General phenotypic features of mycolate genera classified in the order
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8939",leadTitle:null,fullTitle:"Urban Horticulture - Necessity of the Future",title:"Urban Horticulture",subtitle:"Necessity of the Future",reviewType:"peer-reviewed",abstract:"Urban horticulture is a means of utilizing every little space available in cities amidst buildings and other constructions for growing plants. It utilizes this space to raise gardens that can be economically productive while contributing to environmental greening. It can boost food and ornamental plants production, provide job opportunities, promote green space development, waste recycling, and urban landscaping, and result in improved environment. This book covers a wide array of topics on this subject and constitutes a valuable reference guide for students, professors, researchers, builders, and horticulturists concerned with urban horticulture, city planning, biodiversity, and the sustainable development of horticultural resources.",isbn:"978-1-83880-513-5",printIsbn:"978-1-83880-512-8",pdfIsbn:"978-1-83880-631-6",doi:"10.5772/intechopen.82900",price:119,priceEur:129,priceUsd:155,slug:"urban-horticulture-necessity-of-the-future",numberOfPages:180,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"5db1ff90f7e404baf4e42cdfbe0b9755",bookSignature:"Shashank Shekhar Solankey, Shirin Akhtar, Alejandro Isabel Luna Maldonado, Humberto Rodriguez-Fuentes, Juan Antonio Vidales Contreras and Julia Mariana Márquez Reyes",publishedDate:"June 17th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8939.jpg",numberOfDownloads:12306,numberOfWosCitations:4,numberOfCrossrefCitations:16,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:25,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:45,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 29th 2019",dateEndSecondStepPublish:"August 23rd 2019",dateEndThirdStepPublish:"October 22nd 2019",dateEndFourthStepPublish:"January 10th 2020",dateEndFifthStepPublish:"March 10th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"210702",title:"Dr.",name:"Shashank Shekhar",middleName:null,surname:"Solankey",slug:"shashank-shekhar-solankey",fullName:"Shashank Shekhar Solankey",profilePictureURL:"https://mts.intechopen.com/storage/users/210702/images/system/210702.jpeg",biography:"Dr. Shashank Shekhar Solankey is presently working as Assistant Professor–cum–Jr. Scientist (Horticulture: Vegetable Science) at Bihar Agricultural University (BAU), Sabour (Bhagalpur), India. He received a doctorate in Horticulture from Banaras Hindu University, Varanasi. He has more than seven years of experience in teaching and research. His research focus is improvement of vegetable crops, especially tomato and okra. Dr. Solankey was awarded the Best Teacher Award and Best Researcher Award in 2016 by BAU, and has twelve other prestigious awards. He has published fifty-five research/review papers, one souvenir paper, six books, one abstract book, and thirty-three book chapters. He is young, dynamic, and wishes to flourish in the field of academia and publications.",institutionString:"Bihar Agricultural University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Bihar Agricultural University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"295101",title:"Dr.",name:"Shirin",middleName:null,surname:"Akhtar",slug:"shirin-akhtar",fullName:"Shirin Akhtar",profilePictureURL:"https://mts.intechopen.com/storage/users/295101/images/system/295101.jpeg",biography:"Dr. Shirin Akhtar is an enthusiastic and young faculty member at Bihar Agricultural University (BAU), Sabour, Bhagalpur, India. Her field of specialization is vegetable breeding. She received a PhD from Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, West Bengal. Her areas of research are biotic and abiotic stress resistance as well as quality improvement in vegetables, particularly solanaceous crops and okra. She is engaged in teaching undergraduate, postgraduate, and PhD courses and mentoring postgraduate and doctoral students towards new research ideas. She has authored two books, ten book chapters, more than forty research articles in journals of national and international repute, and several popular articles and folders.",institutionString:"Bihar Agricultural University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Bihar Agricultural University",institutionURL:null,country:{name:"India"}}},coeditorTwo:{id:"105774",title:"Prof.",name:"Alejandro Isabel",middleName:null,surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado",profilePictureURL:"https://mts.intechopen.com/storage/users/105774/images/system/105774.jpeg",biography:"Dr. Alejandro Isabel Luna Maldonado received a PhD in Agricultural Sciences from Kyushu University, Fukuoka, Japan, in 2009. He began his career as a lecturer in the Department of Agricultural Engineering at the Autonomous University of Nuevo León in 1992 and was trained in the design and automation of agro-industrial machinery at the Japan International Cooperation Agency. Professor Luna Maldonado became an assistant professor in 1996 and a professor in 2018. He has published thirty-three articles, five book chapters, and four books. He has advised six doctoral theses, five master\\'s theses, and three undergraduate theses. He has served as the head of the educational program of Food Industry Engineering, which has been internationally accredited by Accreditation Board for Engineering and Technology (ABET), since 2009. He has been a member of the Mexican Council of Science and Technology since 2012, and the Program for the Development Teaching Professional (PRODEP) since 2003. He has also been a member of the American Society of Agricultural Engineering since 2012, and the Japanese Society of Agricultural Machinery since 2007.",institutionString:"Universidad Autónoma de Nuevo León",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Universidad Autónoma de Nuevo León",institutionURL:null,country:{name:"Mexico"}}},coeditorThree:{id:"130491",title:"Dr.",name:"Humberto",middleName:null,surname:"Rodriguez-Fuentes",slug:"humberto-rodriguez-fuentes",fullName:"Humberto Rodriguez-Fuentes",profilePictureURL:"https://mts.intechopen.com/storage/users/130491/images/system/130491.jpeg",biography:"Dr. Humberto Rodriguez-Fuentes is Professor of Environment and Sustainability at the Autonomous University of Nuevo León, Mexico. He graduated with a doctorate in Agricultural Sciences with a specialty in Water-Soil from the same university. He has forty years of experience in teaching and research. His research is mainly focused in the area of plant factories for the production of highly nutritious vegetables. Since 1990 he has been a national researcher distinguished by the government of Mexico in Biotechnology and Agricultural Sciences. He has published six textbooks, twelve book chapters, and more than fifty articles in journals with strict national/international arbitration. He is also the editor of three books with international distribution.",institutionString:"Universidad Autónoma de Nuevo León",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Universidad Autónoma de Nuevo León",institutionURL:null,country:{name:"Mexico"}}},coeditorFour:{id:"215230",title:"Dr.",name:"Juan Antonio",middleName:null,surname:"Vidales Contreras",slug:"juan-antonio-vidales-contreras",fullName:"Juan Antonio Vidales Contreras",profilePictureURL:"https://mts.intechopen.com/storage/users/215230/images/system/215230.jpeg",biography:"Juan Antonio Vidales Contreras, MSc, PhD is an agricultural engineer. Since 1985, he has been a full-time professor at the School of Agronomy at the Autonomous University of Nuevo Leon (UANL), Mexico. He received an Agronomy Engineer degree at the same university on 1984. His PhD was awarded by the University of Arizona in 2001. Dr. Vidales Contreras has published more than fifty original research papers in indexed journals, five book chapters, and has participated and contributed in more than twenty scientific meetings.",institutionString:"Universidad Autónoma de Nuevo León",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Universidad Autónoma de Nuevo León",institutionURL:null,country:{name:"Mexico"}}},coeditorFive:{id:"299825",title:"Dr.",name:"Julia Mariana",middleName:null,surname:"Márquez Reyes",slug:"julia-mariana-marquez-reyes",fullName:"Julia Mariana Márquez Reyes",profilePictureURL:"https://mts.intechopen.com/storage/users/299825/images/system/299825.png",biography:"Julia Mariana Márquez Reyes obtained a PhD in Biotechnology from Autonomous University of Nuevo Leon (UANL), Mexico, in 2013. She specializes in bioreactors with anaerobic activity for the removal of contaminants, phytoremediation for the control of heavy metals in water and soil, enzymatic activity and antioxidant capacity of plant organisms used in environmental biotechnology, and development of sustainable technologies. She began her career as a lecturer of Balance of Matter and Energy, Unit Operations, Environmental Microbiology at UANL. Dr. Márquez Reyes became an assistant professor in 2018. She has been a member of the Mexican Council for Science and Technology since 2009. She has published six scientific papers and one book chapter.",institutionString:"Universidad Autónoma de Nuevo León",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Universidad Autónoma de Nuevo León",institutionURL:null,country:{name:"Mexico"}}},topics:[{id:"304",title:"Urban Agriculture",slug:"urban-agriculture"}],chapters:[{id:"70957",title:"Nutrients for Hydroponic Systems in Fruit Crops",doi:"10.5772/intechopen.90991",slug:"nutrients-for-hydroponic-systems-in-fruit-crops",totalDownloads:1520,totalCrossrefCites:5,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Hydroponic systems for crop production are nowadays essential to maximize yields. Sometimes, the benefits of hydroponics have been questioned by the researchers as compared to growing of crops in other soilless culture. The growers raised the crops through hydroponics system get yields more compared to conventional practices as hydroponically grown plants dip their roots directly into nutrient-rich solutions. Therefore, the aim of the current chapter is to provide accurate and updated information about their different nutrients and their composition used hydroponically compared to conventional production mode. This chapter will be divided as the following sections: (1) rationale, (2) nutrient solution technique, and (3) work done on fruit crops. With this chapter, we hope to present an updated information, comparing hydroponic versus conventional technique.",signatures:"Pramod Kumar and Simran Saini",downloadPdfUrl:"/chapter/pdf-download/70957",previewPdfUrl:"/chapter/pdf-preview/70957",authors:[{id:"253238",title:"Dr.",name:"Pramod",surname:"Kumar",slug:"pramod-kumar",fullName:"Pramod Kumar"},{id:"316834",title:"Ms.",name:"Simran",surname:"Saini",slug:"simran-saini",fullName:"Simran Saini"}],corrections:null},{id:"69007",title:"Hydroponic Systems for Arabidopsis Extended to Crop Plants",doi:"10.5772/intechopen.89110",slug:"hydroponic-systems-for-arabidopsis-extended-to-crop-plants",totalDownloads:916,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"When using Arabidopsis grown hydroponically for gene and drug discovery, a method for translating this approach to crop (and weed) species needs articulation and investigation. In this review, we describe existing inexpensive, frequently aseptic, hydroponic systems for Arabidopsis and compare them to other hydroponic methods for gene and drug discovery in crop plants. Besides gene and drug discovery, an important use of hydroponic analysis is for understanding growth in controlled, enclosed systems, such as during spaceflight and in simulated extra-terrestrial environments. When done initially with Arabidopsis, will these results apply to the growth of other species? We highlight the strengths and weaknesses of existing translational hydroponic approaches whereby results with Arabidopsis extend to other plant species. We find that the existing or slightly modified hydroponic approaches used in Arabidopsis research extend well to crop plants that grow upright about 40 cm in height, e.g., monocots, such as rice, and dicots, such as soybean. However, other, taller species such as maize, or vining species such as tomato, require extensive modification to provide larger enclosures and root stabilization.",signatures:"Lawrence Griffing and Krishna Kumar",downloadPdfUrl:"/chapter/pdf-download/69007",previewPdfUrl:"/chapter/pdf-preview/69007",authors:[{id:"302680",title:"Associate Prof.",name:"Lawrence",surname:"Griffing",slug:"lawrence-griffing",fullName:"Lawrence Griffing"},{id:"310017",title:"MSc.",name:"Krishna",surname:"Kumar",slug:"krishna-kumar",fullName:"Krishna Kumar"}],corrections:null},{id:"70662",title:"Automation and Robotics Used in Hydroponic System",doi:"10.5772/intechopen.90438",slug:"automation-and-robotics-used-in-hydroponic-system",totalDownloads:2848,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Hydroponic system requires periodic labor, a systematic approach, repetitive motion and a structured environment. Automation, robotics and IoT have allowed farmers to monitoring all the variables in plant, root zone and environment under hydroponics. This research introduces findings in design with real time operating systems based on microcontrollers; pH fuzzy logic control system for nutrient solution in embed and flow hydroponic culture; hydroponic system in combination with automated drip irrigation; expert system-based automation system; automated hydroponics nutrition plants systems; hydroponic management and monitoring system for an intelligent hydroponic system using internet of things and web technology; neural network-based fault detection in hydroponics; additional technologies implemented in hydroponic systems and robotics in hydroponic systems. The above advances will improve the efficiency of hydroponics to increase the quality and quantity of the produce and pose an opportunity for the growth of the hydroponics market in near future.",signatures:"Alejandro Isabel Luna Maldonado, Julia Mariana Márquez Reyes, Héctor Flores Breceda, Humberto Rodríguez Fuentes, Juan Antonio Vidales Contreras and Urbano Luna Maldonado",downloadPdfUrl:"/chapter/pdf-download/70662",previewPdfUrl:"/chapter/pdf-preview/70662",authors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"},{id:"215230",title:"Dr.",name:"Juan Antonio",surname:"Vidales Contreras",slug:"juan-antonio-vidales-contreras",fullName:"Juan Antonio Vidales Contreras"},{id:"299825",title:"Dr.",name:"Julia Mariana",surname:"Márquez Reyes",slug:"julia-mariana-marquez-reyes",fullName:"Julia Mariana Márquez Reyes"},{id:"220744",title:"MSc.",name:"Héctor",surname:"Flores Breceda",slug:"hector-flores-breceda",fullName:"Héctor Flores Breceda"},{id:"252026",title:"Dr.",name:"Humberto",surname:"Rodríguez-Fuentes",slug:"humberto-rodriguez-fuentes",fullName:"Humberto Rodríguez-Fuentes"},{id:"303920",title:"Prof.",name:"Urbano",surname:"Luna Maldonado",slug:"urbano-luna-maldonado",fullName:"Urbano Luna Maldonado"}],corrections:null},{id:"71186",title:"Application of Nanotechnology Solutions in Plants Fertilization",doi:"10.5772/intechopen.91240",slug:"application-of-nanotechnology-solutions-in-plants-fertilization",totalDownloads:1461,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Post-modern society is viewed nowadays as a technologized society, where the great solutions to human problems can be solved by the progress of technology in economics from classical industry to communications. In the last years, nanotechnology is called to play an important part in the global food production, food security and food safety in the sense that the use of nanoscale micronutrients conduced to suppressing crop disease and the relationship between nutritional status and plant diseases is investigated. Nanomaterials are capable to penetrate into cells of herbs; they can carry DNA and other chemical compounds in the cells extending the possibility in plant biotechnology to target special gene manipulation. It is important to note that the concentration, plant organ or tissue, exposure rate, elemental form, plant species, and exposure dosage (chronic/acute) affect the plant response and in particular the distinct stress response. The complex process of utilization nanoparticles in agriculture has to be monitored to a level that avoids further environmental contamination. The present and future use of nanoparticles as micronutrients is affected by different risks related to nanotoxicity of micronutrients, a problem to be solved by an appropriate and safe circuit of nanoparticles in soil, water, plants and at last in human organism.",signatures:"Daniela Predoi, Rodica V. Ghita, Simona Liliana Iconaru, Carmen Laura Cimpeanu and Stefania Mariana Raita",downloadPdfUrl:"/chapter/pdf-download/71186",previewPdfUrl:"/chapter/pdf-preview/71186",authors:[{id:"50919",title:"Dr.",name:"Rodica V.",surname:"Ghita",slug:"rodica-v.-ghita",fullName:"Rodica V. Ghita"},{id:"183930",title:"Prof.",name:"Daniela",surname:"Predoi",slug:"daniela-predoi",fullName:"Daniela Predoi"},{id:"313256",title:"Dr.",name:"Simona Liliana",surname:"Iconaru",slug:"simona-liliana-iconaru",fullName:"Simona Liliana Iconaru"},{id:"313258",title:"Dr.",name:"Carmen Laura",surname:"Cimpeanu",slug:"carmen-laura-cimpeanu",fullName:"Carmen Laura Cimpeanu"},{id:"313260",title:"Dr.",name:"Stefania Mariana",surname:"Raita",slug:"stefania-mariana-raita",fullName:"Stefania Mariana Raita"}],corrections:null},{id:"72163",title:"Nutritive Solutions Formulated from Organic Fertilizers",doi:"10.5772/intechopen.89955",slug:"nutritive-solutions-formulated-from-organic-fertilizers",totalDownloads:958,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter shows how organic fertilizers can provide essential nutrients soluble to plants, so as to be used in hydroponic systems in its various forms. Such materials are an important source of macro- and micronutrients. This form of plant nutrition can contribute to the sustainable production of food, both in developed and developing countries. Nutrient solutions can be formulated when soluble nutrients are extracted from the solid phase of organic manure. In some vegetables, equal yields, or sometimes higher, have been obtained in nutritive solutions formulated with synthetic chemical fertilizers. It has also been documented that the resulting edible products can be of a better nutraceutical quality. Ions can be obtained by means of preparations based on teas, extracts, leachates, digestate, urine, aquaculture, etc. Subsequently they must be diluted in water until reaching a level of electrical conductivity according to the tolerance levels of the crop to be established. The heterogeneity of the chemical composition of the solutions obtained is the main point that must be attended with the greatest possible precision to formulate the nutritive solutions and obtain satisfactory results. Therefore, it is necessary to measure the concentration of macro- and micronutrients (NO3−, NH4+, SO4=, H2PO4−, K+, Ca++, Mg++, Fe+++, Cu++, Mn++, Zn++, Cl−) as well as the Na+ ion (which is usually at high levels); it will also be necessary to adjust the pH. In addition, the chapter presents a broad overview and a series of research results in recent years: composition of solutions, nutrient supplements, substrates, and floating root trials in tomato, lettuce, cantaloupe melon, and green fodder. The environmental implications of inappropriate formulations are also analyzed. The nutritious solution, formulated from organic fertilizers, is not only an alternative for the nutrition of agricultural crops, but it also represents a more efficient way to use these resources.",signatures:"Juan Carlos Rodríguez Ortiz",downloadPdfUrl:"/chapter/pdf-download/72163",previewPdfUrl:"/chapter/pdf-preview/72163",authors:[{id:"304656",title:"Dr.",name:"Juan Carlos",surname:"Rodríguez Ortiz",slug:"juan-carlos-rodriguez-ortiz",fullName:"Juan Carlos Rodríguez Ortiz"}],corrections:null},{id:"70921",title:"Installation of Vegetable Based Roof Gardens in Schools From Recyclable Materials: A Study",doi:"10.5772/intechopen.90721",slug:"installation-of-vegetable-based-roof-gardens-in-schools-from-recyclable-materials-a-study",totalDownloads:605,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The study aimed to reflect on the socio-environmental issues and the action of the gardens in urban/school spaces, considering garden as a methodological instrument for the interdisciplinary activities related to family farming, using the descriptive methodology and study of literary review with proposals of gardens using recyclable materials depicted through images created using the software AutoCAD. Through the study, it was possible to plan gardens using recyclable materials in environments of small spaces. The crops employed will be vegetables for school meals. The activities carried out in the garden contribute to the change in the habits and attitudes of students regarding the perception they possess of nature, the formation of awareness of respect and care, the need to conserve the environment and stimulate the pursuit of improvement of quality of life in other ways of seeing the activities performed by their own parents in the field.",signatures:"Adriana Maria dos Santos, Mariana Paiva Baracuhy, Dermeval Araújo Furtado, Romulo Wilker Neri de Andrade, Jackson Rômulo de Sousa Leite and Fabiana Terezinha Leal de Morais",downloadPdfUrl:"/chapter/pdf-download/70921",previewPdfUrl:"/chapter/pdf-preview/70921",authors:[{id:"306826",title:"Dr.",name:"Adriana",surname:"Dos Santos",slug:"adriana-dos-santos",fullName:"Adriana Dos Santos"},{id:"310926",title:"Dr.",name:"Marina",surname:"Paiva Baracuhy",slug:"marina-paiva-baracuhy",fullName:"Marina Paiva Baracuhy"},{id:"310927",title:"Dr.",name:"Dermeval",surname:"Araújo Furtado",slug:"dermeval-araujo-furtado",fullName:"Dermeval Araújo Furtado"},{id:"310928",title:"Dr.",name:"Jackson",surname:"Rômulo De Sousa Leite",slug:"jackson-romulo-de-sousa-leite",fullName:"Jackson Rômulo De Sousa Leite"},{id:"310929",title:"MSc.",name:"Fabiana",surname:"Terezinha Leal De Morais",slug:"fabiana-terezinha-leal-de-morais",fullName:"Fabiana Terezinha Leal De Morais"},{id:"310930",title:"Mr.",name:"Romulo",surname:"Wilker Neri De Andrade",slug:"romulo-wilker-neri-de-andrade",fullName:"Romulo Wilker Neri De Andrade"}],corrections:null},{id:"70563",title:"Urban Horticulture in Sub-Saharan Africa",doi:"10.5772/intechopen.90722",slug:"urban-horticulture-in-sub-saharan-africa",totalDownloads:645,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Horticultural crops refer to fruits, vegetables, spices, and ornamental and medicinal plants which are rich sources of vitamins, minerals, and phytochemicals. Rapid urbanization and migration of rural populace to the more industrialized city center has led to poverty, malnutrition, low and insecure incomes, ill-health and other livelihood problems. These problems are mostly seen among the people residing in urban areas who have migrated from rural areas. Urban horticulture ensures food and nutrition security, healthy environment and sustainable livelihoods, employment generation, among others. As such, this chapter carried out an empirical review of the state of urban horticulture in cities across sub-Sahara Africa. This is to enumerate ways whereby the benefits of urban horticulture can be specified in the region. It concluded that governments in the different countries need the political will to actualize identified benefits of urban horticulture. The chapter then recommends sensitization of the pertinent stakeholders in countries across sub-Saharan Africa on the benefits of urban horticulture. Such stakeholders include politicians, policy makers and urban households. This is in order to integrate the concept into urban land use planning while carefully considering sustainability of the environment.",signatures:"Ifeoluwapo Amao",downloadPdfUrl:"/chapter/pdf-download/70563",previewPdfUrl:"/chapter/pdf-preview/70563",authors:[{id:"223341",title:"Dr.",name:"Ifeoluwapo",surname:"Amao",slug:"ifeoluwapo-amao",fullName:"Ifeoluwapo Amao"}],corrections:null},{id:"70892",title:"Soil Quality Problems Associated with Horticulture in the Southern Urban and Peri-Urban Area of Buenos Aires, Argentina",doi:"10.5772/intechopen.90351",slug:"soil-quality-problems-associated-with-horticulture-in-the-southern-urban-and-peri-urban-area-of-buen",totalDownloads:652,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Horticulture is the main productive activity of south Buenos Aires city peri-urban sector. This activity is carried out with intensive land use, based on the high use of inputs, which has generated important pollution and soil degradation problems. Soil degradation processes have their origin in the poor quality irrigation water (sodium bicarbonate) and in the indiscriminate use of fertilizers and organic fertilizers, without considering the requirements of the crop and soil analysis. The results of a large number of surveys in the area, specified in the following chapter, showed salinization, pH increase, structure quality loss, organic matter decrease and phosphorus hyperfertilization. On the other hand, urban gardens are increasingly common, that is, the production of vegetables for own consumption within the urban framework. In this case, the problems are related to the type of soils where it occurs, and they are in general highly modified lands that almost completely lost their natural characteristics and are usually not favorable for plant growth. The results from the cases studied in La Plata city showed that urban soils have low organic carbon content, high bulk density and high pH. In these soils, the horticultural production with agroecological base managed an increase in the organic carbon content and a decrease in the apparent density.",signatures:"Paladino Ileana, Sokolowski Ana Clara, Prack Mc Cormick Barbara, José Enrique Wolski and Rodríguez Hernán y Mauro Navas",downloadPdfUrl:"/chapter/pdf-download/70892",previewPdfUrl:"/chapter/pdf-preview/70892",authors:[{id:"310271",title:"M.Sc.",name:"Ileana",surname:"Paladino",slug:"ileana-paladino",fullName:"Ileana Paladino"},{id:"310288",title:"M.Sc.",name:"Ana Clara",surname:"Sokolowski",slug:"ana-clara-sokolowski",fullName:"Ana Clara Sokolowski"}],corrections:null},{id:"70915",title:"Historical Gardens as an Inspiration for the Future of Urban Horticultural Gardens",doi:"10.5772/intechopen.90350",slug:"historical-gardens-as-an-inspiration-for-the-future-of-urban-horticultural-gardens",totalDownloads:812,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Through\ufeffout the history people \ufeffincorporated designed gardens in their closest living environment. They shaped their environment in \ufeffsuch a way \ufeffas to make it more useful, pleasing, and nicer. The old ancient civilization already created gardens that amazed \ufeffanyone visiting the city—\ufeffa good example are the great cities of Mesopotamia with hanging gardens and city entrance gardens dedicated to flowers, shrubs, and trees, creating \ufeffa feeling of being in paradise. \ufeffRenaissance gardens brought a great diversity of new garden motifs and innovations, while \ufeffBaroque gardens presented the whole city in themselves, creating \ufeffgreen walls and green architecture. The nineteenth century \ufeffwith its industrial revolution offered \ufeffnew technologies, new way\ufeffs of designing and adjusting the nature to man’s need. The twentieth and twenty-first centur\ufeffies brought to us various ways to include green\ufeff elements ranging from small to large-scale in our living environment,\ufeff (from greenhouses in the parks to green walls inside the buildings). Through different motifs of historical gardens, we can find possibilities for \ufefftoday\ufeff’s and future urban horticultural gardens.",signatures:"Ines Babnik",downloadPdfUrl:"/chapter/pdf-download/70915",previewPdfUrl:"/chapter/pdf-preview/70915",authors:[{id:"310886",title:"Ph.D.",name:"Ines",surname:"Babnik",slug:"ines-babnik",fullName:"Ines Babnik"}],corrections:null},{id:"71024",title:"Implication of Urban Agriculture and Vertical Farming for Future Sustainability",doi:"10.5772/intechopen.91133",slug:"implication-of-urban-agriculture-and-vertical-farming-for-future-sustainability",totalDownloads:1889,totalCrossrefCites:5,totalDimensionsCites:9,hasAltmetrics:1,abstract:"Urban agriculture (UA) is defined as the production of agricultural goods (crop) and livestock goods within urban areas like cities and towns. In the modern days, the urbanization process has raised a question on the sustainable development and growing of urban population. UA has been claimed to contribute to urban waste recycling, efficient water use and energy conservation, reduction in air pollution and soil erosion, urban beautification, climate change adaptation and resilience, disaster prevention, and ecological and social urban sustainability. Therefore, UA contributes to the sustainability of cities in various ways—socially, economically, and environmentally. An urban farming technology that involves the large-scale agricultural production in the urban surroundings is the vertical farming (VF) or high-rise farming technology. It enables fast growth and production of the crops by maintaining the environmental conditions and nutrient solutions to crop based on hydroponics technology. Vertical farms are able to grow food year-round because they maintain consistent growing conditions regardless of the weather outside and are much less vulnerable to climate changes. This promises a steady flow of products for the consumers and a consistent income for growers. Various advantages of VF over traditional farming, such as reduced farm inputs and crop failures and restored farmland, have enabled scientists to implement VF on a large scale.",signatures:"Anwesha Chatterjee, Sanjit Debnath and Harshata Pal",downloadPdfUrl:"/chapter/pdf-download/71024",previewPdfUrl:"/chapter/pdf-preview/71024",authors:[{id:"312477",title:"Dr.",name:"Harshata",surname:"Pal",slug:"harshata-pal",fullName:"Harshata Pal"},{id:"316680",title:"Dr.",name:"Anwesha",surname:"Chatterjee",slug:"anwesha-chatterjee",fullName:"Anwesha Chatterjee"},{id:"316681",title:"Dr.",name:"Sanjit",surname:"Debnath",slug:"sanjit-debnath",fullName:"Sanjit Debnath"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5227",title:"Urban Agriculture",subtitle:null,isOpenForSubmission:!1,hash:"722ebe60b63f7c01577d063a3e39c36a",slug:"urban-agriculture",bookSignature:"Mohamed Samer",coverURL:"https://cdn.intechopen.com/books/images_new/5227.jpg",editedByType:"Edited by",editors:[{id:"175050",title:"Prof.",name:"Mohamed",surname:"Samer",slug:"mohamed-samer",fullName:"Mohamed Samer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8308",title:"Agricultural Economics",subtitle:"Current Issues",isOpenForSubmission:!1,hash:"138b8e4117a40c74fc41ec72d552fa9f",slug:"agricultural-economics-current-issues",bookSignature:"Surendra N. 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Loosely organized firms do non-repetitive work with handcraft methods, and use a contract system involving a serious of subcontractors. The products of the construction industry are immobile, unique, heavy and large, complex, durable and expensive. Characteristics of products changes project to project. Construction products not only takes long time to produce, but also produced and coordinated on-site; and this requires different schedules, programs and temporary solutions for each project.
Since, beginning with unpredictable site conditions and demand volatility, construction process bring high level of risk, a careful management of risks is very important in construction. Risk management is not only important for successfully completing the production process in construction industry, but also for achieving sustainability. Sustainable construction defined as creating a healthy built environment based on ecologically sound principles, and aims to create and operate a healthy built environment based on resource efficiency and ecological design [1]. A careful risk management means an effective using the resources and responsible management of a healthy built environment based on ecologically sound principles. Success lies in the details mean in sustainable construction all details require a careful design and production management.
The objective of this study is emphasizing the importance of risk management and defining affective risk management tools in construction. This study consists of two main sections. In the first section, characteristics of construction industry and construction risks are defined in detail. In the second section, the importance of risk management in building construction and risk management tools are evaluated. In this section, the focus of the study is the evaluation of risk management studies with a broad literature review of previous researches.
Construction has many characteristics common to both service and manufacturing industries. Although, construction is more like a service industry in some ways, because it does not accumulate significant amounts of capital when compared with industries such as steel, mining, transportation and petroleum; there are physical products, and often these are of overwhelming size, cost and complexity as the manufacturing industry. Success or failure in construction industry is by far more dependent on the qualities of its people than it is on technologies protected by patents out by the sheer availability of capital facilities as in service industries [2].
In construction industry, the product is immobile and produced at the point of consumption. Each project is site specific, produced and coordinated on-site, the contractor sets up the factory on-site. Besides, all the complexities inherent in different construction sites. Subsoil conditions, weather, surface topography, transportation, material supply, utilities and services, local subcontractors, available technologies and labor conditions are an innate part of construction. Execution of the project is influenced by social, natural and other locational conditions such as weather, labor supply and local building codes. The anticipation of future requirements is inherently difficult, since the service life of a facility is long. Changes of design plans during construction are uncommon, because of technological complexity and market demands [3, 4]. In a construction project, since site conditions can be unpredictable, unexpected natural events can negatively affect construction programs and schedules. Weather conditions, for the production process of construction, are the most important and unpredictable handicap [5]. One of the two different side effects of weather conditions is unexpected changes in weather might stop, slow down or destroy production. Confining the production process to mild seasons is the other side effect of changes in weather. Construction activities show a trend of seasonality, since it is difficult to execute outdoor activities in winter. Summer is the most active and highest season for all the projects in a contractor’s portfolio. Most of the production required to complete before winter, since winter is a problematic season [6].
The product is changeable in construction industry. It is one-of-a-kind, large, complex, durable and long lasting. There may be big value differences among the products. Production depends on a project and construction projects typified by the non-standardized nature by their diversity and complexity. The construction process is sometimes subject to the influence of highly variable and unpredictable factors. Nearly every facility requires a long time to complete and custom designed and constructed. To some degree, each construction project is unique and two projects cannot be the same. The vagaries of the construction site and the possibilities for creative and utilitarian variation combine to make each construction project a new and different experience. Both the design and construction of a facility required to satisfy the conditions peculiar to a specific site [3, 4].
Construction projects usually executed over a long period and have large budgets. In construction industry, demand is not regular; it is both seasonal and volatile. Construction industry is one of the industries, which is the most effected by the economic crisis. During economic crisis, demand decreases. Because of this, demand for a construction project is volatile. Irregular demand in construction leads construction firms that have difficulty in keeping their overhead down in the case of low demand. In the case of high demand, responding to the load of irregular demand forces the contractor to search for other organizational forms than the traditional forms used in manufacturing [6]. It brings uncertainty in decision-making when different production methods required or the project executed in different parts of the country or the world. Different types of products, such as dam, highway and high-rise building, executed at the same time is a source of uncertainty. Every project requires different design study and production results, which brings both uncertainty and high level of risk.
Construction is an industry that involves many different participants from different fields. Owner, design professional, contractor, subcontractors and material suppliers are vital elements of the construction project. A successful project can only achieved if interrelated roles of the participants coordinated effectively. During the life cycle of the project, beginning with the owner’s first contemplating a construction project to the completion, there are different types of works, vary in type and intensity, which makes the process complicated. A large number of labor specialties required in construction projects such as electrical installation, sanitary installation or thermal insulation. Cooperation of experts from different fields required, since most of these trades demand the knowledge and experience of experts and it is hard and long way for a contractor to gain this expertise through project experiences. When a problem arises, the solution will be different in a highway project, compared to a solution in a building project. Therefore, outside assistance is needed, such as consultants and subcontractors [6].
Production process in construction industry is less amenable to routinize, because products have diverse characteristics and executed over a long period. A construction firm can execute different types of projects, all of which require different production schedules and systems all at the same time. Hence, this makes the decisions of labor and machinery investments uncertain. Not only coordination of resources among different projects becomes a major problem, but also new schedules and programs are required for each new project. Since the industry requires short-term project objectives and flexibility, construction named a casual industry [6].
The specific characteristics of construction industry make the production process risky. Construction projects are time-consuming and intricate undertakings. There are several phases requiring a diverse range of specialized services during a total development of a project. Beginning with the planning phase, the process continues passing typical jobs through successive and distinct stages to project completion. The project demand input from such disparate areas, such as governmental agencies, financial organizations, architects, engineers, lawyers, contractors, material manufacturers and suppliers, insurance and surety companies and building tradesmen [3]. These various parties from different fields have to work together in harmony for successfully completing the project. The high performance green building delivery system requires close collaboration among the parties, much more than in conventional construction delivery system [1].
This study focuses on risk management in construction through the view of sustainability. For this purpose, in the first place a broad literature review of previous studies completed. After evaluation of the previous studies, specific characteristics of construction industry identified. Since, the characteristic of the industry form the basics of risk management in construction industry, risks of construction industry are analyzed. In the last section, the study focuses on the four different tools of risk management in construction.
Construction is often a hazardous undertaking work. Risk, as a multi-facet concept [11], is an uncertain event or condition [7] and can defined as the “probability that an adverse event occurs during a stated period of time” [8]. If risk occurs, it has either positive or negative effects on project objectives [7]. In the context of construction industry, according to Faber [9], it could be the likelihood of the occurrence of combination of events/factors or a definite event/factor, which occur during the whole process of construction to the detriment of project. Hertz and Thomas [10] defined construction risks as a lack of predictability about structure outcome or consequences in a decision or planning situation. It is the uncertainty associated with estimates of outcomes—there is a chance that results could be better than expected as well as worse than expected [11]. A risk means, for a construction contractor, an event that will cause costs that were not planned and from which no profit will result [12]. Risk may result substantial cost and time overruns that are detrimental the project objectives, and inherent to any construction project. Arising from delays and additional costs in particular if it comes to public construction projects, not only could project owners [clients], construction contractors but also community at large suffer from losses. Not only the contractor, but also the client’s role can be critical to the success of construction projects [13]. Clients do not pay on time or dispute claims for change orders or file for bankruptcy. Contractors cannot or do not reduce fixed overhead fast enough in rough times or their cash runs short. Sometimes, subcontractors do not perform as required, or go broke [14]. It is a common fact among the participants within the construction industry continually faced with a variety of situation, involving many unknown, unexpected, frequently undesirable and often unpredictable factors [15].
The most common and well-known risks embedded in construction are the health and safety issues, delivery scheduling and aspects related to finances. The sector is full of risks that relate to planning, execution, communication and interaction with the surrounding society [16]. A primary classification of construction industry risks are natural and human risks. Natural risks occur outside human agencies or systems, while human risks arise within humanly organized systems. The sub categories of human risks relating to construction and project risks include social, political, economic, financial, legal, health, managerial, technical and cultural risks [8].
Weather risks covers, adverse weather conditions, the probability of hurricane, typhoon, tornado, flood, tidal wave and lightning strike [8]. If it rains for 2 months while the job is coming out of the ground, meeting the schedules can be impossible [14]. Pollution is a risk factor, because dust, harmful gasses, noise, solid and all of the liquid wastes are harmful to nature and affect final quality of the construction [17].
Geological risks covers, discrepancy in geology and topographic conditions, the probability of earthquake, volcanic eruption and geotechnical fault [8]. Physical risks, such as subsurface conditions, are among the geological system risks of construction. Subsurface condition, different from anticipated, can lead to excavation costs, which is greater than expected [12]. Although, geological investigation reports provide information on the type of soil that contractors can expect to deal with, the contractor still has to rely on experience of the relative occurrences of ‘adverse ground conditions’ among different soil types, site conditions and site history to make judgments about the risk of adverse ground conditions on any site [18]. Site conditions, particularly subsurface conditions, can create an even greater degree of uncertainty for facilities with heretofore-unknown characteristics during operation [4]. Sometimes it can be possible that non-documented site conditions present themselves mid-project [14].
This type of human risks covers criminal acts, such as sabotage and arson, civil torts, such as trespass, damage to fences, unauthorized graffiti and similar acts of vandalism, and substance abuse. While such indices are likely to result in the project proponent appearing as plaintiff or as witnesses for the prosecution, these can also lead to risks of counterclaims by the perpetrators. Social risks in construction industry are becoming a more frequent occurrence on projects vulnerable to militant protest lobbies [8]. According to Chicken [19], social risks are one of the “soft” factors in risk management for major projects, largely because of the difficulty of dealing with them quantitatively.
War, civil disorder, industrial relations action are among the political risks of construction. This type of risks can arise from actions of the organization’s government against other countries, such as trade embargoes. Another probability of political risks can arise from action within the home country, such as statutory amendments made to industrial relations legislation after a change in government [8]. Disapproval of the required project permits one of the other political and public risks [12]. According to Chicken [19], political risks are the other “soft” factors in risk management for major projects. Political risks are also defined by Ashley and Bonner [20] as foreign government interference with the normal conduct of business, and written mainly in the context of multinational construction firms and developers operating in foreign countries [8].
This type of risks can occur due to unexpected changes in supplying materials and labor, availability of equipment, inflation, tariffs, fiscal policies and exchange rates. Cost escalation is another economic risk of construction [12]. Warszawski [21] considered inflation as a risk factor for cost control, profit planning and other managerial decision-making aspects of construction projects [8]. Economic conditions of the past decade have negative effect on the climate of uncertainty with high inflation and interest rates. The deregulation of financial institutions, related to the financing of construction, can cause unanticipated problems [4]. Inflation is an important risk factor, because the price of construction materials rises with inflation. Sometimes, inaccurate cost estimate, underestimation of construction costs due to lack of information [22], that when many unforeseen factors may occur in construction activities causing the estimated cost to deviate from the real cost is another risk factor. Long-term investment can be a risk factor, especially when the project delivery approach requires the contractor to make large endowments in advance [17].
This type of risks are about funding of the project and national and international impacts [23] can result unexpected changes in interest rates, credit ratings, capital supply, cash flows and rentals. Jaafari et al. [24] concluded at the end of their research that a prudent pre-construction risk evaluation of the project in real life would have revealed its financial feasibility [8]. Sometimes the cost certain materials spikes unexpectedly. Other times, suppliers can cut off credit [14]. Unavailability of funds, which means client’s poor management of funding in the development of construction projects, is another risk factor [17].
Risk allocation through the contractual aspect of building procurement covers contract clauses, regulations, code and changed labor’s safety laws or regulations. Legal risks, since the processes and remedies of subcontractor default, are widely found in the construction contract literature [8]. Contractual risks, such as risks assigned by contract over which the contractor has no control, are among the legal risks [12]. Amphibious contract, which means when the clauses of the contract are hard to understand because of the loose or awkward way in which they written, is an another important risk factor. Governmental bureaucracy, which means excessive approval procedures in government departments, is another source of risk [17]. Since inability to know what will be required and how long it will take to obtain approval from the regulatory agencies, the environmental protection movement has contributed to the uncertainty for construction. When the problems continue, after re-evaluation of the problems, additional costs can occur. Public safety regulations, which have been most noticeable in the energy field involving nuclear power plants and coal mining, have similar effects. As projects move through the stages of planning to construction, new dimension of uncertainty is added, can make it virtually impossible to schedule and complete work at budgeted cost [4].
A construction site is an environment vulnerable to viruses and infectious diseases. Health risks of construction are occurrence and impact of epidemic on construction projects [8]. Construction accidents resulting from operating errors or carelessness [22] and the occurrence of safety failures in construction forms an important health risk. When resulted with accidents, safety failures, may lead to surgeries, which is the other health risk category for construction projects.
Inefficiency of owner supervisors, productivity of labor, productivity of equipment and labor disputes [23] can lead to problems with the productivity on-site, quality assurance, cost control and human resource management. Labor availability and labor productivity, strikes and safety risks, such as worker injury or an injury to a member of the public, are the other managerial risks of construction [12]. Managerial strategies, which form managerial risks, can affect negatively or positively worker safety behavior and can make important contributions negatively or positively to occupational health and safety knowledge for construction [8]. Deregulation of safety, which means poor safety awareness of project managers and inaccurate safety measures, is an important risk factor. On the other hand, lack of insurance, in other words, if major equipment and employees are not insured, it is another risk factor. Design variations, which may result from issues such as changes by the client or defective designs is another source of risk. Communication is very important for the sake of project, and poor communication, lack of effective communication among project partners can lead important problems. Theft is a risk factor, because employees can steal construction materials and equipment [17]. Organizational relationships are the other source of risk, since strained relationships may develop between various organizations involved in the design/construction process. When the problems occur, although the focus should be on solving the problems, discussions often center on responsibilities rather than project that needs at a time [4].
Late drawing and instructions, defective design, availability of resources, suitability of materials, defective work [23] can result in design failure, equipment and systems failure, estimation error, collision and accident. Faulty design not detected by contractor in tendering process and contraction errors due to faulty design but not checked in time by contractor are among the other technical risks [22]. A project design that is not constructible, construction-related risks such as the inability of a subcontractor to perform, construction vehicle accidents are among the technical risks of construction [12]. Reworking or delay of work, poor workmanship of subcontractor and material overuse by subcontractor with poor technique or working habits are the other technical risks [22]. Lack of high-quality staff is a risk factor that poorly trained laborers may lead to poor quality outcomes for the project. Defective construction materials that do not meet the building requirements are another risk factor [17]. Site location, and access, equipment and system failure, new technology failure, and collisions and accidents are the other technical risks. The risk associated with the introduction of new technology is an important risk factor, particularly with regard to information technology and the building procurement process. Construction technical risks can also be tracked from the bidding phase to the estimating process, and thus, to the planning and scheduling of a project [8]. The machinery break down is one of the essential technical risks inherent in all types of construction projects. The maintenance program, equipment life and haul road condition are the three input factors influence the probability of machinery breakdown. Cost overrun and project delay are the major negative impacts on project objectives are the results of machinery breakdown risk [22].
This type of risks can occur when there are religion or/and cultural differences. Cultural issues can be relate to the risks of major international projects, but can also be found on home ground [8]. Liu et al. [25] intended to understand project risks as perceived by contractors from a perspective of culture how culture influences contractor’s risk management. According to their findings, project risks perceived and managed differently in different national cultures. Risks are extended when the host country cultures differs from a contractor’s expectation. International projects are inevitable that contractors could make effective plans to manage project risks, minimize the influences of cultural shock and develop a more realistic way of understanding and managing the differences. Where the host culture is similar to the contractor, risks are fewer and easier to manage than when the host culture is different [25].
The project success usually depends on the combination of all risks, although some of the individual risk factors may be more significant. Respond strategies used to mitigate risks and a company’s ability to manage them is fundamental [26]. Sound management of risk is a crucial determinant of the success of a project due to an increased attention to the variations in actual quality, time and cost performance compared to the expected ones, as a consequence of a growing pressure on reducing time and costs. Carborne and Tippett [27] demonstrated that failure to deal with risk is one main cause for exceeding budget, falling behind schedules and missing performance targets.
Risk is difficult and inherent to deal with, and this requires, both of theoretical and practical meanings a proper management framework [11]. It has demonstrated that failure to deal with risk is one main cause for missing performance targets, exceeding budget and falling behind schedules [27]. According to Guofeng et al. [28] in construction industry, this situation is exacerbated because, project is characterized by long execution processes, huge investments, many resources and stakeholders and unstable economic and political environments bring a high level of complexity [29]. In responding the risks and uncertainty, Ranasinghe [30] showed that the engineering construction industry should not allocate contingency at a predetermined probability of success for global variables such as project cost or duration, but rather at the input level. A suitable predetermined probability of success value to allocate contingency at the input level is about 70% and with at least 70% probability of success for bill items, work package costs and durations, or activity costs and durations, then contingency available for project cost and duration can ensure a high probability of success in successful completion of the project [30].
In the past, claims for damages were regularly presented subject to the precondition that an actual or rather obvious damage or loss at the structure occurred. However, in the meantime the claim increasingly asserted in the case of defects that have not yet led to damage or loss at the structures [31]. In building construction projects, probability of risks is difficult to assess, since each project has unique characteristics. Buildings are too dissimilar and it makes impossible to say what effect any one project will have on the firm providing it. It becomes easier to generalize about probabilities, when a series of building is repetitive [32]. The benefits of risk management are tremendous in construction projects. Risk management can improve the quality of cost estimate and decision-making, help projects completed on time and within budget, lower transaction costs and facilitate better risk allocation [33].
Risk management emphasized and implemented in construction projects, regardless of the project size to assure the achievement of project objectives; however, small projects are prone to more risks. Since, they face more challenges than large projects due to their innate characteristics such as resource constraints, tight project schedule, competition and low profit margin, small projects should managed diligently to prevent schedule and cost overruns. The benefits of risk management in small project and the impact of risk management on project performance are different from those in larger projects. Actually, risk management implementation in small projects would bring about benefits that outweigh the costs in the end [33].
Project complexity, the property of a project which makes it difficult to understand, foresee, and keep under control its overall behavior, even when given reasonably complete information about the project system [34], can contribute toward the failure of projects, in terms of cost and time overruns. Qazi et al. [35] consider the decision problem of identifying critical risks and selecting optimal risk mitigation strategies at the commencement stage of a project, taking into account the utility function of the decision-maker with regard to importance of project objectives and holistic interaction between project complexity and risk [35].
Construction is hazardous and the risk is significant, injury to individual workers and damage to property [14]. In any risk management program, insurance forms a major option to shift designated risks to a financially strong party, willing to assume some or all of the financial responsibility for the loss, for an agreed premium amount [2]. In construction industry, both the project owner and the contractor seek to control risk. One way project owners manage their risk requiring contractors to have certain types of insurance. Insurance protects contractors against certain events. Since, builder’s risk insurance protects the owner, the general contractor, the subcontractors and the material suppliers against fire, theft and wind, while the facility is under construction; it is an “all risk” policy [12].
An insurance policy is a contract between the two parties and spells out obligations, responsibilities, benefits available and policy exclusions [14]. Purchasing insurance, to cover specific events that would result in a loss if they occur, is the primary way to manage risks. When a key piece of equipment is lost and can cause the contractor additional unplanned costs, insurance can cover the loss. If a contractor who owns and operates only one bulldozer, the loss of the bulldozer would be a risk that would put the contractor out of business. Insuring the bulldozer is a way for the contractor to manage that risk [12].
Odeyinka [36] identified the sources of insurable construction risks perceived to encounter in the Nigerian construction industry, and the types of insurance policy employed in managing them, examined how they managed through insurance premiums and investigated the effectiveness of the use of insurance. If there is any damage to the work, the risk bearing responsibility transferred to the insurance company by the contractor. The results of his study showed that great importance placed on-site security, construction risks, and health and welfare requirements, and the use of an all-risk insurance policy is the most prominent method for managing the identified risks. He found a correlation between insured sum and actual replacement cost when there are losses or damages. All-risk policies cover all the risks in construction except those specified by exclusion clauses. Odeyinka [36] concluded that actual replacement cost had a significant relationship with the claim settled. He concluded also that there was a significant correlation between the actual cost of replacement and the claim settled and the use of insurance was effective in managing construction risks [36].
Song et al. [37] investigated the possibility of using insurance for alternative dispute-resolution implementation and then subjective loss to represent the risk-averse attitude of project participants and quantify the effect of alternative dispute-resolution implementation costs in monetary terms. One approach to reduce the negative influence of uncertain alternative dispute-resolution implementation costs is to structure and price potential financial consequences of the cost losses as an insurance product. Thus, it becomes possible to transfer the risk of unexpectedly high alternative dispute-resolution costs from the project participant to insurance company. The insurance company receives a premium that covers the company’s underwriting expenses and targeted profit, in return. However, the risk transfer process does not directly eliminate the possibility that a dispute will occur. Compared to the uneven occurrence of alternative dispute-resolution implementation costs in the traditional self-funded model, periodic payout of premiums helps maintain a stable cash flow and thus makes it easier to budget and plan for insurance expenditures. The risk transfer process reimburses any alternative dispute-resolution implementation costs associated with that dispute [37].
There are a number of the more common and usual types of insurance, of the general interest to owners, contractors, subcontractors, construction managers and design professionals.
This type of insurance designed to provide the statutory benefits required by state law to an employee hurt or killed because of employment [2]. This type of insurance protects workers, injured on the job, covering medical and hospitalization expenses, plus a percentage of the hourly wage during the time the employee out of work. The worker’s compensation insurance protects contractor by limiting the workers’ remedy from the employer to the amount that covered by the worker’s compensation law [12]. Employers required by law, maintain statutory worker’s compensation insurance for their employees, and in exchange relieve of direct liability for an injured worker’s claims [14].
They are the contractor safety programs that form another example of risk management. If the contraction company has a high accident rate, the company will have a high experience modifier rating. A high experience modifier rating increases the cost of worker’s compensation insurance and therefore makes the contractors less competitive. A good contractor works very hard at reducing the occurrence and severity of accidents [12].
This type of insurance protects against third-party liability claims for property damage or personal injury that arise from the contractors’ operations and acts, and the operations of subcontractors or representatives and tailored to protect against other claims [14]. The basic policy endorsed to include coverage for contractor’s and owner’s protective insurance, products and completed operations, personal injury (libel, slander, etc.) blanket contractual and coverage for liability arising from the insured’s automobiles. This type of insurance is against liability imposed by law for negligent acts occurring in the conduct of the business, which result in bodily injury or damage to the property of others [2].
When the contractor assumes the legal liability of the owner, designer or other designated party,
This type of insurance protects architects and engineers from liability based upon professional errors or omissions in performing design, construction management or other services [2].
The aim of this type of insurance is providing protection to the insured party or parties against physical damage. Destruction of the project or temporary buildings on the job site by external causes such as fire and storm, and the insurance should include not only physical damages, but also coverage for materials stored in transit to job site waiting for incorporation into the project [14]. Builder’s risk insurance is against the cost of damage of a physical nature to a building or other component of a construction project. This type of insurance covers material and equipment not yet incorporated into the work when located on site or in transit to the site. Generally it include the interests of the owner, the general contractor and material supplies [2].
They protect damages to mobile and stationary construction equipment, which is not generally subject to vehicle registration. It is coverage for damage to the equipment whether located at the job site, in transit, or at the contractor’s yard, but not liability and property damage insurance for cars, trucks and other equipment subject to the motor vehicle licensing laws, since they covered under other liability policies [2].
This type of insurance is established by the owners to cover the owner, contractors, subcontractors, construction managers and the designers. Basic policies generally cover comprehensive general liability insurance, excess general liability, builder’s risk, worker’s compensation and occasionally errors and omissions insurance. Equipment floaters, and the deductible or self-insured retention and automobile liability insurance normally continue to be the responsibility of the individual injured [2].
A surety is a company that guaranties for a fee the obligations of one party to another party. When the surety, usually an insurance company, guaranties to a project owner that his contractor will perform as required by the construction contract between the owner and the contractor, this is a bond made in writing. The surety is obliged to the owner to see that the contract completed—up to the face amount of the bond, if the contractor defaults on his obligations under the construction contract [14]. Surety bonding is an effective risk mitigation approach to avoid the possible risk of contractor default, in the construction industry. The surety company carries the risk of contractor pre-qualification and quarantines the project completion according to the contractual obligations, when a surety company agrees to bond a contractor for a construction project. The surety company, through a surety underwriter, conducts an evaluation of the contractor to estimate contractor competency for performing a specific project [38].
A construction owner is under the risk that the general contractor will not be able to complete the project on schedule, within budget, and in compliance with plans and specifications. It is the same for the general contractor; similarly, a general contractor runs the same risk against subcontractors. A surety bond is a financial instrument used to guarantee the completion of an obligation. The oblige turn to the bonding company, step in and, on behalf of the principal, accomplish the work according to contract terms, if the principal fails to perform [39].
Kangari and Bakheed [40] identified and classified quantitative and qualitative risk factors that impact construction bond underwriting, to improve the quality of the evaluation analysis and to reduce the highly unstructured environment and the subjectivity of the bond evaluation in underwriting. The objective of their paper was, based on a set of surveys and interviews with surety companies, to identify major factors impact surety-bond evaluation. The results showed that, contractor’s financial strength was the first important factor. The second one was contractors past experience or character attributes such as the quality of contractor’s people and their experience, contractors past work, contractor’s business plan and trust with agents. Contractor’s capacity, work schedule to analyze job’s consistency and potential project characteristics; and contractor’s continuity that came as the least important factor among the others [40].
There are three types of common and usual construction surety bonds of the general interest to owners, contractors and subcontractors.
Construction surety bonds, for the performance of construction contract obligations that provide a third-party guarantee. Performance bonds are one of them that guarantee performance of contract obligations to the owner as set forth in the contract, but it is not insurance. The amount of the performance bond guaranteed to make available by the surety to complete the contract in the event of default by the contractor, which represents total contract price. The surety is obligated either complete the work or to arrange with the owner to pay for the cost of completion of the work less, in the event of default [2].
They provide guarantee for the contractor’s surety that the contractor contracts and provides required bonding if selected. If the bid or proposal is successful, surety remuneration comes from furnishing the performance and payment bonds and the contractor normally does not pay any premium for bid bonds [2].
They provide prompt payment to all those furnishing labor and/or materials to the job. Although payment is made to the subcontractor by the general contractor, this type of clause cover unpaid bills to the same subcontractor [2]. This assures the owner that the vendors do not cause to place liens on his property [14].
In some circumstances, utilizing a combination payment and performance bond, under the amount of total contract price, can be preferred [2].
In the construction business, contracts are the vehicles used for the procurement of everything, both services and goods. A contract is an agreement between two parties that is enforceable by law, and protects parties such as contractors against risks. When the site subsurface conditions might not be exactly what the contractor anticipated or any changes in conditions occur, examining the contract language addressing these changes makes possible to protect against risks [12]. Successful project execution requires a proper contractual foundation and construction contracts have a key role with fair, clear and comprehensive allocation of risks [23]. Construction contract risks are qualitative, based on analyst’s knowledge and experience of the risks and the process by which the analyst selects and organizes such knowledge and experiences into meaningful patterns [41]. Contracts for today’s extended and interconnected enterprise have growing importance. Contracts are management tools in terms of risk, opportunities for value creation, successful inter-firm collaboration, profitability and competitive advantage. Contracts can help enabling companies to share, minimize and manage risks; preventing problems; and keeping problems from developing into disputes. In a situation where a dispute is unavoidable, contracts provide evidence of what agreed and an effective means to control and resolve dispute [42]. Many countries have develop standardized conditions contract to be used in construction projects. All contracts based on the general conditions of contract that formalize risk allocation in Sweden. They assign liabilities and responsibilities of each contracting party regarding job performance, organization, timeframes, guaranties, insurances, errors and payments [43].
Misunderstandings, delays, claims or disputes can be unexpected losses or other negative outcomes of contracts. Including goodwill and reputation a lot is at stake and contract disputes are expensive. If contracts fail, business performance will suffer, in terms of money, management and staff time that used for productive work. Language risks and contract wording is one of the sources of contract risk. The parties seldom concur on the terms of agreement, what those terms mean, when a dispute arises. Perceptions, growing complexity and communication failures are the other sources of contract risks and help to understand the true causes of contract risk. Contracts are a record of what agreed and communicate the deal and its terms clearly, so that future disputes over their meaning avoided. Gaps in the contracting process or lack of contract management are the next contractual risk. When several organizations and supply chain are added, the process becomes more complex and delivering the promises made in documents is not easy [42].
According to Rahman and Kumaraswamy [44], appropriate, clear and equitable conditions of contract are invaluable for successful projects. Appropriate contract conditions are important to meet the specific requirements and objectives of the project. Contract conditions should be clear to define the rights and duties of project participants and unequivocally allocate risks or future uncertainties to the different contracting parties. Contract conditions also expected to be equitable, apart from merely following the often-espoused principle of assigning the risks to those best equipped to deal with them [44].
Since any construction project involves risk, eliminating all the risks associated with a specific project is impossible. Regulating the risk allocated to different parties and then properly managing the risk is all that done. The language of the construction contract can achieve this. Serving as a framework between the parties to establish which one has assumed which risk is one of the objectives of the contract. Risk sharing or risk shifting decisions made within the context of the contracting policy an owner [45]. Construction contracts not only serve as a means of pricing construction, they also structure the allocation of risk to the various parties involved.
In a
Since the owners interested in knowing which risk factors will generate significant impacts on the projects, the identification of risks is a significant test for all major contracting parties across all building and civil engineering projects [47]. Risk allocation is the definition and division of responsibility associated with a possible future loss or gain and its objective is seeking to assign responsibility for a variety of hypothetical circumstances, if the project does not proceed as planned. Risk allocation is a part of risk management strategy, through the contractual documents. The owner generally has a tendency to pass the responsibility for most of the risks to the contractor contractually, under traditional procurement processes. A contract indicates willingness of the contractor for undertaking the work and his accepting both the controllable and uncontrollable risks. The principles behind the allocation in the documents of model or standard sets of general conditions have not clearly stated, although model or standard sets of general conditions of contract are available. Any problems can occur using any of the model or standard sets of general conditions of contract, if additional clauses affecting risk applied to them. Moreover, in today’s high-risk scenarios and multiparty complex projects, the nature and extend of risks tend to be project specific that adoption of tailor-made contract strategies is more desirable [48]. According to Zaghloul and Hartman [45], with the absence of trust in business relationships, the success of any project or business relationship is always questionable. Their findings identify the relationship between trust and risk allocation practices in construction contracts. How a strong relationship can reduce the final cost of any specific project by improving the risk allocation method between the contracting parties [45].
The aim of the Chang’s [46] study is to make a case for the need of incorporating the consequence of contract breakup into risk allocation decisions, and analyzed the modeling of the post-contract hazard. A compelling reason for taking this factor seriously is that contract breakup may result in contracting parties incurring substantial additional costs. Although owners have a larger stake and hence have a stronger incentive to stay in the project; contractors’ staying in or leaving the project depend on their risk bearing capacity. Beginning with an analyzation of standard pain-gain sharing arrangement in construction contracts, Chang [46] found that taking no account of contract breakup hazards result in underuse of incentives. When the outturn cost also depends on the contractor’s effort high-powered incentives offered to the contractor when cost variations expected to be modest, contractor’s distaste for risk taking is low, and contractor’s disutility does not rise steeply. According to Chang [46], contract breakup potential is an important factor and incentives more intensively used to harness the contractor’s potential in cost reduction because the efficiency savings stimulated by stronger incentives can serve as a buffer for downside risks and thus reduce the expected loss of contract breakup [46].
Contract choice decisions are central to the management of risk and uncertainty. Chapman and Ward [49] indicated that the starting position has to be a best practice approach to risk management in terms of the whole project life cycle. Fully integrating a balanced incentive and risk sharing approach to contracting is of central concern for a successful risk management. A two-dimensional view of risk and uncertainty, a linked risk efficiency view of choices and addressing both expected outcomes and potential departures from expectations, is essential for this integration to work. A concern for all sources of uncertainty, including ambiguity and lack of knowledge and addressing dependence and feedback is essential for an effective contract choice decision. Clients need to choose an appropriate form of contract from available common options and facilitating appropriate choices usefully addressed within a balanced incentive and risk sharing contract framework. According to Chapman and Ward [49], comparative measurement and related comparative assessment of assumptions is the key to effective choices. They indicated that the key overall conclusion is that full integration of contract choice decisions with a best practice approach to risk management is both practical and advantageous [49].
Subcontracting is outsourcing a part of the job to another group and it is widely used in construction. Demand volatility, high level of risk and uncertainty are some special conditions of construction industry that causes subcontracting and enables some advantages to general contractor, even if the size of the firm and capacity of work increase. The construction industry traditionally uses the method of subcontracting to fulfill the need for flexibility and short-term project objectives. According to Eccless [5], since bounded rationality of the general contractor in highly uncertain conditions, market contracting is preferred over vertical integration [6]. Subcontracting is another form of risk management. There is a great risk for a company performing in construction industry; a contractor can reduce project risk by hiring qualified subcontractors. The cost may be increased, but an unqualified subcontractor is a greater risk. The return justifies the cost by reducing the constructor’s exposure to risk [12].
Unstable market conditions are the overriding reason for general contractors to conduct transactions with subcontractors, since subcontracting out work packages enables general contractors to be flexible in responding to potential market difficulties. The construction industry hosts an unstable and seasonal demand [i.e. market volatility] because construction firms to split into autonomous units and to rely on subcontractors to undertake some of the work packages. As construction firms prefer being flexible, general contractor-subcontractor relationship emerges as a rational response to the instability of demand in construction markets and to problems caused by seasonality. Uncertainty and asset specificity are the two dimensions of general contractor-subcontractor transactions. Uncertainty in general contractor-subcontractor transactions can both stem from the nature of the construction process and from the potential partner’s performance during the course of the construction process. One of the sources causing uncertainty in the construction process is that construction operations carried out on sites, which present uncertainties regarding weather and soil conditions. Each project requires a new design and generates new production problems regarding the coordination and integration of the outputs of specialized task groups which carry out interdependent tasks; and the contracting system itself is a recipe for uncertainty since cost estimation is not an exact science are the other ones. General contractors and subcontractors also face difficulties in assessing each other’s performance, which means poor performance on the part of either party, can have profound effects on the other one [50].
Subcontracting is widely used much more extensively on housing and building construction projects than on engineering projects and industrial projects. Regardless of the general contractor’s skills, especially building projects, it is common for subcontractors [39] perform 80–90% of the work. In spite of the benefits of subcontracting, there are some inherent risks. Quality is a critical issue and the cost of quality rectification problems is high. The contractor enters into contractual arrangements with the subcontractors in the traditional procurement arrangement option. Coordinating and controlling the works to ensure that the project delivered to time, cost and quality targets are the responsibilities of contractor. It is more risky when the main contractor in managing subcontractors, especially where the value of the subcontractors’ work is significant in relation to the main contractor’s work. The main contractor’s performance and reputation may depend on the performance of the subcontractors. The control and coordination of the subcontractors and their works become problematic, and could result in unsatisfactory project outcomes. In this context, the main contractor becomes a construction manager and need to have sufficient construction management skills [51].
General contractor-subcontractor transactions involve a ‘high human asset specific investment’ and high human asset specificity is a direct result of the production technology used in the construction process. Interdependence among work groups is high, and its predecessors in the construction process define the workplace of a group. General contractors and subcontractors restrict access to transaction relationships increases the frequency of transactions between existing parties and enables them to learn from one another to overcome problems caused by newness. Learning new roles, coordination problems, developing trust and communication routes are some of these problems [50]. While main contractors do not depend on subcontracting alone, they support construction activities with their own resources, including equipment and labor. When the main contractors use their own resources, main contractors’ control of the overall quality of construction is vastly improved. The control will be more affective, when the employment is direct. Contractors may get a better quality job, by having direct control on work. There is a looser relationship between employer and employee in subcontracting, and the client and main contractor have very little control over who carries out the specialist work under a subcontract [52].
Subcontracting is another way of managing risks; however, arbitrary passing down risk can create problems, relating to unequal risk allocation. Sometimes, risks not allocated to the party in the best position to manage them. People have less decision power toward the end of the construction supply chain. Increased subcontracting enables the re-distribution of risks between a numbers of subcontractors. In this process, rather than formal quantification and evaluation, perceptions of risk play an important role in determining the allocation of risk between contractual parties [53].
Mbachu [54] analyzed the various ways in which the subcontractor could contribute to the contractor’s payment risks and cash flow problems. The results showed that cost management and subcontractor project implementation were the two broad classifications of risk sources. The key issues related to a lack of risk management and administration skills were the results of the evaluation of the various risk factors attributed to the subcontractor have cost management issues. Poor productivity, poor documentation and taking too many jobs at the same time were the three subsets of risk factors under the subcontractor’s project implementation role. The major solution overcoming these problems was that using head contractor his/her key skills in risk management, administration and coordination to assist the subcontractor in overcoming these problems [54].
Risk commonly transferred to the subcontractor in the construction industry. According to Arditi and Chotibhongs [39], broad form indemnity, which entirely relieves the general contractor and/or owner from covering losses related to the subcontractor’s performance of work, regardless of the cause or type of risk is the least balanced approach for a subcontractor. The additional insured endorsement is another risk, which is independent, but can have the same effect. The owner and/or general contractor named as insured under the subcontractor’s commercial general liability policy. The waiver of subrogation is a third method of risk transfer that makes the subcontractor responsible for losses controlled by other parties. Signing a waiver, asked by the general contractor and/or owner, protects the subcontractor’s insurance carrier from making any claim to recover funds from the general contractor that the carrier paid out to cover a loss [39].
The construction industry has a dynamic, challenging and high risky business environment. Since the characteristics of the industry is specific and resources used for the production are diverse and at a high rate, the process directly related with sustainability. Sustainable development movement has evolved worldwide for almost two decades and caused significant changes in construction delivery systems. Since sustainable development requires an affective and carefully consuming the resources of the earth, an effective risk management is a key for achieving sustainability in construction projects, in particular building projects, not only to secure work, but also to make profit. In construction industry, uncertainty contributes to most of the problems related to contractual, client and commercial issues. Construction projects are prone to more risk and uncertainty than any other industries, such as production or service industries. Sometimes lack of close collaboration among the stakeholders can enough to lead higher levels of risk for success of the project. A collection of different risk factors occurs for risk management consideration by the Construction Company or contractor. Uncertainty may lead to changes in the performance of the task relating to productivity, work method, supply and quality of labor and materials can affect the construction projects’ time and/or cost. It is possible that sometimes uncertainty can lead to the inflated prizing or the deflated pricing in the tendering phase. There are different tools to manage risks of construction. A construction company with a well-prepared contract can overcome the difficulties of uncertainty and achieve low cost by optimizing the cost effectiveness of risk allocation. Construction insurance, surety bonds and subcontracting are the other main affective solutions for the risk management in building construction projects.
Members of the class
Membership of the mycolic acid-containing actinobacterial (MACA) group has expanded considerably over the past 20 years with revisions to the classification of existing species and the publication of copious new mycolate species and genera [2]. This substantial and metabolically diverse group therefore warrants further attention in the search for valuable biosurfactants. This chapter provides an overview of the current knowledge on biosurfactants produced by members of this group and describes approaches to the recovery, screening and biosurfactant-producing strains from the environment and their growth requirements. Methodologies applied to screen for biosurfactant production and for extraction, purification, and structural elucidation of biosurfactant compounds are also described. Current and potential future applications of biosurfactants derived from MACA are examined with particular focus on potential biomedical and environmental possibilities.
Microbial biosurfactants are amphipathic compounds, with both hydrophilic (polar) and hydrophobic (non-polar) moieties. The hydrophobic portion has saturated, unsaturated, or hydroxylated long-chain fatty acids and the hydrophilic portion can contain amino acids, carbohydrate, carboxyl acid, peptides, phosphate, or alcohol [3]. Biosurfactants may be categorised according to molecular weight (low or high), ionic charge (anionic, cationic, neutral, or non-ionic) or according to chemical composition and structure. The main classes of biosurfactants include fatty acids, glycolipids, lipopeptides, lipoproteins, neutral lipids, phospholipids, and polymeric biosurfactants. Their amphipathic nature enables biosurfactants to partition at water-air, oil-air, or oil-water interfaces thereby reducing surface and/or interfacial tension. They exhibit many other useful properties including de-/emulsification, dispersion, foaming, lubrication, softening, stabilisation, viscosity reduction and wetting [4].
Biosurfactants may be located intracellularly, on the cell surface (cell-bound) or excreted extracellularly (free) [5] and are produced during growth on both hydrophilic and hydrophobic substrates, to reduce surface or interfacial properties of the microbial cell or the surrounding environment. Biosynthesis of these compounds is required for gliding, motility, swarming, and biofilm formation. Biosurfactants also mediate between cells and hydrophobic compounds, enabling enhanced solubilisation and uptake across the cell membrane for utilisation as a substrate for growth and energy (Figure 1).
Emulsification of hydrocarbons by microbial biosurfactants to enhance bioavailability.
Many microbially derived biosurfactants are already used in diverse industries including agriculture, bioremediation, cosmetics, food, healthcare and medicine, and the petrochemical industry (Figure 2). In addition to being multifunctional, biosurfactants have several advantages over chemically synthesised surfactants. They are less/non-toxic and biodegradable, have higher surface activity and lower critical micelle concentrations (CMC), greater biocompatibility and selectivity, they function over wide pH, salinity, and temperature ranges, and can be produced using renewable and waste substrates [6]. These unique eco-friendly features make biosurfactants particularly attractive options as industries focus on longer-term sustainability and working towards a circular economy.
Various sectors of application for microbial biosurfactants.
The MACA form a phylogenetically coherent group that resides in the order
Mycolic acids, which are high molecular weight 3-hydroxy fatty acids with a long alkyl branch in the 2-position, represent the major lipid constituents of the cell envelope of these organisms. They show structural variations from relatively simple mixtures of saturated and unsaturated compounds in corynebacteria to highly complex mixtures in mycobacteria. Mycolic acids also vary in the number of carbons on the 2-alkyl-branch from C22–C38 in corynebacteria to C60–C90 in mycobacteria [9]. Mycolic acids play an essential role in the architecture and functions of the cell envelope, where attached to the cell wall arabinogalactan they help to form a barrier that contributes to impermeability and resilience and conveys hydrophobicity to the cell surface. Trehalose mycolates, also termed cord factors, play an important role in pathogenicity in mycobacterial species that cause infection [9]. The presence and carbon chain length of mycolic acids can be used as taxonomic markers for the identification and classification of actinobacteria to the order
Members of order
Genus | Micro-morphology | Acid-fastness | Aerial hyphae | Visible colonies (days) | Strictly aerobic |
---|---|---|---|---|---|
Pleomorphic rods, often club-shaped in palisade or angular arrangements | Some weakly acid-fast | Absent | 1–2 | No | |
Short rods and cocci | No | Absent | 1–3 | Yes | |
Rods, cocci and/or moderately branching hyphae | Partially acid-alcohol fast | Absent | 1–3 | Yes | |
Cocci occur singly, in pairs, tetrads or in groups | Slightly acid–alcohol-fast | Absent | 2 | Yes | |
Pleomorphic bacilli and cocci | Partially acid-fast | Absent | 5–7 | No | |
Short rods | Acid-alcohol fast | Absent | 1–3 | Yes | |
Rods, occasionally branched filaments that fragment to rods and cocci | Strongly acid-fast | Rare | 2–40 | Yes | |
Mycelia that fragment into rods and cocci | Partially acid-fast | Present | 1–5 | Yes | |
Rods to extensive substrate mycelia that fragment to irregular rods and cocci | Partially acid-fast | Absent | 1–3 | Yes | |
Rods | Acid-alcohol fast | Absent | 3–4 | Yes | |
Acute angled branched mycelia | No | Only visible under the microscope | 10–21 | No | |
Coccoid | ND | Absent | 7–14 | Yes | |
Irregular rods | ND | Absent | ND | Yes | |
Single rods or in pairs or masses, sometimes rudimentary filaments and coccobacillary forms | Partially alcohol-acid fast | Absent | 1–3 | Yes | |
Thin rods or cocci in pairs or clusters | ND | Present | 1–4 | Yes |
General phenotypic features of mycolate genera classified in the order
ND, not determined.
Adapted from [2].
The appearance of (a)
Chemotaxonomy is the study of the distribution of various cell wall components to classify and identify strains and is particularly useful to differentiate between the various mycolic acid-containing genera. Cell wall markers typically used to differentiate between MACA genera are summarised in Table 2. Some of the methods used to analyse these chemotaxonomic markers provide quantitative or semi-quantitative data, as in the case of fatty acids, whereas other techniques provide only qualitative data as in the case of muramic acid type and phospholipid pattern.
Genus | Mycolic acids (chain length) | Fatty acids* | Phospholipid type | Major menaquinone(s) | Muramic acid type | gDNA G + C (mol%) |
---|---|---|---|---|---|---|
22–38 | S,U | I | MK-8(H2) | Acetylated | 51–67 | |
34–38 | S,U,T | II | MK-8(H2) | Acetylated | 65.5–73 | |
46–66 | S,U,T | II | MK-9(H2) | Glycolated | 63–69 | |
30–38 | II | MK-8 | Acetylated | 49.3–61.8 | ||
α+-mycolate | S,U | I | MK-9 | Acetylated | 58.6 | |
44–52 | S,U, T | II | MK-8(H2) | Glycolated | 64.7 | |
60–90 | S,U,T | II | MK-9(H2) | Glycolated | 57–73 | |
48–60 | S,U,T | II | MK-8(H4, Ѡ-cycl) | Glycolated | 63–72 | |
30–54 | S,U,T | II | MK-8(H2) | Glycolated | 63–73 | |
α+-mycolate | T | 68–72 | ||||
58–64 | S,U,T | II | MK-8(H4, Ѡ-cycl) | Glycolated | 67.5 | |
43–49 | S,U | II | SQA-8(H4, Ѡ-cycl) SQB(H4, dicycl) | Glycolated | 63.7 | |
42–52 | S,U | II | MK-9(H2) | Glycolated | 67.5–71.6 | |
64–78 | S,U,T | II | MK-9 | Glycolated | 67–78 | |
50–56 | S,U,T | II | MK-9(H2) | Glycolated | 64–65 |
Chemotaxonomic features of mycolate genera classified in the order
S, straight-chain saturated fatty acids; U, straight-chain unsaturated fatty acids; T, tuberculostearic acid.
Adapted from [2].
Reliable identification of MACA strains to species level depends upon phylogenetic analysis of the gene encoding 16S rRNA and DNA:DNA homology determination provides definitive delineation of species with 70% homology and above signifying membership of same species [11]. Increasingly, whole-genome sequencing (WGS) is becoming a standard technique and comparative genomic analysis is providing useful insights to the relatedness and divergence of MACA species [11]. Protein sequences from
In addition to
Types and key structural features of various biosurfactants produced by MACA. (Adapted from [
MACA are widely distributed in the environment including natural habitats such as mangroves, soil, freshwater, and deep ocean sediments as well as man-made sites such as activated sludge foams, biofilters, industrial wastewater and indoor building materials. Although predominantly saprophytic, many species are opportunistic pathogens forming parasitic associations with plants and animals, including humans, notably immunocompromised individuals. Several members of the genus
MACA capable of producing various biosurfactants have been isolated from environments (Table 3) including oil-contaminated soils [24, 25], water from oil wells [26], wastewater from the rubber industry [21], activated sludge, and effluent and sediment from pesticide manufacturing facilities [23]. The ability of MACA to produce biosurfactants in these habitats appears to be driven by the environmental conditions to which they are exposed whereby the biosurfactants act as mediators for the biodegradation of hydrophobic carbon substrates. Genes involved in biosynthesis of rhamnolipids by
MACA species | Source of isolation | Biosurfactant type | References |
---|---|---|---|
Deep-sea hydrothermal field | Di-rhamnolipid (DRL) | [15] | |
Water and sediments collected from oil-polluted seasonal ponds | Methylated ester | [16] | |
Oil contaminated seawater | Rhamnolipid | [17] | |
Activated sludge foam | THL | [18] | |
HS-11 | Oil contaminated soil | Glycolipid | [19] |
Agricultural soil | Glycolipid | [20] | |
Water polluted by rejections of 2-mercaptobenzothiazole and its derivatives used in the rubber industry | Fatty acid methyl esters | [21] | |
Fell field soil | Rhamnose-containing glycolipid | [22] | |
Effluent-sediment collected from a pesticide manufacturing facility | THLs | [23] |
Various environmental sources of biosurfactant-producing MACA.
Isolation of biosurfactant producers largely relies on selective isolation strategies, utilising hydrophobic compounds as sole carbon sources for energy and growth. Typically, strains are isolated and cultivated using mineral salt medium containing essential trace elements supplemented with a hydrocarbon substrate such as crude oil, diesel, n-alkanes, n-hexadecane, paraffin, polyaromatic hydrocarbons (PAHs), or vegetable oils such as olive oil and rapeseed oil, as the sole carbon source. These may be incorporated into the liquid or solid medium, spread across the agar surface or soaked onto a filter in the lid of petri dishes. Besides the selectivity of the culture medium, pre-enrichment techniques utilising hydrophobic compounds as the sole carbon source, can be used [27]. The principle of enrichment is to provide growth conditions that are favourable for the organisms of interest but not for competing organisms. This selective advantage allows target populations to expand through a series of passages, maximising the chances of successful recovery at the isolation stage. Incorporating antibiotics into the isolation media may provide a useful additional selective pressure to eliminate or reduce unwanted fungi and bacteria.
The ability of an organism to grow on hydrophobic compounds is a good indicator of biosurfactant production but is not a guarantee. It is therefore important that isolates of interest are tested in pure culture for biosurfactant production using further screening assays. It is also possible that biosurfactant-producing organisms may be present in an environment but not enriched by in the conditions provided or indeed producers may be recovered from the environment but not synthesize biosurfactants under the culture conditions imposed. Mining genomes for cryptic biosurfactant biosynthesis pathways, and metagenomic screening of DNA from environmental samples promise an alternative approach to biosurfactant discovery that may circumvent some of the issues associated with culture-dependent strategies [28].
A variety of methods, both qualitative and quantitative, have been applied to screen microbial cultures and cell-free media for total (intracellular, surface-bound, and freely released) and freely released biosurfactants, respectively. As biosurfactants are structurally diverse, complex molecules, most of these methods are indirect, reliant on physico-chemical properties such as emulsification, surface activity or hydrophobicity. Commonly reported screening methods used to detect biosurfactant production amongst MACA strains are listed in Table 4. Besides the bacterial adhesion to hydrocarbons (BATH) assay [37] other tests based on cell surface hydrophobicity include salt aggregation [38] and hydrocarbon overlay [39] assays. The atomized oil assay [40] may be used to directly screen colonies growing on primary isolation plates and is therefore useful as an initial screen for novel-producing strains recovered from the environment. The microplate assay [41] which relies on the wetting properties of biosurfactants and the penetration assay [42], which relies on the reduction of interfacial tension are also considered useful for screening large numbers of strains. Recently, a rapid, high throughput assay that utilises Victoria pure blue BO dye, and is based on surface-active properties, has been developed for quantitative screening, but has not yet been applied to MACA [43].
Detection property | Screening method | MACA species | Reference |
---|---|---|---|
Surface activity | Oil spreading | [29] | |
[30] | |||
[31] | |||
Drop collapse/ modified drop collapse | [20] | ||
[29] | |||
Surface and interfacial tension measurement | [14, 26, 29] | ||
[20, 30, 32] | |||
[18] | |||
[31, 33] | |||
[17] | |||
Emulsification | Emulsification assay | [34] | |
Emulsification index | [14, 22, 35] | ||
[30, 32] | |||
[18] | |||
[31, 33] | |||
[17] | |||
Cell-surface hydrophobicity | Microbial adhesion to hydrocarbons (MATH)/BATH assay | [22] | |
[36] | |||
[33] | |||
[17] |
Examples of screening methods used to detect biosurfactant production by MACA.
These assays are simpler and more rapid than chemical analytical procedures, and most enable larger-scale screening for biosurfactant production. However, perhaps owing to the general and indirect nature of these assays and various limitations associated with some, test results between assays are not always congruent and no one assay is considered definitive for biosurfactant production. It is thus advisable to use several methods in combination, adopting simple methods to undertake preliminary screening of large strains collections prior to further investigation of those found to be most promising. The development of high-throughput screening, metabolic profiling technologies, and whole-genome analysis promise a more thorough investigation of potential biosurfactant producing strain in the future [28].
Crude biosurfactant extracts may be obtained from cell cultures (cell-associated and free surfactants) or cell-free broth (free surfactant only) by acidification and solidification followed by solvent extraction of the precipitate. In the case of MACA commonly used solvents include MTBE, dichloromethane, or varying ratios of chloroform–methanol or MTBE–chloroform [44]. Various analytical techniques are used in combination to detect, quantify, and characterise biosurfactants. Thin layer chromatography (TLC) is a straightforward method to separate biosurfactant fractions present in crude extracts. Samples are spotted at the base of a silica plate before development in a solvent system, then air-dried and sprayed with a particular reagent to detect certain chemical groups based on spot colour and/or
High-performance liquid chromatography-mass spectrometry (HPLC-MS) allows more precise and accurate characterisation and quantitation of biosurfactant compounds. Isocratic HPLC-UV has been reported for structural and yield determination of THLs produced by
A combination of Fourier transform infrared spectroscopy (FTIR), NMR, and liquid chromatography-mass spectrometry (LC-MS) enabled structural characterisation of a novel cyclic lipopeptide, Coryxin, produced by
Biosurfactants produced by rhodococci and related MACA have been investigated primarily for their potential application in oil remediation but are otherwise under-studied and under-exploited. However, research studies reveal various potential applications for these molecules, including in environmental and medical fields as summarised in Figure 5.
Promising medical and environmental applications for biosurfactants produced by MACA.
Biosurfactants produced by microorganisms are reported to have various potential biomedical and pharmaceutical applications which have been reviewed widely [1, 51, 52]. This stems from an array of biological properties including anti-adhesion and antibiofilm, anti-inflammatory, antimicrobial (anti-bacterial, anti-fungal and anti-viral), antioxidant, anti-tumour, and wound healing activities. Other potential applications include adjuvants for antigens in vaccines, pulmonary surfactants, drug delivery systems, enhanced vehicles for gene therapy and in dermatological care. Biosurfactants also have several applications in therapeutic dentistry [53]. Daptomycin, a cyclic lipopeptide produced by the actinobacterium
Strain (origin) | Biosurfactant | Biomedical properties | Reference |
---|---|---|---|
Purified Coryxin (lipopeptide) | Antibacterial activity, biofilm inhibition and disruption of pre-formed biofilms of Gram-positive | [48] | |
Aliphatic macrolide (Brasilinolide) | Moderately antifungal against | [56] | |
THL | Anti-tumour activity: cytotoxic effects on human tumour cell lines BV-173 and SKW-3, and to a lesser extent, HL-60. Mediated cell death by the induction of partial apoptotic DNA laddering | [57] | |
Complex of amino lipids; neutral lipids (mycolic and | Anti-adhesive activity against Gram-negative bacteria | [58] | |
Purified STL-1 | [59, 60] | ||
Complex of trehalose mono- and di-mycolates; neutral lipids (cetyl alcohol, palmitic acid, methyl ether of | Antibacterial activity against Gram-positive bacteria | [58] | |
Anti-adhesive activity against Gram-negative bacteria and fungus | |||
THL | Antibacterial activity against | [61] | |
Extracellular complex of glycolipids (crude extracts and purified fractions) | Antiviral activity against HSV-1 and human coronavirus HCoV-OC43. Antiproliferation activity against human prostatic carcinoma cell line PC3 | [62] | |
Crude trehalolipids | Anti-adhesive activity against exponentially growing Gram-positive bacteria | [63] | |
Mixture of TDM, diacyltrehalose and monoacyltrehalose isolated by column chromatography | [64] | ||
[65] | |||
Glycolipid | [66] | ||
Monoacyltrehalose fraction (MAT) | [67] | ||
Analogues of STL-3 | Inhibited growth and induced the differentiation of human HL-60 promyelocytic leukaemia cell line | [66] | |
Purified oligosaccharide lipids | Antimicrobial activity against Gram-positive bacterial strain of | [67] |
Biomedical research on biosurfactants produced by MACA.
The amphipathic nature of biosurfactants makes them suitable for anti-adhesion and anti-biofilm applications such as the development of anti-adhesive coatings for intra-urinary devices that are prone to the formation of intractable biofilms, to prevent or delay the onset of biofilm growth by pathogens such as
Glycolipid bearing mycolic acids, such as trehalose dimycolate (TDM) have attracted extensive investigation as they play a central role in pathogenesis during infection by intracellular pathogens such as
Although biologics including surfactants are generally regarded as less toxic than synthesized pharmaceuticals not much work has focussed on this with respect to MACA surfactants. However, a THL from
Biosurfactants have a range of promising, and increasingly important, applications in the environmental, industrial, and agricultural sectors (Table 6). These include bioremediation of both organic pollutants (especially hydrocarbons) and metals, microbial enhanced oil recovery (MEOR), cleaning and maintenance of tanks and pipelines in the petroleum industry, wastewater treatment, and agricultural applications such as promotion of plant growth/health and inhibition of phytopathogenic fungi [1, 78]. MACA-derived surfactants have been investigated in some of these contexts, although the focus is on well-known species such as
Application | Examples of MACAs | Reference/s |
---|---|---|
Bioremediation: enhanced hydrocarbon solubility and degradation | [15] [33] [34] [32] [17] [29] [23] | |
Bioremediation: soil washing | [30] [71] | |
MEOR | [72] [73] [74] [24] | |
Bio-demulsification: treatment of water-oil emulsions generated during processing of petroleum | [75] | |
Paraffin control in oil transport pipelines | [76] | |
Bioflocculation (e.g., for oil recovery from wastewater) | [77] |
Various potential environmental applications of biosurfactants produced by MACA.
Pollution of soils with organic and inorganic chemical compounds is a major environmental issue. Biosurfactants are used to improve the solubility of hydrocarbon organic compounds, either to make them available for subsequent biodegradation or to facilitate removal by soil washing. A remediation agent called JE1058BS containing biosurfactant from
The properties and actions of biosurfactants make them particularly relevant to the petroleum industry. MEOR is perhaps the most well-known application in this area. Biosurfactants, or biosurfactant-producing microorganisms, are used to extract some of the oil remaining in reservoirs after primary and secondary processing has been carried out. Mechanisms include reduction of capillary forces holding the oil in porous rock, stabilisation of desorbed oil in water and increased viscosity of oil for easier removal [83].
Biosurfactants may also be used to de-emulsify water–oil emulsions that form during oil production in the oilfields, as well as during transportation, and processing and offer a more ecologically friendly solution than chemically synthesized de-emulsifiers. A lipopeptide bio-demulsifier produced by
Biosurfactants have been shown to reduce phytotoxicity of heavy metals, and pre-treatment of seeds could allow plants to be grown successfully in contaminated soil, facilitating phytoremediation of the environment. Crude biosurfactant from
The use of biosurfactants in environmental and industrial applications is limited by the current high costs of production, and the large amounts of biosurfactant required. However, using waste and/or renewable substrates would be cheaper, and a highly purified product is not essential so costs of downstream processing can also be reduced. In addition, different approaches such as selective stimulation of biosurfactant producers
Currently, commercial production of biosurfactants is not economically competitive with chemical surfactant production as there are various challenges to overcome. Bioprocesses presently achieve low biosurfactant productivity and yield and substrates are expensive [6]. Foam formation can cause serious operational issues and downstream biosurfactant recovery can be technically involved and costly. Development work to optimise bioprocesses should focus on enhancing biosurfactant yield and potency. Approaches include the search and discovery of novel biosurfactant-producing organisms and strain improvement by various genetic engineering methods and/or stress-fermentation including co-cultivation [84]. Yield can also be enhanced through the optimisation of culture conditions and costs reduced through the introduction of renewable or waste products [6, 28, 77] as cheaper feed stocks. The effects of biosurfactants on human health and the environment also require further assessment to ensure safe production and use.
Biosurfactants offer an attractive proposition for biotechnological application across various sectors and are considered superior to synthetic surfactants. Diverse MACA produce biosurfactants with interesting properties that have been explored in the context of biomedicine and environmental remediation. However, many MACA have not yet been investigated for biosurfactant production and various potential applications are yet to receive significant research. Rapid, reliable methods for high throughput screening for biosurfactant production are essential as are robust standard methods for biosurfactant purification and characterisation. Efforts to evaluate and expand the knowledge of structural characteristics and gene regulation of biosurfactants are warranted to improve their effectiveness and productivity. Commercial-scale production will need to employ various existing and new strategies to become economic and sustainable. Cutting-edge technologies such high-throughput omics-based tools should accelerate the development of commercial production of biosurfactants. Furthering our understanding of biosurfactants produced by MACA will facilitate their commercial exploitation thereby contributing to a sustainable bio-based economy.
The authors declare that there is no conflict of interest.
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Integrity - We are consistent and dependable, always striving for precision and accuracy in the true spirit of science.
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\n\nIntechOpen is a dynamic, vibrant company, where exceptional people are achieving great things. We offer a creative, dedicated, committed, and passionate environment but never lose sight of the fact that science and discovery is exciting and rewarding. We constantly strive to ensure that members of our community can work, travel, meet world-renowned researchers and grow their own career and develop their own experiences.
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Generally, the phytochemical constituents of plants fall into two categories based on their role in basic metabolic processes, namely primary and secondary metabolites. Primary plant metabolites are involved in basic life functions; therefore, they are more or less similar in all living cells. On the other hand, secondary plant metabolites are products of subsidiary pathways as the shikimic acid pathway. In the course of studying, the medicinal effect of herbals is oriented towards the secondary plant metabolites. Secondary plant metabolites played an important role in alleviating several aliments in the traditional medicine and folk uses. In modern medicine, they provided lead compounds for the production of medications for treating various diseases from migraine up to cancer. Secondary plant metabolites are classified according to their chemical structures into various classes. In this chapter, we will be presenting various classes of secondary plant metabolites, their distribution in different plant families and their important medicinal uses.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Rehab A. Hussein and Amira A. El-Anssary",authors:[{id:"212117",title:"Dr.",name:"Rehab",middleName:null,surname:"Hussein",slug:"rehab-hussein",fullName:"Rehab Hussein"},{id:"221140",title:"Dr.",name:"Amira",middleName:null,surname:"El-Anssary",slug:"amira-el-anssary",fullName:"Amira El-Anssary"}]},{id:"64851",doi:"10.5772/intechopen.80348",title:"Herbal Medicines in African Traditional Medicine",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14238,totalCrossrefCites:30,totalDimensionsCites:53,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",authors:[{id:"191264",title:"Prof.",name:"Josephine",middleName:"Ozioma",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",middleName:null,surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}]},{id:"54028",doi:"10.5772/67291",title:"Chemical Composition and Biological Activities of Mentha Species",slug:"chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:7483,totalCrossrefCites:13,totalDimensionsCites:47,abstract:"The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea, vomiting, anorexia, and ulcerative colitis. Furthermore, it is well documented that the essential oil and extracts of Mentha species possess antimicrobial, fungicidal, antiviral, insecticidal, and antioxidant properties. The economic importance of mints is also evident; mint oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. To provide a scientific basis for their traditional uses, several studies have been conducted to determine the chemical composition of mints and assess their biological activities. This chapter describes the therapeutic effects and uses of Mentha species and their constituents, particularly essential oils and phenolic compounds; some additional biological activities will also be considered.",book:{id:"5612",slug:"aromatic-and-medicinal-plants-back-to-nature",title:"Aromatic and Medicinal Plants",fullTitle:"Aromatic and Medicinal Plants - Back to Nature"},signatures:"Fatiha Brahmi, Madani Khodir, Chibane Mohamed and Duez Pierre",authors:[{id:"193281",title:"Dr.",name:"Fatiha",middleName:null,surname:"Brahmi",slug:"fatiha-brahmi",fullName:"Fatiha Brahmi"},{id:"199693",title:"Prof.",name:"Khodir",middleName:null,surname:"Madani",slug:"khodir-madani",fullName:"Khodir Madani"},{id:"199694",title:"Prof.",name:"Pierre",middleName:null,surname:"Duez",slug:"pierre-duez",fullName:"Pierre Duez"},{id:"203738",title:"Prof.",name:"Mohamed",middleName:null,surname:"Chibane",slug:"mohamed-chibane",fullName:"Mohamed Chibane"}]},{id:"58270",doi:"10.5772/intechopen.72437",title:"Toxicity and Safety Implications of Herbal Medicines Used in Africa",slug:"toxicity-and-safety-implications-of-herbal-medicines-used-in-africa",totalDownloads:3399,totalCrossrefCites:16,totalDimensionsCites:39,abstract:"The use of herbal medicines has seen a great upsurge globally. In developing countries, many patronize them largely due to cultural acceptability, availability and cost. In developed countries, they are used because they are natural and therefore assumed to be safer than allopathic medicines. In recent times, however, there has been a growing concern about their safety. This has created a situation of ambivalence in discussions regarding their use. Some medicinal plants are intrinsically toxic by virtue of their constituents and can cause adverse reactions if inappropriately used. Other factors such as herb-drug interactions, lack of adherence to good manufacturing practice (GMP), poor regulatory measures and adulteration may also lead to adverse events in their use. Many in vivo tests on aqueous extracts largely support the safety of herbal medicines, whereas most in vitro tests on isolated single cells mostly with extracts other than aqueous ones show contrary results and thus continue the debate on herbal medicine safety. It is expected that toxicity studies concerning herbal medicine should reflect their traditional use to allow for rational discussions regarding their safety for their beneficial use. While various attempts continue to establish the safety of various herbal medicines in man, their cautious and responsible use is required.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Merlin L.K. Mensah, Gustav Komlaga, Arnold D. Forkuo, Caleb\nFirempong, Alexander K. Anning and Rita A. Dickson",authors:[{id:"190435",title:"Dr.",name:"Caleb",middleName:null,surname:"Firempong",slug:"caleb-firempong",fullName:"Caleb Firempong"},{id:"212111",title:"Dr.",name:"Gustav",middleName:null,surname:"Komlaga",slug:"gustav-komlaga",fullName:"Gustav Komlaga"},{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",slug:"arnold-forkuo-donkor",fullName:"Arnold Forkuo Donkor"},{id:"217049",title:"Prof.",name:"Merlin Lincoln Kwao",middleName:null,surname:"Mensah",slug:"merlin-lincoln-kwao-mensah",fullName:"Merlin Lincoln Kwao Mensah"},{id:"217488",title:"Dr.",name:"Alexander K.",middleName:null,surname:"Anning",slug:"alexander-k.-anning",fullName:"Alexander K. Anning"},{id:"223959",title:"Prof.",name:"Akosua Rita",middleName:null,surname:"Dickson",slug:"akosua-rita-dickson",fullName:"Akosua Rita Dickson"}]},{id:"26489",doi:"10.5772/28224",title:"Alternative and Traditional Medicines Systems in Pakistan: History, Regulation, Trends, Usefulness, Challenges, Prospects and Limitations",slug:"alternative-and-traditional-medicines-systems-in-pakistan-history-regulation-trends-usefulness-chall",totalDownloads:9203,totalCrossrefCites:9,totalDimensionsCites:21,abstract:null,book:{id:"542",slug:"a-compendium-of-essays-on-alternative-therapy",title:"A Compendium of Essays on Alternative Therapy",fullTitle:"A Compendium of Essays on Alternative Therapy"},signatures:"Shahzad Hussain, Farnaz Malik, Nadeem Khalid, Muhammad Abdul Qayyum and Humayun Riaz",authors:[{id:"73162",title:"Dr.",name:"Shahzad",middleName:null,surname:"Hussain",slug:"shahzad-hussain",fullName:"Shahzad Hussain"},{id:"82266",title:"Dr.",name:"Farnaz",middleName:null,surname:"Malik",slug:"farnaz-malik",fullName:"Farnaz Malik"},{id:"124185",title:"Dr.",name:"Humayun",middleName:null,surname:"Riaz",slug:"humayun-riaz",fullName:"Humayun Riaz"},{id:"124186",title:"Mr.",name:"Muhammad Abdul",middleName:null,surname:"Qayyum",slug:"muhammad-abdul-qayyum",fullName:"Muhammad Abdul Qayyum"},{id:"125340",title:"Mr.",name:"Nadeem",middleName:null,surname:"Khalid",slug:"nadeem-khalid",fullName:"Nadeem Khalid"}]}],mostDownloadedChaptersLast30Days:[{id:"64851",title:"Herbal Medicines in African Traditional Medicine",slug:"herbal-medicines-in-african-traditional-medicine",totalDownloads:14207,totalCrossrefCites:30,totalDimensionsCites:52,abstract:"African traditional medicine is a form of holistic health care system organized into three levels of specialty, namely divination, spiritualism, and herbalism. The traditional healer provides health care services based on culture, religious background, knowledge, attitudes, and beliefs that are prevalent in his community. Illness is regarded as having both natural and supernatural causes and thus must be treated by both physical and spiritual means, using divination, incantations, animal sacrifice, exorcism, and herbs. Herbal medicine is the cornerstone of traditional medicine but may include minerals and animal parts. The adjustment is ok, but may be replaced with –‘ Herbal medicine was once termed primitive by western medicine but through scientific investigations there is a better understanding of its therapeutic activities such that many pharmaceuticals have been modeled on phytochemicals derived from it. Major obstacles to the use of African medicinal plants are their poor quality control and safety. Traditional medical practices are still shrouded with much secrecy, with few reports or documentations of adverse reactions. However, the future of African traditional medicine is bright if viewed in the context of service provision, increase of health care coverage, economic potential, and poverty reduction. Formal recognition and integration of traditional medicine into conventional medicine will hold much promise for the future.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Ezekwesili-Ofili Josephine Ozioma and Okaka Antoinette Nwamaka\nChinwe",authors:[{id:"191264",title:"Prof.",name:"Josephine",middleName:"Ozioma",surname:"Ezekwesili-Ofili",slug:"josephine-ezekwesili-ofili",fullName:"Josephine Ezekwesili-Ofili"},{id:"211585",title:"Prof.",name:"Antoinette",middleName:null,surname:"Okaka",slug:"antoinette-okaka",fullName:"Antoinette Okaka"}]},{id:"61866",title:"Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants",slug:"plants-secondary-metabolites-the-key-drivers-of-the-pharmacological-actions-of-medicinal-plants",totalDownloads:8875,totalCrossrefCites:56,totalDimensionsCites:140,abstract:"The vast and versatile pharmacological effects of medicinal plants are basically dependent on their phytochemical constituents. Generally, the phytochemical constituents of plants fall into two categories based on their role in basic metabolic processes, namely primary and secondary metabolites. Primary plant metabolites are involved in basic life functions; therefore, they are more or less similar in all living cells. On the other hand, secondary plant metabolites are products of subsidiary pathways as the shikimic acid pathway. In the course of studying, the medicinal effect of herbals is oriented towards the secondary plant metabolites. Secondary plant metabolites played an important role in alleviating several aliments in the traditional medicine and folk uses. In modern medicine, they provided lead compounds for the production of medications for treating various diseases from migraine up to cancer. Secondary plant metabolites are classified according to their chemical structures into various classes. In this chapter, we will be presenting various classes of secondary plant metabolites, their distribution in different plant families and their important medicinal uses.",book:{id:"6302",slug:"herbal-medicine",title:"Herbal Medicine",fullTitle:"Herbal Medicine"},signatures:"Rehab A. Hussein and Amira A. El-Anssary",authors:[{id:"212117",title:"Dr.",name:"Rehab",middleName:null,surname:"Hussein",slug:"rehab-hussein",fullName:"Rehab Hussein"},{id:"221140",title:"Dr.",name:"Amira",middleName:null,surname:"El-Anssary",slug:"amira-el-anssary",fullName:"Amira El-Anssary"}]},{id:"77433",title:"Extraction of Bioactive Compounds from Medicinal Plants and Herbs",slug:"extraction-of-bioactive-compounds-from-medicinal-plants-and-herbs",totalDownloads:1266,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Human beings have relied on herbs and medicinal plants as sources of food and remedy from time immemorial. Bioactive compounds from plants are currently the subject of much research interest, but their extraction as part of phytochemical and/or biological investigations present specific challenges. Herbalists or scientists have developed many protocols of extraction of bioactive ingredients to ensure the effectiveness and the efficacy of crude drugs that were used to get relief from sickness. With the advent of new leads from plants such as morphine, quinine, taxol, artemisinin, and alkaloids from Voacanga species, a lot of attention is paid to the mode of extraction of active phytochemicals to limit the cost linked to the synthesis and isolation. Thus, the extraction of active compounds from plants needs appropriate extraction methods and techniques that provide bioactive ingredients-rich extracts and fractions. The extraction procedures, therefore, play a critical role in the yield, the nature of phytochemical content, etc. This chapter aims to present, describe, and compare extraction procedures of bioactive compounds from herbs and medicinal plants.",book:{id:"10356",slug:"natural-medicinal-plants",title:"Natural Medicinal Plants",fullTitle:"Natural Medicinal Plants"},signatures:"Fongang Fotsing Yannick Stéphane, Bankeu Kezetas Jean Jules, Gaber El-Saber Batiha, Iftikhar Ali and Lenta Ndjakou Bruno",authors:[{id:"224515",title:"Dr.",name:"Fongang Fotsing",middleName:null,surname:"Yannick Stéphane",slug:"fongang-fotsing-yannick-stephane",fullName:"Fongang Fotsing Yannick Stéphane"},{id:"227816",title:"Dr.",name:"Bankeu Kezetas",middleName:null,surname:"Jean Jules",slug:"bankeu-kezetas-jean-jules",fullName:"Bankeu Kezetas Jean Jules"},{id:"227817",title:"Prof.",name:"Lenta Ndjakou",middleName:null,surname:"Bruno",slug:"lenta-ndjakou-bruno",fullName:"Lenta Ndjakou Bruno"},{id:"349790",title:"Prof.",name:"Gaber",middleName:null,surname:"El-Saber Batiha",slug:"gaber-el-saber-batiha",fullName:"Gaber El-Saber Batiha"},{id:"357350",title:"Dr.",name:"Iftikhar",middleName:null,surname:"Ali",slug:"iftikhar-ali",fullName:"Iftikhar Ali"}]},{id:"26491",title:"Homeopathy: Treatment of Cancer with the Banerji Protocols",slug:"homeopathy-treatment-of-cancer-with-the-banerji-protocols",totalDownloads:54048,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"542",slug:"a-compendium-of-essays-on-alternative-therapy",title:"A Compendium of Essays on Alternative Therapy",fullTitle:"A Compendium of Essays on Alternative Therapy"},signatures:"Prasanta Banerji and Pratip Banerji",authors:[{id:"79939",title:"Dr",name:"Prasanta",middleName:null,surname:"Banerji",slug:"prasanta-banerji",fullName:"Prasanta Banerji"},{id:"79943",title:"Dr.",name:"Pratip",middleName:null,surname:"Banerji",slug:"pratip-banerji",fullName:"Pratip Banerji"}]},{id:"54028",title:"Chemical Composition and Biological Activities of Mentha Species",slug:"chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:7474,totalCrossrefCites:13,totalDimensionsCites:46,abstract:"The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea, vomiting, anorexia, and ulcerative colitis. Furthermore, it is well documented that the essential oil and extracts of Mentha species possess antimicrobial, fungicidal, antiviral, insecticidal, and antioxidant properties. The economic importance of mints is also evident; mint oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. To provide a scientific basis for their traditional uses, several studies have been conducted to determine the chemical composition of mints and assess their biological activities. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. 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