Syed Ali Raza Naqvi

By Syed Ali Raza Naqvi, Sana Nadeem, Sana Komal, Syed Ali Asad Naqvi, Muhammad Samee Mubarik, Sajid Yaqub Qureshi, Shahzad Ahmad, Ali Abbas, Muhammad Zahid, Naeem-Ul-Haq Khan, Syed Shujat Raza and Nosheen Aslam

The aim of this current piece of writing is to draw the attention of readers and researchers toward the natural antioxidants that can take the place of synthetic antibiotics to avoid bacterial resistance and gastrotoxicity/nephrotoxicity. Antioxidants such as polyphenols, vitamins, and carotenoids are the organic compounds mainly extracted from natural sources and dominantly involved in boosting the defense system of organisms. The main public health-related issue over the globe is ever-growing bacterial resistance to synthetic antibiotics, which is being continuously reported during the last decade. Further, the pipeline of the development of new synthetic antibacterial agents to replace the resistant antibiotics in clinical set-up is gradually drying up. This scenario originated the concept to revive the interest toward natural antibacterial products due to their chemical diversity, which provide important therapeutic effect and make the microbes unable to copy them for creating resistance. Natural products, especially polyphenols had been seen in antioxidant, antibacterial, anticancer, anti-inflammation, and antiviral activities with encouraging results. In this chapter, we will focus over the role of natural antioxidants as antibacterial agents.

Part of the book: Antioxidants

By Syed Ali Raza Naqvi and Muhammad Babar Imran

Nuclear medicine techniques have a great deal of advantage of using gamma radiation emitter radiolabeled compounds to diagnose the long list of infectious and malignant disorders in human systems. The gamma emitter radionuclide-labeled compounds are associated with single photon emission computed tomography (SPECT) camera. SPECT camera mainly offers the detection and analysis of gamma rays origin to furnish the imaging of defective organs in the body. There are about 85% radiopharmaceuticals in clinical practice which are being detected by SPECT camera. The following chapter is an update about the SPECT radiopharmaceuticals that were developed and tried for infection and cancer diagnosis.

Part of the book: Medical Isotopes

By Sana Komal, Sana Nadeem, Zahra Faheem, Arouma Raza, Komal Sarwer, Hijab Umer, Samina Roohi and Syed Ali Raza Naqvi

Scintigraphic techniques have opened a new era of developments in the localization of infectious and cancerous foci. Diseases area targeting mechanisms of radiopharmaceuticals encompasses visualization, characterization, and measurement of physiological and biological functioning at targeted sites in addition to measure the area and density of the disease. The accumulation of a radiopharmaceutical at specific organ is based upon numerous processes such as enzymatic interactions, receptor binding site, transport of chemical species and elimination of damaged cells from circulation by a normal metabolic process. PET and SPECT are developing scanning techniques that provides effective diagnostic tool to identify pathophysiology of diseased cells. In this chapter, we are exploring and explaining different mechanisms of radiopharmaceutical localization for imaging and therapeutic processes. The knowledge of these mechanisms will help to develop target based new radiopharmaceuticals using variety of medically used radioisotopes either for imaging or therapy of diseased cells.

Part of the book: Medical Isotopes