The asthma syndrome has many manifestations, termed phenotypes that arise by specific cellular and molecular mechanisms termed endotypes. Understanding helps clinicians make rational therapeutic decisions. Omalizumab has been widely used in clinical practice in Europe and America for over a decade as an add-on therapy to treat patients who have severe asthma. These real-world clinical effectiveness studies have confirmed the benefits, cost-effectiveness, and clinical utility. The purpose of this review is to present the effects of anti-IgE treatment in severe non-atopic asthma and in asthma-COPD overlap syndrome (ACOS). This study describes that the use of omalizumab therapy reduces IgE expression and IgE sensitization of target cells within the bronchial mucosa while exerting a favorable effect on lung function in the short term, as assessed by changes in forced expiratory volume in 1 s (FEV1).
Part of the book: Asthma Diagnosis and Management