Coordinates of characteristic points of the generalized steel deformation diagram, constructed in the axes
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",isbn:"978-1-80355-403-7",printIsbn:"978-1-80355-402-0",pdfIsbn:"978-1-80355-404-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"360fe5dabd12a1f91a5658a5fe3eff66",bookSignature:"Associate Prof. Murat Eyvaz and Dr. Ahmed Albahnasawi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11934.jpg",keywords:"Hydrogen Sources, Hydrogen Production, Hydrogen Safety, Hydrogen Storage Methods, Environmental Impacts of Hydrogen, Synthetic Fertilizer Production, Aromatization, Hydrocracking, Hydrodesulfurization, Fuel Cells, Gas Turbines, Hydrogen Driven Vehicles",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 18th 2022",dateEndSecondStepPublish:"March 18th 2022",dateEndThirdStepPublish:"May 17th 2022",dateEndFourthStepPublish:"August 5th 2022",dateEndFifthStepPublish:"October 4th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Eyvaz is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers and has four patents on wastewater treatment systems.",coeditorOneBiosketch:"Dr. Albahnasawi is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers on water and wastewater treatment and waste remediation.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"170083",title:"Associate Prof.",name:"Murat",middleName:null,surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz",profilePictureURL:"https://mts.intechopen.com/storage/users/170083/images/system/170083.png",biography:"Dr. Murat Eyvaz is an associate professor in the Environmental Engineering Department, Gebze Technical University, Turkey. His research interests include applications in water and wastewater treatment facilities, electrochemical treatment processes, filtration systems at the lab and pilot-scale, membrane processes (forward osmosis, reverse osmosis, membrane bioreactors), membrane manufacturing methods (polymeric membranes, nanofiber membranes, electrospinning), spectrophotometric analyses (UV, atomic absorption spectrophotometry), chromatographic analyses (gas chromatography, high-pressure liquid chromatography). He has co-authored many journal articles and conference papers and has taken part in many national projects. He serves as an editor and reviewer for many indexed journals. 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Based on his Ph.D. research, Dr. Albahnasawi published three journal articles and participated in three international conferences. 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Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"68521",title:"The Risk of Chromosomal Abnormalities in Cases of Minor and Major Fetal Anomalies in the Second Trimester",doi:"10.5772/intechopen.88271",slug:"the-risk-of-chromosomal-abnormalities-in-cases-of-minor-and-major-fetal-anomalies-in-the-second-trim",body:'The chromosomal abnormalities account for a considerable part of the anomalies of the intrauterine fetus. Chromosomal abnormalities are the numerical (aneuploidies) and structural anomalies, which can be demonstrated by special methods of examination. The numerical and structural anomalies can be duplications/trisomies, deletions/monosomies, and other rearrangements on the chromosomes.
The autosomal trisomies and unbalanced rearrangements might cause severe multiple malformation syndromes and mental retardation. The rate of the intrauterine deaths is high. They cause mainly severe diseases; in some cases they are associated with anomalies which are incompatible with the postnatal life.
Besides the age, a history of aneuploidy, and noninvasive tests, positive ultrasound findings—which could be major structural abnormalities or minor ultrasound markers—can be an indicator for chromosome analysis [1].
As the first-trimester nuchal edemas (nuchal translucency, NT), the second-trimester nuchal edemas (nuchal thickening, nuchal fold, NF) also elevate the risk of chromosome abnormalities. It is important to distinguish nuchal edema and cystic hygroma (CH), and in the case of nonimmune hydrops (NH), it is also important to discuss cases with or without cystic hygroma separately.
Abnormalities with subcutaneous edema (nonimmune hydrops (NH), cystic hygroma, nuchal edema) increase the risk of chromosome abnormalities. They may warn of a possible intrauterine infection; in the case of nonimmune hydrops, for example, parvovirus B19 infection may occur. They may also be indicative of other pathologies accompanied with fetal anemia, including thalassemia, twin-to-twin transfusion, and disorders of fetal circulation and abnormal anatomy of the fetal heart.
In the second trimester, we examine the thickened nuchal fold (nuchal thickening, NF) in the horizontal section, level with the cerebellum and also containing the cavum septum pellucidum and the cisterna magna. This method, in contrast to the one used in the first trimester, measures the thickness of the soft tissue from the external aspect of the skin to the external aspect of the bone. Authors suggest 5 mm as a cutoff value [2, 3]. A large nuchal translucency detected in the first trimester is a non-specific malformation, and in most cases it resolves during the second trimester of the pregnancy, although it might persist in certain cases to show a picture of nuchal thickening. It indicates an increased risk of trisomy 21 (Down syndrome) [4].
Benacerraf et al. were the first in drawing the attention to the fact that the nuchal fold or nuchal thickening (≥6 mm) observed during the ultrasound examination in the second trimester increases the risk of Down syndrome [4].
Numerous authors carried out similar examinations, subsequently demonstrating different results. Gray and Crane [3] tried to determine the proper cutoff values of nuchal thickening. They formulated two groups according to the size of the pregnancy, putting the values measured in weeks 14–18 to the first group and the data of weeks 19–24 to the second group. Considering the examinations, the suggested cutoff value in the first group (weeks 14–18) is ≥5 mm, and in the second group (weeks 19–24), it is ≥6 mm [5]. In their investigations, Gray and Crane [3] detected pathological karyotypes in 12 out of 47 cases (25.53%). Analyzing 23 cases, DeVore and Alfi found pathological karyotypes in 9 cases (39.13%) [6].
Other authors detected pathological karyotypes in 10% of second-trimester nuchal edema. Grandjean and Sarramon [7] processed the data of 3308 ultrasound examinations, with the help of 12 centers, and they found nuchal thickening in 38% of the cases of trisomy 21. According to the records of 12 centers, they performed karyotyping of 295 pregnancies in the second trimester with nuchal thickening. They found abnormal chromosomes in 22 cases (7.46%), 17 of these were trisomy 21 (5.76%) [7]. Gonen et al. [8] carried out karyotyping in 573 cases because of positive ultrasound findings during ultrasound examinations in the second trimester. There were 38 chromosome analyses carried out due to nuchal thickenings; in one case they found an abnormal karyotype (2.63%) [8]. Zimmer et al. discussed their cases of early second-trimester nuchal edema in 43 out of 1254 cases (3.43%); they detected pathological karyotypes, trisomy 21 being the chief cause in 27 cases, while other pathological karyotypes were blamed in 16 cases [9].
Beke et al. [10] showed a value within 10% in the case of nuchal fold (thickening) measured in the second trimester. A total of 254 cases of chromosomal examination was performed for second-trimester nuchal edema, and in 14 cases, an abnormal karyotype was detected (5.51%). With the highest frequency, monosomy X occurred (nine cases, 3.54%), while in three cases trisomy 21, in 1-1 cases trisomy 18 (Edwards syndrome), and another chromosome abnormality were detected [10].
Cystic hygroma is observable in the first and second trimesters. It can be differentiated from nuchal translucency and nuchal thickening by the clearly isolated fluid space and the typical medial line septation shown on ultrasound examination [11, 12]. Cystic hygroma often persists and is often associated with aneuploidy (mainly monosomy X), other abnormalities, and fetal loss [12].
In the case of cystic hygroma, the risk of the chromosome abnormality is even higher than in cases of nuchal thickening. Bronshtein et al. found chromosome anomalies in 6 of 106 nonseptated cases (5.66%), whereas the risk of the chromosome abnormality in the 25 septated cases was 72% [12].
Nadel et al. [13] examined in separate groups those cases where the cystic hygroma occurred by itself (isolated) and those where it was a part of the hydrops phenomenon. In cases of individually occurring 26 hygromas, there were chromosome abnormalities in 12 cases (46.15%), while in hydrops-associated cases (37 cases), they found 31 chromosome anomalies (83.78%) [13]. Due to cystic hygroma, Gonen et al. detected 15 cases of pathological (abnormal) karyotype in 182 cases (8.24%) [8]. Sohn and Gast [14] found 20 cases of abnormal karyotype of the 57 cystic hygroma cases (35.09%). There were 11 cases of monosomy X (Turner syndrome), 5 cases of trisomy 21, and 4 cases of trisomy 18 [14]. Taipale et al. carried out karyotyping in 76 cases of cystic hygroma, and they found chromosome abnormalities in 18 cases (23.68%), monosomy X in 5 cases, trisomy 21 in 7 cases, and trisomy 13 (Patau syndrome) and trisomy 18 in 6 cases [15].
Beke et al. [10] had a similar result. In terms of isolated cystic hygroma, fetal chromosome examinations were performed in 27 cases, and in 13 cases abnormal karyotypes were detected (48.15%). When cystic hygroma was associated with hydrops, a total of 13 cases was investigated, and 7 cases of chromosomal abnormalities (53.85%) were detected [10].
In the first and early second trimesters, Rosati and Guariglia [16] examined the volume of cystic hygromas by volumetric calculations. They also analyzed the proportion of associated chromosomal abnormalities, and in 8 of 14 septated cases, they detected pathological karyotypes (57.14%), whereas four pathological karyotypes (21.05%) were seen in the 19 nonseptated cases. In summary, the 12 patients with chromosomal abnormalities (36.36%) were divided as follows: trisomy 21 in 6 patients, monosomy X in 4 cases, and trisomy 18 and 13 in 1 case each [16]. Examining the septated and nonseptated cases together, Tanriverdi et al. found 13 pathological karyotypes (56.52%) among the 23 karyotyped patients [17]. Donnenfeld et al. applied karyotyping and fluorescent in situ hybridization (FISH) in the chromosomal investigation of the cells in the sample obtained from the fluid of the cystic hygroma and could justify monosomy X in 86% [18].
Examining a total of 218 fetuses with subcutaneous edema, Gezer et al. [19] found that nuchal fold, cystic hygroma, and nonimmune hydrops could be significant markers for abnormal chromosome numbers. Of these 218 cases, 71 (32.57%) were diagnosed with abnormal karyotype. The percentage breakdown in 71 cases was as follows: 37% monosomy X, 44% trisomy 21, 15% trisomy 18, and 4% trisomy 13 [19].
Similarly to cystic hygroma, nonimmune hydrops can be observed both in the first and second trimesters and is often associated with aneuploidy (monosomy X or trisomy 21) and fetal loss [13].
Nicolaides et al. studied 37 cases in 1986 and demonstrated 12 cases of chromosome anomalies (32.43%) [20]. Gembruch et al. found 17 abnormal karyotypes examining 45 hydrops cases (37.78%), 10 cases of monosomy X (1 mosaic form), 6 cases of trisomy 21, and 1 case of trisomy 18 [21].
Boyd and Keeling [22] and Anandakumar et al. [23] found X-monosomies in 50% of the demonstrated chromosome abnormalities. Boyd and Keeling [22] found 11 X-monosomies of the 22 cases of chromosome anomalies of the 72 nonimmune hydrops cases (30.56%), while Anandakumar et al. [23] carried out karyotyping in cases of 100 hydrops-affected fetuses and demonstrated 5 cases of X-monosomies of 10 abnormal cases (10%).
Schwanitz et al. examined in separate groups the nonimmune hydrops cases associated with cystic hygroma and the individually occurring ones. When it was associated with cystic hygroma, abnormal karyotypes were demonstrated in 54.39%; without cystic hygroma this rate was 27.69% [24].
Has carried out investigations into nonimmune hydrops in the first trimester and found 9 pathological karyotypes (47.37%) out of 19 cases [25].
In the case of nonimmune hydrops, Beke et al. found chromosomal abnormalities in 4 out of 20 cases (20%), in each case monosomy X [10].
In the case of ventriculomegaly, a greater than normal amount of liquor expands the ventricular system. Cerebrospinal fluid may be overproduced, impaired, or obstructed. Increased pressure leads to thinning of the brain, creating hydrocephalus internus. Hydrocephalus externus is referred to as the proliferation of liquor in the subarachnoid space. Ultrasound first shows the expansion of the posterior horn of the side chamber. In cases of choroid plexus cyst and other cranial malformations, the risk of chromosomal abnormalities is also elevated.
In cases of cerebral anomalies, we define ventricular dilatation (ventriculomegaly) as a lateral ventricle with a diameter ≥ 10 mm. The ventricle of normal male fetuses is mildly wider (average 6.4 mm) than of the ventricle of normal female fetuses (average 5.8 mm) [26]. Ventriculomegaly increases the incidence rate of aneuploidy (trisomy 21 and other aneuploidies) [27, 28].
Several authors were examining ventriculomegaly as one possible marker of the fetal chromosome abnormalities in the second trimester. Nicolaides et al. carried out karyotyping in 9 cases because of fetal ventriculomegaly, examining this among other anomalies, and they found chromosome abnormalities in 2 cases (22.22%) [20]. Following this, Mahony et al. [28] found 1 case of 20 ventriculomegalies (5%); Bromley et al. [27] observed 5 cases of chromosome anomalies examining 44 cases of ventriculomegaly (11.36%). The study of Gonen et al. [8] also extended to more anomalies; as a part of it, they carried out karyotyping in 25 cases of ventriculomegalies and found no abnormal karyotypes. Terry et al. [29] detected abnormal chromosomes in 3 cases of the 25 examined fetuses (12%).
Beke et al. [30] found different karyotypes in 26 (6.25%) out of the 416 examined fetuses. If ventriculomegaly was isolated (191 cases), the rate of the chromosome abnormality was 3.7% (7 cases). In four cases, trisomy 21 was detected, in two cases monosomy X, and in one case trisomy 18. Lateral ventricular dilation (ventriculomegaly) was associated with other ultrasound findings in 225 cases, and in 19 of these, there were chromosome abnormalities detected (8.4%). The distribution of pathological (abnormal) karyotypes was as follows: 4-4 cases of monosomy X and 47, XXY karyotype (Klinefelter syndrome), 3-3 cases of trisomy 21 and trisomy 18, and 1-1 case of trisomy 13, 47,XXX, 47,XYY, 49,XXXY karyotypes and triploidy were detected. We found a higher rate in cases of bilateral anomaly (ventriculomegaly) (8.6%) than in unilateral cases (4.6%) [30].
According to the data of more authors, the choroid plexus cysts (CPC) mainly increase the risk for trisomy 18 [31, 32]. According to certain studies, the risk level does not depend on whether the anomaly is unilateral or bilateral, but other studies show that the larger the anomaly (>10 mm), the higher the risk [33, 34]. Certain authors suggest the 2–2.5 mm cutoff value [35], while others determined the 5 mm limiting value [33]. The cysts resolve practically every time, so the absence of the anomaly on a repeated ultrasound examination does not indicate a decrease in the risk [36].
Chudleigh et al. were the first who described cysts in the fetal choroid plexus [37]. Nicolaides et al. were the first who drew attention to the connection between the positive ultrasound finding of choroid plexus cysts and chromosome abnormalities, through a study including a small number of cases [20]. Thereafter, more authors demonstrated that fetal choroid plexus cysts mainly increase the risk of trisomy 18 and, to a lesser degree, the risk of trisomy 21.
Achiron et al. demonstrated 2 trisomy 18 cases from chromosome analysis of 30 CPC cases (6.67%); in 1 case the CPC was associated with other ultrasound anomalies [38]. Platt et al. found 4 cases of chromosome abnormalities from 62 cases (6.45%), in 3 cases it was trisomy 18, and in 1 case it was trisomy 21 [39]. Nadel et al. demonstrated 12 cases (5.13%) of abnormal chromosomes from a larger number of cases (234 cases), 11 of which were trisomy 18 (4.7%) and 1 case of triploidy, but from 234 cases there were 220 cases of isolated CPC, and in these cases they did not detect any chromosome abnormalities [40].
Walkinshaw et al. demonstrated 4 cases (2.63%) of chromosome anomalies out of 152 isolated CPC cases, 3 cases trisomy 18 (1.97%) and 1 case trisomy 21 [33]. Nava et al. found eight chromosome abnormalities in 176 cases (4.55%), 4 cases of trisomy 18 (2.27%), 2 cases of trisomy 21 (1.14%), 1 case of 47, XXY karyotype, and 1 case of another chromosome anomaly [41]. From the trisomy 18 cases, there was one case of isolated choroid plexus cyst, while in three cases the abnormality was associated with other ultrasound findings. Gonen et al. in 1995 demonstrated no abnormalities in the course of intrauterine karyotyping of 108 CPC cases [8].
Gray et al. performed karyotyping in 208 cases, and they detected abnormal karyotypes in 7 cases; each case was trisomy 18 (3.37%) [34]. Bakos et al. found 3 abnormal karyotypes out of 108 examined cases (2.78), 1 case was trisomy 18, and 1 case was trisomy 13 and one inversion of chromosome 9 [42].
Chitty et al. [43] with a larger number of cases found chromosome abnormalities in 14 cases (2.13%). They examined separately the isolated cases and the cases associated with other ultrasound anomalies. In 603 cases, the choroid plexus cyst was not associated with other ultrasound abnormalities, and in 3 cases (0.5%), they found abnormal karyotypes (each was trisomy 18); in 55 cases the abnormality was associated with other ultrasound findings, and in 11 cases (20%), they detected abnormal karyotypes (in 9 cases trisomy 18, in one case trisomy 21, and in 1 case 47,XXX karyotype) [43]. With a similarly large number of cases, Ghidini et al. examined the incidence of chromosome abnormalities in cases of choroid plexus cysts, they only examined the isolated cases (765 cases), and they found abnormal karyotypes (trisomy 18) in 13 cases (1.7%) [44].
Coco et al. [45] in 2004 examined separately the isolated cases and those associated with other abnormalities, the cases associated with minor and major ultrasound anomalies. The rate of abnormal karyotypes was 0.55% in total. In isolated cases (311 cases) and in associated cases with minor anomalies (43 cases), they did not find any abnormal karyotypes. In the two detected cases of trisomy 18, the choroid plexus cyst was associated with major anomalies (16.67% from 12 cases) [45]. Sahinoglu et al. [46] performed karyotyping in 109 cases due to choroid plexus cyst, 3.67% of the patients had an abnormal karyotype, in 102 cases, it was isolated anomaly, and in 3 cases they found chromosome abnormalities (2.94%). In seven cases, the choroid plexus cysts were associated with other ultrasound anomalies, and they found chromosome abnormality in one case (14.29%); in all the detected four cases, the abnormal karyotype was trisomy 18.
According to a 2008 study, of the 435 cases identified by CPC, 390 undertook karyotyping. Of these, anomalies were found in 14 fetuses (3.59%), with the highest frequency being trisomy 18 (6 cases, 1.54%); in 1 case trisomy 21 (1, 0.26%) and 1 case trisomy 9 (0.26%) were detected. The incidence of monosomy X was 0.77% (3 cases). In one case, 47, XXY karyotype (0.26%) and in two cases other chromosomal abnormalities (0.51%) were confirmed (46,XX/46,XY and 46,XY/47,XXY/47,XYY mosaicism). Of the cases studied, other ultrasound abnormalities associated with the plexus cyst were found in 178 pregnancies, and 7 abnormal karyotypes were found (3.93%), 5 cases of trisomy 18, and 2 cases of monosomy X. Choroid plexus cyst occurred as an isolated anomaly in 212 pregnancies (it was not associated with any other fetal ultrasound findings (anomalies) and/or poly/oligohydramnios), and 7 chromosome abnormalities (3.3%) were found, one of which was trisomy 18, 1 case trisomy 21, 1 case trisomy 9, 1 case monosomy X, and 1 case 47,XXY karyotype. The incidence of chromosome abnormalities was also similar in the case of unilateral and bilateral CPC; chromosome abnormalities were detected in the case of unilateral (3.3%) and in the case of bilateral anomalies (3.9%) [47].
Other cranial and cerebral anomalies (holoprosencephaly, agenesis or dysgenesis of the corpus callosum, Dandy-Walker malformation, and cleft lip or palate) according to observations increase the risk of chromosome abnormalities, but they do not increase the risk of trisomy 21 [48]. A strawberry-shaped head mainly increases the risk of trisomy 18 [49].
Benacerraf et al. reported five cases already in 1984, where they found intrauterine cleft lip and palate and holoprosencephaly during the ultrasound examinations, and the chromosome analysis verified trisomy 13 in two cases (33.33%) [50].
Both Parant et al. [51] and later Tongsong et al. [52] reported 12 cases where they diagnosed intrauterine holoprosencephaly. The karyotyping in Parant et al. [51]’s study verified trisomy 13 in four cases (33.33%); in Tongsong et al. [52]’s study, there were three cases of trisomies found (25%); in two cases it was trisomy 13 (16.67%), and in one case it was trisomy 18 (8.33%). Bullen et al. reported in their study (2001) 68 cases of holoprosencephaly, they made karyotyping in 52 cases, where they found an abnormal karyotype in 38% (from 20 cases in 15 cases it was trisomy 13, in 2 cases trisomy 18, and in 3 cases other chromosome anomalies, from which in 2 cases they recognized the deletion of the long arm of chromosome 13) [53]. Studying the etiology of the holoprosencephaly, besides the maternal diabetes and trisomy 13, there are also monogenic types [54].
In cases of cleft lip and/or palate, Perrotin et al. [55] demonstrated in their study that in those cases they examined, there were no chromosome anomalies provided the abnormality was isolated (14 cases), and when they detected it together with other positive ultrasound findings, the incidence rate of the chromosome abnormalities was high. In 26 cases, there were 15 chromosome anomalies (57.69%), in 8 cases trisomy 13, and in 5 cases trisomy 18 [55].
Aletebi and Fung [56] studied the abnormalities of the fossa posterior region, including the enlarged cisterna magna, the Dandy-Walker malformation, and the fossa posterior cyst. They found chromosome abnormalities (trisomy 18) in 1 of 15 cases (6.67%) [56].
Similarly, Beke et al. found in their study that the frequency of chromosome abnormalities was similar to other cranial abnormalities; with 44 fetuses being examined, they detected chromosome abnormalities in 7 cases (15.91%) [30].
The aim of Nazer Herrera et al. [57] was to estimate the prevalence of holoprosencephaly in relation to births. It turned out that this disorder occurred with low frequency in Chile, but it was associated with a high proportion of trisomy 13: occurring in 10.91% of the cases examined (6 out of 55 cases) [57].
In another study, this anatomical disorder and chromosome abnormalities were associated with a high proportion. According to a study in Japan, five out of seven holoprosencephaly cases (71.43%) showed the following differences: two children with trisomy 18, two children with trisomy 13, and one with 45,X karyotype [58].
The use of fetal echocardiography may further increase the importance of second-trimester ultrasound examinations for screening for chromosomal anomalies. This is particularly true in those cases where screening tests were not available in the first trimester or the pregnancy was only recognized later.
In the fetal heart, the echogenic intracardiac focus is observable in 3–4% of normal pregnancies [59]; according to some studies, this rate might reach 10% in the Asian population [60]. Its incidence, by some authors, increases the risk of trisomy 21 [61, 62, 63, 64, 65] and, according to some studies, trisomy 13 [66]. According to some literature data, the risk is higher if the anomaly is observable in both ventricles [61].
Bromley et al. [61, 62] examined in their studies (reported in 1995 and 1998) the correlation between the chromosome anomalies and the echogenic intracardiac focus detected during the ultrasound examinations. In 1995 they studied 66 cases and found trisomy 21 in 4 cases (6.06%) [61]. Chromosome abnormalities were found in 14 cases (4.83%) with a higher number of cases (290). In 1998, they examined 290 pregnancies in two groups and detected chromosome abnormalities (mainly trisomy 21) in 6.4% (125 cases) in that group where the maternal age was ≥35 years, and in the age group under 35 years (165 cases), this rate was 3.64% [62]. Winter et al. demonstrated in their similar report 16 cases of trisomy 21 of the studied 163 cases (9.28%) [65].
In a 2005 publication, the echogenic papillary muscle showed abnormal karyotype only when it was associated with other anomalies (4.69%), not in isolated cases [30].
Many authors investigated the correlation among the chromosome abnormalities and the ventricular septal defect (VSD) and the atrioventricular septal defect (AVSD). In some cases, the authors managed the cases discovered in the second trimester or later in pregnancy (third trimester) and the cases diagnosed after birth as aggregated data. Hajdu et al. studied 21 cases of AVSD and found chromosome anomalies in 9 cases (42.86%); 7 of these were trisomy 21, 1 case trisomy 18, and 1 case trisomy 22 [67].
Tennstedt et al. [68] analyzed all those cases where the fetopathological examination verified cardiac malformation, and there were ultrasound examinations and karyotyping during the pregnancy (altogether 129 cases). A total of 36 fetuses had VSD, and 21 fetuses had AVSD. In cases of VSD, there were 15 fetuses (41.67%) with detected chromosome anomalies (8 cases of trisomy 21, 4 cases of trisomy 18, 1 case of trisomy 13, 2 cases of other abnormalities). If AVSD occurred, the incidence rate of the chromosome anomalies was 61.9% (from 13 cases, 9 trisomy 21 and 3 trisomy 18, and in 1 case other anomaly) [68]. Delisle et al. [69] studied the incidence of the chromosome abnormalities in cases of AVSD detected by ultrasound examinations during pregnancy, and from the 38 cases, they found 22 (57.89%) with chromosome anomalies (19 cases of trisomy 21, 1 case of trisomy 18, 1 case of trisomy 13, and 1 case of other positive finding). Paladini et al. [70] reported a study about the risk of chromosome abnormalities in cases of all cardiac (heart and large blood vessels) anomalies. In case of ventricular septal defect, the incidence rate of the chromosome anomalies was 45.33% (34 of 75 cases), and in case of atrioventricular septal defect, this rate was 80% (32 of 40 cases) [70]. From the 34 VSD cases, there were 14 cases of trisomy 21 (18.67%), 16 cases of trisomy 18 (21.33%), 2 cases of monosomy X (2.67%), and 2 other anomalies detectable. The distribution of the 32 abnormal karyotypes in case of AVSD was the following: 26 cases of trisomy 21 (65%), 3 cases of trisomy 18 (7.5%), and 3 other anomalies.
In their work, Beke et al. found abnormalities in 4 out of 18 fetuses with VSD (22.22%), including 2 cases of trisomy 18 (11.11%) and 1 case of trisomy 13 (5.56%) as well as 1 case of another anomaly [30].
Hajdu et al. [71] later, in 2005 in the case of AVSD, the frequency of the abnormal karyotypes was 66.67%. They studied 39 cases of AVSD and found chromosome anomalies in 19 cases (66.67%); 19 of these were trisomy 21, 6 cases trisomy 18, and 1 case trisomy 22 [71].
A 2006 study dealt with the VSD-related clinical characteristics of the Moroccan pediatric population, among others. The 44 patients involved in the research were between 2 and 3 years old. Six of them (13.64%) had Down syndrome. VSD patients who were later subjected to surgical correction were more likely to be able to avoid irreversible pulmonary artery hypertension [72].
According to another, Chinese publication, the association of trisomy 21 is also high in the case of complete AVSD (CAVSD). In a group of 35 patients with this type of anatomical deviation, Zhong et al. performed chromosome tests in 15 cases. A total of 13 chromosome abnormalities (86.67%) have been reported, of which 11 patients with Down syndrome have been identified [73].
Relatively few studies deal with long-term follow-up of Fallot tetralogy cases. According to Shuhaiber et al., the prospects can be positive for those who are being treated surgically in the case of the disease. In their study, however, they also refer to the related VSD and the high proportion of trisomy 21 (80.33%, according to their calculations) in their combined occurrence [74].
In cases of other cardiac abnormalities and anomalies of the large blood vessels, the risk of chromosome abnormality is increased [75]. Paladini et al. [70] studied the incidence of the chromosome anomalies in cases of other cardiac and large blood vessel malformations. In the case of coarctation of the aorta, the incidence rate of abnormal chromosomes was 48.28%; in the case of double outlet right ventricle, it was 26.32%; in the case of hypoplastic left heart syndrome, it was 13.51%; in the case of truncus arteriosus, it was 33.33%; in the case of Fallot tetralogy, it was 45%; and in the case of atrial septal defect, there were no abnormal karyotypes found [70].
Other researchers also produced statistics for other heart disorders. Chromosome abnormalities were detected in six cases when investigating 33 fetuses [30].
Only a few authors studied the isolated hydrothorax. Nicolaides carried out karyotyping in three cases because of isolated hydrothorax, in connection with an invasive intervention (blood gained by fetoscopy) performed due to other positive ultrasound findings, and found abnormal karyotype in one case [20]. Estoff et al. carried out karyotyping in 11 cases because of isolated hydrothorax, and in 1 case they found an abnormal karyotype (trisomy 21, 9.09%) [76]. In other studies, in two out of six (33.33%) cases, one case of trisomy 18 (16.67%) and one case of monosomy X (16.67%) associations were observed [30].
In the case of diaphragmatic hernia, abdominal organs appear in the chest due to a discontinuity in the compartment. About 90% of the lesion is on the left. The aperture of the compartment is not traceable; the abdominal organs of the fetus (liver, stomach, and intestines) appear in the chest, which dislocate the mediastinum and the heart. Chest space narrowing may lead to severe lung hypoplasia.
In cases of an omphalocele, organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord; the opening is in the center (median) of the abdominal wall, where the umbilical cord meets the abdomen.
Among the abdominal wall malformations, gastroschisis is a full-thickness defect of the abdominal wall, typically to the right of the umbilical cord, not including it. Through the open abdominal cavity, the small and large intestines protrude; there is no amnioperitoneal membrane covering the exposed organs.
During the ultrasound screening, the “double bubble” is a characteristic sign of duodenal atresia. The two “bubbles” are the distended stomach and dilated proximal duodenum.
Regarding anomalies of the abdominal wall and abdomen, the structural malformations associated with chromosome abnormalities are omphalocele and duodenal atresia. In cases with echogenic bowel—which is a marker and not necessarily abnormal in itself—the risk of trisomy 21 is higher [77, 78, 79, 80]. The etiology of echogenic bowel could be other rare abnormalities (cystic fibrosis, atresia) in addition to the more frequent intrauterine infections [81].
Blancato et al. [82] demonstrated earlier (1992) by in situ hybridization the occurrence of tissue-specific mosaicism in some cases of diaphragmatic hernia. While during lymphocyte culturing there are no detectable anomalies (blood samples via cordocentesis or blood testing of the newborn), in cases of fibroblast samples (genetic amniocentesis and dermal biopsy), 12p isochromosome can be found. Donnenfeld et al. [83] carried out chromosome analysis in 15 cases of diaphragmatic hernia. In all cases they performed lymphocyte culturing (in 14 cases of fetal cordocentesis) in addition to the fibroblast tests. They found chromosome anomalies in seven cases (46.67%), of which there were three cases of trisomy 18, three cases of 12p mosaicism, and one case of other abnormality [83]. From the seven cases of anomalies, there were two with different results of the cells of different origins due to the mosaicism, and the 12p isochromosome was only detectable from the fibroblasts (amniocentesis and dermal biopsy) and not from the lymphocytes gained from the blood. In five cases, the examinations of the lymphocytes and the fibroblasts gave the same results (three cases of trisomy 18, one case of unbalanced translocation, and one case of 12p isochromosome). Huddy et al. studied 35 cases of diaphragmatic hernia, they examined the outcome of the pregnancy and the related abnormalities, and they found chromosome anomalies in 4 cases altogether (11.43%), of which 2 were trisomy 18 [84].
Many authors studied the abdominal malformations and the other anomalies associated with them. According to all data of the literature, the omphalocele (or exomphalos) is associated with chromosome abnormalities in high rates, mainly with trisomy 18, and in smaller proportion with trisomy 13.
Mann et al. in their study of obstetrical events associated with abdominal malformations reported 7 cases of chromosome abnormalities of 19 cases of omphalocele (36.84%) [85]. Rabe et al. processed the results of similar number of ultrasonographic screening during pregnancy, and in 17 omphalocele cases, they have found 6 chromosome anomalies (35.29%) [86]. Nicolaides et al. in 1986 with a smaller number of cases (8 chromosome abnormalities of 12 cases) [20] and later Gilbert and Nicolaides in 1987 with 19 chromosome anomalies of 35 cases demonstrated [87] that the omphalocele detected by ultrasonographic screening increases the risk of chromosome abnormalities.
Many other scientists verified the results of these studies. Nyberg et al. [88] demonstrated chromosome abnormalities in 10 of 26 cases (38.46%), Holzgreve et al. [89] in 5 of 10 cases (50%), Rizzo et al. [90] in 7 of 12 cases (58.33%), and Fogel et al. [91] in 5 of 37 cases. In their recent study with a higher number of cases, Nicolaides et al. detected abnormal karyotypes in 42 of 116 omphalocele cases (36.21%); 32 cases of these were trisomy 18 (27.59%) and in 7 cases trisomy 13 (6.03%) [92]. Snijders et al. [93] found in higher rate abnormal karyotype, mainly trisomy 18, in 12 of 18 cases (66.67%). The following studies demonstrated almost the same results, Dillon and Renwick [94] in 12 of 43 cases (27.91%), Axt et al. [95] in 7 of 26 cases (26.92%), and Rankin et al. [96] in 30 of 98 cases (30.61%), while Stoll et al. [97] have found abnormal karyotypes in 17 cases out of 58 cases (29.31%). The majority of the abnormal karyotypes were trisomy 18. Axt et al. found the risk of chromosome abnormalities four times higher when the liver was placed intracorporeally than when in the extracorporal placement [95]. Barisic et al. [98] processed the data of 19 European centers and described 34 abnormal karyotypes in total for 137 omphalocele cases (24.82%). Most of the chromosomal abnormalities were trisomy 18 (21 cases, 15.33%); they described a lower rate of trisomy 13 (5 cases, 3.65%), one case of trisomy 21 and monosomy X, two cases of triploidy, and four cases of other chromosomal abnormalities. Salihu et al. [99] processed 29 cases, and 3 abnormal karyotypes were detected (10.34%); in all cases the liver was located intracorporeally.
In the study of Beke et al., out of 21 fetuses diagnosed with omphalocele, two cases (9.52%) were associated with different karyotypes, 1 case trisomy 18, and 1 case trisomy 13 [30].
Many investigators studied the gastroschisis cases in parallel with the omphalocele screenings, even though some of the studies were carried out with a smaller number of cases, so the results are not consistent. Rankin et al. found 1 case of chromosome abnormality in 133 gastroschisis cases (trisomy 13, 0.75%) [96]. Barisic et al. [98] also found abnormal karyotypes in 1.89% at a higher number of cases; they described chromosomal abnormalities in 2 out of the total 106 cases, of which 1 was trisomy 21 and the other was trisomy 13.
Other studies with a smaller number of cases did not indicate chromosome abnormalities; Mann et al. [85] studied 10 cases, Nicolaides et al. [20, 92] 3 and 26 cases, Dillon et al. [94] 56 cases, and Axt et al. [95] 18 cases, and they could not detect any abnormal karyotype. Stoll et al. [97] studied 47 cases of gastroschisis, while Salihu et al. [99] described 15 cases; in these cases there were no abnormal karyotypes detected.
Gastroschisis is often associated with other anomalies. Along with polyhydramnios, special attention should be paid to the ultrasound examination of the fetus. This was observed by Ozawa et al. [100] in a study involving the analysis of 52 fetuses. A quarter of them had trisomy (13 cases, 25%), particularly high rates of Edwards syndrome detected in 10 cases, while Patau syndrome in 2 cases and trisomy 21 in 1 case [100].
In contrast, Stoll et al. [101] diagnosed only one fetus with chromosome abnormality in the case of gastroschisis (trisomy 21) representing 1.16% of the patients studied. They also stated that the etiology of omphalocele and gastroschisis is unclear and their pathogenesis is controversial [101].
The ultrasonographic mark of the duodenal obstruction is the “double bubble.” The disease is not always detected intrauterine; therefore some investigators involved the subsequently proven, postnatal cases to their study. Studies demonstrated that it mainly increases the risk of trisomy 21. Nicolaides et al. studied 23 cases and found chromosome abnormalities in 10 cases (43.48%) [92]. Bailey et al. detected 15 cases of chromosome anomalies of the 138 cases (trisomy 21) (10.87%) [102]. This rate at Heydanus et al. was 7 abnormal karyotypes out of 29 cases (24.14%), 6 of which were trisomy 21 [103]. Lawrence et al. found 11 cases of chromosome anomalies of also 29 cases (37.93%), in 8 cases trisomy 21 [104]. Beke et al. found abnormalities in 2 out of 17 studied cases (11.76%), including a trisomy 21 [30].
It is controversial in international literature whether the karyotyping is justified in cases of echogenic bowel. Nyberg et al. was the first to draw the attention to the echogenic bowel increasing mainly the risk of trisomy 21 [105]. Subsequently Scioscia et al. reported 6 cases of chromosome abnormalities of 22 chromosome analyses associated with echogenic bowel (27.27%); in 5 cases trisomy 21 and in 1 case trisomy 18 were found [79]. Bromley et al. carried out 50 karyotyping associated with echogenic bowel and detected abnormal chromosomes in eight cases (16%), six cases of trisomy 21, one case of trisomy 13, and one case of monosomy X [77]. Sipes et al. studied seven cases and detected one case (14.3%) of trisomy 18 [81].
There were two greater studies fully investigating the expectable risk in association with echogenic bowel.
Slotnick and Abuhamad [106] separately screened the different measures of echogenity in their study published in Lancet, classifying them this way: grade1, mild increase of echogenity; grade2, moderate increase; and grade3, pronounced increase. They carried out altogether 145 karyotyping because of echogenic bowel and found abnormal karyotypes (all trisomy 21) in eight cases (5.5%). There were 6 cases of trisomy 21 of the 24 grade3 cases (25%), 2 positive cases of the 81 grade2 cases (2.47%), and no chromosome abnormalities of the 40 cases of grade1. They also studied the incidence of cystic fibrosis, they found 5 cases at grade3 and 2 cases at grade2, and they did not detect any cystic fibrosis at grade1 [106].
Strocker et al. [80] studied those cases separately, where the increasing bowel echogenity was associated with other malformations. They detected abnormal karyotypes in 15 cases of altogether 131 cases (11.45%). In 62 cases, the echogenic bowel was not associated with other positive ultrasonographic findings; in this group, there were 5 chromosome anomalies found, in 4 cases trisomy 21 (6.45%) and 47, XXY karyotype in 1 case. In the other group, there were 69 cases associated with other ultrasonographic findings; 10 of these cases carried chromosome abnormalities, 8 cases trisomy 21 (11.59), 1 case triploidy, and 1 case deletion X [80].
According to the observation of Beke et al., chromosome abnormalities were detected in only 3 out of 53 cases (5.66%), when the ultrasound image of the echogenic bowel was not isolated but associated with other defects [30].
Nicolaides et al. [92] also examined other abdominal malformations. In his study there were 24 cases of karyotyping due to lack of a visible stomach, and he found an abnormal karyotype in 18 cases (75%). In other 24 cases of chromosome analyses due to intestinal dilatation, there was 1 with abnormality (4.17%) [92].
Pyelectasis is the dilatation of only the renal pelvis and the calyces, in milder cases, while when the parenchyma is also affected by the longer lasting compression (becoming thinner), hydronephrosis develops. Obstructions of the urinary tract usually result in the dilatation of the proximal sections. Obstruction of the ureteropelvic junction is the main cause of hydronephrosis in the neonates.
According to some authors, an increase in the size of the renal pelvis elevates the risk of aneuploidies (mainly trisomy 21) [107, 108, 109, 110]. We measure the renal pelvis in a horizontal section in the anteroposterior (AP) direction. We define renal pelvis dilatation (pyelectasis) as a pelvis with an AP dimension ≥5 mm. Hydronephrosis (a renal pelvis ≥10 mm) and enlarged, echogenic kidneys increase the risk of trisomy 13.
Benacerraf et al. [107] studied 210 cases of fetuses with pyelectasis. They found trisomy 21 in 7 of the 210 cases (3.33%). The suggested criteria for pyelectasis were the following cutoff values, ≥4 mm until week 20 and ≥5 mm in weeks 21–30, and after week 30 the limit should be ≥7 mm [107]. Corteville et al. studied 127 cases and detected chromosome abnormalities in 7 cases (5.51%), 4 of these were trisomy 21 (3.15%) [109]. They suggested that until week 33 the cutoff value should be ≥4 mm; after week 33 this limit would be ≥7 mm. Under comparable conditions (121 cases, similar cutoff values), Wickstrom et al. found chromosome anomalies in three cases (2.48%), two of which were trisomy 21 (1.65%) [111].
Nicolaides et al. reported in their study 35 abnormal karyotypes that are found in cases of 258 fetuses with pyelectasis (13.57%) [92]. Their recommended cutoff value was ≥5 mm as a criteria for pyelectasis. Chudleigh et al. carried out chromosome analysis using 5 mm cutoff value in 737 cases of fetal pyelectasis. Studying the results of the karyotyping, they found abnormal chromosomes in 12 cases (1.63%), and 6 of these were trisomy 21 (0.81%) [108]. Besides less number of cases, other scientists did not verify the higher rate of chromosome anomalies. Gonen et al. found no abnormal karyotypes in 58 cases of fetal pyelectasis [8].
Beke et al. [30] processed 302 cases, of which 7 (2.32%) were found to have abnormalities. Of these, 1-1 cases of trisomy 21 and trisomy 18, two cases of monosomy X, and three cases of other chromosome abnormalities were found [30].
According to the findings of a 2006 study, contrary to previous opinions that male fetuses had a higher rate of chromosome abnormalities associated with pyelectasis, they refuted this. According to this new article by Bronstein et al. [112], there is no significant difference between the sexes in the karyotype associated with the anatomical disorder. When investigating 672 cases, 35 (5.21%) cases of abnormal karyotype occurred [112].
Based on Coco’s and Jeanty [113]’s findings, pyelectasis alone does not justify an amniocentesis if it is not associated with anatomical and other abnormalities. However, 3.01% of their cases were associated with chromosome abnormalities as well [113].
Measuring the length of fetal femur and more recently the humerus is part of the biometric test. Following the limbs of the fetus, the joints, the hands, and the feet and their deviations can be brought into the field of vision. Limb disorders may appear independently or as part of syndromes, causing extensive ossification anomalies. Most disorders can be rarely recognized prenatally.
On the basis of several studies of cases with shortened long bones (femur and humerus), the incidence rate for the abnormal karyotypes is elevated. According to the literature, a shortened humerus is a more sensitive indicator. Mainly the risk of trisomy 21 increases [114, 115, 116, 117].
Studying the long bones, the main ambition of the investigators was to determine the proper method to estimate the measure of the retardation in growth, which increases the risk of chromosome abnormalities. The two main methods are fundamentally different. Some investigators calculate with the observed/expected ratio (O/E ratio) and determine the proper cutoff value by expressing the quotient in percentile (≤0.91) [8, 115]. Other scientists calculate on the basis of the quotient of biparietal diameter (BPD) and femur length (FL) (BPD/FL) and consider abnormal the measure of >1.5 SD [114]. Calculating with both methods, most investigators found significant differences between the fetal groups of normal chromosomes and those with chromosome abnormalities. According to some authors, the difference was not significant [118, 119].
Nyberg et al. [115] examined separately the parameters (O/E ratio) in the case of the humerus and femur and suggested the following cutoff values: humerus ≤0.89 and femur ≤0.91. If both the femur and the humerus are shortened according to the given cutoff values, the risk of trisomy 21 increased 11-fold [115].
Recent studies include both methods. In their report Snijders et al. draw the attention to the fact that although they found significant differences using both methods (O/E ratio, BPD/FL) between fetal groups of normal karyotype and trisomy 21, the screenings before week 18 of gestation are less suitable to predict trisomy 21 [116]. Vergani et al. [117] did not find a significant difference between measuring the O/E ratio and using the BPD/FL method; the difference reached the significance limit (p = 0.04). According to their report, the measurement of femur length is connected with the population, and each center should determine the cutoff values dependent on the population on their own [117].
According to a study, chromosome abnormalities occurred in 16% in cases of shortened tubular (long) bones, including 8% of trisomy 18 and 4-4% of monosomy X and trisomy 21 [30].
A Danish publication processed the data of 2718 fetuses detected with shortened femur between the gestational weeks of 17–22, of which 2.5% had chromosome abnormalities. In 11 cases, trisomy 21, in 3 cases trisomy 13, and in 8 cases trisomy 18 were found. Chromosome abnormalities were associated with a higher proportion of these anatomical disorders in the second trimester than the first trimester [120].
Other malformations of the extremities increase the risk of trisomy 21 (clinodactyly, widened pelvic angle, sandal gap), trisomy 13 (postaxial polydactyly, clubbed or rocker-bottom feet), and trisomy 18 (clenched hands, overlapping digits, radial aplasia, limb shortening, clubbed feet) [48].
Ultrasound examinations play an important role during pregnancy, by drawing the attention to the suspect of a possible abnormality. The prenatal screening of minor ultrasound signs and major ultrasound anomalies and diagnostics is a very important part of the health service. The intrauterine screening and diagnostic methods, the ultrasound screening during the pregnancy, and the cytogenetic and molecular genetic examinations in the genetic centers made the early, intrauterine diagnosis of the chromosomal abnormalities possible.
The authors declare no conflict of interest.
Concrete filled steel tubes columns (CFST) are composite structures. They feature a variety of advantages. CFST have significant constructive, technological, economic advantages and at the same time an architecturally expressive appearance [1, 2, 3, 4, 5]. Such obvious CFST advantages as decreased labor consumption of their production due to lack of forms and reinforcement cages and high speed of building erection are quite attractive for construction specialists. Besides, mechanical features of a steel shell and a concrete core combine quite rationally in these columns. The strong steel shell serves as a reliable frame for the concrete core ensuring good volumetric load conditions for it. Due to this, concrete strength of columns with circular cross-section increases 1.8÷2.5 times in average. Concrete, in its turn, protects the walls of the steel shell from loss of stability and corrosion from inside. As a result, concrete and steel mutually increase load-carrying ability of each other and that of the whole element.
In case of emergency (explosions, earthquakes, etc.), another important feature of such columns, high survivability, comes to the fore. It is ensured by high deformability of the concrete core, which, together with its high strength, ensures absorption of large amounts of energy during strength resistance of the construction. Therefore, CFST of circular cross-section are increasingly used in construction practice.
The high strength and deformability of the concrete core ensure its main advantages, especially for short centrally loaded circular cross-section concrete-filled tubular elements. Due to the complicated nature of CFST load resistance, regulations of the Europe, Australia, Brazil, India, Canada, China, the USA, Japan, and a number of other countries recommend using empirical formulas to calculate their bearing capacity.
Despite the large number of the experiments serving as a base for these formulas they do not always allow to obtain valid results [6, 7]. They have significant limitations in the field of application. They were obtained either from the results of specific laboratory sample testing, or due to statistical processing of the relevant data. First, these formulas are valid only for normal concrete. They give unreliable results for the columns from other types of concrete (for example, fine-grained ones). Secondly, these methods, as a rule, do not allow the calculations of eccentrically compressed concrete filled steel tube elements, which have any differences from a “classical” design, for example, the presence of a high-strength rod [8, 9] and (or) spiral reinforcement [10, 11, 12], the application of various types of concrete [13], the effect of preliminary lateral reduction in a concrete core [14], etc.
According to the results of researches carried out by many scientists, the most reliable calculations of the strength of CFST columns can be performed based on the recommendations of the EN 1992-1-1 standard. Moreover, a simplified method is often used in the calculations. But it is based on empirical formulas and is very limited in scope. It is proposed to consider the general case of calculation as well. For its implementation, the following assumptions are made:
internal forces are determined by elasto-plastic analysis;
plane sections may be assumed to remain plane;
contact strength between steel and concrete components must be maintained up to column failure;
the tensile strength of concrete is neglected.
Design of column structural stability should take into account second-order effects including residual stresses, yielding of structural steel and of reinforcement, local instability, cracking of concrete, creep and shrinkage of concrete, geometrical imperfections.
However, there are no specific methods for practical implementation of such a calculation.
The purpose of this monograph is to propose the method of deformation calculation of the bearing capacity of compressed CFST under short-term load action based on the phenomenological approach.
Initially, the diameter
where
For monolithic columns, the possibility of loss of stability of the tube wall at the stage of installation of the supporting structures of the frame should be taken into account. The steel tube can be used as a supporting structure for several overlying floors even before it is filled with concrete, which significantly speeds up the process of constructing a building. In this case, local buckling is impossible when
If condition (2) is not met, it is necessary to check the stability of the tube walls under the action of corresponding loads. For this purpose, for example, the recommendations of European norm procedure (EN 1993-1-1 Steel Design) can be used.
For a short centrally loaded CFST column, the cross-sectional strength is usually determined. Most researchers use a fairly simple formula for this
where
Thus, in order to calculate the CFST strength, it is necessary to know the values of the strength of the volumetrically loaded concrete core and the compression in the steel shell. Various approaches and relationships for determining
Compression strength is a very important mechanical attribute of CFST concrete core. In the limiting state centrally loaded circular section column, concrete is in the conditions of three-axis compression by axial direction strain
A quite simple relationship, being in fact the Mohr-Coulomb strength condition, is most often used in calculations for such conditions
where
Considering experiments, the value of the
Though the Eq. (4) was recommended by American researches F. Richard, A. Brandtzæg and R. Brown as far back as in 1929, it is currently used by many researches, including for designing columns with different types of confinement reinforcement. The relationships to determine the volumetrically loaded concrete recommended by regulations in many countries have been obtained based on this very formula. However, the gained new experimental materials evidence that the Eq. (4) does not always allow to get a valid result.
This is caused by many reasons. One of them is inaccuracies in determination of lateral strain
in which
where
A similar dependence was proposed in [15].
Regarding such approach as conceptually correct, it is worth mentioning a quite limited range of CFST cross section diameters, where usage of relationships (6) allows to obtain a result acceptable for practical purposes. According to this formula, first,
Considering the results of the research [16], the coefficient
where
This formula does not need any limitations in a quite wide range of
Another reason of the results obtained by the Eq. (4) not always corresponding to experimental data is the value of the coefficient of lateral pressure
Some of researches recommend considering this point. For example, in the research [18] it was correctly mentioned that, other factors being equal, the value of the coefficient of lateral pressure decreases while this pressure increases. A formula is recommended for its determination
However, recently a formula of J. Mander has been used more frequently than others [19].
This formula was received based on the results of statistical processing of a large amount of experimental data and is usable for not only medium- but also high-strength concrete with
However, two main disadvantages of the Eq. (9) should be mentioned. First, lateral pressure
Processing of a number of experimental data evidences the existence of a stable relationship between
The appropriate formulas are used in Chinese Technical Code for CFST structures (GB50936–2014).
Two methods to assess state of stress in a steel shell are known. The first one hypothesizes that a steel tube acts only transversely in limit state. In this case, the axial direction compression in the steel shell
In the limiting state, the stress intensity in the steel shell reaches the yield point. During the central compression of a short CFST element, the steel shell experiences a compression-tension-compression stress state. Radial compressive stresses in the wall of steel tubes with
where
Then the stress
Let us mention that the Eq. (12) is correct for thin-shell tubes when d/δ ≥ 40. These very tubes are generally used as steel shells for CFST.
The hoop stresses averaged by thickness in the steel shell for thin-shell tubes can be expressed through the lateral pressure by the following relationship with accuracy sufficient for practical calculations
Consequently, the axial direction compression in the steel shell depend on its yield stress
The literature review shows that obtaining a reliable formula for determining the strength of volumetric compressed concrete of CFST elements is not an easy task. Most often, empirical formulas, which have significant limitations depending on the conditions of carried out experiment, are used. In case of structural changes or the use of new types of concrete and steel grades, other formulas will be needed. In this case, it is necessary to correctly determine the lateral pressure of a steel tube
In this regard, it is important to obtain theoretically based, universal formulas for determining
where
The average values of strength of normal concrete, calculated with a reliability of 50%, correspond to the coefficients
The analysis of relationship (14) shows that with high levels of sidework (with
Inserting the Eq. (14) into the Eq. (5) and performing some transformations, we will obtain:
where
Using the relationship (12) and performing some little manipulations, we can write the Eq. (12) as follows
The formula for
It is obvious that the total axial force received by concrete and steel with standard cross-section depends only on relative lateral pressure
Diagrams of changes of relative compressive forces received by concrete (1) and the steel shell (2) and their sum (3) depending on
Figure 1 shows that the graph of the total force change has a maximum point. The maximum compressive force can be found from the equation
As a result of solving Eq. (19), the following formula was obtained
Thus, the necessary formulas to calculate the strength of a short centrally loaded CFST have been received.
The construction of CFST columns can be improved by placing spiral reinforcement in the concrete core (Figure 2). This will have a positive effect on the strength and survivability of columns. A spiral, installed at some distance from the inner surface of the steel tube, can also increase the fire resistance of columns. Experimental studies [10, 11, 20] confirm the high efficiency of such structures.
Reinforce concrete filled steel tube column construction.
The widespread practical use of reinforced CFST columns is constrained by the lack of reliable methods for determining their strength. In work [12], a numerical finite element analysis of the load resistance of compressed CFST elements with spiral reinforcement was carried out. But empirical formulas were used here to determine the strength of concrete and lateral pressure on concrete in the limiting state.
The strength of short centrally compressed reinforced CFST column can be determined by formula:
where
Under the action of axial compressive force
First, the load resistance of a spirally reinforced concrete element that does not have an external steel tube is considered. As a result, the strength of concrete with confinement reinforcement
To determine the strength of the concrete core
The value of relative lateral pressure
where
where
The following formula for calculating the value
in which,
The value
where
The values of coefficients of transverse deformations
Then the strength of spirally reinforced concrete core
The lateral pressure on the concrete from the steel tube acts outside the diameter of the spiral
Depending on
In order to simplify the calculations it is offered to use the averaged design compressive strength of concrete core
where
The stress
in which
The compressive stress in the longitudinal reinforcement
In a number of earlier published works it is shown that the most reliable calculations of the bearing capacity of CFST columns, taking into account their design features, can be carried out on the basis of nonlinear deformation model. The calculation sequence of similar designs for deformation model is in detail stated in [16].
The calculations are based on the assumptions specified in the EN 1992-1-1 standard. They are listed in the introduction. While processing the experimental data the values of random eccentricity are taken three times less than the values recommended by standards for design purposes. Thus, the centering of the samples along the physical axis is taken into account.
The calculation is based on the relationships between stresses and strains for the concrete core
Tension of steel tube and concrete core of the central compressed CFST column: a – scheme of loading; b – at low loading levels; c – at high loading levels.
At the first stage, the deformation diagrams of the concrete core and the steel tube are constructed for the axial direction of the element. For this purpose, the load resistance of a short centrally compressed CFST element is considered. Load is imposed quickly. The concrete core is considered as a transversely isotropic body. The steel tube is considered to be an isotropic body. In the tube the stresses arise in the axial, circumferential and radial directions –
Curvilinear deformation diagrams are accepted for the concrete core. The coordinates of vertex of each diagram depend on the lateral pressure on the concrete from the steel tube. It is assumed that with an increase of the compressive force
Branch of concrete deformation charts at step-by-step strengthening of axial deformations: 1 - uniaxial compression, 2,3 - volume compression at the intermediate stages of deformation; 4 - volume compression in a limit state.
The coordinates of vertex of each diagram determine the strength of the concrete core (uniaxially compressed
There are many proposals for determining the strain
Let’s show how one can get the corresponding formula based on the phenomenological approach.
Figure 5 shows the stress–strain diagram of compressed concrete, corresponding to the maximum reached stress and compare it with the uniaxial compressed concrete diagram. It follows from the above that the initial modulus of elasticity
The graphs of deformation for uniaxial compressed (1) and volume-compressed (2,3) concrete.
The strain
Elastic strain
Plastic strain
where
The parameter
Thus, the total deformation of the volume-compressed concrete at the maximum stress is determined by the formula
The performed statistical analysis showed that the best match with the results of the experiments corresponds to a value of
where
According to the recommendations of [21] the ultimate strain of a volume-compressed concrete is determined by the formula
where
When coordinates of parametric points of the deformation charts of volumetrically compressed concrete are known, it is possible to calculate the bearing capacity of CFST columns based on the deformation model analysis.
To construct the diagrams
The analytical relationship between strains and stresses for any point of the concrete core is written in the form of a system of equations:
The elastic–plastic properties of concrete are taken into account by the coefficients of elasticity
The values of the intensity of stresses and strains are calculated using the well-known formulas of solid mechanics. Using the coefficients of elasticity
The stress state of a steel tube obeys the hypothesis of a uniform curve [22]. In accordance with this hypothesis, the dependence
The initial diagram
Generalized calculation diagram of steel, operating under conditions of complex stress state.
Parameter of diagram | Steel classes according to the set of rules Russia - SP 16.13330.2018 | |||||
---|---|---|---|---|---|---|
S245, S255 | S285 | S345, S345К, S375 | S390 | S440 | S590, S590К | |
0,80 | 0,80 | 0,80 | 0,90 | 0,90 | 0,90 | |
0,92 | 0,92 | 0,92 | 1,00 | 1,00 | 1,00 | |
1,70 | 1,70 | 1,70 | 1,70 | 1,70 | 1,70 | |
1,00 | 1,00 | 1,00 | 1,00 | 1,00 | 1,00 | |
14,0 | 15,0 | 16,0 | 17,0 | 17,0 | 18,0 |
Coordinates of characteristic points of the generalized steel deformation diagram, constructed in the axes
Communication between strains and stresses for any point of an external steel shell in elastic and elasto-plastic stages can be presented the following equations system:
Here
The stresses and strains acting on the principal planes are used in Eqs. (37) and (38). Experiments show [16] that in the stage of yield Chernov-Luders lines appear on the surface of the steel tube. These lines are angled 45° to the longitudinal axis of the CFST. Therefore, shear stresses and shear strains are equal to zero here.
The stress–strain states of the concrete core and steel tube largely depend on the values of the coefficients of transverse strain and the coefficients of elasticity of the materials. Therefore, their reliable determination is very important when calculating the strength of CFST columns. Formulas for calculating these coefficients are given in work [16].
The solution of the Eqs. (37) and (38), taking into account the joint deformation of concrete and steel tube, allows obtaining the formula for calculating the lateral pressure
in which
When the strain
After that we compare the last value of strain
Upon termination of calculations we receive arrays of numerical data for deformation charting of concrete core
At the second stage, the bearing capacity of the eccentrically loaded CFST element is calculated. The design scheme of the normal section of element is shown in Figure 7.
Design model of the normal section of the CFST element deformations of the normal cross section is designed, corresponding to the equilibrium condition of the calculated element. In order to develop such a diagram it is required to find the corresponding value of the strain of the least compressed (stretched).
In the calculation process, the deformation of the most compressed fiber of the concrete core
The normal section of the calculated element is conditionally divided into small sections with areas of concrete
The origin of coordinates is aligned with the geometric center of the element’s cross section. If the Bernoulli hypothesis is observed, there is a strain in the center of each section of concrete and steel tube. With known strains, the corresponding stresses are determined according to the results of the first stage of the calculation. The stresses are assumed to be evenly distributed within each section of concrete and steel tube. After each step of strain
in which
When both equilibrium conditions are met, the value of the compressive force
The problem of determining the strength reduces to finding the value of the strain of the most compressed fiber
The proposed method makes it possible to limit the axial strains of the columns. It is known from experiments that the strain of compressed CFST elements can reach 5 ÷ 10% [16]. With such strains, the operation of the columns of the buildings becomes impossible. Thus, excessive strain can determine the ultimate limit state of the CFST column. The maximum permissible values of these strains can be set by a structural engineer, depending on a specific design situation for a designed building or a structure.
Due to the complex nature of load resistance of CFST columns, in design practice, as a rule, the simplified methods of calculation of their bearing capacity are used. At that, flexibility is usually taken into account by the coefficient of longitudinal bending, determined according to empirical relationships. In the monograph we consider the deformation calculation of CFST column bearing capacity.
A rod of a circular cross-section with a constant length, loaded by a compressive force N applied to the ends with the same initial eccentricity
The scheme of a compressed rod deformation.
According to the known positions of structural mechanics, if we apply force N along the axis that coincides with the physical gravity center of an elastic rod cross-section, the rod will remain a rectilinear one until the force reaches the value of the critical load Nu corresponding to the moment of stability loss. Only after that the middle part of the rod will receive the corresponding deflection
A bending moment
where
With the increase of the bending moment, the strength of a compressed rod normal section decreases, which must be taken into account during the calculation. On the other hand, the axial load increase to a critical value in the columns of great flexibility can lead to a very significant increase of transverse deformations - the loss of stability of the second kind. With a certain transverse deflection, the compressive load reaches a maximum value, after which its decrease is observed with a further deflection increase (Figure 9). At the same time, the strength properties of materials from which the column is made will not be implemented fully.
The dependence of compressive force on deflection
The main assumptions that are directly relevant to this study are the following ones:
the calculation is based on the theory of small displacements;
the shear deformations are neglected in comparison with the bending deformations of the rod axis;
the distribution of deformations along a cross section corresponds to the hypothesis of plane cross sections.
The flexibility of the column is determined for the reduced cross-section. For the base case under consideration, this flexibility can be approximated by the following formula:in which
It is recommended to calculate the stiffness
where
Flexibility can have a significant effect on the load capacity of compressed elements when the condition
where
The compressive stress in the longitudinal reinforcement
The calculation is based on the step-iteration method. During the second stage, an eccentrically loaded compressed element is divided along its length into n equal segments, at that
The design scheme of a flexible pipe-concrete column: a - the decomposition of the compressed rod along the length; b - distribution diagrams of concrete relative deformations in Section 2 and 3.
The area of one rod of longitudinal reinforcement is
At each step, the relative deformation of the least compressed (stretched) fiber
where N is the longitudinal compressive force corresponding to the accepted deformation diagram;
Cross-section stiffnesses
The effect of longitudinal bending is taken into account via the eccentricity of the longitudinal force increase by the amount of rod deflection
where
An improved deflection value
The numerical solution of the problem of calculating the deflection [16] with the number of partitions n = 6 allows us to obtain the following formula
where
The problem under consideration is solved as follows. The deviations y of the longitudinal axis of the compressed rod from the vertical are calculated in the sections at the boundaries of each segment into which an element is divided with the deflection found in the first approximation according to the formula
Then the distribution of the relative deformations is established for these cross-sections, using the Eqs. (49) and (50) and by the replacement of
the equilibrium of the normal section, i.e. the observance of equalities by the Eqs. (49) and (50);
the constancy of the longitudinal force value, which is assumed to be the same as for the mean most stressed section.
Let’s note that the stiffness characteristics
After the determination of
They record the value of the compressive longitudinal force
According to the proposed method, the algorithm for estimate the stress–strain state and calculate the load-bearing capacity of compressed concrete filled steel tube elements was developed and this algorithm was implemented in the computer program. The results of the calculations are compared with the experiment data of CFST samples made of normal concrete. These data were obtained by many researchers for 569 experiments with short centrally compressed columns, 512 flexible centrally compressed columns and 292 eccentrically compressed elements.
Experimental data was taken from research works [16, 23, 24].
In order to obtain more objective information, the experimental data of samples were analyzed with a large range of geometric and structural parameter variation:
an outer diameter of an outer steel shell −
the thickness of an outer steel shell wall −
the yield point of a shell steel −
the prismatic strength of the initial concrete −
various concretes (normal, ultrahigh-strength, pre-stressing);
length to diameter ratio
the relative eccentricity of the longitudinal force
The results of the comparison show a completely satisfactory coincidence of experimental destructive loads with theoretical values (Table 2).
Type of tested elements | No of tests | Average Test/Calculate | Stand. Deviation Test/Calculate |
---|---|---|---|
Short No Moment | 569 | 1.04 | 0.068 |
Long No Moment | 512 | 1.08 | 0.077 |
Long and Short with Moment | 292 | 1.06 | 0.072 |
The overall | 1373 | 1.07 | 0.073 |
Summary of Comparison of Calculated Bearing Capacity with Experimental Data.
The data in Table 2 show a good agreement between theory and practice.
According to the results of the data of work [23], the calculations according to Eurocode 4 (EN 1994-1-1: 2004) have a slightly worse accuracy. However, the main advantage of the proposed calculation method is its versatility. In particular, when using this method, one can take into account the presence of a high-strength rod and (or) spiral reinforcement, the effect of preliminary lateral compression of the concrete core [16]. The research work [13] verified the acceptability of the EN 1994-1-1: 2004 method for calculating the strength of compressed CFST made of various types of concrete: normal, ultrahigh-strength, self-compacting, light-weight concretes and engineered cementitious composite. It is concluded that the calculation accuracy is satisfactory only for normal concrete. The proposed method makes it possible, with an appropriate selection of the material coefficients
Based on the results of the carried out analysis, the following values of the coefficients of materials for various types of concrete can be recommended:
for fine grained and for ultrahigh-strength concrete –
for self-compacting concrete –
for lightweight concrete and for engineered cementitious composite –
Given recommendations are preliminary and need to be clarified, since they have been obtained on the basis of processing a very limited amount of experiments.
The analysis of the results of the carried out researches shows that there are very significant advantages of the nonlinear deformation model in comparison with the currently used methods for calculating the bearing capacity of CFST columns. The proposed calculation method takes into account the complex stress state of the concrete core and steel tube, which is constantly changing with increasing load, and the physical and geometric nonlinearity of the structure. In the course of the calculation, it is possible to obtain a clear picture of the stress–strain state of the structure at various stages of loading.
The main dependences for finding the strength and strain characteristics of a concrete core and a steel tube are obtained phenomenologically. They correspond to the basic principles of solids mechanics. The resulting formulas are more universal than empirical dependencies. For example, they are true for different types of concrete. In principle, the developed method is applicable for calculating the bearing capacity of composite columns with various cross-sectional shapes and various variants of reinforcement of a concrete core. Differences in designs are easily taken into account when developing calculation algorithms for specific tasks.
The use of a multi-point method for constructing the diagrams of concrete deformation allows improving the accuracy of calculations. Previously, these diagrams were accepted either for uniaxially compressed concrete, or for volumetrically compressed concrete at the stage of ultimate equilibrium of the structure. In the first case the value of the bearing capacity turned out to be underestimated, and in the second case - overestimated.
The proposed criterion for achieving the bearing capacity of CFST columns is important for practical calculations. The use of this criterion makes it possible to identify the cases when the strength properties of a concrete core cannot be fully used. Calculation by the method of limiting efforts does not always reflect the physical essence of the process and can lead to significant errors.
From the point of view of modern concepts of solid mechanics, steel-reinforced concrete structures refer to nonlinear and non-equilibrium deformable systems. The feature of such system calculation is the need to refine the values of the existing forces and displacements consistently, since the internal forces and the rigidity of the structures are interdependent.
The proposed method of CFST load capacity calculation allows to take into account these features. Considering flexibility the higher stiffness of the compressed rod is taken into account at the sites located closer to its supports. In this regard, it is obvious that the correct implementation of this method in practice will allow to obtain more reliable calculation results in comparison with the currently used semi-empirical approach.
Besides, this method makes it possible to perform the calculations of normal cross section and stability strength from a unified point of view. During the calculation, it is possible to track (in terms of longitudinal deformation value) the completeness of concrete and steel strength property use. If the material deformations reach the maximum permissible values, it can be concluded that the strength of the structures is lost. If this is not observed in the loss of the load-bearing capacity of the structure, a conclusion can be made about the loss of stability of the second kind.
It is especially important, that the proposed method with an appropriate refinement can be used for calculating the compressed structures made of various constructional materials.
One more important circumstance should be noted. It is known that in CFST columns, even before the onset of complete loss of bearing capacity, axial deformations can reach excessively large values at which the operation of real structures becomes impossible. In these cases, the limiting deformation can become dominant, determining ULS. In this regard, during the calculation of bearing capacity the axial deformations of the compressed CFST elements should be limited. This approach can be implemented only when calculating with the use of a nonlinear deformation model of reinforced concrete.
The proposed method can be effectively used to calculate long-term load columns [25].
A new technique to determine the strength of compressed CFST was proposed. Based on the known principles of deformation calculation, it takes into account the specific features of CFST adequately. The methodology uses new dependencies to determine the strength and the ultimate deformation of a concrete core, as well as the way of concrete deformation diagram development. It allows to perform the combined calculation of CFST strength, taking into account their flexibility and the calculation of possible stability loss. There is no need for an empirical formula to determine the critical force proposed by modern design standards for composite structural steel structures in the practical application of the method.
The versatility of this method should be emphasized separately. The method is acceptable for CFST columns made of various types of concrete using various technologies.
The practical use of the proposed method gives a reliable estimate of the stress–strain state and the strength of concrete filled steel tube columns.
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The two case studies show different possibilities for interrogating the city to provide a spatially and socially grounded way of co-producing knowledge for action that can contribute to the planning of just urban futures.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Rita Lambert and Adriana Allen",authors:[{id:"183462",title:"Dr.",name:"Adriana",middleName:null,surname:"Allen",slug:"adriana-allen",fullName:"Adriana Allen"},{id:"184062",title:"Dr.",name:"Rita",middleName:null,surname:"Lambert",slug:"rita-lambert",fullName:"Rita Lambert"}]},{id:"51416",doi:"10.5772/64250",title:"Satellite SAR Interferometry for Earth’s Crust Deformation Monitoring and Geological Phenomena Analysis",slug:"satellite-sar-interferometry-for-earth-s-crust-deformation-monitoring-and-geological-phenomena-analy",totalDownloads:1441,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Synthetic aperture radar interferometry (InSAR) and the related processing techniques provide a unique tool for the quantitative measurement of the Earth’s surface deformation associated with certain geophysical processes (such as volcanic eruptions, landslides and earthquakes), thus making possible long-term monitoring of surface deformation and analysis of relevant geodynamic phenomena. This chapter provides an application-oriented perspective on the spaceborne InSAR technology with emphasis on subsequent geophysical investigations. First, the fundamentals of radar interferometry and differential interferometry, as well as error sources, are briefly introduced. Emphasis is then placed on the realistic simulation of the underlying geophysics processes, thus offering an unfolded perspective on both analytical and numerical approaches for modeling deformation sources. Finally, various experimental investigations conducted by acquiring SAR multitemporal observations on areas subject to deformation processes of particular geological interest are presented and discussed.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Giuseppe Solaro, Pasquale Imperatore and Antonio Pepe",authors:[{id:"4222",title:"Dr.",name:"Pasquale",middleName:null,surname:"Imperatore",slug:"pasquale-imperatore",fullName:"Pasquale Imperatore"},{id:"99269",title:"Dr.",name:"Antonio",middleName:null,surname:"Pepe",slug:"antonio-pepe",fullName:"Antonio Pepe"},{id:"182234",title:"Ph.D.",name:"Giuseppe",middleName:null,surname:"Solaro",slug:"giuseppe-solaro",fullName:"Giuseppe Solaro"}]},{id:"51731",doi:"10.5772/64527",title:"Estimation and Uncertainty Assessment of Surface Microclimate Indicators at Local Scale Using Airborne Infrared Thermography and Multispectral Imagery",slug:"estimation-and-uncertainty-assessment-of-surface-microclimate-indicators-at-local-scale-using-airbor",totalDownloads:1469,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"A precise estimation and the characterization of the spatial variability of microclimate conditions (MCCs) are essential for risk assessment and site-specific management of vector-borne diseases and crop pests. The objective of this study was to estimate at local scale, and assess the uncertainties of Surface Microclimate Indicators (SMIs) derived from airborne infrared thermography and multispectral imaging. SMIs including Surface Temperature (ST) were estimated in southern Quebec, Canada. The formulation of their uncertainties was based on in-situ observations and the law of propagation of uncertainty. SMIs showed strong local variability and intra-plot variability of MCCs in the study area. The ST values ranged from 290 K to 331 K. They varied more than 17 K on vegetable crop fields. The correlation between ST and in-situ observations was very high (r = 0.99, p = 0.010). The uncertainty and the bias of ST compared to in-situ observations were 0.73 K and ±1.42 K respectively. This study demonstrated that very high spatial resolution multispectral imaging and infrared thermography present a good potential for the characterization of the MCCs that govern the abundance and the behavior of disease vectors and crop pests in a given area.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Serge Olivier Kotchi, Nathalie Barrette, Alain A. Viau, Jae-Dong\nJang, Valéry Gond and Mir Abolfazl Mostafavi",authors:[{id:"31099",title:"Prof.",name:"Mir Abolfazl",middleName:null,surname:"Mostafavi",slug:"mir-abolfazl-mostafavi",fullName:"Mir Abolfazl Mostafavi"},{id:"181360",title:"Ph.D.",name:"Serge Olivier",middleName:null,surname:"Kotchi",slug:"serge-olivier-kotchi",fullName:"Serge Olivier Kotchi"},{id:"188549",title:"Dr.",name:"Nathalie",middleName:null,surname:"Barrette",slug:"nathalie-barrette",fullName:"Nathalie Barrette"},{id:"188550",title:"Dr.",name:"Alain A.",middleName:null,surname:"Viau",slug:"alain-a.-viau",fullName:"Alain A. Viau"},{id:"188551",title:"Dr.",name:"Jae-Dong",middleName:null,surname:"Jang",slug:"jae-dong-jang",fullName:"Jae-Dong Jang"},{id:"188552",title:"Dr.",name:"Valery",middleName:null,surname:"Gond",slug:"valery-gond",fullName:"Valery Gond"}]},{id:"51786",doi:"10.5772/64528",title:"GIS Applications in Agronomy",slug:"gis-applications-in-agronomy",totalDownloads:3022,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Agronomy is a branch of agriculture that deals with soil and crop. Soil varies in space and is responsible for variation in the growth and yield of crops on the field. This variation in the yields of crops planted and monitored on the same parcel of land under the same environmental conditions has been a great concern to farmers. Spatial variations of soil nutrients status, as caused by topography, soil texture and management practices, have been observed across the fields. Hence, the need to separate the field into site specific management units using geographical information systems (GIS) for effective soil and crop management in order to obtain optimum productivity. Over the years, field sizes, farming direction, locations of fences, rotations and fertility programmes have changed the nutritional status of the farms. Consequently, the productivity of the soil has equally been affected. In spite of these factors, conventional agriculture treats an entire field uniformly with respect to the application of fertiliser, pesticides, soil amendments and other chemical application. The use of GIS will help farmers to overcome over- or under-applications of fertiliser and other agrochemical applications. The potential of GIS application in agronomy is obviously large. However, the GIS user community in the field of agronomy is rather small compared to other business sectors. To advance the use of GIS in agronomic studies, this Chapter in book tends to explore the applications of GIS to some fields in agronomy.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Suarau O. Oshunsanya and OrevaOghene Aliku",authors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"},{id:"176082",title:"Mr.",name:"OrevaOghene",middleName:null,surname:"Aliku",slug:"orevaoghene-aliku",fullName:"OrevaOghene Aliku"}]}],mostDownloadedChaptersLast30Days:[{id:"62267",title:"Identification of Karst Forms Using LiDAR Technology: Cozumel Island, Mexico",slug:"identification-of-karst-forms-using-lidar-technology-cozumel-island-mexico",totalDownloads:949,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Morphological relief analysis allows the identification of geomorphological forms and cartographic-environmental studies make extensive use of the medium (1:50,000) and large scale (1:250,000), where the topographical contrast is evident. However, at a detailed scale (<1:20,000) and for territories where the contrast of relief does not exceed 10 m in height, the morphological analyses must be adapted accordingly, because they contribute information to altimetry studies and to the topographic configuration of units. Thus, through visual interpretation and manipulation of high-resolution topographical LiDAR data from Cozumel Island, a relief analysis is presented at a detailed scale for the purpose of recognizing the geomorphological units of karst origin, using altimetry and slope cartography, digital models of elevation, and shading that permits the identification of 109 new exokarstic doline and uvala formations.",book:{id:"7465",slug:"trends-in-geomatics-an-earth-science-perspective",title:"Trends in Geomatics",fullTitle:"Trends in Geomatics - An Earth Science Perspective"},signatures:"Oscar Frausto-Martínez, Norma Angelica Zapi-Salazar and Orlando\nColin-Olivares",authors:[{id:"185429",title:"Dr.",name:"Oscar",middleName:null,surname:"Frausto-Martinez",slug:"oscar-frausto-martinez",fullName:"Oscar Frausto-Martinez"},{id:"258227",title:"MSc.",name:"Orlando",middleName:null,surname:"Colin - Olivares",slug:"orlando-colin-olivares",fullName:"Orlando Colin - Olivares"},{id:"258228",title:"MSc.",name:"Norma Angélica",middleName:null,surname:"Zapi - Salazar",slug:"norma-angelica-zapi-salazar",fullName:"Norma Angélica Zapi - Salazar"}]},{id:"64109",title:"Mathematical Analysis of Some Typical Problems in Geodesy by Means of Computer Algebra",slug:"mathematical-analysis-of-some-typical-problems-in-geodesy-by-means-of-computer-algebra",totalDownloads:922,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"There are many complicated and fussy mathematical analysis processes in geodesy, such as the power series expansions of the ellipsoid’s eccentricity, high order derivation of complex and implicit functions, operation of trigonometric function, expansions of special functions and integral transformation. Taking some typical mathematical analysis processes in geodesy as research objects, the computer algebra analysis are systematically carried out to bread, deep and detailed extent with the help of computer algebra analysis method and the powerful ability of mathematical analysis of computer algebra system. The forward and inverse expansions of the meridian arc in geometric geodesy, the nonsingular expressions of singular integration in physical geodesy and the series expansions of direct transformations between three anomalies in satellite geodesy are established, which have more concise form, stricter theory basis and higher accuracy compared to traditional ones. The breakthrough and innovation of some mathematical analysis problems in the special field of geodesy are realized, which will further enrich and perfect the theoretical system of geodesy.",book:{id:"7465",slug:"trends-in-geomatics-an-earth-science-perspective",title:"Trends in Geomatics",fullTitle:"Trends in Geomatics - An Earth Science Perspective"},signatures:"Hou-pu Li and Shao-feng Bian",authors:[{id:"141289",title:"Prof.",name:"Shao-Feng",middleName:null,surname:"Bian",slug:"shao-feng-bian",fullName:"Shao-Feng Bian"},{id:"141296",title:"Dr.",name:"Hou-Pu",middleName:null,surname:"Li",slug:"hou-pu-li",fullName:"Hou-Pu Li"}]},{id:"51786",title:"GIS Applications in Agronomy",slug:"gis-applications-in-agronomy",totalDownloads:3022,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Agronomy is a branch of agriculture that deals with soil and crop. Soil varies in space and is responsible for variation in the growth and yield of crops on the field. This variation in the yields of crops planted and monitored on the same parcel of land under the same environmental conditions has been a great concern to farmers. Spatial variations of soil nutrients status, as caused by topography, soil texture and management practices, have been observed across the fields. Hence, the need to separate the field into site specific management units using geographical information systems (GIS) for effective soil and crop management in order to obtain optimum productivity. Over the years, field sizes, farming direction, locations of fences, rotations and fertility programmes have changed the nutritional status of the farms. Consequently, the productivity of the soil has equally been affected. In spite of these factors, conventional agriculture treats an entire field uniformly with respect to the application of fertiliser, pesticides, soil amendments and other chemical application. The use of GIS will help farmers to overcome over- or under-applications of fertiliser and other agrochemical applications. The potential of GIS application in agronomy is obviously large. However, the GIS user community in the field of agronomy is rather small compared to other business sectors. To advance the use of GIS in agronomic studies, this Chapter in book tends to explore the applications of GIS to some fields in agronomy.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Suarau O. Oshunsanya and OrevaOghene Aliku",authors:[{id:"175778",title:"Dr.",name:"Suarau",middleName:null,surname:"Oshunsanya",slug:"suarau-oshunsanya",fullName:"Suarau Oshunsanya"},{id:"176082",title:"Mr.",name:"OrevaOghene",middleName:null,surname:"Aliku",slug:"orevaoghene-aliku",fullName:"OrevaOghene Aliku"}]},{id:"51468",title:"Increasing the Adaptive Capacity of Indigenous People to Environmental Change: The Potential Use of an Innovative, Web-Based, Collaborative-Geomatics Informatics Tool to Reduce the Degree of Exposure of First Nations Cree to Hazardous Travel Routes",slug:"increasing-the-adaptive-capacity-of-indigenous-people-to-environmental-change-the-potential-use-of-a",totalDownloads:1433,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The arctic and subarctic regions of Canada are experiencing amplified climate change impacts, which are disproportionately impacting Canadian indigenous populations’ ability to safely travel on land to acquire resources. Less predictable and more dangerous travel conditions are impacting not only the health and safety of individuals but also the traditional lifestyles that are vital to the cultural well-being of these indigenous communities. The University of Waterloo’s Computer Systems Group has developed a novel decision-support tool termed “Collaborative-Geomatics.” This web-based informatics tool can allow for the community to monitor, in real-time, the safety of travel routes. Using handheld GPS tracking systems, the utility of the geomatics system to present real-time travel conditions was carried out in a Canadian First Nations community, located along the Western James Bay coast. The results of this study showed that the collaborative-geomatics tool offers the potential to monitor and store information on the safety of travel routes, helping to promote adaptive capacity and aid in knowledge transfer within arctic and subarctic indigenous communities.",book:{id:"5246",slug:"geospatial-technology-environmental-and-social-applications",title:"Geospatial Technology",fullTitle:"Geospatial Technology - Environmental and Social Applications"},signatures:"Christine D. Barbeau, Donald Cowan and Leonard J.S. Tsuji",authors:[{id:"181883",title:"Ph.D. Student",name:"Christine",middleName:null,surname:"Barbeau",slug:"christine-barbeau",fullName:"Christine Barbeau"},{id:"186196",title:"Dr.",name:"Don",middleName:null,surname:"Cowan",slug:"don-cowan",fullName:"Don Cowan"}]},{id:"64719",title:"Architectural Design and Prototyping of Co-PPGIS: A Groupware-Based Online Synchronous Collaborative PPGIS to Support Municipality Development and Planning Management Workflows",slug:"architectural-design-and-prototyping-of-co-ppgis-a-groupware-based-online-synchronous-collaborative-",totalDownloads:1064,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Co-PPGIS has a wide variety of applications like municipal planning, emergency response, public health and security, etc. The main focus of this chapter is on the development and design of a Web Collaborative PPGIS (Co-PPGIS) infrastructure. As part of municipality’s planning and management services, Co-PPGIS is developed for real-time map sharing application system. Co-PPGIS is an effective and essential online meeting system for supporting group collaborations on geographic information such as maps and imageries, and capturing and sharing of local/domain knowledge in real time. Co-PPGIS permits amalgamation of geospatial data and collaborator’s input in the form of geo-referenced notations. It incorporates coherent components as map sharing, real-time chat, video conferencing, geo-referenced textual and graphical notations. The study aims to focus on public participation and geo-collaboration facilitated with information sharing, interactive geo-conferencing, real-time map, and data sharing with tools to draw features or add annotation to the map while discussions, uploading documents, and live communication. Co-PPGIS provides an efficient and reliable platform that will significantly reduce the time to acquire, process, and analyze data. The significance of this study is to contribute to existing public participation practices, to municipal planning, to decision-making, or to geographic information science.",book:{id:"7465",slug:"trends-in-geomatics-an-earth-science-perspective",title:"Trends in Geomatics",fullTitle:"Trends in Geomatics - An Earth Science Perspective"},signatures:"Muhammad A. Butt, Syed Amer Mahmood, Javed Sami, Jahanzeb\nQureshi, Muhammad Kashif Nazir, Amer Masood, Khadija Waheed\nand Aysha Khalid",authors:[{id:"3899",title:"Mr.",name:"Syed Amer",middleName:null,surname:"Mahmood",slug:"syed-amer-mahmood",fullName:"Syed Amer Mahmood"},{id:"242037",title:"Dr.",name:"M. Atif",middleName:null,surname:"Butt",slug:"m.-atif-butt",fullName:"M. Atif Butt"},{id:"269239",title:"Mr.",name:"Javed",middleName:null,surname:"Sami",slug:"javed-sami",fullName:"Javed Sami"},{id:"269240",title:"Mr.",name:"Jahanzeb",middleName:null,surname:"Qureshi",slug:"jahanzeb-qureshi",fullName:"Jahanzeb Qureshi"},{id:"269241",title:"Mr.",name:"Amer",middleName:null,surname:"Masood",slug:"amer-masood",fullName:"Amer Masood"},{id:"270009",title:"Mr.",name:"Muhammad Kashif",middleName:null,surname:"Nazir",slug:"muhammad-kashif-nazir",fullName:"Muhammad Kashif Nazir"}]}],onlineFirstChaptersFilter:{topicId:"785",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"May 11th, 2022",hasOnlineFirst:!1,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. 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This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. 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Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR"},{id:"25",title:"Evolutionary Computation",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Artificial Intelligence",id:"14"},selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. 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