One of the most important breakthroughs in the understanding of biological features of bones is the explanation of the role of cytokine in reshaping of the bone (remodeling) including the alveolar tooth bone exposed to the effect of the mechanical force during the orthodontic treatment. Since remodeling of the bone initiated by orthodontic forces is connected during its early stage with the inflammation of the surrounding tissue, the assumption was presented about the role of the pro-inflammation cytokine in the process of remodeling of the bone, primarily IL-1β, IL-б, and TNF. These cytokines are mediators in the reactions of the acute stage of inflammation, as well as in the processes of metabolism, stimulation of resorption, and inhibition of bone creation. In this chapter, we aimed to review the existing knowledge about the roles and dynamics of the change in these three cytokines simultaneously during the early stage of the orthodontic tooth movement.
Part of the book: Current Approaches in Orthodontics