Theodora Deftereou

By Panagiotis Tsikouras, Theodora-Eleftheria Deftereou, Anna Chalkidou, Xanthoula Anthoulaki, Anastasia Bothou, Bachar Manav, Zacharoula Koukouli, Stefanos Zervoudis, George Iatrakis and Georgios Galazios

Adolescence is the transitional period between childhood and adulthood. Depending on female gonads’ function and on hypothalamic-pituitary-ovarian axis activation, results in teenager’s body growth, in secondary sex characteristics’ development and finally in their reproductive potential. In adolescence, the negative feedback of gonadal steroids on gonadotropins is disturbed. Teenagers presenting with dysfunctional bleedings are usually suspected of hemorrhagic ovarian cysts or endometriosis and require gynecologic examination, evaluation, and hormone therapy. It is of great importance both for teenagers and their parents to understand that hormone therapy is the first line treatment for bleeding disorders in these ages. A detailed medical history is necessary to determine the appropriate treatment plan. Primary care includes the detection of adolescents with acute or chronic pelvic pain that may be associated with endometriosis or other pathologies like mullerian duct abnormalities, imperforate hymen, ovarian teratomas, ovarian torsion, and vaginal absence or atresia. Mullerian duct abnormalities are associated with increased rates of unexplained infertility, spontaneous abortions, and pathological conditions of pregnancy. Specialists, should help teenagers in getting familiar to their bodies, to their sexuality, inform them about the sexually transmitted diseases, and safety options including vaccination and guide them in contraception issues.

Part of the book: Family Planning

By Panagiotis Tsikouras, Xanthoula Anthoulaki, Theodora Deftereou, Anastasia Bothou, Anna Chalkidou, Fotis Gasparos, Georgia Saradi, Dimitrios Tzeferakos, Elefterios Chatzimichael, Georgios Iatrakis, Stefanos Zervoudis and Georgios Galazios

The cancer of the vulva is a rare disease with a positive association to poor developing countries. However, the incidence of vulvar cancer in situ nearly doubled in the last two decades and remained relatively stable. The main reason for this increased incidence of vulvar intraepithelial neoplasia (VIN) in women younger than 45 years is due to changes in sexual behavior, first intercourse at early age, multiple sexual partners, and sexually transmitted diseases that were increasing progressively. Furthermore, it is strongly associated with smoking and the increased incidence of HPV infection. The occurrence of early symptoms of VIN-like pruritus vulvae, pain, and lichen sclerosus led to early diagnosis to perform the adequate treatment. VIN tends to appear multifocal, while most invasive cancers are unilateral located and appeared with well-circumscribed lesions.

Part of the book: Depigmentation

By Panagiotis Tsikouras, Theodora Deftereou, Xanthoula Anthoulaki, Anastasia Bothou, Anna Chalkidou, Anna Christoforidou, Elefterios Chatzimichael, Fotini Gaitatzi, Ioannis Tsirkas, Arsou Chalil Bourazan, Eirini Bampageorgaka, Georgios Iatrakis, Stefanos Zervoudis, Werner Rath and Georgios Galazios

Thromboembolic disease during pregnancy is a significant cause of maternal morbidity and mortality involving venous or arterial thrombosis and possible clinical manifestations like clinical symptoms of antiphospholipid antibody syndrome and hyperhomocysteinemia. For diminishing the prevalence of thromboembolic disease, the early identification of pregnant women with various risk factors for thrombosis without clinical symptoms is of great importance. However, the optimal management for asymptomatic pregnant women who have inherited thrombophilia is uncertain and recognized only due to pregnancy complications such as recurrent pregnancy loss and preeclampsia. The clinical approach to thromboembolism is the same in pregnant women with or without thrombophilia. Based on family history, clinical symptoms should begin with simple reliable inexpensive laboratory tests like prothrombin time and activated thromboplastin time to test the status. Early diagnosis and appropriate use of thromboprophylaxis lead to increasing better maternal and perinatal outcomes. Conclusively, it is important to recognize these patients in order to prevent all pregnancy complications.

Part of the book: Embolic Disease

By Panagiotis Tsikouras, Theodora Deftereou, Xanthoula Anthoulaki, Anastasia Bothou, Anna Chalkidou, Fotini Gaitatzi, Ioannis Tsirkas, Arsou Chalil Bourazan, Eirini Bampageorgaka, George Stanulov, Elefterios Chatzimichael, Spyridon Michalopoulos, Panagiotis Petsidis, Georgios Iatrakis, Stefanos Zervoudis, Maria Lambropoulou, Werner Rath and Georgios Galazios

The miscarriages’ investigation should include a familiar history, gynecological examination and a full laboratory testing including hormonal control, as well as karyotype, maternal immune control and thrombophilia testing. If the physician suspects the cause of abortions is chromosomal due to heredity, a special blood test (karyotype) for the pair is recommended. Chromosomal abnormalities are the most common reason for first trimester abortions, and are impossible to be prevented. Based on the above data, abortion and the subsequent possible infertility should not be considered as a personal failure for the woman and the treating physician. Nowadays, medical advancement provides many options combined with psychological support can actually reduce the miscarriages’ risk.

Part of the book: Induced Abortion and Spontaneous Early Pregnancy Loss

By Panagiotis Tsikouras, Xanthoula Anthoulaki, Theodora Deftereou, Anna Chalkidou, Anastasia Bothou, Fotini Gaitatzi, Eleftherios Chatzimichael, Selma Gyroglou, Arsou Chalil Bourazan, George Stanulov, Spyridon Michalopoulos, John Tsirkas, Irene Babageogaka, Werner Rath, Georg-Friedrich Von Tempelhoff, Stefanos Zervoudis, Georgios Iatrakis, Georgios Galazios and Nikolaos Nikolettos

Deep vein thrombosis (DVT) of the lower limbs is a serious condition that can lead to pulmonary embolism (PE) in about 15–24% of cases. If it is not diagnosed/treated timely, nearly 15% of these PE are lethal. The relationship between travel and staying in the same position for a long time is well-known since World War II. Generally, it is more frequent in air flights. It is also associated with the economic downturn in airplanes because passengers have limited space and have greater difficulty of moving. It is estimated that approximately 1–6% of long-haul passengers arrive at their destination with a clot in their veins, but most DVT are asymptomatic.

Part of the book: Tourism