Amount of mRNA depends on the both the rates of mRNA transcription in the nucleus and mRNA degradation in the cytoplasm. Although each of the processes was studied independently, recent studies demonstrated the interplay between transcription and mRNA degradation in various cellular processes, such as cell-cycle, cellular differentiation, and stress responses. In this review, we discuss the benefit of the interplay in the gene expressions and the mechanisms how these two processes are coupled. We also review recent genome-wide methods to measure the rates of transcription and degradation.
Part of the book: Gene Expression and Regulation in Mammalian Cells