The aim of our work is to use a new modality for visualization of intraocular tumors in three-dimensional space for planning of stereotactic radiosurgery procedure on linear accelerator. Malignant uveal melanoma is the most common malignant tumor of the inner eye structures in adults. Stereotactic radiosurgery on linear accelerator is the method of treatment that requires precise planning. However, in some cases, it is very difficult to imagine the structures based only on fusion of two-dimensional computed tomography (CT) and magnetic resonance imaging (MRI) scans. For the team of specialists planning the procedure, 3D printed models represent the way how to perceive the real shape of the tumor and its location considering the important structures of the eye globe. By using the open-source software for segmentation (3D Slicer), we created a virtual 3D model of the eye globe with a tumor that utilized tissue density information based on CT and/or MRI dataset. By creating and introducing a new imaging modality for tumor visualization, we provided real 3D model of the eye globe for the specialists that enabled them more effective planning of the stereotactic radiosurgery.
Part of the book: 3D Printing
Advances in retinoblastoma treatment in children nowadays and in the last decades lead to success and adulthood life without problems. Treatment modalities used in childhood to cure the retinoblastoma can affect health later. Some secondary malignancies in patients with retinoblastoma may be long-term side effects of radiation and chemotherapy. However, rates of second cancers in people treated for hereditary retinoblastoma are higher than in people who had sporadic retinoblastoma. The survivors of retinoblastoma in whom second malignant neoplasms develop are at a higher risk for the development of additional tumors than they were for the development of a second tumor. The standardized incidence rate of secondary malignancies is about 15% in inherited cases and about 1.5% in nonheritable retinoblastoma. However, today there is no clear consensus on what, if any, screening protocol would be most appropriate and effective.
Part of the book: Retinoblastoma
Currently, melanoma of uvea is the most well-known essential tumor, which is intaocular and malignant. Treatment using radiation has now supplanted enucleation as the therapy of decision. Radioactive eye plaques and treatment using proton are being the two most examined radiotherapeutic modalities. All the more as of late, stereotactic radiosurgery and fractionated stereotactic radiotherapy have risen as promising, non-intrusive medicines for uveal melanoma. Technique called stereotactic radiosurgery might be viewed as like “not surgery” on the grounds no extractions are included. All things being equal, it is a serious strategy for radiation treatment that conveys high dosages of radiation to exceptionally little territories and volumes.
Part of the book: Melanoma