Muralidhar L. Hegde

Houston Methodist Research Institute

Dr. Hegde is Associate Professor at Houston Methodist Research Institute (HMRI), Houston, Texas, USA. He also holds adjunct faculty appointments at Weill Medical College of Cornell University and Texas A&M University. Dr. Hegde directs a research program focused on delineating the molecular insights into the involvement of genome damage/repair responses in human brain pathologies and developing novel mechanism-based treatment strategies for these diseases. Amyotrophic Lateral Sclerosis is a major focus of Dr. Hegde’s research program, with recent publications in prestigious journals that include Nature Communications, PNAS and JBC on this topic. Dr. Hegde’s research has been continuously funded by multiple grants from the National Institutes of Health and other foundations. He serves on the editorial boards of half a dozen journals.

1books edited

1chapters authored

Latest work with IntechOpen by Muralidhar L. Hegde

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.

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