K, Schleimer R, Kern RC. The etiology and pathogenesis of chronic rhinosinusitis: A review of current hypotheses. Current Allergy and Asthma Reports. 2015;15(7):41'},{id:"B17",body:'Stephenson MF, Mfuna L, Dowd SE. Molecular characterization of the polymicrobial flora in chronic rhinosinusitis. Journal of Otolaryngology–Head and Neck Surgery. 2010;39:182-187'},{id:"B18",body:'Stressmann FA, Rogers GB, Chan SW. Characterization of bacterial community diversity in chronic rhinosinusitis infections using novel culture-independent techniques. The American Journal of Rhinology and Allergy. 2011;25:e133e140'},{id:"B19",body:'Hamad WA, Matar N, Elias M. Bacterial flora in normal adult maxillary sinuses. American Journal of Rhinology and Allergy. 2009;23:261-263'},{id:"B20",body:'Nowicki B, Sledzinska A, Samet A, Nowicki S. Pathogenesis of gestational UTI: Urinary obstruction vs. immune adaptation and microbial virulence. BJOG: An International Journal of Obstetrics and Gynaecology. 2011;118(2):109-112'},{id:"B21",body:'Nowicki B. In vitro models for the study of uropathogens. In: Mobley HLT, Warren JW, editors. Urinary Tract Infection: Molecular Pathogenesis to Clinical Management. Washington, DC: American Society for Microbiology; 1996. pp. 341-376'},{id:"B22",body:'Spaulding CN, Hultgren SJ. Adhesive pili in UTI pathogenesis and drug development. Pathogens. 2016;5(1):30. ASM Press. pp. 341-369'},{id:"B23",body:'Kremer B, Jacobs JA, Soudijn ER, Johannes A, van der Ven AM. Clinical value of bacteriological examinations of nasal and paranasal mucosa in patients with chronic sinusitis. European Archives of Oto-Rhino-Laryngology. 2001;258(5):220-225'},{id:"B24",body:'AlMutairi D, Kilty SJ. Bacterial biofilms and pathophysiology of chronic rhinosinusitis. Current Opinion in Allergy and Clinical Immunology. 2011;11:18-23'},{id:"B25",body:'Foreman A, Psalitis AJ, Tan LW, Wormald PJ. Characterization of bacterial and fungal biofilms in chronic rhinosinusitis. American Journal of Rhinology and Allergy. 2009;23(6):556-561'},{id:"B26",body:'Ferguson BJ, Stolz DB. Demonstration of biofilm in human bacterial chronic rhinosinusitis. American Journal of Rhinology. 2005;19(5):452-457'},{id:"B27",body:'Kotłowski R, Bernstein CN, Sepehri S, Krause DO. High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut. 2007;56:669-675'},{id:"B28",body:'Johnson JR, Stell AL, Delavari P, Murray AC, Kuskowski M, Gaastra W. Phylogenetic and pathotypic similarities between Escherichia coli isolates from urinary tract infections in dogs and extraintestinal infections in humans. The Journal of Infectious Diseases. 2001;183:897-906'},{id:"B29",body:'Goluszko P, Moseley S, Truong LD, Kaul A, Nowicki S, Nowicki B. Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H—bearing Dr fimbriae: Mutation in the dra region prevented tubulointerstitial nephritis. The Journal of Clinical Investigation. 1997;99:1-11'},{id:"B30",body:'Kostakioti M, Hadjifrangiskou M, Hultgren SJ. Bacterial biofilms: Development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harbor Perspectives in Medicine. 2013;3(4):1-23'},{id:"B31",body:'Nowicki B, Vuopio-Varkila J, Viljanen P, Korhonen T, Makela PH. Fimbrial phase variation and systemic E. coli infection studied in mouse peritonitis model. 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Infection and Immunity. 1998;66:480-485'},{id:"B36",body:'Hancock V, Ferrières L, Klemm P. The ferric yersiniabactin uptake receptor FyuA is required for efficient biofilm formation by urinary tract infectious Escherichia coli in human urine. Microbiology. 2008;154(1):167-175'},{id:"B37",body:'Długaszewska J, Leszczyńska M, Lenkowski M, Tatarska A, Pastusiak T, Szyfter W. The pathophysiological role of bacterial biofilms in chronic sinusitis. European Archives of Oto-Rhino-Laryngology. 2016;273:1989-1994'},{id:"B38",body:'Ramadan HH, Sanclement JA, Thomas JG. Chronic rhinosinusitis and biofilms. Otolaryngology and Head and Neck Surgery. 2005;132:414-417'},{id:"B39",body:'Larson DA, Han JK. Microbiology of sinusitis: Does allergy or endoscopic sinus surgery affect the microbiologic flora? Current Opinion in Otolaryngology and Head and Neck Surgery. 2011;19:199-203'},{id:"B40",body:'Jain R, Waldvogel-Thurlow S, Darveau R, Douglas R. Differences in the paranasal sinuses between germ-free and pathogen-free mice. International Forum of Allergy and Rhinologyis. 2016;6(6):631-637'},{id:"B41",body:'Radtsig EY, Selkova EP, Malygina LV, Lapitskaia AS. The role of respiratory viruses in etiology of rhinosinusitis in the children. Vestnik Otorinolaringologii. 2014;6:39-40'},{id:"B42",body:'Beule AG. Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities and economic burden. Laryngo-Rhino-Otologie. 2015;94(Suppl 1):S1-S23'},{id:"B43",body:'Kaul A, Goluszko PG, Hart A, Martens M, Pham T, Nowicki S, et al. Rapid cycle changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae. Infection and Immunity. 1996;64:611-615'},{id:"B44",body:'Nowicki B, Nowicki S. CD55 as a therapeutic target for steroid hormones: Implications for host pathogen interaction: In: Lambris JD, Holers VM, Ricklin D, editors. 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Evaluation of a PCR melting profile technique for bacterial strain differentiation. Journal of Clinical Microbiology. 2006;44:2327-2332'},{id:"B53",body:'Clermont O, Bonacorsi S, Bingen E. Rapid and simple determination of the Escherichia coli phylogenetic group. Applied and Environmental Microbiology. 2000;66:4555-4558'},{id:"B54",body:'Adamus-Białek W, Wojtasik A, Majchrzak M, Sosnowski M, Parniewski P. (CGG)4 based PCR as a novel tool for discrimination of uropathogenic Escherichia coli strains: Comparison with enterobacterial repetitive intergenic consensus PCR. Journal of Clinical Microbiology. 2009;47:3937-3944'},{id:"B55",body:'Johnson JR, Brown JJ, Carlino UB, Russo TA. Colonization with and acquisition of uropathogenic Escherichia coli as revealed by polymerase chain reaction-based detection. The Journal of Infectious Diseases. 1998;177:1120-1124'},{id:"B56",body:'Krawczyk B, Śledzińska A, Piekarska A, Hellmann A, Kur J. Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia—Case report. Journal of Applied Genetics. 2017;58(3):415-418'},{id:"B57",body:'Nowak-Zaleska A, Wieczór M, Czub J, Nierzwicki Ł, Kotłowski R, Mikucka A, et al. Correlation between the number of Pro-Ala repeats in the EmrA homologue of Acinetobacter baumannii and resistance to netilmicin, tobramycin, imipenem and ceftazidime. Journal of Global Antimicrobial Resistance. 2016;7:145-149'},{id:"B58",body:'Mobley HLT, Alteri CJ. Development of a vaccine against Escherichia coli urinary tract infections. Pathogens. 2016;5(1):1'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Alexander Nowicki",address:null,affiliation:'
Washington University of Health and Science, Nowicki Institute for Women’s Health Research, USA
Nowicki Institute for Women’s Health Research, USA
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\n
1. Introduction
\n
In nature mercury is present in trace amounts only; due to its toxicity and the ability to join various natural cycles, it poses a threat to human health and life. Mercury exposure, even in small amounts, poses a threat to both people and the environment. A global study commissioned by United Nations Environment Programme (UNEP) confirmed the high environmental impact of mercury, entirely justifying the actions implemented to combat its spread on the international level. In recent years, the European Union has been systematically tightening standards for permissible mercury concentrations in atmospheric air.
\n
According to UNEP data, in 2015 the global emissions from anthropogenic sources amounted to 2220 tons of mercury, accounting for almost 30% of the total atmospheric emissions of mercury. The remaining 70% comes from environmental processes and contemporary natural sources [1]. The technological processes with the largest share in mercury emissions are gold production, 38%; coal combustion, 21%; nonferrous metallurgy, 15%; cement plants, 11%; waste incineration plants processing mercury-containing waste, 7%; and combustion of other fuels, including biomass, 3%. Analyzing data on mercury emissions in the respective continents, it can be stated that we find the highest ones in Asia, with about 1084 tons p.a.; in South America, about 409 tons p.a.; Sub-Saharan Africa, 360 tons p.a.; and in the European Union, with 77.2 tons p.a. [1]. Therefore, we can see that the processes of burning fossil fuels form one of the most significant sources of global atmospheric emissions of mercury.
\n
Research on Polish coals [2] demonstrates that the average mercury content in hard coal ranges from 50 to 150 ppb and 120 to 370 ppb in the case of lignite. For comparison, the mercury content of American coals is about 30–670 ppb, with the average content for hard coal of 70 and 118 ppb for lignite. The mercury content in furnace waste indicates that it is mainly found in fly ash and only a small part of it in slag. Literature data indicates that in the result of burning coal, approximately 30–75% of the mercury, contained in the fuel, will be released into the atmosphere [3].
\n
In the process of coal combustion, a number of chemical reactions occur that lead to the decomposition of all chemical compounds containing mercury. In the result of these processes, at a temperature above 600°C, only the metallic mercury Hg0 in the form of vapor will be present in the exhaust gas [4]. As the exhaust gas is cooled below 540°C [5], this mercury can be oxidized by gas phase components such as NO2, HCl, SO2, H2O, and fly ash, producing various compounds of mercury (Table 1).
\n
\n
\n
\n
\n
\n\n
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No.
\n
Name
\n
Symbol
\n
Boiling point
\n
\n\n\n
\n
1.
\n
Mercury
\n
Hg
\n
356.6°C
\n
\n
\n
2.
\n
Mercuric chloride
\n
HgCl2\n
\n
302.0°C
\n
\n
\n
3.
\n
Mercuric bromide
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HgBr2\n
\n
322.0°C
\n
\n
\n
4.
\n
Mercury(II) iodide
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HgI2\n
\n
354.0°C
\n
\n
\n
5.
\n
Mercurous oxide
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Hg2O
\n
Decomposes at >100°C
\n
\n
\n
6.
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Mercuric oxide
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HgO
\n
Decomposes at >500°C
\n
\n
\n
7.
\n
Mercury(I) carbonate
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Hg2CO3\n
\n
Decomposes at >130°C
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\n
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8.
\n
Mercury(II) nitrate
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Hg(NO3)2\n
\n
Melting point 79°C
\n
\n
\n
9.
\n
Mercury(II) sulfate
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HgSO4\n
\n
Decomposes before reaching liquid phase
\n
\n\n
Table 1.
Mercury compounds in flue gases from coal combustion processes.
\n
It was noticed that when burning coals containing significant amounts of chlorine, bromine, or iodine, the concentration of oxidized mercury increases with simultaneous decrease in concentration of metallic mercury. In the process of burning carbons containing chlorine, bromine, or iodine, the process of mercury oxidation is such that during this combustion salts containing chlorine, iodine or bromine is decomposed into HCl, HI, and HBr, whereby 0.5 ÷ 9% of these compounds are further decomposed to CL2, I2, and Br2. These react with metallic mercury to form HgCl2, HgBr2, and HgI2 salts, respectively, which are stable at high temperatures in vapor form. Oxidized mercury is removed from the flue gas both in dust collectors and in wet and semidry flue gas desulfurization units [6]. However, the efficiency of removal of metallic Hg0 in the aforementioned devices is low.
\n
The degree of the removal of mercury and its compounds depends mainly on the degree of transition of metallic mercury to oxidized mercury, with HgCl2 accounting for the main part of oxidized mercury. The value of Hg emissions depends on the combustion process and the method of exhaust gas purification; the mercury removal efficiency in an electrostatic precipitator is 30–40%, while in a wet desulfurization plant, as much as 80–90% of Hg2+ (divalent) mercury and mercury adsorbed by the solid phase will be removed, but in the case of elemental Hg0 mercury, far less is removed, with a removal efficiency of just 26.6% [3].
\n
The proportions between individual forms of mercury in the exhaust gas downstream the boiler depend mainly on the type of furnace and fuel characteristics (mercury, halides, and ash content of coal). The content of halides (fluorine, bromine, iodine, and chlorine) and mercury in fuel has the greatest impact on the amount of Hg2+, while the ash content determines the amount of Hg(p) [7]. For example, the proportions between elemental mercury, oxidized mercury, and ash-bound mercury in flue gas downstream of a pulverized coal boiler are on average 56% (8–94%), 34% (5–82%), and 10% (1–28%), respectively [7]. The type of furnace is not without significance for the mercury speciation in the exhaust gas. Circulating fluidized bed boilers generate the highest amount of Hg(p) (up to 65% of the so-called total mercury HgT defined as HgT = Hg0 + Hg2+ + Hg(p)) due to the extended contact time between gaseous mercury and fly ash and the low temperature of the exhaust gas downstream of the boiler [7].
\n
The European Commission (on July 31, 2017) established conclusions on the best available techniques (BAT) for large combustion plants (LCP). BAT conclusions tighten the regulations related to the emissions from combustion processes, including nitrogen and sulfur oxides, and introduce mercury emission limits (that were not present in the EU till that date). Table 2 contains the permissible concentrations of mercury and nitrogen oxides in the exhaust gas, resulting from the BAT conclusions. BAT conclusions include ranges of emission limit values for mercury and nitrogen oxides in exhaust gases, with maximum concentration values that will apply from 2021 onwards. Permissible mercury concentrations in exhaust gases resulting from BAT conclusions [8] are referred to as total mercury HgT. These values vary depending on the status of the source. For existing sources with a capacity of >300 MWt, they are 1–4 μg/m3\nUSR\n\n for hard coal and 1–7 μg/m3\nUSR\n\n for lignite. For new sources with a capacity of >300 MWt, they are 1–2 μg/m3\nUSR\n\n for hard coal and 1–4 μg/m3\nUSR\n\n for lignite. Concentrations are converted to standard USR means conditions: (dry gas at a temperature of 273.15 K and a pressure of 101.3 kPa, calculated for oxygen content in the flue gas O2 = 6 %).
BAT conclusions include the range of mercury emission limit values for exhaust gases while specifying maximum concentration values that will apply from August 18, 2021 onwards. The lower values indicate levels that can be obtained using best available techniques, and as long as these values are not required now, it can be expected that existing and new coal units will have to achieve them in near future [8]. This means that users of combustion plants should seek for methods to achieve lower emission levels resulting from the BAT conclusions. The implementation of BAT conclusions thus forms a significant challenge for coal energy in Europe and in particular for the Polish energy sector. The introduction of emission limits also necessitates the addition of HgT measurement devices to the pollution monitoring system [8].
\n
BAT conclusions also reduce the permissible levels of nitrogen oxides (NOx) emissions. For existing sources, fired with hard coal and lignite, with a capacity of >300 MWt, these amount to 85 (65)–150 mg/m3, and for new sources with a capacity of >300 MWt to 50 (65)–85 mg/m3 in standard conditions.
\n
The above provisions are associated with the need to implement selective catalytic reduction (SCR) and selective non-catalytic reduction (SNCR) techniques as well as other techniques, including integrated exhaust gas treatment (multipollutant technologies), in which a single device is applied to remove at least two pollutants. In this study, we would like to point to the possibility of such integrated flue gas treatment in absorbers of the wet flue gas desulfurization method. The wet limestone method is a common SO2 removal technology used in power plants both in Europe and worldwide. The desulfurization efficiency of this method ranges from 90 to 95%. This technology is also very popular in Polish conditions, accounting for some 90% of the desulfurization installations.
\n
\n
\n
2. Methods for reducing mercury emissions
\n
\n
2.1 Primary methods
\n
Enrichment of coal prior to the combustion process, e.g., by removing pyrite, can significantly reduce mercury emissions. It is estimated that 65–70% of mercury in Polish coals occurs in combination with pyrite.
\n
Coal enrichment methods are mainly based on physical separation of the mineral substance and involve the use of density differences (gravitational separation) or differences in the wettability of the components (flotation).
\n
One of the methods that do apply dry gravitational separation is the removal of pyrite in purpose-modernized coal mills. The technology is offered by Hansom [9].
\n
Primary methods also include changing the combustion process. For example fluidized bed furnaces to lower the exhaust gas temperature and ash grain composition or using of low emissions burners to lower exhaust gas temperature. Another solution is to replace the coal used for combustion and mixing high Hg and S content coals with those with lower contents of these elements [10]. What is also applied is the addition of halides, in the form of bromine, iodine, and chlorine salts, to the burning coal [11]. The oxidizing properties of these compounds contribute to the increase in the proportion of oxidized mercury in the exhaust gases, which in turn contributes to its more effective retention in existing aftertreatment devices. Unfortunately, these methods cannot guarantee the reduction of mercury to the level required by BAT conclusions.
\n
\n
\n
2.2 Secondary methods
\n
The degree of the removal of mercury and its compounds depends mainly on the degree of transition of metallic mercury to oxidized mercury. Secondary methods consist mainly of removing oxidized mercury adsorbed on ash particles or other adsorbent, e.g., activated carbon, in its form bound with particulates—Hg(p).
\n
An important group of secondary methods are the adsorptive mercury removal methods. They rely on binding of oxidized forms of mercury on the surface of adsorbents. What they use is the affinity of mercury vapors to various adsorbents. The most common adsorber is activated carbon in powdered form (powdered activated carbon). However, due to the limited efficiency of Hg0 reduction of this typical form of carbon, it is necessary to impregnate this medium with sulfur, iodine, chlorine, or bromine to improve the efficiency of mercury vapor retention. This increases the efficiency of mercury oxidation and its adsorption on PAC particles. Studies demonstrated that ordinary activated carbon can retain up to 80% of mercury in a higher oxidation state but only some 40–50% of elemental mercury. In contrast, carbon impregnated with sulfur, for example, adsorbs over 80% Hg0 and the iodine impregnated carbon virtually 100% [12].
\n
\n
2.2.1 Injection of activated carbon (PAC) in exhaust gases
\n
Activated carbon is usually injected into the exhaust gas duct before the ESP or fabric filter (Figure 1). This technology is used in waste incineration facilities and coal-fired power plants. The effectiveness of this method depends primarily on the type and structure of PAC, the chemical properties of the sorbent surface, the amount of injected coal, and the temperature of the exhaust gas. The main disadvantage of this technology is the increase in the carbon content of ash, which significantly limits the possibilities of ash utilization. Sometimes it can also reduce dust collection efficiency, especially when particles of submicron scale are considered.
\n
Figure 1.
Diagram of activated carbon injection technology upstream of the ESP; APH—air heater and FGD—flue gas desulfurization installation.
\n
To tackle this issue, activated carbon injection downstream the ESP and further exhaust gas purification in the fabric filter are applied (Figure 2). However, this makes it necessary to dispose ash from two different locations [13].
\n
Figure 2.
Diagram of activated carbon injection technology downstream of the ESP; APH—air heater and FGD—flue gas desulfurization installation.
\n
Another solution for the injection of activated carbon into exhaust gases is the sorbent injection upstream the air preheater into the zone with a much higher temperature than in the solutions used so far downstream the air preheater or the electrostatic precipitator, i.e., the Alstom Mer-Cure™ technology [14] (Figure 3).
\n
Figure 3.
Diagram of the Mer-Cure™ technology for activated carbon injection; APH—air heater and FGD—flue gas desulphurization installation.
\n
\n
\n
2.2.2 The use of systems for catalytic reduction of nitrogen oxides (SCR) for the oxidation of mercury
\n
It was found, based on the research, that in flue gas denitrification installations based on the selective catalytic reduction method, the oxidation of Hg0 mercury to Hg2+ form occurs. The condition for this process, however, is the appropriate chlorine content in the flue gas. Typically, for hard coal, this content proves sufficient to trigger the oxidation process. Important for this process is the fact that the denitrification and oxidation reactions of mercury cannot occur simultaneously, because they depend on the same active centers. Research in industrial conditions indicates that the achievable degree of mercury oxidation is up to 78% [15].
\n
When lignite is burned, the absence of chlorine in the flue gas causes oxidation reactions not to occur. In this case, NH4Cl injection upstream of the SCR catalyst is proposed to allow mercury oxidation in the catalyst (Figure 4). NH4Cl or NH4OH injection takes place in a zone with a temperature of about 370–420°C, and then activated carbon is added to the exhaust gas, after which the exhaust gas is directed to a dust collector (ESP or fabric filter), and finally to the absorber of the wet desulfurization method [16].
\n
Figure 4.
Diagram of mercury emission reduction technology for lignite-fired boilers: SCR—catalytic flue gas denitrification reactor; APH—air heater; and FGD—flue gas desulphurization installation.
\n
\n
\n
2.2.3 Injection of oxidizing additives and the use of fly ash as the adsorbent
\n
Based on numerous studies [17, 18, 19, 20, 21, 22, 23], it was found that with use of chloride additives, it is possible to achieve high efficiency of mercury vapor adsorption on ordinary activated carbon or other sorbents (fly ash) [12, 24].
\n
The proposed method involves the injection of aqueous additive solutions based on chlorite and/or potassium permanganate into the exhaust duct upstream the electrostatic precipitator [25] (Figure 5).
\n
Figure 5.
Diagram of liquid additive injection technology upstream of the ESP: APH—air heater and FGD—flue gas desulphurization installation.
\n
The degree of mercury oxidation in this technology depends on numerous parameters; the most important of them are flue gas temperature; flue gas composition, including the SO2, SO3, and NO concentrations; pH; and the chemical composition of fly ash. The main oxidized mercury compounds are HgO and Hg (NO3)2. Part of the oxidized mercury is adsorbed on fly ash particles and as Hg(p) is removed with dust in the ESP unit. The remaining Hg2+ mercury in gaseous form is retained in the WFGD absorber and is removed along with the wastewater.
\n
\n
\n
\n
2.3 Removal of oxidized mercury in flue gas purification devices
\n
\n
2.3.1 Removal of mercury in electrostatic precipitators
\n
Tests of mercury content in fly ash upstream of the electrostatic precipitator demonstrate that it is several times higher than the mercury content of coal, which indicates a high sorption capacity of fly ash [26, 27]. The mechanism of mercury adsorption is as follows: in the boiler (temperature of above 1400°C), mercury is in the form of metallic mercury vapors, while the chlorine (HCl) contained in the flue gas activates carbon particles in the ash, and as the flue gas cools down, Hg0 adsorbs in the chlorinated carbon pores and undergoes oxidation. If there is no HCl (HBr, HI) in the flue gas, there is also no Hg0 sorption on the ash particles, and the sorption of oxidized HgCl2 mercury is also low.
\n
Research on mercury content in fly ash from hard coal combustion in both pulverized coal and grate boilers indicates a higher Hg content in fine grains. In Figure 6 we present the results of mercury content testing in individual fractions of fly ash grains from a pulverized coal boiler.
\n
Figure 6.
Mercury content in individual fractions of fly ash from an OP-230 pulverized coal boiler.
\n
The sorption of mercury and its compounds depends significantly on the flue gas temperature and the content of unburned carbon in fly ash particles. Thus, the removal efficiency of mercury and its compounds increases with the mercury oxidation efficiency and the increased dust removal efficiency, especially of fine particles.
\n
\n
\n
2.3.2 Removal of mercury in desulphurization installations
\n
\n
2.3.2.1 Mercury removal in absorbers of wet flue gas desulfurization installations
\n
Oxidized mercury compounds contained in the flue gas (mainly the HgCl2) are removed in FGD absorbers, whereas the Hg2+ reacts with the sulfides in the exhaust gas, e.g., with H2S, to form mercury sulfide HgS, which is then precipitated. We also know the phenomenon of mercury re-emission from flue gas desulfurization absorbers. If the sulfide content in the suspension is too low, a chemical reduction of Hg2+ to Hg0 may occur, resulting in higher concentration of metallic mercury downstream the absorber than upstream of it.
\n
It is assumed that the efficiency of removing oxidized mercury in FGD absorbers reaches a value of up to 70%, while it can happen that almost all the oxidized mercury is removed in a dust collector, with only the metallic mercury reaching the absorber [6]. In this case, it is recommended to directly introduce oxidizing additive to the main FGD cycle [28].
\n
\n
\n
2.3.2.2 Removal of mercury in semidry flue gas desulfurization installations
\n
In semidry installations, the desulfurization process of the desulfurization reaction products (waste) remains dry. This process is implemented either by spraying lime milk in the upper part of the reactor (spray dryer) or using the so-called pneumatic reactor, where the sorbent and water are separately fed in its lower part. The resulting dry waste is most often recirculated, and the exhaust gases are dedusted in a fabric filter. The long residence time of sorbent particles in the reactor and the flow of exhaust gas through the filter cake in the bag filter allow for the additional benefit of removing quite a number of impurities, including mercury, provided that an appropriate sorbent is selected.
\n
The semidry method using a pneumatic reactor integrated with a fabric filter for desulfurization of flue gas demonstrated a significant mercury removal efficiency of about 96%, when feeding additional activated carbon together with the primary sorbent (hydrated lime) [29].
\n
\n
\n
\n
\n
\n
3. Methods for reducing nitrogen oxides (NOx)
\n
Methods for reducing nitrogen oxides from coal combustion in power plants can be divided into two main groups, i.e., the primary and secondary methods. Primary methods rely on the organization of the combustion process in the chamber, primarily through the use of low-emission burners, air staging, exhaust gas recirculation, or reduction of the combustion temperature (fluidized bed boilers). The second group of methods is the secondary method, i.e., the selective catalytic and non-catalytic reduction and oxidative methods.
\n
The latter group of secondary methods is applied in the integrated flue gas cleaning process. The basis for the operation of oxidative methods is the oxidation of sparingly soluble impurities in exhaust gases, i.e., nitric oxide and mercury to soluble forms, and their removal together with SO2 by means of absorption or condensation [30]. There are many oxidants that are applied in oxidative methods. The most recommended oxidizing agents are ozone (O3), hydrogen peroxide (H2O2), and numerous compounds of chlorine (NaClO, NaClO2, Ca(ClO)2, ClO2) [31]. Whenever a gaseous oxidant is used, it may be fed directly to the flue gas duct; in the case of liquid oxidants, the conditions necessary for their evaporation should be provided, or, alternatively, they can be used as an additive to the sorption liquid in the absorber [18]. Comparison of the oxidizing potential of individual oxidants with respect to oxygen is presented in Table 2.
\n
As you can see, ozone has the highest oxidation potential, and it has the valuable advantage in that it enables oxidation of NO and NO2 to higher nitrogen oxides, while other oxidants oxidize it predominantly to NO2 only [31]. The fact that oxidation occurs in the gas phase, which affects the increase in reaction rate, is also significant. Oxidation methods allow for the simultaneous removal of nitrogen oxides, sulfur dioxide, and mercury from flue gases in a single installation, with an efficiency exceeding 90%. Due to the lower operating and investment costs, they form an alternative to the commonly used combination of SCR and FGD. The presence of dust in the flue gas affects the amount of oxidizer used, and therefore a high-performance dust collector should be used upstream of the installation. In the case of commercial pollutant removal installations, ozone is the main oxidizer used for nitrogen oxides. Removal of the reaction products of nitrogen oxides with ozone takes place by means of absorption, for example, by the Lextran [32, 33] and LoTOx methods [34, 35, 36]. In Lextran method ozone is added to the flue gas before the absorber feed by mixture of water and catalyst. In LoTOx method, ozone is introduced before FGD absorber.
\n
Another solution is to reduce pollution from flue gas with liquid oxidants. It involves their introduction into flue gas upstream of the wet or semidry flue gas desulphurization installations. Their task is to oxidize both the nitrogen oxide to NO2 and the metallic mercury to Hg2+. In the case of wet flue gas desulfurization installations, liquid oxidants may also be added to the sorption liquid tank. Hydrogen peroxide [37] is a very popular oxidant used in industry, having the valuable advantage in that it is not as harmful to the environment as chlorine compounds and, at the same time, it is relatively cheap. Exhaust gas treatment with hydrogen peroxide is an extremely promising process. Many researchers around the world are working to improve its effectiveness in relation to the oxidation of nitrogen oxides. Works are carried out on combining the dosing of hydrogen peroxide with metal oxides [38], activating hydrogen peroxide using ultraviolet rays [39], combining H2O2 injection with catalysts (Fe-Al, Fe2O3, Fe-Ti) promoting the formation of OH* radicals [40], and using a combination of two oxidants, e.g., H2O2/NaClO2 [41]. The results of these experiments are all very promising, and we can expect that future industrial flue gas cleaning installations will apply the presented processes. The achieved efficiency of NOx and Hg removal from the carrier gas, at least in lab scale tests, is at the level of 90% [42]. Work on the use of sodium chlorite was also carried out on a laboratory and pilot scale [43]. It achieved a removal efficiency of 99% for SO2 and Hg and 90% for NOx.
\n
\n
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4. Technologies for simultaneous removal of HgT and NOx: authors’ own research
\n
As already mentioned, the efficiency of mercury removal in flue gas cleaning installations depends on the speciation of mercury, and the mercury present in the flue gas occurs in both the Hg0 and the Hg2+ forms. Hg2+ oxidation increases with the increase in the content of halides (chlorides, bromides, and iodides) in carbon. In the absence of a natural oxidant, as is the case with lignite, liquid oxidative additive can be used for Hg0 oxidation. Absorbers of the wet flue gas desulfurization plant capture mercury in the Hg2+ gas form. In the result of cooperation between the Wrocław University of Technology and Rafako S.A., we developed an Hg emission reduction technology dedicated for hard coal and lignite-fired units. The method involves the injection of sodium chlorite into the exhaust duct upstream the WFGD absorber. In the result of injection of the oxidant, Hg0 is oxidized to Hg2+ and NO to NO2, and these oxidation products are captured from the flue gas together with SO2 in the WFGD absorber. The technology has been tested on an industrial scale in a 400 MWe lignite-fired unit.
\n
\n
4.1 Research on the impact of injection of oxidizer in exhaust gases on the efficiency of Hg and NOx reduction
\n
The tests were carried out using exhaust gases from a lignite-fired dust boiler (400 MWe) equipped with a selective non-catalytic NOx reduction installation, an electrostatic precipitator, and a wet flue gas desulfurization installation. The WFGD absorber is equipped with four levels of sprinkling and a system for feeding adipic acid into the suspension in order to increase the desulfurization efficiency. The test installation for injection of oxidizer (sodium chlorite) was built between the exhaust fan and the fan supporting the WFGD installation. The choice of the additive injection site upstream the booster fan guaranteed very good mixing of the additive with exhaust gases. The mercury content of the fuel during the tests varied between 0.215 and 0.701 mg/kg. A diagram of the installation, along with the location of the measuring points, is shown in Figure 7 [44].
\n
Figure 7.
Diagram of the research installation during tests on lignite flue gas. (A) Measuring cross section before oxidant injection. (B) Measuring cross section downstream the injection site. (C) Measuring cross section in the chimney.
\n
As part of the research, we performed continuous measurements of mercury concentration in exhaust gases (using two Gasmet mercury emission monitoring systems) in measuring cross sections located upstream the injection site (A) and in the chimney (C); we carried additional measurements of mercury speciation by the manual method (Ontario-Hydro) at the chimney (C), upstream the WFGD absorber (B), and upstream the oxidative additive injection site (A). Based on the continuous measurements of mercury concentration in the exhaust gas upstream of the absorber and in the chimney, the efficiency of removing mercury from the exhaust gas in the WFGD absorber was calculated with the following formula:
where HgT\nC is the mean total mercury concentration in the flue gas in the chimney (C), μg/m3\nUSR; and HgT\nA is the mean total mercury concentration in the exhaust gas upstream of the absorber (A), μg/m3\nUSR.
\n
To determine the NO to NO2 oxidation degree in a given measurement cross section, the volumetric share of NO2 in the flue gas in relation to the sum of nitric oxide and nitrogen dioxide (NOx) was determined. The NO to NO2 oxidation degree was calculated by means of the relations:
where NO2\nB is the NO2 concentration in the flue gas in the measurement cross section (B), ppm; and NOx\nB is the NOx concentration in the flue gas in the measurement cross section (B), ppm.
\n
The effectiveness of NOx removal from the flue gas in the FGD absorber was determined based on the measurement of NOx concentration (sum of NO and NO2 calculated as NO2 [45]) in the cross section located in the chimney (C) and upstream the FGD absorber (A). The NOx removal efficiency was determined by means of the relation:
where NOx\nA is the average NOx concentration in the flue gas upstream the absorber (A), mg/m3\nUSR; and NOx\nC is the average NOx concentration in flue gas in the chimney (C), mg/m3\nUSR.
\n
To specify the number of moles of the oxidant to be applied in relation to the moles of nitrogen oxide in the flue gas, a molar ratio \n\nX\n\n was introduced:
Calculation of the molar ratio X was made for the concentration of NO in the flue gas measured in the chimney (C) in the period immediately prior to the oxidant injection.
\n
When the aqueous solution of sodium chlorite is sprayed in the flue gas upstream the absorber, first it evaporates (the temperature of the flue gas during the tests at the oxidant injection site (A) varies from 165 to 170°C) as a result of the reaction of gaseous sodium chlorite (initial pH of sodium chlorite solution was 11.5) with nitric oxide, nitrogen dioxide, and sodium chloride being formed [46]:
Due to the significant share of moisture in the flue gas (from 28 to 29%), there were very good conditions for the formation of nitric and nitrous acids [47]:
The nitric acid formed in the flue gas reacted with the metallic mercury and oxidized it to the form Hg2+ (mercury(II) nitrate), which increases HgT removal efficiency from flue gas [43, 46]:
Because flue gas contains acidic gases such as SO2, HCl, and HF, they can be absorbed by oxidant droplet and drop its pH before evaporation which caused the release of ClO2 [48]. Chlorine dioxide can directly oxidized NO and Hg0; additionally emission of chlorine radical is possible, which enhanced Hg0 oxidation [15, 19]:
In such a complicated gas mixture as flue gases from lignite combustion, the presented mechanism can occur simultaneously. For example, the efficiency of NO to NO2 oxidation and the removal of HgT and SO2 during the tests carried out in a lignite-fired power plant (sodium chlorite fed to the exhaust gas prior to the FGD absorber) are shown in Figure 8.
\n
Figure 8.
Oxidation NO to NO2, NOx, SO2, and HgT removal efficiency in function of molar ratio X.
\n
The efficiency of HgT removal and oxidation of nitrogen oxides in exhaust gases depend on the stream of injected sodium chlorite to exhaust gases, which is illustrated by the molar ratio X. Changes in total mercury concentration in exhaust gases in the chimney (C) and NO, NO2, and NOx downstream the sodium chlorite injection site (B) are illustrated in Figure 9. The undoubted advantage of the presented method is the almost immediate reaction of the entire system to the injected sodium chlorite. An increase in the amount of injected additive (series I < series II) causes an immediate decrease in the HgT concentration in the chimney and an increase in the NO2 concentration in the exhaust gas downstream the injection site. The HgT concentration in the chimney during the presented tests was below the level required by the BAT conclusions, i.e., <7 μg/m3\nUSR.
\n
Figure 9.
NO, NO2, and NOx concentrations in the flue gas downstream the injection site (B) and HgT concentration in the chimney (C).
\n
Sodium chlorite injection into flue gas upstream of the WFGD absorber caused an increase in Hg2+ concentration in the flue gas, which translated into the efficiency of mercury removal. Unfortunately, in some cases, the increase in Hg2+ concentration in the exhaust gas intensified the phenomenon of re-emission [44].
\n
\n
\n
4.2 Increased Hg removal efficiency by limiting re-emissions
\n
The phenomenon of re-emission consists in chemical reduction of the Hg2+ absorbed in the suspension to the elemental Hg0 mercury emitted back into the atmosphere [49]. Sulfite ions (SO3\n2−), acting as a reducing agent, are responsible for this phenomenon [50]:
In FGD installations, where the addition of organic acids (formic, adipic and other) serves increasing the \n\n\nSO\n2\n\n\n removal efficiency, the following reaction takes place (14) [50]. Dosing organic acids increases the concentration of Ca2+, which improves the efficiency of SO2 removal from the exhaust gases. Many researchers also reported the clear effect of sulfite concentration in the suspension on Hg0 re-emission. Generally, an increase in SO3\n2− concentration increases the re-emission [51, 52, 53].
\n
The re-emission phenomenon is assessed on the basis of measurements of mercury concentration in exhaust gas both upstream and downstream the WFGD absorber. In order to find out the nature of the re-emission phenomenon, research was carried out on a lignite-fired unit. We assumed that the concentration of total mercury in the cross section (C) was higher than in the cross section (B) the phenomenon of mercury re-emission from the FGD absorber was present, and the intensity of this phenomenon was described using re-emission rate:
An example of variations in total mercury concentration in exhaust gases in the period when re-emission occurred is presented in Figure 10.
\n
Figure 10.
Total mercury concentrations in flue gas upstream the WFGD absorber (B) and in the chimney (C).
\n
The observed phenomenon of mercury re-emission from the absorber lasted for approx. 4 h. Based on the analysis of the presented graphs, we calculated the degree of mercury re-emission according to Eq. (5); the calculation results are presented in Figure 11.
\n
Figure 11.
The degree of mercury re-emission from the WFGD absorber during measurements for a lignite-fired unit.
\n
The observed degree of re-emission from the WFGD absorber reached 220%. In order to explain the mechanisms of this phenomenon, the results of the re-emission degree were compared with the operating parameters of the unit and the WFGD (Figure 12). Mercury re-emission occurred when the absorber operating parameters changed, and the pH and ORP proved to be the most significant of them. A detailed description of the parameters affecting the intensity of the phenomenon of re-emission from the WFGD absorber is presented in the publication [44].
\n
Figure 12.
Parameters of unit and WFGD absorber operation during measurements for a lignite-fired unit.
\n
Research demonstrated that re-emission can be reduced by changing the absorber’s operating parameters. We noticed that an increase in suspension temperature and pH increased re-emission, while the increase in chloride concentration in the suspension and the intensity of air flow through the suspension reduced it [54]. At the same time, numerous studies indicate that significant reductions of Hg0 re-emission can be obtained by adding various additives [53, 54, 55]. The most common are simple additions of \n\nNaHS\n\n and \n\n\nNa\n2\n\nS\n\n organic sulfides with a more complex structure. The goal is always the same, i.e., to remove from the solution (suspension) Hg2+ by formation \n\nHgS\n\n, which prevents re-emission. The effect of adding sodium sulfide (Na2S) to the suspension circulation in the WFGD absorber was studied for a lignite-fired unit, and the results are presented in Figure 13. 4 m3 of 10% solution of sodium sulfide were pumped directly into the tank under the absorber. In this way, the mercury concentration in the exhaust gas was reduced below the level required by the BAT conclusions (7 μg/m3\nUSR) for a period of approx. 4 h.
\n
Figure 13.
Total mercury concentration in the chimney and upstream the WFGD absorber after a one-time injection of 4m3 of sodium sulfide (10%).
\n
The phenomenon of mercury re-emission from the WFGD absorber is not always identifiable on the basis of measurements of total mercury concentration in exhaust gases. Hard coal tests were carried out for the WFGD absorber, purifying flue gas from two units with a capacity of 195 and 220 MWe. During the tests, both boilers operated at maximum power. Prior to the tests, measurements were performed with the Ontario-Hydro method revealing that the absorber is experiencing metallic mercury re-emission. The results of these measurements are presented in Figure 14.
\n
Figure 14.
Comparison of mercury concentration in flue gas for hard coal tests.
\n
The total mercury removal efficiency in the flue gas treatment installation (electrostatic precipitator and WFGD) was 72.4%. Mercury bound with the ash was virtually completely removed in the ESP. The flue gas downstream of the boiler contained a small amount of metallic mercury only (1.73 μg/m3\nUSR), which was a result of the high concentrations of halides in the fuel (Cl (0.110 ÷ 0.211%), Br (0.008 ÷ 0.011%), F (0.002 ÷ 0.004%)). The concentration of metallic mercury in the exhaust gas upstream of the absorber was lower than downstream the absorber, which meant that the absorber was the source of mercury re-emission. The total mercury removal efficiency in the ESP was 56.2% and another 36.9% in the WFGD absorber. Due to the fact that the proportion of oxidized mercury upstream the WFGD absorber is significant, sodium sulfide was fed to the absorber to reduce mercury emissions in the flue gas in the chimney. In Figure 15, we present the results of measurements of mercury concentration in exhaust gas upstream and downstream the WFGD absorber, during dosing of sodium sulfide. Measurements were carried out with two continuous emission monitoring systems and the Ontario-Hydro method.
\n
Figure 15.
Measurement results of mercury concentration in flue gas upstream and downstream the WFGD absorber (continuous and Ontario-Hydro measurements) during the addition of Na2S.
\n
The total mercury concentration in the exhaust gas before the administration of sodium sulfide was 4.3 μg/m3\nUSR, and after the addition of sodium sulfide, the concentration of total mercury in the exhaust gas dropped to 0.45 μg/m3\nUSR. The mercury removal efficiency for the exhaust gas in the WFGD absorber amounted to 25.5% without the addition of sulfide and increased to 90.5% after applying the additive. To sum up, due to the content of halides in coal, a considerable amount of Hg2+ is present in hard coal exhaust gas, which can be effectively removed in WFGD, as long as the phenomenon of re-emission is controlled.
\n
\n
\n
\n
5. Summary
\n
The chapter presents selected issues related to Hg and NOx emissions from coal combustion processes, in the aspect of regulations related to limiting permissible emissions of pollutants, as contained in the BAT conclusions. The review of methods applied to reduce mercury emissions demonstrates that the specific technology should be selected individually for each facility considered. There is no single, universal, cost-effective solution. In order to choose an effective method for reducing mercury emissions, it is first and foremost necessary to hold the knowledge of the speciation of mercury in the exhaust gas downstream the boiler. In the case of low concentration of oxidized mercury, there are no devices that can be installed in order to secure sufficient limiting of mercury emissions. In such a case, one should first consider the solutions that consist in supplementing the exhaust gas with additives to oxidize the metallic mercury first.
\n
Among the methods used for denitrification of exhaust gases, attention has been given to oxidative methods, which form an opportunity to simultaneously reduce NOx and Hg emissions. The results of the author’s own research in industrial conditions confirmed the usefulness of injection of the oxidant (sodium chlorite) to the exhaust gas upstream the WFGD absorber to reduce mercury emission. Under favorable conditions for lignite flue gases, up to 70% Hg removal efficiency was achieved, coupled with 17% NOx removal efficiency and an unchanged SO2 removal efficiency. Whenever there is the phenomenon of re-emission of mercury from the WFGD absorber, appropriate measures must be undertaken to limit it. Again, test results on lignite and hard coal exhaust gas indicate that it is possible to reduce re-emissions to such an extent, as to ensure compliance with emission standards in line with BAT conclusions.
\n
By using mercury oxidation technologies with simultaneous application of flue gas purification devices (DeNOx, DeSOx, and dedusting) and effectively combating re-emissions, we can achieve total mercury concentrations at the level required by BAT conclusions, i.e., in the order of 1–7 (4) μg/m3\nUSR.
\n
\n
\n
List of abbreviations
\n
\n\n\nAPH\n\n
air (pre)heater
\n\n\n\nBAT\n\n
best available techniques
\n\n\n\nESP\n\n
electrostatic precipitator
\n\n\n\nFGD\n\n
flue gas desulphurization
\n\n\n\nPAC\n\n
powdered activated carbon
\n\n\n\nSCR\n\n
selective catalytic reduction
\n\n\n\nWFGD\n\n
wet flue gas desulphurization
\n\n\n\n
\n
\n\n',keywords:"Hg emissions, NOx emissions, combustion, industrial pollution, heavy metals",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/72129.pdf",chapterXML:"https://mts.intechopen.com/source/xml/72129.xml",downloadPdfUrl:"/chapter/pdf-download/72129",previewPdfUrl:"/chapter/pdf-preview/72129",totalDownloads:146,totalViews:0,totalCrossrefCites:0,dateSubmitted:"December 19th 2019",dateReviewed:"March 31st 2020",datePrePublished:"May 11th 2020",datePublished:"January 7th 2021",dateFinished:"May 11th 2020",readingETA:"0",abstract:"The chapter presents the issue of reducing mercury and nitrogen oxides emissions from the flue gas of coal-fired boilers. The issue is particularly relevant due to the stricter regulations regarding exhaust gas purity. A brief review of the methods for reducing Hg and NOx emissions has been made, pointing out their pros and cons. Against this background, the results of the authors’ own research on the injection of selected oxidants into flue gases to remove both of these pollutants are presented. The injection of sodium chlorite solution into the flue gas (400 MWe lignite fired unit) upstream the wet flue gas desulphurization (WFGD) absorber contributed to the oxidation of both metallic mercury and nitric oxide and enhanced their removal efficiency. The results of tests on lignite and hard coal flue gases indicate that in order to reduce the unfavorable phenomenon of mercury re-emission from WFGD absorbers, in some cases, it is necessary to add selected chemical compounds (e.g., sulfides) to the desulfurization system. The results of field tests for flue gas from lignite (400 MWe unit) and hard coal-fired boilers (195 and 220 MWe units) confirmed the usefulness of oxidizer injection technology to reduce mercury emissions below the level required by BAT conclusions.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/72129",risUrl:"/chapter/ris/72129",signatures:"Maria Jędrusik, Dariusz Łuszkiewicz and Arkadiusz Świerczok",book:{id:"10178",title:"Environmental Emissions",subtitle:null,fullTitle:"Environmental Emissions",slug:"environmental-emissions",publishedDate:"January 7th 2021",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/10178.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"103742",title:"Dr.",name:"Richard",middleName:null,surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"317074",title:"Prof.",name:"Maria",middleName:null,surname:"Jedrusik",fullName:"Maria Jedrusik",slug:"maria-jedrusik",email:"maria.jedrusik@pwr.edu.pl",position:null,institution:null},{id:"317075",title:"Dr.",name:"Dariusz",middleName:null,surname:"Luszkiewicz",fullName:"Dariusz Luszkiewicz",slug:"dariusz-luszkiewicz",email:"dariusz.luszkiewicz@pwr.edu.pl",position:null,institution:null},{id:"317076",title:"Prof.",name:"Arkadiusz",middleName:null,surname:"Swierczok",fullName:"Arkadiusz Swierczok",slug:"arkadiusz-swierczok",email:"arkadiusz.swierczok@pwr.edu.pl",position:null,institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Methods for reducing mercury emissions",level:"1"},{id:"sec_2_2",title:"2.1 Primary methods",level:"2"},{id:"sec_3_2",title:"2.2 Secondary methods",level:"2"},{id:"sec_3_3",title:"2.2.1 Injection of activated carbon (PAC) in exhaust gases",level:"3"},{id:"sec_4_3",title:"2.2.2 The use of systems for catalytic reduction of nitrogen oxides (SCR) for the oxidation of mercury",level:"3"},{id:"sec_5_3",title:"2.2.3 Injection of oxidizing additives and the use of fly ash as the adsorbent",level:"3"},{id:"sec_7_2",title:"2.3 Removal of oxidized mercury in flue gas purification devices",level:"2"},{id:"sec_7_3",title:"2.3.1 Removal of mercury in electrostatic precipitators",level:"3"},{id:"sec_8_3",title:"2.3.2 Removal of mercury in desulphurization installations",level:"3"},{id:"sec_8_4",title:"2.3.2.1 Mercury removal in absorbers of wet flue gas desulfurization installations",level:"4"},{id:"sec_9_4",title:"2.3.2.2 Removal of mercury in semidry flue gas desulfurization installations",level:"4"},{id:"sec_13",title:"3. Methods for reducing nitrogen oxides (NOx)",level:"1"},{id:"sec_14",title:"4. Technologies for simultaneous removal of HgT and NOx: authors’ own research",level:"1"},{id:"sec_14_2",title:"4.1 Research on the impact of injection of oxidizer in exhaust gases on the efficiency of Hg and NOx reduction",level:"2"},{id:"sec_15_2",title:"4.2 Increased Hg removal efficiency by limiting re-emissions",level:"2"},{id:"sec_17",title:"5. Summary",level:"1"},{id:"sec_18",title:"List of abbreviations",level:"1"}],chapterReferences:[{id:"B1",body:'\nGlobal Mercury Assessment. UN Environment Programme. Geneva, Switzerland: Chemicals and Health Branch; 2018. ISBN: 978-92-807-3744-8\n'},{id:"B2",body:'\nWojnar K, Wisz J. Rtęć w polskiej energetyce. Energetyka. 2006;4:280-283 (in Polish)\n'},{id:"B3",body:'\nPavlish JH et al. Status review of mercury control options for coal-fired power plants. Fuel Processing Technology. 2003;82:89-165\n'},{id:"B4",body:'\nNiksa S, Fujiwara N. The impact of wet flue gas desulfurization scrubbing on mercury emissions from coal-fired power stations. Air & Waste Management Association. 2005;55:970-977\n'},{id:"B5",body:'\nGale T, Lani B, Offen G. Mechanisms governing the fate of mercury in coal-fired power systems. Fuel Processing Technology. 2008;89:139-151\n'},{id:"B6",body:'\nNguyen YV, Pessione GF. A three-year assessment of mercury mass balance from Lambton’s coal fired boilers equipped with FGD and SCR. In: Power Plant Air Pollution Control Symposium, Baltimore, August 28-31, 2008\n'},{id:"B7",body:'\nZhang L, Wang S, Wu Q , Wang F, Lin C, Zhang L, et al. Mercury transformation and speciation in flue gases from anthropogenic emission sources: A critical review. Atmospheric Chemistry and Physics. 2016;16:2417-2433\n'},{id:"B8",body:'\nEU Parliament Decision. Commission Implementing Decision (EU) 2017/1442 of 31 July 2017 Establishing Best Available Techniques (BAT) Conclusions, under Directive 2010/75/EU of the European Parliament and of the Council, for large combustion plants (notified under document C(2017) 5225)7\n'},{id:"B9",body:'\nAvailable from: http://www.hepaus.com/images/PDFs/hep_FPCS_MAPS_Desander_h.pdf\n\n'},{id:"B10",body:'\nGuidance on Best Available Techniques and Best Environmental Practices Coal-Fired Power Plants and Coal-Fired Industrial Boilers [Internet]. 2016. Available from: https://pdfs.semanticscholar.org\n\n'},{id:"B11",body:'\nVosteen B et al. Hg-Oxidation durch Chlor, Brom und Iod in Braunkohle-Kesseln. In: 51. Kraftwerkstechnisches Kolloquium—Annual Conference of the Energy Industry and Power Plant Industry, 22-23 October 2019. Dresden: International Congress Center; 2019\n'},{id:"B12",body:'\nOleniacz R. Oczyszczanie gazów odlotowych ze spalania odpadów niebezpiecznych. Inżynieria Środowiska. 2000;5(2):85-94 (in Polish)\n'},{id:"B13",body:'\nLindau L, Durham M, Bustard J, Cameron M. Mercury: Myths and realities. Modern Power Systems. 2003;3:30-32\n'},{id:"B14",body:'\nAvailable from: www.alstom.com/mercury-emissions-technology\n\n'},{id:"B15",body:'\nKrotla K. Wykorzystanie systemów katalitycznego oczyszczania spalin do redukcji emisji rtęci—Podstawy teoretyczne i przykłady z praktyki. In: VI Forum dyskusyjne ENERGOPOMIAR, Tatrzańska Łomnica, 16-19 kwietnia. 2013 (in Polish)\n'},{id:"B16",body:'\nNakamoto T, Kato Y, Nagai Y, Neidig K. SCR Catalyst, A Low Cost Technology for Mercury Mitigation, Hitachi Paper_Neidig_100213, Library: Mitsubishi Hitachi, Technical Papers\n'},{id:"B17",body:'\nJak W. EPA, No. ICR: Information Collection Request for Electric Utility Steam Generating Unit Hg Emissions, Information Collection Effort. 1858; 1999\n'},{id:"B18",body:'\nKrzyżyńska R, Hutson ND. Effect of solution pH on SO2, NOx, and Hg removal from simulated coal combustion flue gas in an oxidant-enhanced wet scrubber. Journal of the Air & Waste Management Association. 2012;62:212-220\n'},{id:"B19",body:'\nWilcox J et al. Mercury adsorption and oxidation in coal combustion and gasification processes. International Journal of Coal Geology. 2012;90-91:4-20\n'},{id:"B20",body:'\nHower JC et al. Mercury capture by native fly ash carbons in coal-fired power plants. Progress in Energy and Combustion Science. 2010;36:510-529\n'},{id:"B21",body:'\nWilcox J. A kinetic investigation of high-temperature mercury oxidation by chlorine. The Journal of Physical Chemistry. 2009;113(24):6633-6639\n'},{id:"B22",body:'\nSenior CL, Johnson SA. Impact of carbon-in-ash on mercury removal across particulate control devices in coal-fired power plants. Energy & Fuels. 2005;19:859-863\n'},{id:"B23",body:'\nCauch B, Silcox GD, Lighty JAS, JOL W, Fry A, Senior CL. Confounding effects of aqueous-phase impinger chemistry on apparent oxidation of mercury in flue gases. Environmental Science & Technology. 2008;42(7):2594-2599\n'},{id:"B24",body:'\nGostomczyk MA, Jędrusik M. Doświadczalna instalacja do redukcji emisji SO2, NOx i rtęci ze spalin kotłowych. Archiwum Energetyki. 2008;38(2):97-104. (in Polish)\n'},{id:"B25",body:'\nJędrusik M, Świerczok A, Krzyżyńska R. Usuwanie rtęci w elektrofiltrach. Przemysl Chemiczny. 2014;93(11):1885-1888 (in Polish)\n'},{id:"B26",body:'\nLee SJ et al. Speciation and mass distribution of mercury in a bituminous coal-fired power plant. Atmospheric Environment. 2006;40:2215-2224\n'},{id:"B27",body:'\nZhang L et al. Mercury emission from six coal-fired power plants in China. Fuel Processing Technology. 2008;89:1033-1040\n'},{id:"B28",body:'\nUS 2002/0068030A1. Method for Controlling Elemental Mercury Emission. Patent US 2002/0068030A1, June 6, 2002\n'},{id:"B29",body:'\nKnura P. Półsucha metoda odsiarczania spalin z zastosowaniem reaktora pneumatycznego zintegrowanego z filtrem tkaninowym (metoda RP + FT)—Kierunki rozwoju technologii, potencjał i możliwości. In: VI Forum dyskusyjne ENERGOPOMIAR, Tatrzańska Łomnica, 16-19 kwietnia 2013 (in Polish)\n'},{id:"B30",body:'\nCarpenter AM. Advances in Multi-Pollutant Control. IEA Clean Coal Centre; 2013. Available from: https://www.usea.org/sites/default/files/112013_Advances%20in%20multi-pollutant%20control_ccc227.pdf\n\n'},{id:"B31",body:'\nOzonek J. Analiza procesów wytwarzania ozonu dla potrzeb ochrony środowiska. Lublin: Państwowa Akademia Nauk; 2003 (in Polish)\n'},{id:"B32",body:'\nUdasin S. Firm to test out technology for purifying emissions. The Jerusalem Post. 2012. Available from: www.jpost.com/Sci-Tech/Article.aspx?id=269347\n\n'},{id:"B33",body:'\nLextran. Lextran Retrofit/Upgrade Solution: Effectively Controlling the Emissions and the Expenses. Israel: Lextran; 2012. Available from: www.lextran.co.il/objects/Retrofit-upgrade20-9-12.pdf\n\n'},{id:"B34",body:'\nOmar K. Evaluation of BOC’s Lotox process for the oxidation of elemental mercury in flue gas from a coal-fired boiler. United States; 2008. DOI: 10.2172/993830\n'},{id:"B35",body:'\nJarvis JB, Day AT, Suchak NJ. LoTOx™ process flexibility and multi-pollutant control capability. In: Combined Power Plant Air Pollutant Control Mega Symposium, Washington, DC, USA, 19-22 May 2003. Pittsburgh, PA, USA, Air and Waste Management Association, Paper 147. 2003\n'},{id:"B36",body:'\nA pioneering NOx removal technology for the power industry. Modern Power Systems. 2015;35(5):32-33\n'},{id:"B37",body:'\nCrapsey K. Eco Power Solutions Multi-Pollutant Emissions Control Systems. Northfield, IL, USA: The Mcllvaine Company; 2012. Available from: www.mcilvainecompany.com/Universal_Power/Subscriber/PowerDescriptionLinks/Kevin%20Craspey%20-%20Eco%20Power%20Solutions%208-17-12.pdf\n\n'},{id:"B38",body:'\nLiu YX, Wang Q , Yin YS, Pan JF, Zhang J. Advanced oxidation removal of NO and SO2 from flue gas by using ultraviolet/H2O2/NaOH process. Chemical Engineering Research and Design. 2014;92:1907-1914\n'},{id:"B39",body:'\nHuang XM, Ding J, Zhong Q. Catalytic decomposition of H2O2 over Fe-based catalysts for simultaneous removal of NOx and SO2. Applied Surface Science. 2015;326:66-72\n'},{id:"B40",body:'\nDing J, Zhong Q , Zhang S. Catalytic efficiency of iron oxides in decomposition of H2O2 for simultaneous NOx and SO2 removal: Effect of calcination temperature. Journal of Molecular Catalysis A: Chemical. 2014;393:222-231\n'},{id:"B41",body:'\nZhao Y, Hao RL, Guo Q , Feng YN. Simultaneous removal of SO2 and NO by a vaporized enhanced-Fenton reagent. Fuel Processing Technology. 2015;137:8-15\n'},{id:"B42",body:'\nHao R, Zhao Y, Yuan B, Zhou S, Yang S. Establishment of a novel advanced oxidation process for economical and effective removal of SO2 and NO. Journal of Hazardous Materials. 2016;318:224-232\n'},{id:"B43",body:'\nKrzyżynska R, Hutson ND. The importance of the location of sodium chlorite application in a multi pollutant flue gas cleaning system. Journal of the Air and Waste Management Association. 2012;62(6):707-716\n'},{id:"B44",body:'\nJędrusik M, Gostomczyk MA, Świerczok A, Łuszkiewicz D, Kobylańska M, et al. Fuel. 2019;238:507-531. DOI: 10.1016/j.fuel.2018.10.131\n'},{id:"B45",body:'\nPolish Standard PN93/Z-04009/06. Air Purity Protection. Examination of the Content of Nitrogen and Its Compounds. 1993 (in Polish)\n'},{id:"B46",body:'\nLee HK, Deshwal BR, Yoo KS. Simultaneous removal of SO2 and NO by sodium chlorite solution in wetted-wall column. Korean Journal of Chemical Engineering. 2005;22:208-213. DOI: 10.1007/BF02701486\n'},{id:"B47",body:'\nSun Y, Hong X, Zhu T, Guo X, Xie D. The chemical behaviors of nitrogen dioxide absorption in sulfite solution. Applied Sciences. 2017;7(4):377. DOI: 10.3390/app7040377\n'},{id:"B48",body:'\nHao R, Wang X, Liang Y, Lu Y, Cai Y, Mao X, et al. Reactivity of NaClO2 and HA-Na in air pollutants removal: Active species identification and cooperative effect revelation. Chemical Engineering Journal. 2017;330:1279-1288. DOI: 10.1016/j.cej.2017.08.085\n'},{id:"B49",body:'\nOchoa-Gonzales R et al. Control of Hg0 re-emission from gypsum slurries by means of additives in typical wet scrubber conditions. Fuel. 2013;105:112-118\n'},{id:"B50",body:'\nHeidel B, Hilber M, Scheffknecht G. Impact of additives for enhanced sulfur dioxide removal on re-emissions of mercury in wet flue gas desulfurization. Applied Energy. 2014;114:485-491\n'},{id:"B51",body:'\nKeiser B, et al. Improving Capture of Mercury Efficiency of WFGDs by Reducing Mercury Re-Emission. US8110163B2. 2012\n'},{id:"B52",body:'\nWo J et al. Hg2+ reduction and re-emission from simulated wet flue gas desulfurization liquors. Journal of Hazardous Materials. 2009;165(2-3):1106-1110\n'},{id:"B53",body:'\nOmine N et al. Study of elemental mercury re-emission in simulated wet scrubber. Fuel. 2012;91:93-101\n'},{id:"B54",body:'\nWang Y, Liu Y, et al. Experimental study on the absorption behaviors of gas phase bivalent mercury in Ca-based wet flue gas desulfurization slurry system. Journal of Hazardous Materials. 2010;183:902-907\n'},{id:"B55",body:'\nTang T, Xu J, Lu R, Wo J, Xu X. Enhanced Hg2+ removal and Hg0 re-emission control from wet flue gas desulfurization liquors with additives. Fuel. 2010;89(12):3613-3617\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Maria Jędrusik",address:"maria.jedrusik@pwr.edu.pl",affiliation:'
Faculty of Mechanical and Power Engineering, Wrocław University of Science and Technology, Wrocław, Poland
Faculty of Mechanical and Power Engineering, Wrocław University of Science and Technology, Wrocław, Poland
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In this study, nonedible crude Mahua oil has been used to extract biodiesel. Performance, emission and combustion characteristics of Mahua oil biodiesel blends with conventional diesel are compared on a single cylinder, natural aspirated, water-cooled direct injection (DI) diesel engine. Brake thermal efficiency of an engine fuelled with Mahua biodiesel blend B30 has been shown nearly same or insignificant lower compare to mineral diesel. The optimum engine operating condition based on lower brake specific fuel consumption and higher brake thermal efficiency was observed at 60% load for blend B30 of crude Mahua oil biodiesel. From an emissions point of view blend, B30 was found to be the best fuel as it showed lesser exhaust emission such as CO, HC, CO2, and NOx. Heat and pressure curve with respect to crank angle showed the details of combustion characteristics and revealed that combustion starts earlier for higher biodiesel blends. Results show that biodiesel obtained from nonedible Mahua oil gave better results and can be used as an excellent substitute for fossil fuels.",signatures:"Aman Hira, Debasish Das and Ranjna Thakur",authors:[{id:"277428",title:"Mr.",name:"Aman",surname:"Hira",fullName:"Aman Hira",slug:"aman-hira",email:"amanhira55@yahoo.com"},{id:"286519",title:"Dr.",name:"Debasish",surname:"Das",fullName:"Debasish Das",slug:"debasish-das",email:"debasish@nith.com"},{id:"286528",title:"Mrs.",name:"Ranjna",surname:"Thakur",fullName:"Ranjna Thakur",slug:"ranjna-thakur",email:"ranjnathakur23may@gmail.com"}],book:{title:"Introduction to Diesel Emissions",slug:"introduction-to-diesel-emissions",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"252214",title:"Dr.",name:"Nehemiah Sabinus",surname:"Alozie",slug:"nehemiah-sabinus-alozie",fullName:"Nehemiah Sabinus Alozie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"277430",title:"Dr.",name:"Melvin Victor",surname:"Depoures",slug:"melvin-victor-depoures",fullName:"Melvin Victor Depoures",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"277431",title:"Dr.",name:"Damodharan",surname:"Dillikannan",slug:"damodharan-dillikannan",fullName:"Damodharan Dillikannan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"277432",title:"Dr.",name:"Gopal",surname:"Kaliyaperumal",slug:"gopal-kaliyaperumal",fullName:"Gopal Kaliyaperumal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"280734",title:"Mr.",name:"Ramakrishna",surname:"Morla",slug:"ramakrishna-morla",fullName:"Ramakrishna Morla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"280738",title:"Prof.",name:"Shivakumar",surname:"Karekal",slug:"shivakumar-karekal",fullName:"Shivakumar Karekal",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"280739",title:"Dr.",name:"Ajit",surname:"Godbole",slug:"ajit-godbole",fullName:"Ajit Godbole",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"284200",title:"Prof.",name:"Lionel Christopher",surname:"Ganippa",slug:"lionel-christopher-ganippa",fullName:"Lionel Christopher Ganippa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"286519",title:"Dr.",name:"Debasish",surname:"Das",slug:"debasish-das",fullName:"Debasish Das",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"286528",title:"Mrs.",name:"Ranjna",surname:"Thakur",slug:"ranjna-thakur",fullName:"Ranjna Thakur",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"WIS-cost",title:"What Does It Cost?",intro:"
Open Access publishing helps remove barriers and allows everyone to access valuable information, but article and book processing charges also exclude talented authors and editors who can’t afford to pay. The goal of our Women in Science program is to charge zero APCs, so none of our authors or editors have to pay for publication.
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I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/55578/images/4574_n.png",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. 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