Limitations of unimodal biometrics.
\r\n\t
",isbn:"978-1-80355-403-7",printIsbn:"978-1-80355-402-0",pdfIsbn:"978-1-80355-404-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"360fe5dabd12a1f91a5658a5fe3eff66",bookSignature:"Associate Prof. Murat Eyvaz and Dr. Ahmed Albahnasawi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11934.jpg",keywords:"Hydrogen Sources, Hydrogen Production, Hydrogen Safety, Hydrogen Storage Methods, Environmental Impacts of Hydrogen, Synthetic Fertilizer Production, Aromatization, Hydrocracking, Hydrodesulfurization, Fuel Cells, Gas Turbines, Hydrogen Driven Vehicles",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 18th 2022",dateEndSecondStepPublish:"March 18th 2022",dateEndThirdStepPublish:"May 17th 2022",dateEndFourthStepPublish:"August 5th 2022",dateEndFifthStepPublish:"October 4th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Eyvaz is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers and has four patents on wastewater treatment systems.",coeditorOneBiosketch:"Dr. Albahnasawi is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers on water and wastewater treatment and waste remediation.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"170083",title:"Associate Prof.",name:"Murat",middleName:null,surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz",profilePictureURL:"https://mts.intechopen.com/storage/users/170083/images/system/170083.png",biography:"Dr. Murat Eyvaz is an associate professor in the Environmental Engineering Department, Gebze Technical University, Turkey. His research interests include applications in water and wastewater treatment facilities, electrochemical treatment processes, filtration systems at the lab and pilot-scale, membrane processes (forward osmosis, reverse osmosis, membrane bioreactors), membrane manufacturing methods (polymeric membranes, nanofiber membranes, electrospinning), spectrophotometric analyses (UV, atomic absorption spectrophotometry), chromatographic analyses (gas chromatography, high-pressure liquid chromatography). He has co-authored many journal articles and conference papers and has taken part in many national projects. He serves as an editor and reviewer for many indexed journals. Dr. Eyvaz has four patents on wastewater treatment systems.",institutionString:"Gebze Technical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Gebze Technical University",institutionURL:null,country:{name:"Turkey"}}}],coeditorOne:{id:"323629",title:"Dr.",name:"Ahmed",middleName:null,surname:"Albahnasawi",slug:"ahmed-albahnasawi",fullName:"Ahmed Albahnasawi",profilePictureURL:"https://mts.intechopen.com/storage/users/323629/images/system/323629.png",biography:"Dr. Ahmed Albahnasawi is a post-doctorate fellow in the Environmental Engineering Department, Gebze Technical University, Turkey. His graduate work focused on the investigation of the treatability of the sequential anoxic-aerobic batch reactors followed by ceramic membrane for textile wastewater treatment. Based on his Ph.D. research, Dr. Albahnasawi published three journal articles and participated in three international conferences. His research interests include the application and design of a microbial fuel cell integrated with Fenton oxidation for industrial wastewater treatment/solid waste management and monitoring of organic micropollutants by both chromatographic and spectrophotometric analyses.",institutionString:"Gebze Technical University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Gebze Technical University",institutionURL:null,country:{name:"Turkey"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6732",title:"Desalination and Water Treatment",subtitle:null,isOpenForSubmission:!1,hash:"eee2f03e0328f289e68fde28738c333f",slug:"desalination-and-water-treatment",bookSignature:"Murat Eyvaz and Ebubekir Yüksel",coverURL:"https://cdn.intechopen.com/books/images_new/6732.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6665",title:"Advances In Hydrogen Generation Technologies",subtitle:null,isOpenForSubmission:!1,hash:"99ccb9f2118953ff45f33ec391868157",slug:"advances-in-hydrogen-generation-technologies",bookSignature:"Murat Eyvaz",coverURL:"https://cdn.intechopen.com/books/images_new/6665.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8804",title:"Water and Wastewater Treatment",subtitle:null,isOpenForSubmission:!1,hash:"ccb46d6518786712b3184b2498fb0cab",slug:"water-and-wastewater-treatment",bookSignature:"Murat Eyvaz",coverURL:"https://cdn.intechopen.com/books/images_new/8804.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8178",title:"Water Chemistry",subtitle:null,isOpenForSubmission:!1,hash:"18595695f271583e06b7c2d33b670e56",slug:"water-chemistry",bookSignature:"Murat Eyvaz and Ebubekir Yüksel",coverURL:"https://cdn.intechopen.com/books/images_new/8178.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7693",title:"Green Chemistry Applications",subtitle:null,isOpenForSubmission:!1,hash:"9db61c9d52045d034f1ee6b769acccd5",slug:"green-chemistry-applications",bookSignature:"Murat Eyvaz and Ebubekir Yüksel",coverURL:"https://cdn.intechopen.com/books/images_new/7693.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7237",title:"Energy-Efficient Approaches in Industrial Applications",subtitle:null,isOpenForSubmission:!1,hash:"a7b403a3af7828987f078b91334839bb",slug:"energy-efficient-approaches-in-industrial-applications",bookSignature:"Murat Eyvaz, Abdülkerim Gok and Ebubekir Yüksel",coverURL:"https://cdn.intechopen.com/books/images_new/7237.jpg",editedByType:"Edited by",editors:[{id:"170083",title:"Associate Prof.",name:"Murat",surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"66768",title:"Zinc-Binding B-Box Domains with RING Folds Serve Critical Roles in the Protein Ubiquitination Pathways in Plants and Animals",doi:"10.5772/intechopen.85895",slug:"zinc-binding-b-box-domains-with-ring-folds-serve-critical-roles-in-the-protein-ubiquitination-pathwa",body:'Protein ubiquitination is an essential cellular process that maintains protein homeostasis (proteostasis) and removes aggregated and misfolded protein that could recruit other proteins away from their normal cellular functions. It serves to regulate protein and cellular functions. Dysregulation of any of the protein component usually result in human diseases including cancers and birth defects. As such, the focus on protein ubiquitination has grown significantly in the past 2 decades, leading to extensive knowledge and new insights. A member of the ubiquitination cascade that has received considerable attention involves the large and growing family of E3 ligases. This family directs the last step in the reaction cascade by facilitating the ubiquitination of protein substrates. It is generally accepted that each E3 ligase has a specific or group of substrates (Figure 1).
Zinc-binding and structure of RING and B-box domains. A. Cross-brace zinc-binding mechanism by Cys/His-rich sequences of RING and B-box domains. Unlike other zinc-finger domains in which the zinc ion is coordinated by Cys and His ligands in a sequential manner, the cross-brace mechanism involves coordination by alternating pairs of ligands. The consensus zinc-binding sequences are different for RING and the B-box domains. B. Ribbon drawings of a representative RING (pdb 2hdp) domain and MID1 B-box1 (2ffw) and B-box2 (2dq5) domains. The ββα-canonical RING fold consists of a short α-helix and two loops, both of which contribute ligands to bind the zinc. Loop1 (L1) is usually less mobile than loop2 (L2). The relative locations of the zinc ions (red spheres) are similar among RING domains and the B-box domains. C. The superposition of structures of the B-box1 and B-box2 domains shows that the overall structures are similar. The structure is rendered to smooth out variation of the loop to simplify the image.
There are several subgroups of E3 ligases, with the largest consisting of proteins with a RING domain that confer ligase functionality. The RING E3 ligase domains are cysteine- and histidine-rich sequences that bind two zinc ions in a unique cross-brace manner and adopt a canonical ββα-fold (Figure 1).
B-box and RING domains fall under the category of zinc-finger domains, which are present in a diverse family of proteins that includes transcription factors, ribonucleoproteins, proto-oncoproteins, and E3 ligases [1]. Zinc-finger domains or proteins are characterized as having cysteine and histidine residues arranged in one of several motifs that are relatively conserved in other proteins [2]. The thiol group (S−) of the cysteine and a nitrogen atom of the histidine imidazole side-chain tetrahedrally bind a zinc ion [2].
Most zinc-finger proteins typically coordinate either a single zinc ion or two zinc ions, depending on the number of cysteine and histidine residues and their position within the sequence [3]. A defining property of zinc-finger domains is that zinc coordination is required to stabilize the tertiary structure. Loss of zinc coordination by a mutation of any of its cysteine or histidine residue results in complete unfolding of the protein structure. Protonation of the cysteine or histidine by decreasing the pH of the protein solution will also result in unfolding. For domains that bind two zinc ions, disruption of coordination of one zinc ion is usually accompanied by the loss of binding of the other zinc ion, causing the domain to become unfolded rather than partially folded with one zinc ion [4, 5].
Zinc-finger domains were identified in the mid-1980s within the
For the next 2 decades, the number of proteins observed with the RING and B-box domain pairs would have increased, with most belonging to TRIM proteins that are defined by their N-terminal RING, B-box, and coiled-coil (RBCC) domains [11, 12]. This RBCC domain arrangement is conserved and found in all multicellular organisms [12]. In humans, the RBCC domain is observed in a family of over 50 proteins; although few have been characterized in detail, their importance is underscored by the fact that some are oncoproteins (e.g., PML, RFP, and TIF1a), while others, when mutated, give rise to various congenital abnormalities [13, 14]. Members of this large protein family are found to play regulatory roles in a variety of cellular processes, including sperm vesicle exocytosis and intracellular release of HIV [15, 16]. The RBCC domain arrangement indicates at the very least that TRIM proteins have an overall common function. The RBCC proteins can have quite diverse C-terminal domain arrangements [17].
Interestingly, many TRIM proteins possess three consecutive cysteine/histidine-rich regions, the first being the RING domain. The other two domains are referred to as B-box1 and B-box2 domains ([18]). While the nomenclatures suggest that the two types of B-box domains are homologous, they do not share any discernable sequence similarity with each other or with RING domains. A single B-box domain in TRIM proteins is always of the type 2 form (B-box2), while TRIMs with two have the B-box1 domain preceding the B-box2 domain. The name may have persisted to prevent confusion in distinguishing the presence of the two types of B-box domains in TRIM proteins. The B-box1 domain is slightly larger (50–60 aa) with a zinc-binding consensus sequence of C-X2-C-X7–12C-X2-C-X4-C-X2-[C/H]-X3–4-H-X4–9-H
Despite their prevalence and location downstream of RING domains in TRIM proteins, very little was initially done to characterize the structures and functions of B-box domains. We postulate that this might have been so because of difficulties in obtaining sufficient quantities of the B-box domains for structural and functional studies. Indeed, each type of the B-box domain has proven to be quite challenging to express and purify using
The first comprehensive structural studies of B-box domains were based on the TRIM18/MID1 protein [13, 21]. Human MID1 is required for proper midline development during embryogenesis ([22, 23, 24, 25, 26]). Mutations of MID1, some of which are found within the B-box domains, are associated with X-Linked Opitz G/BBB syndrome (XLOS), a congenital disorder characterized by clefts of the lip and palate, cardiac structural defects, and genital anomalies [14, 27].
The structure of the B-box1 domain (residues Gln87-Pro165) was solved in 2006 by analyzing multidimensional data acquired by nuclear magnetic resonance (NMR) spectroscopy. The B-box1 domain was observed to coordinate two zinc ions in a cross-brace manner with six cysteine and two histidine residues (Figure 1) [13]. Residues Ala115 to Pro165 form the core of the structure, while the preceding 30 amino acids are unstructured and initially included to aid in solubility. The structure consists of a two-turn α-helix that is preceded by a long structured loop consisting of two short β-strands separated by a type-2 β-turn. Two cysteine residues within the first part of the structured lasso-like loop1 coordinate one zinc ion with two other cysteine residues located within the first helical turn of the helix. Two cysteine residues that are part of the β-turn and two histidine residues, one located at the end of the α-helix and the other on the loop2 that follows the helix, coordinate the second zinc ion. The overall structure is very similar to the ββα-canonical RING fold (Figure 1).
The structure of MID1 B-box2 domain was solved a year later, using NMR data. In contrast to the MID1 B-box1 domain, the MID1 B-box2 consists of seven classical cysteine and histidine zinc-binding residues, suggesting that only one zinc might be coordinated by four of these residues (Figure 1). Sequence alignment of TRIM B-box2 domains reveals that approximately half of B-box2 domains consist of aspartate residues and the other half a cysteine residues in the same location. This observation suggests that Asp must be a highly conserved change [21] that should be performing the same role as the cysteine residue. Indeed, the MID1 B-box2 domain coordinates two zinc ions in a similar cross-brace manner as the B-box1 and RING domains. Two histidine, cysteine, and aspartate residues coordinate one zinc ion. The carboxylate oxygen of this conserved aspartate side chain participates in zinc coordination. The aspartate residue forms the necessary zinc-knuckle conformation with a cysteine residue two positions away (CxxD) to tetrahedrally coordinate the zinc ion [2, 21]. Although carboxylate groups are involved in binding catalytic zinc ions, for example, carbonic anhydrase [28, 29, 30], or other non-structural metals, this was the first demonstration in a zinc-finger protein. The B-box2 domain adopts a two-turn α-helix, two short β-strands separated by a type-2 β-turn, and two structured loops adjacent to the helix. Despite a lack of sequence similarity, the structures of the two types of B-box domains are remarkably similar (Figure 1C). The positions of the two zinc ions are in similar locations, namely near the N-terminus of the helix and to the bottom left of the helix (given the specific orientation shown in Figure 1B). Importantly, the mechanism of zinc coordination (cross-brace) and the ββα-fold are comparable to those of RING domains.
Structures of the B-box1 domain from TRIM19 and the B-box2 domain from TRIM1/MID2, TRIM5α, TRIM21, TRIM29, TRIM39, TRIM41, TRIM54, and TRIM63/MuRF1 have been solved. All the B-box domain structures are similar. Consequently, we conclude that MID1 consists of three consecutive domains with RING folds. Thus, the TRIM protein family must represent a new class of E3 RING-type ligase, consisting of two or three consecutive RING folds.
To identify a possible role of the two adjacent B-box domains, the structure of both was determined in their native tandem form (res A110-E214). The two B-box domains maintained their original structures and pack against each other with the interface formed by residues located on the structured loop-1 near the two antiparallel β-strands. The surface area of the interface is 188 Å2 (17% of the total surface). Interestingly, the tandem globular structure is very reminiscent of the intermolecular association observed for heterodimeric RING structures, such as the BARD1 and BRCA1 domains (12) and the polycomb group protein (Bmi-1) and Ring1B polycomb group (14), and the homodimeric RINGs, such as HDM2 [31], RNF4 and 8 [32, 33], and cIAP2 [34]. The TRIM19 B-box1 and TRIM54 B-box2 domains were solved as symmetric dimers by X-ray crystallography. The structures of RING dimers reveal the domains interacting via residues located on and near loop-1. The BRCA1-BARD and RNF8 dimers also include adjacent structures, such as helical dimers. The area of the interface of the hetero- and homo-RING dimers is approximately 150–200 Å2, similar to that observed for the MID1 B-box1,2 heterodimer. In spite of their interactions, it appears that in the case of MID1, unfolding of the B-box1 structure, via a mutation of one its zinc-binding residues, had little effects on the structure and stability of the B-box2 domain [4]. This observation suggests the possibility that each B-box domain could function independently or have redundant E3 ligase function.
The structures of two B-box domains were solved in complex with another TRIM domain. The TRIM5α B-box2 was crystallized with its coiled-coil domain, which contributes to oligomerization. Binding studies using NMR and dynamic light scattering using a TRIM5α proteins with a native and mutant B-box2 domain reveal that the B-box2 domain contribute to higher order self-association [35]. Given that the B-box2 domain is required for substrate ubiquitination, self-association may contribute to enhanced E3 ligase activity and substrate targeting [36, 37] of the native TRIM5α. The B-box domains of TRIM27 are also determined to be crucial for multimerization by possibly helping to orient the coiled-coil domain in a way that maintained the multimer interaction [38]. In contrast, the B-box2 domain of TRIM21 was crystallized with the N-terminal RING domain, and the structure reveals that the B-box2 domain interacts with the RING domain on a surface that is important for RING-E2 interaction. In this case, the structure suggests that TRIM21 B-box2 may have an autoinhibitory effect, although further studies are required. It is possible that the structures of these complexes may be affected by protein packing within the crystal lattice. More work needs to be done to understand the mechanism of function of these B-box domains, which we postulate are now key players in the ubiquitination field.
In order to appreciate the function of RING and B-box domains, a brief summary of protein ubiquitination is provided. All living organisms employ a fairly common mechanism to recycle proteins so as to regulate protein function, proteostasis, and cell cycle. Eukaryotic cells employ protein ubiquitination, a post-translational modification using the highly stable 76-amino acid ubiquitin protein (Ub) [39, 40, 41]. Bacteria use prokaryotic ubiquitin-like protein (Pup) in an analogous manner [42]. Polyubiquitinated proteins, usually with a chain of at least four-linked Ub, are targeted to the proteasome where they are proteolytically cleaved into peptides [39, 40, 43]. Ubiquitin chains can form via any of its seven lysine residues or combinations of the seven; homogenous chain links, example K48, promote protein degradation [44, 45, 46], but some have signaling functions [47, 48]. The Ubs are cleaved by deubiquitinating enzymes (DUBS) and recycled [49]. Although mono- and diubiquitinated proteins are directed to the proteasome [50], there is evidence that this level of modification serves a signaling role, in which modified proteins can have their functions and cellular location altered. The monoubiquitination of cytosolic proteins results in translocation to the nucleus to participate in DNA repair, transcription regulation, and inflammatory response [39, 51, 52, 53, 54].
Ubiquitination involves three classes of enzymes. First, the E1-activating enzyme (E1) catalyzes the adenylation of the C-terminal glycine of Ub (Ub~AMP). This phosphoester bond undergoes a nucleophilic attack by the sulfhydryl group of the active site cysteine residue on the E1. In the next step, the Ub is transferred to an active site cysteine residue on a family of E2 conjugating enzymes (E2) to form an activated thioester-linked E2~Ub complex [39, 43]. Typically most types of E2 enzymes require the concerted action of an E3 ligase (E3) to target and facilitate substrate ubiquitination [40, 43]. There are several classes of E3 ligases: the homologous to the E6-AP Carboxyl Terminus (HECT), RING-InBetweenRing-RING families, and RING class [39, 40, 41, 50, 55]. The HECT and RING-IBR-RING families accept the Ub via a trans-thiolation reaction from the E2 before transferring it to the target protein. The RING E3 ligase, which includes the Skp-Cullin-F-box (SCF) complex, U-box, and now the B-box, represents the overwhelming majority of E3 ligases. While the mechanism is unclear, the RING-type ligase binds and places in close proximity to the target protein and the E2 enzyme. With the SCF complex, the RING domain (aka RBX) recruits the E2~Ub, while another SCF subunit (usually, the F-box) binds the substrate. In the last reaction, the E2~Ub thioester bond undergoes a nucleophilic attack (thiolysis) by a lysine residue of the target protein whereby the side-chain amino group forms an isopeptide bond with the C-terminal carboxylate group of Ub. Subsequent Ubs can be attached to other lysine residues of the substrate, but more commonly observed to form a polyubiquitin chain with linkages to one of seven lysine residues of the Ub [39, 40, 43]. Chains can be formed with Lys 6, 11, 27, 29, 33 and the N-terminus (M1) amino group, but the two more common reported linkages involve Lys48 and Lys63 [44]. We argue that the level or amount of polyubiquitination or Ub processivity can be an assessment of the level of E3 ligase activity by a RING protein.
Typically, confirmation that a RING domain/protein possesses E3 ligase activity is accomplished by performing
Expected RING E3 ligase results. Cartoon representation of a Western blot image showing autoubiquitination results in no E3 ligase (ln1), a RING-type E3 with “weak” E3 ligase activity forming mono- and sometimes (di-ubiquitinated) products, and a RING E3 with stronger activities (ln3). The smearing represents polyubiquitinated products with various amounts of Ub on the protein. Substrate ubiquitination will usually mirror the results shown.
As noted, the mechanism of function of RING E3 ligases is unclear, but considerable progress has been made to provide insights. The structures of several E2-RING complexes reveal that the RING domain is positioned ~15 Å from the active site and the thioester linkage between the E2 and Ub [59, 60]. Based on these structures, it is unclear how the RING domain affects reactivity or electrophilicity on the E2~Ub linkage. To gain insights on the role of RING E3 ligases, Klevit and co-workers [61, 62] used molecular dynamic and NMR studies to show that the bound RING E3 ligase promoted a “closed” E2~Ub conformation, whereby the Ub populates one interaction mode with slightly greater frequency. In the absence of a bound RING domain, the covalently attached Ub is highly mobile and does not favor any specific surface of E2 to interact [62]. There is no fixed or stable structure between the Ub and E2 proteins. Promoting the positioning of the Ub to the “back” surface of the E2 reduces steric hindrance for nucleophilic attack by the incoming lysine residue. In addition, key amino acid interactions at the E2-RING binding interface appear to contribute to the activation of the thioester bond. For example, residue Gln92 of UbcH5 (Ube2D1), which is located on a helical turn adjacent to active site Cys-85, forms a hydrogen bond with an arginine or lysine residue on loop-2 of the RING domain. Disruption of this interaction through mutation of Gln92 or the arginine severely disrupts the rate of Ub transfer [62, 63]. In fact, the rate of thiolysis with free lysine, as the substrate, for either mutant is comparable to that of E2~Ub without a bound RING domain. Thus, it is generally accepted, given what is known from the various E2-RING interaction studies that the RING domain contributes allosterically to electrophilicity of the thioester bond.
Given that the B-box domains have similar RING folds, it was postulated to function similarly. First confirmation that the B-box domains possess E3 ligase activity was demonstrated with MID1 [64]. The
Intriguingly, the tandem B-box domains also exhibit weak E3 ligase activity, with no greater level of autoubiquitination activity than that observed with the B-box1 domain [64]. This is in contrast to hetero- and homodimeric RING dimers, which exhibited greater activity than the mono form [32, 33, 65]. The BRCA1-BARD1 complex, in which BRCA1 (breast cancer 1) heterodimerizes with BARD1 (BRCA1-associated RING domain), exhibited enhanced activities compared to BRCA1 alone; BARD1 does not exhibit ligase activity [65, 66, 67, 68]. Enhancements of activities were also observed for MDM2/HDX [69], RNF4 [33], inhibitor of apoptosis (IAP) proteins [70], BMI1-RING1 [71], and membrane-associated RING-CH family of E3 ubiquitin ligases (MARCH1) RING dimers [72], to name a few. The mechanism of E3 ligase enhancement by RING dimers or the lack of enhancement by the MID1 B-box domains is unclear. However, there are several publications that proposed rationales of the role of RING dimers [32, 73], but they will not be discussed here.
Despite the MID1 B-box domains not showing strong ligase activity, studies with TRIM16 revealed that its B-box domains exhibited greater level of activities. There were substantial amount of polyubiquitinated products, as demonstrated by the intensity of the smearing observed by Western blot analysis [74]. Both
To understand the role of the B-box domains in the context of being adjacent to the RING domains, as they are commonly found in TRIM proteins, autoubiquitination assays were performed with the MID1 RING domain in tandem with B-box1 (RING-B-box1 (RB1)) and both B-box domains (RING–B-box1–B-box2 (RB1B2)). The goal was to determine whether each domain functions independently or if they have synergistic contribution to justify a possible evolutional reason for their presence in tandem. In the case of RB1, greater amount of polyubiquitinated products were observed compared with the results of the ubiquitination assay with the RING domain alone [14, 64, 76]. The rate of product formation was qualitatively faster. Whereas polyubiquitinated products were observed with the MID1 RING domain after 120 minutes, polyubiquitinated products were observed within the first 5–10 minutes of the assay with RB1. Similarly, the MID1 RB1B2 protein construct exhibited comparably rapid ligase activity as the RB1 domain construct. Within experimental error, it was difficult to determine whether there was greater or lesser amount of polyubiquitinated products. Therefore, it was difficult to identify the contribution of the B-box2 domain within the RB1B2 construct.
To probe whether the B-box2 domain contributes to ligase activity as part of the RB1B2 construct, a C142S mutation was introduced within the B-box1 domain (RB1*B2). Cysteine-142 coordinates one of the two zinc ions, and its mutations to serine resulted in the loss of coordination of both zinc ions and unfolding of the B-box1 domain [4]. By Western blot, the E3 ligase activity of the RB1*B2 protein construct was indistinguishable from the RB1B2 construct, indicating that the B-box2 domain can compensate for the loss of function of the B-box1 domain. To confirm that the B-box2 domain has the same enhancing role as the B-box1 domain, an RB1* protein construct was designed, and the activity was observed to be similar to that of just the RING domain [64].
These observations indicate that the B-box domains, by some unknown mechanism, appear to enhance the E3 ligase functionality of the adjacent RING domain. It is wholly possible that the enhancement observed could be that both RING and the B-box domains have gained E3 ligase activities, there is some synergy in activities, or that the B-box domains may function as E4 ligases [77, 78, 79, 80]. E4 ligases are domains with a RING fold that enhance the ligase activity of RING E3 ligases. Possible examples of E4-enhancing ligases are the BARD1 and HDMX RING domains. In the mid-2000s, the U-box domain, which adopts a similar ββα-RING fold but without the coordination of zinc ions ([81]), was initially shown to play an E4-enhancing role for RING E3 domains [82]. Subsequently, it was concluded that U-box domains can function as E3 ligases and now represent a new member of the RING-type E3 ligases with a similar mechanism of action as RING domains [61, 83, 84].
The function of the B-box domains of TRIM5α, TRIM25, and TRIM32 is also studied [85, 86]. TRIM5α possesses anti-viral/anti-HIV activities [56, 87]. TRIM25 plays a crucial anti-viral role by ubiquitinating the N-terminal caspase activation and recruitment domains (CARDs) of the recognition receptor RIG-I [86, 88]. Mutations of TRIM32 are associated with limb-girdle muscular dystrophy type 2H. TRIM25 consists of RING, B-box1, and B-box2, while TRIM5α and TRIM32 have the RING and B-box2 domains. TRIM25 possesses both Ub and interferon-stimulated gene 15 (ISG15)-E3 ligase activities [86, 88]. ISGylation serves more of a signaling role, as ISG15-modified proteins have altered functions [89]. For these proteins, the B-box domains are required for enhanced activities. Using thiolysis assays (nucleophilic attack on the thioester of charged E2~Ub by lysine), the role of the B-box domains was assessed for TRIM25 and 32 [86]. The constructs with the RING domain alone marginally activated the reaction, but those including the B-box domains significantly accelerated thiolysis.
In the case of TRIM5α, autoubiquitination assays with monomeric RING alone did not produce polyubiquitinated products/chains. In contrast, the RB2 and RB2CC protein constructs showed considerable increases in activities, which were attributed to the presence of the B-box domain. As control, the RB2*CC protein construct with a destabilizing B-box2 mutant resulted similar levels of ubiquitination products as just with the RING domain [36].
In summary, the results from the RB1, RB1B2, RB1*B2, and RB1* autoubiquitination assays of MID1/TRIM18, TRIM25, and TRIM32 suggest that TRIM proteins with RING and two B-box domains have some redundancies in the enhancement role of the B-box domains. Furthermore, given that the RING-less TRIM16 tandem B-box possesses strong ligase activity adds to the support that the B-box domains can possibly have dual roles, functioning as E3 and E4 ligases.
While the
For all three substrates, full-length MID1 was shown to catalyze their polyubiquitination [14, 76, 91]. The role of the B-box domains for substrate ubiquitination was demonstrated for PP2Ac and alpha4 [14, 76]. With just the RING domain, a weak band was observed on the Western blot, indicating low amount of mono-ubiquitinated products [14, 76]. In contrast, polyubiquitinated products were observed with the RB1 and RB1B2 protein constructs. The results of the assays with the RB1* (C141S) protein construct yielded monoubiquitinated PP2Ac and alpha4 products, confirming the B-box1 domain is important for substrate targeting and polyubiquitination. The RB1*B2 protein construct catalyzed the polyubiquitination of PP2Ac but not alpha4. These results indicate a few things: the B-box binding of protein substrates is a critical role for polyubiquitination, the B-box2 domain can compensate for the unfolded B-box1 domain, and the B-box2 domain can contribute to some B-box1 redundancies in MID1’s overall E3 ligase activity. The levels of ubiquitination of PP2Ac and alpha4 parallel the results observed with the autoubiquitination assays, confirming the various roles of the B-box domains. Similar results were observed with TRIM5α TRIM25, TRIM19/PML, and TRIM63.
TRIM5α targets the HIV capsid protein. Deletion of the B-box2 domain affected oligomerization state, E3 ligase activity, and substrate ubiquitination [35, 37, 56]. TRIM25 targets RIG-I.
Finally and importantly, studies with TRIM27/rfp revealed a central role of the B-box domain in substrate binding and ubiquitination and subsequent degradation [75]. This report was the first demonstration that E3 ligase activity of TRIM27, a TRIM protein with a RING domain, is conferred to the B-box domain instead [75]. This unique finding has not, to our knowledge, been observed with any other TRIM proteins containing both RING and B-box domains.
As noted, we postulate that RING E3 ligases that exhibit different levels of
RING and B-box domain comparison. A. Sequence alignments of five representative RING domains and five B-box1 and B-box2 domains from TRIM proteins. The amino acids involved the two zinc ions are identified in yellow and lines above connecting the corresponding residues consistent with the cross-brace mechanism. Some more conserved hydrophobic residues are colored green, while the acidic and basic residues are colored red and cyan. B. Surface representation of HDM2 RING and the MID1 B-box1 and B-box2 domains displaying the surface in same relative orientation for which the E2 enzyme interacts. Hydrophobic (green), basic (K, R, blue), acid (E, D, red), and uncharged polar (white) regions are shown. The pattern of amino acid type distribution is similar for many of the RING and solved B-box1 and B-box2 structures.
E2-E3 interactions. A. Ribbon representation of the UbcH5/Ube2D1(green)-cCbl RING (purple) complex with the structure of the B-box1 domain (red) superimposed onto the RING domain. In this orientation, loop2 is positioned away from the E2-RING binding interface. Residues of RING loop2 make important E2-binding interaction; similar interactions are not observed with the B-box1 domain. B. Close-up to the E2-binding surface of the fancl RING domain; the dashed line separates the surface of the RING and E2 Ube2T (most of which is not shown for clarity). Consistent with several E2-RING complexes, the E2 enzymes bind on a fairly large hydrophobic surface on one side of the RING domain (
Intriguingly, even though the P151L mutant B-box1 possesses greater activity, substrate ubiquitination assays revealed that the mutation disrupts binding and targeting of the alpha4 protein. This observation strongly supports our hypothesis that RING E3 ligase activities may be a compromise between level of activity and substrate binding, as defined evolutionarily. In unpublished work, we have identified several specific amino acids in RING domains that are important for RING–E2 interaction but that are not present in B-box1 domains. Introduction of these amino acids into the MID1 B-box1 domain resulted in significant increases in auto-ubiquitination activity, including polyubiquitination (unpublished).
In light of our findings that the E3 ligase activity of the MID1 B-box1 domain can be enhanced, we examine the structures of RING and B-box domains to understand if there may be additional features that can rationalize the difference in activities of MID1 RING and B-box domains. While it is not feasible to provide detailed analyses of all the differences between the various RING and B-box domain structures, we make general qualitative comparisons. As noted, the overall structures of RING and B-box domains are similar (Figure 1). In the case of the MID1 B-box domain, the position and size of loop2 may contribute to their decreased E3 ligase activities (Figure 4A). The sequences of a few RING and B-box domain are aligned, and distributions of amino acid types on the E2-binding surface on the RING and B-box domains are depicted for comparison (Figures 3 and 4). There are some key differences in amino acids between the RING and B-box domains that may also contribute to differences in the level of activity. However, those will not be discussed in detail here. The exact mechanism of E2-Bbox binding has not been characterized, and therefore, for the following discussion, we make the assumption that the B-box domains interact with the E2 enzyme in a similar manner as RING domains. The different types of residues (hydrophobic [green], acidic [red], basic [blue], and uncharged polar [gray]) are displayed. We used the HDM2 and human Fanconi anemia (fancl) RING domains [31, 120]. On the E2-binding surfaces, both RING domains (Figures 3 and 4) show predominantly hydrophobic residues. With the structure of the HDM2 RING domain (PDB 2hdp), there is also a large adjacent basic patch on the outer surface of the helix, but its role in E2 binding is not clear. There is also a basic residue on loop2 and a small acidic patch toward the top of the structure, and these participate in Ube2D2 E2 binding. For the fancl RING domain, the large hydrophobic patch is located in same region, but there are no large charged surfaces. Evaluation of fancl-RING-Ube2T complex (PDB 4ccg) reveals that the E2 enzyme interacts predominantly with the hydrophobic region of the RING domain (Figure 4B) [120]. Structures of other RING-E2 complexes reveal similar types of interactions.
In contrast, the hydrophobic patches on the MID1 B-box1 and B-box2 structures are smaller and not as contiguous as those observed with the HDM2 and Fancl RING structures (Figure 3). There are more charged residues on the surface. The PML/TRIM19 B-box1 domain (PDB 2mvw) [121] has more polar residues distributed instead of hydrophobic residues. Two smaller hydrophobic patches are observed on opposite sides. The distribution of residues for the TRIM5α B-box2 domain (PDB 2ecv) is very similar to that of the MID1 B-box1 structure. These comparisons reveal that there are differences in amino acid types at the canonical E2-binding site that might influence the mechanism of interactions between RING and B-box domains with their cognate E2 enzymes and hence the level of activity.
Interestingly, the structure of fancl RING domain with Ube2T E2 reveals that Ube2T does not have a corresponding Gln92 residue to form a hydrogen bond with a basic residue on loop2 of the RING domain, which is present is several RING and U-box domains. Instead, the complementary positions consist of hydrophobic residues, suggesting that allosteric effects of RING binding might be transmitted via hydrophobic interactions. In contrast, the HDM2 RING domain has an arginine that can form a hydrogen bond with Gln92 of the Ube2D2/UbcH5 E2 enzyme. This interaction is important for allosteric effects to influence cleavage of the thioester bond. It is possible that these subtle differences in binding mechanisms might provide a rationale for differences in the level of E3 ligase activities observed for RING-type E3 ligases. Differences in activity may also be due to mismatch in cognate E2-RING partners with
In addition to the above noted roles of the B-box domains, it has been suggested that the presence of MID1 B-box2 domain impacts the binding efficiency of the B-box1 domain to alpha4. Binding studies with the MID1 and alpha4 proteins revealed tightest binding with a RB1 construct and reduction in binding with RB1B2 and larger MID1 constructs [90]. The apparent reduction in RB1-alpha4 binding may due to the B-box2 domain binding in an overlapping site with alpha4 [122]. Interestingly, we saw a reduction of the band intensities of the polyubiquitinated products of both auto- and alpha4-ubiquitinations with RB1B2 [76], indicating that B-box2 domain is regulating the alpha4 interaction. On the other hand, it is possible that the decrease is due to the two B-box domains affecting the RB1B2 interaction with the E2 enzyme.
Another TRIM protein for which the B-box2 domain has been ascribed a possible regulatory function is TRIM21, which is involved in immune signaling and is found in almost all cell types and tissues in mammals. In contrast to MID1, the TRIM21 RING domain exhibited greater ligase activity than the RB2 protein construct [123]. The result is confirmed by the E2~Ub thiolysis assays: the rate of Ub discharge was greater with the RING than with the RB2 domain construct. NMR experiments confirmed that the RING and B-box2 domains interact via the surface important for self-oligomerization [124].
There are currently six characterized human TRIM proteins that lack the N-terminal RING domain: TRIM14, TRIM16 (EBBP), TRIM20 (PYRIN/MEFV), TRIM29 (ATDC), TRIM44 (DIPB), and TRIM66. RINGless TRIM proteins are found in
B-box containing TRIM proteins. Protein family distribution of all currently known TRIM and RINGless TRIM proteins grouped by the presence of the B-box1 and B-box2 domains. Pseudo-TRIM16 and 66 lack a RING domain, and pseudo-TRIM 25 and 69 lack the B-box domains.
TRIM16 is a transcriptional regulator involved in regulating neuroblastoma cell growth, migration, and tumorigenicity [74]. Apparently, it can function as E3 ligase via both homodimerization and heterodimerization with TRIM18, TRIM19, and TRIM24 [125]. The tandem B-box domains are capable of very weak homodimerizing interactions in the absence of the coiled-coil domain.
Very little is known about the other RINGless-TRIM proteins (Figures 5 and 6). TRIM29 is an oncogene that regulates p53 and is overexpressed in many different cancers including breast, lung, bladder, and pancreatic [128, 129]. It can form both homodimers and heterodimers with TRIM1/MID2, TRIM11, TRIM23, and TRIM27 [125]. Despite the lack of the RING domain,
While the mechanism of action is not clear, it is possible that RINGless-TRIM proteins function through homo- or heterodimerization via at least one of its B-box domains. Self-association/oligomerization through the B-box domains is shown to contribute to E3 ligase activity possible via an apparent localized concentration effect.
While the majority of B-box domains are found in mammals, recent publications have identified 32 B-box proteins (known as BBX proteins) in
B-box containing non-TRIM proteins. Protein family distribution of all currently known non-TRIM proteins arranged by the presence of the B-box1 and B-box2 domains. These proteins are generally termed BBX (
Defining specific functions to the B-box domains of BBX proteins is lacking, probably because of their recent realization in plants. Without specifics, a large number of these BBX proteins are postulated to be involved in the ubiquitination pathway. Several BBX proteins are shown to interact with an
While it is clear that there is still much to be learned about TRIM proteins and their E3 ligase activity, there has been a great push toward better understanding of the role of the B-box domains over the past decade. Although the RING domain has received much of the spotlight, it is now clear that the B-box domains are integral for substrate binding/targeting, protein ubiquitination, and enhancement or activation of the ligase activity of TRIM and BBX protein families. B-box domains have diverse roles that include protein-protein interactions, substrate ubiquitination and sumoylation, and transcriptional regulation. What is not clear is whether B-box domain really served as E4-enhancing ligase to enhance the ligase activity of the RING domains, as observed in dimer RING E3 ligases, or whether they synergistically gain activity alongside the RING domains. Their role in contributing to oligomerization for some TRIM and BBX proteins to account for enhanced E3 ligase activity may be due to an apparent increase in the localized concentration of the TRIM or BBX protein. However, more studies are needed. Progress will require multifaceted approaches involving structure determination, protein-protein binding studies, and functional assays. Nonetheless, we hope that sufficient evidence have been provided, including those of TRIM18/MID1 and TRIM27, demonstrating that B-box domains are and should be considered E3 ligases and not as a supporting player to RING domains.
The author thanks Dr. Katharine Wright for her work in the lab and for contributing ideas for this review, and Ms. Jessica Webb for her help and contributions with the figures. This work was supported in part by a National Science Foundation grant (MAM, 1808391).
Biometrics is a technology that uses physical and/or behavioral characteristics of people to identify them. Systems of this type implement two processes (Figure 1) [1]:
Enrollment
Authentication
Biometric recognition system.
The physical features are fingerprints, hand geometry, handprint, facial image, iris, retina, and ear. Behavioral features are signature, lip motion, speech, dynamics of typing, hand movements, and gait.
\nThe characteristics of effective biometrics are:
Unique features for each individual
Invariant traits over time (e.g., due to the effect of aging)
Features that are relatively easy to obtain (computational complexity small)
Precise algorithms enabling classification
Resistance to various types of attacks
Low cost
Ease of implementation
The security of the biometric system is usually assessed on the basis of some indicators. These are:
False match rate (FMR). It belongs to the group of matching errors. This indicator is defined as the expected probability that the downloaded sample will be falsely matched to the template in the database, but it will not be the test user pattern. If the indicator is high, it means that there is a risk that an unauthorized person will be recognized as a system user.
False rejection (FRR) is equivalent to the FMR. The difference between these indicators is that FMR refers to a single match, and the FRR refers to a situation where one or more attempts to match a sample to a template from the database may occur. The FRR error is referred to in the literature as type I error.
False discrepancy (FNMR). This is the coefficient determining the probability that the sample taken will not be matched to the pattern in the database belonging to the user from whom the sample was taken. In biometric verification (1:1) systems, the indicator means that the sample has not been identified by a specific pattern, while in biometric identification systems (1:N), this indicator determines the probability that a given pattern will not be found in the database.
The false acceptance factor (FAR) is equivalent to the FNMR indicator. The difference between him and FNMR is the same as between FRR and FMR.
Equal error rate (EER). It is defined as the intersection of the FAR and FRR characteristics in the graph of the dependence of these errors on the threshold of sensitivity (t). This factor indicates the optimal sensitivity threshold at which the same number of people is incorrectly rejected and incorrectly accepted. The lower the EER error value, the better the biometric system is.
The FMR (FRR) and FNMR (FAR) parameters can also be represented by graphs (Figure 2):
Receiver operating characteristic (ROC) curve showing the dependence of FNMR on FMR. You can use it to show the accuracy of the system.
Detection error trade-off (DET) showing error rates on both axes, most often on a logarithmic scale. This curve is plotted for both matching errors and decisions (Figure 2).
The graph of FAR, FRR, and EER in receiver operating characteristic (ROC) curve.
If we use only one biometric authentication system, the results obtained are not always good enough. Unimodal biometric systems using a single sensor have many limitations, such as lack of uniqueness, universality, and lack of interference level associated with the acquired data, as a result of which they are unable to provide the required level of identification/verification efficiency (Table 1). This is due to the fact that the reliability of the biometric modality applied is affected by the precision of a single biometric system (Table 2).
\nName | \nDescription | \n
---|---|
Distortion of the input biometric data | \nDistorted biometric data may prevent the correct alignment process with database templates, as a result of which users are incorrectly rejected or identified | \n
Intra class variations | \nBiometric data obtained from the person during authentication may differ from the data used to generate the template during registration, thus affecting the matching process. The biometric template should have a small intra-class variance | \n
Interclass similarities | \nBiometric features should be significantly different for different people and should ensure small similarities between classes in the feature space. There is an upper limit to the users who can be effectively distinguished by any biometric system. The capacity of the identification system cannot be arbitrarily increased for fixed sets of feature vectors and the matching algorithm. The biometric template should have large interclass variations | \n
Non-universality | \nObtaining accurate (useful) biometric data from the users is not always possible | \n
Intruder attacks | \nAttacks of this type involve the manipulation of biometric features to avoid recognition. It is also possible to create artificial biometric patterns in order to accept the identity of another person | \n
Limitations of unimodal biometrics.
Name | \nDescription | \n
---|---|
Recognition accuracy | \nThe multi-biometric system ensures greater accuracy and reliability thanks to many independent biometric features that are difficult to attack | \n
Continuous monitoring | \nIn case when one biometric modality is obstructed, other modalities of the multi-biometric system ensure correct user identification | \n
Privacy | \nMulti-biometric systems provide greater resistance to certain types of loopholes and attacks. It is difficult and/or impossible to steal many biometric patterns (templates) stored in the biometric database | \n
Biometric data enrollment | \nWhen biometric input data is unavailable or unacceptable by a biometric system, another biometric system modality may be used | \n
Resistance on spoof attacks | \nUsually the attacker is not able to use many relevant (accurate) spoofed biometrics | \n
Advantages of multi-biometric systems.
The multi-biometric system can be (Figure 3) (a) a multi-sensor system that allows obtaining data from various sensors using one biometric feature, (b) a system with multiple algorithms processing a single biometric feature, (c) a system consolidating multiple occurrences of the same body trait, (d) a system using multiple templates of the same biometric method obtained with the help of a single sensor, and (e) a multimodal system combining information about the biometric features of the individual to establish his identity [2, 3, 4].
\nTypes of multi-biometric systems.
In multimodal biometric systems, there are a number of strategies (scenarios) for the fusion of biometric information:
Data fusion from sensors. Data from various sensors form one vector. Fusion of information obtained from many different sensors for a single biometric feature.
The fusion of feature vectors extracted from various biometric modalities for further processing. A merger of information obtained from several unimodal biometric systems that process different body characteristics of the same person (Figure 4a).
Fusion at the decision level. The merger of decisions developed on the basis of information from different biometric modalities, and the resultant feature vector defines two main classes, i.e., rejection or acceptance (Figure 4b).
Rank level fusion. The classifier determines the rank of each registered biometric identity. A high position is a good indicator of a good fit (Figure 4b).
Levels of fusion. (a) Feature level fusion and (b) score/rank level fusion.
The fusion of biometrics modalities on different levels of multi-biometrics system is extensively studied in the literature (Table 3). For all that the merger at the level of feature vectors is relatively poorly discussed. The merger at this level includes the integration of feature vectors corresponding to many sources of information. Because the feature vectors contain more elements than the input biometric data, it is obvious that the merger at the feature vectors level will provide better authentication results. However, mergers at this level are difficult to implement in practice because (i) sets of features of many modalities may be incompatible, (ii) the combination of two feature vectors may result in a vector of features with very large dimensionality, and (iii) a complex comparing system is required.
\nBiometrics traits | \nFusion methods | \nDescription of the implementation method | \nReferences | \n
---|---|---|---|
Fingerprint and face | \nIn [5], it was proposed to extract face and fingerprint characteristics invariant to the rotation and scaling of Zernike moments (ZM). On the basis of ZM, the fusion of facial features and fingerprints is realized. The RBF network implements the decision-making process. The accuracy rate is 96.55%. Testing result of authentication rate are FAR, 4.95%, and FRR, 1.12% | \n[5] | \n|
Score | \nIn [6], authors presented score level fusion technique using the SIFT features for the face and the minutiae features for fingerprint. Results are: FAR = 1.98%, FRR = 3.18%, and accuracy = 97.41 | \n[6] | \n|
Fingerprint, finger knuckle print, finger vein Finger shape | \nThe multi-set canonical correlation analysis is used to fuse multiple feature sets. The feature based on MCCA achieves the recognition performance, with EER = 2.3900e-04 | \n[1] | \n|
With the help of the unified Gabor filter, fingerprint codes and finger vein codes are generated. The extraction of features is carried out by using a supervised local canonical correlation analysis (SLPCCA), and finally the NN-classifier is used | \n[7] | \n||
Fingerprint and iris | \nScore | \nIn [8], authors propose a frequency approach to generate a unified homogeneous template for fingerprint and iris features. Scores generated from these templates are fused using the sum rule | \n[8] | \n
Palm print and hand shape | \nInformation from the face image and gait image are combined at the function level. Using the principal component analysis (PCA) method, facial features were obtained The result of multiple discrimination analysis (MDA) is gait energy image (GEI) Recognition rate results are 91.3% | \n[9] | \n|
Palm print and iris | \nIn system described in [10], texture parameters are extracted based on Gabor filters. | \n[10] | \n|
Fusion of the palm print features and iris features is based on the wavelets. Decision is obtained using kNN classifier. Recognition accuracy is 99.2% and FRR = 1.6% | \n|||
\n | In [11], fusion method for the information of phases about the iris and palm utilizes a Baud limited image product (BLIP) | \n[11] | \n|
Finger knuckle and palm print | \nIn this paper, feature extraction method for palm print is monogenic binary coding; for inner knuckle print recognition, two algorithms named ridgelet transform and SIFT are proposed. The extracted feature vectors are classified using SVM | \n[12] | \n|
Palm print and face | \nThe PCA is used to extract features of palm and face images. Fusion technique concatenated the feature vectors of the face and palm modalities into one fused vector, and feature selection is performed. | \n[13] | \n|
Face and gait | \nMethod is based on learning face and gait features in image transform spaces. Two methods are considered—PCA and LDA | \n[14] | \n|
Face and iris | \nScore | \nMulti-biometrics system using dual iris, visible and thermal face traits is considered. 1D Log-Gabor and Complex Gabor Jet Descriptor (CGJD) were used to extract feature vectors. Authors proposed a score level fusion algorithm | \n[15] | \n
The ordinal measures and local binary pattern (LBP) methods are proposed to extract features from iris and face regions, respectively | \n[16] | \n||
Paper [17] presents the extractions of iris features based on 2D Gabor and facial features using the PCA method | \n[17] | \n||
Face and hand geometry | \nThe 2D DCT is used to extract discriminant face features which are concatenated with hand geometric features. The resultant feature vector is classified using SVM | \n[18] | \n|
Face and ear | \nScores | \nTo match score level, fusion is proposed in [19]. Authors use Dempster-Shafer decision theory for each modality. Recognition rate is 95.53% with 4.47% EER | \n[19] | \n
Ocular—iris and conjunctival vascular | \nScore | \nIn [4], authors presented fusion of both iris and conjunctival vascular information. A weighted fusion method is proposed for each modality. The fusion resulted in an EER of 2.83% | \n[4] | \n
Face, ear, and signature | \nRank | \nIn [20], the PCA and Fisher’s linear discriminant (FLD) methods in the face, ear, and signature, multimodal biometrics system is proposed. Local features are extracted from face, ear, and signature data. Features are matched using Euclidean distance. This system is using rank level fusion | \n[20] | \n
Summary of works on multimodal biometric systems.
The multi-biometric system (dorsal vein + periocular + palm print) is presented in Figure 5.
\nConsidered multi-biometric system architecture.
In our proposed method, the first is preprocessing block including noise elimination, ROI detection and normalization, and contrast normalization. For all three modalities, noise elimination for an image \n
where \n
Next step in preprocessing phase is ROI detection and normalization (Figure 6). This operation is quite different for dorsal vein images, palm print images, and periocular images. For dorsal vein images, we use distance transform to detect the dorsal image center and build square ROI based on this center coordinates [22, 23]. The ROI design for palm print images is based on hand-specific points (finger valleys) and two angles [24]. The periocular region is detected based on the center of the iris. Using the conventional algorithm for detecting the iris, we determine the center of the iris and its diameter. The periocular area is a rectangle centered in the iris center [25, 26].
\nROI area for dorsal vein images (a), palm print images (b), and periocular images (c).
After the ROI detection, we perform image size normalization and apply the contrast normalization by using CLAHE algorithm. The image is divided into non-overlapping areas of equal size, and the histograms of each region are calculated. Next, the cutoff threshold for histograms is obtained, and each histogram is processed in such a way that its height does not exceed the cutoff threshold [21].
\nThe sample input images after normalization operations and operations using the CLAHE algorithm are shown in Figure 7. Next processing blocks include feature extraction, feature selection, fusion, and classification.
\nImages after normalization (size 150 × 150 pixels) and after applying the CLAHE algorithm.
In biologically inspired vision models, receptor fields exist that are the primary aspect of early visual processing in mammalian vision systems. Gabor functions are widely used in image feature analysis because they are similar to receptive field profiles in mammalian cortical simple cells. These fields are modeled using Gabor filters [27].
\nImitation of mammalian vision systems (or some of them) in object recognition systems leads to their increased efficiency and plausibility. Object recognition systems that are inspired by the biological approach use filter banks, in particular Gabor filters (Figure 8) [28, 29, 30, 31, 32].
\n2D functions and 2D Gabor filter.
The 2D Gabor filter family can be represented as expressed in Eq. (2):
\nwhere \n
The \n
\n\n
Gabor response images are obtained by convolution operation of multiscale and multi-orientation Gabor filters \n
where and\n
The Gabor filter responses for palm print image and dorsal vein image are shown in Figures 9 and 10, respectively.
\nImaginary part of the Gabor filter responses of a palm print image.
Imaginary part of the Gabor filter responses of a dorsal vein image.
The periocular area contains the iris, eyes, eyelids, eyelashes, and partially eyebrows. The
\n
\n
The
where\n
The idea of this operator is presented in Figure 11.
\nThe basic idea of LBP approach.
For an image size \n
where
Using the
Typically image is divided into
In the case \n
The original image (a) and image as a result of the LBP operator (b).
The
The multi-biometric system has been tested using certain parts of the following databases: PolyU palmprint [24], IIITD periocular database [25], and Bosphorus hand vein database [35]. We choose 20 subjects with 10 images per subject at random. From 10 images, 5 images are used for training and 5 for the testing.
\nThe combination of feature vectors at this level is difficult to achieve in practice due to the combination of certain fundamentally different feature vectors that can result in a resulting vector of features with very large dimensionality. In a merger at the level of feature vectors, each individual modality process generates a feature vector. The fusion process combines these feature vectors into one vector.
\nFor dorsal vein images and for palm print images, we perform the same image processing operations that the feature vectors have the same sizes. As a result of convolution operation of multiscale and multi-orientation Gabor filters with the input image, we get the Gabor response images. The feature vector has a very large size of
For periocular images, the feature vector has a size of 36 × 59 = 2124.
\nNext we reduce dimensionality of these vectors used in PCA method (Figure 14 and Table 4) [5]. Separated features are normalized using zero mean and unit variance as
\nSteps to image processing using PCA.
PCA algorithm | \n
Organizing the training set of images \n\n where | \n
Calculating the average of the set T \n\n | \n
Calculating \n\n | \n
Calculating the covariance matrix C \n\n | \n
The eigenvectors and corresponding eigenvalues are computed \n\n | \n
The eigenvectors and their corresponding eigenvalues are paired and ordered from high to low. Approximated image is calculated as \n\n for \n | \n
PCA algorithm.
where \n
\nTable 5 shows the recognition performance depending on the number of selected eigenvectors.
\nModality | \nNumber of the eigenvectors | \n|||
---|---|---|---|---|
k = 40 | \nk = 60 | \nk = 80 | \nk = 100 | \n|
Dorsal vein | \n88 | \n89.3 | \n91.4 | \n92.6 | \n
Palm print | \n88.7 | \n89.3 | \n90.6 | \n92.8 | \n
Periocular | \n86 | \n86.8 | \n89 | \n89.2 | \n
Dorsal vein + palm print | \n90.3 | \n91.1 | \n92.3 | \n93.1 | \n
Dorsal vein + periocular | \n91.1 | \n92 | \n92.4 | \n92.8 | \n
Palm print + periocular | \n90.7 | \n91.4 | \n91.8 | \n92.1 | \n
Recognition rates [%] for different modality.
In this chapter, Gabor’s functions and LBP features are proposed for recognition in a multi-biometric system that uses three modalities: dorsal vein, periocular, and palm print. Using PCA method dimensionality feature vectors from these modality are reduced. Feature vectors are normalized and fused using concatenation operation. Based on the results, we suggest that multi-biometric system using the fusion of dorsal vein, periocular, and palm print images can offer recognition rate which the unimodal biometric system cannot.
\nOve Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.
',metaTitle:"Odredbe i uvjeti",metaDescription:"Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.",metaKeywords:null,canonicalURL:"/page/cro-terms-and-conditions",contentRaw:'[{"type":"htmlEditorComponent","content":"Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
\\n\\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\\n\\nKlijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\\n\\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\\n\\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\\n\\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\\n\\nOsim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\\n\\nMi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\\n\\nIntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\\n\\nMaterijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\\n\\nIntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\\n\\nZadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\\n\\nAko smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\\n\\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\\n\\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\\n\\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Pristupom na stranicu www.intechopen.com slažete se s ovim odredbama, sa svim primjenjivim zakonskim odredbama, te se slažete s poštovanjem svih lokalnih zakona. Korištenje i/ili pristup ovoj stranici temelji se na potpunom prihvaćanju ovih odredbi. Svi materijali na ovoj stranici zaštićeni su primjenjivim zakonima o autorskim pravima i žigu.
\n\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
\n\nKlijent, stranka, vi, vaš odnosi se na vas, osobu koja pristupa ovoj stranici i prihvaća IntechOpenove Odredbe i uvjete;
\n\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\n\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\n\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
\n\nOsim ako nije suprotno navedeno, IntechOpen i/ili svi davatelji licence vlasnici su intelektualnog vlasništva nad svim materijalima na www.intechopen.com. Sva prava intelektualnog vlasništva su pridržana. Stranice sa www.intechopen.com možete gledati, preuzimati, dijeliti, dijeliti poveznice i printati za osobnu uporabu, a temeljem pravila sadržanih u ovim Odredbama i uvjetima.
\n\nMi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
\n\nIntechOpen ili njegovi suradnici niti u jednom slučaju neće biti odgovorni za štete (štete uključuju gubitak podataka ili profita, druge poslovne prekide, te sve ostale štete) koje nastanu zbog korištenja materijala na IntechOpenovoj stranici ili nemogućnosti da se iste koriste, čak i ako je IntechOpen ili njegov predstavnik o takvoj šteti obaviješten pismenim ili usmenim putem. Neke jurisdikcije ne dozvoljavaju ograničenja garancija ili ograničenja obveza za posljedične ili slučajne štete pa se u tom slučaju ova ograničenja možda ne odnose na vas.
\n\nMaterijali koji se pojavljuju na IntechOpenovoj stranici mogu sadržavati manje greške, tipfelere ili fotografske greške. IntechOpen može napraviti promjene na bilo kojem materijalu koji se nalazi na stranici u bilo koje vrijeme.
\n\nIntechOpen nije formalno povezan niti s jednom vanjskom stranicom čije poveznice vode na www.intechopen.com, osim ako to nije izravno navedeno. Iz tog razloga IntechOpen nije odgovoran za sadržaj koji se pojavljuje na takvim stranicama. Poveznica na IntechOpenovu stranicu ne implicira povezanost sa IntechOpenom. Korištenje takvih poveznica isključiva je odgovornost korisnika.
\n\nZadržavamo pravo vlasništva nad cjelokupnom stranicom www.intechopen.com i nad svim materijalom na toj stranici. Koristeći se našim uslugama, slažete se da maknete sve poveznice na našu stranicu odmah nakon što to od vas zatražimo. Također, zadržavamo pravo da ove Odredbe i uvjete, i politiku o poveznicama izmjenimo u bilo koje vrijeme. Koristeći se poveznicama na naše stranice slažete se s ovim Odredbama i uvjetima.
\n\nAko smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\n\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\n\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6581},{group:"region",caption:"Middle and South America",value:2,count:5888},{group:"region",caption:"Africa",value:3,count:2381},{group:"region",caption:"Asia",value:4,count:12507},{group:"region",caption:"Australia and Oceania",value:5,count:1006},{group:"region",caption:"Europe",value:6,count:17528}],offset:12,limit:12,total:132501},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"7"},books:[{type:"book",id:"11439",title:"Crisis Management - Principles, Roles and Application",subtitle:null,isOpenForSubmission:!0,hash:"89fd49a084aea68bc39838042bdfce66",slug:null,bookSignature:"Ph.D. Carine J. Yi",coverURL:"https://cdn.intechopen.com/books/images_new/11439.jpg",editedByType:null,editors:[{id:"200332",title:"Ph.D.",name:"Carine",surname:"Yi",slug:"carine-yi",fullName:"Carine Yi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",subtitle:null,isOpenForSubmission:!0,hash:"8d41fa5f3a5da07469bbc121594bfd3e",slug:null,bookSignature:"Prof. Margherita Mori",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",editedByType:null,editors:[{id:"335401",title:"Prof.",name:"Margherita",surname:"Mori",slug:"margherita-mori",fullName:"Margherita Mori"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11477",title:"Public Economics - New Perspectives and Uncertainty",subtitle:null,isOpenForSubmission:!0,hash:"a8e6c515dc924146fbd2712eb4e7d118",slug:null,bookSignature:"Dr. Habtamu Alem",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",editedByType:null,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11601",title:"Econometrics - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"bc8ab49e2cf436c217a49ca8c12a22eb",slug:null,bookSignature:"Dr. Brian Sloboda",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",editedByType:null,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11603",title:"People Management - Highlighting Futures",subtitle:null,isOpenForSubmission:!0,hash:"982c56a5fb4684d966f8f5e76b2638f5",slug:null,bookSignature:"Dr. Diana Dias and Dr. Carla Magalhães",coverURL:"https://cdn.intechopen.com/books/images_new/11603.jpg",editedByType:null,editors:[{id:"450553",title:"Dr.",name:"Diana",surname:"Dias",slug:"diana-dias",fullName:"Diana Dias"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11774",title:"International Law",subtitle:null,isOpenForSubmission:!0,hash:"9e629251ba38b83f6bf406dd93511c61",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11774.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11775",title:"Global Peace and Security",subtitle:null,isOpenForSubmission:!0,hash:"90d8b5fdb1297222c88ab85dd900297a",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11775.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11776",title:"Fashion Industry",subtitle:null,isOpenForSubmission:!0,hash:"e8d53d1029a7bccf825aa55d43fecc68",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11776.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12133",title:"Agricultural Value Chain",subtitle:null,isOpenForSubmission:!0,hash:"19892b77680b500f259ea7a506365cdc",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12133.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12134",title:"Sustainable Tourism",subtitle:null,isOpenForSubmission:!0,hash:"bb510c876f827a1df7960a523a4b5db3",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12134.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12138",title:"Online Advertising",subtitle:null,isOpenForSubmission:!0,hash:"d1a7aaa841aba83e7199b564c4991cf1",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12138.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12139",title:"Global Market and Trade",subtitle:null,isOpenForSubmission:!0,hash:"8599552a082118a2e26888448aa3fd03",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/12139.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:41},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:6},{group:"topic",caption:"Chemistry",value:8,count:20},{group:"topic",caption:"Computer and Information Science",value:9,count:20},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:59},{group:"topic",caption:"Environmental Sciences",value:12,count:8},{group:"topic",caption:"Immunology and Microbiology",value:13,count:9},{group:"topic",caption:"Materials Science",value:14,count:27},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:122},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:11},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:15},popularBooks:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10351",title:"Enhanced Liposuction",subtitle:"New Perspectives and Techniques",isOpenForSubmission:!1,hash:"f08ed6de16da357614586c5b58ed4dfa",slug:"enhanced-liposuction-new-perspectives-and-techniques",bookSignature:"Diane Irvine Duncan",coverURL:"https://cdn.intechopen.com/books/images_new/10351.jpg",editors:[{id:"279869",title:"Dr.",name:"Diane Irvine",middleName:null,surname:"Duncan",slug:"diane-irvine-duncan",fullName:"Diane Irvine Duncan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10779",title:"21st Century Nanostructured Materials",subtitle:"Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine, and Agriculture",isOpenForSubmission:!1,hash:"72c67f97f9bef68200df115b5fd79884",slug:"21st-century-nanostructured-materials-physics-chemistry-classification-and-emerging-applications-in-industry-biomedicine-and-agriculture",bookSignature:"Phuong V. Pham",coverURL:"https://cdn.intechopen.com/books/images_new/10779.jpg",editors:[{id:"236073",title:"Dr.",name:"Phuong",middleName:"Viet",surname:"Pham",slug:"phuong-pham",fullName:"Phuong Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4386},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3665,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1713,editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",publishedDate:"April 28th 2022",numberOfDownloads:2481,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1107,editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3307,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3266,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1868,editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",publishedDate:"May 4th 2022",numberOfDownloads:856,editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1704,editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7489,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,isOpenForSubmission:!1,hash:"49cce3f548da548c718c865feb343509",slug:"rabies-virus-at-the-beginning-of-21st-century",bookSignature:"Sergey Tkachev",coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10861",title:"Furan Derivatives",subtitle:"Recent Advances and Applications",isOpenForSubmission:!1,hash:"fdfc39cecd82f91b0effac994f75c877",slug:"furan-derivatives-recent-advances-and-applications",bookSignature:"Anish Khan, Mohammed Muzibur Rahman, M. Ramesh, Salman Ahmad Khan and Abdullah Mohammed Ahmed Asiri",coverURL:"https://cdn.intechopen.com/books/images_new/10861.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"293058",title:"Dr.",name:"Anish",middleName:null,surname:"Khan",slug:"anish-khan",fullName:"Anish Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10870",title:"Ultrasound Imaging",subtitle:"Current Topics",isOpenForSubmission:!1,hash:"2f0bc3733ab226d67fa73759ef0e12ad",slug:"ultrasound-imaging-current-topics",bookSignature:"Felix Okechukwu Erondu",coverURL:"https://cdn.intechopen.com/books/images_new/10870.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"68312",title:"Prof.",name:"Felix",middleName:null,surname:"Okechukwu Erondu",slug:"felix-okechukwu-erondu",fullName:"Felix Okechukwu Erondu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",isOpenForSubmission:!1,hash:"86a6d33cf601587e591064ce92effc02",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10400",title:"The Application of Ant Colony Optimization",subtitle:null,isOpenForSubmission:!1,hash:"f4fdfd07ee1ab99fb7c740d6d0c144c6",slug:"the-application-of-ant-colony-optimization",bookSignature:"Ali Soofastaei",coverURL:"https://cdn.intechopen.com/books/images_new/10400.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"257455",title:"Dr.",name:"Ali",middleName:null,surname:"Soofastaei",slug:"ali-soofastaei",fullName:"Ali Soofastaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10915",title:"Leadership",subtitle:"New Insights",isOpenForSubmission:!1,hash:"0d72e79892f2a020cee66a52d09de5a4",slug:"leadership-new-insights",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/10915.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"105529",title:"Dr.",name:"Mário",middleName:null,surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10683",title:"Technological Innovations and Advances in Hydropower Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7ce7ad8768bd2cad155470fe1fd883f4",slug:"technological-innovations-and-advances-in-hydropower-engineering",bookSignature:"Yizi Shang, Ling Shang and Xiaofei Li",coverURL:"https://cdn.intechopen.com/books/images_new/10683.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7102",title:"Pneumonia",subtitle:null,isOpenForSubmission:!1,hash:"9fd70142814192dcec58a176749f1b60",slug:"pneumonia",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"176",title:"Diagnostics",slug:"diagnostics",parent:{id:"16",title:"Medicine",slug:"medicine"},numberOfBooks:61,numberOfSeries:0,numberOfAuthorsAndEditors:2026,numberOfWosCitations:2101,numberOfCrossrefCitations:1247,numberOfDimensionsCitations:2707,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"176",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"9046",title:"Amyloidosis",subtitle:"History and Perspectives",isOpenForSubmission:!1,hash:"371a4ad514bb6d6703406741702a19d0",slug:"amyloidosis-history-and-perspectives",bookSignature:"Jonathan S. Harrison",coverURL:"https://cdn.intechopen.com/books/images_new/9046.jpg",editedByType:"Edited by",editors:[{id:"340843",title:"Dr.",name:"Jonathan S.",middleName:"Scott",surname:"Harrison",slug:"jonathan-s.-harrison",fullName:"Jonathan S. Harrison"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10119",title:"Biomarkers and Bioanalysis Overview",subtitle:null,isOpenForSubmission:!1,hash:"dd70071c0bb32eeedab08909509b1312",slug:"biomarkers-and-bioanalysis-overview",bookSignature:"Ane Claudia Fernandes Nunes",coverURL:"https://cdn.intechopen.com/books/images_new/10119.jpg",editedByType:"Edited by",editors:[{id:"55270",title:"Prof.",name:"Ane",middleName:null,surname:"Claudia Fernandes Nunes",slug:"ane-claudia-fernandes-nunes",fullName:"Ane Claudia Fernandes Nunes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7905",title:"Saliva and Salivary Diagnostics",subtitle:null,isOpenForSubmission:!1,hash:"ae7cd7860043968aa88daae89795a591",slug:"saliva-and-salivary-diagnostics",bookSignature:"Sridharan Gokul",coverURL:"https://cdn.intechopen.com/books/images_new/7905.jpg",editedByType:"Edited by",editors:[{id:"82453",title:"Dr.",name:"Gokul",middleName:null,surname:"Sridharan",slug:"gokul-sridharan",fullName:"Gokul Sridharan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7078",title:"Essentials of Abdominal Ultrasound",subtitle:null,isOpenForSubmission:!1,hash:"7e4ceded2111e9afc134431fe730ceb9",slug:"essentials-of-abdominal-ultrasound",bookSignature:"Samia Ali Abdo Gamie and Enas Mahmoud Foda",coverURL:"https://cdn.intechopen.com/books/images_new/7078.jpg",editedByType:"Edited by",editors:[{id:"204157",title:"Prof.",name:"Samia",middleName:null,surname:"Ali Abdo Gamie",slug:"samia-ali-abdo-gamie",fullName:"Samia Ali Abdo Gamie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8327",title:"Magnetic Resonance Imaging",subtitle:null,isOpenForSubmission:!1,hash:"79048b34f313bc52c7c3ddf7590c1013",slug:"magnetic-resonance-imaging",bookSignature:"Lachezar Manchev",coverURL:"https://cdn.intechopen.com/books/images_new/8327.jpg",editedByType:"Edited by",editors:[{id:"252432",title:"Associate Prof.",name:"Lachezar",middleName:null,surname:"Manchev",slug:"lachezar-manchev",fullName:"Lachezar Manchev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6954",title:"Liquid Biopsy",subtitle:null,isOpenForSubmission:!1,hash:"2599f990e6d067a23d34a27c6ca0efac",slug:"liquid-biopsy",bookSignature:"Ilze Strumfa and Janis Gardovskis",coverURL:"https://cdn.intechopen.com/books/images_new/6954.jpg",editedByType:"Edited by",editors:[{id:"54021",title:"Prof.",name:"Ilze",middleName:null,surname:"Strumfa",slug:"ilze-strumfa",fullName:"Ilze Strumfa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7541",title:"Neuroimaging",subtitle:"Structure, Function and Mind",isOpenForSubmission:!1,hash:"78ba05f58bfd6c4bf170a1f46dc39108",slug:"neuroimaging-structure-function-and-mind",bookSignature:"Sanja Josef Golubic",coverURL:"https://cdn.intechopen.com/books/images_new/7541.jpg",editedByType:"Edited by",editors:[{id:"225125",title:"Ph.D.",name:"Sanja",middleName:null,surname:"Josef Golubic",slug:"sanja-josef-golubic",fullName:"Sanja Josef Golubic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",isOpenForSubmission:!1,hash:"d92fd8cf5a90a47f2b8a310837a5600e",slug:"non-invasive-diagnostic-methods-image-processing",bookSignature:"Mariusz Marzec and Robert Koprowski",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",editedByType:"Edited by",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6047",title:"Breast Imaging",subtitle:"New Perspectives in",isOpenForSubmission:!1,hash:"2b3268435a9bd92c63ad53721f0c0262",slug:"new-perspectives-in-breast-imaging",bookSignature:"Arshad M. Malik",coverURL:"https://cdn.intechopen.com/books/images_new/6047.jpg",editedByType:"Edited by",editors:[{id:"63407",title:"Dr.",name:"Arshad",middleName:null,surname:"Malik",slug:"arshad-malik",fullName:"Arshad Malik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6005",title:"Computed Tomography",subtitle:"Advanced Applications",isOpenForSubmission:!1,hash:"8a17c8499e693346539688f5d170a43d",slug:"computed-tomography-advanced-applications",bookSignature:"Ahmet Mesrur Halefoglu",coverURL:"https://cdn.intechopen.com/books/images_new/6005.jpg",editedByType:"Edited by",editors:[{id:"51736",title:"Prof.",name:"Ahmet Mesrur",middleName:null,surname:"Halefoğlu",slug:"ahmet-mesrur-halefoglu",fullName:"Ahmet Mesrur Halefoğlu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5788",title:"Radionuclide Treatments",subtitle:null,isOpenForSubmission:!1,hash:"74470523e239330fe533a82a01b906b6",slug:"radionuclide-treatments",bookSignature:"Cigdem Soydal",coverURL:"https://cdn.intechopen.com/books/images_new/5788.jpg",editedByType:"Edited by",editors:[{id:"193283",title:"M.D.",name:"Cigdem",middleName:null,surname:"Soydal",slug:"cigdem-soydal",fullName:"Cigdem Soydal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5611",title:"Radiotherapy",subtitle:null,isOpenForSubmission:!1,hash:"717930dc57231d23f495dab6a767fd79",slug:"radiotherapy",bookSignature:"Cem Onal",coverURL:"https://cdn.intechopen.com/books/images_new/5611.jpg",editedByType:"Edited by",editors:[{id:"43940",title:"Dr.",name:"Cem",middleName:null,surname:"Onal",slug:"cem-onal",fullName:"Cem Onal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:61,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"40113",doi:"10.5772/49957",title:"Normalization of EMG Signals: To Normalize or Not to Normalize and What to Normalize to?",slug:"normalization-of-emg-signals-to-normalize-or-not-to-normalize-and-what-to-normalize-to-",totalDownloads:12204,totalCrossrefCites:83,totalDimensionsCites:177,abstract:null,book:{id:"2996",slug:"computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges",title:"Computational Intelligence in Electromyography Analysis",fullTitle:"Computational Intelligence in Electromyography Analysis - A Perspective on Current Applications and Future Challenges"},signatures:"Mark Halaki and Karen Ginn",authors:[{id:"151305",title:"Prof.",name:"Karen",middleName:null,surname:"Ginn",slug:"karen-ginn",fullName:"Karen Ginn"},{id:"153880",title:"Dr.",name:"Mark",middleName:null,surname:"Halaki",slug:"mark-halaki",fullName:"Mark Halaki"}]},{id:"40123",doi:"10.5772/50639",title:"The Usefulness of Mean and Median Frequencies in Electromyography Analysis",slug:"the-usefulness-of-mean-and-median-frequencies-in-electromyography-analysis",totalDownloads:10675,totalCrossrefCites:100,totalDimensionsCites:141,abstract:null,book:{id:"2996",slug:"computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges",title:"Computational Intelligence in Electromyography Analysis",fullTitle:"Computational Intelligence in Electromyography Analysis - A Perspective on Current Applications and Future Challenges"},signatures:"Angkoon Phinyomark, Sirinee Thongpanja, Huosheng Hu, Pornchai Phukpattaranont and Chusak Limsakul",authors:[{id:"51537",title:"Dr.",name:"Pornchai",middleName:null,surname:"Phukpattaranont",slug:"pornchai-phukpattaranont",fullName:"Pornchai Phukpattaranont"},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark"},{id:"69653",title:"Dr.",name:"Chusak",middleName:null,surname:"Limsakul",slug:"chusak-limsakul",fullName:"Chusak Limsakul"},{id:"80399",title:"Dr.",name:"Huosheng",middleName:null,surname:"Hu",slug:"huosheng-hu",fullName:"Huosheng Hu"},{id:"151337",title:"BSc.",name:"Sirinee",middleName:null,surname:"Thongpanja",slug:"sirinee-thongpanja",fullName:"Sirinee Thongpanja"}]},{id:"36055",doi:"10.5772/36379",title:"Characterization of Bone and Bone-Based Graft Materials Using FTIR Spectroscopy",slug:"characterization-of-bone-and-bone-based-graft-materials-using-ftir-spectroscopy",totalDownloads:3703,totalCrossrefCites:26,totalDimensionsCites:80,abstract:null,book:{id:"2266",slug:"infrared-spectroscopy-life-and-biomedical-sciences",title:"Infrared Spectroscopy",fullTitle:"Infrared Spectroscopy - Life and Biomedical Sciences"},signatures:"M.M. Figueiredo, J.A.F. Gamelas and A.G. Martins",authors:[{id:"108115",title:"Prof.",name:"Maria Margarida",middleName:null,surname:"Figueiredo",slug:"maria-margarida-figueiredo",fullName:"Maria Margarida Figueiredo"},{id:"118407",title:"Dr.",name:"José António",middleName:null,surname:"Gamelas",slug:"jose-antonio-gamelas",fullName:"José António Gamelas"},{id:"118408",title:"MSc.",name:"Gabriela",middleName:null,surname:"Martins",slug:"gabriela-martins",fullName:"Gabriela Martins"}]},{id:"28786",doi:"10.5772/23146",title:"Functional Near-Infrared Spectroscopy (fNIRS): Principles and Neuroscientific Applications",slug:"functional-near-infrared-spectroscopy-fnirs-brain-studies-and-others-clinical-uses",totalDownloads:4308,totalCrossrefCites:35,totalDimensionsCites:56,abstract:null,book:{id:"389",slug:"neuroimaging-methods",title:"Neuroimaging",fullTitle:"Neuroimaging - Methods"},signatures:"José León-Carrión and Umberto León-Domínguez",authors:[{id:"50810",title:"Prof.",name:"Jose",middleName:null,surname:"Leon-Carrion",slug:"jose-leon-carrion",fullName:"Jose Leon-Carrion"},{id:"98537",title:"Mr.",name:"Umberto",middleName:null,surname:"León-Domínguez",slug:"umberto-leon-dominguez",fullName:"Umberto León-Domínguez"}]},{id:"40131",doi:"10.5772/52556",title:"Signal Acquisition Using Surface EMG and Circuit Design Considerations for Robotic Prosthesis",slug:"signal-acquisition-using-surface-emg-and-circuit-design-considerations-for-robotic-prosthesis",totalDownloads:11423,totalCrossrefCites:17,totalDimensionsCites:55,abstract:null,book:{id:"2996",slug:"computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges",title:"Computational Intelligence in Electromyography Analysis",fullTitle:"Computational Intelligence in Electromyography Analysis - A Perspective on Current Applications and Future Challenges"},signatures:"Muhammad Zahak Jamal",authors:[{id:"151261",title:"B.Sc.",name:"Zahak",middleName:null,surname:"Jamal",slug:"zahak-jamal",fullName:"Zahak Jamal"}]}],mostDownloadedChaptersLast30Days:[{id:"44811",title:"Clinical Quantitative Electromyography",slug:"clinical-quantitative-electromyography",totalDownloads:3349,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"3390",slug:"electrodiagnosis-in-new-frontiers-of-clinical-research",title:"Electrodiagnosis in New Frontiers of Clinical Research",fullTitle:"Electrodiagnosis in New Frontiers of Clinical Research"},signatures:"Tameem Adel and Dan Stashuk",authors:[{id:"164291",title:"Prof.",name:"Daniel",middleName:null,surname:"Stashuk",slug:"daniel-stashuk",fullName:"Daniel Stashuk"},{id:"165816",title:"MSc.",name:"Tameem",middleName:null,surname:"Adel",slug:"tameem-adel",fullName:"Tameem Adel"}]},{id:"65515",title:"The Influence of Ultrasound Equipment Knobology in Abdominal Sonography",slug:"the-influence-of-ultrasound-equipment-knobology-in-abdominal-sonography",totalDownloads:3840,totalCrossrefCites:0,totalDimensionsCites:2,abstract:"Ultrasonography is a highly operator dependent imaging modality with a number of knobology variables that are under the control of the operator. Knobology is a terminology that describes the manipulation of ultrasound knobs and system controls in order to obtain the best image possible from diagnostic ultrasound. The inadequate use of knobology variables may impair image quality and can result in misdiagnosis. In abdominal sonography, selecting the appropriate application preset for abdominal examination is first step towards achieving an optimum image. The next step is to select an appropriate transducer frequency which must take the size of the patient into account. Transducer frequency is typically in the range of 3–5 MHz, but a lower frequency may achieve better depth penetration in larger patients. While the output power may improve image quality by increasing the intensity of transmitted sound energy, the impact is usually insignificant. The practice of using high output power should therefore be limited because of the risk of biologic effect. Other essential knobs for better image optimization include controlling the overall gain, time gain compensation, focal zone, dynamic range and tissue harmonic imaging. In the assessment of blood flow in abdominal vessels the regulation of the pulse repetition frequency, Doppler gain, imaging angle, and wall filter improves the sensitivity of color and spectral Doppler.",book:{id:"7078",slug:"essentials-of-abdominal-ultrasound",title:"Essentials of Abdominal Ultrasound",fullTitle:"Essentials of Abdominal Ultrasound"},signatures:"Yaw Amo Wiafe and Augustina Badu-Peprah",authors:[{id:"49471",title:"Dr.",name:"Yaw",middleName:"Amo",surname:"Wiafe",slug:"yaw-wiafe",fullName:"Yaw Wiafe"},{id:"277050",title:"Dr.",name:"Augustina",middleName:null,surname:"Badu-Peprah",slug:"augustina-badu-peprah",fullName:"Augustina Badu-Peprah"}]},{id:"53969",title:"Radiation-Related Heart Disease: Up-to-Date Developments",slug:"radiation-related-heart-disease-up-to-date-developments",totalDownloads:1811,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Approximately 25–30% of patients with cancer undergo thoracic radiation therapy (RT). RT might inadvertently induce heart injury and result in various forms of radiation-related heart disease (RRHD). The main endpoints of RRHD include cardiac death from RT, clinical heart disease (congestive heart disease, ischemic heart disease, and myocardial infarction), and subclinical heart disease (cardiac perfusion defects). Advanced RT techniques, such as breath control, intensity-modulated RT, and image-guided RT, as well as limited target volume definition might spare or avoid cardiac doses and/or volume, which may translate into decreased incidence of RRHD. The total delivered radiation dose to cardiac implantable electronic devices was strongly recommended not to exceed 2 Gy. The treatment strategies of RRHD were based on the various recommended consensus of related heart diseases in cardiology. However, the standardized definitions of the cardiac structures, dose-volume limits during radiation planning design, the optimal dose-volume parameters, and the dose-volume effects of various cardiac substructures warrant further investigation. The recognition, prediction, prevention, and management of RRHD require close collaboration between oncologists and cardiologists.",book:{id:"5611",slug:"radiotherapy",title:"Radiotherapy",fullTitle:"Radiotherapy"},signatures:"Wenyong Tan, Xianming Li and Yong Dai",authors:[{id:"192949",title:"Dr.",name:"Wenyong",middleName:null,surname:"Tan",slug:"wenyong-tan",fullName:"Wenyong Tan"},{id:"195918",title:"Prof.",name:"Xianming",middleName:null,surname:"Li",slug:"xianming-li",fullName:"Xianming Li"},{id:"195919",title:"Prof.",name:"Yong",middleName:null,surname:"Dai",slug:"yong-dai",fullName:"Yong Dai"}]},{id:"40113",title:"Normalization of EMG Signals: To Normalize or Not to Normalize and What to Normalize to?",slug:"normalization-of-emg-signals-to-normalize-or-not-to-normalize-and-what-to-normalize-to-",totalDownloads:12214,totalCrossrefCites:83,totalDimensionsCites:178,abstract:null,book:{id:"2996",slug:"computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges",title:"Computational Intelligence in Electromyography Analysis",fullTitle:"Computational Intelligence in Electromyography Analysis - A Perspective on Current Applications and Future Challenges"},signatures:"Mark Halaki and Karen Ginn",authors:[{id:"151305",title:"Prof.",name:"Karen",middleName:null,surname:"Ginn",slug:"karen-ginn",fullName:"Karen Ginn"},{id:"153880",title:"Dr.",name:"Mark",middleName:null,surname:"Halaki",slug:"mark-halaki",fullName:"Mark Halaki"}]},{id:"44210",title:"Endoscopy - An Advancement in Sinus and Skull Base Surgery",slug:"endoscopy-an-advancement-in-sinus-and-skull-base-surgery",totalDownloads:2547,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"3522",slug:"endoscopy",title:"Endoscopy",fullTitle:"Endoscopy"},signatures:"Rickul Varshney, Faisal Zawawi, Marc A Tewfik and Saul Frenkiel",authors:[{id:"59829",title:"Dr.",name:"Saul",middleName:null,surname:"Frenkiel",slug:"saul-frenkiel",fullName:"Saul Frenkiel"},{id:"96296",title:"Dr.",name:"Rickul",middleName:null,surname:"Varshney",slug:"rickul-varshney",fullName:"Rickul Varshney"},{id:"158457",title:"Dr.",name:"Marc A.",middleName:null,surname:"Tewfik",slug:"marc-a.-tewfik",fullName:"Marc A. Tewfik"},{id:"166128",title:"Dr.",name:"Faisal",middleName:null,surname:"Zawawi",slug:"faisal-zawawi",fullName:"Faisal Zawawi"}]}],onlineFirstChaptersFilter:{topicId:"176",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"22",title:"Business, Management and Economics",doi:"10.5772/intechopen.100359",issn:null,scope:"\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"May 11th, 2022",hasOnlineFirst:!1,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:0,paginationItems:[]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:7,paginationItems:[{id:"11476",title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",hash:"8d41fa5f3a5da07469bbc121594bfd3e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 24th 2022",isOpenForSubmission:!0,editors:[{id:"335401",title:"Prof.",name:"Margherita",surname:"Mori",slug:"margherita-mori",fullName:"Margherita Mori"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11460",title:"Pluralistic Approaches for Conservation and Sustainability in Biodiversity",coverURL:"https://cdn.intechopen.com/books/images_new/11460.jpg",hash:"ab014f8ed1669757335225786833e9a9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 22nd 2022",isOpenForSubmission:!0,editors:[{id:"101105",title:"Dr.",name:"Gopal",surname:"Shukla",slug:"gopal-shukla",fullName:"Gopal Shukla"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11475",title:"Food Security Challenges and Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11475.jpg",hash:"090302a30e461cee643ec49675c811ec",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"292145",title:"Dr.",name:"Muhammad",surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11450",title:"Environmental Impacts of COVID-19 Pandemic on the World",coverURL:"https://cdn.intechopen.com/books/images_new/11450.jpg",hash:"a58c7b02d07903004be70f744f2e1835",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 10th 2022",isOpenForSubmission:!0,editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11477",title:"Public Economics - New Perspectives and Uncertainty",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",hash:"a8e6c515dc924146fbd2712eb4e7d118",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"May 27th 2022",isOpenForSubmission:!0,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11457",title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",hash:"8df7150b01ae754024c65d1a62f190d9",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 1st 2022",isOpenForSubmission:!0,editors:[{id:"317087",title:"Dr.",name:"Pavel",surname:"Samec",slug:"pavel-samec",fullName:"Pavel Samec"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 2nd 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:26,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81412",title:"Mathematical Morphology and the Heart Signals",doi:"10.5772/intechopen.104113",signatures:"Taouli Sidi Ahmed",slug:"mathematical-morphology-and-the-heart-signals",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81360",title:"Deep Learning Algorithms for Efficient Analysis of ECG Signals to Detect Heart Disorders",doi:"10.5772/intechopen.103075",signatures:"Sumagna Dey, Rohan Pal and Saptarshi Biswas",slug:"deep-learning-algorithms-for-efficient-analysis-of-ecg-signals-to-detect-heart-disorders",totalDownloads:29,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81294",title:"Applications of Neural Organoids in Neurodevelopment and Regenerative Medicine",doi:"10.5772/intechopen.104044",signatures:"Jing Gong, Jiahui Kang, Minghui Li, Xiao Liu, Jun Yang and Haiwei Xu",slug:"applications-of-neural-organoids-in-neurodevelopment-and-regenerative-medicine",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81318",title:"Retinal Organoids over the Decade",doi:"10.5772/intechopen.104258",signatures:"Jing Yuan and Zi-Bing Jin",slug:"retinal-organoids-over-the-decade",totalDownloads:37,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81068",title:"Characteristic Profiles of Heart Rate Variability in Depression and Anxiety",doi:"10.5772/intechopen.104205",signatures:"Toshikazu Shinba",slug:"characteristic-profiles-of-heart-rate-variability-in-depression-and-anxiety",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"80691",title:"Applications of Quantum Mechanics, Laws of Classical Physics, and Differential Calculus to Evaluate Source Localization According to the Electroencephalogram",doi:"10.5772/intechopen.102831",signatures:"Kristin S. Williams",slug:"applications-of-quantum-mechanics-laws-of-classical-physics-and-differential-calculus-to-evaluate-so",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}}]},subseriesFiltersForOFChapters:[{caption:"Bioinformatics and Medical Informatics",value:7,count:13,group:"subseries"}],publishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9525",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",slug:"insights-into-drug-resistance-in-staphylococcus-aureus",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Amjad Aqib",hash:"98bb6c1ddb067da67185c272f81c0a27",volumeInSeries:10,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",editedByType:"Edited by",bookSignature:"Xinhui Wang",hash:"31d6882518ca749b12715266eed0a018",volumeInSeries:9,fullTitle:"Advances in Candida albicans",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/296531/images/system/296531.jpg",institutionString:"Qinghai Normal University",institution:{name:"University of Luxembourg",institutionURL:null,country:{name:"Luxembourg"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Ph.D.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:"Federal University of ABC",institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:null,institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:25,paginationItems:[{id:"429683",title:"Dr.",name:"Bilal",middleName:null,surname:"Khalid",slug:"bilal-khalid",fullName:"Bilal Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/429683/images/system/429683.png",biography:"Dr. Bilal Khalid received a Ph.D. in Industrial Business Administration from KMITL Business School, Bangkok, in 2021, and a master’s in International Business Management from Stamford International University, Bangkok, in 2017. Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:null,institution:{name:"Université Laval",country:{name:"Canada"}}},{id:"189147",title:"Dr.",name:"Hailan",middleName:null,surname:"Salamun",slug:"hailan-salamun",fullName:"Hailan Salamun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189147/images/19274_n.jpeg",biography:"Hailan Salamun, (Dr.) was born in Selangor, Malaysia and graduated from Tunku Ampuan Jamaah Religious High School at Shah Alam. Obtained a degree from the International Islamic University (UIA), Gombak in the field of Islamic Revealed Knowledge and Heritage. Next, I furthered my studies to the professional level to obtain a Diploma in Education at UIA. After serving for several years in school, I furthered my studies to the Master of Dakwah and Leadership at Universiti Kebangsaan Malaysia (UKM), Bangi. I graduated with a Doctor of Philosophy in Principalship Leadership from the University of Malaya (UM) in 2010. I am currently a senior lecturer in the Department of Nationalism and Civilization, Center for Basic and Continuing Education, Universiti Malaysia Terengganu. Prior to that, I had served in several educational institutions such as schools, the Institute of Teacher Education (IPG), and also the University of Malaya. I am also actively involved in paper presentation, writing and publishing. My research interests are focused on leadership, education, society and Islamic civilization. This area of research requires a detailed understanding of Islamic studies and research studies in leadership. Another research interest that I have explored recently is the politics of the Malay community and also the leadership of the mosque.",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"442081",title:"Dr.",name:"Audrey",middleName:null,surname:"Addy",slug:"audrey-addy",fullName:"Audrey Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kwame Nkrumah University of Science and Technology",country:{name:"Ghana"}}},{id:"437993",title:"Mr.",name:"Job",middleName:null,surname:"Jackson",slug:"job-jackson",fullName:"Job Jackson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"428495",title:"Prof.",name:"Asyraf",middleName:null,surname:"Ab Rahman",slug:"asyraf-ab-rahman",fullName:"Asyraf Ab Rahman",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"429650",title:"Dr.",name:"Jacqueline",middleName:null,surname:"Kareem",slug:"jacqueline-kareem",fullName:"Jacqueline Kareem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Christ University",country:{name:"India"}}},{id:"421041",title:"Dr.",name:"Sunil",middleName:null,surname:"Kumar Ramdas",slug:"sunil-kumar-ramdas",fullName:"Sunil Kumar Ramdas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"421833",title:"Mr.",name:"Eugene",middleName:null,surname:"Owusu-Acheampong",slug:"eugene-owusu-acheampong",fullName:"Eugene Owusu-Acheampong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"239876",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Mourão",slug:"luciana-mourao",fullName:"Luciana Mourão",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Salgado de Oliveira",country:{name:"Brazil"}}},{id:"421735",title:"Dr.",name:"elizabeth",middleName:null,surname:"addy",slug:"elizabeth-addy",fullName:"elizabeth addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"442083",title:"Dr.",name:"James",middleName:null,surname:"Addy",slug:"james-addy",fullName:"James Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437991",title:"Prof.",name:"Muhammad",middleName:null,surname:"Hoque",slug:"muhammad-hoque",fullName:"Muhammad Hoque",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421006",title:"Dr.",name:"Anna",middleName:null,surname:"Uster",slug:"anna-uster",fullName:"Anna Uster",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470243",title:"Dr.",name:"Md Samim",middleName:null,surname:"Al Azad",slug:"md-samim-al-azad",fullName:"Md Samim Al Azad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470244",title:"Dr.",name:"Slimane",middleName:null,surname:"Ed-dafali",slug:"slimane-ed-dafali",fullName:"Slimane Ed-dafali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421011",title:"Dr.",name:"Afatakpa",middleName:null,surname:"Fortune",slug:"afatakpa-fortune",fullName:"Afatakpa Fortune",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446057",title:"Mr.",name:"Okedare",middleName:null,surname:"David Olubukunmi",slug:"okedare-david-olubukunmi",fullName:"Okedare David Olubukunmi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421778",title:"Dr.",name:"Fatimah",middleName:"Saeed",surname:"AlAhmari",slug:"fatimah-alahmari",fullName:"Fatimah AlAhmari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421024",title:"Prof.",name:"Harold Andrew",middleName:null,surname:"Patrick",slug:"harold-andrew-patrick",fullName:"Harold Andrew Patrick",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421065",title:"Ms.",name:"Euzália",middleName:null,surname:"do Rosário Botelho Tomé",slug:"euzalia-do-rosario-botelho-tome",fullName:"Euzália do Rosário Botelho Tomé",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421053",title:"Associate Prof.",name:"Ken",middleName:null,surname:"Kalala Ndalamba",slug:"ken-kalala-ndalamba",fullName:"Ken Kalala Ndalamba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421826",title:"Dr.",name:"Inusah",middleName:null,surname:"Salifu",slug:"inusah-salifu",fullName:"Inusah Salifu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"420823",title:"Prof.",name:"Gardênia da Silva",middleName:null,surname:"Abbad",slug:"gardenia-da-silva-abbad",fullName:"Gardênia da Silva Abbad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437613",title:"MSc.",name:"Juliana",middleName:null,surname:"Legentil",slug:"juliana-legentil",fullName:"Juliana Legentil",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. Alhazzaa, Thomas Heinbockel and Antonei B. Csoka",slug:"diabetes-and-epigenetics",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81099",title:"SK Channels and Heart Disease",doi:"10.5772/intechopen.104115",signatures:"Katherine Zhong, Shawn Kant, Frank Sellke and Jun Feng",slug:"sk-channels-and-heart-disease",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80967",title:"Hot on the Trail of Skin Inflammation: Focus on TRPV1/TRPV3 Channels in Psoriasis",doi:"10.5772/intechopen.103792",signatures:"Lisa S. Martin, Emma Fraillon, Fabien P. Chevalier and Bérengère Fromy",slug:"hot-on-the-trail-of-skin-inflammation-focus-on-trpv1-trpv3-channels-in-psoriasis",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80952",title:"TRPV Family Ion Channels in the Mammary Epithelium: Role in Normal Tissue Homeostasis and along Breast Cancer Progression",doi:"10.5772/intechopen.103665",signatures:"Sari Susanna Tojkander",slug:"trpv-family-ion-channels-in-the-mammary-epithelium-role-in-normal-tissue-homeostasis-and-along-breas",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80484",title:"The Use of Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) to Study Ivermectin-Mediated Molecular Pathway Changes in Human Ovarian Cancer Cells",doi:"10.5772/intechopen.102092",signatures:"Na Li and Xianquan Zhan",slug:"the-use-of-stable-isotope-labeling-with-amino-acids-in-cell-culture-silac-to-study-ivermectin-mediat",totalDownloads:77,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80157",title:"Structural Determinants for Ligand Accommodation in Voltage Sensors",doi:"10.5772/intechopen.102094",signatures:"Abigail García-Morales, Aylin López-Palestino and Daniel Balleza",slug:"structural-determinants-for-ligand-accommodation-in-voltage-sensors",totalDownloads:84,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"79690",title:"Mitochondrial Channels and their Role in Cardioprotection",doi:"10.5772/intechopen.101127",signatures:"Keerti Mishra and Min Luo",slug:"mitochondrial-channels-and-their-role-in-cardioprotection",totalDownloads:84,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"79031",title:"Isolation and Expansion of Mesenchymal Stem/Stromal Cells, Functional Assays and Long-Term Culture Associated Alterations of Cellular Properties",doi:"10.5772/intechopen.100286",signatures:"Chenghai Li",slug:"isolation-and-expansion-of-mesenchymal-stem-stromal-cells-functional-assays-and-long-term-culture-as",totalDownloads:73,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78960",title:"Two-Dimensional and Three-Dimensional Cell Culture and Their Applications",doi:"10.5772/intechopen.100382",signatures:"Sangeeta Ballav, Ankita Jaywant Deshmukh, Shafina Siddiqui, Jyotirmoi Aich and Soumya Basu",slug:"two-dimensional-and-three-dimensional-cell-culture-and-their-applications",totalDownloads:246,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78812",title:"Nanotechnology Application and Intellectual Property Right Prospects of Mammalian Cell Culture",doi:"10.5772/intechopen.99146",signatures:"Harikrishnareddy Rachamalla, Anubhab Mukherjee and Manash K. Paul",slug:"nanotechnology-application-and-intellectual-property-right-prospects-of-mammalian-cell-culture",totalDownloads:117,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78274",title:"A Brief Concept of Cell Culture: Challenges, Prospects and Applications",doi:"10.5772/intechopen.99387",signatures:"Md. Salauddin",slug:"a-brief-concept-of-cell-culture-challenges-prospects-and-applications",totalDownloads:169,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Cell Culture - Advanced Technology and Applications in Medical and Life Sciences",coverURL:"https://cdn.intechopen.com/books/images_new/10797.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"78415",title:"Epigenetic",doi:"10.5772/intechopen.99964",signatures:"Mehmet Ünal",slug:"epigenetic",totalDownloads:135,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"77443",title:"Cyanobacterial Phytochromes in Optogenetics",doi:"10.5772/intechopen.97522",signatures:"Sivasankari Sivaprakasam, Vinoth Mani, Nagalakshmi Balasubramaniyan and David Ravindran Abraham",slug:"cyanobacterial-phytochromes-in-optogenetics",totalDownloads:183,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"75979",title:"Spatiotemporal Regulation of Cell–Cell Adhesions",doi:"10.5772/intechopen.97009",signatures:"Brent M. Bijonowski",slug:"spatiotemporal-regulation-of-cell-cell-adhesions",totalDownloads:169,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76646",title:"Functional Mechanism of Proton Pump-Type Rhodopsins Found in Various Microorganisms as a Potential Effective Tool in Optogenetics",doi:"10.5772/intechopen.97589",signatures:"Jun Tamogami and Takashi Kikukawa",slug:"functional-mechanism-of-proton-pump-type-rhodopsins-found-in-various-microorganisms-as-a-potential-e",totalDownloads:196,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"76510",title:"Evolution of Epigenome as the Blueprint for Carcinogenesis",doi:"10.5772/intechopen.97379",signatures:"Zeenat Farooq, Ambreen Shah, Mohammad Tauseef, Riyaz A. Rather and Mumtaz Anwar",slug:"evolution-of-epigenome-as-the-blueprint-for-carcinogenesis",totalDownloads:189,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Epigenetics to Optogenetics - A New Paradigm in the Study of Biology",coverURL:"https://cdn.intechopen.com/books/images_new/9672.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},publishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"9959",title:"Biomedical Signal and Image Processing",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9959.jpg",slug:"biomedical-signal-and-image-processing",publishedDate:"April 14th 2021",editedByType:"Edited by",bookSignature:"Yongxia Zhou",hash:"22b87a09bd6df065d78c175235d367c8",volumeInSeries:10,fullTitle:"Biomedical Signal and Image Processing",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou",profilePictureURL:"https://mts.intechopen.com/storage/users/259308/images/system/259308.jpeg",institutionString:"University of Southern California",institution:{name:"University of Southern California",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9973",title:"Data Acquisition",subtitle:"Recent Advances and Applications in Biomedical Engineering",coverURL:"https://cdn.intechopen.com/books/images_new/9973.jpg",slug:"data-acquisition-recent-advances-and-applications-in-biomedical-engineering",publishedDate:"March 17th 2021",editedByType:"Edited by",bookSignature:"Bartłomiej Płaczek",hash:"75ea6cdd241216c9db28aa734ab34446",volumeInSeries:9,fullTitle:"Data Acquisition - Recent Advances and Applications in Biomedical Engineering",editors:[{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",institutionString:"University of Silesia",institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9905",title:"Biometric Systems",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9905.jpg",slug:"biometric-systems",publishedDate:"February 10th 2021",editedByType:"Edited by",bookSignature:"Muhammad Sarfraz",hash:"c730560dd2e3837a03407b3a86b0ef2a",volumeInSeries:8,fullTitle:"Biometric Systems",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",institutionString:"Kuwait University",institution:{name:"Kuwait University",institutionURL:null,country:{name:"Kuwait"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8622",title:"Peptide Synthesis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8622.jpg",slug:"peptide-synthesis",publishedDate:"December 18th 2019",editedByType:"Edited by",bookSignature:"Jaya T. Varkey",hash:"de9fa48c5248dbfb581825b8c74f5623",volumeInSeries:0,fullTitle:"Peptide Synthesis",editors:[{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",institutionString:"St. Teresa’s College",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",slug:"computer-vision-in-dentistry",publishedDate:"September 18th 2019",editedByType:"Edited by",bookSignature:"Monika Elzbieta Machoy",hash:"1e9812cebd46ef9e28257f3e96547f6a",volumeInSeries:7,fullTitle:"Computer Vision in Dentistry",editors:[{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8633",title:"Novel Diagnostic Methods in Ophthalmology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8633.jpg",slug:"novel-diagnostic-methods-in-ophthalmology",publishedDate:"September 4th 2019",editedByType:"Edited by",bookSignature:"Anna Nowinska",hash:"da2c90e8db647ead30504defce3fb5d3",volumeInSeries:6,fullTitle:"Novel Diagnostic Methods in Ophthalmology",editors:[{id:"261466",title:"Dr.",name:"Anna",middleName:"Karolina",surname:"Nowińska",slug:"anna-nowinska",fullName:"Anna Nowińska",profilePictureURL:"https://mts.intechopen.com/storage/users/261466/images/system/261466.jpeg",institutionString:"Medical University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",institutionString:"University of Silesia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.jpg",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:86,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:96,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:283,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:138,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:128,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:100,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"22",title:"Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence"},{id:"23",title:"Computational Neuroscience",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness"},{id:"24",title:"Computer Vision",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR"},{id:"25",title:"Evolutionary Computation",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization"},{id:"26",title:"Machine Learning and Data Mining",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence"},{id:"27",title:"Multi-Agent Systems",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Artificial Intelligence",id:"14"},selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 7th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:96,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:null,institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda",middleName:"R.",surname:"Gharieb",fullName:"Reda Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/220557",hash:"",query:{},params:{id:"220557"},fullPath:"/profiles/220557",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()