Name : Dr.Anshul Sawhney Permanent Address : S/o Mr. Raj Kumar Sawhney J-11/13 Rajouri Garden New Delhi-110027 Contact no. : Mob: 7351413026,9868145914 Email : dranshul1986@yahoo.co.in Designation : Senior Resident Work Experience ∑ 2 years 7 months Post graduate teaching experience in Uttar Pradesh University Of Medical Sciences ( Govt College Saifai) ∑ Currently working as a Senior Resident in Department of Periodontology, UPUMS Saifai
The use of chemotherapeutic agents or drugs specifically designed to treat periodontal diseases is emerging to aid in this risk assessment and reduction strategy. They include locally applied and systemically delivered antimicrobials and host modulatory therapies. Tetracyclines are a group of antibiotics produced naturally from certain species of Streptomyces or derived semisynthetically. Their advantages were broad-spectrum activity, better tolerated, and less toxic to some individuals. Further modifications of these natural products by means of synthetic reactions and reagents led to the production of the clinically used antibiotic tetracycline compounds—minocycline, doxycycline, and methacycline. Tetracyclines are now recognized to have non-antimicrobial properties that may also be therapeutically advantageous. They have anti-inflammatory properties, particularly in the treatment of certain skin diseases. One important aspect is their ability to inhibit host collagenolytic enzymes, an effect that inhibits the connective tissue degradation and thus preventing bone resorption. To identify the site of the anticollagenase property, Golub and co-workers in 1991 synthesized 10 different analogs of tetracyclines known as chemically modified tetracyclines (CMTs 1-10). All 10 analogs lacked antimicrobial efficacy and inhibited collagenase activity, but only 1 did not. Though not approved for human use by the FDA, preliminary studies using CMT-3 are being investigated on humans with cancer.
Part of the book: Periodontology and Dental Implantology